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<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>B8LSU9</accession>
    <name>B8LSU9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 20">Serine/threonine-protein kinase Tel1</fullName>
            <ecNumber evidence="5 20">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">TSTA_064140</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17 20">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Chromosome</location>
            <location evidence="2 20">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5 20"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340332.1">
        <property type="nucleotide sequence ID" value="XM_002340291.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LSU9"/>
    <dbReference type="GeneID" id="8105087"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_064140"/>
    <dbReference type="eggNOG" id="KOG0892">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000178_8_2_1"/>
    <dbReference type="InParanoid" id="B8LSU9"/>
    <dbReference type="OMA" id="HACSVIR"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="PhylomeDB" id="B8LSU9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05171">
        <property type="entry name" value="PIKKc_ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000025">
        <property type="entry name" value="Serine/threonine-protein kinase Tel1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000019">
        <property type="entry name" value="Serine/threonine-protein kinase Tel1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038980">
        <property type="entry name" value="ATM_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044107">
        <property type="entry name" value="PIKKc_ATM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021668">
        <property type="entry name" value="TAN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11640">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01342">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 20" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7 20" id="KW-0158">Chromosome</keyword>
    <keyword evidence="21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 20" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 20 26" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="15 20" id="KW-0779">Telomere</keyword>
    <keyword evidence="9 20 26" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="24">
        <location>
            <begin position="1841"/>
            <end position="2438"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="23">
        <location>
            <begin position="2542"/>
            <end position="2855"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="25">
        <location>
            <begin position="2872"/>
            <end position="2926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="2824"/>
            <end position="2859"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="2270"/>
            <end position="2300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="2842"/>
            <end position="2859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU365027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EED22945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="2926" mass="330157" checksum="933B196F7DB39EA6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8LSW0</accession>
    <name>B8LSW0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_064250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340343.1">
        <property type="nucleotide sequence ID" value="XM_002340302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LSW0"/>
    <dbReference type="STRING" id="441959.B8LSW0"/>
    <dbReference type="GeneID" id="8101125"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_064250"/>
    <dbReference type="eggNOG" id="ENOG502S4MP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041458_0_1_1"/>
    <dbReference type="InParanoid" id="B8LSW0"/>
    <dbReference type="OMA" id="VCSIHTD"/>
    <dbReference type="OrthoDB" id="3886346at2759"/>
    <dbReference type="PhylomeDB" id="B8LSW0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="300" mass="33147" checksum="47FEB4A2C23D6BC0" modified="2009-03-03" version="1">MLSGSVATNSMDALQCFTSISDSIPSWITRVTELAEHTSRKHAEFSEEFKRLATTNIHSIRPASDVLFQPGVAPDANTSHVSGHASPSIRLRRELIIFYDSHTQTELEGMVRDIGNARNSLRKGKLSQLMGKSNGGIDMFASARSCGIQLPRDGFRRTRLSTTAGTTQKESAFEYTDKQLETAQSLCETAAHQFLRTGDCAKVLKDILSKFETVLQTTTQEAARLREEKEREAEQQQAEAKEQQQANGVTSVYPSPLKSIIAEDDKPPEPGTATIEVDDTVSDSSISIDITAFRSNRFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8LT12</accession>
    <name>B8LT12_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HIT finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_069410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340907.1">
        <property type="nucleotide sequence ID" value="XM_002340866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LT12"/>
    <dbReference type="STRING" id="441959.B8LT12"/>
    <dbReference type="GeneID" id="8102695"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_069410"/>
    <dbReference type="eggNOG" id="KOG3362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034747_0_0_1"/>
    <dbReference type="InParanoid" id="B8LT12"/>
    <dbReference type="OMA" id="CCMCGYW"/>
    <dbReference type="OrthoDB" id="74807at2759"/>
    <dbReference type="PhylomeDB" id="B8LT12"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21437">
        <property type="entry name" value="zf-HIT_ZNHIT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039723">
        <property type="entry name" value="Vps71/ZNHIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13093">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="6">
        <location>
            <begin position="259"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="159"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED23520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="295" mass="32123" checksum="D3D60474176627AD" modified="2009-03-03" version="1">MPLVEVLGTSRSHATPGWAYVPETSLQKSSSSTAATALTSRKRGIREPGGSTTDLTSRQNHAILRHLAELDRENHRDNVHIPVPVRKDAIQRDNGRGARAKTTSNVRRIVQSQKTFRNYLDDEEAALGYASTSVMGSGAAVPAAGASKVAKIAGRRSLTPAAAASNTDMLTERQKPTKKQNTERTTTTQDNNENPEVQETPIQGGLIKSPHDNDHLLKSYIPHAPSDRLMAALLAEPPLRYHVARAAPSASGKPARRFCTICGYWGKIRCKNCGVRTCGLECYKVHEDSRCGAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8LT61</accession>
    <name>B8LT61_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thiolase-like protein type 1 additional C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_069840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340956.1">
        <property type="nucleotide sequence ID" value="XM_002340915.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340957.1">
        <property type="nucleotide sequence ID" value="XM_002340916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LT61"/>
    <dbReference type="STRING" id="441959.B8LT61"/>
    <dbReference type="GeneID" id="8101044"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_069840"/>
    <dbReference type="eggNOG" id="ENOG502QTZI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026848_0_0_1"/>
    <dbReference type="InParanoid" id="B8LT61"/>
    <dbReference type="OMA" id="YGPVGGE"/>
    <dbReference type="OrthoDB" id="435240at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040771">
        <property type="entry name" value="TLP1_add_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF139">
        <property type="entry name" value="THIOLASE-LIKE PROTEIN TYPE 1 ADDITIONAL C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18313">
        <property type="entry name" value="TLP1_add_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase-like protein type 1 additional C-terminal" evidence="4">
        <location>
            <begin position="407"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED23569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="518" mass="57087" checksum="6E735A20E4B9EF98" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTC1</accession>
    <name>B8LTC1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta lactamase domain, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_059930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002339882.1">
        <property type="nucleotide sequence ID" value="XM_002339841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTC1"/>
    <dbReference type="STRING" id="441959.B8LTC1"/>
    <dbReference type="GeneID" id="8101221"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_059930"/>
    <dbReference type="eggNOG" id="KOG0814">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_6_1_1"/>
    <dbReference type="InParanoid" id="B8LTC1"/>
    <dbReference type="OMA" id="VMDIDYA"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="PhylomeDB" id="B8LTC1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070813">
        <property type="term" value="P:hydrogen sulfide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000033">
        <property type="entry name" value="MBL fold metallo-hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051682">
        <property type="entry name" value="Mito_Persulfide_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084:SF1">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED22495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="330" mass="37162" checksum="B1E0FD6BAE41E818" modified="2009-03-03" version="1">MSNMGQPTVHAIFEKNTSTWQYIVACPSTKEAVIIDPVLDFDQEKLTISTKSAQKLLETAKSNNYRIVRLLETHAHADHLTASHYLQKALIAAGQARPPICIGKRIRTVQETFAKIYNIPEDEIRNVFDHLFSDNEEFRIGELTVKVFHLPGHTPDHVGYVIGENVFTGDSIFNPDVGSARCDFPGGDARTLWNSVQQLLSLPPRYKLYTGHDYPPASGSNDQFEGREAMPFVTVKEQQERNKHVKEGTDEEEFVKWRAERDQGLREPKLLHPALQVNVRGGQLPKNRHNGGVFFKLLVKVPADRFILVPSKPVPHVPDIAPLRTPAPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTL0</accession>
    <name>B8LTL0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_065440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340475.1">
        <property type="nucleotide sequence ID" value="XM_002340434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTL0"/>
    <dbReference type="STRING" id="441959.B8LTL0"/>
    <dbReference type="GeneID" id="8101943"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_065440"/>
    <dbReference type="eggNOG" id="ENOG502SI41">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041682_1_0_1"/>
    <dbReference type="InParanoid" id="B8LTL0"/>
    <dbReference type="OMA" id="DRPGMGN"/>
    <dbReference type="OrthoDB" id="294702at2759"/>
    <dbReference type="PhylomeDB" id="B8LTL0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF10">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="59"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="371" mass="41879" checksum="847AD8183F47E5A9" modified="2009-03-03" version="1">MPSTIKTPRTIAAEYISQRHFHRRFVLPRTETHGELAVTYADVGVQPDTTTSNHVPTFLFIPGMFGSRYLGVYIHAIAEKFGVRVLCVDRPGMGGSASVPSKSRVEIWVELVPLLLNHLGIDHVSLISHSAGTIYLLNTLVSCRDILDPDHPYIACLAPWVDPAHSHKAALQLARFIPTKAFSYWNQIPRFFQTSPVISFSGTVISSIKDKLPSNSGGDSVSYHKRQRLIEQEYGMAKDVQIELEKNITRFLFKENTVGANEETLQCLRKGAPWGVCDDYEEFVKSFVERERERRSELGESSTPEKLKIRAYFAESDVMIGKTGQKYFENCFEGYEDVLSFESSTMPDEDHDSLCSCPEVLARIFQERSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8LU14</accession>
    <name>B8LU14_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_072370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341231.1">
        <property type="nucleotide sequence ID" value="XM_002341190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LU14"/>
    <dbReference type="FunCoup" id="B8LU14">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LU14"/>
    <dbReference type="GeneID" id="8109432"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_072370"/>
    <dbReference type="eggNOG" id="ENOG502QPV0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026648_0_0_1"/>
    <dbReference type="InParanoid" id="B8LU14"/>
    <dbReference type="OMA" id="KQDRTTY"/>
    <dbReference type="OrthoDB" id="2011986at2759"/>
    <dbReference type="PhylomeDB" id="B8LU14"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018810">
        <property type="entry name" value="UPF0662"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086:SF1">
        <property type="entry name" value="CU(2+) SUPPRESSING AND BLEOMYCIN SENSITIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086">
        <property type="entry name" value="UPF0662 PROTEIN YPL260W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10303">
        <property type="entry name" value="DUF2408"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED23844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="447" mass="51729" checksum="AA0E4120FEC891E8" modified="2009-03-03" version="1">MDSPAVPVPLDPREQPILERLLRTRDALLLLKQDKSSYIKSRDVLPLYEEVIGQVEGLNAVRKNQDRDRRVPHSRLDYVLDDCFQLISLLFLTVGRNNEAPATYSLSTTVLRLLHHLEEAGFYSAKDLESISQTLDSMRETLGRGKDTHSPHLLELLESRLVECQKIFDKLRKGLEHLSPELVKYHETLVSILRSTSAANTRSKFSSSEILDLQEGLKEIQNSTKDGNFVGSDGQILEGQENVKRLWERCWRWTEIVLERKGRIDERFQEQYDRLFEIRNQLERLSMTQAWSLRETDLFQYQRKLDRIDEARVNGNFLDANNQPADLHTQRTLLYLIRRSYAYIYALLIASEPVSEALLPIYNQLQTLRRCLLEVKDSGGVSNARELYPYSMKLNSIDNMRIDGKFYIGNDIPEGQGSVNALLAECYELAYELRAAVDEDKEDREES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8LU77</accession>
    <name>B8LU77_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_060420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002339936.1">
        <property type="nucleotide sequence ID" value="XM_002339895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LU77"/>
    <dbReference type="STRING" id="441959.B8LU77"/>
    <dbReference type="GeneID" id="8107314"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_060420"/>
    <dbReference type="HOGENOM" id="CLU_1038923_0_0_1"/>
    <dbReference type="InParanoid" id="B8LU77"/>
    <dbReference type="OrthoDB" id="4225668at2759"/>
    <dbReference type="PhylomeDB" id="B8LU77"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED22549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="24210" checksum="D0EF9EE7BB976809" modified="2009-03-03" version="1">MSLHGGVSISVHKATTLPLSLARDSDNNKVIHERKTIQSLIDGSKKPPYSRIDTILTNFFPEKYGEGYYGMEIGDVSCRPTFLQKLLHGLIYIPEVLNVSHGHLHCDEIYLNDEGEIKIGDVGKSMIQTGKTKDVSRGVQAVCKIADQLLSLDSNSDTTCMSWIIAKNFVTMPSTVDPRTLLKHPFLKFSQDSWYLSSLSGLLSFVRTTGLVGCSKSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUI0</accession>
    <name>B8LUI0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UBX domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_071500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341140.1">
        <property type="nucleotide sequence ID" value="XM_002341099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUI0"/>
    <dbReference type="STRING" id="441959.B8LUI0"/>
    <dbReference type="GeneID" id="8101040"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_071500"/>
    <dbReference type="eggNOG" id="KOG2689">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047594_0_0_1"/>
    <dbReference type="InParanoid" id="B8LUI0"/>
    <dbReference type="OMA" id="AQHFPRK"/>
    <dbReference type="OrthoDB" id="10254930at2759"/>
    <dbReference type="PhylomeDB" id="B8LUI0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903094">
        <property type="term" value="P:negative regulation of protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057766">
        <property type="entry name" value="Znf-C2H2_OTU1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24560">
        <property type="entry name" value="zf-C2H2_OTU1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBA" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="134"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED23753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="311" mass="34753" checksum="884BA8224D87ECE3" modified="2009-03-03" version="1">MTASDLEQLLEMGFAKERAELAVSKTGGLQAALEWLEANQDKSLDEIKSATANTNEDEGAPALNPGEEARSLVCNECGKKFRSQAQAEFHASKTEHTDFSESTEEVAPLTEEERKARLAELREKLAAKRAIQSEQDKADQKRNEEIRRKHTKESQDIKEELQRKERIKEAAQKKKEKQEEIEAKARIRAKIAADKEERRLKAEREKAERAGQAPPQPAAPSLPTTSGAVTSKPASAYTETRLRLQTNKGNILKTFPVETTLFEVVAALSKDDGIEVQNFTQNFPRKTFDREYFGESLKDLGLTPSASLVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVH6</accession>
    <name>B8LVH6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-haloalkanoic acid dehalogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_073810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341382.1">
        <property type="nucleotide sequence ID" value="XM_002341341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVH6"/>
    <dbReference type="GeneID" id="8105108"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_073810"/>
    <dbReference type="eggNOG" id="ENOG502S2N3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_2_0_1"/>
    <dbReference type="InParanoid" id="B8LVH6"/>
    <dbReference type="OMA" id="FGFAWMQ"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="PhylomeDB" id="B8LVH6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF4">
        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="254" mass="28934" checksum="F6DB6953B92244C2" modified="2009-03-03" version="1">MASPKKHIVFDVVGTCVSFDAFFDSIEQAIGPRLLAHNVTSKFFGFAWMQTAELEHTMLRMSQREKPYAEMFKALFYRVLYMAGIDNPRSFATDEERDMCHAGYSRLELRPDCKEMIEKLRDNGFTVWCLTTGDAQRVGGYFKRAGFDMPAENLVSCHDFLKHGAPDSYPLEFFKPSMSSYKHMLEKFAPTDQKWFAAAHMWDVSAAVKAGFRGAYCSIYEKESCIEVYDTKMDAMADSLSKMADKIIAVSSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVI3</accession>
    <name>B8LVI3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_073880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341389.1">
        <property type="nucleotide sequence ID" value="XM_002341348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVI3"/>
    <dbReference type="STRING" id="441959.B8LVI3"/>
    <dbReference type="GeneID" id="8107302"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_073880"/>
    <dbReference type="eggNOG" id="ENOG502QPMX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_349554_0_0_1"/>
    <dbReference type="InParanoid" id="B8LVI3"/>
    <dbReference type="OMA" id="EINQHDW"/>
    <dbReference type="OrthoDB" id="5408998at2759"/>
    <dbReference type="PhylomeDB" id="B8LVI3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="419"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="535"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED24002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="806" mass="90770" checksum="8CE65B0948A134D8" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8LW54</accession>
    <name>B8LW54_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inclusion body clearance protein IML2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Inclusion body clearance protein iml2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_074600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Inclusion body (IB) resident protein that interacts strongly with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing after protein folding stress, probably by enabling access to the IBs of an LD-stored soluble sterol derivative that acts as a chaperone in inclusion clearing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with lipid droplet proteins.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341469.1">
        <property type="nucleotide sequence ID" value="XM_002341428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LW54"/>
    <dbReference type="FunCoup" id="B8LW54">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="GeneID" id="8107335"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_074600"/>
    <dbReference type="eggNOG" id="KOG3783">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014926_1_0_1"/>
    <dbReference type="InParanoid" id="B8LW54"/>
    <dbReference type="OMA" id="AFHSDIY"/>
    <dbReference type="OrthoDB" id="2154985at2759"/>
    <dbReference type="PhylomeDB" id="B8LW54"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED24082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="702" mass="79005" checksum="567BC219290DF54D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWC3</accession>
    <name>B8LWC3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_076050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED24234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341621.1">
        <property type="nucleotide sequence ID" value="XM_002341580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWC3"/>
    <dbReference type="STRING" id="441959.B8LWC3"/>
    <dbReference type="GeneID" id="8104252"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_076050"/>
    <dbReference type="eggNOG" id="ENOG502SDN7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060774_0_0_1"/>
    <dbReference type="InParanoid" id="B8LWC3"/>
    <dbReference type="OMA" id="QTFHYLE"/>
    <dbReference type="OrthoDB" id="5422283at2759"/>
    <dbReference type="PhylomeDB" id="B8LWC3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024642">
        <property type="entry name" value="SUZ-C"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51938">
        <property type="entry name" value="SUZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUZ" evidence="2">
        <location>
            <begin position="88"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="SUZ-C" evidence="3">
        <location>
            <begin position="246"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED24234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="306" mass="33799" checksum="080DD7330F923F67" modified="2009-03-03" version="1">MSKEQKDVPDAWEADWESLADNQDQKPETPPKKVSSKVTKAQRRAAQAEFNRKLWEEAETPQTFHYIESRSAVPLKQDFKPAVTVLSRRPQIAVRNNNIDAAGEGISNLNINGSGANLSDSDEETNKPPEMTPEERQAKALRDREEKQRKYEEARERLFGNSSTPGSNTSSPGGTRPSSRNRDSGFDSSGTRGGSGGRGRNRGHGNRDRDSNNNNNSNNREKRDSPGGTGKQRQLYDPGYSTKPNSSTSYSQRRPPQLPTERSDGEQQQQAIRPSRNPRGPDGSGRGGFGFSPRGRGTLVSRDAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWV6</accession>
    <name>B8LWV6_TALSN</name>
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        <recommendedName>
            <fullName evidence="7">PIG-P domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_079440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002341935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWV6"/>
    <dbReference type="STRING" id="441959.B8LWV6"/>
    <dbReference type="GeneID" id="8107649"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_079440"/>
    <dbReference type="eggNOG" id="KOG2257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038387_1_1_1"/>
    <dbReference type="InParanoid" id="B8LWV6"/>
    <dbReference type="OMA" id="RRIHGHY"/>
    <dbReference type="OrthoDB" id="690928at2759"/>
    <dbReference type="PhylomeDB" id="B8LWV6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052263">
        <property type="entry name" value="GPI_Anchor_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013717">
        <property type="entry name" value="PIG-P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08510">
        <property type="entry name" value="PIG-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="PIG-P" evidence="7">
        <location>
            <begin position="248"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="340"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="448"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED24589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="472" mass="52177" checksum="6FE49E28722EC89A" modified="2009-03-03" version="1">MSDLNDDLSPLSSGIDSITPFPQLEDDVNETPPTNGDDEALHMKFSPLRNRTGTAHAMIHKNSLSSASQSELQSQTESSEDARNPNDEQALSPSIEIQEDTEDAEFQSQYYVENESLEHAEDISLDSTGEDFNDEDELQEPSSDEDGDDDSQERSSNGVNMHRPFMQSTSSLSGPNAFAPPFYNRPPTPLPPSPSLTSLLRPPFSTTTSRPTTPDTSDAETPNDTEAAVAKSARIATTVPRASPKVPTYEYYGFVLYLTSSCAFLMYLLWSYLPSPFLHQLGIYYYPNRWWSLAIPAWLVMFLVYIYVALACYNTGYLTLPMTSIENIVDEAANIAVINGKGRRRPGGSEKMKPGSATSQTMSTAQNRRVHGHASSGSASGNGSLLWKDVWAESTDAVMDIPVGGVCEVLYGRDREDDPSIEAASDQYEPVYDSRRRRFQREDMLHFDGSSSYRPNNIAEYPSHTADAGSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8LX27</accession>
    <name>B8LX27_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_061650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002340023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LX27"/>
    <dbReference type="GeneID" id="8102355"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_061650"/>
    <dbReference type="HOGENOM" id="CLU_1416037_0_0_1"/>
    <dbReference type="InParanoid" id="B8LX27"/>
    <dbReference type="OrthoDB" id="4526357at2759"/>
    <dbReference type="PhylomeDB" id="B8LX27"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="192" mass="20301" checksum="640B61BCDAA32928" modified="2009-03-03" version="1">MARKGPGTDGPLQTALLESTSATTTRASEGQKIFSPIAAFLDKHRSQTTGLAPHLLRALTALSDDLALVAQQHFNAYISGISMIFILPALSPSTSSSLTPNPLSPLPPPLRPPSGLEQSTYTTITQYAPVKSTPTTHSKASTGFALCTPLNAGYAASQSILKRAMLTAAQPWSLINVLPDTYTAINYIQLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXQ7</accession>
    <name>B8LXQ7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="17">R3H domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSTA_079140</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Regulates global gene expression after oxidative stress. Interacts and stabilizes mRNAs and may regulate their transition between different cytoplasmic components after oxidative stress.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with csx1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341945.1">
        <property type="nucleotide sequence ID" value="XM_002341904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXQ7"/>
    <dbReference type="STRING" id="441959.B8LXQ7"/>
    <dbReference type="GeneID" id="8105963"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_079140"/>
    <dbReference type="eggNOG" id="KOG0108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022096_2_0_1"/>
    <dbReference type="InParanoid" id="B8LXQ7"/>
    <dbReference type="OMA" id="GMQRDDS"/>
    <dbReference type="OrthoDB" id="434258at2759"/>
    <dbReference type="PhylomeDB" id="B8LXQ7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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</entry>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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    <evidence type="ECO:0000313" key="2">
        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="703" mass="77886" checksum="9BAACEB1E6CFAEDA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="NAD_binding_8"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877328" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="498"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED21091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="56696" checksum="ECE70B100F893F9B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZI6</accession>
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        </recommendedName>
    </protein>
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        <name evidence="10" type="ORF">TSTA_093140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS4/SLD5 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EED22068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479031.1">
        <property type="nucleotide sequence ID" value="XM_002478986.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="B8LZI6">
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    </dbReference>
    <dbReference type="STRING" id="441959.B8LZI6"/>
    <dbReference type="GeneID" id="8102558"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_093140"/>
    <dbReference type="eggNOG" id="KOG3176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071893_1_0_1"/>
    <dbReference type="InParanoid" id="B8LZI6"/>
    <dbReference type="OMA" id="ILETAWI"/>
    <dbReference type="OrthoDB" id="338231at2759"/>
    <dbReference type="PhylomeDB" id="B8LZI6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11711">
        <property type="entry name" value="GINS_A_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GINS_A"/>
    </dbReference>
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        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008591">
        <property type="entry name" value="GINS_Sld5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031633">
        <property type="entry name" value="SLD5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038749">
        <property type="entry name" value="Sld5_GINS_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206">
        <property type="entry name" value="SLD5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16922">
        <property type="entry name" value="SLD5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007764">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="8">
        <location>
            <begin position="68"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein SLD5 C-terminal" evidence="9">
        <location>
            <begin position="219"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED22068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="278" mass="31593" checksum="94779F9CA9FB9F0E" modified="2009-03-03" version="1">MTMDIDDILASVDRDNYTSPESVTSDHQHLTRLWVAERAVSELLPWPAQLMDRMMERVRKQVENIEDLTASSYENSNNHVDNIGNNKNNTLNLKLSILQTDLSRTQYLIRSYLRQRLSKITKFAMHYLVLISPPAPSPSSTLQSETSEVGGIRTEDTLPNPANATSNDTSPLSASEAQFLYSHQYLLASHYRLSFLASFPPQLRRLDDNAGGTSMIQGPDMREVVLVRCLVPEVPIMVPADEIYDQEREGEIMRMGEVWVGRWEGVRKAWERGDVEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0E6</accession>
    <name>B8M0E6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-amylase, putative</fullName>
            <ecNumber evidence="8">3.2.1.98</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_084740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.98" evidence="8"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478206.1">
        <property type="nucleotide sequence ID" value="XM_002478161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0E6"/>
    <dbReference type="STRING" id="441959.B8M0E6"/>
    <dbReference type="GeneID" id="8106080"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_084740"/>
    <dbReference type="eggNOG" id="KOG0471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024572_2_0_1"/>
    <dbReference type="InParanoid" id="B8M0E6"/>
    <dbReference type="OMA" id="CVVIMSN"/>
    <dbReference type="OrthoDB" id="550577at2759"/>
    <dbReference type="PhylomeDB" id="B8M0E6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033927">
        <property type="term" value="F:glucan 1,4-alpha-maltohexaosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11318">
        <property type="entry name" value="AmyAc_bac_fung_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013776">
        <property type="entry name" value="A-amylase_thermo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006968">
        <property type="entry name" value="PRK09441.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006969">
        <property type="entry name" value="PRK09441.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001021">
        <property type="entry name" value="Alph-amls_thrmst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="7">
        <location>
            <begin position="44"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED21243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="567" mass="64843" checksum="8947E290ACDC0D15" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0U6</accession>
    <name>B8M0U6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Intracellular protein transport protein (UsoA), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_087120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478442.1">
        <property type="nucleotide sequence ID" value="XM_002478397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0U6"/>
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        <location>
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            <end position="984"/>
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        <location>
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        <location>
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        <location>
            <begin position="966"/>
            <end position="986"/>
        </location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04869"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04871"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED21479.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="986" mass="110998" checksum="4605B3FDFC78DBA6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8M171</accession>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
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    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <text evidence="2">Belongs to the major facilitator superfamily.</text>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="MFS"/>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
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    </dbReference>
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        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04730)-RELATED"/>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
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        <location>
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            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="348"/>
        </location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED21013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="609" mass="67144" checksum="C843E75BA8C85C20" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1S3</accession>
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        <submittedName>
            <fullName evidence="8">C6 transcription factor (PrnA), putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">TSTA_094060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479123.1">
        <property type="nucleotide sequence ID" value="XM_002479078.1"/>
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    <dbReference type="GeneID" id="8103734"/>
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    <dbReference type="eggNOG" id="ENOG502S0WX">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009353_0_0_1"/>
    <dbReference type="InParanoid" id="B8M1S3"/>
    <dbReference type="OMA" id="ITCLPPR"/>
    <dbReference type="OrthoDB" id="3921198at2759"/>
    <dbReference type="PhylomeDB" id="B8M1S3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AtrR-like"/>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
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    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
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    <dbReference type="PANTHER" id="PTHR46910:SF15">
        <property type="entry name" value="PRNA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
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</entry>
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    <accession>B8M2B1</accession>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
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    </dbReference>
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            <end position="135"/>
        </location>
    </feature>
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        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED21575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="290" mass="33066" checksum="12E50F6565BF8C86" modified="2009-03-03" version="1">MLDSNPSVIQFGPAGQRNVPLILFHDGGGTTMSYHYLGDLNRTVYGIHDPRFIHGRPWRDGIPEMARTYANLVRSVVPRGQVILGGWSLGGYLALETAKVLESADEHSHCIEIIGIIMLDSPYPNRVPNPPNTRLQPNRPFLEKTCPPELSMLVTRSMKRVGQMIDKWSIPSWWEDNGIQPPPIFLLRCTQMVPVQNSDASMTSSDYSSDTSNESEERVIVAVDRFRAHRLLGWELYHDTEFIKAVFDVPGHHFNLFAKENRDTTTMQLKQACKMLELPYYNNRQISRTQ</sequence>
</entry>
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        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
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    <dbReference type="STRING" id="441959.B8M2B8"/>
    <dbReference type="GeneID" id="8106915"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
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    </dbReference>
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        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="180"/>
        </location>
    </feature>
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            <begin position="412"/>
            <end position="454"/>
        </location>
    </feature>
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        <location>
            <begin position="478"/>
            <end position="505"/>
        </location>
    </feature>
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        <location>
            <begin position="428"/>
            <end position="444"/>
        </location>
    </feature>
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        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED21582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="564" mass="64904" checksum="9F21E4594D1A4D24" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2E6</accession>
    <name>B8M2E6_TALSN</name>
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        </recommendedName>
    </protein>
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    </gene>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="25676766"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="441959.B8M2E6"/>
    <dbReference type="GeneID" id="8106943"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_088460"/>
    <dbReference type="eggNOG" id="KOG3769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034765_3_0_1"/>
    <dbReference type="InParanoid" id="B8M2E6"/>
    <dbReference type="OMA" id="YLYSPGN"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="PhylomeDB" id="B8M2E6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="60S ribosomal protein L3"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="dsRBD_dom"/>
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        <property type="entry name" value="RNase_III_sf"/>
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        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML44"/>
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        <property type="entry name" value="RNase III domain-like"/>
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    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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        <source>
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            <dbReference type="ARBA" id="ARBA00023274"/>
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            <dbReference type="SMART" id="SM00358"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED21610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="384" mass="42035" checksum="B71A00005816A4EF" modified="2009-03-03" version="1">MEPLGPVAVLKDRVGWSISTVSPAAQVPEGHAADHTLSEELKPVENTQIPEAFPRAGFSNPSPKVYALHSRLALPKKFPLETLARTLRDASADPHPHFNNASLAVLGHDLLAQYTTEHIICTYPRLPMTVIYAAMYAYIGPRTLATIAGEWGVELAAVPGPEVDPGLLQFKRVQPGTEIVQDPKKTTRPNTHWRKSIASSVVHGDIFGEPDLKTKNPKYVRPQLPDLESLPGVTAEKATSTFVQAVVGGIYLHAGRPAAKRFFKEHIVSRHLDMSKLFSFTQPARDLATLCHRENIEPPVAKIISETGRHSRHPVFNVGVFSGQDKLGEGSGASLIEARTRAAVAALKGWYLYSPLEVRVPSSTEEEGAKPWKPVYVDHGEVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8M369</accession>
    <name>B8M369_TALSN</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_092910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479008.1">
        <property type="nucleotide sequence ID" value="XM_002478963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M369"/>
    <dbReference type="STRING" id="441959.B8M369"/>
    <dbReference type="GeneID" id="8099469"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_092910"/>
    <dbReference type="eggNOG" id="ENOG502SC6I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014177_4_0_1"/>
    <dbReference type="InParanoid" id="B8M369"/>
    <dbReference type="OMA" id="AWKVTCA"/>
    <dbReference type="OrthoDB" id="3905365at2759"/>
    <dbReference type="PhylomeDB" id="B8M369"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="427"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="331"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="466"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="539"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED22045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="561" mass="61960" checksum="B5B12611D698435E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8M425</accession>
    <name>B8M425_TALSN</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">TSTA_039630</name>
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    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002481157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M425"/>
    <dbReference type="STRING" id="441959.B8M425"/>
    <dbReference type="GeneID" id="8109301"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_039630"/>
    <dbReference type="eggNOG" id="ENOG502QTAT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008220_0_0_1"/>
    <dbReference type="InParanoid" id="B8M425"/>
    <dbReference type="OMA" id="DTNLPHI"/>
    <dbReference type="OrthoDB" id="38531at2759"/>
    <dbReference type="PhylomeDB" id="B8M425"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057688">
        <property type="entry name" value="DUF7928"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF2">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25550">
        <property type="entry name" value="DUF7928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="730"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="765"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="799"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="864"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="889"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7928" evidence="4">
        <location>
            <begin position="52"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="3">
        <location>
            <begin position="541"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED20768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="915" mass="102922" checksum="4B93794B12224DA1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8M498</accession>
    <name>B8M498_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral membrane protein, Mpv17/PMP22 family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_024230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479527.1">
        <property type="nucleotide sequence ID" value="XM_002479482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M498"/>
    <dbReference type="FunCoup" id="B8M498">
        <property type="interactions" value="573"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M498"/>
    <dbReference type="GeneID" id="8109605"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_024230"/>
    <dbReference type="eggNOG" id="KOG1944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049109_8_1_1"/>
    <dbReference type="InParanoid" id="B8M498"/>
    <dbReference type="OMA" id="WYQSKLA"/>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="PhylomeDB" id="B8M498"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED19093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="172" mass="19066" checksum="4EEC02DE5E2A50FE" modified="2009-03-03" version="1">MLRWYAARMAQRPLLTSSITTATLFGAGDVLAQQAVDRKGFDKHDYARTGRMVLYGGAIFGPAASAWYSVLQRHVVLKSTAATVVARVAADQLLFTPVNLFCFLSSMSIMEGTDPMEKLRKAYWPTYKTNLGVWSTVQLGNFALVPLEYRVLVVNVVSLGWNCYLSFVNSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4S2</accession>
    <name>B8M4S2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450 monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_026640</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479791.1">
        <property type="nucleotide sequence ID" value="XM_002479746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4S2"/>
    <dbReference type="STRING" id="441959.B8M4S2"/>
    <dbReference type="GeneID" id="8098944"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_026640"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_11_1"/>
    <dbReference type="InParanoid" id="B8M4S2"/>
    <dbReference type="OMA" id="WMPLDTW"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="PhylomeDB" id="B8M4S2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000063">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF237">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ATNE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED19357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="535" mass="60459" checksum="A0164E32FEF6E992" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5D9</accession>
    <name>B8M5D9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_030140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480179.1">
        <property type="nucleotide sequence ID" value="XM_002480134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5D9"/>
    <dbReference type="STRING" id="441959.B8M5D9"/>
    <dbReference type="ESTHER" id="talsn-b8m5d9">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="8106581"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_030140"/>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_14_1_1"/>
    <dbReference type="InParanoid" id="B8M5D9"/>
    <dbReference type="OMA" id="IPGRWHE"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="PhylomeDB" id="B8M5D9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF6">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="27"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED19745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="548" mass="61182" checksum="7FFCE5502D7F80AB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6K3</accession>
    <name>B8M6K3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldose 1-epimerase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_027590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479899.1">
        <property type="nucleotide sequence ID" value="XM_002479854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6K3"/>
    <dbReference type="STRING" id="441959.B8M6K3"/>
    <dbReference type="GeneID" id="8109678"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_027590"/>
    <dbReference type="eggNOG" id="KOG1604">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031753_0_0_1"/>
    <dbReference type="InParanoid" id="B8M6K3"/>
    <dbReference type="OMA" id="HNWIING"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="PhylomeDB" id="B8M6K3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000014">
        <property type="entry name" value="Aldose 1-epimerase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF6">
        <property type="entry name" value="1-EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED19465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="439" mass="47393" checksum="2DE07207402AEFBE" modified="2009-03-03" version="1">MPLATGQGRFLQLGSGSSFILYFKRLAKRHLSFVAMRFQNYVSAAALFALPALGGQSSHSSSDNSTDPFKIYNITATNITASFIGYGARLVALYVPDSNGTLQDVVVGYDDPTTYVQDSETNHTFFGAVVGRYANRIKNGTFTIDGNKYQIPTNENGGADTLHGGTVGYDQRNWTVTASTKDSITFSFLDTGYEHFPGTVLNHVTYTVDALRTAVNPKGLPQLTCRIVSMSLTDKTPIMLANHIYWNLDAFQVPTILNNTLHMPLASRVVAGDNILVPNGTIFDVDTAFDGAIDYTTAKQIGADFDHAGGVCGFNCTGVDTCFIDDRVPYYVDGAVVPIIHLSSPATGITLDVATNQVAHQIYTCNGQNGTIPIKASQKARNEAAGKGGVDYVNKHGCIVIETEGWIDAINQPEWGQQEIFSPADAPTVNFATYQFGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6P2</accession>
    <name>B8M6P2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent rRNA helicase RRP3</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP-dependent rRNA helicase rrp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">TSTA_027950</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent rRNA helicase required for pre-ribosomal RNA processing. Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with the SSU processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479938.1">
        <property type="nucleotide sequence ID" value="XM_002479893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6P2"/>
    <dbReference type="FunCoup" id="B8M6P2">
        <property type="interactions" value="1121"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M6P2"/>
    <dbReference type="GeneID" id="8108311"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_027950"/>
    <dbReference type="eggNOG" id="KOG0330">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_1_1"/>
    <dbReference type="InParanoid" id="B8M6P2"/>
    <dbReference type="OMA" id="GIGIKCC"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="PhylomeDB" id="B8M6P2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17954">
        <property type="entry name" value="DEADc_DDX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044765">
        <property type="entry name" value="DDX47/Rrp3_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF20">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 17 22" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="83"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="266"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="440"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EED19504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="478" mass="52689" checksum="BD13BFB8CEE40814" modified="2009-03-03" version="1">MPGFKKRKISHERVAEGENVSDDSRSSQEDVQESAAEEAESHNDDGAAKAPKTFKDLGLIPQLCEACDTLGYKAPTAIQTEAIPLALQNRDLIGLAETGSGKTAAFALPILQALMDKPQPFFGLVLAPTRELAYQISEAFEALGSTISVRSVVLVGGMDMVPQAIAIGKRPHIIVATPGRLLDHLENTKGFSLRSLKYLVMDEADRLLDMDFGPIIDKILKVLPRERRTFLFSATMSSKVEGLQRASLSNPLRVSVSSNKYQTVSTLLQYYLFIPHKHKDVHLIWLLNEHVGQSVIIFTRTVHETMRLTILARALGFGAIALHGQLSQSARLGALGKFRSRSRDILIATDVAARGLDIPSVDLVLNYDLAADSKTHVHRIGRTARAGKSGKAISLVTQYDVEVWLRIEKALDRKLPEYKVEKEEVLILSDRVAEAQRQAITELKDLDERKNGGRGSGPKGRRFGNGKRGRDDMDQEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7I4</accession>
    <name>B8M7I4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acid phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_028260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479971.1">
        <property type="nucleotide sequence ID" value="XM_002479926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7I4"/>
    <dbReference type="FunCoup" id="B8M7I4">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M7I4"/>
    <dbReference type="GeneID" id="8108342"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_028260"/>
    <dbReference type="eggNOG" id="KOG2157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007204_0_0_1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
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            <begin position="3"/>
            <end position="221"/>
        </location>
    </feature>
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        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="535"/>
        </location>
    </feature>
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        <location>
            <begin position="508"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="757" mass="84802" checksum="36953327B903A077" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7K3</accession>
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        <submittedName>
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        <name evidence="5" type="ORF">TSTA_028440</name>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7K3"/>
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    <dbReference type="STRING" id="441959.B8M7K3"/>
    <dbReference type="GeneID" id="8108360"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_028440"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_018776_0_0_1"/>
    <dbReference type="InParanoid" id="B8M7K3"/>
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    <dbReference type="OrthoDB" id="4703at2759"/>
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    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GTF3C_component"/>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40 repeat-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED19556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="791" mass="88771" checksum="4073C19B731840FD" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7U6</accession>
    <name>B8M7U6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tetrahydrofolate synthase</fullName>
            <ecNumber evidence="3">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_030880</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="3"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480259.1">
        <property type="nucleotide sequence ID" value="XM_002480214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7U6"/>
    <dbReference type="STRING" id="441959.B8M7U6"/>
    <dbReference type="GeneID" id="8101767"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_030880"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_376504_0_0_1"/>
    <dbReference type="InParanoid" id="B8M7U6"/>
    <dbReference type="OMA" id="ATQWFLD"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="PhylomeDB" id="B8M7U6"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057571">
        <property type="entry name" value="SDR_PhqE-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23441">
        <property type="entry name" value="SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GDHRDH"/>
    </dbReference>
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        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED19825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="737" mass="81394" checksum="0D7C1E2691884C50" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8L3</accession>
    <name>B8M8L3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL13m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_037460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480960.1">
        <property type="nucleotide sequence ID" value="XM_002480915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8L3"/>
    <dbReference type="FunCoup" id="B8M8L3">
        <property type="interactions" value="704"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M8L3"/>
    <dbReference type="GeneID" id="8100591"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_037460"/>
    <dbReference type="eggNOG" id="KOG3203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082184_1_1_1"/>
    <dbReference type="InParanoid" id="B8M8L3"/>
    <dbReference type="OMA" id="HKPIYTP"/>
    <dbReference type="OrthoDB" id="274622at2759"/>
    <dbReference type="PhylomeDB" id="B8M8L3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000007">
        <property type="entry name" value="50S ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED20526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="173" mass="19320" checksum="3DEE93A56C41F132" modified="2009-03-03" version="1">MSQTAGKTRLAYSRTWHYIDVGADSRSLGRLASSIALHLMGKHKPIYDPSTDCGDYVVAVGCHDLHTTGKKRLQKKYYTHTTRPGSLKSMTMDKMFEKWGGGEVLKRAVRGMLPKNRLRDKRLARLKTFEGLQHPYKKNIVKIAGTSVLGNLPEVKQAFQEAKQTAESASASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8P4</accession>
    <name>B8M8P4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VPS9 domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_037750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480991.1">
        <property type="nucleotide sequence ID" value="XM_002480946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8P4"/>
    <dbReference type="STRING" id="441959.B8M8P4"/>
    <dbReference type="GeneID" id="8102151"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_037750"/>
    <dbReference type="eggNOG" id="KOG2319">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017705_0_0_1"/>
    <dbReference type="InParanoid" id="B8M8P4"/>
    <dbReference type="OMA" id="ETAYCLV"/>
    <dbReference type="OrthoDB" id="10264848at2759"/>
    <dbReference type="PhylomeDB" id="B8M8P4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF97">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="177"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="618"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED20557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="680" mass="73574" checksum="DCD417D208057637" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8Z7</accession>
    <name>B8M8Z7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_111360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481284.1">
        <property type="nucleotide sequence ID" value="XM_002481239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8Z7"/>
    <dbReference type="GeneID" id="8109816"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_111360"/>
    <dbReference type="HOGENOM" id="CLU_000680_26_0_1"/>
    <dbReference type="InParanoid" id="B8M8Z7"/>
    <dbReference type="OMA" id="CLGTHRI"/>
    <dbReference type="OrthoDB" id="5080849at2759"/>
    <dbReference type="PhylomeDB" id="B8M8Z7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED17292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="38202" checksum="B843BFC62A60E02B" modified="2009-03-03" version="1">MSVSDHQYLSFTETLLATIRLQRLDPYHPLRRRAEQVASNGQQTSRFARRILALPNSEQINPLQYAPWHPRESRENAQARIGAPMGRTKGQAAADFMVFQRTIPSSNIIIFSDGSRLVDGHAGGGYIGFQVHHQFLHSSLSYGYGKEVFNAEAEAALAGAQAAIAYPTAQFATNLWICLDNLEVATRLLSPSTGSSQEVFESFRTLAAAWPLRERVYLFSEAYEDLDGEREAETAPSIAVRSAALFSGILVCLGTHRIWIDPFLVCGSKTQALSTTQTQWQIIAPQTYQDLEITISPKRPEELPLNRLDLGRIIAARTGHGDFVNYHKCFNHDDAYLLCWCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8M960</accession>
    <name>B8M960_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-isopropylmalate dehydrogenase, putative</fullName>
            <ecNumber evidence="3">4.1.1.73</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_111910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.73" evidence="3"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481347.1">
        <property type="nucleotide sequence ID" value="XM_002481302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M960"/>
    <dbReference type="STRING" id="441959.B8M960"/>
    <dbReference type="GeneID" id="8098846"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_111910"/>
    <dbReference type="eggNOG" id="KOG0785">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_1_1"/>
    <dbReference type="InParanoid" id="B8M960"/>
    <dbReference type="OMA" id="AIRGPMQ"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="PhylomeDB" id="B8M960"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050319">
        <property type="term" value="F:tartrate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050501">
        <property type="entry name" value="ICDH/IPMDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43275">
        <property type="entry name" value="D-MALATE DEHYDROGENASE [DECARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43275:SF2">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="2">
        <location>
            <begin position="10"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED17355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="281" mass="30552" checksum="F0C63D728A62AF66" modified="2009-03-03" version="1">MATNAFKTYRIATIPGDGIGPLDFTELDWSTARYKKTGKYMPDDGLNVLKTFDAGIFGAVGAPEAPDLISLWNLLLAIRGPMQLYANVRPVKNSPKLPSLLRGVEDGDIDWLLVRENSEGECRGQGGRTHRGTPWEAATERIMRFAFDTARSHPRKLLTVVTKSNAMLNGMVLWDEVAAEVAREYPDVKWDKMLVDAMTVRMAANPESLDTIVGTNLHIDILSDLAAALAGSIGIAASSNLDPTRKNPSLFEPVHGSAFDITGKGIANPVATLWSASKMLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9G0</accession>
    <name>B8M9G0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_115190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481712.1">
        <property type="nucleotide sequence ID" value="XM_002481667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9G0"/>
    <dbReference type="STRING" id="441959.B8M9G0"/>
    <dbReference type="GeneID" id="8101329"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_115190"/>
    <dbReference type="HOGENOM" id="CLU_1349698_0_0_1"/>
    <dbReference type="InParanoid" id="B8M9G0"/>
    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED17720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="203" mass="23211" checksum="C4AB15287447931E" modified="2009-03-03" version="1">MLSPNALKILDHLGVYASIKGKSYNFDTLHYRDLSGKLLGTQEFGGEGKYRYRGIRIYRYVLIDRLLAACKQNLHSCQPRSSESYFDPPWIFNPINQILENKSTLSHAELDLHANLANENNQISMPNGVRVNIHRLDYFQLPQRDQNNIDLAYITPGFYAKFLAVNEPLKKLSLPSSVNSTYICRAAKMGEHQHTIIPKMVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9X8</accession>
    <name>B8M9X8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_118940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482122.1">
        <property type="nucleotide sequence ID" value="XM_002482077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9X8"/>
    <dbReference type="STRING" id="441959.B8M9X8"/>
    <dbReference type="GeneID" id="8108568"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_118940"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019225_1_0_1"/>
    <dbReference type="InParanoid" id="B8M9X8"/>
    <dbReference type="OMA" id="PLFEYSF"/>
    <dbReference type="OrthoDB" id="2915840at2759"/>
    <dbReference type="PhylomeDB" id="B8M9X8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED18130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="564" mass="63690" checksum="D0DF23F96708F461" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8MA51</accession>
    <name>B8MA51_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FGGY-family carbohydrate kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_121240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482372.1">
        <property type="nucleotide sequence ID" value="XM_002482327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MA51"/>
    <dbReference type="FunCoup" id="B8MA51">
        <property type="interactions" value="293"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MA51"/>
    <dbReference type="GeneID" id="8099364"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_121240"/>
    <dbReference type="eggNOG" id="KOG2517">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_10_1_1"/>
    <dbReference type="InParanoid" id="B8MA51"/>
    <dbReference type="OMA" id="HKAMWHE"/>
    <dbReference type="OrthoDB" id="203824at2759"/>
    <dbReference type="PhylomeDB" id="B8MA51"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019150">
        <property type="term" value="F:D-ribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019321">
        <property type="term" value="P:pentose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07782">
        <property type="entry name" value="ASKHA_NBD_FGGY_D-RBK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006003">
        <property type="entry name" value="FGGY_RbtK-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01315">
        <property type="entry name" value="5C_CHO_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435:SF4">
        <property type="entry name" value="FGGY CARBOHYDRATE KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435">
        <property type="entry name" value="RIBULOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="5">
        <location>
            <begin position="32"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="6">
        <location>
            <begin position="331"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED18380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="612" mass="67248" checksum="3290A026D90079E0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8MA85</accession>
    <name>B8MA85_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_123160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482579.1">
        <property type="nucleotide sequence ID" value="XM_002482534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MA85"/>
    <dbReference type="STRING" id="441959.B8MA85"/>
    <dbReference type="GeneID" id="8108231"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_123160"/>
    <dbReference type="eggNOG" id="ENOG502SSJH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042941_2_3_1"/>
    <dbReference type="InParanoid" id="B8MA85"/>
    <dbReference type="OMA" id="DSISIWA"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="PhylomeDB" id="B8MA85"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED18587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="33788" checksum="30A9302DD801D333" modified="2009-03-03" version="1">MTNPLGKGEEAKMEAGSGYALIQDNSGDVEEPFLQDGNISRRSNYGTFIRSPAWAVTTLILTLIMVAENVYLLRTLESSKRNSTYETGFDTELEEMKPSIKLHQKRYTGAIRDLPNGTLYMAFNSSEPRYVGPPSPEIDDAWQNLLKGRYIHFTNDETAWLNTDRDTPTGTLEQLPSHGHSISTTGYYGGPDMLHSLHCINAIRQHIGMDYYHDEHVAWLPEEYRRMHIDHCIEQLRQATLCHGDMTPVTLKAIWTNTPRWVALGQTERLHTCRDGMALREATWERGEEVGRISFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBG4</accession>
    <name>B8MBG4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD dependent epimerase/dehydratase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_116180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481820.1">
        <property type="nucleotide sequence ID" value="XM_002481775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBG4"/>
    <dbReference type="STRING" id="441959.B8MBG4"/>
    <dbReference type="GeneID" id="8099645"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_116180"/>
    <dbReference type="eggNOG" id="KOG1430">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_447717_0_0_1"/>
    <dbReference type="InParanoid" id="B8MBG4"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="PhylomeDB" id="B8MBG4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED17828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="610" mass="67411" checksum="C3C34C96AA7371E7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBK6</accession>
    <name>B8MBK6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate dehydrogenase assembly factor 2, mitochondrial</fullName>
            <shortName evidence="4">SDH assembly factor 2</shortName>
            <shortName evidence="4">SDHAF2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_116590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with the flavoprotein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SDHAF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481862.1">
        <property type="nucleotide sequence ID" value="XM_002481817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBK6"/>
    <dbReference type="STRING" id="441959.B8MBK6"/>
    <dbReference type="GeneID" id="8102051"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_116590"/>
    <dbReference type="eggNOG" id="KOG3326">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_943336_0_0_1"/>
    <dbReference type="InParanoid" id="B8MBK6"/>
    <dbReference type="OMA" id="EMEGAKF"/>
    <dbReference type="OrthoDB" id="284292at2759"/>
    <dbReference type="PhylomeDB" id="B8MBK6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.250:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase assembly factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.250">
        <property type="entry name" value="Flavinator of succinate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03057">
        <property type="entry name" value="SDHAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005631">
        <property type="entry name" value="SDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036714">
        <property type="entry name" value="SDH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028882">
        <property type="entry name" value="SDHAF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469">
        <property type="entry name" value="PROTEIN EMI5 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03937">
        <property type="entry name" value="Sdh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109910">
        <property type="entry name" value="YgfY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED17870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="303" mass="33465" checksum="6A4F1ACEA97659A5" modified="2009-03-03" version="1">MAAAQFIRSLRPTARNGLRTFPNLQPQSRAFGLSAHRANERAPSTAKGHREIQKERPLNQSIPNTTSTLTKDYPKVGADSSPPDFLSTVDPNYKPADPYPGKVEHLTGGRESAGAQKPELEVGEMEGITFKVEPLKRQGEDTSTMRARLLYQSRKRGILETDLLLSTFADVYLGNMSKEQLQQYDKFLDENDWDIYYWATQEPKQAEKIASSSAGDAGSAVKVDTPTEAWKQGAGKTGEWAQTVGAFKPAYRPVPSRWADSEILALVRQHVQDKSAVGFHAAKQKKRGGSGLGRMPDVKVFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MC32</accession>
    <name>B8MC32_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylglucosamine-6-phosphate deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_122140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate</text>
            <dbReference type="Rhea" id="RHEA:22936"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="3.5.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="2"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482470.1">
        <property type="nucleotide sequence ID" value="XM_002482425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MC32"/>
    <dbReference type="STRING" id="441959.B8MC32"/>
    <dbReference type="GeneID" id="8105500"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_122140"/>
    <dbReference type="eggNOG" id="KOG3892">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032482_0_0_1"/>
    <dbReference type="InParanoid" id="B8MC32"/>
    <dbReference type="OMA" id="PCRKGAH"/>
    <dbReference type="OrthoDB" id="10264777at2759"/>
    <dbReference type="PhylomeDB" id="B8MC32"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="8">
        <location>
            <begin position="99"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED18478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="506" mass="54743" checksum="7D44D6F3A06840E5" modified="2009-03-03" version="1">MSHRAEEPFVSCYVPSECAWPGPQAYTQEADSSDIMPTRQPTSPPCITKFTNCRILKANQLIEQDLWIDSLTGKVLKDQEAFYELHLSPDQVIDLNGRILAPGFIDVQLNGAQGFDYSVPQATKEEYDAGFIASNRGLIKTGVTSFLPTTVSTTAENYKKVLPSLAPTGRRRPEDGAESLGAHVEGPFISPSRNGIHKPEVLLASTEGFQDIINCYGRENIPEVITHDENGTIDEGVATPTPATPIAKSLHKSIHANGLTNGHTQHGSARPAIKMITAAPEVGTMIKNIPDLTSRGIIYSIGHSDATYEQAMSAVGQGAKMITHLFNAMRPFYHRNPGVFGLLGQSDLPKPYFGVIADGIHLHPTSIKIAYNAHSEGLILVTDAMRLCGLPDGVYDWTNGDRIIKKGVRLTLEGSDKIAGSSATLIECVNNFRRWTSATTAEALSAVTLTPAKMLGMEKVKGTLDHGADADLVVLGETIDSYSGPTLTVDQVWKFGIKVFDSEESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCU5</accession>
    <name>B8MCU5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_127050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482989.1">
        <property type="nucleotide sequence ID" value="XM_002482944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCU5"/>
    <dbReference type="GeneID" id="8099132"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_127050"/>
    <dbReference type="HOGENOM" id="CLU_2759531_0_0_1"/>
    <dbReference type="InParanoid" id="B8MCU5"/>
    <dbReference type="OMA" id="WRTNAPR"/>
    <dbReference type="OrthoDB" id="4507940at2759"/>
    <dbReference type="PhylomeDB" id="B8MCU5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="12"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="70" mass="8071" checksum="68D39928AE01F71F" modified="2009-03-03" version="1">MTQTLAKATTNELQEYLDSGTVKKKPCDFWKEIEDEYPTLARVARDIFLIPTTGAGVERLFNSARDIYHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MD69</accession>
    <name>B8MD69_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_114080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481586.1">
        <property type="nucleotide sequence ID" value="XM_002481541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MD69"/>
    <dbReference type="STRING" id="441959.B8MD69"/>
    <dbReference type="GeneID" id="8109170"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_114080"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017278_0_0_1"/>
    <dbReference type="InParanoid" id="B8MD69"/>
    <dbReference type="OMA" id="MIFRQKP"/>
    <dbReference type="OrthoDB" id="431169at2759"/>
    <dbReference type="PhylomeDB" id="B8MD69"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12245">
        <property type="entry name" value="RRM_scw1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000089">
        <property type="entry name" value="RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="340"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="418"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED17594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="546" mass="57580" checksum="AE23AA8C6663B745" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8ME34</accession>
    <name>B8ME34_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_012200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483345.1">
        <property type="nucleotide sequence ID" value="XM_002483300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ME34"/>
    <dbReference type="STRING" id="441959.B8ME34"/>
    <dbReference type="GeneID" id="8104068"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_012200"/>
    <dbReference type="eggNOG" id="ENOG502RXU0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033727_0_0_1"/>
    <dbReference type="InParanoid" id="B8ME34"/>
    <dbReference type="OMA" id="IPLFVNH"/>
    <dbReference type="OrthoDB" id="18110at2759"/>
    <dbReference type="PhylomeDB" id="B8ME34"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23524:SF1">
        <property type="entry name" value="MRH DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23524">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED16111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="573" mass="61296" checksum="4A385071B9022819" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEK9</accession>
    <name>B8MEK9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alcohol acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_017110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483870.1">
        <property type="nucleotide sequence ID" value="XM_002483825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEK9"/>
    <dbReference type="STRING" id="441959.B8MEK9"/>
    <dbReference type="GeneID" id="8103684"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_017110"/>
    <dbReference type="eggNOG" id="ENOG502RC91">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024469_1_0_1"/>
    <dbReference type="InParanoid" id="B8MEK9"/>
    <dbReference type="OMA" id="RIFFEPE"/>
    <dbReference type="OrthoDB" id="2150604at2759"/>
    <dbReference type="PhylomeDB" id="B8MEK9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010828">
        <property type="entry name" value="Atf2/Sli1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07247">
        <property type="entry name" value="AATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED16636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="49435" checksum="3FA1F5D9FF92C16D" modified="2009-03-03" version="1">MVRQRVASPYEKRLAIREDLGYFNSAAVGGVYEFDNGEFEVKLAHSYMPALKSCIETYPQMMMVMKGKDTNEPLWEVVPHLNLADHVSILTEQAIEDEGEAAVIEKVLPSIVDQKFTDPSSPPWRLVVLPFLSTSNPRCFIAYVSSHATADGGSGCVFHRTFMSALRKFAAVQLDDTVIKASEASLPEPFDTPERLPISPEFMKSLASANVVDGNTWTGSPVFLGPEGLQTGLRIIEIGNSQVKSALAASRVHGTKLTGLFHQLVVRALSKAIPVENGTNFASQTAIDMRAANGSTLAWGNFVSGLSHSHQRTDSSKPISDETWANARVISDKLAECSLRLEDQMIGMIRFVPDHRASMTQKLGKSRDASFALSNLNAFDGVTEGGVCKISKFLMATSAAVPSATLSFCIASVKDGNLTCVVTWQKGALGCLPEQEHTLLDVICSSIKEDFESLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEN0</accession>
    <name>B8MEN0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_019740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484147.1">
        <property type="nucleotide sequence ID" value="XM_002484102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEN0"/>
    <dbReference type="STRING" id="441959.B8MEN0"/>
    <dbReference type="GeneID" id="8104669"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_019740"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_3_1_1"/>
    <dbReference type="InParanoid" id="B8MEN0"/>
    <dbReference type="OMA" id="HEHRTAK"/>
    <dbReference type="OrthoDB" id="4159828at2759"/>
    <dbReference type="PhylomeDB" id="B8MEN0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="169"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="475" mass="52673" checksum="31AB359FA6E34616" modified="2009-03-03" version="1">MTEEDLDALAEKLTSAIQGAYRGSAKRTLTQGIGQPWWNEDCKKALHNYRSGLCSKADFRRITRWSQRQFWREKLSTVTQMKDVFDMSKWHKSTGTLRSPPLKDPLRPNSFPAVATHEKRDVLVRNLLQNSAEAGDIPLDSPAVPTTSLYFPDISMIQVEESVLQAGNTAPGADEIPTCILKVAWPLIKDKTDWSSPRSYRPIALLSVLGKGLERLVARNMAWTSIHHKVLARQQFRALPLRSATDLTTCLTHDVEQALNQGMTASLLTLDVKGAFDAVLPGRLIRRLREQGWPTNLVLWIASFATGRSVQIRLDGEIGPSTDIACGLPQGSPVSGILFMLYIAPLFRLGNPRNRFGYADDVANLAISTSLATNCVALSDSLQEALNWGAAEGITFAPDKYELLHFSRHKADQDPTRTPSVKAGSITISENTKWLYLQWLGILFDKKLTFKWHIGEAASKALTIANALRSLGNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MF29</accession>
    <name>B8MF29_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_012370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483362.1">
        <property type="nucleotide sequence ID" value="XM_002483317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MF29"/>
    <dbReference type="STRING" id="441959.B8MF29"/>
    <dbReference type="GeneID" id="8104085"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_012370"/>
    <dbReference type="HOGENOM" id="CLU_2307944_0_0_1"/>
    <dbReference type="InParanoid" id="B8MF29"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="PhylomeDB" id="B8MF29"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016129">
        <property type="entry name" value="Caspase_his_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF3">
        <property type="entry name" value="PROTEIN HU-LI TAI SHAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01121">
        <property type="entry name" value="CASPASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="2">
        <location>
            <begin position="23"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED16128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="100" mass="10538" checksum="AC15A8022562996C" modified="2009-03-03" version="1">MAPTAVASATQAAKHGHELSHSTPLEVLSHGERIAASLGPLGKGCILRNHGILAVGKTVNEAAFLFTSMESSCQVQLLVEATGRPKVLITEEEAKFNFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8MF33</accession>
    <name>B8MF33_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_012410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483366.1">
        <property type="nucleotide sequence ID" value="XM_002483321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MF33"/>
    <dbReference type="GeneID" id="8104089"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_012410"/>
    <dbReference type="HOGENOM" id="CLU_660785_0_0_1"/>
    <dbReference type="InParanoid" id="B8MF33"/>
    <dbReference type="OrthoDB" id="3430910at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="333" mass="37665" checksum="A49BD46990101269" modified="2009-03-03" version="1" fragment="single">MNIQEQIDRRPKNRGPTCRYLATNRNSIFKDIPFEQFIPLAFHTTVPQLQAANLDQLVNLVCQKYKSDLYIDWQRYCKDLGSEEQRVIATLEGAFHFAAESISSLEYRKLWKSSCCLLLRDLENLKTTAGETTGEISDRKRKRGDDENCSNASNRCYDAKKPKTSRDMSIVDVSARAMHAPETDNLHRQPISTIPLSYYQETFYKIVLAKITKVPAFKDILGRRLYEDVIKSRSISLGDPVVQLHMPATPDEDCVLQVSISISTGKIILDGKNGSFELIDAIGHYLFRAMMKTKLSGRDTGLRGTIGLDGHDLFLAIDFTTGKHMMSLEAQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFI7</accession>
    <name>B8MFI7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_017950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483955.1">
        <property type="nucleotide sequence ID" value="XM_002483910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFI7"/>
    <dbReference type="STRING" id="441959.B8MFI7"/>
    <dbReference type="GeneID" id="8109051"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_017950"/>
    <dbReference type="eggNOG" id="KOG1530">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089574_0_0_1"/>
    <dbReference type="InParanoid" id="B8MFI7"/>
    <dbReference type="OMA" id="MVFYCKA"/>
    <dbReference type="OrthoDB" id="566238at2759"/>
    <dbReference type="PhylomeDB" id="B8MFI7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF10">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="106"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="227" mass="25157" checksum="F1AAD92295CA3C7F" modified="2009-03-03" version="1">MSANVAVGVARRGARSVFGASAFSRSSSFVFRSRNIQIASQRVKNFSTERYQLLKIQYCSPQHYQSRFNLQQQQQHRKYSSENAPVFKQIGFDDINTKLSLSPSSTPSNIILIDVREPAELAATGIIPGAVSVPLASQPDAYFLPPEEFETRFGYTKPGFEQSSSPETAGKEKKEIIFYCKAGVRAQAAAQLAVQAGYDPDTLGVYRGSWLDWTNKGGKVEKWEGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFT5</accession>
    <name>B8MFT5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Polyketide synthase, putative</fullName>
            <ecNumber evidence="12">2.3.1.161</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_009240</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.161" evidence="12"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483036.1">
        <property type="nucleotide sequence ID" value="XM_002482991.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MFT5"/>
    <dbReference type="GeneID" id="8100785"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_009240"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_31_0_1"/>
    <dbReference type="InParanoid" id="B8MFT5"/>
    <dbReference type="OMA" id="GYGMISE"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="PhylomeDB" id="B8MFT5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050637">
        <property type="term" value="F:lovastatin nonaketide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF50">
        <property type="entry name" value="HIGHLY REDUCING POLYKETIDE SYNTHASE SRDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="19"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="973"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="9">
        <location>
            <begin position="973"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="9">
        <location>
            <begin position="1127"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="9">
        <location>
            <position position="1005"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="9">
        <location>
            <position position="1197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED15802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="2436" mass="268706" checksum="D99A7CB951BAF002" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGC2</accession>
    <name>B8MGC2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transposon, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_013450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483476.1">
        <property type="nucleotide sequence ID" value="XM_002483431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGC2"/>
    <dbReference type="GeneID" id="8099144"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_013450"/>
    <dbReference type="eggNOG" id="ENOG502S2ZX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_4_2_1"/>
    <dbReference type="InParanoid" id="B8MGC2"/>
    <dbReference type="OMA" id="CKANEAF"/>
    <dbReference type="OrthoDB" id="4207519at2759"/>
    <dbReference type="PhylomeDB" id="B8MGC2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="60"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED16242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="369" mass="42792" checksum="7CED99AD0C7590A4" modified="2009-03-03" version="1">MPPIRNKNEKNLAEQEGRILLAISDLKNGKISSVYQAAIIYNIPRTTLYDRLNGIQQRSIIRANGHKLSQFEEESLVKWVLDLDKRGFPPRHSLVREMANYLLSQRGNQQVGEKWVYNLIQRRPEIESKFSRKYNYERAKCEDPKLIQEYFDRVREVISKYGILPEDIYNFDETGFAMGLCATAKPGNREWVTAIEAINSTGWALPSYIIFKAKKYTRLGWFEDLPDDWRINISDNGWTIDKIELEWLKTHFIPLTNARAMGNYRMLILDGHGSHLTAEFDRTCTENNIIPVCMPPHSSHLLQPLDVGCFAVLKRHYGQLVEQRMRLGFNHIDKLDFLTAFPKARTMAYKAQTVRNSFIATGFVPFSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHR6</accession>
    <name>B8MHR6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Estradiol 17 beta-dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_014880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483630.1">
        <property type="nucleotide sequence ID" value="XM_002483585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHR6"/>
    <dbReference type="STRING" id="441959.B8MHR6"/>
    <dbReference type="GeneID" id="8107871"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_014880"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_13_1_1"/>
    <dbReference type="InParanoid" id="B8MHR6"/>
    <dbReference type="OMA" id="IAGFKEC"/>
    <dbReference type="OrthoDB" id="5371740at2759"/>
    <dbReference type="PhylomeDB" id="B8MHR6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877599" evidence="5">
        <location>
            <begin position="29"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED16396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="321" mass="35156" checksum="59996477DAFFC24A" modified="2009-03-03" version="1">MSRISPNQFLLSSSLIGLVAVLTGGAQGVGQSLVEQLHSAGAKIIFGDVDDKLSTNLVSALNQNDTEETKRVHFVHCDTSNYTDQLRLFQTAYKLYSRIDIVIANAGIAIHRDPFAPTLDSEESILIAPNTAEIDVNLKGPLYTTRLGLHYLRKNDPSRTNGYKGDIVLVSSIAGFKECEGLTTYTASKHGVIGLMRGLALQGEKEGIRINTICPWMTKTRLVTGIEQGWYNLGLPANEPEDVARAILICATANRSKSQRHEGAVLPFSGKIVWVGGGKSYEIEDRIRALEPEWLGRENSEVLKKGQEYLHSGKTSWDASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>B8MI67</accession>
    <name>B8MI67_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_022830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484463.1">
        <property type="nucleotide sequence ID" value="XM_002484418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MI67"/>
    <dbReference type="GeneID" id="8107120"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_022830"/>
    <dbReference type="HOGENOM" id="CLU_2639776_0_0_1"/>
    <dbReference type="InParanoid" id="B8MI67"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002875142" evidence="1">
        <location>
            <begin position="19"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="77" mass="8972" checksum="E68B32F7903B0CDA" modified="2009-03-03" version="1">MKASIVLSALFLGQLALALPAPNLNVDIAEKRGEEVEDWIYPDRKAKRGEEVEDWIYPDRKTKRGEEVEDWIYPDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8MID0</accession>
    <name>B8MID0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular thaumatin domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_040930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484567.1">
        <property type="nucleotide sequence ID" value="XM_002484522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MID0"/>
    <dbReference type="STRING" id="441959.B8MID0"/>
    <dbReference type="GeneID" id="8099901"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_040930"/>
    <dbReference type="eggNOG" id="ENOG502SSWE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_696723_0_0_1"/>
    <dbReference type="InParanoid" id="B8MID0"/>
    <dbReference type="OrthoDB" id="5144514at2759"/>
    <dbReference type="PhylomeDB" id="B8MID0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877755" evidence="1">
        <location>
            <begin position="20"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="2">
        <location>
            <begin position="216"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED14614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="396" mass="43688" checksum="56D8487533C8CBD9" modified="2009-03-03" version="1">MMFTKTIAAIASLGALASALPATFDRRGNSAAGGVDIINNMDKTIYLWSVSNTADAEMITLPPGGQGYSEDWRLNPDGGGISIKLSTTPDQSDVLQYEYTLVEPTIYWDLSCINMGSGSTFTTAGFAVTSNDSGNCPSATCKPGDSACADAYLIPTDDHATHGCPDAVHGSMRYQSCALECEGWPKKTAKQKAIERNANLRDEYYHYISDSCSYHLVYVDESGCDKRIGFRKTGWSPLGVAPCQVAKFHRDQRFQILPAYAQDGVVLSRVFQGSTDAPVFEDFIEELLHHCGKWPEPKSVLVMDNASFHHSEKIEQICIKAGVKLVYLPPYSPDLNPFEELFAGRKAFIKRHWQAYEDNPKQGFDSFLEWCVETVGARKRSAEGHFGNAGWTIEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIJ0</accession>
    <name>B8MIJ0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_045440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485035.1">
        <property type="nucleotide sequence ID" value="XM_002484990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIJ0"/>
    <dbReference type="STRING" id="441959.B8MIJ0"/>
    <dbReference type="GeneID" id="8099508"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_045440"/>
    <dbReference type="eggNOG" id="ENOG502SCIP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010004_1_0_1"/>
    <dbReference type="InParanoid" id="B8MIJ0"/>
    <dbReference type="OrthoDB" id="4509841at2759"/>
    <dbReference type="PhylomeDB" id="B8MIJ0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="578"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="644"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="191"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="691"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED15082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="705" mass="79583" checksum="0DF197C3399AD940" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJ79</accession>
    <name>B8MJ79_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_041460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484621.1">
        <property type="nucleotide sequence ID" value="XM_002484576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJ79"/>
    <dbReference type="GeneID" id="8109731"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_041460"/>
    <dbReference type="HOGENOM" id="CLU_880472_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJ79"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="PhylomeDB" id="B8MJ79"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="316" mass="34493" checksum="FE7B84912F27CA5F" modified="2009-03-03" version="1">MDAIFGTNSGGMDLFAVLAKLEGTGIPLGYCLVELLKAPQANSVQTKPRRTDPGAMTHVIQQFLERLENNISSRCRLDAESRRQVFSLCLLQLPGSTLLYGNDAGGRLEYLEKRVRQLEQEKRDLVSRNSSGHPFATLSDNHRISSQAQTFSSPPSTTRASSINTQYQQQDIKSIDDGKLRNTNTASTYNESLSHDSDRITKDQPLAHEVGLFSLANVVSVPKYLGPSSGVAFVRLIYASAPQTQGLPSRVCLQGDTGNRTAQRDIAQPVGLPSSAACQQFADSYFSTLGQLYPFILEDEFDELLGAGQKSSGNQN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-10-13" modified="2025-06-18" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJJ5</accession>
    <name>EFGM_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor G, mitochondrial</fullName>
            <shortName evidence="1">EF-Gmt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Elongation factor G 1, mitochondrial</fullName>
            <shortName evidence="1">mEF-G 1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Elongation factor G1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">mef1</name>
        <name type="ORF">TSTA_046490</name>
    </gene>
    <organism>
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485148.1">
        <property type="nucleotide sequence ID" value="XM_002485103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJJ5"/>
    <dbReference type="SMR" id="B8MJJ5"/>
    <dbReference type="FunCoup" id="B8MJJ5">
        <property type="interactions" value="658"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MJJ5"/>
    <dbReference type="GeneID" id="8099560"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_046490"/>
    <dbReference type="eggNOG" id="KOG0465">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_1"/>
    <dbReference type="InParanoid" id="B8MJJ5"/>
    <dbReference type="OMA" id="GQFAKVQ"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="PhylomeDB" id="B8MJJ5"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04091">
        <property type="entry name" value="mtEFG1_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000003">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000022">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000015">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000558">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047872">
        <property type="entry name" value="EFG_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009381">
        <property type="entry name" value="PRK12740.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636:SF2">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="1">
        <location>
            <begin position="1"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000385585" description="Elongation factor G, mitochondrial">
        <location>
            <begin position="10"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="103"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="112"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="187"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="241"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="804" mass="89606" checksum="1E87D6145CA5F2D1" modified="2009-03-03" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJU8</accession>
    <name>B8MJU8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Allantoate permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_042400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484718.1">
        <property type="nucleotide sequence ID" value="XM_002484673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJU8"/>
    <dbReference type="GeneID" id="8103333"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_042400"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_6_1"/>
    <dbReference type="InParanoid" id="B8MJU8"/>
    <dbReference type="OMA" id="SRPGMYI"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="PhylomeDB" id="B8MJU8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF23">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="65"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED14765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="679" mass="75176" checksum="346C01C335821905" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJW9</accession>
    <name>B8MJW9_TALSN</name>
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        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">TSTA_042610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484739.1">
        <property type="nucleotide sequence ID" value="XM_002484694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJW9"/>
    <dbReference type="GeneID" id="8103353"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_042610"/>
    <dbReference type="HOGENOM" id="CLU_1175772_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJW9"/>
    <dbReference type="OrthoDB" id="4216319at2759"/>
    <dbReference type="PhylomeDB" id="B8MJW9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED14786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="242" mass="27952" checksum="098AA9E4DA116C6E" modified="2009-03-03" version="1">MAFNRTMATPPTYYRAILPHGASFAIKPEQFASENLERKYRVQKSIIRHSSLHCFCLYCYQGFARMEDLYRHASDSGEGHSQILRENRNREPRGFYNFFREALNLTEAHIDDWTICHMRIPDLFDPAILMELLKTKKGYESAIALQEAIIMATSLRATCPICYRSFSLHATLKTHFRDHGSEEHTKLLAEPDGRFDTGRVITEVVNSAWNPTGNVFLIEPQMRTSTTVYNVITGETRVRIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MK79</accession>
    <name>B8MK79_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_046860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485187.1">
        <property type="nucleotide sequence ID" value="XM_002485142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MK79"/>
    <dbReference type="FunCoup" id="B8MK79">
        <property type="interactions" value="533"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MK79"/>
    <dbReference type="GeneID" id="8108050"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_046860"/>
    <dbReference type="eggNOG" id="KOG1304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009646_3_1_1"/>
    <dbReference type="InParanoid" id="B8MK79"/>
    <dbReference type="OMA" id="QESMKQP"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="PhylomeDB" id="B8MK79"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990818">
        <property type="term" value="P:L-arginine transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089708">
        <property type="term" value="P:L-histidine transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089707">
        <property type="term" value="P:L-lysine transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000067">
        <property type="entry name" value="Transmembrane domain transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF666">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="568"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="612"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="658"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="681"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="717"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="354"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="319"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="9"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED15234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="753" mass="82056" checksum="A12319B4CFC5FCBB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKB5</accession>
    <name>B8MKB5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Small nucleolar ribonucleoprotein complex subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_047210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485223.1">
        <property type="nucleotide sequence ID" value="XM_002485178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKB5"/>
    <dbReference type="FunCoup" id="B8MKB5">
        <property type="interactions" value="1015"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MKB5"/>
    <dbReference type="GeneID" id="8098514"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_047210"/>
    <dbReference type="eggNOG" id="KOG0299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014017_1_0_1"/>
    <dbReference type="InParanoid" id="B8MKB5"/>
    <dbReference type="OMA" id="CSLRIWK"/>
    <dbReference type="OrthoDB" id="189968at2759"/>
    <dbReference type="PhylomeDB" id="B8MKB5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039241">
        <property type="entry name" value="Rrp9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="228"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="270"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="320"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="484"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED15270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="645" mass="71548" checksum="2E0A77211D25F1F3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKD2</accession>
    <name>B8MKD2_TALSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_047360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485240.1">
        <property type="nucleotide sequence ID" value="XM_002485195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKD2"/>
    <dbReference type="GeneID" id="8099286"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_047360"/>
    <dbReference type="eggNOG" id="ENOG502STDS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121094_0_0_1"/>
    <dbReference type="InParanoid" id="B8MKD2"/>
    <dbReference type="OMA" id="LDVYHSG"/>
    <dbReference type="OrthoDB" id="3433659at2759"/>
    <dbReference type="PhylomeDB" id="B8MKD2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877563" evidence="1">
        <location>
            <begin position="19"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="146" mass="16306" checksum="79D718D1CAB73DA6" modified="2009-03-03" version="1">MIFKNLLLFTCLAYLGQSSPITESSSPETNITTSTDTEFLSTRSSDGVWLDVYHSGSCDSGWEQQPTSGWVWSGQCKTLEQNTYGARLGHNKKKWKECILKFWEGDNCHGHATTWPTFMSECIATANKQDGQFYLGNGAKSVMLIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKD3</accession>
    <name>B8MKD3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_047370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485241.1">
        <property type="nucleotide sequence ID" value="XM_002485196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKD3"/>
    <dbReference type="STRING" id="441959.B8MKD3"/>
    <dbReference type="GeneID" id="8099287"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_047370"/>
    <dbReference type="eggNOG" id="ENOG502SPEM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1267645_0_0_1"/>
    <dbReference type="InParanoid" id="B8MKD3"/>
    <dbReference type="OrthoDB" id="4812218at2759"/>
    <dbReference type="PhylomeDB" id="B8MKD3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED15288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="218" mass="25049" checksum="0301844D5DF6FDFD" modified="2009-03-03" version="1">MSYEVGLYRVMGSLEGIYSRSRYLHNFLPKRLTTKRSTGYERNRHRDMKHTSYTVLPALLITTLLLNPAQAIQCSSCEGPPTFQEEYRTNYMPKVIKTWYGLQVLAPDTPYVAVAGSDKLYFIDTRLDTETAKHVKQNIEMATIPREDGYISIDEIEVTAEVKNTAGETMFVFDPEYARVFFAEPMNRRNPDLKLPEPEPAGDWLVTYDLESIVETES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKK6</accession>
    <name>B8MKK6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_048050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485314.1">
        <property type="nucleotide sequence ID" value="XM_002485269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKK6"/>
    <dbReference type="STRING" id="441959.B8MKK6"/>
    <dbReference type="GeneID" id="8106987"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_048050"/>
    <dbReference type="eggNOG" id="KOG3386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090404_1_1_1"/>
    <dbReference type="InParanoid" id="B8MKK6"/>
    <dbReference type="OMA" id="PIPWRFS"/>
    <dbReference type="OrthoDB" id="73901at2759"/>
    <dbReference type="PhylomeDB" id="B8MKK6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF120">
        <property type="entry name" value="HIGH-AFFINITY COPPER TRANSPORTER CTRA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED15361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="189" mass="20565" checksum="47A8D70B0B39F0F5" modified="2009-03-03" version="1">MDMSGMSASSTSSSSSGMTMAMAMVFTNSHSTPLWSSTWTPTTSGQYAGTCIFLIILAIIGRCLMAFKAAMERRWLAIALDRRYVVVAGKKPDSILDKADPDTIKTGTLTCQGVDETVRVVRQVATETQPWRFSVDLPRAALAFVVAGVSYLLMLAVMTMNVGYFMSVLAGTFIGELAVGRYIVHWSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLP9</accession>
    <name>B8MLP9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Circumsporozoite protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_098780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485859.1">
        <property type="nucleotide sequence ID" value="XM_002485814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLP9"/>
    <dbReference type="STRING" id="441959.B8MLP9"/>
    <dbReference type="GeneID" id="8099706"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_098780"/>
    <dbReference type="eggNOG" id="ENOG502QUVP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038962_0_0_1"/>
    <dbReference type="InParanoid" id="B8MLP9"/>
    <dbReference type="OMA" id="NRIHDQL"/>
    <dbReference type="OrthoDB" id="2141239at2759"/>
    <dbReference type="PhylomeDB" id="B8MLP9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED13621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="37852" checksum="04DA98AAD6AE2284" modified="2009-03-03" version="1">MYSKTAFVYFLAAVAEARFGQEQGNGAIAAIQALSNLGQPGQAATLAGGSIQFLLAAANPCGKLIQADKIVSQLGTSDAAIAAARGLVAAEQNFNPFVVSIPSICSDPTLPTTAALRGVVPLIDPAVGGQDIENANSKTSVTTPFDATGLSVAQVMVAHGFSNFTAVAQDGTKVAASALGTSGASTGAASSAAVAVAASSSTVVNACSGPTTLATAVSSAAVATATPSAASAAAGTCTGSGSTLTCSAPAAGARAVSDPVTGTFGGFVASTIAGLDFGLCVPTMKFEAGLDGRSTSESTFQAIDPLINKGQEEAKNPLIIANRIHDQLTNVCGANAAAKSAAAAAQQKLASLGTKDASTADAWNTALGFAGTNTNPDNAPKAGLVGHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLV1</accession>
    <name>B8MLV1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_101170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486115.1">
        <property type="nucleotide sequence ID" value="XM_002486070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLV1"/>
    <dbReference type="GeneID" id="8101805"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_101170"/>
    <dbReference type="HOGENOM" id="CLU_2348116_0_0_1"/>
    <dbReference type="InParanoid" id="B8MLV1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED13877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="97" mass="11643" checksum="F16C98B1791287E6" modified="2009-03-03" version="1">MIQRKIKDGTLFESISDHLTSDMEDKFESFCKNVQDSLYKPFHMIIPDAQEKQKAEERFKEQLAEEVWRLKAKYLEIRFSMSKFWYLDTASGVRWGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8MM21</accession>
    <name>B8MM21_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_097890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485771.1">
        <property type="nucleotide sequence ID" value="XM_002485726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MM21"/>
    <dbReference type="STRING" id="441959.B8MM21"/>
    <dbReference type="GeneID" id="8108428"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_097890"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002055_0_1_1"/>
    <dbReference type="InParanoid" id="B8MM21"/>
    <dbReference type="OrthoDB" id="4850545at2759"/>
    <dbReference type="PhylomeDB" id="B8MM21"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="561"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1068" mass="122098" checksum="5084D00C68418633" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8MM26</accession>
    <name>B8MM26_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_097940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485776.1">
        <property type="nucleotide sequence ID" value="XM_002485731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MM26"/>
    <dbReference type="GeneID" id="8108433"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_097940"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1273019_0_0_1"/>
    <dbReference type="InParanoid" id="B8MM26"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="PhylomeDB" id="B8MM26"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF92">
        <property type="entry name" value="AGL026WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED13538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="217" mass="24107" checksum="8E929189FEFBD4FC" modified="2009-03-03" version="1">MDVRVWLFACLQMATRATISFSHFFPTLVQQIRFKDNTTVLLLTYPPYVVTFVWAICWAWVADSHQIRSMPGGVSQCCAILETILLIAVPGFWARYAFTFLASCGTFGVYATTYAWLSSAIIQPPVKRAAAIGLANICANIASLAQEDLDSADGAEVNTSTEKVMSKVKPTAVKKAASLIEKMQSGEDENQDLLRKMCHYLESTYREIKSLKETLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMA0</accession>
    <name>B8MMA0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-galactosidase</fullName>
            <ecNumber evidence="2">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_099090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485892.1">
        <property type="nucleotide sequence ID" value="XM_002485847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMA0"/>
    <dbReference type="STRING" id="441959.B8MMA0"/>
    <dbReference type="GeneID" id="8103987"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_099090"/>
    <dbReference type="eggNOG" id="ENOG502RCTR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051214_1_1_1"/>
    <dbReference type="InParanoid" id="B8MMA0"/>
    <dbReference type="OMA" id="EYSECET"/>
    <dbReference type="OrthoDB" id="2108802at2759"/>
    <dbReference type="PhylomeDB" id="B8MMA0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004352">
        <property type="entry name" value="GH114_TIM-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273">
        <property type="entry name" value="ALPHA-1,4 POLYGALACTOSAMINIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G07890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273:SF2">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03537">
        <property type="entry name" value="Glyco_hydro_114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside-hydrolase family GH114 TIM-barrel" evidence="3">
        <location>
            <begin position="123"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED13654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="360" mass="39807" checksum="36A9F7D72B4A3BBC" modified="2009-03-03" version="1">MDPLLILDLEKFQPRIMVAWPTVFGLTGYFAAVFETEDFLHNLKAAYPKTSIPDPDNPRTTTMMSDMVKIASTGQGSWSAIITTVIASIAVLASPTSGASSDSACNATTINSNTYWQPTAGTTWQIELLYKLNDTSVDVQVYDIDLFDTDADQISSLQAAGRKVICYFSAGSWENWRPDADQFNSADLGGDLDGWAGEKWLNISSDSVRKIMTARLNMASQKGCDGVDPDNVDGYSNKENALDLTQEQSIGYVNFLAKEAHSRNMAIGLKNAGDIIESVLDNMQWSVNEQCVQYGECDKYTPFTDANKPVFHIEYPKGEDVNNDKDVTDAQKKKACVFEGSEKFSTVIKNMDLDNWVQFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMA2</accession>
    <name>B8MMA2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenases/reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_099110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485894.1">
        <property type="nucleotide sequence ID" value="XM_002485849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMA2"/>
    <dbReference type="STRING" id="441959.B8MMA2"/>
    <dbReference type="GeneID" id="8103989"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_099110"/>
    <dbReference type="eggNOG" id="ENOG502SMMV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078552_0_0_1"/>
    <dbReference type="InParanoid" id="B8MMA2"/>
    <dbReference type="OMA" id="FAYRDTI"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="PhylomeDB" id="B8MMA2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03445)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED13656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="238" mass="25769" checksum="EB671589ADD3051D" modified="2009-03-03" version="1">METVLVVGATGNIGVAAILGALRAKRNVLAIVRNQVSADKLFQHVRSKDGITIVEADIMAEEGVQGVVEQVRAGKLPTFQHVYAAAGGAYGVTPLRDLSTSELRKFMSINFESNFLAYSATIPYLLEQSSSTSFTLCTGSQGDIGARAAPAITQGPLYSMANVACRDNENTNVRFNEVYLATRVEVDSVAEKTGAMKTSDFANVYNELLSRPDIKSSRITVATKNDLKDLKYKKKIDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MML8</accession>
    <name>B8MML8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Elongation factor 2 kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_100180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486010.1">
        <property type="nucleotide sequence ID" value="XM_002485965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MML8"/>
    <dbReference type="STRING" id="441959.B8MML8"/>
    <dbReference type="GeneID" id="8105461"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_100180"/>
    <dbReference type="eggNOG" id="ENOG502S4BB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077993_0_0_1"/>
    <dbReference type="InParanoid" id="B8MML8"/>
    <dbReference type="OMA" id="TSWARAM"/>
    <dbReference type="OrthoDB" id="4224470at2759"/>
    <dbReference type="PhylomeDB" id="B8MML8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17509">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051852">
        <property type="entry name" value="Alpha-type_PK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992:SF11">
        <property type="entry name" value="ALPHA-TYPE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00811">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-type protein kinase" evidence="6">
        <location>
            <begin position="45"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED13772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="268" mass="30359" checksum="511DBE356532E187" modified="2009-03-03" version="1">MTRVCARCQQELPKSSFTAYQYSLGRGVSCCVSCDNGYHSVTLYAGRSYSGRYNESGYATVDIRALRNPFAQGTFRWVAMGEYISGPREGRALSEDYFTLDIKAVDKALEIIDQFNRLRFMDKVIKVNIPQVWEFAYGLEEFTGQLFLCEPFIDNYQKFNSNSGWKDDSTSWARAMQALSHFSYHLSGGNHVLCDLQGGIRGDEVILTDPAILSRNGEYGITDTGPEGMVSFFSTHVCNEFCRPHWIRPNAPKQHFSPVPGTMMIPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMT2</accession>
    <name>B8MMT2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor SLU7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_100800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLU7 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486076.1">
        <property type="nucleotide sequence ID" value="XM_002486031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMT2"/>
    <dbReference type="FunCoup" id="B8MMT2">
        <property type="interactions" value="490"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MMT2"/>
    <dbReference type="GeneID" id="8097964"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_100800"/>
    <dbReference type="eggNOG" id="KOG2560">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019317_3_1_1"/>
    <dbReference type="InParanoid" id="B8MMT2"/>
    <dbReference type="OMA" id="KYAWESQ"/>
    <dbReference type="OrthoDB" id="249612at2759"/>
    <dbReference type="PhylomeDB" id="B8MMT2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030628">
        <property type="term" value="F:pre-mRNA 3'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021715">
        <property type="entry name" value="Slu7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039974">
        <property type="entry name" value="Splicing_factor_SLU7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942">
        <property type="entry name" value="STEP II SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11708">
        <property type="entry name" value="Slu7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor SLU7" evidence="9">
        <location>
            <begin position="111"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="143"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="394"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="394"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED13838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="461" mass="52921" checksum="650C6CA70FF5D268" modified="2009-03-03" version="1">MSRKPTDVASKERNEYIPSFIAKKPFYIDDESTDADYLEHQRLQKQAADSKWYERGKRAGPAATKYRKGACENCGAMTHKTKECLSRPRKLGAKWTGKDIQADEVVQDVDLGWDAKRDRWNGYDASEYRNVVEEYEELENLKKSAKKATGGDDEDDEEADQEEARYAEESDMGRKQSTATRNLRIREDTAKYLLNLDLDSAKYDPKTRSMIGLGAQADQTSALVAEENFIRASGDAAEFERAQKYAWESQERGDKQIHLQANPTSGEILRKREQAEMEAKREAQRKALLEKYGGEEHMKPAPLREAAVIENERFVEYDETGAIKGTPKKAVKSKYPEDILINNHKSVWGSWWYNFQWGYACCHSTVKNSYCTGEDGKKAFENARKFAILDTLKQDNEEEKREDEPSKQEEETRRVDIDKKKRDLHALQQGVDEEELESYKRSRLAAADPMAAFLGKDELIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPE1</accession>
    <name>B8MPE1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1445 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_105910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-glutamate cyclase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486618.1">
        <property type="nucleotide sequence ID" value="XM_002486573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPE1"/>
    <dbReference type="STRING" id="441959.B8MPE1"/>
    <dbReference type="GeneID" id="8100450"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_105910"/>
    <dbReference type="eggNOG" id="ENOG502QV7A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059759_1_0_1"/>
    <dbReference type="InParanoid" id="B8MPE1"/>
    <dbReference type="OMA" id="NVPMYKT"/>
    <dbReference type="OrthoDB" id="10262538at2759"/>
    <dbReference type="PhylomeDB" id="B8MPE1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047820">
        <property type="term" value="F:D-glutamate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006536">
        <property type="term" value="P:glutamate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2040.10:FF:000001">
        <property type="entry name" value="D-glutamate cyclase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1640.10">
        <property type="entry name" value="PSTPO5379-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2040.10">
        <property type="entry name" value="PSTPO5379-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009906">
        <property type="entry name" value="D-Glu_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038021">
        <property type="entry name" value="Putative_hydro-lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32022">
        <property type="entry name" value="D-GLUTAMATE CYCLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32022:SF10">
        <property type="entry name" value="D-GLUTAMATE CYCLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07286">
        <property type="entry name" value="D-Glu_cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160920">
        <property type="entry name" value="PSTPO5379-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED14380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="304" mass="33910" checksum="1C5E2E94FCBB5416" modified="2009-03-03" version="1">MHRSEIENLPTTPAHKARLLSRHNLVETTSGLAGDYIQANLIVLRAEYADDFRMLCARNPVPCPILGATPIGDPHRIMPTIPGVTLVDENDFDIRTDIPSYHTFRTVDCSKNGGKKKKVLIETKPTLLSDWTTEHIAFLIGCSFSFEQALTQQGLKICHQVQNKTVAMYRSSIPLLPAGIFHGSSFVVSMRLYRPEQLEEVRNVTRPYLATHGEPIAWGWEGARSIGVDDVGKVDYGDVQVVRDGEIPVFWGCGVTPQFAVEKALERNAISGTVMSHKPGQMLVTDWKITDFLEQTRKQLDLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQ48</accession>
    <name>B8MQ48_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin-activating enzyme E1 1</fullName>
            <ecNumber evidence="4">6.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_055740</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.45" evidence="4"/>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487185.1">
        <property type="nucleotide sequence ID" value="XM_002487140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQ48"/>
    <dbReference type="FunCoup" id="B8MQ48">
        <property type="interactions" value="1315"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MQ48"/>
    <dbReference type="GeneID" id="8102267"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_055740"/>
    <dbReference type="eggNOG" id="KOG2012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002556_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQ48"/>
    <dbReference type="OMA" id="GANLHAF"/>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="PhylomeDB" id="B8MQ48"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01491">
        <property type="entry name" value="Ube1_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01490">
        <property type="entry name" value="Ube1_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2660:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12550:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000015">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.180:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.60:FF:000002">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.180">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, FCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.60">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, UFD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032420">
        <property type="entry name" value="E1_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032418">
        <property type="entry name" value="E1_FCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042302">
        <property type="entry name" value="E1_FCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018965">
        <property type="entry name" value="Ub-activating_enz_E1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038252">
        <property type="entry name" value="UBA_E1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018075">
        <property type="entry name" value="UBQ-activ_enz_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01408">
        <property type="entry name" value="Ube1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16191">
        <property type="entry name" value="E1_4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16190">
        <property type="entry name" value="E1_FCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09358">
        <property type="entry name" value="E1_UFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00985">
        <property type="entry name" value="UBA_e1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-activating enzyme E1 C-terminal" evidence="13">
        <location>
            <begin position="898"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="775"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED13074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1030" mass="114785" checksum="D977F65BD953E5A9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQ62</accession>
    <name>B8MQ62_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS peptide transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_055880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487199.1">
        <property type="nucleotide sequence ID" value="XM_002487154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQ62"/>
    <dbReference type="GeneID" id="8102281"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_055880"/>
    <dbReference type="eggNOG" id="KOG1237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004790_4_3_1"/>
    <dbReference type="InParanoid" id="B8MQ62"/>
    <dbReference type="OMA" id="EKDIGYW"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="PhylomeDB" id="B8MQ62"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED13088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="605" mass="65509" checksum="91FA6792E5BC42D4" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQ98</accession>
    <name>B8MQ98_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_057360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487356.1">
        <property type="nucleotide sequence ID" value="XM_002487311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQ98"/>
    <dbReference type="STRING" id="441959.B8MQ98"/>
    <dbReference type="GeneID" id="8108872"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_057360"/>
    <dbReference type="eggNOG" id="ENOG502RXFG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1462272_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQ98"/>
    <dbReference type="OrthoDB" id="3445803at2759"/>
    <dbReference type="PhylomeDB" id="B8MQ98"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED13245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="185" mass="20833" checksum="609CCA799CB4CD34" modified="2009-03-03" version="1">MRQWIDLCVRTHRLIRANPAFDRMKISGPTLAADPHNTNIWIAGNNTIPNQIEYRLEAGPGTGTSQSAYDLTNAYPSVVAMLRSYGIPERPQIINDYASFQEQIPFGAAFWISQLKRYNTHALRGNWQGGNTLHDLMANLLTKSDPFKYTATGYMPGPKYTVYQNYYKNMTGVRVDNTGGDKPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQQ0</accession>
    <name>B8MQQ0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C6 finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_059600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487584.1">
        <property type="nucleotide sequence ID" value="XM_002487539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQQ0"/>
    <dbReference type="STRING" id="441959.B8MQQ0"/>
    <dbReference type="GeneID" id="8107429"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_059600"/>
    <dbReference type="eggNOG" id="ENOG502SIT5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021599_4_0_1"/>
    <dbReference type="InParanoid" id="B8MQQ0"/>
    <dbReference type="OMA" id="KCTETRV"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="PhylomeDB" id="B8MQQ0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF10">
        <property type="entry name" value="C6 FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="54291" checksum="1678870EB3D792AC" modified="2009-03-03" version="1">MEMVHAPSRIISANATTTEERENENEKLRQLKTRGRKPRAKNPKRYTEDVDTIAIVRRHGANNNYLAMDEYLNPSLAAQTTSTQHIQVFVDYIMVAWPCLFKCTERSVPISWVTYAASRGSGTDTNSFDLGLRSLTCSFMGASSHDQRLINAGRQLYASKLSNLQYTSFKEGGILDEDILAAAVVLSVYEMYNGSTASAWLYHHSGIVEMMRLRGAEAHTTGFGRAIYIAYRGFIITASLLKGEACFLEQKEWQSMSERLATENAKQPDSSVFNEIAERAFREMVKLPGMLKRVRDLWETPPVNQFLVRPQLKQELAALRAALRGLHTELGITVSTHGGPDNPSALVANVDRKKKDIFVGPVSCMFFDGFSALTIRGIRSGIVLVDQLLFLLTPETKVRQMLDEEINTLSREDDLTQNFVDNVRKDPSPSPFFMIDTSTRPFPIRIESLMDPRLRQGPNTSWTDRIATSYGMLGVRIHVDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQW0</accession>
    <name>B8MQW0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetyltransferase family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_053130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486906.1">
        <property type="nucleotide sequence ID" value="XM_002486861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQW0"/>
    <dbReference type="STRING" id="441959.B8MQW0"/>
    <dbReference type="GeneID" id="8098262"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_053130"/>
    <dbReference type="eggNOG" id="ENOG502RD0D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049918_2_0_1"/>
    <dbReference type="InParanoid" id="B8MQW0"/>
    <dbReference type="OMA" id="FTIINYY"/>
    <dbReference type="OrthoDB" id="10260017at2759"/>
    <dbReference type="PhylomeDB" id="B8MQW0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053710">
        <property type="entry name" value="Arylamine_NAT_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF0">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01543">
        <property type="entry name" value="ANATRNSFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED12795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="330" mass="37824" checksum="A421E668232CE300" modified="2009-03-03" version="1">MGSTVDWSQRPTYSPEQLDKYFDRIKLPAKYWQSPIVQNGASSDNEAALSFLKVLERYQVAAVPFENLNLHYSVQRHISIDAQKLFEKIVDSKSERGGYCMENSTLFGTVLRSLGYQVTSVGGRVNEAAQPMSASKNWRGPKYDGWNHMVNIVSIGEQKYLIDVGFGSNGPHQPVPLTWDFEFHNVGDQSGRLRYGPITQHTNKTEQQHLWQYEIRNGNTDWIPAYCFTETEFIPEDFTMMNYYMSTSRDSWFTFHIVCVRMLLDEAGENVVGDLTLFNNSLKRRIGATSEVMQIFSTDEERVSALDKTFNIRIGPADRDSIRHTISEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRJ5</accession>
    <name>B8MRJ5_TALSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_056330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487243.1">
        <property type="nucleotide sequence ID" value="XM_002487198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRJ5"/>
    <dbReference type="GeneID" id="8100696"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_056330"/>
    <dbReference type="eggNOG" id="ENOG502SRG9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_443511_0_0_1"/>
    <dbReference type="InParanoid" id="B8MRJ5"/>
    <dbReference type="OMA" id="HESTFET"/>
    <dbReference type="OrthoDB" id="5404794at2759"/>
    <dbReference type="PhylomeDB" id="B8MRJ5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="554" mass="60867" checksum="615D6F1829861E73" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MS94</accession>
    <name>B8MS94_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinesin light chain, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_002900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487881.1">
        <property type="nucleotide sequence ID" value="XM_002487836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MS94"/>
    <dbReference type="STRING" id="441959.B8MS94"/>
    <dbReference type="GeneID" id="8102901"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_002900"/>
    <dbReference type="eggNOG" id="KOG1840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_485857_0_0_1"/>
    <dbReference type="InParanoid" id="B8MS94"/>
    <dbReference type="OMA" id="NIRICLM"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="PhylomeDB" id="B8MS94"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="477"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED12227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="561" mass="62272" checksum="D1D705777D478901" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MST3</accession>
    <name>B8MST3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Valacyclovir hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_006390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488269.1">
        <property type="nucleotide sequence ID" value="XM_002488224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MST3"/>
    <dbReference type="STRING" id="441959.B8MST3"/>
    <dbReference type="ESTHER" id="talsn-b8mst3">
        <property type="family name" value="Fungal-D14-Strigolactone-R"/>
    </dbReference>
    <dbReference type="GeneID" id="8105324"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_006390"/>
    <dbReference type="eggNOG" id="ENOG502SD5P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_49_0_1"/>
    <dbReference type="InParanoid" id="B8MST3"/>
    <dbReference type="OMA" id="PWGFELS"/>
    <dbReference type="OrthoDB" id="294702at2759"/>
    <dbReference type="PhylomeDB" id="B8MST3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45763:SF46">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45763">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="28"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="298" mass="32398" checksum="7225FEEC3B14402D" modified="2009-03-03" version="1">MPQQFQQFQLPDGRNLDYCVNGPEDGIPLVWLHGTPSAGIPAPNLVTACAKKGIKVIALSRPGYGGSSRNKGRQVVDTVADIKSLLNHLGVKKCLVGGWSGGGPLTLACAARLPTCLAAVSFAGVGPYGVEGLDWWVGQGEDNVEEFSQALKGEPQLRQFCESHRKEFLQSDLDGVMEAMSTLLPPCDNATLIQNRDTIGQNMIDMLQEGLKHNADGWVDDDLELLKPWGFELSEIRVPVVLLQGTEDKMVPFGHGKWLAEHLPQDKVKAHLLEGHGHISIFEGIDRIIDELIAVANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2024-01-24" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSZ4</accession>
    <name>B8MSZ4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_002170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487804.1">
        <property type="nucleotide sequence ID" value="XM_002487759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSZ4"/>
    <dbReference type="STRING" id="441959.B8MSZ4"/>
    <dbReference type="GeneID" id="8102828"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_002170"/>
    <dbReference type="eggNOG" id="ENOG502QT2T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2086401_0_0_1"/>
    <dbReference type="InParanoid" id="B8MSZ4"/>
    <dbReference type="PhylomeDB" id="B8MSZ4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022124">
        <property type="entry name" value="DUF3659"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12396">
        <property type="entry name" value="DUF3659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED12150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="117" mass="12567" checksum="AD4BC63BD252A463" modified="2009-03-03" version="1">MEGGSYSLLHGLEMGTDGLIFDKFNELAGEVVEGDLEYVAGCVINEYNKILDIDGAVVGHAEVISPTPAQKARHPAPKKIFDSLEEEVSRFGHRLQPSIGTVDGFHAGCLGFDGCFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8MT50</accession>
    <name>B8MT50_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Quinone oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_003150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487907.1">
        <property type="nucleotide sequence ID" value="XM_002487862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MT50"/>
    <dbReference type="STRING" id="441959.B8MT50"/>
    <dbReference type="GeneID" id="8098011"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_003150"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_0_1"/>
    <dbReference type="InParanoid" id="B8MT50"/>
    <dbReference type="OMA" id="NEGHNTT"/>
    <dbReference type="OrthoDB" id="3233595at2759"/>
    <dbReference type="PhylomeDB" id="B8MT50"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF5">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="8"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED12253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="373" mass="39876" checksum="FA193D18D48434B4" modified="2009-03-03" version="1">MKEVIVSPTLPEVTARVQDGPIPSIGPDEILVKVVIAASNPKDYRHLYITQKSVNSGDDVAGYVSSIGKDVKTTGEFRIGDRVAGFHKMLLPGGAYAEYAVVPAHTAFIIPDNILFEEASTIPLTILAAALPLFRRQNLPAPWIGRSKNAEPLPLIVYGASSALGTFAIKLALLANIHPIIAICGATKSGLTSLLKSELGDTIVDYRPGVDAMKTAVKEALNGLKSYHALDAISENDSWIPISQLLSPGGHLSVVQGGPPDKYSKPSIPTEVNIGYTYVGSAHYGAFNSSMLNQPADKDSVVKDIDFAYVLMRYVARELANGNLSGHPWEVISGGLEGVESGLRKLQHGEAKGVKYIYRIAETRGVTSESDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTA4</accession>
    <name>B8MTA4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_004060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488008.1">
        <property type="nucleotide sequence ID" value="XM_002487963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTA4"/>
    <dbReference type="STRING" id="441959.B8MTA4"/>
    <dbReference type="GeneID" id="8106834"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_004060"/>
    <dbReference type="HOGENOM" id="CLU_2361159_0_0_1"/>
    <dbReference type="InParanoid" id="B8MTA4"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="PhylomeDB" id="B8MTA4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="96" mass="10559" checksum="2BBA45E40821FB9F" modified="2009-03-03" version="1">MLTAGKRKGDNGYFIAPTIFLNFPDDNDVVTKEILGPLSPSSLSRLRKLLSEPTTPSLFSSFFTRDIFRALPIAKQHKSGTVTINCTSLPSPRYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTG4</accession>
    <name>B8MTG4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_003540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487950.1">
        <property type="nucleotide sequence ID" value="XM_002487905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTG4"/>
    <dbReference type="GeneID" id="8098050"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_003540"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="InParanoid" id="B8MTG4"/>
    <dbReference type="OMA" id="QTIFYTM"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="PhylomeDB" id="B8MTG4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF156">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="542"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="71"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED12296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="577" mass="62496" checksum="D2939B57DF505B75" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MU34</accession>
    <name>B8MU34_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_006840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488321.1">
        <property type="nucleotide sequence ID" value="XM_002488276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MU34"/>
    <dbReference type="STRING" id="441959.B8MU34"/>
    <dbReference type="GeneID" id="8105369"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_006840"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_943917_0_0_1"/>
    <dbReference type="InParanoid" id="B8MU34"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="PhylomeDB" id="B8MU34"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050665">
        <property type="entry name" value="Cytochrome_P450_Monooxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282">
        <property type="entry name" value="CYTOCHROME P450 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282:SF211">
        <property type="entry name" value="CYTOCHROME P450-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED12667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33152" checksum="3524E3560ACC1828" modified="2009-03-03" version="1">MGPPNHTLADRVIGHNRAQQAYSESCSQNSHKEILREIQSLRISITTPDPTKDPSYADVACTPPTRQLSNIWILSLFHTTLTTITDTLYCTIDTSKMADDESNRMSAGSIRTAVEKEIRNMENHMNWRCRAVTVDPKNTNRIRIACRDEAEHQLVKKVAEAKIGAGARVLRDELYPIKVTSLAVCNHAFHHNPAVWGEDHSIFNPCRWDDPTIATKSRLLMHFGLCGRQCIGKTVATTNIYKLLSTLLRQFEFELASDLERMNVAKGLYKGQIPEMVSVGISDLKGPLLVKAKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MU38</accession>
    <name>B8MU38_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_006880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488325.1">
        <property type="nucleotide sequence ID" value="XM_002488280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MU38"/>
    <dbReference type="STRING" id="441959.B8MU38"/>
    <dbReference type="GeneID" id="8105373"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_006880"/>
    <dbReference type="eggNOG" id="KOG1269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_1_2_1"/>
    <dbReference type="InParanoid" id="B8MU38"/>
    <dbReference type="OMA" id="WASNIAD"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="PhylomeDB" id="B8MU38"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF105">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="44048" checksum="CAC604F97885DBDC" modified="2009-03-03" version="1">MATGFLTPRRQGSFLRNDSSASKESFSDNLSTNVLASPLQAYKYENNRRYHAYREGSYWGPNDEQDAYHQRVAHHLFTLVLQDRLYLAPISSPRHVLDVGTGIGLWASNIADANPAAQVLGTDLSPIWHDDATIRPNLTFEVDDCCSNWTYLDEGRELFDLVHIRCLYGSIKDWRKLYQQAFDHLEPGKGYIEQVELSLIPRFWYTNTADEGAGNDYCSLDLESTSHTEELNSIFATWYKFWQECSRQTGKTWFVADQMAGLIYETGFDNVREIRYILPLFDCLEGMTSITTEGTTSIGEELMGGYSDYPVPRLQEIARWFRQFWETGMEGWVLAVSTRYMGWTADEAKEFVAETKRVLVEQESRVYYELVVIYGQRPSDSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MU54</accession>
    <name>B8MU54_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposable element tc3 transposase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_109510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488528.1">
        <property type="nucleotide sequence ID" value="XM_002488483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MU54"/>
    <dbReference type="STRING" id="441959.B8MU54"/>
    <dbReference type="GeneID" id="8107183"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109510"/>
    <dbReference type="eggNOG" id="ENOG502QUTZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033666_0_1_1"/>
    <dbReference type="InParanoid" id="B8MU54"/>
    <dbReference type="OMA" id="FWPAFSS"/>
    <dbReference type="OrthoDB" id="4349822at2759"/>
    <dbReference type="PhylomeDB" id="B8MU54"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052338">
        <property type="entry name" value="Transposase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022:SF119">
        <property type="entry name" value="TC1-LIKE TRANSPOSASE DDE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022">
        <property type="entry name" value="TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13384">
        <property type="entry name" value="HTH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="2">
        <location>
            <begin position="232"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED11772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="337" mass="39200" checksum="F354EF12DB935A04" modified="2009-03-03" version="1">MATPEPTSPPRATSAGVLEPSDPRQNSARLNRDERIRVLTLRDAGFTYLQISQQLQISYRQVQYTCQSQQATPKKARGNPPKLSEAEVDHIIEWITSSKRTQRMPYYKVIQELNLSIGKHALARALKKRGYTRCKALNKPPLSDKHKQVTSGFHTRIWVTRKAGEELEETCIRSSPTRKRGWMFWATFHGNNKGPCLFWEKEWGTINSERYCQRVIPIIDGYIRLLRDDIWLQFMQDGAPGHASKETLEELHSRGIYPIFWPAFSSDLNPIEAVWNWMKDWIQEQYPDDEQLSYDRLREVVRAAWDALPEQFLKELIDSMHARCQAVIDARGGHTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8MU58</accession>
    <name>B8MU58_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 8">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_109560</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 8"/>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488532.1">
        <property type="nucleotide sequence ID" value="XM_002488487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MU58"/>
    <dbReference type="STRING" id="441959.B8MU58"/>
    <dbReference type="GeneID" id="8107188"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109560"/>
    <dbReference type="eggNOG" id="KOG1494">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1797753_0_0_1"/>
    <dbReference type="InParanoid" id="B8MU58"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="PhylomeDB" id="B8MU58"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="9">
        <location>
            <begin position="7"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="87"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED11776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="144" mass="15793" checksum="519FC2E124247BFA" modified="2009-03-03" version="1">MVKGRYGLVRKPRMTRDDRFEANAGIVRSLVKGIAEFSPKAFVLIVSNLVNSTVAGVFDPKRLFGVTTLDVVRAETFVQEYTRPAFEIPADKYDALVNSVQFSGGEVVKAKDGAASATFSMAYAGFRFVESVIKALNQRYGVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUE9</accession>
    <name>B8MUE9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_109680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488544.1">
        <property type="nucleotide sequence ID" value="XM_002488499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUE9"/>
    <dbReference type="STRING" id="441959.B8MUE9"/>
    <dbReference type="GeneID" id="8107200"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109680"/>
    <dbReference type="eggNOG" id="ENOG502S0H3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_26_0_1"/>
    <dbReference type="InParanoid" id="B8MUE9"/>
    <dbReference type="OrthoDB" id="4357294at2759"/>
    <dbReference type="PhylomeDB" id="B8MUE9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="151"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="453" mass="50082" checksum="A6A6EA65D1147E41" modified="2009-03-03" version="1">MAQKPGGQDISNRVGEHLEKLTKVILTGARAVLPVFRTTPKPVLYRESGFSPPEIELDRIALLATVRLRRLDPYHPLRRRAEQIASNGRQISRFARRTLALPNSEQINPLQYAPWYPREPRGNAQARIGAPMGRTKEQAAANFMAFQRTIPSSDIVIFSDGSRLADGRAGGGYIGLQAHHQFLRSSLSYGHGKEVFDAEAEAALAGAQAAIAYPTAQFATNLWICLDNLEVAIRLLSPSTGSSQEIFESFRTLAAAWPLRKRLPHTKSGSIQIRWVPGHAKIPENEAADLAAKEGAASIPPDPHKSSYASLKRYAKTQSLSAAQSQWEKVAPQSYQDLEITTSPKRPGELQLNRLDLGHVIAARTGHGDFADYHERFNHDDAYLLCRCGARKAPLHFFFCHIAKRRAPRPPGPPSEVISFLLGTAKGAQKLASWLAETHFYEDICPRQPLLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUH4</accession>
    <name>B8MUH4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_110260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488602.1">
        <property type="nucleotide sequence ID" value="XM_002488557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUH4"/>
    <dbReference type="STRING" id="441959.B8MUH4"/>
    <dbReference type="GeneID" id="8107258"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_110260"/>
    <dbReference type="HOGENOM" id="CLU_1518850_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUH4"/>
    <dbReference type="OrthoDB" id="4471361at2759"/>
    <dbReference type="PhylomeDB" id="B8MUH4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="54"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="54"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED11846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="177" mass="21098" checksum="CB1CC2C92DA2CAAB" modified="2009-03-03" version="1">MERSHKSRTNTQYSFKIKKPLGSTSKYPYEKARQWVNRSPEQRQQEVAERNGKITRPLNAFMLYRMDNASYIRENIEGGLSWALEPKKVKEIYADLALEDQIRHVEAHPEYKLTQRKFAKTEIQDSERWESALFKHMDGHSHRQTEFYNPSELDFPLFTSPLFQLTDEDWDNSGYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUN9</accession>
    <name>B8MUN9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_108880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488463.1">
        <property type="nucleotide sequence ID" value="XM_002488418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUN9"/>
    <dbReference type="STRING" id="441959.B8MUN9"/>
    <dbReference type="GeneID" id="8103144"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_108880"/>
    <dbReference type="eggNOG" id="ENOG502SVBM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_638063_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUN9"/>
    <dbReference type="OMA" id="KKWHNAR"/>
    <dbReference type="OrthoDB" id="4526357at2759"/>
    <dbReference type="PhylomeDB" id="B8MUN9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="430" mass="46771" checksum="9D4FFFE50EF17CAB" modified="2009-03-03" version="1">MARNRSEPDKRSLQTVLQETTTAATTRAAEGQKIFSPIAAFLDKHRNQTAGLSPHLQGALATLSDNLATVAQHHFNAYISGITPTSSIHSPAPALSPIPSPLPPMPPSSRPPSGLAQSSYATITKSNPARSGTTIKQIKPPTKKPTPDVKQSLPDYRLFVRLSIDHAAKMMDSYTIYTSLWAQLGINSNALKEVQTTKTGFALCPATMEALSTLEAQKEVISTVTNLPRKIGQITNGQYSMIPVDPAILSTEIAEQTGYRPISVSETTASAANVNSPSSSWFINFSEDSKASLLTRLRLFGTITNARFLTRKKWHNARSCARSPRCRLCSSSEHIEEEHNNSLEIRKTCAINLAKARTEQGCSSESSATTQEQHMVIDTPPTQIQVASPFRPTTPPPLAPSQEPPVTASVVRFATPKPQNRFNSLLEEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUZ2</accession>
    <name>B8MUZ2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polymerase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_110130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488589.1">
        <property type="nucleotide sequence ID" value="XM_002488544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUZ2"/>
    <dbReference type="STRING" id="441959.B8MUZ2"/>
    <dbReference type="GeneID" id="8107245"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_110130"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_3_1_1"/>
    <dbReference type="InParanoid" id="B8MUZ2"/>
    <dbReference type="OrthoDB" id="4368687at2759"/>
    <dbReference type="PhylomeDB" id="B8MUZ2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="200"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="308" mass="35590" checksum="14B3D1167AA3DF45" modified="2009-03-03" version="1">MVLTPRDPNILVTKPPREDISSSHPITTSLFNDMRQKRREWTRTIEKLSVFVGRERFYKKGPKRATLWKAAIYMRPRDSYTNIPPLKVGSEEVTENNAKARVFLEIFFPKMADPEKEDLVLPLEKIPWHPITELEVYWSLKATKRMTAPGEDEIITLVWKHLWPYLWKVITYIFTKSVELGYYPHRWKRARIIVLRKSGKPDYGSPEAYRPISLLNTLGKVLEAVMARRLSFWAESYKLLPDTQFGGRPGRNTEQALLTLANAIDRAWLQSKVITLVAFDLKGAFNGVNDSSLDAHLQAKGIPTVARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8LSY3</accession>
    <name>B8LSY3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA-splicing endonuclease subunit Sen34</fullName>
            <ecNumber evidence="5">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_064460</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="5"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340366.1">
        <property type="nucleotide sequence ID" value="XM_002340325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LSY3"/>
    <dbReference type="FunCoup" id="B8LSY3">
        <property type="interactions" value="141"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LSY3"/>
    <dbReference type="GeneID" id="8100226"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_064460"/>
    <dbReference type="eggNOG" id="KOG4133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049366_0_0_1"/>
    <dbReference type="InParanoid" id="B8LSY3"/>
    <dbReference type="OMA" id="RTFSLEW"/>
    <dbReference type="OrthoDB" id="48041at2759"/>
    <dbReference type="PhylomeDB" id="B8LSY3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000008">
        <property type="entry name" value="tRNA-splicing endonuclease subunit Sen34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016690">
        <property type="entry name" value="TSEN34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059049">
        <property type="entry name" value="TSEN34_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00324">
        <property type="entry name" value="endA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26577">
        <property type="entry name" value="TSEN34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017250">
        <property type="entry name" value="tRNA_splic_SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TSEN34 N-terminal" evidence="9">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="8">
        <location>
            <begin position="205"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="108"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00059865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR017250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED22979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="346" mass="38400" checksum="BD725898E44ECA78" modified="2009-03-03" version="1">MAAEVPLPIPISFVSGRYLIFSADAATYLRREYNICGVLMGTLPHVPQQNVFLGIPLELMPEEARLLVEKKVARIIDTRRYHNESMRSLAEADKIKYLQTLQREGRSVSLAMSNRKEQQREESLRKAAQKRKAKASSTQKEEEEAAKNTDDMLFEPPPRPASSLSSSSSSVQSSTISITPATTCPLLPYQPAEEYDMPLPEVPASYPVFAHLHSHGYFLSPGLRFGCQYMAYPGDPLRFHSHFLVYGFHRDQELNLMEIVSGGRLGTGVKKGFLLGHAVDPGDPSSEVRTFSIEWAGIRELEACSLLPDNALCAWTTGLQCSTSSFAIASPKHCLYTLSEAVYAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8LSZ8</accession>
    <name>B8LSZ8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_064600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340381.1">
        <property type="nucleotide sequence ID" value="XM_002340340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LSZ8"/>
    <dbReference type="STRING" id="441959.B8LSZ8"/>
    <dbReference type="GeneID" id="8105122"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_064600"/>
    <dbReference type="eggNOG" id="ENOG502SS74">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1012583_0_0_1"/>
    <dbReference type="InParanoid" id="B8LSZ8"/>
    <dbReference type="OrthoDB" id="5356476at2759"/>
    <dbReference type="PhylomeDB" id="B8LSZ8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="275" mass="30408" checksum="03791A6236E7D71A" modified="2009-03-03" version="1">MAGARSTVPPFHLVLHNSFDIPAEYHERLQDNRLKEVTLKGDVHPNEHYLSLLNLSSGMTVSIPRLSQSIFKLNLGYFTWGFPIGFLSTLGERLPDLKCLRLYRQNVTGPNAETRRDAQQFLYLIPDLVDLYLSDVHGDPDFFVGLGKAFRRPGQRGLVILHVEYTFEVDIHDFILKLPIPELRELIHPAIVDLNFNMNPKASKPRGIVPWPPSGTPVNIGAAENGANDPQGAILTPSGDQNGTPRFSSGYPLGYLNSLPDVTVGEDCGNTVNAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8LT58</accession>
    <name>B8LT58_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Carnitinyl-CoA dehydratase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_069810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340953.1">
        <property type="nucleotide sequence ID" value="XM_002340912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LT58"/>
    <dbReference type="STRING" id="441959.B8LT58"/>
    <dbReference type="GeneID" id="8102623"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_069810"/>
    <dbReference type="eggNOG" id="KOG1680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_1"/>
    <dbReference type="InParanoid" id="B8LT58"/>
    <dbReference type="OMA" id="GFAGISQ"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="PhylomeDB" id="B8LT58"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000074">
        <property type="entry name" value="Enoyl-CoA hydratase (AFU_orthologue AFUA_2G10650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF68">
        <property type="entry name" value="CARNITINYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED23566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="284" mass="30918" checksum="ECC412E5F9CAC269" modified="2009-03-03" version="1">MTDLQTQPPSSQYYVLTFPAPHVLLVTINRENHRNALNHQAHWDAEAIFRWFDNETSLRVAIVTGKGSKAFCAGQDLIEQSNNVASKDGGIGAKRSERLLSHPPGGFMGLSRRRGKKPVIAAVNGYALGGGFEICLNCDIIVASPTATFGLPEAQVGLYAAAGGLSRLTRISGLQIASEIAMTNRKLTATEAQQYLLVNKISKSPETLIDEAVEMAIKISNLSPDSIIVTRHGIREAWETGNVEQATIRTQQEYTEKLFGGENFAIGVNAFANKTRPKWVPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTE6</accession>
    <name>B8LTE6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AP-3 adaptor complex subunit beta, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_064870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340411.1">
        <property type="nucleotide sequence ID" value="XM_002340370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTE6"/>
    <dbReference type="FunCoup" id="B8LTE6">
        <property type="interactions" value="465"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LTE6"/>
    <dbReference type="GeneID" id="8102491"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_064870"/>
    <dbReference type="eggNOG" id="KOG1060">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006320_3_2_1"/>
    <dbReference type="InParanoid" id="B8LTE6"/>
    <dbReference type="OMA" id="HFLVRST"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="PhylomeDB" id="B8LTE6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026740">
        <property type="entry name" value="AP3_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037096">
        <property type="entry name" value="AP3_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="40"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="556"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="695"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="759"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="590"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="708"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="762"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="774"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED23024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="830" mass="92296" checksum="A141F4368B35FC1E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTV6</accession>
    <name>B8LTV6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_071820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341173.1">
        <property type="nucleotide sequence ID" value="XM_002341132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTV6"/>
    <dbReference type="GeneID" id="8107638"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_071820"/>
    <dbReference type="HOGENOM" id="CLU_1284035_0_0_1"/>
    <dbReference type="InParanoid" id="B8LTV6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED23786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="215" mass="24188" checksum="36EDF5A6F982DD88" modified="2009-03-03" version="1">MPDTPLSLPKLNMGNDAVISQVQTDPPPKYLDMSTGVSNPALEHFIYIPQPPLYEYGATVYTHIAHRSWPSEFPPQLEYDCVGVQRPTEGLTERRKRQNRLAQRRYRVRQEQRAVLLNDKVAGLEQRIQSIRELCLDVLKNSGLLGYYSSDTLLSTLQSLLSLTDPERLRLENHNPYFDLGVQSLADLLHREARCAAPEGQLVACASVSSKSDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTZ3</accession>
    <name>B8LTZ3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_072160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341210.1">
        <property type="nucleotide sequence ID" value="XM_002341169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTZ3"/>
    <dbReference type="GeneID" id="8104421"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_072160"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_638061_0_0_1"/>
    <dbReference type="InParanoid" id="B8LTZ3"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="PhylomeDB" id="B8LTZ3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF27">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED23823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="430" mass="47320" checksum="E1C9326B68B81218" modified="2009-03-03" version="1">MGKGIYSFITSTVHHVPTLPRSGANAADTLGLNHLSLRQSFSVRLALAVLLIAQFSFGFDQQGYSSTQAMASFKNQFGSYNAKMKKYTLDTLHILGAGRRYGGRMCMFCMSIRAIICATIPHHPEDVRPDFGWSCAKLIGIPTDIYIGMELSVVSIFQSEIVPSHACGFVVGTYQSSSYRKAYMIPYGLFYLVPTPVVTLIWFIPEENSSFLDIFRGSNLRRTLVVCGTNFFLQSTGQISTSLYGALFVSDLGTVSPFIVTVIIAISNLTASGIAMILTDRIGRRALILIGASIQVTSQMTMGSLGNANPFTKSEKAGVVAMMVTRLWIQCWLGSRCTYSQCRISQQSGSRYDLSNCFGPQHCRVSAFIFASIAFVSIGIRTSFQMLLGGHWRKSTSCLRATPHCGSLQKLNFGVKETILRINKHEIQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8LU56</accession>
    <name>B8LU56_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_060250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002339915.1">
        <property type="nucleotide sequence ID" value="XM_002339874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LU56"/>
    <dbReference type="STRING" id="441959.B8LU56"/>
    <dbReference type="GeneID" id="8103968"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_060250"/>
    <dbReference type="eggNOG" id="ENOG502SSJ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000907_3_2_1"/>
    <dbReference type="InParanoid" id="B8LU56"/>
    <dbReference type="OMA" id="WIDSGRN"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="PhylomeDB" id="B8LU56"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="3"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="129" mass="14206" checksum="201A7D4087ED02F6" modified="2009-03-03" version="1">MDCNSVEGIIGYTFNDRELLAKALHQTQNKRLALLGDKVVALVLIDSWYQTGTSCSAGSSLLQHSASNEAMAHQEDKTHLKDTVCLNSHQAQSIHGLATNFEAVVGAVWIDCGKDLQTLEKVIRQLYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUA1</accession>
    <name>B8LUA1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Choline dehydrogenase, putative</fullName>
            <ecNumber evidence="6">1.1.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_060650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.1" evidence="6"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002339960.1">
        <property type="nucleotide sequence ID" value="XM_002339919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUA1"/>
    <dbReference type="STRING" id="441959.B8LUA1"/>
    <dbReference type="GeneID" id="8108546"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_060650"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_3_1"/>
    <dbReference type="InParanoid" id="B8LUA1"/>
    <dbReference type="OMA" id="HIGVSYL"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="PhylomeDB" id="B8LUA1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008812">
        <property type="term" value="F:choline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF138">
        <property type="entry name" value="DEHYDROGENASE PKFF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877387" evidence="4">
        <location>
            <begin position="26"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="600"/>
            <end position="601"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED22573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="620" mass="66728" checksum="A0AE2F41A5297EC2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUW1</accession>
    <name>B8LUW1_TALSN</name>
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        <recommendedName>
            <fullName evidence="13">Pre-mRNA-processing ATP-dependent RNA helicase PRP5</fullName>
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        <alternativeName>
            <fullName evidence="12">Pre-mRNA-processing ATP-dependent RNA helicase prp5</fullName>
        </alternativeName>
    </protein>
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        <name evidence="20" type="ORF">TSTA_074330</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="EED24053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002341399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUW1"/>
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        <property type="interactions" value="1033"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LUW1"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_0_3_1"/>
    <dbReference type="InParanoid" id="B8LUW1"/>
    <dbReference type="OMA" id="QLPMKKW"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
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    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 20" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="19">
        <location>
            <begin position="542"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="573"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="778"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="252"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="942"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="15">
        <location>
            <begin position="542"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="24"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="167"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="951"/>
            <end position="974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038511"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00040918"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00041162"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51195"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED24053.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1175" mass="129533" checksum="CF92265A9715D7C7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8LW64</accession>
    <name>B8LW64_TALSN</name>
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        <submittedName>
            <fullName evidence="1">F1F0 ATP synthase assembly protein Atp10, putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">TSTA_074710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="17089at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR28106:SF1">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05176">
        <property type="entry name" value="ATP-synt_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED24092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="318" mass="36520" checksum="44BB5F0C102E3F33" modified="2009-03-03" version="1">MLAIETRFFSILRESRCLRCQTQAVWTSVRNKSTASAPKDKQENVQPIELDRPIGLPYPPLPGQNTGIDHRSLSERRDDFVDYQKHLQRRKELAAHLAKPYFREWTNLKYNEGKTFRSNPRLFKHDKALFFPNLYGITLASPSKPKDTTDIIKGKISVVNLFSSLWAEQQVATFTKLENNPQLHEMLAASPSTTQLVDINLEENRLKAWLVRVFMGNLRRKLPREQHERYFLVQKGMTDAIKQAIGMLNSKVGYVYLVDDYGHIRWAGSGSADQSEKDYLNAGLLRLVEEKKKRLDDISGASATSSLKRRIVTTPKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8LW98</accession>
    <name>B8LW98_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GABA permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_075040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341513.1">
        <property type="nucleotide sequence ID" value="XM_002341472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LW98"/>
    <dbReference type="STRING" id="441959.B8LW98"/>
    <dbReference type="GeneID" id="8106180"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_075040"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8LW98"/>
    <dbReference type="OMA" id="PPSCQKF"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="PhylomeDB" id="B8LW98"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF41">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED24126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="524" mass="57060" checksum="C98D389F3A87574D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWB2</accession>
    <name>B8LWB2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_075950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341610.1">
        <property type="nucleotide sequence ID" value="XM_002341569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWB2"/>
    <dbReference type="STRING" id="441959.B8LWB2"/>
    <dbReference type="GeneID" id="8104191"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_075950"/>
    <dbReference type="eggNOG" id="KOG0502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034576_0_0_1"/>
    <dbReference type="InParanoid" id="B8LWB2"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="PhylomeDB" id="B8LWB2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052391">
        <property type="entry name" value="E3_Ligase-Neurotoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24133">
        <property type="entry name" value="ANKYRIN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24133:SF40">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="2"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="3">
        <location>
            <begin position="109"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="323"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="356"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="389"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="422"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="455"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED24223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="571" mass="64258" checksum="49D2D2F54FDFF220" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWG1</accession>
    <name>B8LWG1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor Prf, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_076400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341659.1">
        <property type="nucleotide sequence ID" value="XM_002341618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWG1"/>
    <dbReference type="STRING" id="441959.B8LWG1"/>
    <dbReference type="GeneID" id="8101069"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_076400"/>
    <dbReference type="eggNOG" id="ENOG502QVC1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011017_0_2_1"/>
    <dbReference type="InParanoid" id="B8LWG1"/>
    <dbReference type="OMA" id="ISVAHCQ"/>
    <dbReference type="OrthoDB" id="5600212at2759"/>
    <dbReference type="PhylomeDB" id="B8LWG1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
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        <property type="entry name" value="Fungal_trans"/>
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    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
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            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
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            <begin position="1"/>
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            <begin position="155"/>
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        <source>
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        <source>
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        <source>
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    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
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    <sequence length="862" mass="95174" checksum="5BE844CEFBAB9D6B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWP1</accession>
    <name>B8LWP1_TALSN</name>
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        <recommendedName>
            <fullName evidence="4">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_078000</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
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        </reaction>
    </comment>
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        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002341784.1"/>
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    <dbReference type="OrthoDB" id="8068875at2759"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:ligase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="14" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="13">
        <location>
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            <end position="3980"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="12">
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED24438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="3980" mass="444776" checksum="47A95844F5C0F798" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWW4</accession>
    <name>B8LWW4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_079520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341984.1">
        <property type="nucleotide sequence ID" value="XM_002341943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWW4"/>
    <dbReference type="STRING" id="441959.B8LWW4"/>
    <dbReference type="GeneID" id="8107671"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_079520"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_5_1"/>
    <dbReference type="InParanoid" id="B8LWW4"/>
    <dbReference type="OMA" id="ICTEIVH"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="PhylomeDB" id="B8LWW4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="16"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED24597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="343" mass="36346" checksum="B17F57E6510798E3" modified="2009-03-03" version="1">MSQIIGNRAAWVKEKGARPLEVGPGPIPNPAENEVVIQVAYTAINPVDVITQESPVIELPYPFILGEDVSGTVVALGSGVTRFKVGQRVTGHCDGLVTKKATNAAFQLYATCLELLVCHLPDSVPLVNAAVLPLAVSTAATGLFSVLKMPFPALNPQSTLHKILIWGGSSSVGSCAIQLAIAAGFNVVTTASSRNQAYVKSLGAQHVFEHDDPEVIKKITAILQPGDLVFDCIGSDDVREICTEILQQIGGGTLPTVRWFTPSETGNVKVEFVMGLVPGLVDTNIGDAVWGNYITKALELGKFQAKPDPYVIEGGLEKLQDGLDMLKRGVSAQKIVVEIARAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXK0</accession>
    <name>B8LXK0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Galactosyl transferase GMA12/MNN10 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_078580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341888.1">
        <property type="nucleotide sequence ID" value="XM_002341847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXK0"/>
    <dbReference type="STRING" id="441959.B8LXK0"/>
    <dbReference type="GeneID" id="8104429"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_078580"/>
    <dbReference type="eggNOG" id="ENOG502SHP1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039079_0_0_1"/>
    <dbReference type="InParanoid" id="B8LXK0"/>
    <dbReference type="OMA" id="INTHRVH"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="PhylomeDB" id="B8LXK0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF8">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 34 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED24501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="28259" checksum="5A184E97E62A2890" modified="2009-03-03" version="1">MVYGNNSIYEKAINTHRVHSRRFGYPHFILRKPILDGVWNKYAILLSVLLQELEKPPERRLQWLFWTDVDTVLINPNLPLETFLPPPHVLNAHLLLTKDWNGMNNGVFPIRVHPWSVELLSAAIAYPIMNTDVELFWPDQSALANILDTNDYFAKSVVYCPLRWFNAYMGLANGEGLNPKSPQHLQVHRGDLLVHFPGTPRGSLEETMGPYLAIAESHREDWELPLEQTDYVRETEVFWQEYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXN1</accession>
    <name>B8LXN1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_078870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341919.1">
        <property type="nucleotide sequence ID" value="XM_002341878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXN1"/>
    <dbReference type="GeneID" id="8108608"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_078870"/>
    <dbReference type="eggNOG" id="ENOG502RIGH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142428_0_0_1"/>
    <dbReference type="InParanoid" id="B8LXN1"/>
    <dbReference type="OrthoDB" id="4227359at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED24532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="156" mass="17065" checksum="98198C4A75575C4C" modified="2009-03-03" version="1">MQGLNTATVADISPLFGGAREDRVPRLLGLLKDPHQPVGKPGTFSHTIKILNMDKAIVHPNFAKPPDKDTSFPSPTTTQTLNNKSSSSSTIQYDHETYLELLAGQSNLAEKTASQIYEEERARELSLRAQDPAVLSGPLDLEADVYRYEVGDGSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYI7</accession>
    <name>B8LYI7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alcohol dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_067760</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340732.1">
        <property type="nucleotide sequence ID" value="XM_002340691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYI7"/>
    <dbReference type="STRING" id="441959.B8LYI7"/>
    <dbReference type="GeneID" id="8109461"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_067760"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_1_1"/>
    <dbReference type="InParanoid" id="B8LYI7"/>
    <dbReference type="OMA" id="HCIKSTN"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="PhylomeDB" id="B8LYI7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF6">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="18"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED23345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="362" mass="38265" checksum="12A56BA6E2B6CE00" modified="2009-03-03" version="1">MTESIPTTQTVAMVRELGDAVEFVTDYPVPTPGNNEVLAKVLYTGVCQSDLHTKSGTAASSQGTPITNIKLPHIGGHEGVGRIVKIGPNCGEGVKLGGLVGIRFLSRVCRRCEFCLAGAEQYCAKSTNHLHHEDGSFQEYIALDADNLTILPDDVDPKLIGPVLCAGVTAYKAVLNANIKVGDWVVVVGAGGGLGHLAVQYARASGASVIAVDTGNDKREYLQSVGAKEFVDFTLVPDTIEEVRRITNGGAHAVIIAAGNAKAFAHAAEMLRIGGTLSCIGIPPGRPFIETPVASIVIKGLKITGNLIGSLKECMEAVELTRKGVVIPKVQVRPFWQLPQVYEQLEKGDVPGRIVLQVAETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZC0</accession>
    <name>B8LZC0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome oxidase c assembly-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_089090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478636.1">
        <property type="nucleotide sequence ID" value="XM_002478591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZC0"/>
    <dbReference type="STRING" id="441959.B8LZC0"/>
    <dbReference type="GeneID" id="8104876"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_089090"/>
    <dbReference type="eggNOG" id="ENOG502S3II">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052684_1_0_1"/>
    <dbReference type="InParanoid" id="B8LZC0"/>
    <dbReference type="OMA" id="ANKAHKG"/>
    <dbReference type="OrthoDB" id="4205486at2759"/>
    <dbReference type="PhylomeDB" id="B8LZC0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029208">
        <property type="entry name" value="COX14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14880">
        <property type="entry name" value="COX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED21673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="31872" checksum="C32532381302DE5A" modified="2009-03-03" version="1">MSRSAADATRFTATGPYVSSKAPYQLPESLKSNKQSTTSPTSPSSVSYTSPNNQNASSSPSGETPREKVERLRAQARAARLAQNGNAFDRIIEKGRRVANSAHKVMIYTLITASGVCGALTLYSVVSLTMWNRRQRELWLDRQLQDLQAAREAYVKGTATPEQLEILRNEKIGEIEKQKRKEADEQKLWNRAKRFLFDGLKKEDVSDASVSTASGAGTTAAVSELINNKTASEQQTTSFGILEAVNAKKAESAQKHAASTQQPGSLDVLAMNAETTAKQSVKSWTSWIWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZU2</accession>
    <name>B8LZU2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nonribosomal peptide synthase, putative</fullName>
            <ecNumber evidence="6">5.1.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_081070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.1.13" evidence="6"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477837.1">
        <property type="nucleotide sequence ID" value="XM_002477792.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LZU2"/>
    <dbReference type="GeneID" id="8101412"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_081070"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_60_4_1"/>
    <dbReference type="InParanoid" id="B8LZU2"/>
    <dbReference type="OMA" id="PSNIAYV"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="PhylomeDB" id="B8LZU2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047689">
        <property type="term" value="F:aspartate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000002">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF15">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE EASA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="769"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="2290"/>
            <end position="2366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED20874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="2803" mass="311595" checksum="F49319968BC6A2CB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8M032</accession>
    <name>B8M032_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_081970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477927.1">
        <property type="nucleotide sequence ID" value="XM_002477882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M032"/>
    <dbReference type="STRING" id="441959.B8M032"/>
    <dbReference type="GeneID" id="8104835"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_081970"/>
    <dbReference type="HOGENOM" id="CLU_000680_3_3_1"/>
    <dbReference type="InParanoid" id="B8M032"/>
    <dbReference type="OMA" id="FNWGATE"/>
    <dbReference type="OrthoDB" id="4842715at2759"/>
    <dbReference type="PhylomeDB" id="B8M032"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED20964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="153" mass="16859" checksum="2747DD8BE4B32937" modified="2009-03-03" version="1">MTTSLLTLDVKGAFDSVLPGRLIRRLREQGWPTNLVLWIASFATGRSVQIRLDGEIGPSIDITCGNLRNRFGYVDDAANLVISTSLTTNCKALSDSLQEAFNWGATEGITFAPDKYELLHFSQYKADQDPTCTPSVKAGSITILENTKQLYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8M053</accession>
    <name>B8M053_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_083820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478113.1">
        <property type="nucleotide sequence ID" value="XM_002478068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M053"/>
    <dbReference type="STRING" id="441959.B8M053"/>
    <dbReference type="GeneID" id="8101475"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_083820"/>
    <dbReference type="eggNOG" id="ENOG502SJHR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031811_5_1_1"/>
    <dbReference type="InParanoid" id="B8M053"/>
    <dbReference type="OMA" id="AGCHDTG"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="PhylomeDB" id="B8M053"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057683">
        <property type="entry name" value="DUF7923"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057654">
        <property type="entry name" value="Znf-CCCH_tandem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25542">
        <property type="entry name" value="zf-CCCH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25543">
        <property type="entry name" value="zf-CCCH_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="447"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="28"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED21150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="503" mass="56425" checksum="BAB63D47F4C9E67A" modified="2009-03-03" version="1">MLNDIDLEKLSKDLTTITQTSKAYQNDLQNVLESFKDLLERYNSLKSDYEEEKEGRERYKRQAKARDRNPFVLVLIDGDGYMFKEHLIKAGTEGGVKAARLLSDSIKALLPPDLPDNCRIMVRIYANILGLSHTLARAQLVGQEARSYSGFTSSFTRAQDLFDFVDAGTQKEGADYKIREMFRLFADNYQCKHIFFGGCHDVGYLSMLTPYRGETNRITLLRAANMSPEYESLDLFIKELPSVFMSTVIGGSSAPPPTAPDKPVCKHFLKGICKFGAACTKSHVADGPKNKFNDDRSRPLSKESSGYFSRKQSYSKLLPKASGNTTSRIPVDKDGGRIDVYTPLPPDDLIHEQESLSPRPCNKHHLLGECNDVDCKFDHGYVEPELVDVMRWQAKRRQCLRGRGCRVLKCPYGHHCQIDGCAGEKPCKMGHRFHNFSPHVARWVEADDLRDSEEVQPSIEGDRDDQADARSSRSLSVATTSHTGTLSKVLIGEESPSISPVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0C0</accession>
    <name>B8M0C0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_084480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478180.1">
        <property type="nucleotide sequence ID" value="XM_002478135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0C0"/>
    <dbReference type="GeneID" id="8102730"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_084480"/>
    <dbReference type="HOGENOM" id="CLU_1225491_0_0_1"/>
    <dbReference type="InParanoid" id="B8M0C0"/>
    <dbReference type="OrthoDB" id="5552418at2759"/>
    <dbReference type="PhylomeDB" id="B8M0C0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED21217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="226" mass="25955" checksum="F10CB5182EC4752B" modified="2009-03-03" version="1">MDYARYPFEYFLNPMAAGGFESSFAQSNSTWLPHSSTQVHDQDPRPASPIQFAIEPWQEYYETSVGTDINEDVFDAQAIIKAFTSMVLNLVQMVQTSNLRLAVRALKQLSTILIHNANLLGLFEDHPNDPCKRQQNRDLWITFNICWLTTFQKQKESSQENQILDADEMEDMGDFLIHLCDGLEGYGLVDYEMGVWEEEILDSTMRAIPPPMPIDTNKITSHWPMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0G0</accession>
    <name>B8M0G0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_084880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478220.1">
        <property type="nucleotide sequence ID" value="XM_002478175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0G0"/>
    <dbReference type="STRING" id="441959.B8M0G0"/>
    <dbReference type="GeneID" id="8106094"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_084880"/>
    <dbReference type="HOGENOM" id="CLU_1961055_0_0_1"/>
    <dbReference type="InParanoid" id="B8M0G0"/>
    <dbReference type="OMA" id="HTIAIQK"/>
    <dbReference type="OrthoDB" id="5481415at2759"/>
    <dbReference type="PhylomeDB" id="B8M0G0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED21257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="128" mass="14241" checksum="E2BD04B962352A49" modified="2009-03-03" version="1">MAEYKAFELDIHMAVITAMKEDPHSIAIQKAIPAVNDRLRYLFTSPLLIRGLNATINDFIGSTFTCQFVPRGQIVPPPITGAAFGPTAPIQLPVMVLEKTSQALQYRMLRNTTTIPELWKEWTVGLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0H4</accession>
    <name>B8M0H4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_085020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
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        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
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        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
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        <property type="entry name" value="RVT_2"/>
    </dbReference>
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        <property type="entry name" value="SH3_retrovirus"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REVERSE TRANSCRIPTASE TY1_COPIA-TYPE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
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            <end position="803"/>
        </location>
    </feature>
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        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
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        <location>
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            <end position="312"/>
        </location>
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        </location>
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        <location>
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            <end position="1068"/>
        </location>
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        <location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
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            <end position="1151"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED21271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1697" mass="195154" checksum="D7FACC9C018E864A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0S2</accession>
    <name>B8M0S2_TALSN</name>
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        <recommendedName>
            <fullName evidence="4">DUF1479 domain protein</fullName>
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    </gene>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_086880"/>
    <dbReference type="eggNOG" id="ENOG502QUAF">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011148_0_0_1"/>
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    <dbReference type="PhylomeDB" id="B8M0S2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Gig2-like"/>
    </dbReference>
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        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF07350">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="409"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED21455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="51073" checksum="796C2B93E7576B43" modified="2009-03-03" version="1">MQTTNNRAESASSIASAFASLSNGVTELPPRFVALKRELVADKEDAVLAGWNRLLERVSLEKLQNLDTSIIPEVEFKDIAANSGNIPKDIVKRLRDCGTIVIRDLVEEAQALKWKEQIRNYVNKNPQTKGFPVNDIQVYELYWSKAQLEARAHENMLAAQIALNRVWSAKPEDAVDLEVPLTYCDRVRMRKPGDRSFNLGPHLDGGSLERWEDPEYRKCYAKILSGDWENHDPFDVTHRLKATVDMYNGPGGCSVFRSYQGWLSLSDCSPGSGTLHVMPDLVASTAYTLIRPFVKQTANGIDWELGLDTPHFHGTAMGTGQELTTEFHPHLNPHGFVSIPRVRPGDAVFWHCDVAHMVEAEHGGIADSSVLYIPSVPLCEVNIAYVKRQRENFIQGVAPPDFPGGVGESQHRERGQDEDVKSIAGRRAMGFQMFEVHDRLTTGQRVAAETANAILGFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0S4</accession>
    <name>B8M0S4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_086900</name>
    </gene>
    <organism evidence="9 10">
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002478375.1"/>
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    <dbReference type="STRING" id="441959.B8M0S4"/>
    <dbReference type="GeneID" id="8110096"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_086900"/>
    <dbReference type="eggNOG" id="KOG1369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014393_5_0_1"/>
    <dbReference type="InParanoid" id="B8M0S4"/>
    <dbReference type="OMA" id="HWDKGWD"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="PhylomeDB" id="B8M0S4"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF30">
        <property type="entry name" value="GLUCOKINASE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="7">
        <location>
            <begin position="17"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="8">
        <location>
            <begin position="228"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED21457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="548" mass="60096" checksum="F675F4BE4D101A16" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8M154</accession>
    <name>B8M154_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Longevity assurance factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_082290</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477959.1">
        <property type="nucleotide sequence ID" value="XM_002477914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M154"/>
    <dbReference type="FunCoup" id="B8M154">
        <property type="interactions" value="592"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M154"/>
    <dbReference type="GeneID" id="8107687"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_082290"/>
    <dbReference type="eggNOG" id="KOG1607">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028277_4_0_1"/>
    <dbReference type="InParanoid" id="B8M154"/>
    <dbReference type="OMA" id="THAAEFK"/>
    <dbReference type="OrthoDB" id="3053196at2759"/>
    <dbReference type="PhylomeDB" id="B8M154"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF11">
        <property type="entry name" value="CERAMIDE SYNTHASE LAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005225">
        <property type="entry name" value="LAG1_LAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="12">
        <location>
            <begin position="146"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED20996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="386" mass="45078" checksum="DA8582F09C323619" modified="2009-03-03" version="1">MLASASSFGSGSDHGGTRQRRQVDKKKPSTEIAKPPNEKSNIEKIRRRKYRPVWKRLANFGLKHRWPIPLIPLLVLILTYLLNPTESDIVHHFIFLSYKNNNQYGKGLRDIAFVLFYTIVLSFTRELIMHEFLRPLSLYYGITSKRKQDRFMEQMYTVIYFGLMGPLGLYIMRYSAPEVWYFNTSGMYASFPHLTLDASFKAYYLFQAAYWGQQALVMILRLEKPRKDFKELVIHHVVTLALIALSYRFHFTRIGIAVYVTHDISDFFLAISKSLHYTNSPLVAPAFGICIIVWVYLRHYLNLRILISLLPGGAFQTVGPYELNWEMEQYKCWISNVITFGLLACLQALNLFWLYCLGRSAYRFVVHRVARDDRSEDEDEVGYGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8M157</accession>
    <name>B8M157_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">5'-nucleotidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_082320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477962.1">
        <property type="nucleotide sequence ID" value="XM_002477917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M157"/>
    <dbReference type="STRING" id="441959.B8M157"/>
    <dbReference type="GeneID" id="8107690"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_082320"/>
    <dbReference type="eggNOG" id="KOG4419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005854_7_2_1"/>
    <dbReference type="InParanoid" id="B8M157"/>
    <dbReference type="OMA" id="ESEWIAT"/>
    <dbReference type="OrthoDB" id="10252235at2759"/>
    <dbReference type="PhylomeDB" id="B8M157"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07406">
        <property type="entry name" value="MPP_CG11883_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041821">
        <property type="entry name" value="CG11883_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF48">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="26"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="6">
        <location>
            <begin position="315"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="538"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="594"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="594"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="622"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED20999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="753" mass="83858" checksum="DD1E80CA1A7AEA3A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1N2</accession>
    <name>B8M1N2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_093650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479082.1">
        <property type="nucleotide sequence ID" value="XM_002479037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1N2"/>
    <dbReference type="STRING" id="441959.B8M1N2"/>
    <dbReference type="GeneID" id="8102609"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_093650"/>
    <dbReference type="eggNOG" id="ENOG502S96H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076687_1_1_1"/>
    <dbReference type="InParanoid" id="B8M1N2"/>
    <dbReference type="OMA" id="VNAQWLI"/>
    <dbReference type="OrthoDB" id="5854584at2759"/>
    <dbReference type="PhylomeDB" id="B8M1N2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039632">
        <property type="entry name" value="TMEM42"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31965">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31965:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED22119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="199" mass="21310" checksum="35575108C77D881D" modified="2009-03-03" version="1">MSTPSPSLRGSPLKTSSSFTITRWVTLAIASGAFAALNGLFAKLTTTESTGSAASKIAHAFNLPEGMVEIIVRAICFGLNLLSNFIMWALFTRALTAAPSTTKVSITNTSANFLVTAVLGMIVFRERVGGLWWLGAVMMGAGCILVGMRDDSTSHKEVSEGEGVVPSVDGDDEVETITLREDGFDDEIEPEPYRDEVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1S1</accession>
    <name>B8M1S1_TALSN</name>
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        <submittedName>
            <fullName evidence="2">Oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_094040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479121.1">
        <property type="nucleotide sequence ID" value="XM_002479076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1S1"/>
    <dbReference type="STRING" id="441959.B8M1S1"/>
    <dbReference type="GeneID" id="8103732"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_094040"/>
    <dbReference type="eggNOG" id="ENOG502RNJV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_705955_0_0_1"/>
    <dbReference type="InParanoid" id="B8M1S1"/>
    <dbReference type="OMA" id="GCHTLEN"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="PhylomeDB" id="B8M1S1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF1">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="1">
        <location>
            <begin position="115"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="347" mass="38809" checksum="FA45E9225BCBA30F" modified="2009-03-03" version="1">MGGFEFCGFYEEVEEIASELAKRLPRLPRFNTAEELLNTNPDVVMIHSLDPDVPRWARFAINHPAPFKGMFLEKPGAADPTDFYKLAEEIEAKRPGLAVELGYELHYSEALEFARKVIREDVLGDITTARFHGGCPSGAGMDLWQSIPEDLGGILQTEGCHTLENIIDIFGAPERVVSSIRKLPERPPHPVVGWIPDLFTGTVTTGEFGVGTLLYEDVCSGIMEYPDKTIVLDMTAWEPTEWCNEWAIDIYGTNGSLHVIPDFPVGTLYLRKARGSFAAGETKLSTEFPHGTSNIPSCYRKQFRSLFDRVRGKEPVDGCCDLRTNVKILKVVDAYYKSANSRQWVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1Z6</accession>
    <name>B8M1Z6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SacI domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_086050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478337.1">
        <property type="nucleotide sequence ID" value="XM_002478292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1Z6"/>
    <dbReference type="STRING" id="441959.B8M1Z6"/>
    <dbReference type="GeneID" id="8104570"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_086050"/>
    <dbReference type="eggNOG" id="KOG1890">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006249_1_0_1"/>
    <dbReference type="InParanoid" id="B8M1Z6"/>
    <dbReference type="OMA" id="YFWNRHL"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="PhylomeDB" id="B8M1Z6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034753">
        <property type="entry name" value="hSac2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022158">
        <property type="entry name" value="Inositol_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF7">
        <property type="entry name" value="SACI DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G15890)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12456">
        <property type="entry name" value="hSac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51791">
        <property type="entry name" value="HSAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="275"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="HSac2" evidence="3">
        <location>
            <begin position="709"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED21374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="957" mass="107017" checksum="8E5CAC1F1FD86BE3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2P8</accession>
    <name>B8M2P8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_092010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478922.1">
        <property type="nucleotide sequence ID" value="XM_002478877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2P8"/>
    <dbReference type="FunCoup" id="B8M2P8">
        <property type="interactions" value="100"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M2P8"/>
    <dbReference type="GeneID" id="8098586"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_092010"/>
    <dbReference type="eggNOG" id="KOG2431">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003818_0_0_1"/>
    <dbReference type="InParanoid" id="B8M2P8"/>
    <dbReference type="OMA" id="TFWMSET"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="PhylomeDB" id="B8M2P8"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="FunFam" id="1.50.10.10:FF:000037">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6hp_glycosidase-like_sf"/>
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    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
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        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF103">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSIDASE MNL2-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="151"/>
        </location>
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        <location>
            <position position="289"/>
        </location>
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    <feature type="active site" description="Proton donor" evidence="6">
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            <position position="406"/>
        </location>
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        <location>
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        </location>
    </feature>
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        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
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            <begin position="363"/>
            <end position="392"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED21959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="536" mass="60030" checksum="E431CA718568595E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2Q5</accession>
    <name>B8M2Q5_TALSN</name>
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        <recommendedName>
            <fullName evidence="7">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_092080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED21966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED21966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="32441" checksum="DC9776252EF4AD08" modified="2009-03-03" version="1">MPHRSSGVNFIHTSLTNARKRDRSAEKKTSVLADSEDDDGWELIWGPTDQEFYFKNHSTGKRRTASPKVALQGRRYLPEVEHPSERQKDEALVAALQAGYSKQVVSQILRYSMNLNVQILEYDQTPDDIEIIPHGRDMVPVTPLEWAMEHERLDLVNLFLDNGADANFTVSSADGPAVFKAAKRKSRKLVEILVQKTSRVSCTRALALVVEQQDITTTTILLAHDNVRCDFEESDRPLPPHHYEWSCGLSDSAHIKSLEAKDMTPPLARAARLGNVALLKLLLEHGADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3U5</accession>
    <name>B8M3U5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS monosaccharide transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_038930</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481122.1">
        <property type="nucleotide sequence ID" value="XM_002481077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3U5"/>
    <dbReference type="FunCoup" id="B8M3U5">
        <property type="interactions" value="1422"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M3U5"/>
    <dbReference type="GeneID" id="8107935"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_038930"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="InParanoid" id="B8M3U5"/>
    <dbReference type="OMA" id="INNMACP"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="PhylomeDB" id="B8M3U5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000044">
        <property type="entry name" value="Hexose transporter Hxt3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF92">
        <property type="entry name" value="LOW AFFINITY GLUCOSE TRANSPORTER MSTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="57"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED20688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="550" mass="60791" checksum="365ADC4DC1A3B3ED" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B8M468</accession>
    <name>B8M468_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_040050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481245.1">
        <property type="nucleotide sequence ID" value="XM_002481200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M468"/>
    <dbReference type="GeneID" id="8109764"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_040050"/>
    <dbReference type="HOGENOM" id="CLU_1670565_0_0_1"/>
    <dbReference type="InParanoid" id="B8M468"/>
    <dbReference type="PhylomeDB" id="B8M468"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="158" mass="16919" checksum="11CC0932BDA85B96" modified="2009-03-03" version="1">MCIVRLTAEAPLKAVENADLSQPLSQGQAELQDQASDATQTTSAPVLEDFTLRDIATLSSASGSPTVSPGQTQQNLPIIIAQHLESQGSSSPIESIESQDILEDFILATLYLSENFSNSLQNEIARVPSPLPQPVVIPDLPRFLDLLQGSPDWAASHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4B4</accession>
    <name>B8M4B4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Asp/Glu/hydantoin racemase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_024340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479543.1">
        <property type="nucleotide sequence ID" value="XM_002479498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4B4"/>
    <dbReference type="STRING" id="441959.B8M4B4"/>
    <dbReference type="GeneID" id="8109616"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_024340"/>
    <dbReference type="eggNOG" id="ENOG502SN3M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068086_1_0_1"/>
    <dbReference type="InParanoid" id="B8M4B4"/>
    <dbReference type="OMA" id="TNLHAAH"/>
    <dbReference type="OrthoDB" id="414270at2759"/>
    <dbReference type="PhylomeDB" id="B8M4B4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053714">
        <property type="entry name" value="Iso_Racemase_Enz_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026286">
        <property type="entry name" value="MaiA/AMDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40267">
        <property type="entry name" value="BLR3294 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40267:SF1">
        <property type="entry name" value="BLR3294 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17645">
        <property type="entry name" value="Amdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015736">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED19109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="27087" checksum="D7A8D121428256DF" modified="2009-03-03" version="1">MTKRIRLGILTPSSNTSLEPLTHSIISQLPNVSVHFSRFTVLKISLENDALAQFQNEKIIEAAKLLADAHVDMIGWSGTSSGWLGFEADEKLCEEITAATGIPSTTSVLALNRALKVLGATELGLVTPYKDDVQEAIIKTYATIGVDCSKEQHLGLWTNSHFADVTENTLDDMVADVAAKDVKFISTFCTNLYAAQRGVVWEEKYGVVLLDTVVTVIWEMLQRCRVDSTQIKGWGRLLIAKVTMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4D5</accession>
    <name>B8M4D5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_024540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479564.1">
        <property type="nucleotide sequence ID" value="XM_002479519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4D5"/>
    <dbReference type="GeneID" id="8097985"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_024540"/>
    <dbReference type="HOGENOM" id="CLU_1961057_0_0_1"/>
    <dbReference type="InParanoid" id="B8M4D5"/>
    <dbReference type="PhylomeDB" id="B8M4D5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="128" mass="14126" checksum="33616DE04F3ED445" modified="2009-03-03" version="1">MKSQFEVEISGTSGNFGGLQDRIMNRSEIEEKRKSQLLARDSWVAELKTKSAGGGMEEDLAVTTRVGRVVVPSTRAREALEDADSTDATTATRKTTSKAKPTAYLEGIYREAKSLKETLSKQEKIIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4H7</accession>
    <name>B8M4H7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_024940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479606.1">
        <property type="nucleotide sequence ID" value="XM_002479561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4H7"/>
    <dbReference type="STRING" id="441959.B8M4H7"/>
    <dbReference type="GeneID" id="8106711"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_024940"/>
    <dbReference type="eggNOG" id="KOG3105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_288879_0_0_1"/>
    <dbReference type="InParanoid" id="B8M4H7"/>
    <dbReference type="OrthoDB" id="4207519at2759"/>
    <dbReference type="PhylomeDB" id="B8M4H7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="49"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="582"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="443"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED19172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1063" mass="123616" checksum="1DA4D9188D7044E0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4J9</accession>
    <name>B8M4J9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Galactose-proton symport, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_025160</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479628.1">
        <property type="nucleotide sequence ID" value="XM_002479583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4J9"/>
    <dbReference type="GeneID" id="8106733"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_025160"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_43_5_1"/>
    <dbReference type="InParanoid" id="B8M4J9"/>
    <dbReference type="OMA" id="PYIASAC"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="PhylomeDB" id="B8M4J9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000100">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF4">
        <property type="entry name" value="SYMPORT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="478"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="129"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED19194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="634" mass="70130" checksum="416E1D58FB5191A0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4W0</accession>
    <name>B8M4W0_TALSN</name>
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        <recommendedName>
            <fullName evidence="8">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_026970</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479829.1">
        <property type="nucleotide sequence ID" value="XM_002479784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4W0"/>
    <dbReference type="STRING" id="441959.B8M4W0"/>
    <dbReference type="GeneID" id="8098977"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_026970"/>
    <dbReference type="eggNOG" id="KOG2246">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022549_3_1_1"/>
    <dbReference type="InParanoid" id="B8M4W0"/>
    <dbReference type="OMA" id="WYLFVDA"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="PhylomeDB" id="B8M4W0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF47">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="8">
        <location>
            <begin position="407"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED19395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="487" mass="56167" checksum="06DF41B3AE07A5AE" modified="2009-03-03" version="1">MQLPRLPQGVPRYVLNTGIAIFVLSLVLWSINALNIASIGSLRGRLTQPLHLDEHKDGEHNKGQLPSKLDATTDRRCHAVPNPPDVAVIVKTGANVLYDKVPLQLLSAWRCAEDPLIFSDLATTLGSYQVYDVLDNVTEAVKNSPDFDYYRKLQDYKKNGQDVRELRNEGEAGWKLDKYKFIPMLKKTWTMRPNHDWYVFLEGDTYAFWTNMLLWLQQFDPNGLYYLGEQTYVNNEGFAHGGSGFIISRGAMAKVLDDDPDITIRYDSIAQSEYYGDYVLMKALKEKGVELGLYKPMLQGEPPSSLRYGPGRYHEERYWCQPLISLHHVTPLDVDTVWQFEQHREDLSKPILFADMYQHFMAAHLPEGSDELEDWYNYSDDVHIRGPDEEDEDRPIPPEEMTPTQEQAYLSAEHCAAACAEYSRCMQYTYESSEQKCSYSFSYRFGEKRPPKSDGKRYKSGWIRSKIEKDIEENPCQSVVWKGFHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5E7</accession>
    <name>B8M5E7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_030220</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480187.1">
        <property type="nucleotide sequence ID" value="XM_002480142.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480188.1">
        <property type="nucleotide sequence ID" value="XM_002480143.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480189.1">
        <property type="nucleotide sequence ID" value="XM_002480144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5E7"/>
    <dbReference type="STRING" id="441959.B8M5E7"/>
    <dbReference type="GeneID" id="8101701"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_030220"/>
    <dbReference type="eggNOG" id="KOG4203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067096_2_1_1"/>
    <dbReference type="InParanoid" id="B8M5E7"/>
    <dbReference type="OMA" id="KPAHIKQ"/>
    <dbReference type="OrthoDB" id="10257085at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF4">
        <property type="entry name" value="URACIL PHOSPHORIBOSYLTRANSFERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="56"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED19753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="205" mass="22288" checksum="5DE50D1184E27B0C" modified="2009-03-03" version="1">MSSTLPANARISTNPFVESKLNHLRDRSLGSSAVRATTAEIARILAVEATQNHKPDHGKIGLIVVLRSGLGMSDAFLSQFAPDTDVVVYHIGMFREKYSLQPVEYYNKLPNNNTDVKRVYVIDPLIATGGTATAVIEALRDWGVEHITFVSMLTSQQGLEHAAKAWPEGTEFVIGAIDPRLDSNGYIEPGIGDIGDRLFGTGLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6E2</accession>
    <name>B8M6E2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_026280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479751.1">
        <property type="nucleotide sequence ID" value="XM_002479706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6E2"/>
    <dbReference type="GeneID" id="8098909"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_026280"/>
    <dbReference type="eggNOG" id="ENOG502SAQG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089389_1_0_1"/>
    <dbReference type="InParanoid" id="B8M6E2"/>
    <dbReference type="OMA" id="DRMGGLK"/>
    <dbReference type="OrthoDB" id="5388417at2759"/>
    <dbReference type="PhylomeDB" id="B8M6E2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="165" mass="18539" checksum="0BDF4E935FEBEB58" modified="2009-03-03" version="1">MHDGSLTPKTIDLLISLLVLILLAIVLAGSLLLLRQRRRKLEKQSHLPLYKSQAHQRRLTITQNSRTGSIHVYNEKQDLMQSSLSPPQSPVPEIRITFPEEQDESGKPKAGRVVVVHISDNGGVGLSPAQDELPPYQTNESGRFQSLDLERMGGLKEKEETKRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6M3</accession>
    <name>B8M6M3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin conjugating enzyme, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_027780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479919.1">
        <property type="nucleotide sequence ID" value="XM_002479874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6M3"/>
    <dbReference type="STRING" id="441959.B8M6M3"/>
    <dbReference type="GeneID" id="8109697"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_027780"/>
    <dbReference type="eggNOG" id="KOG0897">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003143_1_0_1"/>
    <dbReference type="InParanoid" id="B8M6M3"/>
    <dbReference type="OMA" id="LVCHCKT"/>
    <dbReference type="OrthoDB" id="109543at2759"/>
    <dbReference type="PhylomeDB" id="B8M6M3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23802">
        <property type="entry name" value="UBCc_UBE2Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000107">
        <property type="entry name" value="Ubiquitin conjugating enzyme, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051838">
        <property type="entry name" value="ARTD_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21328">
        <property type="entry name" value="POLY ADP-RIBOSE POLYMERASE FAMILY, MEMBER PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="1003"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="873"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED19485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1185" mass="131731" checksum="08AC9B5B23BCCBDF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6Z7</accession>
    <name>B8M6Z7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_034550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480651.1">
        <property type="nucleotide sequence ID" value="XM_002480606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6Z7"/>
    <dbReference type="STRING" id="441959.B8M6Z7"/>
    <dbReference type="GeneID" id="8104297"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_034550"/>
    <dbReference type="eggNOG" id="ENOG502QRRW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044368_0_0_1"/>
    <dbReference type="InParanoid" id="B8M6Z7"/>
    <dbReference type="OMA" id="YTMYLFD"/>
    <dbReference type="OrthoDB" id="4222485at2759"/>
    <dbReference type="PhylomeDB" id="B8M6Z7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="221"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED20217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="399" mass="44714" checksum="3F00642BC1A0DEF0" modified="2009-03-03" version="1">MTMEGKRYATSRRKACQHCSSAKAKCDLRDGGCSRVWARVVLLPTIWMGAVEQSGGSVAQGSIANVNGSPTNTSLTASSEGHTPNASLLNIRRHVETPEFTELDLVCPINVEDISNRWINSYVPLPGQKRKDYPASVTAFMYRILNSYVAVAVHGRGPPPFVHSSQVLPTSTKLPLSTCLSLVRICEKPRPGSEIVAADMLRREMNNIYEQRSEYDDMTLLAAFQAYMIYCMALFFTLNQTSDPFLRQAVMNLQELACATCRQGLVCTAEQQHTRPKWEAWIVAESKRRTLYAMYLLDGLLSTQDGLPTFLGTELYGLPAPSAGVLWKASTRQEWERGYNIHLADWVEASLYIHELWPIPPDMDDDGVVERRSRVDQWLENVDEYGTMMYAVTNCTHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8M742</accession>
    <name>B8M742_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutaredoxin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_034930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family. Monothiol subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480696.1">
        <property type="nucleotide sequence ID" value="XM_002480651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M742"/>
    <dbReference type="STRING" id="441959.B8M742"/>
    <dbReference type="GeneID" id="8104335"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_034930"/>
    <dbReference type="eggNOG" id="KOG1752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026126_0_0_1"/>
    <dbReference type="InParanoid" id="B8M742"/>
    <dbReference type="OMA" id="GKWIQEV"/>
    <dbReference type="OrthoDB" id="423313at2759"/>
    <dbReference type="PhylomeDB" id="B8M742"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005796">
        <property type="term" value="C:Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000093">
        <property type="entry name" value="Glutaredoxin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF5">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="4">
        <location>
            <begin position="183"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED20262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="290" mass="32267" checksum="533C0060C94ACF8B" modified="2009-03-03" version="1">MRSQRRLRLYVVVVVVFLVAFTYFTTDTGGGIQNHRFYKKTVTAMNNAHVATTKKNSEGKDRSHIQRLDLDNNNNNNNGARKTPSSPSALNDKQQEKSIGSSHNKIDTSDEISVAGRTKMSVPKPKEDQVPLSNKKTDSVDTPSVKSEAETHVAPKEHETSKEDEEEKEASAELDFILKRSPIIVFSKSYCPYSRKAKSILSQYRIVPAPYVVELNEHPLGANLQKLLGKVTGRRTVPNVLINGISIGGGDDVEALDKDDKLISKIKSVGGKSIMEIERMRVMEGHEHEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8M759</accession>
    <name>B8M759_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor OefC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_035080</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480713.1">
        <property type="nucleotide sequence ID" value="XM_002480668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M759"/>
    <dbReference type="FunCoup" id="B8M759">
        <property type="interactions" value="236"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M759"/>
    <dbReference type="GeneID" id="8104350"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_035080"/>
    <dbReference type="eggNOG" id="ENOG502QU5N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021380_0_1_1"/>
    <dbReference type="InParanoid" id="B8M759"/>
    <dbReference type="OMA" id="DMNMDFL"/>
    <dbReference type="OrthoDB" id="5333823at2759"/>
    <dbReference type="PhylomeDB" id="B8M759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="197"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="153"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED20279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="642" mass="72731" checksum="B5EDAEF0077F9638" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8M775</accession>
    <name>B8M775_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_035230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </location>
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            <dbReference type="PROSITE" id="PS50102"/>
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</entry>
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    <accession>B8M7U2</accession>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="148" mass="15921" checksum="CFC7196333C6F457" modified="2009-03-03" version="1">MRTGSSSETGTQNDQPQVLVLLASHPVNAVSGFGCTCREDPRATISCRRPFYVPPEGFESTVAGSILRYRTPPYPIAAFSLAPINLAASYQILYRTTNSFGDAVATVSTILVPHNADFTKLLSYQVAQDAANPNCLPSYAFQLEAATD</sequence>
</entry>
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    <accession>B8M824</accession>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 31 family.</text>
    </comment>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_032420"/>
    <dbReference type="eggNOG" id="KOG4086">
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Mediator of RNA polymerase II, submodule Med31 (Soh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Med31_sf"/>
    </dbReference>
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        <property type="entry name" value="Mediator_Med31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13186">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05669">
        <property type="entry name" value="Med31"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="105"/>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00019660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED19986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="115" mass="12775" checksum="6B68C8FC417628E2" modified="2009-03-03" version="1">MDNQPPPPSLTNPRFTLELDDEASSSASGKEARAFQAYLAYLYSYWKTPEYAQFLTHPGATLRALRLLQEDSFRRDIIRPQVIESLLAGGDHVQGASTAAENEGSVERHNEVQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9J4</accession>
    <name>B8M9J4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WW domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_117710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481988.1">
        <property type="nucleotide sequence ID" value="XM_002481943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9J4"/>
    <dbReference type="GeneID" id="8105829"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_117710"/>
    <dbReference type="eggNOG" id="ENOG502SPGU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079928_0_0_1"/>
    <dbReference type="InParanoid" id="B8M9J4"/>
    <dbReference type="OMA" id="PENAAGW"/>
    <dbReference type="OrthoDB" id="2367685at2759"/>
    <dbReference type="PhylomeDB" id="B8M9J4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED17996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="219" mass="24698" checksum="52C7E5266D986BDC" modified="2009-03-03" version="1">MEFVQNVVESFSSGGGRREEVVEERQEYYSSGPGGPGGPPPVPRPWVARWAEQERAWFYINEETGERRWEAPYGGGNGGGYYGEGQRGYEQSTYVQEDTYVREEPRKDHTFAYGAAGVAAGVLGGAVLGYEGEKIHNAWDREEDRIEERVEDFPENAAEWTGEKVGEVEYEADRIKNDVEDFPENAAEWVGDKVGRVERFGDEVDYAYDEGKAEGRDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MA83</accession>
    <name>B8MA83_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pogo transposable element, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_121550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482404.1">
        <property type="nucleotide sequence ID" value="XM_002482359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MA83"/>
    <dbReference type="STRING" id="441959.B8MA83"/>
    <dbReference type="GeneID" id="8098145"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_121550"/>
    <dbReference type="eggNOG" id="KOG3105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_4_0_1"/>
    <dbReference type="InParanoid" id="B8MA83"/>
    <dbReference type="OMA" id="ICMKIHY"/>
    <dbReference type="OrthoDB" id="4207519at2759"/>
    <dbReference type="PhylomeDB" id="B8MA83"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="60"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="342"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="422"/>
            <end position="503"/>
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        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED18412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="503" mass="58050" checksum="CD766E0C4DF2F26D" modified="2009-03-03" version="1">MPPIRTGYREKLVEQEGKILLAISDLKNGKIRSIRQAVRIYNVPYTTLHDRLNGIEYKIEKRANSHVLTQNEEESLLKWILDLDKRGLPPRPSLVQDMADLLLSQNGNKHVSERWVYRFVDRHPEVKLRFSRRYNYERAKCEDIKIIREHFNRVQEVIQEYGILSEDIYNFDETGFAMGLCASAKVITGSDRYGRPYLLQPGNREWVTAIEAVNSTGWALPSYVIFKATTYYQQGWFETLPQDWRLDISKNGWTTDEIGIRWLQKHFIPHTTSRTKGRYRMLILDGHGSHLTPQFDQICMKIHYTKARAMAYKAENVQNGFKATGLVPYNPDHVYEKLTVQLRTPTPPPSRSSNSQSSCQQTPQNPRQFNRQTATIKKRINDRTIGPFEVVDQAINRLSKAYEMSRNELLIIQKEVHDLRAANEKEKKKRKRSRAQISHEGSLTAQEAQELIGSRNEASQPIPTAPVESEPQTSQPRLRAPPKCSGCGIIGHKINRCPNRTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B8MB01</accession>
    <name>B8MB01_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_124290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482694.1">
        <property type="nucleotide sequence ID" value="XM_002482649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MB01"/>
    <dbReference type="GeneID" id="8098380"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_124290"/>
    <dbReference type="HOGENOM" id="CLU_1138647_0_0_1"/>
    <dbReference type="InParanoid" id="B8MB01"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="244" mass="27637" checksum="A6683B46A6558363" modified="2009-03-03" version="1">MSFDPTNPNPTMGDTFKPSPSTAVPLHGIAISRSRDTPVKKKNSPKRDMDDDVIMASSESSESDTLGNASNNNDTGTTRKADEVMYEDLDNGTIFSVFPLDSSEDGDDNDNDDEDSPEKGHNNNEYSSIDKSKVLKNGDNLTDWYNNIKIRTQSLRLVKRHIFYSKALEFERENTYISLGQLDSRDEDFLRIVPVFEINMIPDAANPTNVTKMRQRLRAYGSRWKGHWKVWCGPKLELSQNSMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8MB49</accession>
    <name>B8MB49_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">5-Methylcytosine G/T mismatch-specific DNA glycosylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_124690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482742.1">
        <property type="nucleotide sequence ID" value="XM_002482697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MB49"/>
    <dbReference type="STRING" id="441959.B8MB49"/>
    <dbReference type="GeneID" id="8100248"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_124690"/>
    <dbReference type="eggNOG" id="ENOG502S3KS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008691_0_0_1"/>
    <dbReference type="InParanoid" id="B8MB49"/>
    <dbReference type="OMA" id="KNPHTHD"/>
    <dbReference type="OrthoDB" id="5373744at2759"/>
    <dbReference type="PhylomeDB" id="B8MB49"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045138">
        <property type="entry name" value="MeCP2/MBD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074:SF5">
        <property type="entry name" value="5-METHYLCYTOSINE G_T MISMATCH-SPECIFIC DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074">
        <property type="entry name" value="METHYL-CPG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="185"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="390"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="857"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
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        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="391"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="402"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="857"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="880"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="897"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED18750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="915" mass="101014" checksum="034C137608A8CF44" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBF1</accession>
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        <dbReference type="NCBI Taxonomy" id="441959"/>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="441959.B8MBF1"/>
    <dbReference type="GeneID" id="8099633"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_116060"/>
    <dbReference type="eggNOG" id="KOG0293">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_25_1"/>
    <dbReference type="InParanoid" id="B8MBF1"/>
    <dbReference type="OMA" id="GHISGCV"/>
    <dbReference type="OrthoDB" id="972532at2759"/>
    <dbReference type="PhylomeDB" id="B8MBF1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
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        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23627">
        <property type="entry name" value="LisH_WDR26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
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        <location>
            <begin position="298"/>
            <end position="369"/>
        </location>
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        <location>
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            <end position="515"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="568"/>
            <end position="594"/>
        </location>
    </feature>
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        <location>
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            <end position="66"/>
        </location>
    </feature>
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        <location>
            <begin position="80"/>
            <end position="248"/>
        </location>
    </feature>
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        <location>
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            <end position="112"/>
        </location>
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            <end position="127"/>
        </location>
    </feature>
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            <end position="150"/>
        </location>
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        <location>
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            <end position="171"/>
        </location>
    </feature>
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            <end position="201"/>
        </location>
    </feature>
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            <begin position="219"/>
            <end position="248"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED17815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="804" mass="88595" checksum="6C1A84685A5F2072" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBM3</accession>
    <name>B8MBM3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conidial pigment biosynthesis scytalone dehydratase Arp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_116760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the scytalone dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481879.1">
        <property type="nucleotide sequence ID" value="XM_002481834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBM3"/>
    <dbReference type="STRING" id="441959.B8MBM3"/>
    <dbReference type="GeneID" id="8102068"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_116760"/>
    <dbReference type="eggNOG" id="ENOG502SNND">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101889_1_0_1"/>
    <dbReference type="InParanoid" id="B8MBM3"/>
    <dbReference type="OMA" id="TVRWNEY"/>
    <dbReference type="OrthoDB" id="5281072at2759"/>
    <dbReference type="PhylomeDB" id="B8MBM3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000030">
        <property type="entry name" value="Conidial pigment biosynthesis scytalone dehydratase Arp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049884">
        <property type="entry name" value="Scytalone_dh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02982">
        <property type="entry name" value="Scytalone_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scytalone dehydratase-like" evidence="3">
        <location>
            <begin position="82"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED17887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="238" mass="27277" checksum="FB6D0C9E712EDAD8" modified="2009-03-03" version="1">MKAQISSGVSSSVFSPTFDLNVYSKFVTVSGSIDLCRRRYLVSTFVNISKRKYLQGFSMAPSLTKDVEPSKFVSSGKPNLDISFQDFLELSKVVFDWADSYDSKDWDRLRGIIAPTLTVDYTQIGLARWDSITANEYMKMITDPSFLGDPTVKTQHLLGQTWWEKISDTEVVGHHQLRAAHQVYTDIDLKTVKVKGHGHATNEHYYRKVDGVWKFAGLKPTVRWNEYQFEDVFKACRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBS8</accession>
    <name>B8MBS8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutathione synthetase</fullName>
            <shortName evidence="9">GSH-S</shortName>
            <ecNumber evidence="9">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_119710</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9 11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="9"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482203.1">
        <property type="nucleotide sequence ID" value="XM_002482158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBS8"/>
    <dbReference type="FunCoup" id="B8MBS8">
        <property type="interactions" value="914"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MBS8"/>
    <dbReference type="GeneID" id="8105246"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119710"/>
    <dbReference type="eggNOG" id="KOG0021">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025152_2_1_1"/>
    <dbReference type="InParanoid" id="B8MBS8"/>
    <dbReference type="OMA" id="NGLVMYP"/>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="PhylomeDB" id="B8MBS8"/>
    <dbReference type="UniPathway" id="UPA00142">
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</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCB4</accession>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
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        <reaction evidence="6">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
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        </reaction>
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        <text evidence="5">Aromatic compound metabolism; naphthalene degradation.</text>
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        <text evidence="1 8">Belongs to the aldehyde dehydrogenase family.</text>
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    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
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        <property type="entry name" value="Ald_DH/histidinol_DH"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="3 8 10" id="KW-0560">Oxidoreductase</keyword>
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        <location>
            <position position="253"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED18560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="520" mass="56078" checksum="2426071FD1730879" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCT5</accession>
    <name>B8MCT5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_126950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED18987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="153" mass="17457" checksum="D879F61C4854B1AE" modified="2009-03-03" version="1">MKKAQERQATQANKKRWPINFSVGDMVYVTNEGWDTRWPGRKLGHQQEGPFLIVRQVGHAFELKLPKGMRVHPIFSPKKLRLAATKEPIEDQIADEGPELRINGQSEWEIERVGRDPDPKWYPAGYLKNAPLALKAFYDSNLKAAGPPIQLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED17499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="26406" checksum="72212C1A5FBC7CE2" modified="2009-03-03" version="1">MNTNALLLDVFHQRWLNLILDLVVTAIAVTIVALASQIHGLSSDGALGVALSNVVSFSRILMYLIQAWTQMETSMVIVPNGDWSTQGAIRFKNLTSGYGQEADIKSETKVTDFDSSAQSSPILKDITLNIEPDSKVGDHSNEEILSALAEGRIFGLIESRGGLSPTLNESSLLSGQQQLICPARALINRSRTLILGEATSNIDKETETKMMKADSRPISRMHYPCGGTSTTENSRFRFCISVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8ME56</accession>
    <name>B8ME56_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cep57 centrosome microtubule-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_015680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483717.1">
        <property type="nucleotide sequence ID" value="XM_002483672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ME56"/>
    <dbReference type="STRING" id="441959.B8ME56"/>
    <dbReference type="GeneID" id="8106308"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_015680"/>
    <dbReference type="eggNOG" id="ENOG502S3TV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004834_0_0_1"/>
    <dbReference type="InParanoid" id="B8ME56"/>
    <dbReference type="OMA" id="MKSDQIY"/>
    <dbReference type="OrthoDB" id="76453at2759"/>
    <dbReference type="PhylomeDB" id="B8ME56"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051756">
        <property type="entry name" value="Centrosomal_MT-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024957">
        <property type="entry name" value="Cep57_MT-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025925">
        <property type="entry name" value="PPC89_CLD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336:SF9">
        <property type="entry name" value="SPINDLE POLE BODY PROTEIN PPC89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336">
        <property type="entry name" value="UNCHARACTERIZED DUF1167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14197">
        <property type="entry name" value="Cep57_CLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06657">
        <property type="entry name" value="Cep57_MT_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPC89 centrosome localisation" evidence="7">
        <location>
            <begin position="420"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Cep57 centrosome microtubule-binding" evidence="6">
        <location>
            <begin position="861"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="501"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="592"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="678"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="843"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="988"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="350"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="417"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="870"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="518"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="681"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="702"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="736"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="991"/>
            <end position="1001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED16483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1022" mass="114271" checksum="D82B79B41E3F9E6F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MES9</accession>
    <name>B8MES9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="4">5.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_020210</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:23285"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="4"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484196.1">
        <property type="nucleotide sequence ID" value="XM_002484151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MES9"/>
    <dbReference type="FunCoup" id="B8MES9">
        <property type="interactions" value="791"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MES9"/>
    <dbReference type="GeneID" id="8108832"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_020210"/>
    <dbReference type="eggNOG" id="KOG0142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8MES9"/>
    <dbReference type="OMA" id="KAPFDNG"/>
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        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
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        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
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        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
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        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="11 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="13">
        <location>
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            <end position="241"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED16962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="271" mass="30462" checksum="2B2C4195AEEC3E83" modified="2009-03-03" version="1">MSATTTVTEAVAITADNVATLFPDVDISLARSILPSSNDSSVRAGGDLDGYDEEQVRLMEEVCIVLDNDDRPIGSASKKACHLMTNISRGLLHRAFSVFLFDSQNRLLLQQRAAEKITFPDLWTNTCCSHPLGIAGETGAELSAAVEGVKRAAVRKLDQELGIKAEQVPLDKFKFLTRIHYLAPSDGKWGEHEIDYILFIQADVDINPNPNEVQDTKYVTPEDLKSMFANPALKFTPWFKLICNTMLFEWWSHFGTETFDKYLLEKEIRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MF19</accession>
    <name>B8MF19_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pogo transposable element, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_009130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="PhylomeDB" id="B8MF19"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="60"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED15788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="548" mass="62873" checksum="794B0C9485A2DE19" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFF5</accession>
    <name>B8MFF5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_017630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483923.1">
        <property type="nucleotide sequence ID" value="XM_002483878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFF5"/>
    <dbReference type="FunCoup" id="B8MFF5">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="GeneID" id="8109020"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_017630"/>
    <dbReference type="eggNOG" id="KOG2615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_54_5_1"/>
    <dbReference type="InParanoid" id="B8MFF5"/>
    <dbReference type="OMA" id="PWKELQP"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="PhylomeDB" id="B8MFF5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF8">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="12"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="258"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED16689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="534" mass="58980" checksum="844936124E603855" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFU4</accession>
    <name>B8MFU4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTB/POZ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_009330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483045.1">
        <property type="nucleotide sequence ID" value="XM_002483000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFU4"/>
    <dbReference type="STRING" id="441959.B8MFU4"/>
    <dbReference type="GeneID" id="8100794"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_009330"/>
    <dbReference type="eggNOG" id="ENOG502SQDU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1541131_0_0_1"/>
    <dbReference type="InParanoid" id="B8MFU4"/>
    <dbReference type="OMA" id="AMTHRVE"/>
    <dbReference type="OrthoDB" id="4227187at2759"/>
    <dbReference type="PhylomeDB" id="B8MFU4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="34"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="174" mass="19819" checksum="0FCBA9FF5FCF03F9" modified="2009-03-03" version="1">MPEDKVAVIGSQDAQMQTDLGASIKSYILSAQFADLTIRTVDQEFKFHRLVVCGQSEYFSRLYKGEWTETNGNEVSLHDDDPCAIQAMIHFMYGFDYDSSGSEHSRAPPMLFNVKLYQIADKYVVPHRKQKAKEKFETIVQTCWRVSIPRATDLSAQQTQGGGHNWVHLWLAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>B8MG74</accession>
    <name>B8MG74_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">cytidine deaminase</fullName>
            <ecNumber evidence="6">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">TSTA_010580</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>cytidine + H2O + H(+) = uridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 21">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 23">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="6"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483175.1">
        <property type="nucleotide sequence ID" value="XM_002483130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MG74"/>
    <dbReference type="FunCoup" id="B8MG74">
        <property type="interactions" value="102"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MG74"/>
    <dbReference type="GeneID" id="8109831"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_010580"/>
    <dbReference type="eggNOG" id="KOG0758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0833">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_552281_0_0_1"/>
    <dbReference type="InParanoid" id="B8MG74"/>
    <dbReference type="OMA" id="AHPIRSH"/>
    <dbReference type="OrthoDB" id="2139348at2759"/>
    <dbReference type="PhylomeDB" id="B8MG74"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055086">
        <property type="term" value="P:nucleobase-containing small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072527">
        <property type="term" value="P:pyrimidine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000008">
        <property type="entry name" value="Cytidine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000109">
        <property type="entry name" value="Ornithine carrier protein AmcA/Ort1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004064">
        <property type="entry name" value="PRK05578.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF31">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 22 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 23" id="KW-0813">Transport</keyword>
    <keyword evidence="13 21" id="KW-0862">Zinc</keyword>
    <feature type="repeat" description="Solcar" evidence="22">
        <location>
            <begin position="27"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="22">
        <location>
            <begin position="127"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="22">
        <location>
            <begin position="231"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="24">
        <location>
            <begin position="364"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="19">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="405"/>
            <end position="411"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EED15941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="494" mass="53484" checksum="BB6ED91EE3CF8195" modified="2009-03-03" version="1">MAAIDHAAFSDEMSVEIAAPLPQSSGQNAVKDITFGSIAGIAGKYIEYPFDTVKVRLQSQPHGVPLRYAGPLDCFRQSIQSDGFRSLYRGISAPLAGAAVENSSLFFSYRIAKNILQSTFYTSTEPLPFSGLLISGAASGAFTSVLLTPIELVKCKMQVPCRTATVKPGPLKIIATVIRHHGVFGLWRGQMGTLIRESGGSAAWFGSYEAVSAVFRKSAHLDSSSESTAPLAIWQQMLAGAAAGISYNFIFYPADTIKSRMQTEEISALSSGNRSFWTVGKTVWQHEGLKGLYRGCGITVARSAPSSAFIFSIYEGLSHSGPPLLLHDHTNGQPLSTLFILHLHYNQSLQKQQNKMAAHTLSETELQTISQKAIQAKEKAYCPYSKFRVGACIITTTGEYIFGANIENASYPVGICAERVAFGNALMQGHKSFKAIAVATDIKPGASPCGMCRQFMREFTPPSFPIYMYDKDGEYKIATIGDLLPDSFGPDDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGD5</accession>
    <name>B8MGD5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_013550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483489.1">
        <property type="nucleotide sequence ID" value="XM_002483444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGD5"/>
    <dbReference type="GeneID" id="8099154"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_013550"/>
    <dbReference type="eggNOG" id="ENOG502SPS8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053555_0_1_1"/>
    <dbReference type="InParanoid" id="B8MGD5"/>
    <dbReference type="OMA" id="CEYQYLV"/>
    <dbReference type="OrthoDB" id="3538998at2759"/>
    <dbReference type="PhylomeDB" id="B8MGD5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002875155" description="GPI anchored protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED16255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="36204" checksum="7BDFFD1072982D09" modified="2009-03-03" version="1">MVAKTGLSFIAASALFARSALAANNATTVSATGCVDTSGMNTCLNNAESKFTSCMTAAGGDDEVSIACQWTQWVDQMLCYQKSCWNKIYSCEYQYLVSSYVTQQTVSVSIPYYPAPDNAPGGCSCNLGEVFNNITANTNAAANGCSQYTGSMSTALEQCQCCGWSAAVSAFYGICPDTSPNELGLSSFDSKAANFEQITGSCAGLTSQICGQYGFESADNGTFLDPTNLPAGGTNPLSTTAGPSSLTSPPAGETITWTLAGQTFVVTAAPYNGKDVAAGATTTGTDAYATTTGTGTRSGSGSGSGSGSGSGSNGSTGAKTTATGTVLPSPIKTGAATKLQGVTEAWGVGLLSLIGVAAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGE5</accession>
    <name>B8MGE5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_013650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483499.1">
        <property type="nucleotide sequence ID" value="XM_002483454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGE5"/>
    <dbReference type="STRING" id="441959.B8MGE5"/>
    <dbReference type="GeneID" id="8099164"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_013650"/>
    <dbReference type="eggNOG" id="KOG2361">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029724_1_1_1"/>
    <dbReference type="InParanoid" id="B8MGE5"/>
    <dbReference type="OMA" id="PAKYWDI"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="PhylomeDB" id="B8MGE5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052735">
        <property type="term" value="F:tRNA (cytidine-3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF11">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="6">
        <location>
            <begin position="139"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="300"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED16265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="419" mass="48305" checksum="CAE8D78AB1105816" modified="2009-03-03" version="1">MPALPPDGDYVTISQLVEPPTIPSWRSHDPARNAKRTDPFAFGQRYLEEGDDVFSYNAWDHVETDEDYKAYAELQYAKQRENPASDWHKALYNSNPAKFWDRFYKNHNQNFFKDRKWLRQEFPVLAEVTKQGAGRKVVLEVGAGAGNTAFPLINNNENEELMLFACDYSKNAVKVMRESEHYNEKFMRAEVWDVTQEEEEIDGEIKSSLPPGVEEGSVDVVILIFIMSALAPNQWSAALRNIYRVLKPGGLVLFRDYGRGDLAQVRFRKERYLAENFYVRGDEELRKIWSTWTSEKGLTMVHSGNDSDSSDRYDKTENLEGNQTEDNPERTSDETADKQREQKLIERTDKTGESVEGAFEVLNLGKDQRLLVNRQRRLKMYRCWLQARFRKRVVDNSGESQQLAPTAESIAEGLAATTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGN3</accession>
    <name>B8MGN3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)H-dependent FMN reductase LOT6, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_018540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484018.1">
        <property type="nucleotide sequence ID" value="XM_002483973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGN3"/>
    <dbReference type="STRING" id="441959.B8MGN3"/>
    <dbReference type="GeneID" id="8100964"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_018540"/>
    <dbReference type="eggNOG" id="KOG4530">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055322_2_0_1"/>
    <dbReference type="InParanoid" id="B8MGN3"/>
    <dbReference type="OMA" id="NSITEWI"/>
    <dbReference type="OrthoDB" id="68575at2759"/>
    <dbReference type="PhylomeDB" id="B8MGN3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050712">
        <property type="entry name" value="NAD(P)H-dep_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543">
        <property type="entry name" value="CHROMATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543:SF21">
        <property type="entry name" value="NAD(P)H-DEPENDENT FMN REDUCTASE LOT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADPH-dependent FMN reductase-like" evidence="1">
        <location>
            <begin position="36"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="238" mass="26238" checksum="770745779418AA42" modified="2009-03-03" version="1">MRKAPSDCAADPAADPAFTKHGLYQPILSNKMSPLQIALILGSTRPNRISPLVGNWVKTILESSGTSSPQFSILTVDIQTFDLPAFNESVHPALINDLSKFTSQSARNWNHEIAKYDAYIIISPEYHAAIPGSLKNALDFLYHAWTGKPAMIVTYGIMGGTSASEGLRVILENGFKMKVSSFAPRLEFPGRDPTKNNSSQALIEAMQGKLSVETMKFWEGKKQEIFQGFKEVLEFVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B8MH36</accession>
    <name>B8MH36_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">tRNA methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_019120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat TRM82 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484084.1">
        <property type="nucleotide sequence ID" value="XM_002484039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MH36"/>
    <dbReference type="FunCoup" id="B8MH36">
        <property type="interactions" value="261"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MH36"/>
    <dbReference type="GeneID" id="8104608"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_019120"/>
    <dbReference type="eggNOG" id="KOG3914">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022082_0_0_1"/>
    <dbReference type="InParanoid" id="B8MH36"/>
    <dbReference type="OMA" id="SERCMPK"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="PhylomeDB" id="B8MH36"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106004">
        <property type="term" value="P:tRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03056">
        <property type="entry name" value="TRM82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028884">
        <property type="entry name" value="Trm82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288:SF0">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT WDR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288">
        <property type="entry name" value="WD40 REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="281"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="39"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED16850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="492" mass="53264" checksum="BE7E034D886752AB" modified="2009-03-03" version="1">MLSTAQYPFTCIRHIGGTIVASAGPNIYSFSASDGRKISTWPELKPNDSAKAGTNDDNTESSEGPPEKKRKLSSTGTEKDEQANGKDNKFSATWLSVPILVPSPSGRYVVAVTAEDKHVRVFELNSEGVLTESSDRPVPRRPCAVAFSSDGNTIICADKGGDVYSMPLLPGESGEFELVSRAKKPSKPAANPLVVHTKRNLDALRQQLRQKQAQDNTPANPTAKRDVLSGHVSTLTDMVYAVVPSSTSASGSHSYILTADRDEQIRVSRGPPQTHVIEAFCLGHESFISTLCIPPTLPHLLVSGGGDNSIFVWDWRNGQSLYKLSVLPEGKNQIVVRDIWAVKIAGNSSVAIFVALDGSRELLSFLLEDSGNILPQESIQASGNVLDLTYLDENNMIFVSIDSCHEPGSIKDWKKDSDESPVLVEGYTVKVKDGKLVLDSVANQAVNNINAQGTAKVLAGVDESSWPKSQKAFSERLYSLQNLRKRTTGDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHI3</accession>
    <name>B8MHI3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_010800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483198.1">
        <property type="nucleotide sequence ID" value="XM_002483153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHI3"/>
    <dbReference type="STRING" id="441959.B8MHI3"/>
    <dbReference type="GeneID" id="8109853"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_010800"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2326494_0_0_1"/>
    <dbReference type="InParanoid" id="B8MHI3"/>
    <dbReference type="OMA" id="HRISYAM"/>
    <dbReference type="OrthoDB" id="5549573at2759"/>
    <dbReference type="PhylomeDB" id="B8MHI3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED15964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="11193" checksum="9D1744E1BAC3DF3B" modified="2009-03-03" version="1" fragment="single">IIDTLYEIFNACVRTGYNPTHFQRLITVVLRKGGNRDYRIPKAYRPVALLNTLSKFLEAIIAHRISYAMESEGLLPSSHLGGRKGISTDHAIQIILDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHJ4</accession>
    <name>B8MHJ4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_010910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483209.1">
        <property type="nucleotide sequence ID" value="XM_002483164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHJ4"/>
    <dbReference type="STRING" id="441959.B8MHJ4"/>
    <dbReference type="GeneID" id="8109864"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_010910"/>
    <dbReference type="HOGENOM" id="CLU_819346_0_0_1"/>
    <dbReference type="InParanoid" id="B8MHJ4"/>
    <dbReference type="OrthoDB" id="4226558at2759"/>
    <dbReference type="PhylomeDB" id="B8MHJ4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="339" mass="38049" checksum="662BA6F7D86A76FC" modified="2009-03-03" version="1">MEEFLVNTGIPQGSPLSPILFLFFNVDLIEQILAECPDVIVLGYIDDIFIMTYGTSAAANCCTLTKVHQVAERWERTHASKFAPAKYQLTHFWRKHQMVPKPSGRLDVPLTIKGVEIKPTYSIKYLGVYVMDAQGPETTSFLSVAVSTKKTKCEEEEERGKLALSLEALQIHSVMGWRPYGESGLKRQNFYLDTHLTWEVHVQEMRKKAAKLVAGLSSIAGSTWGTPLVHLRKIYTAVLQPQIMYACSTWYIQGERGFTGAQRAAEQAIQSIQDQALHQISSAFKRTSRQALEVCLHVPPAELTLAKLAEEACLRIMTSPLRSTLYQIRGQAHRNGLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MI89</accession>
    <name>B8MI89_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_040530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484526.1">
        <property type="nucleotide sequence ID" value="XM_002484481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MI89"/>
    <dbReference type="STRING" id="441959.B8MI89"/>
    <dbReference type="GeneID" id="8110010"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_040530"/>
    <dbReference type="eggNOG" id="ENOG502S0H3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="504"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="806" mass="89254" checksum="62E3D76B9819CB87" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="78" xmlns="https://uniprot.org/uniprot">
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    </protein>
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        <dbReference type="NCBI Taxonomy" id="441959"/>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
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            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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        <property type="term" value="P:conidium formation"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HTH_APSES"/>
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    </dbReference>
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        <location>
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            <end position="211"/>
        </location>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="40"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="316"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00031907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED15593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="881" mass="97932" checksum="38A7EDEACC1529D6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIV5</accession>
    <name>B8MIV5_TALSN</name>
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        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_050560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="441959.B8MIV5"/>
    <dbReference type="GeneID" id="8109098"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_050560"/>
    <dbReference type="HOGENOM" id="CLU_013929_8_1_1"/>
    <dbReference type="InParanoid" id="B8MIV5"/>
    <dbReference type="OMA" id="KCEDPRI"/>
    <dbReference type="OrthoDB" id="4207519at2759"/>
    <dbReference type="PhylomeDB" id="B8MIV5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
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        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="60"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED15617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="220" mass="25526" checksum="06F5951BF7D4F007" modified="2009-03-03" version="1">MPPIRNKNKKDLAEQKGRILLAISDLQNGRILRVAQAARIYSIPRATLQDRLNGTQQRSQVRANSHKLTQCEEELLVKWILDLDKRGLPPRHSLVREMADYLLSQRGNQQVGENWVYNLVKRRPEIESKFSRKYNYERAKCEDPKIIQEYFDRVREVISDYGILPEDIYNFDETGFAMGLCATAKPGNREWVTAIEAVNSIGWALPSYIIFKAKKYTRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIV8</accession>
    <name>B8MIV8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_050590</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485573.1">
        <property type="nucleotide sequence ID" value="XM_002485528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIV8"/>
    <dbReference type="STRING" id="441959.B8MIV8"/>
    <dbReference type="GeneID" id="8109101"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_050590"/>
    <dbReference type="eggNOG" id="ENOG502SH77">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_853052_0_0_1"/>
    <dbReference type="InParanoid" id="B8MIV8"/>
    <dbReference type="OrthoDB" id="5342292at2759"/>
    <dbReference type="PhylomeDB" id="B8MIV8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF124">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="191"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED15620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="326" mass="36488" checksum="3974D3529B01934E" modified="2009-03-03" version="1">MLQWFTQLRYPNIVSKECFSAEDSFYALCEDLPLILEHLIVYRAYPTEAQLALIVKHNPKCPWRWQSLSSPALLNQGHKSIEKMDGAGGIDSEVVNHILFKGFWIAVLWRNSTNQTHGPGTKLNSERPTYKTYLSGGNLSSMTEASPEKPAILIGLDETVGMFVGVKIDKYDLIGNTSLYKGEDREEALVLKEYSKTLLAASTIYIMCLACAKIALLLFYYSLLHVIQFWKYFMHVVIGIIAVYTIAIFFSLIFACHSIGKSWDPTPQTSHMSYCVDRLGLYLANAILNTVSDIILTLIPVPIVWSLHVPVGQKLGIAAIFAIGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJ10</accession>
    <name>B8MJ10_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_051100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485625.1">
        <property type="nucleotide sequence ID" value="XM_002485580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJ10"/>
    <dbReference type="STRING" id="441959.B8MJ10"/>
    <dbReference type="GeneID" id="8098182"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_051100"/>
    <dbReference type="eggNOG" id="KOG0683">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017290_6_1_1"/>
    <dbReference type="InParanoid" id="B8MJ10"/>
    <dbReference type="OMA" id="QRCEDPD"/>
    <dbReference type="OrthoDB" id="3364440at2759"/>
    <dbReference type="PhylomeDB" id="B8MJ10"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785">
        <property type="entry name" value="GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785:SF2">
        <property type="entry name" value="TYPE-1 GLUTAMINE SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS catalytic" evidence="5">
        <location>
            <begin position="118"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED15672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="477" mass="53240" checksum="14241C9BC0B1179C" modified="2009-03-03" version="1">MASQDAHIALWQRFLNTNVNTEFVFVQFMGYNANILMRAIPVARFAELIKKNQTLSLTRAIFYLLPHDYLAEGGDPLGIFYLKPDLSTLHPHPENSGRTYVIADAVQEDGVTAIPECPRSRLKHLNEFMVQETGCYPVVGFEVEVVFMKRVKDADGQVTAYQLVNKDHSFQSLTTDDEQYLTMMEIIAKTLLAAEIEIEQFHAEAAPGQWEFVLPPSRPVEAVDTLIRARGIISRVAEMHQLRATLFPRPSESHAGNGAHVHISCNANGSSPVPLTNMGHQTKESFFAGILEHLPAILAFNLPQQESYARVQSGIWSGGEYAAWGWENKEVPLRRIESNHFELKLMDGFANPYLALCAILAAGIDGMKRGINLTAGPCPKGANLLSPEEREQLGIRTLLPKSLTESLDSLVSDTTICESVGQAIIQPYVAIKRGEIEQVKTWTGVERRNYLISRYYRYQLGQNLEIPQSGNTDKVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJ84</accession>
    <name>B8MJ84_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_041510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484626.1">
        <property type="nucleotide sequence ID" value="XM_002484581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJ84"/>
    <dbReference type="STRING" id="441959.B8MJ84"/>
    <dbReference type="GeneID" id="8109736"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_041510"/>
    <dbReference type="eggNOG" id="ENOG502SJYB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1444231_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJ84"/>
    <dbReference type="OrthoDB" id="4503105at2759"/>
    <dbReference type="PhylomeDB" id="B8MJ84"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED14673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="204" mass="23342" checksum="191F040C16927634" modified="2009-03-03" version="1">MLATLTFPFKNSLKKYMQISEPSKRTVIAVIEGDNEEARCVAGGIPLRKLDHLTDRTLVPGNPDHYYGACPEQLNRRIRNERDNQIIPTTEDKIPIAPNSFLAVKGPDGLASVVKRQACYDNAFGVRGMHSLQEYGKDEPEFDNHAYTISSIYHDGTSNIFTIHPSKPSDRLEYHMTRLRSFVITDTFRQGVIWYRNARDWVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MK52</accession>
    <name>B8MK52_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH:ubiquinone reductase (non-electrogenic)</fullName>
            <ecNumber evidence="2">1.6.5.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_043440</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a quinone + NADH + H(+) = a quinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:46160"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a ubiquinone + NADH + H(+) = a ubiquinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:23152"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.9" evidence="2"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484822.1">
        <property type="nucleotide sequence ID" value="XM_002484777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MK52"/>
    <dbReference type="FunCoup" id="B8MK52">
        <property type="interactions" value="330"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MK52"/>
    <dbReference type="GeneID" id="8097852"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_043440"/>
    <dbReference type="eggNOG" id="KOG2495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021377_1_0_1"/>
    <dbReference type="InParanoid" id="B8MK52"/>
    <dbReference type="OMA" id="QIPAQKD"/>
    <dbReference type="OrthoDB" id="3244603at2759"/>
    <dbReference type="PhylomeDB" id="B8MK52"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120555">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) (non-electrogenic) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF47">
        <property type="entry name" value="EXTERNAL NADH-UBIQUINONE OXIDOREDUCTASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="11">
        <location>
            <begin position="107"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="External alternative NADH-ubiquinone oxidoreductase-like C-terminal" evidence="12">
        <location>
            <begin position="504"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED14869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="572" mass="64653" checksum="7EC09F66ED0C16B4" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MK59</accession>
    <name>B8MK59_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamine amidotransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_043480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484829.1">
        <property type="nucleotide sequence ID" value="XM_002484784.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484830.1">
        <property type="nucleotide sequence ID" value="XM_002484785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MK59"/>
    <dbReference type="FunCoup" id="B8MK59">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MK59"/>
    <dbReference type="GeneID" id="8097856"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_043480"/>
    <dbReference type="eggNOG" id="KOG1268">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042555_4_0_1"/>
    <dbReference type="InParanoid" id="B8MK59"/>
    <dbReference type="OMA" id="SVHPAWN"/>
    <dbReference type="OrthoDB" id="14446at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061672">
        <property type="term" value="C:glutathione hydrolase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01908">
        <property type="entry name" value="YafJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000045">
        <property type="entry name" value="Glutamine amidotransferase DUG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052373">
        <property type="entry name" value="Gamma-glu_amide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187:SF1">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED14876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="371" mass="41214" checksum="B981D74FE7DF430B" modified="2009-03-03" version="1">MCRFLVYKGRSEILLSKLVTEPSHSILTQSYDSRLRLDTRRPVNGDGFGVGFYPDPKLGPEPCIFTSTLPAWNCENLERLASKTCSNLIFAHVRASTEGALADNNCHPFQHNSLMWMHNGNLGGWNYIKRPLSQSLNDKWYLGVKGGTDSEWAFALFLDLMEKEGADPSSDPGPDGFGQAFLRQVMIKTIAKINEFIRLIPEKHKVTDLETRSLLNFAVTDGHTVVCTRYVSSKTDEPASLYFSSGTKWKEGKKEGHFKMERHDKGADIVLVASEPITFERHNWVTVPTNSILTIHKQTVLLHPIIDEFYNDDPNHDRSSVYALSKGFAPPAVVTPTKSTAAAAKASMAQTNGSTKLDALAPKVTQLELAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8MK71</accession>
    <name>B8MK71_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nuclear transport factor 2 domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_046770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485179.1">
        <property type="nucleotide sequence ID" value="XM_002485134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MK71"/>
    <dbReference type="STRING" id="441959.B8MK71"/>
    <dbReference type="GeneID" id="8108041"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_046770"/>
    <dbReference type="eggNOG" id="ENOG502ST13">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112120_1_0_1"/>
    <dbReference type="InParanoid" id="B8MK71"/>
    <dbReference type="OMA" id="VPNWDAM"/>
    <dbReference type="OrthoDB" id="25408at2759"/>
    <dbReference type="PhylomeDB" id="B8MK71"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTF2" evidence="1">
        <location>
            <begin position="16"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="155" mass="17080" checksum="BD9DC9F4D5FF6867" modified="2009-03-03" version="1">MATPKEDLLTKVSTEGATDFVQLYHSALSSNKRSIASFYSSAPTNILFNGNVIADGAAVEDIFTNQLPTTRHDIQSVDCQIINKTYPTTTPGKTARENAKNISMLVIVSGSVQYGGKDSPQHGFSETFVLIPNVENKEKNRKDWLIQSQNFRLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLP0</accession>
    <name>B8MLP0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">2-ketogluconate transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_101430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486141.1">
        <property type="nucleotide sequence ID" value="XM_002486096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLP0"/>
    <dbReference type="GeneID" id="8101831"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_101430"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_2_1"/>
    <dbReference type="InParanoid" id="B8MLP0"/>
    <dbReference type="OMA" id="FMADAIT"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="PhylomeDB" id="B8MLP0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033229">
        <property type="term" value="F:cysteine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="52"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED13903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="316" mass="36083" checksum="6D61C8BDCFAACCA4" modified="2009-03-03" version="1">MAKTDDINLEVPQTAEVEVVKDHMNYDLVDKEVVEVDKPTSRRLRRLIDKRVMVVMTITYLIQTLDKGTMSYASIMGIVSDAHLVGQQYSWMTTILYLIILCVEYPENYIIQRVPIAKWLFLNVILWGIVLALQAATKNFAGLITLRAFLGVFEAATQPTFTLLSSIWYTREEQAGAVTFWFMMNGLNQILGGLLAFCFSFVPSTGPVKSWQALFMSYGILTVLWGLFIAWWMPDSPMKVHCFSEEDKKLMVERVRKNRTGLQNRQFRKEQLCDALTDPQFYAIILIQLTLTIPSGGLGAFNNIIVKSFGFTTWQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MM54</accession>
    <name>B8MM54_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_098230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485804.1">
        <property type="nucleotide sequence ID" value="XM_002485759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MM54"/>
    <dbReference type="STRING" id="441959.B8MM54"/>
    <dbReference type="GeneID" id="8108462"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_098230"/>
    <dbReference type="eggNOG" id="KOG3332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034979_0_2_1"/>
    <dbReference type="InParanoid" id="B8MM54"/>
    <dbReference type="OMA" id="VSRYMWF"/>
    <dbReference type="OrthoDB" id="440160at2759"/>
    <dbReference type="PhylomeDB" id="B8MM54"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF11">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED13566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="309" mass="35588" checksum="4BF36D74C93E6136" modified="2009-03-03" version="1">MAKSKILAVATHLGRRAYRHKLSLISLCFVIFFIIPIFLYTLLGTILANDPRLVPHAIRNARNVLLITAHPDDESLFFSPSILHHSDMPHVNRHLLVLSSGNFNGLGEHRRTETKASCAALGIKDDNCVVLDNKDLQDNPRQWWDDSIIEKILADYIKKWNIDLIITFDHYGVSGHVNHRSVSRGVKKFCDEHDHMPPVYANRSKFLLRKYSSLFDLIPTSLPFTWRILEALVSPVPKGYETAVSITEKPVPPPEGGDKYGDKALLVTDWRQYRQGRTAFQQHASQYSWDRVLYLIVSRYMWFNDLKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8MML2</accession>
    <name>B8MML2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L21, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_100120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486004.1">
        <property type="nucleotide sequence ID" value="XM_002485959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MML2"/>
    <dbReference type="FunCoup" id="B8MML2">
        <property type="interactions" value="775"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MML2"/>
    <dbReference type="GeneID" id="8105455"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_100120"/>
    <dbReference type="eggNOG" id="KOG1732">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103610_0_0_1"/>
    <dbReference type="InParanoid" id="B8MML2"/>
    <dbReference type="OMA" id="INYGDYV"/>
    <dbReference type="OrthoDB" id="1539250at2759"/>
    <dbReference type="PhylomeDB" id="B8MML2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.70:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3260:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED13766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="160" mass="18373" checksum="0851E41B15652E62" modified="2009-03-03" version="1">MGHSHGLRAGTRYAFSRDFKKKGSIPLSTYLKEYRVGDIVDIKCNGAVQKGLPYKYYHGKTGVVYNVTRSAVGVIVYKRVGNRYLEKRLNVRIEHVSHSRSREEFINRVKENAIKKRQAKEQGIHLHLKRQAVQPRSAHVVDSSDNFPETITPIPYDTHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8MN47</accession>
    <name>B8MN47_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposable element Tc1 transposase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_107040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486734.1">
        <property type="nucleotide sequence ID" value="XM_002486689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MN47"/>
    <dbReference type="STRING" id="441959.B8MN47"/>
    <dbReference type="GeneID" id="8103604"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_107040"/>
    <dbReference type="eggNOG" id="ENOG502S95U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033666_0_1_1"/>
    <dbReference type="InParanoid" id="B8MN47"/>
    <dbReference type="OMA" id="RRCINSH"/>
    <dbReference type="OrthoDB" id="4349822at2759"/>
    <dbReference type="PhylomeDB" id="B8MN47"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="257" mass="30387" checksum="0C5EA7852122D58E" modified="2009-03-03" version="1">MDEIIAWISQSKKNRRMPYHKVIRALNLSVSPTTLAYTLRKRGYTRCKALRKPDLSPEHRRQRLIWALEHVNWTIEQWNKILWTDETWVTSECHTRIYVTRTTGEEYDDTCLRSRRQRYWGWMFWGSIHGNTKGPCLFWEKEWGTIKAETYCQRTVPIIDGYLRLLRSEGLQSMQDGAPGHSGAFTREELHSRVWDWMKSWIDERYPEDDELSYDLLRQAVRAAWDAVPDSFLAKLIDGMQARCQAVIDAEGGPIPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8MP91</accession>
    <name>B8MP91_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Maltose permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_105410</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486568.1">
        <property type="nucleotide sequence ID" value="XM_002486523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MP91"/>
    <dbReference type="GeneID" id="8098762"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_105410"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="InParanoid" id="B8MP91"/>
    <dbReference type="OMA" id="MRAYDIE"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="PhylomeDB" id="B8MP91"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF83">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="27"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED14330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="530" mass="59491" checksum="00F1EACC153B39B4" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPU2</accession>
    <name>B8MPU2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_052710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486861.1">
        <property type="nucleotide sequence ID" value="XM_002486816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPU2"/>
    <dbReference type="STRING" id="441959.B8MPU2"/>
    <dbReference type="GeneID" id="8098220"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_052710"/>
    <dbReference type="eggNOG" id="ENOG502SP01">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015771_4_1_1"/>
    <dbReference type="InParanoid" id="B8MPU2"/>
    <dbReference type="OMA" id="FLESFAW"/>
    <dbReference type="OrthoDB" id="3469466at2759"/>
    <dbReference type="PhylomeDB" id="B8MPU2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED12750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="758" mass="85126" checksum="89C4CF5258FE2D44" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRA7</accession>
    <name>B8MRA7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_055080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487113.1">
        <property type="nucleotide sequence ID" value="XM_002487068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRA7"/>
    <dbReference type="STRING" id="441959.B8MRA7"/>
    <dbReference type="GeneID" id="8100514"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_055080"/>
    <dbReference type="eggNOG" id="ENOG502SJU9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089363_0_0_1"/>
    <dbReference type="InParanoid" id="B8MRA7"/>
    <dbReference type="OMA" id="AWADPCK"/>
    <dbReference type="OrthoDB" id="9976870at2759"/>
    <dbReference type="PhylomeDB" id="B8MRA7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02208">
        <property type="entry name" value="cupin_RmlC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED13002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="25982" checksum="94D631044DAC423C" modified="2009-03-03" version="1">MFTFLRGSTPPKTFRAHDNPIYYEDGTSFVQFNEAGSKYILRNQHPPFDSTKPSIMTPPFHWHINQTEHFSIVEGECHLFKENPEKPWMTISAKDPNAPKTASIPKTVFHTIHNASTTEPMVVDVNLTPEDAESEQKFFRNFFGYLDDCRKAGVPPSMFQLFVFLNEADTPVAVPLPSKFLSKVASRVMLSSVAWYGRWILGYKTSYPEYYDDGKSSINHFGKSRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRY3</accession>
    <name>B8MRY3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Choline transport protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_059070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="protein sequence ID" value="EED13419.1"/>
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        <property type="nucleotide sequence ID" value="XM_002487485.1"/>
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    <dbReference type="STRING" id="441959.B8MRY3"/>
    <dbReference type="GeneID" id="8106591"/>
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    <dbReference type="HOGENOM" id="CLU_004495_6_1_1"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA/rel_permease1"/>
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        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
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        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_transporter"/>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
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        <location>
            <begin position="440"/>
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        </location>
    </feature>
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        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED13419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="584" mass="63621" checksum="098ECEDC52A8E539" modified="2009-03-03" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
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        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
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    </dbReference>
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            <end position="17"/>
        </location>
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            <end position="257"/>
        </location>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED12130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="257" mass="28793" checksum="26CC6D1DB769F497" modified="2009-03-03" version="1">MAMGSLLFRSLSLLVAAVAISCAFSSLGVSPFEWLRASKDNGFQISHPQIYTLSDDPLVVYVKDFISTQEAAHLVQLANGRFTPSSIWDNDGKSHIDKAYRLSMTAKLDRSDEIIKKIEERAISFPFYKLVGDFMPIVVQNYGISGQYRDHYDWFDDAQAVGGNIASTFFVYIHANCTGGGTNFARLTPPDDDSWCEFIDCDRPFDEGITFKPILGNAIYWENLQEDDAGHKMTLHAGMPVTTGNKMGMNMWTWKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8MS88</accession>
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        <name evidence="1" type="ORF">TSTA_002850</name>
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        </lineage>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="PhylomeDB" id="B8MS88"/>
    <dbReference type="Proteomes" id="UP000001745">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED12221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="280" mass="31927" checksum="3D05DB1A14867C23" modified="2009-03-03" version="1">MGLPYTPLEELDRVLKDFFKKGPAYASYKFQALFQAAMYVETVVYVDERLMRTTGSMIAKSVSWESCKLACTLVLLFASPPSAFMLKTLTWQSRNLDGFPTMAEISSTPSVDLPKRFAQAKKAAIDGKVGKVTVLGVSLIDVEIIERAEVGRNDVDFDFTSFTHSFALAIGREGFRVYQSWGEHGYRLDQFLTRGGSRIRSWEEGKAFMKAFKKLASATKWSPELNSAYKELFEVDIDSICGEWRVQPPLIPVYRPWVRVFEINDVQVNHIKKFTWKIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSF5</accession>
    <name>B8MSF5_TALSN</name>
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        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_000280</name>
    </gene>
    <organism evidence="5 6">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED11950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSF5"/>
    <dbReference type="STRING" id="441959.B8MSF5"/>
    <dbReference type="GeneID" id="8107456"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_000280"/>
    <dbReference type="eggNOG" id="KOG0502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_2_1"/>
    <dbReference type="InParanoid" id="B8MSF5"/>
    <dbReference type="OMA" id="CYRGHDK"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="PhylomeDB" id="B8MSF5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055497">
        <property type="entry name" value="DUF7069"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23239">
        <property type="entry name" value="DUF7069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="416"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7069" evidence="3">
        <location>
            <begin position="614"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="872"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="905"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="938"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="971"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1004"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1037"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1102"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1135"/>
            <end position="1167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED11950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1180" mass="132232" checksum="6DD2BA2F7C5FFAC9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSG1</accession>
    <name>B8MSG1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_000340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED11956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487610.1">
        <property type="nucleotide sequence ID" value="XM_002487565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSG1"/>
    <dbReference type="STRING" id="441959.B8MSG1"/>
    <dbReference type="GeneID" id="8108657"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_000340"/>
    <dbReference type="eggNOG" id="ENOG502SN6A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_0_0_1"/>
    <dbReference type="InParanoid" id="B8MSG1"/>
    <dbReference type="OMA" id="MELAMIN"/>
    <dbReference type="OrthoDB" id="3529975at2759"/>
    <dbReference type="PhylomeDB" id="B8MSG1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="29"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED11956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="317" mass="34700" checksum="A589EA19E3406C63" modified="2009-03-03" version="1">MRVGSSTAIPFVKEIQCWITSADAPTLIILKLIYTIYFVYDAAICIARASALLFYNRVFTRRANTAAFNAILWALHALNITWFIGIVFGTIFLCKPINKNWDPALPGTCGPTRALWIGSAVPSVSIDLIILILPLPKIWHLRETSFKRKVGLIVVFILGYCVVIVSLGRLISILISGDALNIDITYEGMPVVYWITAEAPILLLGICVPAMLPLSRHLTAHYFVPLMSKSSSVLKTFSSSGSSKIRSTNGSFSQGTSASHKLYLQAGNTGTLASSAEDIEMSSDHSMSSQREIFRTARKQEEYSAACEAGNSRPEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSQ6</accession>
    <name>B8MSQ6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF410 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_005510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GET4 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488168.1">
        <property type="nucleotide sequence ID" value="XM_002488123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSQ6"/>
    <dbReference type="FunCoup" id="B8MSQ6">
        <property type="interactions" value="380"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MSQ6"/>
    <dbReference type="GeneID" id="8105525"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_005510"/>
    <dbReference type="eggNOG" id="KOG3024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046061_0_1_1"/>
    <dbReference type="InParanoid" id="B8MSQ6"/>
    <dbReference type="OMA" id="LMDMMGM"/>
    <dbReference type="OrthoDB" id="10252405at2759"/>
    <dbReference type="PhylomeDB" id="B8MSQ6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000272">
        <property type="entry name" value="DUF410 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007317">
        <property type="entry name" value="GET4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875:SF0">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04190">
        <property type="entry name" value="GET4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED12514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="341" mass="37352" checksum="CA0833EF97737785" modified="2009-03-03" version="1">MTSKIDKTIARQQEKIAAGSYYEAHQQLRVIAARYLKQSNYDAAAEILTGGAKALLRAGSQQGASASGGDLAIMLVVEVYNKAEWEIGLDDAESRGRKKRLIELLREFPPDEPSRKRYITEIISWSSKFGPLERGDPELHHAAGSVYAEENEPYDAERHLILGTTDSAETLAKLEFEWYTADDAHTAGIYASRAVIPYLLTANLRNANKALLIFTSRLSAAYPSLASQQVSSTSADVRIYPSLPLLNFLSLLLIAVQRGSADLFRDLTRHYTPHIEEVGIWDDALATIGEMYFNIKIPRQGNPLLDMMGSMFFGGGGGGGGGNQRGQSRRVEAAPASAELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSR0</accession>
    <name>B8MSR0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_005550</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488172.1">
        <property type="nucleotide sequence ID" value="XM_002488127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSR0"/>
    <dbReference type="FunCoup" id="B8MSR0">
        <property type="interactions" value="1105"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MSR0"/>
    <dbReference type="GeneID" id="8105529"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_005550"/>
    <dbReference type="eggNOG" id="KOG1063">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006430_0_0_1"/>
    <dbReference type="InParanoid" id="B8MSR0"/>
    <dbReference type="OMA" id="ENFRHIS"/>
    <dbReference type="OrthoDB" id="27911at2759"/>
    <dbReference type="PhylomeDB" id="B8MSR0"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000400">
        <property type="entry name" value="Elongator acetyltransferase complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037289">
        <property type="entry name" value="Elp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="52"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="102"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="207"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="289"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="ETS" evidence="12">
        <location>
            <begin position="386"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="659"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED12518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="808" mass="89140" checksum="3D8D379597290F8A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8MT45</accession>
    <name>B8MT45_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_003110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487902.1">
        <property type="nucleotide sequence ID" value="XM_002487857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MT45"/>
    <dbReference type="GeneID" id="8098007"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_003110"/>
    <dbReference type="eggNOG" id="ENOG502SXRJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_156018_0_0_1"/>
    <dbReference type="InParanoid" id="B8MT45"/>
    <dbReference type="OMA" id="RVCGHNE"/>
    <dbReference type="OrthoDB" id="5394455at2759"/>
    <dbReference type="PhylomeDB" id="B8MT45"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="101" mass="11446" checksum="4FD5ED6F4EA4888D" modified="2009-03-03" version="1">MMQLAEVLSDLTSLRACGHHEALVLVNVHKATVAKTSTEEDDTKRDAEQHTDLSRAKELMELHYGVKVKHMGNAPNYEPVIDEGLRRAREDVNRVLRELDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8MT58</accession>
    <name>B8MT58_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent RNA helicase eIF4A</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Eukaryotic initiation factor 4A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Translation initiation factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">TSTA_003230</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the eIF4F complex, which composition varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487915.1">
        <property type="nucleotide sequence ID" value="XM_002487870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MT58"/>
    <dbReference type="FunCoup" id="B8MT58">
        <property type="interactions" value="1291"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MT58"/>
    <dbReference type="GeneID" id="8098019"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_003230"/>
    <dbReference type="eggNOG" id="KOG0327">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="InParanoid" id="B8MT58"/>
    <dbReference type="OMA" id="FGCQALV"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="PhylomeDB" id="B8MT58"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18046">
        <property type="entry name" value="DEADc_EIF4AII_EIF4AI_DDX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000089">
        <property type="entry name" value="Eukaryotic initiation factor 4A-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044728">
        <property type="entry name" value="EIF4A_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 22" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="55"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="236"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="17">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EED12261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="397" mass="44662" checksum="86968CF131BC746D" modified="2009-03-03" version="1">MASKGGLEEVPEGQIESNYDEVTDSFDAMNLKPELLRGVYAYGFERPSAIQQRAIMPVIKGNDVIAQAQSGTGKTATFSISALQKIDSSLKACQALILAPTRELAQQIQKVVVAIGDFMSIECHACIGGTNVREDMKALQDGPQVVVGTPGRVQDMIQRRVLRTDNIKMFVLDEADEMLSRGFTEQIYDIFQLLPQSTQVVLLSATMPQDVLEVTTKFMRDPVRILVKKDELTLEGIKQFYIAVEKEEWKLDTLSDLYETVTITQAVIFCNTRRKVDWLTDKLTARDFTVSAMHGDMEQSQRDVIMKEFRSGSSRVLIATDLLARGIDVQQVSLVINYDLPANRENYIHRIGRGGRFGRKGVAINFVTADDVRMMREIEQFYNTQIEEMPMNVADLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUP4</accession>
    <name>B8MUP4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA/RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_108930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488468.1">
        <property type="nucleotide sequence ID" value="XM_002488423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUP4"/>
    <dbReference type="STRING" id="441959.B8MUP4"/>
    <dbReference type="GeneID" id="8103149"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_108930"/>
    <dbReference type="eggNOG" id="ENOG502QQKF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010014_4_0_1"/>
    <dbReference type="InParanoid" id="B8MUP4"/>
    <dbReference type="OMA" id="VETHGFY"/>
    <dbReference type="OrthoDB" id="2017974at2759"/>
    <dbReference type="PhylomeDB" id="B8MUP4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF0">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN EST1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA-binding" evidence="1">
        <location>
            <begin position="49"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="427" mass="48483" checksum="64FF9731624772D7" modified="2009-03-03" version="1">MAFANITQLLESVPDYKETWIECLGDLARYRMAIEEVDMYNRRRYTSIARYWYAKAANLNPDVGRIQHHLAVLARPDLLKQLFYYSKALIGVQPFTKARDSILLLFRPLLDPAKAAIKYPEYYSRTLTVFVEAHGVLFTRKDAPTFLRLAEEFLSELDKHAGLVAAIFDYGHDGAEIPSMFDQASGRVESRVRDRDEGGSIQTRTLEIMEQAYESWQNPSCVQVGIEHRTAGISSSKQVVSMASHLSFATLDVILGGLKDIENTLPSVHVSLAFLWCMAMVLEAMSRIQADVPWKRLATYLNKLIKTDTDMVGIENGEFPARESGLRQLPEDFLIHGLSWSRIYYPPGFFSDMAEGDERSIEPPSVTVARTKRCLWLASKIAKFNCWLLYDVETHGFYATQFADELTALSQRYQIIGRTDSIITSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MV99</accession>
    <name>B8MV99_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_008510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962662">
        <property type="protein sequence ID" value="EED11555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488736.1">
        <property type="nucleotide sequence ID" value="XM_002488691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MV99"/>
    <dbReference type="STRING" id="441959.B8MV99"/>
    <dbReference type="GeneID" id="8103239"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_008510"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_23_5_1"/>
    <dbReference type="InParanoid" id="B8MV99"/>
    <dbReference type="OMA" id="NRHMISA"/>
    <dbReference type="OrthoDB" id="5059038at2759"/>
    <dbReference type="PhylomeDB" id="B8MV99"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="56953" checksum="F34140F2FCBEA4EC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>H9CNL3</accession>
    <name>H9CNL3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Intron-encoded GIY-YIG endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_m0020</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="6"/>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="BMC Genomics" volume="13" first="698" last="698">
            <title>Sequencing of mitochondrial genomes of nine Aspergillus and Penicillium species identifies mobile introns and accessory genes as main sources of genome size variability.</title>
            <authorList>
                <person name="Joardar V."/>
                <person name="Abrams N.F."/>
                <person name="Hostetler J."/>
                <person name="Paukstelis P.J."/>
                <person name="Pakala S."/>
                <person name="Pakala S.B."/>
                <person name="Zafar N."/>
                <person name="Abolude O.O."/>
                <person name="Payne G."/>
                <person name="Andrianopoulos A."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="23234273"/>
            <dbReference type="DOI" id="10.1186/1471-2164-13-698"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To endonucleases of group I introns of fungi and phage.</text>
    </comment>
    <dbReference type="EMBL" id="JQ354994">
        <property type="protein sequence ID" value="AFD95907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9CNL3"/>
    <dbReference type="STRING" id="441959.H9CNL3"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_m0020"/>
    <dbReference type="InParanoid" id="H9CNL3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006350">
        <property type="entry name" value="Intron_endoG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003647">
        <property type="entry name" value="Intron_nuc_1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010896">
        <property type="entry name" value="NUMOD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003611">
        <property type="entry name" value="NUMOD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01453">
        <property type="entry name" value="grpIintron_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07453">
        <property type="entry name" value="NUMOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00497">
        <property type="entry name" value="IENR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00496">
        <property type="entry name" value="IENR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64496">
        <property type="entry name" value="DNA-binding domain of intron-encoded endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="5">
        <location>
            <begin position="62"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFD95907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="279" mass="32369" checksum="EB46F00C4903E200" modified="2012-05-16" version="1">MYKNNKNKNNFYKKYYSTKTNSGNYSKVVTDFLTDKNLNAVICFEDLQLQETKNIINEYSKNKAGIYLILNKVTLDYYIGSAATSRFYSRFHKHLIGLVGSKIVKNAVRKYGINNFAFIVLELFPEEVNKENNKKLLNIEDFYIKSLLPNYNILTEAGNSFGYKHTEIDRIKMKANYSEERRNRIGLLNKGKKLSEVTVERMREKALLRSSYSYSQEGLANLKKNSKPIVLYNKDGTVYGEYSSIVEVSNSLNCSVKTISRALKSNSKILKRTWYVKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8LT02</accession>
    <name>B8LT02_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_064640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340385.1">
        <property type="nucleotide sequence ID" value="XM_002340344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LT02"/>
    <dbReference type="STRING" id="441959.B8LT02"/>
    <dbReference type="GeneID" id="8102393"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_064640"/>
    <dbReference type="eggNOG" id="ENOG502SHHA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044876_3_3_1"/>
    <dbReference type="InParanoid" id="B8LT02"/>
    <dbReference type="OMA" id="HESTNEA"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="PhylomeDB" id="B8LT02"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="7"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED22998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="306" mass="33784" checksum="6381B4F3D92FB66B" modified="2009-03-03" version="1">MAPPLRNVVLIGASGDIGRIILDSLVESGLFSITVLTLGLKNATFPPTVNVRKSDLSDSELESAFRGQDVVISVVGMSALLDQKRYIDIAVRVGVKHFLPSEFGANASNDVVLELLSIFQGKREVQEYLKTKESKNFRWTALGTSILLDWSLANGICGYDIDSRTATIWDDGNKPFAMITAKQMGQAVISVLRHPDRAANQYLLVASVVTTQNEILSSLERATASKWTVIYTSTEEKLREATDRINKGDFGGFYTMGTASMYAVKEGLGSDYTKEEKFANGLLELKMERLEDIVNEAVRLKMIKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8LT14</accession>
    <name>B8LT14_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_069420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340909.1">
        <property type="nucleotide sequence ID" value="XM_002340868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LT14"/>
    <dbReference type="STRING" id="441959.B8LT14"/>
    <dbReference type="GeneID" id="8103942"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_069420"/>
    <dbReference type="eggNOG" id="ENOG502S5A2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1994127_0_0_1"/>
    <dbReference type="InParanoid" id="B8LT14"/>
    <dbReference type="OrthoDB" id="5331396at2759"/>
    <dbReference type="PhylomeDB" id="B8LT14"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849:SF1">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="125" mass="13849" checksum="A5C97A65D77067EA" modified="2009-03-03" version="1">MFRPSMTSLRAGRVIAPSPAPAMPRMFATSSLLRTDISSSALPKQKPVGAFRGGIFGFLLGSVAAGVSVYYYVLKEYRVSNELLTDDIYVRGCRIPIFFYAWVLLNTNSCLGPSKRFTKTTQIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B8LT63</accession>
    <name>B8LT63_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Small nucleolar ribonucleoprotein complex subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_069850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat UTP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340958.1">
        <property type="nucleotide sequence ID" value="XM_002340917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LT63"/>
    <dbReference type="FunCoup" id="B8LT63">
        <property type="interactions" value="1072"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LT63"/>
    <dbReference type="GeneID" id="8107650"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_069850"/>
    <dbReference type="eggNOG" id="KOG2055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011055_1_0_1"/>
    <dbReference type="InParanoid" id="B8LT63"/>
    <dbReference type="OMA" id="KIRMWEI"/>
    <dbReference type="OrthoDB" id="1935146at2759"/>
    <dbReference type="PhylomeDB" id="B8LT63"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000292">
        <property type="term" value="P:RNA fragment catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000549">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045161">
        <property type="entry name" value="Utp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359">
        <property type="entry name" value="WD-REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="602"/>
            <end position="630"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="209"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED23571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="630" mass="69403" checksum="6565AC7EE6CD0E1F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTU1</accession>
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        <submittedName>
            <fullName evidence="6">MFS monosaccharide transporter, putative</fullName>
        </submittedName>
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        <name evidence="6" type="ORF">TSTA_070880</name>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="protein sequence ID" value="EED23683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002341029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTU1"/>
    <dbReference type="STRING" id="441959.B8LTU1"/>
    <dbReference type="GeneID" id="8105957"/>
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    <dbReference type="eggNOG" id="ENOG502QT45">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006746_1_0_1"/>
    <dbReference type="InParanoid" id="B8LTU1"/>
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    <dbReference type="OrthoDB" id="546893at2759"/>
    <dbReference type="PhylomeDB" id="B8LTU1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF13">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06630)-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
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        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
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            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
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            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
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            <end position="223"/>
        </location>
    </feature>
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            <end position="428"/>
        </location>
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            <end position="469"/>
        </location>
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            <end position="495"/>
        </location>
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        </location>
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        </location>
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    </feature>
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            <end position="283"/>
        </location>
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            <begin position="826"/>
            <end position="841"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED23683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="910" mass="98982" checksum="529C6CAE8776B11E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTW1</accession>
    <name>B8LTW1_TALSN</name>
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        <recommendedName>
            <fullName evidence="7">37S ribosomal protein S25, mitochondrial</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">TSTA_071870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3 7">Component of the mitochondrial small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS23 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EED23791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002341137.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="B8LTW1">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LTW1"/>
    <dbReference type="GeneID" id="8103895"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_071870"/>
    <dbReference type="eggNOG" id="ENOG502RZQQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081350_0_0_1"/>
    <dbReference type="InParanoid" id="B8LTW1"/>
    <dbReference type="OMA" id="ENWKIWA"/>
    <dbReference type="OrthoDB" id="5542239at2759"/>
    <dbReference type="PhylomeDB" id="B8LTW1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016939">
        <property type="entry name" value="Ribosomal_mS23_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009864"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR029764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED23791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="264" mass="30773" checksum="9B3481C9B5F28B88" modified="2009-03-03" version="1">MGKYNLTALRVRQTALRQRANGKIDKLPEWVDIVGDIPPAQVVVRHQPIQHEYLRQRVRTVPGTSKLEVYFESINQRRTNRNKKPSKLFQPLKIKYEEDQLRKEFFRDHPWELARPRIVLEKSGKDFENYDWSRIQQPGKRLDGESVVQRQLWLLNNVPDMTKTAAYDIARREFYRLRLRQEIEQRVAAEEAEATGAVFGPRMLDISMELEGKVYEDWKVWAKTQAQIMDQKTAAFVGAPEVAIPPDDSKVSVMEAEVEVEAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTY0</accession>
    <name>B8LTY0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Only prolin and serin are matching in the corresponding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_072040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341197.1">
        <property type="nucleotide sequence ID" value="XM_002341156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTY0"/>
    <dbReference type="STRING" id="441959.B8LTY0"/>
    <dbReference type="GeneID" id="8103925"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_072040"/>
    <dbReference type="eggNOG" id="ENOG502SJFJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020684_0_0_1"/>
    <dbReference type="InParanoid" id="B8LTY0"/>
    <dbReference type="OMA" id="KIPRLHD"/>
    <dbReference type="OrthoDB" id="3882058at2759"/>
    <dbReference type="PhylomeDB" id="B8LTY0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="54209" checksum="565403F3A352B696" modified="2009-03-03" version="1">MATDRGRKGRPHPLQTPTAPASVYTDSSAAVSPALSSFSSSSRLQNKVFSSSVSSLLPSPSMGITMERTGSLPIQLADVKEEQNRDIEDDYFGFDQVMFEPYEMTSDVYDLNDNPTYYSETESPKRLRSESLSSRGLSRFGSGIQSMSSRWASMARSSEGTYVTDILDDELRSRANSAASSTSQITSLSQDALPMARNSQDQARHSGHSLGAISIEKASSVAFDEEDEVGAKASTPLLPPVWTEYPFTTPSSEVASPLQSPSVADVFDEDTVPAMTSSRTSIHRSPPLSSKPSVASLTTRTRGMTLRTTISGEGAPPLVLTEGDDEWSFKLGHANFTIHPEPYIPETSDATTFRQFRDDWDLARTNYAKHLVRTGEHYGETSMIYKFTKEKWEAIEEEWKENLETIVTNDVKFGAILGLTKSNMSPAETIKIPRLHDNEKFPELGDEEIVGPMSVAPAIHSAIRCKSPKRRNVFRFLHGLVSRPAPGITATRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUR4</accession>
    <name>B8LUR4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_073110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341308.1">
        <property type="nucleotide sequence ID" value="XM_002341267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUR4"/>
    <dbReference type="STRING" id="441959.B8LUR4"/>
    <dbReference type="GeneID" id="8110237"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_073110"/>
    <dbReference type="eggNOG" id="KOG1437">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067857_0_0_1"/>
    <dbReference type="InParanoid" id="B8LUR4"/>
    <dbReference type="OMA" id="YATNNTQ"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="PhylomeDB" id="B8LUR4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877080" description="FAS1 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="19"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="178"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED23921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="343" mass="36798" checksum="178BF792D92FB6DE" modified="2009-03-03" version="1">MASFAFILCTLAILWQRVLAVAVFEALQSSNAGLFAQWVEQDQGLASLYSSSKVKTVFAPVDDAFRAYNQTGHLSQLRRVLVRQAGLPSEAGLQHVSGNLNHLNEQSPDSNRTQPVVGLPSSSNGASGVSSRQKRQSNNSTTQTLRFYSGLGNSVSVIHANIPYDGGLIHTLDGFFTLPQSWDDTFAYTNTTSFSSGLNRTGLASIISNPKGATIFSTPNEVYDRSIQQNITTASLTSTLSNHVIPNFLGYTPNLANGTILTTQSGNNLTVKIIDGEWFINNAKIIGSDQICSYGVAHIVDSIIETSTSPSVPAYTGMAATHKKVEKAGVIASIAYAFLAWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8LV16</accession>
    <name>B8LV16_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_061280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340024.1">
        <property type="nucleotide sequence ID" value="XM_002339983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LV16"/>
    <dbReference type="STRING" id="441959.B8LV16"/>
    <dbReference type="GeneID" id="8107607"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_061280"/>
    <dbReference type="eggNOG" id="ENOG502SU4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1023692_0_0_1"/>
    <dbReference type="InParanoid" id="B8LV16"/>
    <dbReference type="OMA" id="TEPEECC"/>
    <dbReference type="OrthoDB" id="9997739at2759"/>
    <dbReference type="PhylomeDB" id="B8LV16"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="164"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="30616" checksum="C6E9929DBE58CB68" modified="2009-03-03" version="1">MNSKSYEERPLTPMSRCIPVGLPAETMQTAAATFAQTEFHDCDELLGDAVFMHAKTYCFAHRFLISRLEVLALQRLTQVLLTNNTSRGPFYSRLADAIHLVYESTPKSTQFDDPAQKLLAQYVALNFISIPTESLETVVSAGGEFMVDVAQKLAQRIATSGRSTESLEEYIDELKTKVNALELEGQKQRSLLEKTEKEIREWESWNRGISGKYIPTLQGVCVTAEQDVIQKQVRFDIPEATEPEECCSEIGLRDEGKSLVTWSRDNVGARLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8LV36</accession>
    <name>B8LV36_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_061470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340044.1">
        <property type="nucleotide sequence ID" value="XM_002340003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LV36"/>
    <dbReference type="FunCoup" id="B8LV36">
        <property type="interactions" value="1332"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LV36"/>
    <dbReference type="GeneID" id="8110218"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_061470"/>
    <dbReference type="eggNOG" id="ENOG502SHVI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8LV36"/>
    <dbReference type="OrthoDB" id="4223376at2759"/>
    <dbReference type="PhylomeDB" id="B8LV36"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF49">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="278"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED22657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="747" mass="83668" checksum="5911E08EA877B6D0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVB1</accession>
    <name>B8LVB1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_066140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340548.1">
        <property type="nucleotide sequence ID" value="XM_002340507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVB1"/>
    <dbReference type="GeneID" id="8104414"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_066140"/>
    <dbReference type="HOGENOM" id="CLU_1929005_0_0_1"/>
    <dbReference type="InParanoid" id="B8LVB1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED23161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="131" mass="15216" checksum="8F628B711F35A94B" modified="2009-03-03" version="1">MAITRQQELRKGMKPHRVSKRTIATKKSPNISNKYKLSSRIIDLIKQNATDEDIKSHIAIEEIARDCNYKTVWDWAEFLLWLYKNGGMSLDTKTSKSHQTVEDLMRKWEIPTPIKTVMRDIKFGKNLGGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVN8</accession>
    <name>B8LVN8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_075400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341555.1">
        <property type="nucleotide sequence ID" value="XM_002341514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVN8"/>
    <dbReference type="GeneID" id="8106227"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_075400"/>
    <dbReference type="eggNOG" id="ENOG502T8V3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101420_0_0_1"/>
    <dbReference type="InParanoid" id="B8LVN8"/>
    <dbReference type="OMA" id="PSPWTEM"/>
    <dbReference type="OrthoDB" id="4588567at2759"/>
    <dbReference type="PhylomeDB" id="B8LVN8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED24168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="193" mass="21227" checksum="3FC53D312F350DA5" modified="2009-03-03" version="1">MQPKHTVSPSATLEPSPMADISLSLRTAFMDNAHYRRESDSLSTSALSSASGSPTSSPTSAWPFRKHRFSGSHTTEPSSRDRSRSPYASIIPFSFRRSSPFFLRRRPSAVDLALSEERSRCDEDVIERVGLSMMEPRPVDPIPIAMDLNSNLLSDMASQRSSYAPSSQGSIRGISQQPRYVMGGIIEVMEGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVY5</accession>
    <name>B8LVY5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_077180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341738.1">
        <property type="nucleotide sequence ID" value="XM_002341697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVY5"/>
    <dbReference type="STRING" id="441959.B8LVY5"/>
    <dbReference type="GeneID" id="8109465"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_077180"/>
    <dbReference type="eggNOG" id="ENOG502S1A6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_1_0_1"/>
    <dbReference type="InParanoid" id="B8LVY5"/>
    <dbReference type="OMA" id="LCHHGGE"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="PhylomeDB" id="B8LVY5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF5">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="49"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED24351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="362" mass="39841" checksum="BE1ECEF80774E838" modified="2009-03-03" version="1">MPLNASFDGPAGAAAKVSIIDSGFRLSGLPTSMLLTPSVEYYEKLPELGSWSFLVESSKGRKVLFDLGGPSDISLFPPQVAEAVEKADAKIEVTRTVADILIENGIEPAHIDSVILSHGHWDHVGDITVFPSTTELVVGPGFKEVYYPGYPTKPDVELSERYFEGRNVREIDFSSGNKSCIKYGAFRAIDFFGDGSFFLLDTPGHAVGHIAGLARTTTSPDTFIFMGGDVCHHGGEIRPSPYLPIPSQVRSFHSSSLNSHHTSYLDGDLYREWNIQRGRKPNDTFFDPILAVDISQAIQSIKEVQEADAQDNVFFVFAHDMQICGVVDFFPESANNWKSKEWKGKALWSFLGDFTPAALSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8LW72</accession>
    <name>B8LW72_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeobox transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_074790</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the engrailed homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341487.1">
        <property type="nucleotide sequence ID" value="XM_002341446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LW72"/>
    <dbReference type="STRING" id="441959.B8LW72"/>
    <dbReference type="GeneID" id="8104200"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_074790"/>
    <dbReference type="eggNOG" id="ENOG502RC6G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022031_0_0_1"/>
    <dbReference type="InParanoid" id="B8LW72"/>
    <dbReference type="OMA" id="MDYEEYA"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="PhylomeDB" id="B8LW72"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000171">
        <property type="entry name" value="Homeobox transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050720">
        <property type="entry name" value="Engrailed_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341">
        <property type="entry name" value="HOMEOBOX PROTEIN ENGRAILED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341:SF6">
        <property type="entry name" value="HOMEOBOX PROTEIN INVECTED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="61"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="63"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="114"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="253"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="491"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="641"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="253"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="298"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED24100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="725" mass="79796" checksum="812DA8F939924FE0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWQ8</accession>
    <name>B8LWQ8_TALSN</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="6" type="ORF">TSTA_078180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP5 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EED24455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341842.1">
        <property type="nucleotide sequence ID" value="XM_002341801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWQ8"/>
    <dbReference type="FunCoup" id="B8LWQ8">
        <property type="interactions" value="812"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LWQ8"/>
    <dbReference type="GeneID" id="8101126"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_078180"/>
    <dbReference type="eggNOG" id="KOG4547">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009553_0_0_1"/>
    <dbReference type="InParanoid" id="B8LWQ8"/>
    <dbReference type="OMA" id="CEHAVNP"/>
    <dbReference type="OrthoDB" id="30195at2759"/>
    <dbReference type="PhylomeDB" id="B8LWQ8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
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        <property type="entry name" value="U3_snoRNA-assoc_WDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="5">
        <location>
            <begin position="580"/>
            <end position="683"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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            <end position="519"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="712"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="509"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
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            <end position="739"/>
        </location>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="768"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
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            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="849"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED24455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="859" mass="92886" checksum="8DC9919B7D260A3C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXX5</accession>
    <name>B8LXX5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_062770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002340136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXX5"/>
    <dbReference type="STRING" id="441959.B8LXX5"/>
    <dbReference type="GeneID" id="8106643"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_062770"/>
    <dbReference type="eggNOG" id="ENOG502S7JX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111642_2_0_1"/>
    <dbReference type="InParanoid" id="B8LXX5"/>
    <dbReference type="OMA" id="FEWRHPD"/>
    <dbReference type="OrthoDB" id="2320332at2759"/>
    <dbReference type="PhylomeDB" id="B8LXX5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08863">
        <property type="entry name" value="SRPBCC_DUF1857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015075">
        <property type="entry name" value="AtaL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08982">
        <property type="entry name" value="AtaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED22790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="168" mass="18744" checksum="F8B079925ABC5FF0" modified="2009-03-03" version="1">MSPTNNIAFTTPINPPGVSPVLKKEQVWAGLLLKIRCAEKFIPNAIESTTVISESKDPSTGNIVTVREVVFREQQRKVKETVTAYKDARVDFVQPDGTFIGNIISEGASGELYMTYVFEWHHPGAPEEELRAFYVKEKGVAQHSVEGTVDVIRKLVTEGKLDEHRSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYK8</accession>
    <name>B8LYK8_TALSN</name>
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        <submittedName>
            <fullName evidence="5">BTB domain and ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_067940</name>
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    <organism evidence="5 6">
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        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002340712.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LYK8"/>
    <dbReference type="GeneID" id="8104685"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_067940"/>
    <dbReference type="eggNOG" id="KOG0783">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002285_0_0_1"/>
    <dbReference type="InParanoid" id="B8LYK8"/>
    <dbReference type="OMA" id="FEFVLRY"/>
    <dbReference type="OrthoDB" id="1893551at2759"/>
    <dbReference type="PhylomeDB" id="B8LYK8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18500">
        <property type="entry name" value="BACK_IBtk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF2">
        <property type="entry name" value="INHIBITOR OF BRUTON TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="353"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="407"/>
            <end position="467"/>
        </location>
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        </source>
    </evidence>
    <sequence length="1696" mass="186279" checksum="99ECD0566705FF93" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
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</entry>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="Proteomes" id="UP000001745">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
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    </dbReference>
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    <dbReference type="PROSITE" id="PS50033">
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        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        <location>
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        <location>
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    </feature>
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        </location>
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        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED21702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="522" mass="58322" checksum="27A1200977F34596" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZI2</accession>
    <name>B8LZI2_TALSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_093100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002478982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZI2"/>
    <dbReference type="GeneID" id="8102554"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_093100"/>
    <dbReference type="HOGENOM" id="CLU_706324_0_0_1"/>
    <dbReference type="InParanoid" id="B8LZI2"/>
    <dbReference type="OrthoDB" id="3911117at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="391" mass="44784" checksum="E77931E025DC75CB" modified="2009-03-03" version="1">MEVVEDITNSSENISITPFGLQEEQGQLRHNYRRYGEVDAALLTQTPGVVRIDTVLHRRRGILITHDTYDYFRLSFEDDDHARCFLGEILANVSASDHVVRLSELQLEEINSQWDENPRVINPRFTPANLPLIMSTKLVYSLSTKWEIVKTHYYIALSETMLDQLCEEAICSASLNGFIKVTSLPIMKDIPDIRQPKMSVEHELTQALISASLTERYKPPICSLVERLINMIKVGRRERSEPFLNISKNWAPRFLPRESMNKISQAIRFVHIENHDPDTLDKTDRQDGSDNADKASNALKPSNSSIRGMRAFLVRRPVGKTSRTCLDKALAKCIRESTTARTLFDRGERSRTKLDSFADKLFYCANRCYTGDTRSHSEQCSSRGMVEFLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZY6</accession>
    <name>B8LZY6_TALSN</name>
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        <submittedName>
            <fullName evidence="3">Dienelactone hydrolase family protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">TSTA_081510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED20918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002477836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZY6"/>
    <dbReference type="STRING" id="441959.B8LZY6"/>
    <dbReference type="GeneID" id="8104789"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_081510"/>
    <dbReference type="eggNOG" id="KOG3043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_327939_0_0_1"/>
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    <dbReference type="OrthoDB" id="5412996at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="47"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="781"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED20918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="877" mass="100054" checksum="360250D6D14303A7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8M065</accession>
    <name>B8M065_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DNA repair protein Rad4, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_083940</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478125.1">
        <property type="nucleotide sequence ID" value="XM_002478080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M065"/>
    <dbReference type="FunCoup" id="B8M065">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M065"/>
    <dbReference type="GeneID" id="8101487"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_083940"/>
    <dbReference type="eggNOG" id="KOG2179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003639_1_1_1"/>
    <dbReference type="InParanoid" id="B8M065"/>
    <dbReference type="OMA" id="IPEWLMS"/>
    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="PhylomeDB" id="B8M065"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2460:FF:000001">
        <property type="entry name" value="DNA repair protein Rad4 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.290">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="7">
        <location>
            <begin position="503"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="566"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="631"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="754"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="859"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="813"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="860"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED21162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="973" mass="109453" checksum="AAE6337E2777169D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8M094</accession>
    <name>B8M094_TALSN</name>
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        <submittedName>
            <fullName evidence="4">Cellular morphogenesis protein (Bud22), putative</fullName>
        </submittedName>
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        <name evidence="4" type="ORF">TSTA_084220</name>
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    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="441959.B8M094"/>
    <dbReference type="GeneID" id="8101515"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_084220"/>
    <dbReference type="eggNOG" id="ENOG502S6Z4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029647_0_0_1"/>
    <dbReference type="InParanoid" id="B8M094"/>
    <dbReference type="OMA" id="ALWEKKF"/>
    <dbReference type="OrthoDB" id="3364872at2759"/>
    <dbReference type="PhylomeDB" id="B8M094"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037393">
        <property type="entry name" value="Bud22/SRFB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015158">
        <property type="entry name" value="Bud22_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325:SF1">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09073">
        <property type="entry name" value="BUD22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bud22" evidence="3">
        <location>
            <begin position="32"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="419"/>
            <end position="429"/>
        </location>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <begin position="462"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF09073"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED21191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="476" mass="52898" checksum="FE582DF722C0042D" modified="2009-03-03" version="1">MPKRKHSEVDLSGDGDEKLNRVKATRLGHKFERGSQLLFRALKTARGFERQKLGRRQKTAKGDGDSKTLERLEKEVHALKALDLEEIAQRYLLKQLNKTKRIAESPEFVRLEKSINASFDVGPGPRDPAEANVTARLFKSNPVQTALPDILTDIRTLLGVDEIPTRKQQQKHVKKEATQNEETAKEPDEPQIETDMRSHKMEGRNSRAEDYLNDVNMDDVSDDGDSLDLSQFDARLASASEGSNSEEEEFGYSRIKITSPSNRDNHEIPDDISISSSPASSIISQNPSESPLPTSVSPPKTHKKEKSDEQRPKNTTFLPSLMMGGYWSGSESDPEEDEVAAAAAGSRPQRKNRMGQQARRALWEKKYGARAKHLQEQEKNSKKSKNKDSGWDARRGATDENDKPKWAAGAGKRGISSLGKRDNHARDSGNGKATMTNNKSSSSAATAGLHPSWEAARKAKQQKAQASFQGKKITFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0M5</accession>
    <name>B8M0M5_TALSN</name>
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        <submittedName>
            <fullName evidence="7">NCS1 allantoate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_086390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
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        <property type="protein sequence ID" value="EED21408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478371.1">
        <property type="nucleotide sequence ID" value="XM_002478326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0M5"/>
    <dbReference type="GeneID" id="8110047"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_086390"/>
    <dbReference type="eggNOG" id="KOG2466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021555_4_1_1"/>
    <dbReference type="InParanoid" id="B8M0M5"/>
    <dbReference type="OMA" id="FNWLYGF"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="PhylomeDB" id="B8M0M5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="382"/>
        </location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED21408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="541" mass="59545" checksum="B873A1D67CDC4D2F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0Z3</accession>
    <name>B8M0Z3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_090120</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478736.1">
        <property type="nucleotide sequence ID" value="XM_002478691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0Z3"/>
    <dbReference type="STRING" id="441959.B8M0Z3"/>
    <dbReference type="GeneID" id="8108100"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_090120"/>
    <dbReference type="eggNOG" id="ENOG502SVPD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_543982_0_0_1"/>
    <dbReference type="InParanoid" id="B8M0Z3"/>
    <dbReference type="OMA" id="QDELQMP"/>
    <dbReference type="OrthoDB" id="5423493at2759"/>
    <dbReference type="PhylomeDB" id="B8M0Z3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
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        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="462" mass="50611" checksum="7D1F87AD0AF0BCBB" modified="2009-03-03" version="1">MPRPPARRARTVRQAPEKAEDESQGGNIATPRRPGHDENNNDAHRADRPDLTPTRDSNENVIASSPAGNTTTASIRPPTRARGYSSTLSLVGRKGDFNSRIGSTPGFESSVLSNFKKRSRQPSLLQMMQAHDDENSSDFDDEDFLGGFSPQDESTPLNIARVSNAAERQLPASPSPSRPPQVVPSPSSRESRKRKRQSEAVNDNHAEPGSPSARSSSSLSTLTPTPKSPVAGTRAESPSFTMATPMSSSTASPSRLMIVGKQITAATEKTAAAESLPKLTTLSIQTRFLPQRRIRRHQRTDDNEDEDGIDSANEDSDEDELTREVMRRPQRSRKKGLSNATFGKTNAKPSKPNRGGRKNKRGNTKATTNAVDPQGSKSQRTYSRQKPQAADKENDLSDNSSILSSPPPSEDLRESDSEIPSRASKRVTSRELQEAARKFAEVDKWQMDFEDVPDSEISSPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8M166</accession>
    <name>B8M166_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_082410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477971.1">
        <property type="nucleotide sequence ID" value="XM_002477926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M166"/>
    <dbReference type="GeneID" id="8107699"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_082410"/>
    <dbReference type="HOGENOM" id="CLU_1273014_0_0_1"/>
    <dbReference type="InParanoid" id="B8M166"/>
    <dbReference type="OrthoDB" id="4369471at2759"/>
    <dbReference type="PhylomeDB" id="B8M166"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="205" mass="22882" checksum="D3A54969A2F68A6B" modified="2009-03-03" version="1">MPKIITKTDQVNIKMPRPATPKPGFSLLRLNNSKKPHNIASLSTQAKINLINSIAQDIEGCIWAVGHYVKLGVLDSTHTLGFDQVLNDIYKDERSDNEEVLLWALRSMERYKKQARAERKRAKRLDAKLRRERGEEQGNGDHSDDENPIDSDSSTAYPEMKSMKRQGLQSSQGDQTQDVADTVMTSPPPSPTQGCMDVDGSSAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1G7</accession>
    <name>B8M1G7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_091030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478826.1">
        <property type="nucleotide sequence ID" value="XM_002478781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1G7"/>
    <dbReference type="STRING" id="441959.B8M1G7"/>
    <dbReference type="GeneID" id="8101593"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_091030"/>
    <dbReference type="eggNOG" id="ENOG502QWIS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023417_2_0_1"/>
    <dbReference type="InParanoid" id="B8M1G7"/>
    <dbReference type="OMA" id="DPDPRAF"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="PhylomeDB" id="B8M1G7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED21863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="38218" checksum="1CA3C7EA18DA428D" modified="2009-03-03" version="1">MSFANPDASGIQESTWQHYAVVINQLLREFRDITSASQEKSLHLSVTLLVLCHVEIISGNLKGAIFSHLRACRQLILSLLQRSPPRMQSTDQELLGFALEFYAYFALMTNITPYGKNQAHTIPLDNFVTSLSPLHEYSTFGALMSCGHDLFEAIASISQLFSQRLYEQHRQQAEPSAPTMAMYEALLVYLSNWQFTGPTNKWSDPREQTWAGEIYKNALLIYLKASICGSVIDNPKVICEIQEHVDEILQLLTRLNCSPYGTIMMWPCMIAGSCLIKTTQRDFMQKALRTSRWKMCHVKQAAEILESLWRDNVKCAFGPYGLHYIMQKHGISFCMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8M258</accession>
    <name>B8M258_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Arp2/3 complex subunit (Arp2), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_087580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478485.1">
        <property type="nucleotide sequence ID" value="XM_002478440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M258"/>
    <dbReference type="FunCoup" id="B8M258">
        <property type="interactions" value="1072"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M258"/>
    <dbReference type="GeneID" id="8100887"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_087580"/>
    <dbReference type="eggNOG" id="KOG0677">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027965_0_0_1"/>
    <dbReference type="InParanoid" id="B8M258"/>
    <dbReference type="OMA" id="WEDMQHL"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="PhylomeDB" id="B8M258"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030476">
        <property type="term" value="P:ascospore wall assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10220">
        <property type="entry name" value="ASKHA_NBD_Arp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000005">
        <property type="entry name" value="Actin-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED21522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="390" mass="43839" checksum="FC8AB88480B8A9D8" modified="2009-03-03" version="1">MTDAPIVLDGGTGFLKVGYAAQNFPEHQFPSIVGRPILRSEEQGESDIVLKDIMCGDEAAAARSMLQISYPMENGIVKKWDDMQHLWNYTFYDKMKIDPTGRKILLTEPPMNPLKNRQTMAEVMLEGYGFGGVYVAIQAVLALYAQGLSSGVVVDSGDGVTHIVPVFESTVLNHHIRRLDVAGRDVTRNLIALLLRRGYALNRTADFETVRQIKEKLCYVSYDLELDQRLSEDTTVLVESYTLPDGRVIRVGSERFEAPECLFQPHLVDVDQAGIAELLFNTIQGTDMDVRSSLYKAIVLSGGSSMYPGLPSRLEKELKQLWLTRVLQGNPERLNKFKVRIEDPPRRRHMVFLGGAVLANLIADKEDMWVTKAEWEEQGVRALDKLGPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2A0</accession>
    <name>B8M2A0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_088000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478527.1">
        <property type="nucleotide sequence ID" value="XM_002478482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2A0"/>
    <dbReference type="STRING" id="441959.B8M2A0"/>
    <dbReference type="GeneID" id="8101092"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_088000"/>
    <dbReference type="eggNOG" id="ENOG502RM4B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035914_1_2_1"/>
    <dbReference type="InParanoid" id="B8M2A0"/>
    <dbReference type="OMA" id="LMIRDEC"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="PhylomeDB" id="B8M2A0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF127">
        <property type="entry name" value="TYROSINASE COPPER-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="2">
        <location>
            <begin position="30"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED21564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="266" mass="30044" checksum="5906206E1CC10C2E" modified="2009-03-03" version="1">MEEKLSYIGAAQCLARTPSASLRNDNASIHDELALLHGKFGNYSHNAAPFLPWHRYFIYVYEQALRENCGYQGSLPYWDWTLDYQDLSRAPVWNLIDGFGPSRDEYGSEGVAGGHCVVSGPFAGLMPTFFEGVRDPHCLSRGILDKETVRRVGNLTVRPTVLARLANTNGSYFDFLIELEHTSHLVIPYILQGDFSKITAPNEPRQSEYNGPSRNDSSVEGVLRDFLDSGDFLPMWPRVEDVMDTEGGLLCYQYDTTVWEESWVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3U0</accession>
    <name>B8M3U0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Actin-binding protein Fragmin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_038880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481117.1">
        <property type="nucleotide sequence ID" value="XM_002481072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3U0"/>
    <dbReference type="STRING" id="441959.B8M3U0"/>
    <dbReference type="GeneID" id="8107930"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_038880"/>
    <dbReference type="eggNOG" id="KOG0443">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002568_0_1_1"/>
    <dbReference type="InParanoid" id="B8M3U0"/>
    <dbReference type="OMA" id="KKAGQKC"/>
    <dbReference type="OrthoDB" id="6375767at2759"/>
    <dbReference type="PhylomeDB" id="B8M3U0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11290">
        <property type="entry name" value="gelsolin_S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF130">
        <property type="entry name" value="SEVERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gelsolin-like" evidence="3">
        <location>
            <begin position="61"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="3">
        <location>
            <begin position="147"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED20683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="359" mass="40516" checksum="867BD050B7E6BB90" modified="2009-03-03" version="1">MTELNFGDTNIWLIGTDIDHKVKYNSATTEPAWNNGTIGIQPGLFIWRIEDFHVVPWPKELYGQFYDGDSYIVLYSYTIPRSENGEQAERLAHDIFFWLGAKTTQDEAGTAAYKTVELDEFLHGVATQHREIQLHPSDEFLTAHGHSVVVHEVDPTWQSLDDGDVFILEKDDKIWVWQGKDASPMEKAKAAQVVNELTLAKHIDVEVLAQTEARSKIVVDLLGGGNTDQSYFRTGRPIHNSRPSPASSLLPARPPRLFRIVPTESGQFQFELDKEGGTIRLSDLDSNDIFIFDTGRKIWVWEGQYVNTHVKDAWKLCTGAYLRYLQQESQAPEVIAATPVAKVKEGNENAAFFQSISAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4C1</accession>
    <name>B8M4C1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS lactose permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_024400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479550.1">
        <property type="nucleotide sequence ID" value="XM_002479505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4C1"/>
    <dbReference type="GeneID" id="8097971"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_024400"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="InParanoid" id="B8M4C1"/>
    <dbReference type="OMA" id="RWRFLQV"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="PhylomeDB" id="B8M4C1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000217">
        <property type="entry name" value="MFS lactose permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF36">
        <property type="entry name" value="LACTOSE PERMEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="61"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED19116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="547" mass="60253" checksum="3D13116D0245DCF8" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8M561</accession>
    <name>B8M561_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BAR adaptor protein RVS167, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_029430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480101.1">
        <property type="nucleotide sequence ID" value="XM_002480056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M561"/>
    <dbReference type="FunCoup" id="B8M561">
        <property type="interactions" value="320"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M561"/>
    <dbReference type="GeneID" id="8106510"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_029430"/>
    <dbReference type="eggNOG" id="KOG3771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025518_0_1_1"/>
    <dbReference type="InParanoid" id="B8M561"/>
    <dbReference type="OMA" id="QEYDYYN"/>
    <dbReference type="OrthoDB" id="2159336at2759"/>
    <dbReference type="PhylomeDB" id="B8M561"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07599">
        <property type="entry name" value="BAR_Rvs167p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000048">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000189">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF1">
        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="8">
        <location>
            <begin position="17"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="363"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="282"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="149"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED19667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="422" mass="47729" checksum="A7014585EB48B321" modified="2009-03-03" version="1">MSLKGLGKSFARAPQTFKARFNIGENTKDPVYIDAERRFQELEKETKKLHDDSKKYFEAINGMLNHQIEFSKAMTELYKPISGRASDPSTYTIEGNPEGIQACEEYEAIVRDLQETLAPELEMIETRVISPANELLDIIKIVRKVTVKREHKKLDYDRHRATLKKLEEKKDKSLKDEKALYKAENDVEQATQEYNHYNDLLKEELPKLFQLEAEFIGPLFQSFYYMQLNVFYTLHEKMQGVNIGYFDLTRDIEEAYEAKKGDAKERAEELSIVHFKTTGGRRSTASKFSSAKDKLSENRLSSSSARRNSTTEKPPPPYSPTGAAGTTLIGRANSTGGSVLAAAAKSKPAPPPPKPKPGYLAKPNVETVTALYDYEAQAHGDLSFSAGDVIEIVQRTNNENEWWTGRLHGREGQFPGNYVKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5G2</accession>
    <name>B8M5G2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSTA_030350</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterohexamer; composed of 3 copies of TIM9 and 3 copies of TIM10, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Peripheral membrane protein</topology>
            <orientation evidence="1 14">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480202.1">
        <property type="nucleotide sequence ID" value="XM_002480157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5G2"/>
    <dbReference type="FunCoup" id="B8M5G2">
        <property type="interactions" value="898"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M5G2"/>
    <dbReference type="GeneID" id="8101714"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_030350"/>
    <dbReference type="eggNOG" id="KOG3479">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141397_3_0_1"/>
    <dbReference type="InParanoid" id="B8M5G2"/>
    <dbReference type="OMA" id="QDFLRMY"/>
    <dbReference type="OrthoDB" id="1551503at2759"/>
    <dbReference type="PhylomeDB" id="B8M5G2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000008">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050673">
        <property type="entry name" value="Mito_inner_translocase_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13172">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="15">
        <location>
            <begin position="15"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EED19768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="90" mass="10502" checksum="25DA9E3B103D337D" modified="2009-03-03" version="1">MDGLNASEQRELAARMERKQMKEFMQMYSRLVQRCFDDCVNDFTTKSLHSREEGCVLRCVDKYLKSSARLGERFQEQNAAMMQSGQLPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5H7</accession>
    <name>B8M5H7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_030490</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize pre-autophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG17 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480217.1">
        <property type="nucleotide sequence ID" value="XM_002480172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5H7"/>
    <dbReference type="STRING" id="441959.B8M5H7"/>
    <dbReference type="GeneID" id="8101728"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_030490"/>
    <dbReference type="eggNOG" id="ENOG502RYHP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028356_0_0_1"/>
    <dbReference type="InParanoid" id="B8M5H7"/>
    <dbReference type="OMA" id="THVWRAN"/>
    <dbReference type="OrthoDB" id="1937984at2759"/>
    <dbReference type="PhylomeDB" id="B8M5H7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007240">
        <property type="entry name" value="Atg17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28005">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28005:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Autophagy protein ATG17-like" evidence="10">
        <location>
            <begin position="55"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="281"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED19783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="621" mass="68512" checksum="7D549AA67D2670B5" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5P5</accession>
    <name>B8M5P5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxisomal membrane protein receptor Pex19, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_031980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480373.1">
        <property type="nucleotide sequence ID" value="XM_002480328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5P5"/>
    <dbReference type="FunCoup" id="B8M5P5">
        <property type="interactions" value="275"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M5P5"/>
    <dbReference type="GeneID" id="8099811"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_031980"/>
    <dbReference type="eggNOG" id="KOG3133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043063_2_1_1"/>
    <dbReference type="InParanoid" id="B8M5P5"/>
    <dbReference type="OMA" id="EMLYEPL"/>
    <dbReference type="OrthoDB" id="21292at2759"/>
    <dbReference type="PhylomeDB" id="B8M5P5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033328">
        <property type="term" value="F:peroxisome membrane targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.900">
        <property type="entry name" value="Pex19, mPTS binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006708">
        <property type="entry name" value="Pex19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038322">
        <property type="entry name" value="Pex19_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774:SF2">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04614">
        <property type="entry name" value="Pex19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="375" mass="41233" checksum="99FE158F42F6E02E" modified="2009-03-03" version="1">MASTDQAGETADKRDEQKTPLAVENKAELEVNDTTKLMTDDEGSEWEDLDEVLDDFSGPKRPTQSTASLSSKPSHSQNDASEDAFMKQLEADMLAQLLGAGGEPSGEGKENAAAPTTKQTEKGALLDDLSFLQNMSEKDLDKFGELLESEGGMTKIVQELFGSDGPPAGDSTKGKDKPVTAAGEPFQDTIQRTLDRMKESGDKITVEAQTNQDKLIDASVMKLMEIMNETATSGGSFNIEEVFSDIIKEMSNKEMLYEPMKEYNVKYGPWLEENKATLSSEDYERFEKQAGVVKKIVERFEAEDYTDEKPECLASIWDLMQQMEACGPPPEDLIKGSMGDGVLPSLTPFLDRNEPEGDKGNKDPDQIPPPECNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5Y9</accession>
    <name>B8M5Y9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSTA_033590</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480550.1">
        <property type="nucleotide sequence ID" value="XM_002480505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5Y9"/>
    <dbReference type="FunCoup" id="B8M5Y9">
        <property type="interactions" value="993"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M5Y9"/>
    <dbReference type="GeneID" id="8097776"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_033590"/>
    <dbReference type="eggNOG" id="KOG0749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_12_0_1"/>
    <dbReference type="InParanoid" id="B8M5Y9"/>
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    <dbReference type="PhylomeDB" id="B8M5Y9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ATP:ADP antiporter activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="ADP,ATP carrier protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
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    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="13"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="118"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="218"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EED20116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="315" mass="33968" checksum="97113D2AB05E32B9" modified="2009-03-03" version="1">MASQGDKTVFGMPGFVVDFLMGGVSAAVSKTAAAPIERVKLLIQNQDEMLRAGRLDRKYGGIMDCFRRTAAAEGVMSLWRGNTANVIRYFPTQALNFAFRDTYKSMFAFKKDRDGYWWWMAGNLASGGAAGATSLLFVYSLDYARTRLANDAKSAKGGGDRQFNGLVDVYKKTLAADGIAGLYRGFSVSVAGIIVYRGLYFGMYDSLKPVILVGPLEGNFLASFLLGWSVTTGAGIASYPLDTIRRRMMMTSGEAVKYKSSFDAARQIAAKEGVKSFFKGAGANILRGVAGAGVLSIYDQVQLVLFGKKFKGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8M618</accession>
    <name>B8M618_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Swollenin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_023530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479452.1">
        <property type="nucleotide sequence ID" value="XM_002479407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M618"/>
    <dbReference type="STRING" id="441959.B8M618"/>
    <dbReference type="GeneID" id="8109535"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_023530"/>
    <dbReference type="eggNOG" id="ENOG502SFAG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_565218_0_0_1"/>
    <dbReference type="InParanoid" id="B8M618"/>
    <dbReference type="OMA" id="GADHCGE"/>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="PhylomeDB" id="B8M618"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.760">
        <property type="entry name" value="Expansin, cellulose-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007112">
        <property type="entry name" value="Expansin/allergen_DPBB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007117">
        <property type="entry name" value="Expansin_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036749">
        <property type="entry name" value="Expansin_CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49590">
        <property type="entry name" value="PHL pollen allergen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50843">
        <property type="entry name" value="EXPANSIN_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50842">
        <property type="entry name" value="EXPANSIN_EG45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877422" evidence="2">
        <location>
            <begin position="23"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="5">
        <location>
            <begin position="25"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Expansin-like EG45" evidence="3">
        <location>
            <begin position="184"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Expansin-like CBD" evidence="4">
        <location>
            <begin position="380"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED19018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="483" mass="50971" checksum="0C4248EB5B2EF1B7" modified="2009-03-03" version="1">MATTLIFVMGLWSGLLWSTTVAQASCAAIWAQCGGSGFSGPSCCETGSTCTQLNSFYSQCTPTTQISSASPTGTNPSSVTSLVPSGSSYTSTTSLSTATATQVPYPAVNSSSCGAWALVENVCCPYYCTSNNESESCTSSCSGGCGSPDASMCKSGTMWGEQTTVGTDESWHYSRSTHFGLTSGGACGFGLYGLCTKGSSTANWTDPMLGDTCNAFCTAYPLLCRDPSNVTLRGNFAAPNGDYYTQFWPSLAAEGNPDNYLSCGECFELIRTKADGTDYTVGEDGYTDPIYLEIVDSCPCSANAKWCCGSGADHCGEIDFKYGCPIPKDSHHMDLSDIAMGRLQGNGSLADGVIPIRYKRVPCPKPGNVYIWLRDGAGPYYFSLSAVNTNGVGSVINVEVQGSGQTGWTALERDPNYSSSRPQERYGAWVVPQGAGPFNVPIGIRITSPDGQQIVNTEMITSFTAPASAPSGFWYIDMGVQFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8M633</accession>
    <name>B8M633_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_023680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479467.1">
        <property type="nucleotide sequence ID" value="XM_002479422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M633"/>
    <dbReference type="STRING" id="441959.B8M633"/>
    <dbReference type="GeneID" id="8109550"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_023680"/>
    <dbReference type="eggNOG" id="ENOG502QUV4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_4_2_1"/>
    <dbReference type="InParanoid" id="B8M633"/>
    <dbReference type="OMA" id="MWPLFEG"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="PhylomeDB" id="B8M633"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002874765" description="FAD-binding PCMH-type domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="184"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED19033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="649" mass="69161" checksum="6D339BDDA5EA64FD" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7L0</accession>
    <name>B8M7L0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAC3/GANP domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_028510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479997.1">
        <property type="nucleotide sequence ID" value="XM_002479952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7L0"/>
    <dbReference type="STRING" id="441959.B8M7L0"/>
    <dbReference type="GeneID" id="8108367"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_028510"/>
    <dbReference type="eggNOG" id="ENOG502RXZN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055649_0_0_1"/>
    <dbReference type="InParanoid" id="B8M7L0"/>
    <dbReference type="OMA" id="VMEWADG"/>
    <dbReference type="OrthoDB" id="2100128at2759"/>
    <dbReference type="PhylomeDB" id="B8M7L0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398:SF1">
        <property type="entry name" value="CSN8_PSMD8_EIF3K DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398">
        <property type="entry name" value="YALI0F14311P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="39789" checksum="5F4494BB8F38162E" modified="2009-03-03" version="1">MSFRGRNAPFRKLESGAGIRTGDTGRSRLRPVSDPLEAVGFPSKGDKTLLDHKAQRAYYDTVVDRYMRFCSSHSHDLEAAWASLPASASADATKNPPSNLPALPIGKPSSKSAHRDGPAESLIAMTESLSLSDKQQPPPKSAVETQRSPAAELSTLLMSLRKLREGILAASSSTPVAFQQQVYIFSIRFSILARHPPSYFSSLRYLLDNLHASSHPLTEHALTEFTSYLILDYACRQNSLTPAYTLLIQAKKKHGFQSHVVDRILNALTHDNWISFWRIHKEVDGYVRAIMGWAADHMTRQALKAAGRTYLSVNVNWLLQTSTGGEGWTWQRLSEKEKLGWHLEGDSVIIRKPRARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8P1</accession>
    <name>B8M8P1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_037720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480988.1">
        <property type="nucleotide sequence ID" value="XM_002480943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8P1"/>
    <dbReference type="STRING" id="441959.B8M8P1"/>
    <dbReference type="GeneID" id="8102148"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_037720"/>
    <dbReference type="eggNOG" id="ENOG502T8K1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018876_0_0_1"/>
    <dbReference type="InParanoid" id="B8M8P1"/>
    <dbReference type="OMA" id="HAIACNG"/>
    <dbReference type="OrthoDB" id="2364732at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED20554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="494" mass="55711" checksum="226204C69EE0280A" modified="2009-03-03" version="1">MANLSPFSNFSQGNSSTFTSPFGFAREIHLAMGPCQFQGNNGFRCTCPSGECTLFSDDPRRPIFCENCGHVMDVHRDYDKRHLPLPMSFSVCIKSLTDILKAAALFSSVLLEIPTMVSPRERLVNGIIDQAEKYRLILVRGTPDCGKMNLVANELLTRRSGEIPVHIMTGWDERQVDKAEGWNEYLMQETVIKGRDWPTSCAYLCSMKLRSLTGIPLYESFDEETTDFNDQNGLGLLLEAEEASDVMKKYTDAVGPPSLSKDLMDELFLISNGHVGCLTALMGVFRRAVELEYQRRHDPQFELGTVRESIFSHPSRLFRYLNDTPFIRGMPNADILQHQDVAKVFKRTVACDEISADDFENAAEIQTLEMIWRNGWLHARKIRSSLYISQQHPSLTPLTGVIHYTTALELAIGAIRGIIIPRHLSDPPRSASGGSLPLEDQYQKEFYRSFYTLLDGRVLISPEYVAKRGKGGGTIDFLLSTKKWGFELLEIAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8P3</accession>
    <name>B8M8P3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_037740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480990.1">
        <property type="nucleotide sequence ID" value="XM_002480945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8P3"/>
    <dbReference type="STRING" id="441959.B8M8P3"/>
    <dbReference type="GeneID" id="8102150"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_037740"/>
    <dbReference type="eggNOG" id="ENOG502SM3D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_22_1"/>
    <dbReference type="InParanoid" id="B8M8P3"/>
    <dbReference type="OMA" id="KRVRVWY"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="PhylomeDB" id="B8M8P3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED20556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="37640" checksum="77AE9406E77C6308" modified="2009-03-03" version="1">MALDPSLYTVAWIAPIEIEARAALHSLDNYHEGQFPWSYGYDYLFHAGDINGHNVIIATLPGKQYGTGSAAALASQVKTFFPNIQFGLLVGVAAGLPNLAQSPPYDIRLGDVLVGFPDGESAGVIPYDLGKETKDGFQLLNCGYDLPKTESIVMSAIGNIKIQSPDDTDIVLEFYKDIQDKRHESGTFLDLGQDRDQLYTVDEDGVERVAERERRPDSKRVRVWYGPIGSGEKVVKTAEKRNELRDKYNVIGLEMEAAGVMTQIAVGVIRGVCDYGDEHKNKEWQPYAAAMAAAYAKAILYRILPGRALVHYQLQAMAMIGYIRGSQKPSKVSTLEVNYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8S2</accession>
    <name>B8M8S2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Disulfide isomerase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_037980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481019.1">
        <property type="nucleotide sequence ID" value="XM_002480974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8S2"/>
    <dbReference type="FunCoup" id="B8M8S2">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M8S2"/>
    <dbReference type="GeneID" id="8102174"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_037980"/>
    <dbReference type="eggNOG" id="KOG0191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021868_0_0_1"/>
    <dbReference type="InParanoid" id="B8M8S2"/>
    <dbReference type="OMA" id="IFVYFYD"/>
    <dbReference type="OrthoDB" id="72053at2759"/>
    <dbReference type="PhylomeDB" id="B8M8S2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877468" evidence="7">
        <location>
            <begin position="21"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="667"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="26"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="244"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED20585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="736" mass="82814" checksum="C80CB9C290544849" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8M911</accession>
    <name>B8M911_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_111450</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481298.1">
        <property type="nucleotide sequence ID" value="XM_002481253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M911"/>
    <dbReference type="STRING" id="441959.B8M911"/>
    <dbReference type="GeneID" id="8109825"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_111450"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8M911"/>
    <dbReference type="OMA" id="MSRMFIN"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="PhylomeDB" id="B8M911"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AUSG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED17306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="511" mass="58762" checksum="D4537919FC262DA0" modified="2009-03-03" version="1">MSFRLEVAISRCRNFEIGSFYVFCCVVFLFCYWWKSTKLENPSGLPVIGRRWYEIGYGKASERFRHDCLGLVRSCLEKYGDAFYLYTDSRYRLILSGKYVDMLRNEKRLDFITALADKLVNGVPGFEPMESMTSSKKIIHAVTKHSLNRNLGTFIEPLNEESNYALDQVWTDDPEFHEVMLKDSVWKIFGRIMSRTFINDRDFYRNPEWVNASSEYVELSALAGYELRAFPKWAKCWVAPFLPNCRKLQSLFKHINKLLEPLKEKLDQQPPGVDSKDPLSFLYQKTGGRLDELASMLIALCLVSYDGGGELFTHVLHSVFTNSQLVNDLRAEIVTVIGKEGFNKNTLQNLVLMDSVLKEVQRMHPESVLMMQRIALEEVVLPDGLIIPKGTALFVSACHIIDASVWPEGDKFDGYRFFNLRRKGKPSTSQVSYNFTSTSPDHFSFGHGSQACPGRFFASYMQKILLCNILMRYDVSVTIPDEGAWFQRGQTHVAHPGLKARVRRRKEEIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9U3</accession>
    <name>B8M9U3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA a64-2'-o-ribosylphosphate transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_118620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482087.1">
        <property type="nucleotide sequence ID" value="XM_002482042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9U3"/>
    <dbReference type="FunCoup" id="B8M9U3">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M9U3"/>
    <dbReference type="GeneID" id="8099785"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_118620"/>
    <dbReference type="eggNOG" id="KOG2634">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027654_1_1_1"/>
    <dbReference type="InParanoid" id="B8M9U3"/>
    <dbReference type="OMA" id="PVFWANQ"/>
    <dbReference type="OrthoDB" id="45256at2759"/>
    <dbReference type="PhylomeDB" id="B8M9U3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043399">
        <property type="term" value="F:tRNA adenosine(64)-2'-O-ribosylphosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019988">
        <property type="term" value="P:charged-tRNA amino acid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007306">
        <property type="entry name" value="Rit1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033421">
        <property type="entry name" value="Rit1_DUSP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033449">
        <property type="entry name" value="Rit1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811:SF0">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04179">
        <property type="entry name" value="Init_tRNA_PT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17184">
        <property type="entry name" value="Rit1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007747">
        <property type="entry name" value="Ribosyl_Ptfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rit1 N-terminal" evidence="2">
        <location>
            <begin position="32"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Rit1 DUSP-like" evidence="1">
        <location>
            <begin position="349"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED18095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="463" mass="51137" checksum="0BCE0F622FBA4109" modified="2009-03-03" version="1">MSSDGRTAYPVSLSEIEFPSAAVSVSQLLTSLRRSALSVTNRLRSIEADARFVSEAADHYGGLPLIANERCGSWYINPDQKAGSVYFKSTDGHTGVWEFSFRRLNLQVLEIARQNGGCIIVDSTRRGKLMPDALSKTVPIWSAVLNRALFPSEPAYHPVQFPPSFLGASEEAQIEKRIDGFVRTFKELKLDLDKLRKDLGYPIRLAWANQTYFYPTTLQKGEGYNLFVLCSASRRVHGAEASEGGYIQGAGDDSEKWSHGLTAPVFWANKDLLFKTDESQLPHVIHDLISRTDDNSGSGAGQNKKQGILIRPSSNLYISQSRPNSDIQGEEYDLVIACNDKPGLSSSKRLNLGCGSHKLGSRDLRTALEKVKVFAEKHLTSNPSQSLLVTCKTGKDLSVGTLLAIICLLYDDEGNCTGPQADTYIDKQYIRQRLTWIVTSNPDANPSRATLQSVNAFLLQRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MA10</accession>
    <name>B8MA10_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conserved leucine-rich repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_120830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
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        <property type="protein sequence ID" value="EED18339.1"/>
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    <dbReference type="Proteomes" id="UP000001745">
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    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
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</entry>
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            <taxon>Eurotiomycetidae</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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        <source>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
    <sequence length="204" mass="23082" checksum="5D24330739455761" modified="2009-03-03" version="1">MPEKVYVSYNQVHKLCQRSADKILEEFRPNLMIAIGGGGFIPARILRSFLKRPGEPNIPIQAIGLSLYENLGRDDPEEVPGTKVTRTQWLDLSSLEMANLIGKNILIVDEVDDTRTTLDYAVRELEKDVEQAQKSLGREGEKTTFSIFVLHNKDKSKKGKLPEDMIAAGRYHAAVTTGDVWICYPWEAKDIDEHDELAKKFPLI</sequence>
</entry>
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    <accession>B8MBQ2</accession>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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        </subcellularLocation>
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    </dbReference>
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        <location>
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            <end position="29"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </reaction>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
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    <sequence length="518" mass="57596" checksum="99D527B671114083" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MC41</accession>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <property type="protein sequence ID" value="EED18487.1"/>
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    <dbReference type="GeneID" id="8097688"/>
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    <dbReference type="InParanoid" id="B8MC41"/>
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    <dbReference type="PhylomeDB" id="B8MC41"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="InterPro" id="IPR024312">
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    </dbReference>
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        <property type="entry name" value="Fungal_TACC"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED18487.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8MC47</accession>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
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    </reference>
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    <dbReference type="PANTHER" id="PTHR39610">
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            <end position="68"/>
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    </feature>
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        <location>
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        <location>
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        <location>
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            <end position="34"/>
        </location>
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        <location>
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            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="298" mass="32004" checksum="4BC23C14A185DA8F" modified="2009-03-03" version="1">MAPPDLNSVPPSPRLGHTSQPDPEVPSTNRTSHTMGPPPMPVNTMSPTITTEPAGLGPGPLRHPRPMTAADLHLVLEKEQEAVVNRLTRELTLLRQQTASVASTASSTSTGLTDPTDTSVYPTSSRQHRSSSNLSSHIPPGSAALASSVSSIAPSRDTALPSSRPSGEFTRVGRSREPSVTSPRQPVSPYGDVGFQYSQSQGQQSHRSSVSHSHNAAYPPEARRSTSISSTAGSRFEEAAQQRAELEAVKRENEMLRRRVRELEQTLKVYRDPHVHSPEEPSTSTLATGMRDTTLAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCN9</accession>
    <name>B8MCN9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_126490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482933.1">
        <property type="nucleotide sequence ID" value="XM_002482888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCN9"/>
    <dbReference type="GeneID" id="8099076"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_126490"/>
    <dbReference type="eggNOG" id="KOG1121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077443_0_0_1"/>
    <dbReference type="InParanoid" id="B8MCN9"/>
    <dbReference type="OMA" id="SEPRVEC"/>
    <dbReference type="OrthoDB" id="4508978at2759"/>
    <dbReference type="PhylomeDB" id="B8MCN9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23272">
        <property type="entry name" value="BED FINGER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="161"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED18941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="272" mass="31377" checksum="162B265707923EA5" modified="2009-03-03" version="1">MLDQEEWRQIEYLLWITQPFFKFTTALSQTKDVIFHVIFSIYNKLFDHLEVSICRLQRKKVAWKKLMLSALHAAKEKLSVYYREIDKVYGDLFAIGTILAPQNKLQFFNNKDWGPELRLYKERLSATQGSPQIPSLGVQTSKIDALFAPDFNQLVSSDEATQYLESEMAPIAPRTFWKEHEHKFLALANMVHDILLIPATGAGIERLFNSTRDQALDEEKDAQQLQDTLEPISDNEDDGLEISIDQLATQQLSKRAQGTRRMSMVSNGEQEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDA9</accession>
    <name>B8MDA9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oligopeptide transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_114470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481626.1">
        <property type="nucleotide sequence ID" value="XM_002481581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MDA9"/>
    <dbReference type="GeneID" id="8109209"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_114470"/>
    <dbReference type="eggNOG" id="KOG1237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_327940_0_0_1"/>
    <dbReference type="InParanoid" id="B8MDA9"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="PhylomeDB" id="B8MDA9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED17634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="877" mass="96930" checksum="C1A16B4580C3E6FA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDF5</accession>
    <name>B8MDF5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation initiation factor eIF4E3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_117040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481910.1">
        <property type="nucleotide sequence ID" value="XM_002481865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MDF5"/>
    <dbReference type="STRING" id="441959.B8MDF5"/>
    <dbReference type="GeneID" id="8102096"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_117040"/>
    <dbReference type="eggNOG" id="KOG1669">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043552_0_0_1"/>
    <dbReference type="InParanoid" id="B8MDF5"/>
    <dbReference type="OMA" id="DNANLWT"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="PhylomeDB" id="B8MDF5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000015">
        <property type="entry name" value="Translation initiation factor eIF4E3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF18">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E HOMOLOGOUS PROTEIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED17918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="354" mass="38509" checksum="5D763939727DA8A0" modified="2009-03-03" version="1">MDQANLWTRRSNASKLSLSTASDKEGSSRPELPRTHSSKRFGPDSSHGRSNPFNAISPLSGGVSSPSAGASNAFGLGSGAFASFGSSTKTPKTPGSTFDLSSTTKDKRDTSEDTSSAAGNIKSKTSSSSLDTTSTTAIKEHPLKSTWIVWYRPPTPKYSDYEKSTVALASISSVESFWTIYSHLKRPSLLPTVSDYHIFKKGIRPVWEDEANKRGGKWIIRLKKGVADRYWEDLLLAIVGDQFAEAGDEVCGTVLSVRSGEDVLSVWTRIDGGRNIKIRETIKRVLALPADTNIVWKSHDDSIAQRSAIDQARQEKAAANSGHHHHGYHHGANERRRGGNNDESFGDRSKGMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDS1</accession>
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        <recommendedName>
            <fullName evidence="8">Hydantoinase/oxoprolinase</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">TSTA_120480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002482247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MDS1"/>
    <dbReference type="GeneID" id="8100032"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_120480"/>
    <dbReference type="eggNOG" id="ENOG502QQBE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007154_0_0_1"/>
    <dbReference type="InParanoid" id="B8MDS1"/>
    <dbReference type="OMA" id="AYPTMEH"/>
    <dbReference type="OrthoDB" id="5404895at2759"/>
    <dbReference type="PhylomeDB" id="B8MDS1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.390.10">
        <property type="entry name" value="CV3147-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1610.10">
        <property type="entry name" value="CV3147-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048350">
        <property type="entry name" value="S-Me-THD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024071">
        <property type="entry name" value="S-Me-THD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010318">
        <property type="entry name" value="S-Me-THD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027479">
        <property type="entry name" value="S-Me-THD_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF10">
        <property type="entry name" value="HYDANTOINASE_OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20906">
        <property type="entry name" value="S-Me-THD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06032">
        <property type="entry name" value="S-Me-THD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160991">
        <property type="entry name" value="CV3147-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="3">
        <location>
            <begin position="5"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="205"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="S-Me-THD N-terminal" evidence="4">
        <location>
            <begin position="615"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="S-Me-THD-like C-terminal" evidence="5">
        <location>
            <begin position="779"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED18300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1010" mass="107654" checksum="88C2A40EF1188E48" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEA2</accession>
    <name>B8MEA2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_016090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483763.1">
        <property type="nucleotide sequence ID" value="XM_002483718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEA2"/>
    <dbReference type="STRING" id="441959.B8MEA2"/>
    <dbReference type="GeneID" id="8106382"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_016090"/>
    <dbReference type="HOGENOM" id="CLU_391860_0_0_1"/>
    <dbReference type="InParanoid" id="B8MEA2"/>
    <dbReference type="OMA" id="RVHTSHA"/>
    <dbReference type="OrthoDB" id="4526749at2759"/>
    <dbReference type="PhylomeDB" id="B8MEA2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002875083" description="GPI anchored protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED16529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="596" mass="61806" checksum="5E3D997237C1CBD1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MED3</accession>
    <name>B8MED3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATPase inhibitor, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_016380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Inhibits the enzyme activity of ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ATPase inhibitor family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483794.1">
        <property type="nucleotide sequence ID" value="XM_002483749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MED3"/>
    <dbReference type="FunCoup" id="B8MED3">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MED3"/>
    <dbReference type="GeneID" id="8106411"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_016380"/>
    <dbReference type="eggNOG" id="ENOG502SCJG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145563_0_0_1"/>
    <dbReference type="InParanoid" id="B8MED3"/>
    <dbReference type="OMA" id="NQGGEHN"/>
    <dbReference type="OrthoDB" id="5532350at2759"/>
    <dbReference type="PhylomeDB" id="B8MED3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007648">
        <property type="entry name" value="ATPase_inhibitor_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04568">
        <property type="entry name" value="IATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED16560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="102" mass="11435" checksum="E15450814F02C9EF" modified="2009-03-03" version="1">MFRNAVARPVLRANQRLVAIRSFSVAPVRMGEGDLGAPKAGGSAAADSFTKREAAQENLYVKEKELQKLRELKHKLAEQRKHLDELDKHIDQLTKEQGGEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEN1</accession>
    <name>B8MEN1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_019750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484148.1">
        <property type="nucleotide sequence ID" value="XM_002484103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEN1"/>
    <dbReference type="GeneID" id="8104670"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_019750"/>
    <dbReference type="eggNOG" id="ENOG502SVBM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067893_1_0_1"/>
    <dbReference type="InParanoid" id="B8MEN1"/>
    <dbReference type="OrthoDB" id="4436005at2759"/>
    <dbReference type="PhylomeDB" id="B8MEN1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="47"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED16914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="200" mass="22050" checksum="AB44E28CBF4DAE0C" modified="2009-03-03" version="1" fragment="single">ADHESSPMFERRRAFGPPSCAPSQLTPKRPRISYSYRFFPPTGKSALIVNIYNAPAGSIRAGEVAKALTTLPEAYFPQATILAGDLNLLHNRWQPSLHRSPTPSAEPFINWLDLQGLVLISDIDCPTHERGNVLDLSFASSPLALAGAKTSIASHLDSTSDHQPLITTVPWDQRYKETAQKLRFDTLDHTCFLSLLASNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B8MF15</accession>
    <name>B8MF15_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_009090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483018.1">
        <property type="nucleotide sequence ID" value="XM_002482973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MF15"/>
    <dbReference type="GeneID" id="8100770"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_009090"/>
    <dbReference type="HOGENOM" id="CLU_1405644_0_0_1"/>
    <dbReference type="InParanoid" id="B8MF15"/>
    <dbReference type="OrthoDB" id="4357294at2759"/>
    <dbReference type="PhylomeDB" id="B8MF15"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED15784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="194" mass="21218" checksum="A36DFE47D5ED500B" modified="2009-03-03" version="1" fragment="single">QAVIACVLHKAYYGAETWWLGRTCPGPRQTSNQVGEHLEKLTKAILVGARAVLPPSLHLSAYGALILITHFEDAQNRLLEIADKPADLPAINPLQYAPWHPRESRAPMGRTKEQAAADFTFLCSSLSYGHGKEVFDAEVEAALAGAQAAIICLNNLEVATRLLSPSTGSSQEVFESFYTLAATWPLRERLPHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>B8MG33</accession>
    <name>B8MG33_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_010180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483134.1">
        <property type="nucleotide sequence ID" value="XM_002483089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MG33"/>
    <dbReference type="GeneID" id="8102814"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_010180"/>
    <dbReference type="HOGENOM" id="CLU_2777648_0_0_1"/>
    <dbReference type="InParanoid" id="B8MG33"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED15900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="69" mass="7701" checksum="CD4036C18F92DA8E" modified="2009-03-03" version="1">MAIEDDPGTIRLEAVMWLSAGDHILWMGSPVCNRHETAVARVSQVPTPMPSWFEDSNVQTTRYLTLDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MG61</accession>
    <name>B8MG61_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_010460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483162.1">
        <property type="nucleotide sequence ID" value="XM_002483117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MG61"/>
    <dbReference type="STRING" id="441959.B8MG61"/>
    <dbReference type="GeneID" id="8105685"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_010460"/>
    <dbReference type="eggNOG" id="ENOG502QU1Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015493_3_1_1"/>
    <dbReference type="InParanoid" id="B8MG61"/>
    <dbReference type="OMA" id="TWFLYHE"/>
    <dbReference type="OrthoDB" id="5333823at2759"/>
    <dbReference type="PhylomeDB" id="B8MG61"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED15928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="515" mass="58397" checksum="24E304521E2FA6F3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8MG79</accession>
    <name>B8MG79_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Translation machinery-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_010620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 5">Interacts with the 40S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The SUI1 domain may be involved in RNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DENR family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483180.1">
        <property type="nucleotide sequence ID" value="XM_002483135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MG79"/>
    <dbReference type="FunCoup" id="B8MG79">
        <property type="interactions" value="1200"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MG79"/>
    <dbReference type="GeneID" id="8109835"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_010620"/>
    <dbReference type="eggNOG" id="KOG3239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073511_0_1_1"/>
    <dbReference type="InParanoid" id="B8MG79"/>
    <dbReference type="OMA" id="EVFEIDM"/>
    <dbReference type="OrthoDB" id="277199at2759"/>
    <dbReference type="PhylomeDB" id="B8MG79"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11607">
        <property type="entry name" value="DENR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046447">
        <property type="entry name" value="DENR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005873">
        <property type="entry name" value="DENR_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048517">
        <property type="entry name" value="DENR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01159">
        <property type="entry name" value="DRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21023">
        <property type="entry name" value="DENR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="SUI1" evidence="7">
        <location>
            <begin position="100"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED15946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="192" mass="21284" checksum="174C263BEB6FE4FB" modified="2009-03-03" version="1">MAEADQPVESRARHIVYCGVCTLPPEYCEFGGTSKKCEEWLEKTYPDLHQQLYSEEAINANLSTLSITAREKAAKDAAKKEAKALQAETRDAERKASSKIQIKRVERNKRKFVTVVIGLEAFGLDLKKVAKELGKKFATGSSVTKSPAGTEEITVQGDVSDDLFEWLIDVHGDKVPEDNVELIEDKKKKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGE1</accession>
    <name>B8MGE1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED8</name>
        <name evidence="11" type="ORF">TSTA_013610</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483494.1">
        <property type="nucleotide sequence ID" value="XM_002483449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGE1"/>
    <dbReference type="FunCoup" id="B8MGE1">
        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MGE1"/>
    <dbReference type="GeneID" id="8099161"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_013610"/>
    <dbReference type="eggNOG" id="ENOG502S8U1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074399_1_0_1"/>
    <dbReference type="InParanoid" id="B8MGE1"/>
    <dbReference type="OMA" id="WAPIEAN"/>
    <dbReference type="OrthoDB" id="5329317at2759"/>
    <dbReference type="PhylomeDB" id="B8MGE1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019364">
        <property type="entry name" value="Mediatior_Med8_fun/met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074:SF9">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10232">
        <property type="entry name" value="Med8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="172"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED16260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="252" mass="27687" checksum="36069841FC78E62C" modified="2009-03-03" version="1">MTAINESQVKVLEQTRQRLLHLTHSLDSLTGSLHQSDPLPSWSSLQSQASIISNNLINICSQLAEHQELLSSLVAYPAPSFPTNTQQGVLEQLLRTKLDPRVEDWVTRGRIAGTEASLKENGGLSDADLAELWSWAPVEANQEARRRNWGGNYTLEEKELGIQNVVTGLKRALPDDDDEEDEDEDEEFEDVNEDGGENMEIVGVHTRPGAGGVEFDIAGGRDHVPSASASPALPLDEVFRYMMTGMRPKSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGK4</accession>
    <name>B8MGK4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD-repeat protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_018260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483989.1">
        <property type="nucleotide sequence ID" value="XM_002483944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGK4"/>
    <dbReference type="STRING" id="441959.B8MGK4"/>
    <dbReference type="GeneID" id="8100936"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_018260"/>
    <dbReference type="eggNOG" id="KOG4155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1807516_0_0_1"/>
    <dbReference type="InParanoid" id="B8MGK4"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="PhylomeDB" id="B8MGK4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="12"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED16755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="143" mass="15578" checksum="FAF9809414D029E8" modified="2009-03-03" version="1">MEEGRSACLGILEGDNRWVNSVTYFHDSKHLASASDDGTVKIWDASTGQCLQTFKGHRNTVYSLAFSHDSKHLASASDDRTSAQSPTLIIQSTLSQLQTIALSRYGIPAVANAYRRSRVKAIQSTRSPIPIARLASGDRTAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGQ3</accession>
    <name>B8MGQ3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CSN12 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_018710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN12 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484038.1">
        <property type="nucleotide sequence ID" value="XM_002483993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGQ3"/>
    <dbReference type="FunCoup" id="B8MGQ3">
        <property type="interactions" value="886"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MGQ3"/>
    <dbReference type="GeneID" id="8100981"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_018710"/>
    <dbReference type="eggNOG" id="KOG2688">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031567_1_0_1"/>
    <dbReference type="InParanoid" id="B8MGQ3"/>
    <dbReference type="OMA" id="INRMFTL"/>
    <dbReference type="OrthoDB" id="10252687at2759"/>
    <dbReference type="PhylomeDB" id="B8MGQ3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000366">
        <property type="entry name" value="COP9 signalosome complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF0">
        <property type="entry name" value="PCI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="249"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00073854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED16804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="456" mass="51247" checksum="99F0E3D6C458EE40" modified="2009-03-03" version="1">MASVFDDFKAAHTLQSGPILAAALTPAATPEDPHRLLNFVRVTNSANSEGDIRHHLLYDRHTGVKLSKQQGNAWVSVVNAFWVTAVELVKIEEYSPRGSWLKVFEAWKEFVNQLIRGYSNNHFPSWTIPCLYMAGKYLRAFAIKADASDASQSAGGYGNGFQDDVVSAEKNANLEDAARTINRMFTLCLGDRAPIEESRKWGIYETTNLLFKTYFKLNQVGLSKSVLRALDASSADIPQPFQFPKSHIVTFNYYVGLINFLEENYKEAEESLTQAWLMCKKDAWKNKELILTYLIPCHLVTTHRLPSKQLLAPFPRLERLLRPLCDCIRQGNLVGFDAAMSAGADDFVKRRIYLPLERGRDLALRNLFRKVFIAGGFEPATASDSVPIRRTRIPLTEFAAALRIGNKSDDKARIDMDEVECLLANMIYKNMMKGYISRERATVVLSKSGAFPGTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHG0</accession>
    <name>B8MHG0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_021960</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484373.1">
        <property type="nucleotide sequence ID" value="XM_002484328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHG0"/>
    <dbReference type="STRING" id="441959.B8MHG0"/>
    <dbReference type="GeneID" id="8098462"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_021960"/>
    <dbReference type="eggNOG" id="ENOG502QSWP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025694_1_1_1"/>
    <dbReference type="InParanoid" id="B8MHG0"/>
    <dbReference type="OMA" id="CGFYWSG"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="PhylomeDB" id="B8MHG0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF37">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877591" description="Mannan endo-1,6-alpha-mannosidase" evidence="13">
        <location>
            <begin position="24"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="402"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="416"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED17139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="473" mass="51434" checksum="E7AC70FC4139DE2D" modified="2009-03-03" version="1">MRSFITFSILLGQLLLTMPFATALTVNANDPNSLKSAASTAAASAVNYYNNRESKLIPGKFDGTWWEGGAFFTFLINYWHWTGDDQYNNLVAEGLSWQGGEDNDFFPSNYSSYLGNDDQEFWALAALTAIEQKFPDNPGHASWLSLAQGAFNDFVARWEVDKASCGGGLRWQLYPTLAGYDSKNAISNGAFFQIAARLARYTNNDTYATWAETVWDWSSTVPLFDNSTWKIYDMTRISENCKDQDVMQWSYNYGSYVTGAAYMYNYTNGGTKWKEGVDGLLNTTWNTFFPTEYGGNILSEVACDPILTCNRDQVCFKGLMANWLSTIALIVPYTYSTILPKLQGSAVGAGAQCSGPNSACGMQWFSQKYDGTSAIEQEMSAMSIFSNALVGFSAPTANSGSSYTAPEAPAPVTADTGGNSTSNPSGGQSSTGYQPPKAMKITGGDRAGAAILTLVFATAWIGMMVWLVIGGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIE4</accession>
    <name>B8MIE4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="10">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_041070</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 54 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="10"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484581.1">
        <property type="nucleotide sequence ID" value="XM_002484536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIE4"/>
    <dbReference type="STRING" id="441959.B8MIE4"/>
    <dbReference type="GeneID" id="8099915"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_041070"/>
    <dbReference type="eggNOG" id="ENOG502QS3Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029332_3_0_1"/>
    <dbReference type="InParanoid" id="B8MIE4"/>
    <dbReference type="OMA" id="THYNTGC"/>
    <dbReference type="OrthoDB" id="157622at2759"/>
    <dbReference type="PhylomeDB" id="B8MIE4"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23399">
        <property type="entry name" value="beta-trefoil_ABD_ABFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000131">
        <property type="entry name" value="Probable alpha-L-arabinofuranosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000059">
        <property type="entry name" value="Probable alpha-L-arabinofuranosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015289">
        <property type="entry name" value="A-L-arabinofuranosidase_B_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038964">
        <property type="entry name" value="ABFB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007934">
        <property type="entry name" value="AbfB_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036195">
        <property type="entry name" value="AbfB_ABD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39447">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39447:SF2">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05270">
        <property type="entry name" value="AbfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09206">
        <property type="entry name" value="ArabFuran-catal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110221">
        <property type="entry name" value="AbfB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027147021" description="Alpha-L-arabinofuranosidase" evidence="10">
        <location>
            <begin position="27"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-arabinofuranosidase B catalytic" evidence="12">
        <location>
            <begin position="28"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-arabinofuranosidase B arabinose-binding" evidence="11">
        <location>
            <begin position="354"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="89"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="177"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="403"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR638964-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR638964-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED14628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="500" mass="52122" checksum="A5639526447D5E23" modified="2009-03-03" version="1">MFFSRPVRDRFSSVLALCLYVTGSIAGPCDIYSSGGTPCVAAHSTTRALYDSYTGALYQVSRGSDGATTDISPLSAGGVANSGAQDSFCANTTCLITIIYDQSGHGNDLTQAPPGGAASGPDANGYDYLASAVGAPVTLNGEKAYGYRNNNVKGTATGDEPEGLYAVFDGTHYNTGCCFDYGNAETNSHDTGNGHMEAIYFGTGDGSGRGTGSGSGPWIMADLENGLFSGYDPINNAADPTITSRFVTAIVKGESNQWAIRGGDATSGSLSTYYSGIRPANGYNPMQKEGAIILGIGGDNSNNAQGTFYEGVMTSGYPSDDIENQVQANIVAAGYATTPLTSGPGLTVGENISMRATTACCTTRYLAHTDSTVNTQVVTSSSGTSLKQQASWTVRTGLGNTACFSFESVDSPGSFIRHSNYELKVNANDGSKIFSEDATFCPQAGLNGQGNSFRSWSYPTRYWRHYNAVGYIASNGGPHDFDSAVSFNDDVSFVVSGGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8MII7</accession>
    <name>B8MII7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_045410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485032.1">
        <property type="nucleotide sequence ID" value="XM_002484987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MII7"/>
    <dbReference type="GeneID" id="8099505"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_045410"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_30_0_1"/>
    <dbReference type="InParanoid" id="B8MII7"/>
    <dbReference type="OMA" id="ENSEFNW"/>
    <dbReference type="OrthoDB" id="4842715at2759"/>
    <dbReference type="PhylomeDB" id="B8MII7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="8">
        <location>
            <begin position="186"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED15079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="550" mass="61414" checksum="9175514AF438FD78" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIR3</accession>
    <name>B8MIR3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uracil permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_050130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485528.1">
        <property type="nucleotide sequence ID" value="XM_002485483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIR3"/>
    <dbReference type="GeneID" id="8108777"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_050130"/>
    <dbReference type="eggNOG" id="KOG2466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021555_3_0_1"/>
    <dbReference type="InParanoid" id="B8MIR3"/>
    <dbReference type="OMA" id="YNRFVWG"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="PhylomeDB" id="B8MIR3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF15">
        <property type="entry name" value="NICOTINAMIDE RIBOSIDE TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="402"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="414"/>
            <end position="434"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="465"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="512"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="532"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED15575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="597" mass="66323" checksum="E3EE44358596A3B3" modified="2009-03-03" version="1"> </sequence>
</entry>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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</entry>
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    <accession>B8MIZ7</accession>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15659.1"/>
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    <dbReference type="STRING" id="441959.B8MIZ7"/>
    <dbReference type="GeneID" id="8109139"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
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    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="38672" checksum="EAC92C8B35282785" modified="2009-03-03" version="1">MSTSMKSLMILFLAAMATARPLSRREVPQEHSHQKFIATVAASLAANNPDNIGDPVFGLLGNKAAAQGAGSIKDLDCLQQAIADQAFTNAKAAGDVNGMTAALVYRTLERNTGSVGLASVKCTSVKAKNPEIAALQQHQDPASSGAAATNKQIALELAKQIASIGGDPSTAIQSGTFAPGQIGDTTGKGKTCDDQNDPTGCIFTQNLLVPDVTQDEINAAVGSAGGSAAAAPSASAAVAASSSAGIAAAPTATAASSSNQASTGTCSSSTGASDSATGANAATNNNASTSTTPSTSSLDLGSCKNASPFIKFGAGFDGRKENSFEPADKATFNHGSALNIGVVANFICDRLNDPCKASQTTLDTCKSAASAASKLSGQAAADAFNKALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJ44</accession>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15706.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJ44"/>
    <dbReference type="STRING" id="441959.B8MJ44"/>
    <dbReference type="GeneID" id="8106344"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_051420"/>
    <dbReference type="HOGENOM" id="CLU_2428563_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJ44"/>
    <dbReference type="OrthoDB" id="4890185at2759"/>
    <dbReference type="PhylomeDB" id="B8MJ44"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED15706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="91" mass="10564" checksum="04408BBBF7BF1782" modified="2009-03-03" version="1">MHMRAVRVAWRVTLQRFYDPQEGPTVRVMARSTCQSQQATPKKAYCNPSKLSEAEVDYIIEWITSLKHMRCMPYYKVIEELNLSVGKNALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJG1</accession>
    <name>B8MJG1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-galactose dehydrogenase (L-GalDH), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_046150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:dehydro-D-arabinono-1,4-lactone biosynthetic process"/>
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        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
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    </dbReference>
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            <begin position="16"/>
            <end position="324"/>
        </location>
    </feature>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED15161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="485" mass="53690" checksum="973EC8C988902C7D" modified="2009-03-03" version="1">MGKMTTRPPPSKHLTPLILGTATFNTQYNADPFSLPSTAIVHRALSSGIRAFDTSPYYGPSEEILGQALATEQVSQQFPRSTYQLLTKVGRVAESSFDYSPAWVRYSIRRSLKRLRTDYLDVVYCHDVEFVSAPEVLEAVKELRRIREEDGSILYVGISGYPVETLCELAELVLQETGEPLDVVMSYANYNLQNMRLATEGLARLRAAGVDVVPNASILGMGLLRGQPVFDWHPAPKGLRDAIHKASELVSQKLMKLETVATRFGLESWLREGSPVGVLGHPLEAADASTSIFSKGQRLGVTVVGVSKVKEVDELVASYREVLDGGAFLSGETGRASQDIELYNMVRAALGDWVGYAWPSPGEGYLNTLPEEHYQLLREQETTTTTATGSKGEIAMYIHDIFTDSYKYSNSNTFLTPISELGDDGLGEVIQCSHSYSLRENNSHLGMKDLIRWWGARSAYPYLVNPRLSARPLLDLAKSLQVVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJQ4</accession>
    <name>B8MJQ4_TALSN</name>
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        <recommendedName>
            <fullName evidence="3">Peptidase M61 catalytic domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_051900</name>
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    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="441959.B8MJQ4"/>
    <dbReference type="GeneID" id="8103411"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_051900"/>
    <dbReference type="eggNOG" id="ENOG502RUBF">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_024392_1_0_1"/>
    <dbReference type="InParanoid" id="B8MJQ4"/>
    <dbReference type="OMA" id="HNWPRLG"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="PhylomeDB" id="B8MJQ4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED15753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="59955" checksum="BE05DB4743DA5B7F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJS7</accession>
    <name>B8MJS7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_042190</name>
        <name evidence="4" type="ORF">TSTA_106650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484697.1">
        <property type="nucleotide sequence ID" value="XM_002484652.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486693.1">
        <property type="nucleotide sequence ID" value="XM_002486648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJS7"/>
    <dbReference type="STRING" id="441959.B8MJS7"/>
    <dbReference type="GeneID" id="8102996"/>
    <dbReference type="GeneID" id="8103565"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_042190"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_106650"/>
    <dbReference type="eggNOG" id="ENOG502S2ZX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_4_0_1"/>
    <dbReference type="InParanoid" id="B8MJS7"/>
    <dbReference type="OrthoDB" id="4457643at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
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        <location>
            <begin position="6"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED14455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED14744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="489" mass="55972" checksum="CCF8B2A982B3D3D9" modified="2009-03-03" version="1">MAYRAETRANGHKLTQSEEESLVRWILDLDKRGLPPRHSLVRDMANCLLSQRGNQHVGENWVYNLVKRRPEIESKFSRKYNYERAKCEDPKIIQEYFDRVREVILEYGILPEDIYNFDETGFAMGLCATTKVITGSDRYARPKLLQPGDREWVTAIEAVNSIGWALPSYIIFKAKKYTRLGWFEDLPDDWKINISDNGWTTDNIGLEWLKTHFIPLIDGRTLGKYRMLILDGHGSHLTAEFDRTCTENNIIPPLDVGCFAVLKRHYGQLVEQRMRLGFNHIDKLDFLTAFPKARTMAYKAQTVRNSFTATGLVPFNPDRVYQQLTVRLKTPTPPPSRSSDTQSSCLQTPQNACQFKRQMTTTKKRISRHTRSSSEAIGEVFTRASKAYEMSINKLTIAQKELHDLRAAHEKEKQKRQKSKKQISHDHGITREEAQALVQGQIEASQAVSTAPAEPELPVSHPPVRRHFRCSGCGIEGHKITGCPNRTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJT5</accession>
    <name>B8MJT5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_042270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484705.1">
        <property type="nucleotide sequence ID" value="XM_002484660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJT5"/>
    <dbReference type="STRING" id="441959.B8MJT5"/>
    <dbReference type="GeneID" id="8103004"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_042270"/>
    <dbReference type="HOGENOM" id="CLU_013929_14_2_1"/>
    <dbReference type="InParanoid" id="B8MJT5"/>
    <dbReference type="OrthoDB" id="4324149at2759"/>
    <dbReference type="PhylomeDB" id="B8MJT5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="38"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED14752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="423" mass="49008" checksum="B469C744CC8FB253" modified="2009-03-03" version="1">MWGVLGVHSKLRSKLSRGYGVSHKKLSRRWNGPPSRSTRSPTNRLLSLDQEKAHILWIEYLDNIGAPPTNEQIEESANYLLAKDFNDPGEPPRAGKMWIYNFLNRLPENLSSRESITVVEAINAEGKIIPPLLIPKGENHMEEWYRHIQDDEWLIAPAKNGFITDEIAFEWLQHFQHYSKPDWSSEWRLLLMDSHATHLTIQFVQYCEIYHIRPFRFPHSMHFLQPLDGMPFQQYKHVHGRVVNKVARLGGFDFNKNDFFEELRDIRIKTFTTRTIRHGWKERGIWPYDPKFILDKMPQPDEAFEKLAADGDTLKIYSEPDNTIPSSPTTKSISPPSSVAKLRRYINKIEKSVDGIKDILDSASPGLSRRIKVINQGSLTLAELGELHRESSMKVRDTAKRKQQQTTKRQVKAMGALYVKDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJT7</accession>
    <name>B8MJT7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_042290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484707.1">
        <property type="nucleotide sequence ID" value="XM_002484662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJT7"/>
    <dbReference type="GeneID" id="8103006"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_042290"/>
    <dbReference type="eggNOG" id="ENOG502RQI6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_26_1_1"/>
    <dbReference type="InParanoid" id="B8MJT7"/>
    <dbReference type="OrthoDB" id="5413694at2759"/>
    <dbReference type="PhylomeDB" id="B8MJT7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED14754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="178" mass="19745" checksum="EBE287C630204F7C" modified="2009-03-03" version="1">MGRTKEQAAADFMAFQHTIPSLDIFLRSSLSYGHRKEVFDTEAEAALAGAQAAIAYPTAQFATNLWIYLDNLEVATRLLSPSTGSSQEVFESFRTLAAAWPLRERLPHTKSGSIQIRWVPRHTKIPKNEAADLAAKEGAVSIPPSPYKSSYALLKRYAKTQSLSATQTRWQTVAPQTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>B8MK98</accession>
    <name>B8MK98_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein YTM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">YTM1</name>
        <name evidence="10" type="ORF">TSTA_047040</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485206.1">
        <property type="nucleotide sequence ID" value="XM_002485161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MK98"/>
    <dbReference type="FunCoup" id="B8MK98">
        <property type="interactions" value="893"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MK98"/>
    <dbReference type="GeneID" id="8098497"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_047040"/>
    <dbReference type="eggNOG" id="KOG0313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_0_1"/>
    <dbReference type="InParanoid" id="B8MK98"/>
    <dbReference type="OMA" id="DHKYVEF"/>
    <dbReference type="OrthoDB" id="10251381at2759"/>
    <dbReference type="PhylomeDB" id="B8MK98"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110136">
        <property type="term" value="P:protein-RNA complex remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000593">
        <property type="entry name" value="Ribosome biogenesis protein ytm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03029">
        <property type="entry name" value="WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028599">
        <property type="entry name" value="WDR12/Ytm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="9">
        <location>
            <begin position="16"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="164"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="213"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="287"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="374"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED15253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="487" mass="52425" checksum="62DF11292F730EE7" modified="2009-03-03" version="1">MDVEASSLSQANQRQVRLHLTTRDGDIALPESTGPILVPTGLRRYALSTLVNNLLGNDKPIPLEFLVNGTYLRTSIDEYLTANGISAETTLEVEYVRALIPPLHIASFLHDDWVSSVDVLSATSVTGESVAAGQERILSGSYDGLLRMWNMSSQTIAVSPDASEGGHTASIKAAKFISPTQLASAGLDRTVRVWKYAEEEDGSMTRITPQLELYGHKSGINSLSVHAPSNRMLSASSDHSVGFWSTRKSDAPTALAELLPSNTARSSKRRKLNSSVSTPQRGPLVLLSSHTSPVSAAIFDAKDSTVGYSASWDHSVRTWDLVTSALVDTRSTSHPLLSLEHLPELHLLAAGTSARHITLIDPRASATSVSVMTLRGHTNAVVTLARDPNSTYGLISGSHDGTCRIWDVRSTKTDKEGVVGKDIYSISRKSLEESGREGSKRIGGDGIKVFGVCWDRSVGIVSAGEDKRLQINRGEGVLQKDSSKRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKF3</accession>
    <name>B8MKF3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_047540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002485216.1"/>
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    <dbReference type="AlphaFoldDB" id="B8MKF3"/>
    <dbReference type="STRING" id="441959.B8MKF3"/>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_047540"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032825_0_0_1"/>
    <dbReference type="InParanoid" id="B8MKF3"/>
    <dbReference type="OrthoDB" id="10016252at2759"/>
    <dbReference type="PhylomeDB" id="B8MKF3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="46"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED15308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="683" mass="76539" checksum="739BC70FBD738470" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKP6</accession>
    <name>B8MKP6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SPX domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_043660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484848.1">
        <property type="nucleotide sequence ID" value="XM_002484803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKP6"/>
    <dbReference type="FunCoup" id="B8MKP6">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MKP6"/>
    <dbReference type="GeneID" id="8097874"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_043660"/>
    <dbReference type="eggNOG" id="KOG1161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009308_2_0_1"/>
    <dbReference type="InParanoid" id="B8MKP6"/>
    <dbReference type="OMA" id="SFKFWVH"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="PhylomeDB" id="B8MKP6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.100.30:FF:000002">
        <property type="entry name" value="Vacuolar transporter chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF2">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 3 COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="698"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="741"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="9">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="541"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="337"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="562"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="589"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED14895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="796" mass="90255" checksum="DEB42CD90206E93F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKQ9</accession>
    <name>B8MKQ9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial import receptor subunit tom22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_043780</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom22 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484861.1">
        <property type="nucleotide sequence ID" value="XM_002484816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKQ9"/>
    <dbReference type="FunCoup" id="B8MKQ9">
        <property type="interactions" value="264"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MKQ9"/>
    <dbReference type="GeneID" id="8097886"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_043780"/>
    <dbReference type="eggNOG" id="KOG4111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094333_1_0_1"/>
    <dbReference type="InParanoid" id="B8MKQ9"/>
    <dbReference type="OMA" id="LVWIVTT"/>
    <dbReference type="OrthoDB" id="10016939at2759"/>
    <dbReference type="PhylomeDB" id="B8MKQ9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22884">
        <property type="entry name" value="TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005683">
        <property type="entry name" value="Tom22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04281">
        <property type="entry name" value="Tom22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED14908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="161" mass="17732" checksum="0E4D71E33B033BD9" modified="2009-03-03" version="1">MVKLTEVEDEHFTTEKPIPTSKDTLLMSDNEEDDDFTDTESEISVDSTYDLTNETLYDRLIALKDIIPPQSRRRIISTVNSITDATKSTFSFSGKALWVISTSAFLLGVPWALAFAEEEQYVQMEREQGMMRGANEMLTPGTNAAAAALGAAGTEQSKPAL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2023-11-08" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKZ7</accession>
    <name>TSTL_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS-type transporter phiL</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phomoidride biosynthesis cluster protein L</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tstL</name>
        <name type="ORF">TSTA_048530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1997" name="J. Antibiot." volume="50" first="1" last="7">
            <title>CP-225,917 and CP-263,114, novel Ras farnesylation inhibitors from an unidentified fungus. I. Taxonomy, fermentation, isolation, and biochemical properties.</title>
            <authorList>
                <person name="Dabrah T.T."/>
                <person name="Harwood H.J. Jr."/>
                <person name="Huang L.H."/>
                <person name="Jankovich N.D."/>
                <person name="Kaneko T."/>
                <person name="Li J.C."/>
                <person name="Lindsey S."/>
                <person name="Moshier P.M."/>
                <person name="Subashi T.A."/>
                <person name="Therrien M."/>
                <person name="Watts P.C."/>
            </authorList>
            <dbReference type="PubMed" id="9066758"/>
            <dbReference type="DOI" id="10.7164/antibiotics.50.1"/>
        </citation>
        <scope>BIOTECHNOLOGY</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="Org. Lett." volume="17" first="5658" last="5661">
            <title>Biosynthetic study on antihypercholesterolemic agent phomoidride: general biogenesis of fungal dimeric anhydrides.</title>
            <authorList>
                <person name="Fujii R."/>
                <person name="Matsu Y."/>
                <person name="Minami A."/>
                <person name="Nagamine S."/>
                <person name="Takeuchi I."/>
                <person name="Gomi K."/>
                <person name="Oikawa H."/>
            </authorList>
            <dbReference type="PubMed" id="26558485"/>
            <dbReference type="DOI" id="10.1021/acs.orglett.5b02934"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2022" name="J. Am. Chem. Soc." volume="144" first="20998" last="21004">
            <title>Elucidation of late-stage biosynthesis of phomoidride: proposal of cyclization mechanism affording characteristic nine-membered ring of fungal dimeric anhydride.</title>
            <authorList>
                <person name="Yamamoto S."/>
                <person name="Matsuyama T."/>
                <person name="Ozaki T."/>
                <person name="Takino J."/>
                <person name="Sato H."/>
                <person name="Uchiyama M."/>
                <person name="Minami A."/>
                <person name="Oikawa H."/>
            </authorList>
            <dbReference type="PubMed" id="36374185"/>
            <dbReference type="DOI" id="10.1021/jacs.2c09308"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4">MFS-type transporter; part of the gene cluster that mediates the biosynthesis of the antihypercholesterolemic agents phomoidrides which are dimeric anhydrides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="biotechnology">
        <text evidence="5">Phomoidrides A and B (also known as CP-225,917 and CP-263,114) are potent inhibitors of Ras farnesyltransferase and squalene synthase (PubMed:9066758). CP-225,917 and CP-263,114 inhibit Ras farnesyl transferase from rat brain with IC(50) values of 6 uM and 20 uoM, respectively (PubMed:9066758). CP-225,917 inhibits squalene synthase with an IC(50) value of 43 uM and CP-263,114 with an IC(50) of 160 uM (PubMed:9066758).</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. CAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485366.1">
        <property type="nucleotide sequence ID" value="XM_002485321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKZ7"/>
    <dbReference type="STRING" id="441959.B8MKZ7"/>
    <dbReference type="GeneID" id="8107035"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_048530"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_8_4_1"/>
    <dbReference type="InParanoid" id="B8MKZ7"/>
    <dbReference type="OMA" id="RRPAYAF"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="PhylomeDB" id="B8MKZ7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF144">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000458955" description="MFS-type transporter phiL">
        <location>
            <begin position="1"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="26558485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="36374185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="9066758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="26558485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED15413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="489" mass="53280" checksum="264F4B9E5A1A9778" modified="2009-03-03" version="1">MTASEQTALLGSPRKPAYTIFSNSQKLLIILTATLASVFSPLSANIYYPALKSIQKELNVSEEILNMTITSYMIFQGLSPTFIGSLSDTIGRRPVYIICFLIYIAANVGLTFQTTFIGLLLLRCLQSSGSSSTVNLAYGVTADVVTSAERGRYVGLASVGPIIGPTLGPVLGGIISQYYGWRFIFVVLTGMALIMLIFIIVFLPETCRNIVGNGSLEPLSVWNKPLSSFLCKKKENEDLDETLEAQQAIEAARKKGGKPKPWKSLTLLFTYPTGCVILFNGFTFATYYAVTTSLTWCFSSTYHFNEVEIGLSYIPIGVGSMIAAFTNGFLLDWNYRRAVKKVLGRPLARGEHFDHDTGVALGFHIERTRLQIVIPAVVLAMLAMVAYGWSVYLVLTPAVPLVLLFLFGWLGTAAYSGMNVLIVDLNLKSPATATAANNLIRCMLGALGAMVIMPIINAVGMGWTFIMISGVWIVLSPLIILVAWSKSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8ML95</accession>
    <name>B8ML95_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kelch repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_044760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484963.1">
        <property type="nucleotide sequence ID" value="XM_002484918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ML95"/>
    <dbReference type="STRING" id="441959.B8ML95"/>
    <dbReference type="GeneID" id="8104152"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_044760"/>
    <dbReference type="eggNOG" id="ENOG502SIX7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012508_1_2_1"/>
    <dbReference type="InParanoid" id="B8ML95"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="PhylomeDB" id="B8ML95"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228:SF2">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_4G14350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="552"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED15010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="658" mass="71999" checksum="8E592CC092BD50DC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLP6</accession>
    <name>B8MLP6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="2 6">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_101490</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="2 6"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486147.1">
        <property type="nucleotide sequence ID" value="XM_002486102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLP6"/>
    <dbReference type="FunCoup" id="B8MLP6">
        <property type="interactions" value="116"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MLP6"/>
    <dbReference type="GeneID" id="8101837"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_101490"/>
    <dbReference type="eggNOG" id="ENOG502QPT5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031468_10_3_1"/>
    <dbReference type="InParanoid" id="B8MLP6"/>
    <dbReference type="OMA" id="KFLVNCC"/>
    <dbReference type="OrthoDB" id="73846at2759"/>
    <dbReference type="PhylomeDB" id="B8MLP6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="8">
        <location>
            <begin position="57"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="9">
        <location>
            <begin position="200"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED13909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="341" mass="37837" checksum="F9A357ED28AD1803" modified="2009-03-03" version="1">MKTNGLDDNKTGFDVNVLDNKTWHSIPYWKERATTETSDEEEEYPLRLEQDLNDAPSSEREELDTSYTDDEKIECLIVTTKATHAVQAVSSVSHRLTPDSTILFLQNGMGIIDEVNEAVFPDPSIRPHYLQGVISHGVKNLRPFHIEYTGVGTTIMGPLPSSTDANIQTKDWAPSIKYLLRTLTLTAPLVAVAESPIGVLQYQLEKLAMNCVINPFTVLLDAKNAEISTVICALPELDGVPGVKARFSPERLKTLAVRLANATAANTSSMLQDVQVMKRTEIEYINGYIVRRGDELGIRCALNYMIMQLVLGKNHILRLRDAGAVPLSPLEAEEMEGEEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MME1</accession>
    <name>B8MME1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Penicillin-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_099470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485933.1">
        <property type="nucleotide sequence ID" value="XM_002485888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MME1"/>
    <dbReference type="STRING" id="441959.B8MME1"/>
    <dbReference type="GeneID" id="8104025"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_099470"/>
    <dbReference type="eggNOG" id="ENOG502S4SE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_14_1_1"/>
    <dbReference type="InParanoid" id="B8MME1"/>
    <dbReference type="OMA" id="YRDPWYG"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="PhylomeDB" id="B8MME1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021860">
        <property type="entry name" value="Peptidase_S12_Pab87-rel_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF15">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11954">
        <property type="entry name" value="DUF3471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="17"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S12 Pab87-related C-terminal" evidence="3">
        <location>
            <begin position="410"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED13695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="516" mass="58171" checksum="1514D1D626C3039C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNT1</accession>
    <name>B8MNT1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_103890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486408.1">
        <property type="nucleotide sequence ID" value="XM_002486363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNT1"/>
    <dbReference type="STRING" id="441959.B8MNT1"/>
    <dbReference type="GeneID" id="8103092"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_103890"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_23_8_1"/>
    <dbReference type="InParanoid" id="B8MNT1"/>
    <dbReference type="OMA" id="WEHTINM"/>
    <dbReference type="OrthoDB" id="4226558at2759"/>
    <dbReference type="PhylomeDB" id="B8MNT1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="268"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="492" mass="54932" checksum="BEB9FB6FAF70E5D9" modified="2009-03-03" version="1">MDKLSHLPKKDKLGLGIYQAIRRIVAALLGDKGALQAAKDTWNELAKTQPRLTDSTSTEEVEREAEWIERTLTEVLNKYCKLIRVCARSKRWWNSEIEAERSAYSKARKAYQAGEISEEEHREARKSFYSLVSRTKRECWEGFLQGTSEGSLPDQKRCWTALRYTKLQTQGTTPALTDEASGEVIAATFSEKEEVFRHRAFPQAPNSNIESQLPEPGSAHKLVNEEAVKNALFSQGLEKAPGTDLLNFRAIRLLWNLDLERVVSLVKQCLRLGIHPRIWKIAKGVLLRKNGKTNYTLASAYRVISLLKCLGKVTEKLVAELITNFAEAQDLFHDGQFGGRRQRSAIDAVACLVEEIHQAWANGKLAAALFMDIKGAFDHVVLARLIEVLREASVDGDLIRWVVSFLSDRRVTPVIDGHIGKEASISSGLPQGSPVSPILFVLYVHGLSRAIERSVPEIRCLSFVDDQGLITAASSVKEACRTLEKAAEVAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNT6</accession>
    <name>B8MNT6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_103940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486413.1">
        <property type="nucleotide sequence ID" value="XM_002486368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNT6"/>
    <dbReference type="GeneID" id="8103166"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_103940"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045444_0_0_1"/>
    <dbReference type="InParanoid" id="B8MNT6"/>
    <dbReference type="OrthoDB" id="4226988at2759"/>
    <dbReference type="PhylomeDB" id="B8MNT6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="366" mass="39767" checksum="C487E0AF8A4C9B93" modified="2009-03-03" version="1">MRAASAPAEDSLVMGLIEDLNGHLQEAVHQLSAELTTARNVINTQQGLITTLNARLESLETYVNALQSRQILPLDPFTATREVAAHGPPPRAASTGGLASTPIQLDAAPESRAINSTAPQPQPQYQNPTKATKQAVQPPEGPKKYKKQALAPSKALSTTNLKPVSTRSKEERRLIFRRRYPKDAPTALKADILLALNRALAKAGFPDFVRAVDSGYAASGALTVLLERGTRSSTLVPVYNDTLLAAVRQTDPAVISVEISEQWHRVKVQAVPVDRYMYNDQGLALAQEEIELGTPYRLKREPTWLKRAKTIQASNQRFATIVITHLIGSQILRVSAPDAAESATPASWLVVAGLLDARSAQVTMRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8MP98</accession>
    <name>B8MP98_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_105480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486575.1">
        <property type="nucleotide sequence ID" value="XM_002486530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MP98"/>
    <dbReference type="STRING" id="441959.B8MP98"/>
    <dbReference type="GeneID" id="8100407"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_105480"/>
    <dbReference type="eggNOG" id="ENOG502QTD3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070319_0_0_1"/>
    <dbReference type="InParanoid" id="B8MP98"/>
    <dbReference type="OMA" id="YRMTVIS"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="PhylomeDB" id="B8MP98"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03141">
        <property type="entry name" value="GATase1_Hsp31_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF22">
        <property type="entry name" value="DJ-1_PFPI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="3">
        <location>
            <begin position="100"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED14337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="247" mass="26986" checksum="5A4659FB66B61AFE" modified="2009-03-03" version="1">MAPKKVLIVLSDAHSFPLKKPASSSNDKDQIVQQPSGFFLMELAKPLAQLLESGAPNPLQTPTVETLLAFAGNFYERRHENELIDRMRRENGFDSPRPFKSISDEELDSFAGVFIPGGHAPLQDLGDDPELGRILKHFHNKTKPTAAICHGPYAFLSTKATSPGEFAYKGYKLTSWSDAEERMMETMLGGEIEKVESSLKDSGAEMVAGAREKAGYITVDKEVVSGGNPLAADALGKQFLKMLSEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPA3</accession>
    <name>B8MPA3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-galactosidase</fullName>
            <ecNumber evidence="6">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_105530</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="6"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486580.1">
        <property type="nucleotide sequence ID" value="XM_002486535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPA3"/>
    <dbReference type="STRING" id="441959.B8MPA3"/>
    <dbReference type="GeneID" id="8100412"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_105530"/>
    <dbReference type="eggNOG" id="KOG0496">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007853_7_2_1"/>
    <dbReference type="InParanoid" id="B8MPA3"/>
    <dbReference type="OMA" id="FWNIHEQ"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="PhylomeDB" id="B8MPA3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026283">
        <property type="entry name" value="B-gal_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048912">
        <property type="entry name" value="BetaGal1-like_ABD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048913">
        <property type="entry name" value="BetaGal_gal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21317">
        <property type="entry name" value="BetaGal_ABD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21467">
        <property type="entry name" value="BetaGal_gal-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006336">
        <property type="entry name" value="B-gal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877617" description="Beta-galactosidase" evidence="9">
        <location>
            <begin position="17"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="10">
        <location>
            <begin position="16"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED14342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="663" mass="71693" checksum="77A2A75D0D67A4CC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQB2</accession>
    <name>B8MQB2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short chain dehydrogenase/reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_058030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487425.1">
        <property type="nucleotide sequence ID" value="XM_002487380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQB2"/>
    <dbReference type="GeneID" id="8108939"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_058030"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_0_1"/>
    <dbReference type="InParanoid" id="B8MQB2"/>
    <dbReference type="OMA" id="ESPMYKI"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="PhylomeDB" id="B8MQB2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF32">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED13314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="248" mass="26806" checksum="CAD87AD15DCD3F4C" modified="2009-03-03" version="1">MATASKRLVLITGASGGIGFELAAQLLAKGTYYVLLGARSVEKGNAALEQLRSHNLPDSVELLLLDVTKDNTIEEAAVKVRKEFGKLDILINNAAVAPMEGGTLREYMRIAFDTNATGPLIVGNAFAPLLKESKDSPRIVNITSGAGSISSRLNKDSPTYRLQGHQYRASKSALNMITACQYVEYESDGIKVLLYDPGHTVSNLGPYNKAEFGARAPVESVIPLIDVIEGKRDNEAPKLLHNTGTYDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQL4</accession>
    <name>B8MQL4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S28e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_059240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487548.1">
        <property type="nucleotide sequence ID" value="XM_002487503.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487549.1">
        <property type="nucleotide sequence ID" value="XM_002487504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQL4"/>
    <dbReference type="FunCoup" id="B8MQL4">
        <property type="interactions" value="905"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MQL4"/>
    <dbReference type="GeneID" id="8107394"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_059240"/>
    <dbReference type="eggNOG" id="KOG3502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178987_1_0_1"/>
    <dbReference type="InParanoid" id="B8MQL4"/>
    <dbReference type="OMA" id="NTGMHGE"/>
    <dbReference type="OrthoDB" id="10258930at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000025">
        <property type="entry name" value="40S ribosomal protein S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00292">
        <property type="entry name" value="Ribosomal_eS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028626">
        <property type="entry name" value="Ribosomal_eS28_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00961">
        <property type="entry name" value="RIBOSOMAL_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED13437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="68" mass="7737" checksum="0C8E071DA44E08BF" modified="2009-03-03" version="1">MDSAKVPVKLVKVTRVLGRTGSRGGVTQVRVEFMDDQTRSIIRNVKGPVREDDILCLLESEREARRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8MR34</accession>
    <name>B8MR34_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_054410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487040.1">
        <property type="nucleotide sequence ID" value="XM_002486995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MR34"/>
    <dbReference type="FunCoup" id="B8MR34">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MR34"/>
    <dbReference type="GeneID" id="8107435"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_054410"/>
    <dbReference type="eggNOG" id="KOG4347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003538_1_0_1"/>
    <dbReference type="InParanoid" id="B8MR34"/>
    <dbReference type="OMA" id="IYMSETQ"/>
    <dbReference type="OrthoDB" id="17687at2759"/>
    <dbReference type="PhylomeDB" id="B8MR34"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000021">
        <property type="entry name" value="GTPase activating protein (Gyp2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000015">
        <property type="entry name" value="GTPase activating protein (Gyp2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="291"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="880"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="885"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1082"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1105"/>
            <end position="1120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED12929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1141" mass="127264" checksum="4E74181DD7ED60E2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRB6</accession>
    <name>B8MRB6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_055170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487122.1">
        <property type="nucleotide sequence ID" value="XM_002487077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRB6"/>
    <dbReference type="STRING" id="441959.B8MRB6"/>
    <dbReference type="GeneID" id="8102210"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_055170"/>
    <dbReference type="eggNOG" id="KOG4173">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055660_1_0_1"/>
    <dbReference type="InParanoid" id="B8MRB6"/>
    <dbReference type="OMA" id="YEEYEIH"/>
    <dbReference type="OrthoDB" id="18440at2759"/>
    <dbReference type="PhylomeDB" id="B8MRB6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039258">
        <property type="entry name" value="ZNF511"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21354">
        <property type="entry name" value="ZINC FINGER PROTEIN 511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21354:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED13011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="249" mass="28410" checksum="2E39041E684CA784" modified="2009-03-03" version="1">MAKRSRTNDQTSDASPLHLTEPEQSTSPPTKITVPSPDNSSESQPQQQCLMKCSLPPHKDTLTFSSYDDYEAHYLKFHVNRCSECGKNFPTQHILNIHIEENHDPLILARRDRGEKTFSCFVEGCERKCSTPQKRRRHLIDKHMFPRNYNFFIVNDGIDKQNSLLHTSQNHGHHRRLSLPPQSPLEGRLRNRKTSVSLAPVNDGEGLDESSKEQGMEVGDDEIDVLASSLSALRFVPTSVIKRLELERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRH9</accession>
    <name>B8MRH9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 alkane hydroxylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_056150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487227.1">
        <property type="nucleotide sequence ID" value="XM_002487182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRH9"/>
    <dbReference type="STRING" id="441959.B8MRH9"/>
    <dbReference type="GeneID" id="8100680"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_056150"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_27_0_1"/>
    <dbReference type="InParanoid" id="B8MRH9"/>
    <dbReference type="OMA" id="FRIAPWH"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="PhylomeDB" id="B8MRH9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF18">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED13116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="521" mass="59062" checksum="F7B3DE45B740F4C7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MS62</accession>
    <name>B8MS62_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_001880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LovG family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487774.1">
        <property type="nucleotide sequence ID" value="XM_002487729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MS62"/>
    <dbReference type="GeneID" id="8098682"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_001880"/>
    <dbReference type="eggNOG" id="KOG2551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051938_0_2_1"/>
    <dbReference type="InParanoid" id="B8MS62"/>
    <dbReference type="OMA" id="PRMLCLH"/>
    <dbReference type="OrthoDB" id="4212945at2759"/>
    <dbReference type="PhylomeDB" id="B8MS62"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000296">
        <property type="entry name" value="Probable esterase afoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF3">
        <property type="entry name" value="ESTERASE DBAE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED12120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="274" mass="30597" checksum="62E28B1213EBCBB9" modified="2009-03-03" version="1">MTIKISTTEEVDLTLHLPRILCLHGGGTNARIFHMQCRGLERALKSTFRLVYAEAPFPAQPGSDVTSVYKDHGPFKAWLRCTAADPERSAQDITEQINLSIAKAMYSDNLRGATGEWVALLGFSQGAKVAASILYAQQTLQQQLGENAAIWPHFRFAVLMAGRGPLVWMLPNMSNSPTSIPMGLVDASCPSMMSSEPELPKDREHMLRIPTLHVHGLRDPGLALHRRLYHGYCRQDSASLVEWEGEHRVPIKSKDVRAVVDQIYTWARELKSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSB3</accession>
    <name>B8MSB3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_000430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED11966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487620.1">
        <property type="nucleotide sequence ID" value="XM_002487575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSB3"/>
    <dbReference type="STRING" id="441959.B8MSB3"/>
    <dbReference type="GeneID" id="8108666"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_000430"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001650_6_0_1"/>
    <dbReference type="InParanoid" id="B8MSB3"/>
    <dbReference type="OMA" id="KTEMIRI"/>
    <dbReference type="OrthoDB" id="4356562at2759"/>
    <dbReference type="PhylomeDB" id="B8MSB3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF438">
        <property type="entry name" value="REVERSE TRANSCRIPTASE TY1_COPIA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="26074" checksum="DEF47518F864374C" modified="2009-03-03" version="1">MASKFGINAMNNVKTPISGNIEASTEQATNEEIHVYQKLVGSALYVTVMTRVDVAKAVNKLAKHTKNPSKAHFQQIRRVIQYLYNTRSLVIEYSPLENVNMDAFICALDTSSGDNPDRTSSKGYLVQLYGGPINWRATKQRLVTISTTEAELRAATEAAKRLQFHTNLKHVDIYHHWLQQEVSKKRLRIEWVDTKRMVADGLTKVLHGQQFLDWRKHQGLVDIADLVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MT46</accession>
    <name>B8MT46_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PWI domain mRNA processing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_003120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487903.1">
        <property type="nucleotide sequence ID" value="XM_002487858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MT46"/>
    <dbReference type="STRING" id="441959.B8MT46"/>
    <dbReference type="GeneID" id="8098008"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_003120"/>
    <dbReference type="eggNOG" id="KOG2146">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8MT46"/>
    <dbReference type="OMA" id="KICMDRV"/>
    <dbReference type="OrthoDB" id="163257at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052225">
        <property type="entry name" value="Ser/Arg_repetitive_matrix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148">
        <property type="entry name" value="SERINE/ARGININE REGULATED NUCLEAR MATRIX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148:SF0">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWI" evidence="3">
        <location>
            <begin position="12"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="323"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="423"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED12249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="484" mass="56483" checksum="215F1EFD887766D0" modified="2009-03-03" version="1">MTSNVDAKLLKQTKFPPEFSKKVDMTKVNIEVMKKWIAGKLSELLGNEDDVVIELCFGLLESSRFPDIKALQIQLTGFLDKDTPKFCQELWNLCLSAQSSPQGVPKELLEAKKQELKQEKLDAERAAEEARRRKEQERERERELETIRQKERSDRNRGFRDNRGGRGFDRRGSRSPRRYSPDRRGAPSRREFDSYVPRGNRRSRQSPRSYARSVSRSPSLSRSPPRRSYRSDERNRRRPRSASRSPSPDGRGYKRNRRRSPPYGDERDRSVARNESSSRSPSPRRTRRRYSSVSSRNPSRSPTPPRTRRGRDRSPSRTRVRRNTSSVSVSRSRSRQPSYKNRRRRSSSRRSEDRSVRGSKTDIAAKSRSFRDDRRLSRSTSSRRDRSVSRSPSPRGDRKRRRSLERYAPAARRRHNDSPGSPHAERKQSSADVEDIKMQDGSEAKERTSNKLRLSANELRERVLKERLKAMRRKASNEKTEDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTG7</accession>
    <name>B8MTG7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain type dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_003570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487953.1">
        <property type="nucleotide sequence ID" value="XM_002487908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTG7"/>
    <dbReference type="STRING" id="441959.B8MTG7"/>
    <dbReference type="GeneID" id="8098053"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_003570"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="InParanoid" id="B8MTG7"/>
    <dbReference type="OMA" id="CHPGNAI"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="PhylomeDB" id="B8MTG7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED12299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="399" mass="43675" checksum="E0512EB9E2531019" modified="2009-03-03" version="1">MSLNVSLATPFISTLQLDTKKQATAVLIAHDLQLETYIHILNEIMKEEEFLNSIEDLTGRVAIVTGGAKGIGLETSVYLALKGATVYIAARGSKGTYAGIEDVRNRLKSVVGDESLGSKIKYHNLDLGSMQNAWNSAREFARIESQLDILVCNAGVSMTTMQELSPDGFDTMFAVNHLGHFAFTTGLLDLIKQTSKTTQDSRIVFTNSNAYKLASPLDYEKLTTLIPNDGQTFKDASNAFKRYADSKLAALYGVLELTHRLRQQFGLTNIYINSCHPGNAIGTTLGAGHQKAVHPILEKVVRAGLQVTIGNSTADSAKTQVYLAGSRYIKDHDTYGAFWEPSFSWIAKAYKGCAGEEYTELARDEVERKKLWDVTVEAFKKAVGEDEIGSVDIVKGLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTJ7</accession>
    <name>B8MTJ7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_004490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488056.1">
        <property type="nucleotide sequence ID" value="XM_002488011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTJ7"/>
    <dbReference type="STRING" id="441959.B8MTJ7"/>
    <dbReference type="GeneID" id="8104433"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_004490"/>
    <dbReference type="eggNOG" id="ENOG502S0AG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033002_1_0_1"/>
    <dbReference type="InParanoid" id="B8MTJ7"/>
    <dbReference type="OMA" id="CGIRKIW"/>
    <dbReference type="OrthoDB" id="552755at2759"/>
    <dbReference type="PhylomeDB" id="B8MTJ7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037647">
        <property type="entry name" value="HIRIP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15410">
        <property type="entry name" value="HIRA-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15410:SF2">
        <property type="entry name" value="HIRA-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="336"/>
        </location>
    </feature>
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        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
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        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="336" mass="37970" checksum="7DD5ADCEAACF61CB" modified="2009-03-03" version="1">MPRRPIIEESSDGEANSSSNSIPPDDRLEEALRDTVANIFRTGKLEELTVKRIRLATESALGLDEGFFKTRGDWKVRSERIIKEEAERQEEAREHEETHKSPAPSPEPPKSKMKKAVKRESEENTSAKKKRRKVSSEVESRETTAQPVEDEEVEGKEAKSASPQPPSEEAAAERGEQSESEMSVLLDEEPPKKQRPKKAATAPKARNPKTTSKPTTDSDPDQAEIKRLQGWLIRCGIRKMWARELAPYDTPKAKIKRLKKMLEEAGMKGRYSLEKARQIREERELQADLEAVKEGASRWGTGRGQDESGSEGRPRRRLMKGRQSLAFLSDDGEETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTT1</accession>
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            <fullName evidence="2">MULE transposase domain-containing protein</fullName>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
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    </organism>
    <reference evidence="4" key="1">
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_002488220.1">
        <property type="nucleotide sequence ID" value="XM_002488175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTT1"/>
    <dbReference type="STRING" id="441959.B8MTT1"/>
    <dbReference type="GeneID" id="8105569"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_005960"/>
    <dbReference type="eggNOG" id="ENOG502RUBW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013727_5_1_1"/>
    <dbReference type="InParanoid" id="B8MTT1"/>
    <dbReference type="OMA" id="QEESYKW"/>
    <dbReference type="OrthoDB" id="4368270at2759"/>
    <dbReference type="PhylomeDB" id="B8MTT1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="2">
        <location>
            <begin position="220"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED12566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="568" mass="65526" checksum="2AB2621239D9E10E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MVC0</accession>
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        <submittedName>
            <fullName evidence="4">Reverse transcriptase, putative</fullName>
        </submittedName>
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        <name evidence="4" type="ORF">TSTA_008720</name>
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    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <lineage>
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    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
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        <property type="protein sequence ID" value="EED11576.1"/>
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    </dbReference>
    <dbReference type="STRING" id="441959.B8MVC0"/>
    <dbReference type="GeneID" id="8103260"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_008720"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_23_3_1"/>
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    <dbReference type="OMA" id="NERTEVC"/>
    <dbReference type="OrthoDB" id="4368687at2759"/>
    <dbReference type="PhylomeDB" id="B8MVC0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1162"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="3">
        <location>
            <begin position="1649"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="690"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED11576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1977" mass="222081" checksum="F0F31EF3DD127AB5" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8MVC7</accession>
    <name>B8MVC7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_007770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962663">
        <property type="protein sequence ID" value="EED11487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488803.1">
        <property type="nucleotide sequence ID" value="XM_002488758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MVC7"/>
    <dbReference type="GeneID" id="8103451"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_007770"/>
    <dbReference type="eggNOG" id="ENOG502T1HS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2135219_0_0_1"/>
    <dbReference type="InParanoid" id="B8MVC7"/>
    <dbReference type="OMA" id="KAERRCT"/>
    <dbReference type="OrthoDB" id="2976890at2759"/>
    <dbReference type="PhylomeDB" id="B8MVC7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="13308" checksum="39A736ECF812A56C" modified="2009-03-03" version="1">MLPDGEKIIVRIRAFLKKAYPAQKKPISTALSANYKSLEYRFLEPFQPTQYNISESDIDQYFDTPTISTGFDPNQSQTEFIRNWWKANKLEFPCMAKDSWDFIKAERRCTLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8LT47</accession>
    <name>B8LT47_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_069730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340942.1">
        <property type="nucleotide sequence ID" value="XM_002340901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LT47"/>
    <dbReference type="GeneID" id="8102638"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_069730"/>
    <dbReference type="eggNOG" id="ENOG502RPHS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103057_0_0_1"/>
    <dbReference type="InParanoid" id="B8LT47"/>
    <dbReference type="OrthoDB" id="5279542at2759"/>
    <dbReference type="PhylomeDB" id="B8LT47"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="181" mass="19983" checksum="9BA79F8769DCBE98" modified="2009-03-03" version="1">MNGTISRFRFQCMNIRDRLVHTPWLFIKTVIRGITAALAVISLSFFAAAIPCWNHNLEHIHGPEKGDWQDGIPIAPLALAFLYNTCTTIYAVKKGKGVPYHILEVLIDFLILSALAAALVFAIWGGVFNVWSTASTMMGPSGMMMVMCDESSNAFSRECFPELYPLGLIEIAAIGFAVPVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTB1</accession>
    <name>B8LTB1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fucose-specific lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_059830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the fungal fucose-specific lectin family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002339872.1">
        <property type="nucleotide sequence ID" value="XM_002339831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTB1"/>
    <dbReference type="GeneID" id="8108609"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_059830"/>
    <dbReference type="HOGENOM" id="CLU_2442365_0_0_1"/>
    <dbReference type="InParanoid" id="B8LTB1"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="PhylomeDB" id="B8LTB1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012475">
        <property type="entry name" value="Fungal_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07938">
        <property type="entry name" value="Fungal_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED22485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="90" mass="10444" checksum="0975E086DC446351" modified="2009-03-03" version="1">MAYVASLDAIEFFRDGKRHIRVYYQFSGVDKVIRESCYHQEHGWFVKGDGVVTDLAKNNTPITATRWTEDGGSTQIRVFFLDEQNNIRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTF3</accession>
    <name>B8LTF3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CLP1</name>
        <name evidence="14" type="ORF">TSTA_064920</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Polynucleotide 5'-kinase involved in rRNA processing.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Clp1 family. Clp1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340418.1">
        <property type="nucleotide sequence ID" value="XM_002340377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTF3"/>
    <dbReference type="FunCoup" id="B8LTF3">
        <property type="interactions" value="800"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LTF3"/>
    <dbReference type="GeneID" id="8110182"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_064920"/>
    <dbReference type="eggNOG" id="KOG2749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018195_3_1_1"/>
    <dbReference type="InParanoid" id="B8LTF3"/>
    <dbReference type="OMA" id="DITGWWP"/>
    <dbReference type="OrthoDB" id="258143at2759"/>
    <dbReference type="PhylomeDB" id="B8LTF3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002095">
        <property type="entry name" value="mRNA cleavage and polyadenylation factor clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1030:FF:000001">
        <property type="entry name" value="Protein CLP1 homolog 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03035">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028606">
        <property type="entry name" value="Clp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010655">
        <property type="entry name" value="Clp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06807">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 N-terminal" evidence="12">
        <location>
            <begin position="27"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="13">
        <location>
            <begin position="161"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 C-terminal" evidence="11">
        <location>
            <begin position="407"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="433"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="442"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="164"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED23031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="556" mass="58938" checksum="F0C431389E01E015" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUI7</accession>
    <name>B8LUI7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_071570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341147.1">
        <property type="nucleotide sequence ID" value="XM_002341106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUI7"/>
    <dbReference type="STRING" id="441959.B8LUI7"/>
    <dbReference type="GeneID" id="8105591"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_071570"/>
    <dbReference type="eggNOG" id="ENOG502SD2Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074375_0_0_1"/>
    <dbReference type="InParanoid" id="B8LUI7"/>
    <dbReference type="OMA" id="VYMPSMA"/>
    <dbReference type="OrthoDB" id="3993201at2759"/>
    <dbReference type="PhylomeDB" id="B8LUI7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="1">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="261" mass="28360" checksum="DF2D4C99765767FC" modified="2009-03-03" version="1">MTAPRSTSLRALRALSQHQTPATTLYCRRRLHITGAFSAQPVEGTDKAAAYAARTLADLKNECHRRGLRTGGSKSELVDRLSNNDVLYTRAFNIAKTRINGSVFGGPAETRSFNTSRASKAVNDSSTLDFVYMPNIASLEDESNPAQRIPIIGNLNFDFSTSPDQHHSEYPPMKPQIHAIGESGPDLSASPMSEVVDNHAVDIDPFKLTETVGKSRAGENEMRERRLASQGGEKGVIGELFSGMIDDIWGKGSAASSSKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>B8LV66</accession>
    <name>B8LV66_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_065700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340503.1">
        <property type="nucleotide sequence ID" value="XM_002340462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LV66"/>
    <dbReference type="GeneID" id="8106015"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_065700"/>
    <dbReference type="eggNOG" id="ENOG502RQQ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023880_4_0_1"/>
    <dbReference type="InParanoid" id="B8LV66"/>
    <dbReference type="OMA" id="ACNVRKK"/>
    <dbReference type="OrthoDB" id="4226267at2759"/>
    <dbReference type="PhylomeDB" id="B8LV66"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED23116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="503" mass="55617" checksum="A4C5CCF64DBE6B8F" modified="2009-03-03" version="1">MERAQFVCTTCSARKKGCDKALPACGFCAKRGLSCKYDGPARKERSFRPYNPGKYFVASGTLNAPISPISIVNSASSPDTPSVTASISQSIHESLYQQVRDVLNLANLTAEDISKRYFDSFHRLYPIISPELFYQAQSKYAHGGSISPSTDYSILVLAMFLAITLPGHHRPTNLSLSDQEQLYVKVKSLIAQIQTAISPSFALVQVMFIVTIWEYTRARPEAAYSSINACSSLARILGVGDELLEKSAPYQSNIITNLVEIVKRNVAWAVIMLERIILVELNPKAIRPLTGYPNIDCQLPLDLLPSDSSLSQSIDYQSSISATLSCLETGNVSWFGRQAQAIFLLDNVLEVVRTASKTGITQGILQGAVELDGMIRNFLAMLLEESRQKKTSLCSSVAFSIRALFLLHWSIFDALPTSGNESNYQARNLSWTAINSACNMTIDAITHAQQEPDSPVPICSFYILQEAIRYLSEHQKVAGDEATVSDKDMLIHADKEYRSTYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8LV76</accession>
    <name>B8LV76_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_065790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340513.1">
        <property type="nucleotide sequence ID" value="XM_002340472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LV76"/>
    <dbReference type="STRING" id="441959.B8LV76"/>
    <dbReference type="GeneID" id="8106177"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_065790"/>
    <dbReference type="HOGENOM" id="CLU_1327158_0_0_1"/>
    <dbReference type="InParanoid" id="B8LV76"/>
    <dbReference type="OMA" id="NADHYPL"/>
    <dbReference type="OrthoDB" id="4486039at2759"/>
    <dbReference type="PhylomeDB" id="B8LV76"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="24026" checksum="03970D40139367B9" modified="2009-03-03" version="1">MKLYETLNDNEKEYDTLLVNYNKLAEEDNALKDDYAVLQIEFSDLQKELEELKKARDDLIADHDLVEILGAALVNRPSKSTKLPKGAKLSDGVDPIFDSWLIDMRHSLNSNEDHYDTPETRMAFVKRICEGKAARYLLPQMREDSLNPFVNVEDMFEHLKTIFHDVNRVVKAKNQLFTLQMKKDTHFQDFLAEFTELAQDSEINVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B8LV90</accession>
    <name>B8LV90_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_065930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340527.1">
        <property type="nucleotide sequence ID" value="XM_002340486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LV90"/>
    <dbReference type="STRING" id="441959.B8LV90"/>
    <dbReference type="GeneID" id="8102373"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_065930"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1035039_0_0_1"/>
    <dbReference type="InParanoid" id="B8LV90"/>
    <dbReference type="OrthoDB" id="3786303at2759"/>
    <dbReference type="PhylomeDB" id="B8LV90"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED23140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="269" mass="29997" checksum="292BB2A62D2DC3D0" modified="2009-03-03" version="1">MAIKAVNDTVGPDGIVLTILVFGAYPRITTDSPPSANGPIITETLNLVPESEVKVWCEGDGWSGPYKVISVNGHDVTVDLGNGAVAFRATLVQQYLRDSKNESDRLIRLPLSPPQEDLNCQDGRSQVNFDQTPRTRARVRLQDHPTNPNHYVETRGVHALQTPEMPALPRRRGQPRGSKNKLKAYAEVFISKKERDDLELAIKLRREGKIATNGAPFELSGKTEINSLIVNRTFKILHCADMDLRGIRIFNSHLVNEIKGKNKIPYEKS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-03" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVD6</accession>
    <name>UTP25_TALSN</name>
    <protein>
        <recommendedName>
            <fullName>U3 small nucleolar RNA-associated protein 25</fullName>
            <shortName>U3 snoRNA-associated protein 25</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>U three protein 25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">utp25</name>
        <name type="ORF">TSTA_073440</name>
    </gene>
    <organism>
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP25 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341342.1">
        <property type="nucleotide sequence ID" value="XM_002341301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVD6"/>
    <dbReference type="FunCoup" id="B8LVD6">
        <property type="interactions" value="1242"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LVD6"/>
    <dbReference type="GeneID" id="8103959"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_073440"/>
    <dbReference type="eggNOG" id="KOG2340">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018705_0_1_1"/>
    <dbReference type="InParanoid" id="B8LVD6"/>
    <dbReference type="OMA" id="QDRGDTF"/>
    <dbReference type="OrthoDB" id="10264378at2759"/>
    <dbReference type="PhylomeDB" id="B8LVD6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002356">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010678">
        <property type="entry name" value="UTP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053939">
        <property type="entry name" value="UTP25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053940">
        <property type="entry name" value="UTP25_NTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933">
        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06862">
        <property type="entry name" value="Utp25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22916">
        <property type="entry name" value="UTP25_NTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000408141" description="U3 small nucleolar RNA-associated protein 25">
        <location>
            <begin position="1"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="729" mass="83055" checksum="4947C3D33268AD9F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVW0</accession>
    <name>B8LVW0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_076930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341713.1">
        <property type="nucleotide sequence ID" value="XM_002341672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVW0"/>
    <dbReference type="GeneID" id="8101965"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_076930"/>
    <dbReference type="HOGENOM" id="CLU_2224952_0_0_1"/>
    <dbReference type="InParanoid" id="B8LVW0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED24326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="106" mass="11624" checksum="D384B01234F0D5B2" modified="2009-03-03" version="1">MLDIVACRWDQQKRQSGAAEAPIVFIYGNLGTTVCELTYFASELLDTAQSISHRQVCQHGIRDAGHISALQCMIKEDVAFGFCTCTEDHGDINSLRSAFAAENPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>B8LW13</accession>
    <name>B8LW13_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_077420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341766.1">
        <property type="nucleotide sequence ID" value="XM_002341725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LW13"/>
    <dbReference type="GeneID" id="8103952"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_077420"/>
    <dbReference type="HOGENOM" id="CLU_2086394_0_0_1"/>
    <dbReference type="InParanoid" id="B8LW13"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED24379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="117" mass="13030" checksum="A98E9F2FCF5EB0C2" modified="2009-03-03" version="1">MNRSRLDVCVIGVKLKGGGRATFGNSVWTHNIFATAFRDLCALDSFSTAGILAFAASIAERYTERRLAFAFQLDGSAFIGYSERKWLERALLMPIDSTPTLTVPNAVLLYRRIDTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8LW17</accession>
    <name>B8LW17_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C6 transcription factor AlcR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_077450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341770.1">
        <property type="nucleotide sequence ID" value="XM_002341729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LW17"/>
    <dbReference type="GeneID" id="8104701"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_077450"/>
    <dbReference type="eggNOG" id="ENOG502RN0U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_417476_0_0_1"/>
    <dbReference type="InParanoid" id="B8LW17"/>
    <dbReference type="OMA" id="RVYRYWN"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="PhylomeDB" id="B8LW17"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED24383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="657" mass="73922" checksum="941BF0C4A40426B2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>B8LX16</accession>
    <name>B8LX16_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_061540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340053.1">
        <property type="nucleotide sequence ID" value="XM_002340012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LX16"/>
    <dbReference type="GeneID" id="8103876"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_061540"/>
    <dbReference type="HOGENOM" id="CLU_2544149_0_0_1"/>
    <dbReference type="InParanoid" id="B8LX16"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED22666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="83" mass="9614" checksum="2766F6FC77BC5BD0" modified="2009-03-03" version="1">MSTGLLLNEIMDLKNYTVTERPEICFIHNSQRSNSPSDLFKVAEMEKRSLTGIPKIDLEIQAFRKLEKRKIKVIDNPDPNPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B8LX55</accession>
    <name>B8LX55_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_061930</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340092.1">
        <property type="nucleotide sequence ID" value="XM_002340051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LX55"/>
    <dbReference type="STRING" id="441959.B8LX55"/>
    <dbReference type="GeneID" id="8105618"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_061930"/>
    <dbReference type="eggNOG" id="KOG0615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_311042_0_0_1"/>
    <dbReference type="InParanoid" id="B8LX55"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="PhylomeDB" id="B8LX55"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="11">
        <location>
            <begin position="91"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="235"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="567"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="868"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="889"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED22705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="945" mass="106022" checksum="35538DC251867AD1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8LX79</accession>
    <name>B8LX79_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_062170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340116.1">
        <property type="nucleotide sequence ID" value="XM_002340075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LX79"/>
    <dbReference type="GeneID" id="8103967"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_062170"/>
    <dbReference type="HOGENOM" id="CLU_787954_0_0_1"/>
    <dbReference type="InParanoid" id="B8LX79"/>
    <dbReference type="OrthoDB" id="4226417at2759"/>
    <dbReference type="PhylomeDB" id="B8LX79"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="40228" checksum="44C769CA0EFB26E2" modified="2009-03-03" version="1">MSETRRRSRFQHLVFNNATDNTRDPGALVDEEAPKTTGKISLPQHGRLSSSGKPRRVVKTETTTPKKVSFTQPGILSSSGKPKGVFKTKTSKLTRTNTKHRIESPWDNYVFVDEIVKDDDTVIKVRKSVSGQMFAFRTFPNDEKFEVIEQQFKLLDHHNVLSAQEFFRHGQRAFIRSSVMDISFDRIVMCRQYPSSRVLASMIGQTMDGLHYLVSNGVICDSLTCSKLMANKDGCVKIVAFSDAKIQEDIRASTTNLIMRLTSVMVLLMQKFDNEAGETSIQDNARWSPQDEACRFLQDLHSTKDFHTIYRHRFIDPKERDGDGFKDLIVKASDTTLDLHVRLDQREEFQPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXI5</accession>
    <name>B8LXI5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_078450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341873.1">
        <property type="nucleotide sequence ID" value="XM_002341832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXI5"/>
    <dbReference type="STRING" id="441959.B8LXI5"/>
    <dbReference type="GeneID" id="8101176"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_078450"/>
    <dbReference type="eggNOG" id="ENOG502S5YD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013856_0_0_1"/>
    <dbReference type="InParanoid" id="B8LXI5"/>
    <dbReference type="OMA" id="KYGVENR"/>
    <dbReference type="OrthoDB" id="2587563at2759"/>
    <dbReference type="PhylomeDB" id="B8LXI5"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="532"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="558"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="619"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED24486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="701" mass="77125" checksum="BCF6044BB69FE294" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8LY68</accession>
    <name>B8LY68_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_067490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340700.1">
        <property type="nucleotide sequence ID" value="XM_002340659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LY68"/>
    <dbReference type="GeneID" id="8104405"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_067490"/>
    <dbReference type="eggNOG" id="ENOG502SBD0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046903_0_0_1"/>
    <dbReference type="InParanoid" id="B8LY68"/>
    <dbReference type="OMA" id="RRFQLKF"/>
    <dbReference type="OrthoDB" id="5360255at2759"/>
    <dbReference type="PhylomeDB" id="B8LY68"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004354">
        <property type="entry name" value="Meiotic_Rec114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03525">
        <property type="entry name" value="Meiotic_rec114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="517" mass="57726" checksum="1070180DC8B97655" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYH3</accession>
    <name>B8LYH3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_063780</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340289.1">
        <property type="nucleotide sequence ID" value="XM_002340248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYH3"/>
    <dbReference type="FunCoup" id="B8LYH3">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LYH3"/>
    <dbReference type="GeneID" id="8107332"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_063780"/>
    <dbReference type="eggNOG" id="KOG1867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008279_6_0_1"/>
    <dbReference type="InParanoid" id="B8LYH3"/>
    <dbReference type="OMA" id="CEREGND"/>
    <dbReference type="OrthoDB" id="2020758at2759"/>
    <dbReference type="PhylomeDB" id="B8LYH3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02662">
        <property type="entry name" value="Peptidase_C19F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="137"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="610"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="612"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED22902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="663" mass="74627" checksum="7593D97E50EAEA12" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYK1</accession>
    <name>B8LYK1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA binding effector protein Scp160, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_067880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340746.1">
        <property type="nucleotide sequence ID" value="XM_002340705.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B8LYK1">
        <property type="interactions" value="698"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LYK1"/>
    <dbReference type="GeneID" id="8104261"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_067880"/>
    <dbReference type="eggNOG" id="KOG2208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003293_0_0_1"/>
    <dbReference type="InParanoid" id="B8LYK1"/>
    <dbReference type="OMA" id="DHAGQQV"/>
    <dbReference type="OrthoDB" id="10027144at2759"/>
    <dbReference type="PhylomeDB" id="B8LYK1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22449">
        <property type="entry name" value="KH-I_ScSCP160_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22408">
        <property type="entry name" value="KH-I_Vigilin_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054548">
        <property type="entry name" value="SCP160-like_KH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF31">
        <property type="entry name" value="DODECA-SATELLITE-BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22952">
        <property type="entry name" value="KH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="212"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="294"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="388"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="706"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="773"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="872"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="949"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="1029"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="1098"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="1219"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="813"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1134"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED23359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1295" mass="140904" checksum="68BD295BBF955BFB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZ06</accession>
    <name>B8LZ06_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_069350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340901.1">
        <property type="nucleotide sequence ID" value="XM_002340860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZ06"/>
    <dbReference type="GeneID" id="8107360"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_069350"/>
    <dbReference type="eggNOG" id="ENOG502S87B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080238_1_0_1"/>
    <dbReference type="InParanoid" id="B8LZ06"/>
    <dbReference type="OMA" id="WVLRYWE"/>
    <dbReference type="OrthoDB" id="5599753at2759"/>
    <dbReference type="PhylomeDB" id="B8LZ06"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877450" evidence="1">
        <location>
            <begin position="19"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="259" mass="29073" checksum="64D4E901F202626E" modified="2009-03-03" version="1">MAMSTSNVRMIITAVVTAAAVAAGSSSFGKELTTTTEQSAESQIRPICTTTPDNILTSNQYFIVYDRAWRTIHKSDLPSDQDLTTILGPDNGSWSYDQKLLTTYLRRNMSAFARYLPQARIIKMILRKANPQALPTLNPVVIEKLDFGVGDVVCGIYKVLRREDALLEFGIEQLSPKAESQEKKTEQQFDGRLVIGIRPASDIDSDSVEIYSETIMWRDNTKPNIIMPLERKIPKVMHELASWWLLDSGVNYLKGLKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZK8</accession>
    <name>B8LZK8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_096800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479394.1">
        <property type="nucleotide sequence ID" value="XM_002479349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZK8"/>
    <dbReference type="FunCoup" id="B8LZK8">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LZK8"/>
    <dbReference type="GeneID" id="8103523"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_096800"/>
    <dbReference type="eggNOG" id="ENOG502QPR9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005049_0_1_1"/>
    <dbReference type="InParanoid" id="B8LZK8"/>
    <dbReference type="OMA" id="FENAWMQ"/>
    <dbReference type="OrthoDB" id="3162439at2759"/>
    <dbReference type="PhylomeDB" id="B8LZK8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="12"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED22431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="636" mass="73049" checksum="B2AF0F4EFE6739FA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8M165</accession>
    <name>B8M165_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cation efflux protein/ zinc transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_082400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477970.1">
        <property type="nucleotide sequence ID" value="XM_002477925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M165"/>
    <dbReference type="STRING" id="441959.B8M165"/>
    <dbReference type="GeneID" id="8107698"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_082400"/>
    <dbReference type="eggNOG" id="KOG1483">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_4_0_1"/>
    <dbReference type="InParanoid" id="B8M165"/>
    <dbReference type="OMA" id="RATKMYA"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="PhylomeDB" id="B8M165"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF5">
        <property type="entry name" value="DIFFUSION FACILITATOR FAMILY METAL ION TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="12"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="10">
        <location>
            <begin position="250"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED21007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="348" mass="38075" checksum="5F11C458DCC94143" modified="2009-03-03" version="1">MAIRLSKRIRLRLIILISTSFFVVEIAVGFYTHSLALIADAFHYLNDLIGFVIALVALELTESTQSPPTWLSFGWQRAQILGAFFNGVFLFALGVSTALQSIEKFIFMHNDITRPENILIVACIGLVLNICSVILIHGVLVAFLFPMGSTHFLLGQIMVTIIHILAMDGQIGDVKSSHDLNSLGVLIHLLGDALNNIGVMVSALVIWLTKHEGRFYADPAASMLIACMIMLTSAPLALSSGRILIQSLPTNVNCEDVNRILTSVPGVLAVHDLRLWRLNHHKNIASVHVLIDGQTSMRECSSIMKSIRQRLHALGVHSITIQPEVVRASYVVTGVAGDNEGVVPEYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1C0</accession>
    <name>B8M1C0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="13">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSTA_090550</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 13">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="13"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478779.1">
        <property type="nucleotide sequence ID" value="XM_002478734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1C0"/>
    <dbReference type="FunCoup" id="B8M1C0">
        <property type="interactions" value="443"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M1C0"/>
    <dbReference type="GeneID" id="8101546"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_090550"/>
    <dbReference type="eggNOG" id="KOG2467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022477_0_0_1"/>
    <dbReference type="InParanoid" id="B8M1C0"/>
    <dbReference type="OMA" id="TQPFFSQ"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="PhylomeDB" id="B8M1C0"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF57">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 12 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="15">
        <location>
            <begin position="65"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EED21816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="535" mass="59048" checksum="2CF974319EBAB785" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1F1</accession>
    <name>B8M1F1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Flotillin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_090870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the band 7/mec-2 family. Flotillin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478810.1">
        <property type="nucleotide sequence ID" value="XM_002478765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1F1"/>
    <dbReference type="STRING" id="441959.B8M1F1"/>
    <dbReference type="GeneID" id="8101577"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_090870"/>
    <dbReference type="eggNOG" id="KOG2668">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030844_1_1_1"/>
    <dbReference type="InParanoid" id="B8M1F1"/>
    <dbReference type="OMA" id="IHDQTGM"/>
    <dbReference type="OrthoDB" id="6080404at2759"/>
    <dbReference type="PhylomeDB" id="B8M1F1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03399">
        <property type="entry name" value="SPFH_flotillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027705">
        <property type="entry name" value="Flotillin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806:SF31">
        <property type="entry name" value="FLOTILLIN-LIKE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806">
        <property type="entry name" value="FLOTILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="6">
        <location>
            <begin position="29"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED21847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="454" mass="50837" checksum="06911C93520F779B" modified="2009-03-03" version="1">MRYYIASANEYLVITGAGIPDLRICKKALVYPWQKISRISVTPFDFSLNLQAMTVEKLQFALPAVFTIGPDNELDALKKYALLLSGNADGTSEHKYEVNQPARRNHVQDIVKGIIEGETRVIVSSMTMEEIFKERQIFKAKVIENVQNELQQFGLRIYNANVKELQDTPGSEYFAFLSRKAHEGALNQAKIDVAEARMRGEIGEAEKKGRTKQEISKIDAETAVLETKRKAEKAKADSELTSRQIELERDIRMAKISAERQTEMRDAELRKNVESKRAETELERLRATDVTKSKIAREAAQEKADAAFYTEQKAADASFYKKKMESDAYYYRQRREAEAIQETAKAYKSMVDTLGGPQGFLQLKMIETGMYERLAQANATAVSGMQPKITTWNTGSSAGEADSTASIRNIMQSLPPLLSTIHEQTGIAPPTWFAQMPQAEANGALVAPKKVNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1W5</accession>
    <name>B8M1W5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_085740</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478306.1">
        <property type="nucleotide sequence ID" value="XM_002478261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1W5"/>
    <dbReference type="FunCoup" id="B8M1W5">
        <property type="interactions" value="1047"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M1W5"/>
    <dbReference type="GeneID" id="8104539"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_085740"/>
    <dbReference type="eggNOG" id="KOG1596">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059055_1_0_1"/>
    <dbReference type="InParanoid" id="B8M1W5"/>
    <dbReference type="OMA" id="WNPNKSK"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="PhylomeDB" id="B8M1W5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000056">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="7"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED21343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="306" mass="32102" checksum="F243B1114D1EC629" modified="2009-03-03" version="1">MAFTPRGRGGPPRGGRGGFGARGGGGGGRGGGRGGGAPRGRGGARGGRGAPRGGRGGGRGGAKGGQKVIIEPHRHAGIFIARGGKEDLLVTKNLTPGDSVYGEKRIAVESPAEGDAPAVKTEYRVWNPFRSKLAAGVLGGLDKIYIKPGSKVLYLGAASGTSVSHVADLVGPTGTVYAVEFSHRSGRDLIGMATKRTNVIPIVEDARHPMKYRLLVPMVDVIFADVAQPDQARIVGLNAHMFLKNEGGVLISIKASCIDSTAQPEVVFANEVERLRVEKIKPKEQLTLEPFERDHCIVAGLYMRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2D6</accession>
    <name>B8M2D6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CT20 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_088360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478563.1">
        <property type="nucleotide sequence ID" value="XM_002478518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2D6"/>
    <dbReference type="STRING" id="441959.B8M2D6"/>
    <dbReference type="GeneID" id="8106933"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_088360"/>
    <dbReference type="eggNOG" id="KOG4051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050564_2_0_1"/>
    <dbReference type="InParanoid" id="B8M2D6"/>
    <dbReference type="OMA" id="QHTRIPY"/>
    <dbReference type="OrthoDB" id="5595141at2759"/>
    <dbReference type="PhylomeDB" id="B8M2D6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012423">
        <property type="entry name" value="Eaf7/MRGBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581">
        <property type="entry name" value="MRG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581:SF5">
        <property type="entry name" value="MRG_MORF4L-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07904">
        <property type="entry name" value="Eaf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="150"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="226"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED21600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="32814" checksum="1F2A5CD6311766CE" modified="2009-03-03" version="1">MPPRKRPKLSSRATSSTPQVETTKQPTSANSTTGSAQKSDTENDLINDPWTDEQETALLKSIVRWKPVGMHKHFRMLAIAEYMKSQGYAPADEEHTRIPGIWKKLSSLYNLPALDEREDSIISRDADESDGSEYCPFELPEDEYGEMMFAKRLAAERSESPAETSVHPESRRGSTVADTDEPRSSPAPSRGRRGKPTRASTRGTRSTRLQVEVERPSSSSVATEDEHMEDADADEEDGEEGDSDAGEAEGDNDGEEADAETASSPTTRSTRTQTAKSKKDKKSAAASSTTTRRTGRRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-07-27" modified="2025-02-05" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2W9</accession>
    <name>AMPP2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName>Probable Xaa-Pro aminopeptidase TSTA_094700</fullName>
            <ecNumber>3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Prolidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">TSTA_094700</name>
    </gene>
    <organism>
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479187.1">
        <property type="nucleotide sequence ID" value="XM_002479142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2W9"/>
    <dbReference type="SMR" id="B8M2W9"/>
    <dbReference type="STRING" id="441959.B8M2W9"/>
    <dbReference type="GeneID" id="8103800"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_094700"/>
    <dbReference type="eggNOG" id="KOG2737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_1_2_1"/>
    <dbReference type="InParanoid" id="B8M2W9"/>
    <dbReference type="OMA" id="YELRMIR"/>
    <dbReference type="OrthoDB" id="10261878at2759"/>
    <dbReference type="PhylomeDB" id="B8M2W9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF3">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE AN0832-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0031">Aminopeptidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000411853" description="Probable Xaa-Pro aminopeptidase TSTA_094700">
        <location>
            <begin position="1"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="503" mass="55848" checksum="670A4356FAFBA5D8" modified="2009-03-03" version="1">MSPSPALHAAAFQGIGAPDIQRFHINLSVGSNVNRYPAKQHARKVASKLGISRGLIYLVGKPTVFLDDSDQTIPFRQRRYFYYLSGANEPDCHLTYDIAKDHLTLYVPDFDLRQTVWMGPTISIGEALDRYDIDNARYAGSLQTDISGWLRLRGDDSQIILLHPDHRPPIEYEQDLFETKNLVPAMNAARGVKDSYEIEMIRKANIVSGLAHTAVLEKIGQMTNESDIAGLFLETCMTHGAPDQAYGIIAASGENGATLHYMKNNEDFGNRLSVCLDAGAEYECYASDVTRTFPISRTGEWPTPEVRDIYLAVERMQEECIRLIKPGVRFRDVHLHASRVAVEELLKLGVFQKDNSVDAIMASGAVSVFFPHGLGHHVGLEVHDVAEQSVMAATDDSSPRTRVRGFLMQPASAMSAALLEESMIVTVEPGIYFNRLALKNARTLPIARFIDFDVVERYYPIGGVRIEDDILVTATGYENLTTAPKGEEALDIIRRSSVKSSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3G5</accession>
    <name>B8M3G5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_095860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479300.1">
        <property type="nucleotide sequence ID" value="XM_002479255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3G5"/>
    <dbReference type="STRING" id="441959.B8M3G5"/>
    <dbReference type="GeneID" id="8105897"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_095860"/>
    <dbReference type="eggNOG" id="ENOG502QVPF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006197_0_0_1"/>
    <dbReference type="InParanoid" id="B8M3G5"/>
    <dbReference type="OMA" id="ARGKYTM"/>
    <dbReference type="OrthoDB" id="3989227at2759"/>
    <dbReference type="PhylomeDB" id="B8M3G5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF79">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="167"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="632"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="840"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="899"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="982"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1046"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="632"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="849"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="899"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="933"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="988"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1013"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1046"/>
            <end position="1058"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED22337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1163" mass="128105" checksum="8A41673449F20EF3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3X9</accession>
    <name>B8M3X9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Purine permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_039230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481156.1">
        <property type="nucleotide sequence ID" value="XM_002481111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3X9"/>
    <dbReference type="STRING" id="441959.B8M3X9"/>
    <dbReference type="GeneID" id="8109261"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_039230"/>
    <dbReference type="eggNOG" id="ENOG502QQD4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017959_7_0_1"/>
    <dbReference type="InParanoid" id="B8M3X9"/>
    <dbReference type="OMA" id="GLGFDWN"/>
    <dbReference type="OrthoDB" id="1641903at2759"/>
    <dbReference type="PhylomeDB" id="B8M3X9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042907">
        <property type="term" value="F:xanthine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
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    </dbReference>
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    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="546"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="567"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED20722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="589" mass="62377" checksum="D3171BBDBD8210EC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8M417</accession>
    <name>B8M417_TALSN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_039570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20760.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M417"/>
    <dbReference type="GeneID" id="8109295"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_039570"/>
    <dbReference type="eggNOG" id="ENOG502SWU6">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_946995_0_0_1"/>
    <dbReference type="InParanoid" id="B8M417"/>
    <dbReference type="OMA" id="IEIGRYQ"/>
    <dbReference type="OrthoDB" id="4219272at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED20760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="316" mass="34977" checksum="CB589C262C0E6210" modified="2009-03-03" version="1">MAPTVTTTKTTSILKLPLDTRNDPSLLHFNQLVYIPETGIWAPGKKSTPIFDFSSHFDRSSVSWFTDDYVGFNEDVMAQAKEIALAAISNDQNAAEDIPNPSVIFKLSRTHWYNDSKLTATKPVYDRRLLDALDSESDVDSIRKQKLQNLEDAQEHQKENRNEIVLAESSSPLLAFGVTNITFPSNSLHSSHPITVRPTNATRRSQSFVHDSVSYAWDVNKTLFPGGGAVLSLYKGVGSTKKIEIGRYQSDNGKVIPGGVMVIDSDEVDVLIAVLTLLAVLAQRDSTLLDFVILCNGCSGTMWISLEIGKWNSEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8M436</accession>
    <name>B8M436_TALSN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">TSTA_039740</name>
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    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M436"/>
    <dbReference type="GeneID" id="8109312"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_039740"/>
    <dbReference type="HOGENOM" id="CLU_1289707_0_0_1"/>
    <dbReference type="InParanoid" id="B8M436"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED20779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="214" mass="23799" checksum="7C95BFF5C46C14B9" modified="2009-03-03" version="1">MVLMSPPSIRTAIPLFILWQKKLGQVEAARFLVNKGADVAAVNAKGNTPLHEVMGGLLRDKRATRGPKYKTLRLADILRAQNEMITVIQDGSGYSNKLMDQPNAVECSVTPIGYQALAWQNSFCCLDFPTRICPLLDGNYVNAQFEGTAMREAPTRFEMYHIPSPRLYGAMPNMDPIALSTTMDGRSRDYRYMVRLVSLFEATAGAGKEIGQYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8M441</accession>
    <name>B8M441_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Barwin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_039780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481218.1">
        <property type="nucleotide sequence ID" value="XM_002481173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M441"/>
    <dbReference type="GeneID" id="8109316"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_039780"/>
    <dbReference type="HOGENOM" id="CLU_1723606_0_0_1"/>
    <dbReference type="InParanoid" id="B8M441"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="PhylomeDB" id="B8M441"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002874701" description="Barwin domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="14573" checksum="C1C8E0CB57268531" modified="2009-03-03" version="1">MKSTVATIAVSALLLGSQVAVANPIQKRDIPSSFYSNMAIDGSIYSFADDASCNEIFYTAGSFAMASAVMSQFGASQNNELCGKTIEITGANGVVQQAAIADTAGADIIDMCLNLWEDFGGQDGDGTIMTGANGIQWRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4K0</accession>
    <name>B8M4K0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_025170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479629.1">
        <property type="nucleotide sequence ID" value="XM_002479584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4K0"/>
    <dbReference type="STRING" id="441959.B8M4K0"/>
    <dbReference type="GeneID" id="8106734"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_025170"/>
    <dbReference type="eggNOG" id="ENOG502S3EX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8M4K0"/>
    <dbReference type="OMA" id="EYGMQKQ"/>
    <dbReference type="OrthoDB" id="5400327at2759"/>
    <dbReference type="PhylomeDB" id="B8M4K0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF5">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="229"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="564"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="587"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="605" mass="65844" checksum="E2C32FCBDA940DC5" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4T2</accession>
    <name>B8M4T2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="6">PPIase</shortName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_026730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479801.1">
        <property type="nucleotide sequence ID" value="XM_002479756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4T2"/>
    <dbReference type="STRING" id="441959.B8M4T2"/>
    <dbReference type="GeneID" id="8098953"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_026730"/>
    <dbReference type="eggNOG" id="KOG0881">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_16_3_1"/>
    <dbReference type="InParanoid" id="B8M4T2"/>
    <dbReference type="OMA" id="ELYNDHA"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="PhylomeDB" id="B8M4T2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000008">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="8"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED19367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="162" mass="17800" checksum="4956B3ED5B92C6DB" modified="2009-03-03" version="1">MATEIAIDTTMGSFVVELYNDHAPKTCKNFATLAQRGYYNGVIFHRIIPDFMIQGGDPTGTGRGGSSIYGEKFEDEIHPSLKHTGAGILSMANSGPNTNGSQFFITLAPTPWLDGKHTIFGRIKSGMRVIQRMGLVKTDAEDRPQDPVKIIKARVREEGEED</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4Y9</accession>
    <name>GET3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPase get3</fullName>
            <ecNumber evidence="1">3.6.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Arsenical pump-driving ATPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Arsenite-stimulated ATPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Golgi to ER traffic protein 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Guided entry of tail-anchored proteins 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">get3</name>
        <name type="ORF">TSTA_027210</name>
    </gene>
    <organism>
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arsA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="1"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479858.1">
        <property type="nucleotide sequence ID" value="XM_002479813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4Y9"/>
    <dbReference type="SMR" id="B8M4Y9"/>
    <dbReference type="FunCoup" id="B8M4Y9">
        <property type="interactions" value="981"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M4Y9"/>
    <dbReference type="GeneID" id="8109640"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_027210"/>
    <dbReference type="eggNOG" id="KOG2825">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040761_0_0_1"/>
    <dbReference type="InParanoid" id="B8M4Y9"/>
    <dbReference type="OMA" id="MDAPYEF"/>
    <dbReference type="OrthoDB" id="1770at2759"/>
    <dbReference type="PhylomeDB" id="B8M4Y9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000235">
        <property type="entry name" value="ATPase ASNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03112">
        <property type="entry name" value="Asna1_Get3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027542">
        <property type="entry name" value="ATPase_ArsA/GET3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000388233" description="ATPase get3">
        <location>
            <begin position="1"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03112"/>
        </source>
    </evidence>
    <sequence length="340" mass="37502" checksum="EA51B456053B9C4E" modified="2009-03-03" version="1">MSSTALIHDDEALEPTLQSILDQKTLRWIFVGGKGGVGKTTTSCSLAIQLSKVRKSVLLISTDPAHNLSDAFGQKFGKEARLVDGFTNLSAMEIDPNGSIQDLLASGGEAQDDPLAGLGMGGMMQDLAFSIPGVDEAMSFAEVLKQVKSLSYEVIVFDTAPTGHTLRFLQFPTVLEKALAKLSQLSGQFGPMLNSILGSRGGLPGGQNLDDLMSKMESLRETISEVNTQFKNADMTTFVCVCIAEFLSLYETERMIQELTGYSIDTHAIVVNQLLFPKKDNPCEQCNARRKMQKKYLEQIEELYEDFNVVRMPLLVEEVRGKEKLEKFSEMLVKPYVPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4Z2</accession>
    <name>B8M4Z2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Eukaryotic translation initiation factor 3 subunit E</fullName>
            <shortName evidence="4">eIF3e</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">INT6</name>
        <name evidence="8" type="ORF">TSTA_027240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the eIF-3 subunit E family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479861.1">
        <property type="nucleotide sequence ID" value="XM_002479816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4Z2"/>
    <dbReference type="STRING" id="441959.B8M4Z2"/>
    <dbReference type="GeneID" id="8109643"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_027240"/>
    <dbReference type="eggNOG" id="KOG2758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031132_0_0_1"/>
    <dbReference type="InParanoid" id="B8M4Z2"/>
    <dbReference type="OMA" id="NCPWILR"/>
    <dbReference type="OrthoDB" id="417252at2759"/>
    <dbReference type="PhylomeDB" id="B8M4Z2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21378">
        <property type="entry name" value="eIF3E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03004">
        <property type="entry name" value="eIF3e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016650">
        <property type="entry name" value="eIF3e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019010">
        <property type="entry name" value="eIF3e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10317">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09440">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21357">
        <property type="entry name" value="EIF3E_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016255">
        <property type="entry name" value="eIF3e_su6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01186">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="257"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED19427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="452" mass="51969" checksum="6DBD5E13F25D7667" modified="2009-03-03" version="1">MADNAPPSAETLLNGAAAHPPKTAEEIAKEYDLLPKLIPYLDRHLVFPLLEFISGQDDDNLELTRSKYELLKHTNMTDYVANLWQEINNSDTIPEEFVRKREGVLAKLQQYQEDSEKITELLQDDAVVGNLRSDKVANLKFLEEQHGVTVDMVNTLFDYGRFQYSCGSYGNAAELLYQFRVLSTDNDKVSSATWGKFACEILTTNWEAAMEEVQKVKDLIETRLFNNPLGQLQHRSWLIHWSLFPYFNHEPARDVLTDLFFSPAYINTIQTNCPWILRYLAAAVITNRSRAHKNTSTYQKQLKDLIRVVRQEGYEYSDPITDFIKALYVEFDFEEAQKKLGEAEELLRCDFFLVSAADAFVDAARHLISESYCKIHQRIDIKDLSTRLGLGQDEGEKWIVNLIRDTRVDAKIDYKEGTVIMNHPPQSVYQQVIERTKGAFFRTQVLSAAVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5C3</accession>
    <name>B8M5C3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_030000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ERGIC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480163.1">
        <property type="nucleotide sequence ID" value="XM_002480118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5C3"/>
    <dbReference type="FunCoup" id="B8M5C3">
        <property type="interactions" value="366"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M5C3"/>
    <dbReference type="GeneID" id="8106567"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_030000"/>
    <dbReference type="eggNOG" id="KOG2667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034705_2_0_1"/>
    <dbReference type="InParanoid" id="B8M5C3"/>
    <dbReference type="OMA" id="MTNHYLR"/>
    <dbReference type="OrthoDB" id="5541786at2759"/>
    <dbReference type="PhylomeDB" id="B8M5C3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF81">
        <property type="entry name" value="ER-DERIVED VESICLES PROTEIN ERV41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="7">
        <location>
            <begin position="24"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="6">
        <location>
            <begin position="189"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED19729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="400" mass="45756" checksum="7341330389E46F7D" modified="2009-03-03" version="1">MNGFSKHELDEDAFGEKRNAEAGLKTFDAFPKTKPNYTTPSRRGGQWTVIIIAICTFLSIGELITWYRGTENQHFSVEKGVSRQLQMNIDMVVKMPCNDIRVNVQDASGDHIMAGMLLMKDSTNWEMWNEKLNQQSSGVTEYQTLNAEDTKRLLEQEEDMHAHHVLSHTRRNPRRKFPKTPRLSAKYPTDSCRIYGSLESNKVHGDFHITARGHGYNELGEHLDHKTFNFTHMITELSFGPHYPSLLNPLDKTVAYTEDHYYKFQYFLNVVPTIYAKGNNAVEKYTANPALAFKKSRNTIFTNQYSATSQSHALPENPYNTPGIFFKYNIEPILLFVSEERGSFLALLVRLVNVVSGVIVTGGWLYQLSGWAMEVLRRRRRGGYSQGVLNGRTHSAEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5I3</accession>
    <name>B8M5I3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_031370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480311.1">
        <property type="nucleotide sequence ID" value="XM_002480266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5I3"/>
    <dbReference type="STRING" id="441959.B8M5I3"/>
    <dbReference type="GeneID" id="8107748"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_031370"/>
    <dbReference type="eggNOG" id="ENOG502QS59">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025989_0_0_1"/>
    <dbReference type="InParanoid" id="B8M5I3"/>
    <dbReference type="OMA" id="LGWNEPK"/>
    <dbReference type="OrthoDB" id="1708389at2759"/>
    <dbReference type="PhylomeDB" id="B8M5I3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021709">
        <property type="entry name" value="DUF3292"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38694">
        <property type="entry name" value="CONSERVED EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38694:SF1">
        <property type="entry name" value="PEROXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11696">
        <property type="entry name" value="DUF3292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="680" mass="74669" checksum="4BBC0C4902393128" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5Q6</accession>
    <name>B8M5Q6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Clustered mitochondria protein homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein TIF31 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CLU1</name>
        <name evidence="4" type="synonym">TIF31</name>
        <name evidence="8" type="ORF">TSTA_032090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">May associate with the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CLU family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480384.1">
        <property type="nucleotide sequence ID" value="XM_002480339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5Q6"/>
    <dbReference type="FunCoup" id="B8M5Q6">
        <property type="interactions" value="1000"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M5Q6"/>
    <dbReference type="GeneID" id="8099822"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_032090"/>
    <dbReference type="eggNOG" id="KOG1839">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003256_2_0_1"/>
    <dbReference type="InParanoid" id="B8M5Q6"/>
    <dbReference type="OMA" id="HPVWDKD"/>
    <dbReference type="OrthoDB" id="1414216at2759"/>
    <dbReference type="PhylomeDB" id="B8M5Q6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000293">
        <property type="entry name" value="Clustered mitochondria protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000532">
        <property type="entry name" value="Clustered mitochondria protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03013">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028275">
        <property type="entry name" value="CLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15044">
        <property type="entry name" value="CLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Clu" evidence="7">
        <location>
            <begin position="309"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="962"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="589"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="856"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1164"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="589"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="863"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1164"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1174"/>
            <end position="1193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED19950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1238" mass="137495" checksum="B039CB05955B651C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8M630</accession>
    <name>B8M630_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphorylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_023650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479464.1">
        <property type="nucleotide sequence ID" value="XM_002479419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M630"/>
    <dbReference type="STRING" id="441959.B8M630"/>
    <dbReference type="GeneID" id="8109547"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_023650"/>
    <dbReference type="eggNOG" id="ENOG502QRAQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049915_0_0_1"/>
    <dbReference type="InParanoid" id="B8M630"/>
    <dbReference type="OMA" id="GSDMFCP"/>
    <dbReference type="OrthoDB" id="10267950at2759"/>
    <dbReference type="PhylomeDB" id="B8M630"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="2">
        <location>
            <begin position="89"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="1">
        <location>
            <begin position="184"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="289" mass="32493" checksum="D463AE0C10C63522" modified="2009-03-03" version="1">MACEFTATTPPDYKSVMAKFDALIARGLISCYPPEVVRLQDKNLQTLKSCAKFEFRVSQTLQAKPQSGEPLPLSKGNTFGPGSDLALVHADLVLAEINNTHLLVANLYCVIRPQLLLLTKDSYRRQHESLGADDFDVIKEPFYAMFSCSAMAGASREHKHMHILPYEDKNECTGIPSVEAQLSSFPFKYYWSRVDFSEGNLLQIYYRLLADARLALNLAQSATCPHNVILTQYWLMVVLRRSNNFHGLTCNAPGMICSVWLQNEAQLKKWSQLGLAKVLSRLGVPKDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7T6</accession>
    <name>B8M7T6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Vacuolar protein sorting protein Vps66, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_030780</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480249.1">
        <property type="nucleotide sequence ID" value="XM_002480204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7T6"/>
    <dbReference type="FunCoup" id="B8M7T6">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M7T6"/>
    <dbReference type="GeneID" id="8101757"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_030780"/>
    <dbReference type="eggNOG" id="ENOG502RYF8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048121_0_0_1"/>
    <dbReference type="InParanoid" id="B8M7T6"/>
    <dbReference type="OMA" id="WFRFLWD"/>
    <dbReference type="OrthoDB" id="272512at2759"/>
    <dbReference type="PhylomeDB" id="B8M7T6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF60">
        <property type="entry name" value="LYSOPHOSPHATIDIC ACID:OLEOYL-COA ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="10">
        <location>
            <begin position="104"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED19815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="338" mass="38025" checksum="D7A9EEA80B30AA95" modified="2009-03-03" version="1">MEKYSQFRDRGSGIAPFLPVPTSKSGYALPLHIFLFCFRLPLLIFVCLSYFVVLQWLPIGSLGKKASLWCILGVPSLWWIDLQVDGVKRGRLASQRARLPISNCIIASSFTSPIDPVYLAAVFDPVFTASYPNTRKVERLSLLQAILRSFAYPLVNPPPDTQLVELSELLEKYKSRPVAVFAECTTTNGRGILPLSRSLVSVPPRSKIYPVSLRYTEADVTTPVPGTYITFLWNLLSRPTHFIRVRVAEYVTTSNKNLSLSSQAHSTSTDFFDDDEPTSFFEEYAGSNKDSELTKSEVAVLDYVGESLARLGRVKRVGLGVKEKQDFVDLWTRNKRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7X1</accession>
    <name>B8M7X1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_031130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480284.1">
        <property type="nucleotide sequence ID" value="XM_002480239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7X1"/>
    <dbReference type="GeneID" id="8107724"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_031130"/>
    <dbReference type="HOGENOM" id="CLU_1548641_0_0_1"/>
    <dbReference type="InParanoid" id="B8M7X1"/>
    <dbReference type="OrthoDB" id="3000060at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED19850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="173" mass="19826" checksum="06599321B612FA27" modified="2009-03-03" version="1">MKPAPLSLRMKISMTSEPPEDLVLKYEEYAHRDPKGERRIDIDTFGVYIAGRVSGGLPKLRMDDVKLVYSEMLATGILRSALDVEESQEMSEILFVKYTRRMSNPFFGPIDSGLPSSRLKARWEYLRLIPSGDYCREEDQEVLRAGIMCFGLIRKRRKLDCAARQYLSAKPGE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-07-27" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8M853</accession>
    <name>PFF1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vacuolar membrane protease</fullName>
            <ecNumber evidence="6">3.4.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">FXNA-related family protease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">TSTA_032680</name>
    </gene>
    <organism>
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in vacuolar sorting and osmoregulation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M28 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="6"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480449.1">
        <property type="nucleotide sequence ID" value="XM_002480404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M853"/>
    <dbReference type="SMR" id="B8M853"/>
    <dbReference type="FunCoup" id="B8M853">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M853"/>
    <dbReference type="GeneID" id="8105007"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_032680"/>
    <dbReference type="eggNOG" id="KOG2194">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006412_1_0_1"/>
    <dbReference type="InParanoid" id="B8M853"/>
    <dbReference type="OMA" id="FCHTFVN"/>
    <dbReference type="OrthoDB" id="76293at2759"/>
    <dbReference type="PhylomeDB" id="B8M853"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03875">
        <property type="entry name" value="M28_Fxna_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000057">
        <property type="entry name" value="Vacuolar membrane protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048024">
        <property type="entry name" value="Fxna-like_M28_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053975">
        <property type="entry name" value="PFF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053976">
        <property type="entry name" value="PFF1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF58">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22250">
        <property type="entry name" value="PFF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22251">
        <property type="entry name" value="PFF1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000411744" description="Vacuolar membrane protease">
        <location>
            <begin position="1"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=1" evidence="3">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="topological domain" description="Vacuolar" evidence="1">
        <location>
            <begin position="38"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=2" evidence="3">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="405"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=3" evidence="3">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="topological domain" description="Vacuolar" evidence="1">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=4" evidence="3">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=5" evidence="3">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="topological domain" description="Vacuolar" evidence="1">
        <location>
            <begin position="522"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=6" evidence="3">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="547"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=7" evidence="3">
        <location>
            <begin position="660"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="topological domain" description="Vacuolar" evidence="1">
        <location>
            <begin position="681"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=8" evidence="3">
        <location>
            <begin position="697"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="718"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=9" evidence="3">
        <location>
            <begin position="727"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="topological domain" description="Vacuolar" evidence="1">
        <location>
            <begin position="748"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="586"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="614"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P38244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P80561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="985" mass="109430" checksum="6C6581E2E0EA19D2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8F4</accession>
    <name>B8M8F4_TALSN</name>
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        <recommendedName>
            <fullName evidence="6">nicotinamidase</fullName>
            <ecNumber evidence="6">3.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Nicotinamide deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_036880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.19" evidence="6"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480901.1">
        <property type="nucleotide sequence ID" value="XM_002480856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8F4"/>
    <dbReference type="FunCoup" id="B8M8F4">
        <property type="interactions" value="434"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M8F4"/>
    <dbReference type="GeneID" id="8100534"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_036880"/>
    <dbReference type="eggNOG" id="KOG4003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_13_0_1"/>
    <dbReference type="InParanoid" id="B8M8F4"/>
    <dbReference type="OMA" id="DFVDSWP"/>
    <dbReference type="OrthoDB" id="3341310at2759"/>
    <dbReference type="PhylomeDB" id="B8M8F4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019363">
        <property type="term" value="P:pyridine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01011">
        <property type="entry name" value="nicotinamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052347">
        <property type="entry name" value="Isochorismatase_Nicotinamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080:SF2">
        <property type="entry name" value="LD05707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080">
        <property type="entry name" value="PYRAZINAMIDASE/NICOTINAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="8">
        <location>
            <begin position="12"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED20467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="242" mass="26435" checksum="7873FA4B2B7AA50A" modified="2009-03-03" version="1">MASQAETTFVPALIVVDMQEDFCPPNGSLAVQGGRTIAPLINTLLSLPAFKIRIGTQDWHPQDHISFASNHPPPNNDPFESYIEMTNPAPGKQNETKPQRLWPVHCVASTPGAEIIPEIVADKLDILAKKGMDTRVEMYSVFSDAFQNMDPSLFKSSVDVDVTATLKQRNVTDVFVVGLAGDYCVKYTAIDAARAGFRSFVVEDAVKSVDPGEGWKQALKEFEEVGVKVVKSDGPEVGRVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8G1</accession>
    <name>B8M8G1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Triadin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_036950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480908.1">
        <property type="nucleotide sequence ID" value="XM_002480863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8G1"/>
    <dbReference type="STRING" id="441959.B8M8G1"/>
    <dbReference type="GeneID" id="8100541"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_036950"/>
    <dbReference type="HOGENOM" id="CLU_698640_0_0_1"/>
    <dbReference type="InParanoid" id="B8M8G1"/>
    <dbReference type="OMA" id="EANKWAN"/>
    <dbReference type="OrthoDB" id="10452933at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877371" evidence="2">
        <location>
            <begin position="21"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED20474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="395" mass="42494" checksum="75D69188D003BF24" modified="2009-03-03" version="1">MRVTVSKAFILSLLASNALAFQPETESNELEKKYVGSVSTLASRWAQLTAPLEARHHTEAQIAAKKAAKAKGSKHVGRAVQAADAEPEVKENAVEDKAKGKKKGKKGKKGKKGAKKVAEVSKREAAEEDEELDLEARATEPEPEVQPNVVEDKAKKGKKKGKKGKKGKKGAKKAAEVTKRETAEDAEELDASTEDAAELDARSAEPEPEVEENVLEDRAKKGKKKGKKGKKGKKGAKKAAEVTRRNAAEDEELDSTEEAGELEARSPEAEPEVNENVEDKAKKGKKKGKKGKKGKKGAKKVAEATKRDDAAEENGEVDSPEADDEAEVTKREASPEAEELDLQEADEAGELDARSAEAEPEVEENVLEDRAKKGKKKGKKGKKGKKGAKKVAETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8N6</accession>
    <name>B8M8N6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_037670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480983.1">
        <property type="nucleotide sequence ID" value="XM_002480938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8N6"/>
    <dbReference type="STRING" id="441959.B8M8N6"/>
    <dbReference type="GeneID" id="8102143"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_037670"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_26_3_1"/>
    <dbReference type="InParanoid" id="B8M8N6"/>
    <dbReference type="OMA" id="PEYWRIN"/>
    <dbReference type="OrthoDB" id="2251794at2759"/>
    <dbReference type="PhylomeDB" id="B8M8N6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877596" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="3">
        <location>
            <begin position="642"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED20549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="944" mass="104222" checksum="5D6B9D6DB21D46E7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9S0</accession>
    <name>B8M9S0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_118410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482064.1">
        <property type="nucleotide sequence ID" value="XM_002482019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9S0"/>
    <dbReference type="STRING" id="441959.B8M9S0"/>
    <dbReference type="GeneID" id="8099765"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_118410"/>
    <dbReference type="eggNOG" id="ENOG502SMNR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060598_0_0_1"/>
    <dbReference type="InParanoid" id="B8M9S0"/>
    <dbReference type="OMA" id="KCVKTGR"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="PhylomeDB" id="B8M9S0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF13">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN MOC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED18072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="45767" checksum="85229E6BF096E392" modified="2009-03-03" version="1">MAGSVVTRRRDMKCKTKMKTGCSTCRPLCQKCVKTGRTCDGYDSPFRIFTGEPIKNAYASSIKSVVSSQPTSIRVTFQDIDLLSRHFSTKTLFNVNLGCDEEARQILQTSLTDPLVRHALLSLRALREDLETVGDGDASFAHQTSRHRYGLRQYTIALGGLASNLSSSGSSELKSALLCCQIFISIEQVRKNYSAMAQHIIKGLRIMHEYRARPYYDAANNLLPALHDQLPFLDVFIIKLFVAPCKFTDPPVTAEISDTPLSACPLASQQQPVGSRTIAPDMRTELTRIAALTLGFLDKVSRVETVETALRLVPEKATLLDSLGSWLNDLELVQTEYGPSGPEPISVSFLRIFHIILKIVLLGALDSPPDLYADLRDESDRLQALANEVDGRVRTYITCSGSNGNREEISTMSD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-07-27" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9W2</accession>
    <name>AMPP1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName>Probable Xaa-Pro aminopeptidase P</fullName>
            <shortName>AMPP</shortName>
            <shortName>Aminopeptidase P</shortName>
            <ecNumber>3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Prolidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ampp</name>
        <name type="ORF">TSTA_118800</name>
    </gene>
    <organism>
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482106.1">
        <property type="nucleotide sequence ID" value="XM_002482061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9W2"/>
    <dbReference type="SMR" id="B8M9W2"/>
    <dbReference type="FunCoup" id="B8M9W2">
        <property type="interactions" value="393"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M9W2"/>
    <dbReference type="MEROPS" id="M24.009"/>
    <dbReference type="GeneID" id="8108554"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_118800"/>
    <dbReference type="eggNOG" id="KOG2413">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011781_2_2_1"/>
    <dbReference type="InParanoid" id="B8M9W2"/>
    <dbReference type="OMA" id="EPGMILS"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="PhylomeDB" id="B8M9W2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000010">
        <property type="entry name" value="Probable Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000007">
        <property type="entry name" value="Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000003">
        <property type="entry name" value="Xaa-pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0031">Aminopeptidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000411811" description="Probable Xaa-Pro aminopeptidase P">
        <location>
            <begin position="1"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="562"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="576"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="576"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="657" mass="73137" checksum="6E3EA0AED3557264" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAN1</accession>
    <name>B8MAN1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">40S ribosomal protein S10b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_112860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
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        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED17455.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="161" mass="18238" checksum="6DE4435F7D2BC3E5" modified="2009-03-03" version="1">MLIPKADRKKIHEYLFREGVLVAKKDFNLPKHGEIDTKNLYVIKALQSLDSRGYVKTRFSWQYYYYTLTPEGLDYLREWLHVPAEIVPATHIKQQRSHAPPRGMLGGEERERRPGGRGGPRGDRDGGYRRRDEGKEGGAPGEFAPTFRGGFGRGRGAAPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_002482631.1"/>
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    <dbReference type="STRING" id="441959.B8MAY3"/>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_124130"/>
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    <dbReference type="HOGENOM" id="CLU_000315_7_0_1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="434"/>
            <end position="630"/>
        </location>
    </feature>
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        <location>
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            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="265"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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        </location>
    </feature>
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        </location>
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    </feature>
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        </location>
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        <location>
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        </location>
    </feature>
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        </location>
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        <location>
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    </feature>
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        <location>
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        </location>
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        <location>
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        </location>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED18684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1210" mass="137357" checksum="1221AB75B94AC27E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MB91</accession>
    <name>B8MB91_TALSN</name>
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        <recommendedName>
            <fullName evidence="2">DNA ligase D 3'-phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">TSTA_125910</name>
    </gene>
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        <name type="synonym">Penicillium stipitatum</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_125910"/>
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    <dbReference type="PhylomeDB" id="B8MB91"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="InterPro" id="IPR014144">
        <property type="entry name" value="LigD_PE_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39465:SF1">
        <property type="entry name" value="DNA LIGASE D 3'-PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
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    <dbReference type="PANTHER" id="PTHR39465">
        <property type="entry name" value="DNA LIGASE D, 3'-PHOSPHOESTERASE DOMAIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF13298">
        <property type="entry name" value="LigD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA ligase D 3'-phosphoesterase" evidence="2">
        <location>
            <begin position="125"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED18880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="450" mass="51253" checksum="CD50B48953C7A43B" modified="2009-03-03" version="1">MKRSHSPETPRPFRNRNISQDRTRTRTLSSLTSSVSPPRLKKSASRVDRYHSNRPKNDDTTSLSLAAVEAGQVKIDDPVELFSARLAAASRPVSTFTEGSRLPVKDWIDLYSRNQHENGCHFVIHQHDHPIAGPHYDLRLQFSESSSLSWAIMYGLPGNPNSSRLNRNATETRVHCLWNHLIETGSSNTGSMIIWDTGEYEVLPYNATENPLETEDSASDASTISAEFPIREQRPSESEKLRQAFQNRKIRLRLHGTRLPKNYTMSLRLSMEDDNAARARPTNQKRRRRRINPAFMKPVRTPSTSRSPSPEIAHRQSSNSVRTINDNHGEEDIHGSHSASESESEQAADMKTRLTNAYPGAVNSIGSVHQRRWFITLDRMNSGFIRDSKRKIWKRKEATCDQDVSGFEPFYVRGPEFERSVVTGRTGNEVLKDENVEGFIPRRGWRPVLN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-03-08" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBN3</accession>
    <name>CHO2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidylethanolamine N-methyltransferase</fullName>
            <shortName evidence="1">PE methyltransferase</shortName>
            <shortName evidence="1">PEAMT</shortName>
            <shortName evidence="1">PEMT</shortName>
            <ecNumber evidence="1">2.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">cho2</name>
        <name type="ORF">TSTA_119300</name>
    </gene>
    <organism>
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11164"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.1.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.17" evidence="1"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482158.1">
        <property type="nucleotide sequence ID" value="XM_002482113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBN3"/>
    <dbReference type="SMR" id="B8MBN3"/>
    <dbReference type="FunCoup" id="B8MBN3">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MBN3"/>
    <dbReference type="GeneID" id="8104380"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119300"/>
    <dbReference type="eggNOG" id="ENOG502QRGH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005987_0_0_1"/>
    <dbReference type="InParanoid" id="B8MBN3"/>
    <dbReference type="OMA" id="RIWYSVG"/>
    <dbReference type="OrthoDB" id="4583at2759"/>
    <dbReference type="PhylomeDB" id="B8MBN3"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004608">
        <property type="term" value="F:phosphatidylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2840:FF:000006">
        <property type="entry name" value="Phosphatidylethanolamine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03217">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016219">
        <property type="entry name" value="Phosphatid-EA_MeTrfase_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138:SF0">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000383">
        <property type="entry name" value="PEAMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51598">
        <property type="entry name" value="SAM_CHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000405919" description="Phosphatidylethanolamine N-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="106"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="133"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="219"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="247"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="301"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="324"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="422"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="496"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="532"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="600"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="705"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="706"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="717"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="991" mass="112035" checksum="34669CF02EE5DCCF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBU0</accession>
    <name>B8MBU0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_119800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482215.1">
        <property type="nucleotide sequence ID" value="XM_002482170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBU0"/>
    <dbReference type="FunCoup" id="B8MBU0">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="GeneID" id="8105255"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119800"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="B8MBU0"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="PhylomeDB" id="B8MBU0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
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    </dbReference>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="EED18481.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="876" mass="98418" checksum="13ECA49586A9B5FB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCE3</accession>
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            <fullName evidence="2">4-hydroxyphenylpyruvate dioxygenase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">TSTA_124780</name>
    </gene>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.</text>
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    <dbReference type="InParanoid" id="B8MCE3"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:L-tyrosine catabolic process"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0223">Dioxygenase</keyword>
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    <keyword evidence="6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0828">Tyrosine catabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED18759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="116" mass="13144" checksum="B946C3C295ABF6D8" modified="2009-03-03" version="1">MTVEQDMQNLQQSSILVDFDEGGYLFQLLTKPLLDKPTVFLKAIQRHDFAGFGAGNVKDYIVGSSIVTRDDERGQGDRDPMTRVNEPVDLAKALCHSCWPFQDFLFVIFGRSIFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCP9</accession>
    <name>B8MCP9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_126590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED18951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="132" mass="15466" checksum="8045478431979533" modified="2009-03-03" version="1">MIPIPDNLEYAVDPDFWGLSLNLEDEEQHVPKTINTYIAWLQECYDLHDCEGEDLWNTFWEDFEGFTLDLFKVATRPAVRGLRDYLPSAGALSYAHVLYECLHEETQADWTEEALENKAKVIKKWEDLRAKI</sequence>
</entry>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="484"/>
            <end position="512"/>
        </location>
    </feature>
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        </location>
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        </location>
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        <location>
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            <begin position="572"/>
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        </location>
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        <source>
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        <source>
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        <source>
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        <source>
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    <sequence length="585" mass="64167" checksum="E66003C7FF489439" modified="2009-03-03" version="1"> </sequence>
</entry>
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    <accession>B8MED5</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        </subcellularLocation>
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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        </location>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED16562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="159" mass="16955" checksum="6A7F2CE8C7433A23" modified="2009-03-03" version="1">MASAEMDIDPPVGDNTTPSQSGNSEAKTQAGAVAVRSIEGWIIIATNIHEEASEEDVTDLFAEYGEIKNFNLNLDRRTGYVKGYALIEYSTLPEAKAAIDALNGAKLLDQTLSVDYAFVRPPPGNKGKGGGNQRGGRGGRARSRSRERSRSPGADNGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEP8</accession>
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        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484165.1">
        <property type="nucleotide sequence ID" value="XM_002484120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEP8"/>
    <dbReference type="STRING" id="441959.B8MEP8"/>
    <dbReference type="GeneID" id="8108801"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_019900"/>
    <dbReference type="eggNOG" id="KOG1712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003324_0_0_1"/>
    <dbReference type="InParanoid" id="B8MEP8"/>
    <dbReference type="OMA" id="GKDYCAE"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="PhylomeDB" id="B8MEP8"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005919">
        <property type="entry name" value="Pmev_kin_anim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF25">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04275">
        <property type="entry name" value="P-mevalo_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="312"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="902"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="905"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED16931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1150" mass="126916" checksum="0E4671FAFFADB150" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8MER3</accession>
    <name>B8MER3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_020050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484180.1">
        <property type="nucleotide sequence ID" value="XM_002484135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MER3"/>
    <dbReference type="GeneID" id="8108816"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_020050"/>
    <dbReference type="HOGENOM" id="CLU_618444_0_0_1"/>
    <dbReference type="InParanoid" id="B8MER3"/>
    <dbReference type="OMA" id="PFKMESA"/>
    <dbReference type="OrthoDB" id="4227381at2759"/>
    <dbReference type="PhylomeDB" id="B8MER3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="327"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED16946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="443" mass="49980" checksum="FA893043B5C2AB49" modified="2009-03-03" version="1">MGLNTTFTKHQHRQSDDLLALGCVSQCHDQPSPKATKGNDYTLRLDQIKTNNSDDNIDGDGPWSNNTIDVANSLSSSSSVYSASEEPNNSTECTVKIATDSETSARSSSIVSRNQESVRSIASSVGVTSVSSHYSQKCNQEEEQQKQKRKSDELKHTLSFSSLRKIKSLEKIPFKMESALMAFRWLCRKSDELIQRGDIETDDHQIQKLQEITPDLGAIIVQRMERLEEKIDILFSTTSKSTRSTIDESSSTYQSILDPDADTPVEQPLYKTYNQTPLQAQKKEHTETIQQTEFKILTAEINHLIKSNNNLSSCIDALGSSGLIDLLEMLSCSLERLHSAINSLRERQQQQQNLDSINNEEGDNQLRLQIDIIQSLGFLLGQREEQLRHERKLNQSYRENIEGLEGMISALEVEWKKVSPFISNSECMTDCIGRLKRGTIVRT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-04-05" modified="2025-02-05" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8MF81</accession>
    <name>PEPA_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Penicillopepsin-1</fullName>
            <ecNumber evidence="1">3.4.23.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Aspartic protease pepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">pepA</name>
        <name type="ORF">TSTA_012870</name>
    </gene>
    <organism>
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Secreted aspartic endopeptidase that allows assimilation of proteinaceous substrates. The scissile peptide bond is attacked by a nucleophilic water molecule activated by two aspartic residues in the active site. Shows a broad primary substrate specificity. Favors hydrophobic residues at the P1 and P1' positions, but can also activate trypsinogen and hydrolyze the B chain of insulin between positions 'Gly-20' and 'Glu-21'.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but also cleaving 20-Gly-|-Glu-21 in the B chain of insulin. Clots milk, and activates trypsinogen.</text>
            <dbReference type="EC" id="3.4.23.20"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.20" evidence="1"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483414.1">
        <property type="nucleotide sequence ID" value="XM_002483369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MF81"/>
    <dbReference type="SMR" id="B8MF81"/>
    <dbReference type="STRING" id="441959.B8MF81"/>
    <dbReference type="GlyCosmos" id="B8MF81">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="GeneID" id="8108163"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_012870"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_0_0_1"/>
    <dbReference type="InParanoid" id="B8MF81"/>
    <dbReference type="OMA" id="DEEYIGN"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="PhylomeDB" id="B8MF81"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000024">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000026">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF2">
        <property type="entry name" value="ASPERGILLOPEPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0064">Aspartyl protease</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000407061" description="Activation peptide" evidence="3">
        <location>
            <begin position="20"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000407062" description="Penicillopepsin-1">
        <location>
            <begin position="67"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="85"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="5">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="315"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P00798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q01972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q12567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4"/>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <sequence length="387" mass="39923" checksum="52949806E4AEE95D" modified="2009-03-03" version="1" precursor="true">MVNSKTVVSALALSALAAAAPAPSSTTSFSINQVAVKKPAIHPAVKYAKALAKYHAEIPSNVASAAASAQSGSATNKPTADDEEYVTPITAGSSTLHLDFDTGSADLWTYSASTRGVGSHSTYDTSTGKKVSGASWQISYGDGSSASGVVYKDKVVVGGVTASSQAVEVATQVSSEFSQDTSNDGLLGLAFSSINTVSPTPQKTFYDNVKSSLAKPVFAVTLKHQAPGTYDFGFIDKSKYKGSLAYTNVDNSQGFWQFTADGYSIGGSGGGSSFSAIADTGTTLVLLDDSIVDEYYSQVQGAQNDSSQGGYVFDCSADLPDFGVQIGDYTAVIPGKYINYASTGSTCFGGIQSNSGIGFSILGDVFLKSQYVVFDGDNLQLGFAAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFE3</accession>
    <name>B8MFE3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RTA1 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_017520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483911.1">
        <property type="nucleotide sequence ID" value="XM_002483866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFE3"/>
    <dbReference type="STRING" id="441959.B8MFE3"/>
    <dbReference type="GeneID" id="8109009"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_017520"/>
    <dbReference type="eggNOG" id="ENOG502RUBP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033465_6_1_1"/>
    <dbReference type="InParanoid" id="B8MFE3"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="PhylomeDB" id="B8MFE3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED16677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="34929" checksum="99C3AB41008D9C92" modified="2009-03-03" version="1">MWSNCTTVGPNCPADGSGLSYPPNLAANIIFAALFGFSLIVHIFQGWRLRTWSFLAAYALGSSTEVVGYIGRILFHSNPYDLNRFLVQIVCLTMGPAFYSAGLYLCLARIVIVYGEEISRIRPAWYTRIFITCDLISLALQGGGGGVASSATKPSTLSMGNNIMLAGLIFQIVTLVLFAVLCLEFSWRVHRSPHMKNVQFRSLRDSRRFRGFLLAAVATFVLIFVRCVYRVVELAGGWNNHLQREEVPFIILESGMITVAVFVFAVYHPGYAFKDVFGALRASVSSNDIQKGEIVEMRPESVETLFRPNKQAASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8MG19</accession>
    <name>B8MG19_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_010040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483120.1">
        <property type="nucleotide sequence ID" value="XM_002483075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MG19"/>
    <dbReference type="GeneID" id="8102800"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_010040"/>
    <dbReference type="eggNOG" id="ENOG502SFM8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1918484_0_0_1"/>
    <dbReference type="InParanoid" id="B8MG19"/>
    <dbReference type="OMA" id="NTNCVIT"/>
    <dbReference type="OrthoDB" id="3497702at2759"/>
    <dbReference type="PhylomeDB" id="B8MG19"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877723" evidence="1">
        <location>
            <begin position="19"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="132" mass="13527" checksum="FE6F5B2478DCACC0" modified="2009-03-03" version="1">MKFSIASSLTLLATSVAALPSGFVARQSYDNITFTIINDQTGAQAAATVLIDGIPNGFQDLFGSSPLASNGKILATSTQLIAFPQGVDCAITNSAQAVVGHLTPSHTWLDLDGNPNAAIPVDVSGDSITCSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MH37</accession>
    <name>B8MH37_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S acidic ribosomal protein P0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_019130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL10 forms part of the P stalk that participates in recruiting G proteins to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484085.1">
        <property type="nucleotide sequence ID" value="XM_002484040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MH37"/>
    <dbReference type="FunCoup" id="B8MH37">
        <property type="interactions" value="1370"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MH37"/>
    <dbReference type="GeneID" id="8104609"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_019130"/>
    <dbReference type="eggNOG" id="KOG0815">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053173_1_1_1"/>
    <dbReference type="InParanoid" id="B8MH37"/>
    <dbReference type="OMA" id="DMNPFKL"/>
    <dbReference type="OrthoDB" id="10259902at2759"/>
    <dbReference type="PhylomeDB" id="B8MH37"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="6">
        <location>
            <begin position="109"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR039087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED16851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="313" mass="33294" checksum="1E4AFDCCB3EE39EF" modified="2009-03-03" version="1">MGGKSASKAAYFDKLKGLLDEYKTIFIVSVDNVSSQQMHEIRLSLRGEGVVLMGKNTMVRRALKGFIAENPEYERLLPFVKGNVGFIFTNAELKGVRTKILSNRVAAPARAGAIAPADVFVPAGNTGMEPGKTSFFQALGVPTKIARGTIEITTDLKLVEAGAKVGASEAVLLNMLNISPFTYGMSITQIYDDGQTFGSEVLDIEDEQLLKALSSAITTISTISLATSYPTLPSVMHSLVNSYKKVLAVAIETDFSWPEIEELKDRIANPEAYAAAAPVAAAATGGEAAPAAAEEKEESEEESGDEGFGGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHK6</accession>
    <name>B8MHK6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_011030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483221.1">
        <property type="nucleotide sequence ID" value="XM_002483176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHK6"/>
    <dbReference type="STRING" id="441959.B8MHK6"/>
    <dbReference type="GeneID" id="8109876"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_011030"/>
    <dbReference type="eggNOG" id="ENOG502SANZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059580_1_1_1"/>
    <dbReference type="InParanoid" id="B8MHK6"/>
    <dbReference type="OMA" id="MMLDDTK"/>
    <dbReference type="OrthoDB" id="5345504at2759"/>
    <dbReference type="PhylomeDB" id="B8MHK6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046591">
        <property type="entry name" value="DUF6649"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20354">
        <property type="entry name" value="DUF6649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="178" mass="20173" checksum="AF24F9EAFD5E7504" modified="2009-03-03" version="1">MPSLDSPLKRHAESDLEGEPPIKKLELLHLGSTVSADEQAKQQDELTDSDNVMMLDDTKHTSYIYDIERELASIEAEEKRISFLPDIEKALNAIPKSILSEPKPEQNELVLYRVPRSLTVAEDQDNVRKAIIESRARARARHTERSTYSPSIVPPSDDRDNLVFTFEADDVMDVDSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHL2</accession>
    <name>B8MHL2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_011080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483227.1">
        <property type="nucleotide sequence ID" value="XM_002483182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHL2"/>
    <dbReference type="STRING" id="441959.B8MHL2"/>
    <dbReference type="GeneID" id="8109881"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_011080"/>
    <dbReference type="eggNOG" id="ENOG502S3UT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052209_0_0_1"/>
    <dbReference type="InParanoid" id="B8MHL2"/>
    <dbReference type="OMA" id="TAFHLWS"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="PhylomeDB" id="B8MHL2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED15993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="47319" checksum="BC0F6C316DA722F6" modified="2009-03-03" version="1">MIWLRYLPRNPRYLRQCRAFTTGSTRIVSVPVRIRRPWFRRFATSVLAYGVAFHVWTTLVYLQLDGSTVSESASSGSPRALSEGRIIEGNGKILDDDEVEDASFIPLSWPRLRPGELYKGSDPEWKTFQEYARDKQKMDTLRKELQTLVLAKLSTQREFVHLLGGKPLRVSDSWLMVHCPYRAPPQYETLGLAIVDNEATLISKPIPREQGQLLTAALFPSAVASAVLAAGKVLWKRKVQRFKNYLGADEERSTKEAIMKIKNMDIQSDMSPSTNVSLQNFADWEKSLSSGAAEEINRSAASGMSDTTRSQPQPDTSRTPKILSLMQSLSSQYKGSDFYVAYLAFNLHFKRNRALQRKVPPRGVFYLSGPIGIKGGKGECRVEVRGEYDPAEKKWCSLMVDLKDLRPYNQSPLGYHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8MI46</accession>
    <name>B8MI46_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ankyrin repeat-containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_022620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484442.1">
        <property type="nucleotide sequence ID" value="XM_002484397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MI46"/>
    <dbReference type="STRING" id="441959.B8MI46"/>
    <dbReference type="GeneID" id="8107099"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_022620"/>
    <dbReference type="eggNOG" id="KOG0508">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_674693_0_0_1"/>
    <dbReference type="InParanoid" id="B8MI46"/>
    <dbReference type="OrthoDB" id="4507899at2759"/>
    <dbReference type="PhylomeDB" id="B8MI46"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="330"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="366"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED17208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="408" mass="46251" checksum="66B92F82B89BA96A" modified="2009-03-03" version="1">MADLFLSQHGNKHVSERWVYRFVDRHPEVKLRFSRRYNYERAKCEDIKLIPLDGLCPHTLSSKQQPFINKAGLRLFHKIGDLILVKMAGQQMRLEYDGFKNTLFLLRQAPLDVNCFAVLKRQYGRLVEQRVRLGFNHIDKYDFLTAFPEARTMAYKAENIQNGFKATELVPFDPDRVYQKLTVELRTPTPPPSRSSNSQSSCQQTPQNPRQFNRQTATIKKINEPTTGPFEVVDQAINRLSKAYEMSRNELLIIQKEVHDLRAANEKEKQKRKRSRAQISHQGSLTAQEAQELITSRECVFGGNWPARCPITLVHWLLEKGADVNTQGGEFGNALQAAVEGGRLEIVERLLEKGADVNAQGGLYGNALQVAVEGGHLKIVQRLLENGADVNAQGGYYSNALQTAFAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8MI80</accession>
    <name>B8MI80_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">L-kynurenine/alpha-aminoadipate aminotransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_040440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484517.1">
        <property type="nucleotide sequence ID" value="XM_002484472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MI80"/>
    <dbReference type="STRING" id="441959.B8MI80"/>
    <dbReference type="GeneID" id="8110001"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_040440"/>
    <dbReference type="eggNOG" id="KOG0634">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_950537_0_0_1"/>
    <dbReference type="InParanoid" id="B8MI80"/>
    <dbReference type="OrthoDB" id="3358371at2759"/>
    <dbReference type="PhylomeDB" id="B8MI80"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008793">
        <property type="term" value="F:aromatic-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF21">
        <property type="entry name" value="AROMATIC_AMINOADIPATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NmrA-like" evidence="6">
        <location>
            <begin position="7"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED14564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="293" mass="32361" checksum="CE2F36B05E4CE082" modified="2009-03-03" version="1">MSSTQSQQTIVVVGATGIQGSGVVRALLSDEYGGPWFVRALTQDPRSGKAQKLLSECQTTDNRLSLVSGHIYDETSLRSAFMGAHGVFAMTSERYPGKLITEEEELKPSRPLSIGEVLESNSNSSLRHQPLGIRIAAAKMDEQGLLSEDMYELLSNWDEKACSAAKPHLLYTVPSGQSPTGATQSAQRRQVYKVCQKYDIFIGEDEPYCFLQVEPYKAGVPPPSSCEEFLKVLLSSFLKVDVDGRVLRLESFSKVLSPGTRTGWIVGSEQIVERFAHHFESPERNTPATLREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MI86</accession>
    <name>B8MI86_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_040500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484523.1">
        <property type="nucleotide sequence ID" value="XM_002484478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MI86"/>
    <dbReference type="GeneID" id="8110007"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_040500"/>
    <dbReference type="eggNOG" id="KOG1121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036639_0_0_1"/>
    <dbReference type="InParanoid" id="B8MI86"/>
    <dbReference type="OMA" id="YLIWITH"/>
    <dbReference type="OrthoDB" id="4507940at2759"/>
    <dbReference type="PhylomeDB" id="B8MI86"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="374"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED14570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="51312" checksum="586D3DE49D097B8F" modified="2009-03-03" version="1">MRPRSGTTTDRAHTTAILAAVTAQVNSKKPDITTTLSKIRSLAVFVNASPQHRDTFYALQTTATKILPIQDVKTRWNSTFLMLRRTKRLQAIFIPFCTEWERPDLLLNNEEWRQVDYLIWITHPFYEFTTELSKTKDVTTHHVFKIYNLLFKHLESTIIQLKRKSIPWKKNMLQALEAGQEKLDYYYSMTDAIPGDLYAVSTMLAPDNKFKFFQTKNWDDELRVRYRESFKESLISYVERFTTQQAPPIFQPSHKTGSHLGLLLKKGKYQPAKPKDEFTKYLDSAIAALARDALSVSVTGAGIKWLFNIAWDICHYRCGKLHAVTIQELILFLCASRFKIDQEQHFFISDFLSQDEIESAKEEEIPAEFELELISDNEEQRTEEERREEDRDDFEDEASPHPVIDVSLPVIEEKTTQVRQSVRLRKRPREKDDQYIYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8MI88</accession>
    <name>B8MI88_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Retrotransposon polyprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_040520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484525.1">
        <property type="nucleotide sequence ID" value="XM_002484480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MI88"/>
    <dbReference type="STRING" id="441959.B8MI88"/>
    <dbReference type="GeneID" id="8110009"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_040520"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_33_2_1"/>
    <dbReference type="InParanoid" id="B8MI88"/>
    <dbReference type="OMA" id="WEYISVD"/>
    <dbReference type="OrthoDB" id="4499277at2759"/>
    <dbReference type="PhylomeDB" id="B8MI88"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="2">
        <location>
            <begin position="416"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase zinc-binding" evidence="3">
        <location>
            <begin position="661"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED14572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="754" mass="87536" checksum="5F9455EEC7C8823F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIG4</accession>
    <name>B8MIG4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_041260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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    <sequence length="241" mass="26024" checksum="300819436015A2D8" modified="2009-03-03" version="1">MHFFIAGGSGQTGTHVINKLIQQGHTVTALVRNPSSITPRVGVKLVQGTPSNIDDIRKALQTPRTPDVIIITLAHVKGAVFDDRGTTFLTYVARNIAQCLEESQMMTTKIIYMSAFGVGDSFPNLNCLMRVLVRVSPLASQFSDHKGAEDTLQSIATDADGRKAVVTIVRPTMLTNGEEAKVQSLGSRGEKASFMPSIPRASVADFMVDAAQIDKCDGKVVVIANAKSTLVDIIPYSWYNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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                <person name="Fedorova-Abrams N.D."/>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="GeneID" id="8099499"/>
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    <dbReference type="eggNOG" id="ENOG502S8Z8">
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            <end position="434"/>
        </location>
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        </location>
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        <source>
            <dbReference type="EMBL" id="EED15073.1"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    <sequence length="545" mass="61014" checksum="E1B032BD15C62316" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GLYCOPROTEIN 38"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED14742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="599" mass="64186" checksum="5C8ACC83A4E32584" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="2">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_4_0_1"/>
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    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="162"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED14745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="443" mass="49546" checksum="35EC14FA8F7A8168" modified="2009-03-03" version="1">MVNEADILKAISDLESQKEPQYAKTARKYNLEPSTLRRRYKGQTASNQEATSMHRKLLTDAQEEVLLNHISKLSSRGLPPTPQILRNLVVELIQHDVGDPSNIYNFDEKGFNIGLCRTEKRIISKSQLRSKKLLGAIQDGSTEFITLIACICANRATTNSRIRGRYRLLILDGHGSHLTPQFDRICAENDIIPVCMPAHSSHLLQPLDVGCFAVLKRAYGRVVSDLARNSYNHIDKLDFLADYPRARIKAFQPSIIQNSFAATGLVPINPERVLLKLNISLRTPTPPSSRPSSRSSQFTPKTPKTAVQLQKQASMLKELLKQRSNSPPSPSKIILDQIIKGHYQALHHTALLAQENANLRIANEKKCRKRNRSTRQIVHEGGLSVEEGLQLAQQENQQVEGSGLVSHEQGALPTQQDQPRRRALPKCSGCGDIGHKINQCKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8ML03</accession>
    <name>B8ML03_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Benzoate 4-monooxygenase cytochrome P450, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_048590</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485372.1">
        <property type="nucleotide sequence ID" value="XM_002485327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ML03"/>
    <dbReference type="STRING" id="441959.B8ML03"/>
    <dbReference type="GeneID" id="8107041"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_048590"/>
    <dbReference type="eggNOG" id="KOG0159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="InParanoid" id="B8ML03"/>
    <dbReference type="OMA" id="VIYTTRN"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="PhylomeDB" id="B8ML03"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF180">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED15419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="559" mass="63177" checksum="FD8D201024660C98" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8MM06</accession>
    <name>B8MM06_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_097740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485756.1">
        <property type="nucleotide sequence ID" value="XM_002485711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MM06"/>
    <dbReference type="GeneID" id="8108413"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_097740"/>
    <dbReference type="HOGENOM" id="CLU_1235762_0_0_1"/>
    <dbReference type="InParanoid" id="B8MM06"/>
    <dbReference type="OMA" id="WISDEFD"/>
    <dbReference type="OrthoDB" id="4215820at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED13518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="224" mass="24543" checksum="9682E31264EF4DB3" modified="2009-03-03" version="1">MPDGTRIDGSSFKWNPLEGARYQGADRGAYTWFNVCPGTGDNALDDQDPSIDSNLPAYSRNGPVIWPTPHNYISYGDSYAAGIGGHCGWIRDEFDESLEGDDCCRCEESYPFQLQSAGPQMQGATLYFPACSGAIINDMENSNENGRRSQMGNDLHFADAALNCLFWYDEGKCTSALAYAANKLNDASFRLALAEVYSNIILDSYGQRAPTAQMGFLLIVTGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MM14</accession>
    <name>B8MM14_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_097820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485764.1">
        <property type="nucleotide sequence ID" value="XM_002485719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MM14"/>
    <dbReference type="GeneID" id="8108421"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_097820"/>
    <dbReference type="HOGENOM" id="CLU_013929_8_1_1"/>
    <dbReference type="InParanoid" id="B8MM14"/>
    <dbReference type="OrthoDB" id="4502298at2759"/>
    <dbReference type="PhylomeDB" id="B8MM14"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="50"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED13526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="176" mass="20715" checksum="A6E873948A8C0862" modified="2009-03-03" version="1">MPPIRNKNKKDLAEQEGRILLAISDLQNGRILRVAQAARIYSISRATLRDRLNGTQQRSQCEEESLVRWILDLDKRGLPPRHSLVREMADYLLLQRGNQYVGESWVYNLVKRRPEIESNFSRKYSYERAKCEDPKIIQGYFNRVREVILEYGILQEDIYNFDETGFAMELCATQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8MN17</accession>
    <name>B8MN17_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_102010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486204.1">
        <property type="nucleotide sequence ID" value="XM_002486159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MN17"/>
    <dbReference type="STRING" id="441959.B8MN17"/>
    <dbReference type="GeneID" id="8099246"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_102010"/>
    <dbReference type="eggNOG" id="ENOG502SSB8">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_046870_3_0_1"/>
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    <dbReference type="OMA" id="FWANCAG"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="PhylomeDB" id="B8MN17"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
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        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="34"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED13966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="360" mass="41159" checksum="3C4FC182C3EF6AE6" modified="2009-03-03" version="1">MDEPVFTMHARVSKPVFLGMLWAFTAVSFLFVLFRIVVRYGSFRRLYLDDFFVLLAWSIMLTTAIIWQIQGQVLYEIYAISAGTQSYTPDTLPKFLKFMRFIAPLTILFYSSLWCVKFSFLAFFFRLGSKIQSHRIWWYVVLAVTAAVWISSVADIDYKCSLGGLEDILIQCSDLRHVQYENRTFWANCAGDVITDLLILSIPVLMLWNIRISIGKKLILLAVFSATILIMAVAIIRVVINIDLDRSVDISWLYFWSFIEMGTAIIISCIASFRQLFVTSQNQHLYGKAAYRTPYQKLPNIGRKGYGPGESGPRGEGNTESQRSAVGATIVPLDVLYVRKEFEVANVPATKRPPLNREWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNQ8</accession>
    <name>B8MNQ8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetratricopeptide repeat and J domain-containing co-chaperone DNJ1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_103680</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486385.1">
        <property type="nucleotide sequence ID" value="XM_002486340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNQ8"/>
    <dbReference type="STRING" id="441959.B8MNQ8"/>
    <dbReference type="GeneID" id="8103071"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_103680"/>
    <dbReference type="eggNOG" id="KOG0624">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015935_0_1_1"/>
    <dbReference type="InParanoid" id="B8MNQ8"/>
    <dbReference type="OMA" id="PFAHFQH"/>
    <dbReference type="OrthoDB" id="1726119at2759"/>
    <dbReference type="PhylomeDB" id="B8MNQ8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ and TPR domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000224">
        <property type="entry name" value="DnaJ and TPR domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051727">
        <property type="entry name" value="DnaJ_C3_Co-chaperones"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140:SF2">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002875256" description="Tetratricopeptide repeat and J domain-containing co-chaperone DNJ1" evidence="9">
        <location>
            <begin position="21"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="10">
        <location>
            <begin position="400"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="462"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED14147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="526" mass="58076" checksum="3CDA71900094D8C6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B8MP74</accession>
    <name>B8MP74_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Lysophospholipase NTE1</fullName>
            <ecNumber evidence="3 16">3.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Intracellular phospholipase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TSTA_105250</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the NTE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="3 16"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486551.1">
        <property type="nucleotide sequence ID" value="XM_002486506.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B8MP74">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MP74"/>
    <dbReference type="GeneID" id="8098746"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_105250"/>
    <dbReference type="eggNOG" id="KOG2968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_1_1_1"/>
    <dbReference type="InParanoid" id="B8MP74"/>
    <dbReference type="OMA" id="SSGYVWR"/>
    <dbReference type="OrthoDB" id="421051at2759"/>
    <dbReference type="PhylomeDB" id="B8MP74"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034638">
        <property type="term" value="P:phosphatidylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071071">
        <property type="term" value="P:regulation of phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000062">
        <property type="entry name" value="Lysophospholipase NTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000007">
        <property type="entry name" value="Lysophospholipase NTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000018">
        <property type="entry name" value="Lysophospholipase NTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001423">
        <property type="entry name" value="LysoPLipase_patatin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056556">
        <property type="entry name" value="NTE1_P-loop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF29">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE SWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24179">
        <property type="entry name" value="NTE_Ploop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01237">
        <property type="entry name" value="UPF0028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 15 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15 16" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11 15 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="18">
        <location>
            <begin position="706"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="18">
        <location>
            <begin position="851"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="19">
        <location>
            <begin position="1230"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="293"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="483"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="753"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="15">
        <location>
            <begin position="1234"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="15">
        <location>
            <begin position="1261"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="15">
        <location>
            <begin position="1381"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="483"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="770"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="15">
        <location>
            <position position="1263"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="1381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EED14313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1533" mass="169266" checksum="65F300C10D27CB65" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MP95</accession>
    <name>B8MP95_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_105450</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486572.1">
        <property type="nucleotide sequence ID" value="XM_002486527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MP95"/>
    <dbReference type="FunCoup" id="B8MP95">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MP95"/>
    <dbReference type="GeneID" id="8098766"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_105450"/>
    <dbReference type="eggNOG" id="ENOG502QSWP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025694_1_2_1"/>
    <dbReference type="InParanoid" id="B8MP95"/>
    <dbReference type="OMA" id="WAPHTYD"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="PhylomeDB" id="B8MP95"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="396"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED14334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="469" mass="51610" checksum="89B4FE4ADCBDF1C6" modified="2009-03-03" version="1">MLSKIRKPGHVIPTILLATKVVRAIDLNLDDTDSIKSAAKTAATEMMTYYTGYRPGDNPGNLPDPYYWWEAGAMFGALVDYWAYTGDSTWNNMTTQALLWQASPDANFMPKNQTMTEGNDDQAFWGMAAMSAAERNFPNPPPDQPQWLALAQAVFNSQAARWDPTTCGGGLRWQIFTWNKGYGYKNTISNGGFFNIASRLAKYTGNQTYAEWADKTWQWTVDVGFLTPEYRFWDGADDATDCKNYNLIEWTYNSGVYLLGAANMYNYTNGSDIWRDRTLHILNATNVFFSTDPEKVMYERACEPVGTCQVDQKSFKAHLARWMAATTQMAPFTYDIIMPRLRTSALAAAKTCTGGPNGTSCGLKWTEQKWDGNRGVGEQMSALEVIQSNLIHEVAPPVTDANGGTSRGNPAAGSGPNGRPSGSGDASQGKSGDFRTREITTADRAGAGILTTLFLAGVVGGTGWMIYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPJ1</accession>
    <name>B8MPJ1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_106390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486668.1">
        <property type="nucleotide sequence ID" value="XM_002486623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPJ1"/>
    <dbReference type="STRING" id="441959.B8MPJ1"/>
    <dbReference type="GeneID" id="8098891"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_106390"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="1">
        <location>
            <begin position="109"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="497" mass="56184" checksum="05139B02CC2464E1" modified="2009-03-03" version="1">MAEKTMQPYSLLVHGTSTTTELLHEIASNNNINAESIEDIYPCTPLQIGLLSLTSRNPTDYVLHEILELNTTTSLDKFCAAWEEVYRTKPLFTPSFGLKETARNHRILETDSGQPLSRYAIIKGQPGKKSSFIWTIHHSLFDGWFLSLVVTRRVSELYLCHPCEQMIEFKTFVAHMLEKNNTEAEQYWASALQGFDSGHFLAPSSSRTRVQPENLRVEQHFGQARLQDHHHIRRSVLAYAAWAITMSIETKSGDVVFGGINSGRQADVYGIKQIAGPTISTVPIRVNVRLHKKVSDFLEEIERDAQDRVRFEYLGLSRIAKINSSTNRACEFQTLVVIQPTANDLYMDPAVGNWKPESKDLMATAYRLVIQMFFENNGTRLAADYNPNAIDGRTVHRLLAEFTLLMKQLAEADAGRRTMGDLELLSGDEQERLWLWNMNALSTIERCVHDLIEEQVQLRPDALAIQAWDGQLTYSELGGLATSLRISWSPKGSVPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPX2</accession>
    <name>B8MPX2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SWI-SNF complex subunit (Snf5), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_053760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486973.1">
        <property type="nucleotide sequence ID" value="XM_002486928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPX2"/>
    <dbReference type="STRING" id="441959.B8MPX2"/>
    <dbReference type="GeneID" id="8098327"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_053760"/>
    <dbReference type="eggNOG" id="KOG1649">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018784_0_0_1"/>
    <dbReference type="InParanoid" id="B8MPX2"/>
    <dbReference type="OMA" id="KYAWLPR"/>
    <dbReference type="OrthoDB" id="515064at2759"/>
    <dbReference type="PhylomeDB" id="B8MPX2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="444"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="503"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="564"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="618"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="575"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="633"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="688"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED12862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="808" mass="89612" checksum="FFB43241C0C06E7A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQ53</accession>
    <name>B8MQ53_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial carrier protein PET8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_055790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487190.1">
        <property type="nucleotide sequence ID" value="XM_002487145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQ53"/>
    <dbReference type="GeneID" id="8102272"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_055790"/>
    <dbReference type="eggNOG" id="ENOG502SEH2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2086400_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQ53"/>
    <dbReference type="OMA" id="AKYERIK"/>
    <dbReference type="OrthoDB" id="529205at2759"/>
    <dbReference type="PhylomeDB" id="B8MQ53"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED13079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="12908" checksum="19DF6289D7DA0A3E" modified="2009-03-03" version="1">MASLPYIRQTIRPFTATSLSLGSAPVCSSTASFSTSSIQRALKESDRNRDGLENEYETYKNENLKDVKSGKGYWREQLASESEATVKADRGEAVIPGQENFVKGGLKEGETLKKDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQB1</accession>
    <name>B8MQB1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_058020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487424.1">
        <property type="nucleotide sequence ID" value="XM_002487379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQB1"/>
    <dbReference type="STRING" id="441959.B8MQB1"/>
    <dbReference type="GeneID" id="8108938"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_058020"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022195_9_3_1"/>
    <dbReference type="InParanoid" id="B8MQB1"/>
    <dbReference type="OMA" id="RANPIGE"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="PhylomeDB" id="B8MQB1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED13313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="529" mass="60458" checksum="9619E37A544DCAA9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQD9</accession>
    <name>B8MQD9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_058300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487452.1">
        <property type="nucleotide sequence ID" value="XM_002487407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQD9"/>
    <dbReference type="GeneID" id="8106432"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_058300"/>
    <dbReference type="eggNOG" id="KOG3105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1556308_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQD9"/>
    <dbReference type="OrthoDB" id="4207519at2759"/>
    <dbReference type="PhylomeDB" id="B8MQD9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED13341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="20184" checksum="765F8C0C21503174" modified="2009-03-03" version="1">MIIKMAASSQSIRRLWHMMFLDRAFKDTSKGPKGAVTLLQILENLQILKNLLLLHGYWIWEDVAYHHKYQLVSLSTASIGEKWVNRFVKRHDELSAKYTRKYDYQRAKCEDPELIKDWFERVRDTIQKYGIIEQDIYNMDETGFQMGIISTAKALQPGNREWVTAIEAINTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQL9</accession>
    <name>B8MQL9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_059280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487553.1">
        <property type="nucleotide sequence ID" value="XM_002487508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQL9"/>
    <dbReference type="STRING" id="441959.B8MQL9"/>
    <dbReference type="GeneID" id="8107398"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_059280"/>
    <dbReference type="eggNOG" id="KOG1369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014393_4_0_1"/>
    <dbReference type="InParanoid" id="B8MQL9"/>
    <dbReference type="OMA" id="HYPHYKE"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="PhylomeDB" id="B8MQL9"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24000">
        <property type="entry name" value="ASKHA_NBD_HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF29">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="7">
        <location>
            <begin position="23"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="8">
        <location>
            <begin position="278"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED13442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="589" mass="65233" checksum="0BEB78C71B13BFAB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQZ3</accession>
    <name>B8MQZ3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phospholipase D</fullName>
            <ecNumber evidence="1">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_053460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.4.4" evidence="1"/>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486939.1">
        <property type="nucleotide sequence ID" value="XM_002486894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQZ3"/>
    <dbReference type="STRING" id="441959.B8MQZ3"/>
    <dbReference type="GeneID" id="8098297"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_053460"/>
    <dbReference type="eggNOG" id="KOG1329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000690_2_2_1"/>
    <dbReference type="InParanoid" id="B8MQZ3"/>
    <dbReference type="OMA" id="ILYWAHH"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="PhylomeDB" id="B8MQZ3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF186">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="939"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
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        </location>
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            <end position="60"/>
        </location>
    </feature>
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        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
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        <location>
            <begin position="420"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="466"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
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            <end position="538"/>
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            <begin position="581"/>
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    </feature>
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        <location>
            <begin position="651"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012027"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED12828.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1173" mass="131155" checksum="F4951B4B3C7F3C87" modified="2009-03-03" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRL0</accession>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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        <property type="protein sequence ID" value="EED13167.1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="8100730"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_056670"/>
    <dbReference type="eggNOG" id="KOG2914">
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    </dbReference>
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    <dbReference type="InParanoid" id="B8MRL0"/>
    <dbReference type="OMA" id="IWCPHPG"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="PhylomeDB" id="B8MRL0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="HAD superfamily hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain"/>
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    </dbReference>
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        <property type="entry name" value="HAD superfamily/HAD-like"/>
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    </dbReference>
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        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED13167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="293" mass="32733" checksum="7C0FC573FE54748F" modified="2009-03-03" version="1">MPSTELPRIRACLFDMDGLLLNTEDIYTTITNSVLQEYGKPNMPWSLKAQLQGRPAPEATKIFHDWAHLPISRDEYAAKIAEKQQKLFPEAAPLPGVVKLLNDLHATSNTSQPVYIALATSSHKRNYELKTGHLQDLFSLFPKSRQVLGDDPRIGKGRGKPLPDIYLLALETINQELCEKEEEPIKPEECLVFEDAVPGVEAGRRAGMQVVWCPHPNVLDVYKGREEEVLAGLTGEHKEEEKTDAEKEADELQGERLAQTNNSGTPGKLNDGFARIFSTLENFPYGEYGIVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRT8</accession>
    <name>B8MRT8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_057620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002487338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRT8"/>
    <dbReference type="STRING" id="441959.B8MRT8"/>
    <dbReference type="GeneID" id="8108898"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_057620"/>
    <dbReference type="eggNOG" id="ENOG502RV0S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025283_0_0_1"/>
    <dbReference type="InParanoid" id="B8MRT8"/>
    <dbReference type="OMA" id="WGPTPNT"/>
    <dbReference type="OrthoDB" id="4733706at2759"/>
    <dbReference type="PhylomeDB" id="B8MRT8"/>
    <dbReference type="Proteomes" id="UP000001745">
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488262.1">
        <property type="nucleotide sequence ID" value="XM_002488217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSS6"/>
    <dbReference type="STRING" id="441959.B8MSS6"/>
    <dbReference type="GeneID" id="8105318"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_006330"/>
    <dbReference type="eggNOG" id="ENOG502SHR2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027370_1_0_1"/>
    <dbReference type="InParanoid" id="B8MSS6"/>
    <dbReference type="OMA" id="SHAICVQ"/>
    <dbReference type="OrthoDB" id="5343576at2759"/>
    <dbReference type="PhylomeDB" id="B8MSS6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="530" mass="58031" checksum="3F53234C58FA8DAF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8MT74</accession>
    <name>B8MT74_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 13">Catalase</fullName>
            <ecNumber evidence="3 10 13">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSTA_002370</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 13">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 13"/>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487825.1">
        <property type="nucleotide sequence ID" value="XM_002487780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MT74"/>
    <dbReference type="STRING" id="441959.B8MT74"/>
    <dbReference type="GeneID" id="8102848"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_002370"/>
    <dbReference type="eggNOG" id="KOG0047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010645_3_0_1"/>
    <dbReference type="InParanoid" id="B8MT74"/>
    <dbReference type="OMA" id="YGDWSNI"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="PhylomeDB" id="B8MT74"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000003">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821:SF3">
        <property type="entry name" value="CATALASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18011">
        <property type="entry name" value="Catalase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002875357" description="Catalase" evidence="15">
        <location>
            <begin position="20"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="Catalase core" evidence="16">
        <location>
            <begin position="68"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EED12171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="733" mass="79731" checksum="B95C22BD39589FDA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTQ6</accession>
    <name>B8MTQ6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase, short-chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_005700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488195.1">
        <property type="nucleotide sequence ID" value="XM_002488150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTQ6"/>
    <dbReference type="STRING" id="441959.B8MTQ6"/>
    <dbReference type="GeneID" id="8105544"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_005700"/>
    <dbReference type="eggNOG" id="KOG1209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="InParanoid" id="B8MTQ6"/>
    <dbReference type="OMA" id="RFHANEG"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="PhylomeDB" id="B8MTQ6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED12541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="282" mass="29840" checksum="11210C14CC1E9046" modified="2009-03-03" version="1">MPLKSILVTGCSGGGIGSAIALLLARKGHHVFATARNTSKIPEELTSLSNVTVLSLDVTSMPSVKEAAKAVSESGHGLDVLVNNAGIGYVTPILDMDIEEAKRVHDTNLWGSIRMIQAFKDLLIASHGRIVNIISIGALLNLPWHAAYCSAKIAMANISETLRLELAPFGVNVVAVMAGTVATKFDANCTEFTLPSGSLYASIKDYIAGWVTGTAKPPGGSVDEFAQLVHEDIVGKGRNGVVYRGENSGMTAFVVNWFPRWIVDKLLVSQNSGLPALAKIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8MU01</accession>
    <name>B8MU01_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">U5 snRNP complex subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_006540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488288.1">
        <property type="nucleotide sequence ID" value="XM_002488243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MU01"/>
    <dbReference type="STRING" id="441959.B8MU01"/>
    <dbReference type="GeneID" id="8105339"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_006540"/>
    <dbReference type="eggNOG" id="KOG0265">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_2_1"/>
    <dbReference type="InParanoid" id="B8MU01"/>
    <dbReference type="OMA" id="IWDIRPY"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="PhylomeDB" id="B8MU01"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052234">
        <property type="entry name" value="U5_snRNP_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="61"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="104"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="146"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="195"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="230"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="291"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="322"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED12634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="358" mass="39136" checksum="D24FAB92992AEE5E" modified="2009-03-03" version="1">MSGEKRPASESFNPTSQLVVKRQKSNSDLKSNAVTLRSGQNGTVVQAIPRTSGLAAPIMELTGHSGEIFATRFDPTAQSIASGSMDRTIMLWRTYEQCENYGVLTGHKGAVLDLQWSRDSRFIFSASADMTIASWDIETGQRIRRHMGHEEAINCVDISKRGQEVLVSGSDDGYIGIWDPRQKAALDFIETDFPITAVALSEAGNEIFTGGIDNDIKVWDVRKKAVVYSLIGHNDTITSLQISPDSQTLLSNSHDSTVRTWDIRPFAPADRSVRTFDGAPVGLEKNLIRASWDPKGQKIAAGSGDRTVVVWDAKSGKLLYKLPGHKGTVNDVRFSPNDEPIIVSGSSDRNIMLGELGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MU59</accession>
    <name>B8MU59_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Endochitinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_109570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GPI-anchored chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods). Required to reshape the cell wall at the sites where cell wall remodeling and/or cell wall maturation actively take place such as sites of conidia formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488533.1">
        <property type="nucleotide sequence ID" value="XM_002488488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MU59"/>
    <dbReference type="FunCoup" id="B8MU59">
        <property type="interactions" value="173"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MU59"/>
    <dbReference type="GeneID" id="8107189"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109570"/>
    <dbReference type="eggNOG" id="KOG4701">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007818_6_1_1"/>
    <dbReference type="InParanoid" id="B8MU59"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="PhylomeDB" id="B8MU59"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02877">
        <property type="entry name" value="GH18_hevamine_XipI_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045321">
        <property type="entry name" value="Cts1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002875376" evidence="7">
        <location>
            <begin position="20"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="8">
        <location>
            <begin position="31"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED11777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="386" mass="41580" checksum="0064D669A613733D" modified="2009-03-03" version="1">MQISTVLINFALMASSTMGASHRLQVRGPGGEVVVYWGQNAAAASENNDLSNYCTAGSGINIVVLSFLYEYGNGITIPSGVIGNDCSISTSGEGTNCDALAKQIATCQSNGVKVILSLGGAVGAYSLTSQAEAETIGQNLWDAYGKTSGGSVPRPFGATFVNGWDFDIEANCGNQYYQYMIAKLRSNFVSDPSNTYYITGAPQCPIPEPNMGEIIRAAQFDYLWVQFYNNGYCSYPNTLNYKDWVSYVSGTPSANAKIFIGVPASELGSTGTETGAAYYQCPSALASTVSSFHDSSKWGGIMMWNAAFSDKNVIDGCNYAQQAQSILTTGSPLVSMPVDYLHMRRNEGIAWDAAFAEGHAKYHLSRIYILFDIHQFPLIIGQMLCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUX4</accession>
    <name>B8MUX4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_109210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488498.1">
        <property type="nucleotide sequence ID" value="XM_002488453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUX4"/>
    <dbReference type="GeneID" id="8107153"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109210"/>
    <dbReference type="HOGENOM" id="CLU_1205474_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUX4"/>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="230" mass="24896" checksum="5EEA47660B6D8381" modified="2009-03-03" version="1">MADVIRIVKSTEEVVGKNNHVLKSLELKMTRVLKDAMGRSHTTTSTISLDTILSQVDIERMLTNSGSTLNLTLTDMSDDSASIIVVPDSLSLVDCASARIKFPSNATKDQPNIIFPRVDPQNDIDSVLDYSPPSSTTAETPAGEADGITVESHFGLDDNVSNTSKHADEKNITRLTNTIAQQIIEHLRLSKSSSNSYSKKRMPGSRLIDYGEASDPLSTTALNALLSMST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MV13</accession>
    <name>B8MV13_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_110820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488659.1">
        <property type="nucleotide sequence ID" value="XM_002488614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MV13"/>
    <dbReference type="STRING" id="441959.B8MV13"/>
    <dbReference type="GeneID" id="8101454"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_110820"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_3_1"/>
    <dbReference type="InParanoid" id="B8MV13"/>
    <dbReference type="OMA" id="YMYLLLG"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="PhylomeDB" id="B8MV13"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000319">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF30">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04702)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED11903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="59298" checksum="FEFDB20EC0DB6AF5" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8MV91</accession>
    <name>B8MV91_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_008430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962662">
        <property type="protein sequence ID" value="EED11547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488728.1">
        <property type="nucleotide sequence ID" value="XM_002488683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MV91"/>
    <dbReference type="STRING" id="441959.B8MV91"/>
    <dbReference type="GeneID" id="8108577"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_008430"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_854081_0_0_1"/>
    <dbReference type="InParanoid" id="B8MV91"/>
    <dbReference type="OrthoDB" id="4345481at2759"/>
    <dbReference type="PhylomeDB" id="B8MV91"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="3">
        <location>
            <begin position="92"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="GAG-pre-integrase" evidence="2">
        <location>
            <begin position="203"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED11547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="326" mass="36757" checksum="413E7E925848CC35" modified="2009-03-03" version="1" fragment="single">GHYERDCHIRQQQLDSGAAKLDRGRAYLVQQPSSLQPPPQPQPLLAPPPPQANFASSQSQSSESNAYSYPSHLLTRASYINSEIRQQDYLSWILDSGATQHFCNSKLDLKDYKHFLEPREIYLGDNTTIYAEGSGTQHLQVGPNILVLNVWFVPKLAENLLSLQLLDRAGYSTLIENGIVYIRQQGDSNSAWFQLANSKHGDLYRMHISPSSLVNAPRALRTREFSTLRLWHNRLGHRKFRSVEDLMNLSVPRQLPTCTACLQGKMKADSTFLCLNVAASHSTACMPSLSPWTVSPLVDLSICYYWSMITLAMHGVILPQARMFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTD0</accession>
    <name>B8LTD0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">D-amino-acid oxidase</fullName>
            <ecNumber evidence="8">1.4.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_064740</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-alpha-amino acid + O2 + H2O = a 2-oxocarboxylate + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21816"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="EC" id="1.4.3.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:21817"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.3" evidence="8"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340395.1">
        <property type="nucleotide sequence ID" value="XM_002340354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTD0"/>
    <dbReference type="STRING" id="441959.B8LTD0"/>
    <dbReference type="GeneID" id="8104195"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_064740"/>
    <dbReference type="eggNOG" id="KOG3923">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034311_1_0_1"/>
    <dbReference type="InParanoid" id="B8LTD0"/>
    <dbReference type="OMA" id="WERRTWI"/>
    <dbReference type="OrthoDB" id="409956at2759"/>
    <dbReference type="PhylomeDB" id="B8LTD0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000018">
        <property type="entry name" value="D-amino acid oxidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF16">
        <property type="entry name" value="D-AMINO ACID OXIDASE (AFU_ORTHOLOGUE AFUA_5G11290)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877373" description="D-amino-acid oxidase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="12">
        <location>
            <begin position="6"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="46"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED23008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="364" mass="39711" checksum="840A6A787BF83F7B" modified="2009-03-03" version="1">MASNNIVVLGAGVIGLTTAMLLSRDPENKVTVAAKHMPGDYDIEYTSPWAGANYLPVGQEDNKIGQWEKLTWPHLQELAKNCPEAGIHFQDTLVYNRKKDQESTTGKWFAELIKPNPWYGKVVPNYRELPQSELSPGVDNANSFTSVCINTALYLPWLVGQCRQNGVIFKRAIVKHISEAANLHHSGSKADVVVNCTGLSSRSLGGVMDTTLLPARGQIILVRNDPGVMASISGTDDGDDEATYIMTRAVGGGTILGGSYQKNNWDPNPDPNLAVRIMKRCIELCPSLVGEGQGIEGLSIIRHGVGLRPLRESGPRIERERSDDFWIVHNYGHAGYGYQTSYGSAEDAVGLVKQALQQAKKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTQ2</accession>
    <name>B8LTQ2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">4-hydroxybenzoate polyprenyltransferase, mitochondrial</fullName>
            <shortName evidence="16">4-HB polyprenyltransferase</shortName>
            <ecNumber evidence="16">2.5.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Para-hydroxybenzoate--polyprenyltransferase</fullName>
            <shortName evidence="16">PHB:PPT</shortName>
            <shortName evidence="16">PHB:polyprenyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSTA_070540</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 16">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>an all-trans-polyprenyl diphosphate + 4-hydroxybenzoate = a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44504"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="16">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Mitochondrion inner membrane</location>
            <topology evidence="2 16">Multi-pass membrane protein</topology>
            <orientation evidence="2 16">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="16"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341031.1">
        <property type="nucleotide sequence ID" value="XM_002340990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTQ2"/>
    <dbReference type="FunCoup" id="B8LTQ2">
        <property type="interactions" value="343"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LTQ2"/>
    <dbReference type="GeneID" id="8101204"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_070540"/>
    <dbReference type="eggNOG" id="KOG0911">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034879_2_1_1"/>
    <dbReference type="InParanoid" id="B8LTQ2"/>
    <dbReference type="OMA" id="ISPRNAV"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="PhylomeDB" id="B8LTQ2"/>
    <dbReference type="UniPathway" id="UPA00213"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000003">
        <property type="entry name" value="4-hydroxybenzoate polyprenyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000005">
        <property type="entry name" value="Glutaredoxin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00365">
        <property type="entry name" value="Grx4 family monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01474">
        <property type="entry name" value="ubiA_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="16" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="16" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="17">
        <location>
            <begin position="471"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00058997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EED23644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="568" mass="62267" checksum="441CCCC7DBEFCF31" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUC8</accession>
    <name>B8LUC8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentafunctional AROM polypeptide, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_071040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341088.1">
        <property type="nucleotide sequence ID" value="XM_002341047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUC8"/>
    <dbReference type="STRING" id="441959.B8LUC8"/>
    <dbReference type="GeneID" id="8107600"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_071040"/>
    <dbReference type="eggNOG" id="KOG0692">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009960_0_0_1"/>
    <dbReference type="InParanoid" id="B8LUC8"/>
    <dbReference type="OMA" id="AINAHCV"/>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="PhylomeDB" id="B8LUC8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000135">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050068">
        <property type="entry name" value="MurA_subfamily"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01093">
        <property type="entry name" value="aroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43783">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43783:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED23701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="672" mass="74308" checksum="61D8455E6417C56A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUK8</accession>
    <name>B8LUK8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.157</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TSR3</name>
        <name evidence="10" type="ORF">TSTA_072560</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63300"/>
            <dbReference type="Rhea" id="RHEA-COMP:13852"/>
            <dbReference type="Rhea" id="RHEA-COMP:16309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
            <dbReference type="EC" id="2.5.1.157"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.157" evidence="6"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341252.1">
        <property type="nucleotide sequence ID" value="XM_002341211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUK8"/>
    <dbReference type="FunCoup" id="B8LUK8">
        <property type="interactions" value="798"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LUK8"/>
    <dbReference type="GeneID" id="8100208"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_072560"/>
    <dbReference type="eggNOG" id="KOG3154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035060_0_2_1"/>
    <dbReference type="InParanoid" id="B8LUK8"/>
    <dbReference type="OMA" id="CSWARTQ"/>
    <dbReference type="OrthoDB" id="10262062at2759"/>
    <dbReference type="PhylomeDB" id="B8LUK8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:rRNA small subunit aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002621">
        <property type="entry name" value="PRK02287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase L inhibitor RLI-like possible metal-binding" evidence="9">
        <location>
            <begin position="46"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="8">
        <location>
            <begin position="83"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="218"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED23865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="391" mass="43977" checksum="9E90206AA27FEA25" modified="2009-03-03" version="1">MVRHKKDNFARGGKKSGPPRHRPSPRAGTQDENDTTEGGATRPPFKAACWDLGHCDPKRCSGKRLMNFGLMRELQIGHKHSGVVISPNAKRVLSPADRDLLEQYGAAVVECSWVRVKEVPWSRIGGKCERLLPYLIAANSVNYGRPWRLNCVEALAACFYICGHEDWAEEVLKHFSYGEAFININSQLLKRYAACSNEEDIKRTEEEWLNKIEREYNESRAEREAGGADDMWHRGNTNRLEIPDSDDNQDEDEDGEGEEEEEEEDKDPFAISDDSDDEEEMAEIRRKILNSKSFQNPTSESSSQEPQPQPASSTKTPSQSQNKKQLPIDSDSESGSAEVSDDEDDEAFDNIINATPVTDRTGILAAKKQRKVNDSLTASFSRTVISAPKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUN1</accession>
    <name>B8LUN1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_072780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <source>
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        </source>
    </evidence>
    <sequence length="454" mass="51169" checksum="1CD68F48E6F20CCD" modified="2009-03-03" version="1">MGDSLPYTCNACLVAFRTSDAQREHMRRDWHLYNVKRRVASLPPVSQEVFTEKVLTARVTTSAAAAKASFEKTCEACQKSFYSENSYQNHLQSSKHKLREKALKKKGGLADDTSSVMSSTFSLGDPINKSVAGDNESTVSNVTEKLKNTAIKEAENEDEDMEEKDEEEKTEEYSSTKCLFCTEEAGDLQANVEHMFKVHGMFIPEKDYLADLDGLIRYLHAKISENHECLLCHAIRTTAAGIRTHMRDKSHCMIAFETEEEQVEIGQFYDFRSTYSDDEEEDEDITDDAGGVPITSSDADEAGWETDDSSVDSDPQQKPFRGSQPIYQTDYELHLPSGRSVGHRSLAKYYRQNLHSYPSLEERAAARQLAIENGTADKDGEGETTTIKRNEHKAIISRANGGLGLVGASAQQRTEALEIERRERTRAQREERKITAKVNRQANSQKHFRDPLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8LV87</accession>
    <name>B8LV87_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_065900</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340524.1">
        <property type="nucleotide sequence ID" value="XM_002340483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LV87"/>
    <dbReference type="STRING" id="441959.B8LV87"/>
    <dbReference type="GeneID" id="8101206"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_065900"/>
    <dbReference type="eggNOG" id="ENOG502QTBT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_8_2_1"/>
    <dbReference type="InParanoid" id="B8LV87"/>
    <dbReference type="OMA" id="IFRTGLF"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="PhylomeDB" id="B8LV87"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051915">
        <property type="entry name" value="Cellulose_Degrad_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30620:SF16">
        <property type="entry name" value="LYSOSOMAL BETA GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30620">
        <property type="entry name" value="PERIPLASMIC BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="10">
        <location>
            <begin position="62"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 3 C-terminal" evidence="11">
        <location>
            <begin position="442"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED23137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="595" mass="66725" checksum="47331FC8B5BCCB03" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8LW80</accession>
    <name>B8LW80_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7603 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_074870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341495.1">
        <property type="nucleotide sequence ID" value="XM_002341454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LW80"/>
    <dbReference type="STRING" id="441959.B8LW80"/>
    <dbReference type="GeneID" id="8102321"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_074870"/>
    <dbReference type="eggNOG" id="ENOG502QU2M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002590_0_0_1"/>
    <dbReference type="InParanoid" id="B8LW80"/>
    <dbReference type="OMA" id="DQKWQCE"/>
    <dbReference type="OrthoDB" id="5395440at2759"/>
    <dbReference type="PhylomeDB" id="B8LW80"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056023">
        <property type="entry name" value="DUF7603"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24554">
        <property type="entry name" value="DUF7603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7603" evidence="3">
        <location>
            <begin position="694"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="561"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="423"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="735"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="812"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="902"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="587"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED24108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="967" mass="107382" checksum="78730DBF70859FAF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWD1</accession>
    <name>B8LWD1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Formin binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_076130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341629.1">
        <property type="nucleotide sequence ID" value="XM_002341588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWD1"/>
    <dbReference type="STRING" id="441959.B8LWD1"/>
    <dbReference type="GeneID" id="8106174"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_076130"/>
    <dbReference type="eggNOG" id="KOG0150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051534_0_0_1"/>
    <dbReference type="InParanoid" id="B8LWD1"/>
    <dbReference type="OMA" id="KSAPRYW"/>
    <dbReference type="OrthoDB" id="191651at2759"/>
    <dbReference type="PhylomeDB" id="B8LWD1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040023">
        <property type="entry name" value="WBP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173:SF10">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="48"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="140"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED24242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="286" mass="32526" checksum="2BCAB0B7BFBB5D02" modified="2009-03-03" version="1">MAEYWKSTPKYWCKHCQIYVRDTPFEKTQHEATGKHQGNLKRFLRDIHRNKEREEKESQRTKNEVERLRNLVSGKPAGDATRNRPAATTSTTAPRQVTAEDRKKQIAQLAEMGVAVPEEYRREMALAGDWQTISERRITPVEPSKEEAESTKLNIGVRKRKLENEEDEEEAQMIAKPTHRGWGNTTRDYPGTTEDEDDDLDALLMKTTTVKEKKDPDPKTVLQSIKAGEQAESGDVEKTEKDPDGSGPSTILKKEEPDTGDSLETPSLPVGDVPVFKRRKNKASKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWE3</accession>
    <name>B8LWE3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Anthranilate phosphoribosyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_076240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341641.1">
        <property type="nucleotide sequence ID" value="XM_002341600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWE3"/>
    <dbReference type="FunCoup" id="B8LWE3">
        <property type="interactions" value="308"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LWE3"/>
    <dbReference type="GeneID" id="8102507"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_076240"/>
    <dbReference type="eggNOG" id="KOG1438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034315_2_0_1"/>
    <dbReference type="InParanoid" id="B8LWE3"/>
    <dbReference type="OMA" id="GPMTNPA"/>
    <dbReference type="OrthoDB" id="427800at2759"/>
    <dbReference type="PhylomeDB" id="B8LWE3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1030.10:FF:000008">
        <property type="entry name" value="Anthranilate phosphoribosyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285:SF2">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 3" evidence="4">
        <location>
            <begin position="107"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED24254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="434" mass="47266" checksum="2EE0D52282E0CEC5" modified="2009-03-03" version="1">MAETAKPEPVSISPLLQRLAYPDVAKVQVSAEEIAAAFALIFEDRLSIIQTTALLTLLHSTGLDRDSKVIALCSNRMREAASTVDRPALRAVVKSRGRREGEYRGGLCDIVGTGGDSHSTFNVSTTSSIIASALLMIAKHGNRSQTSFSGSADVLNCILPVPPKISAIQANDIAKVLEETNYTFLFAPNFHQGMKYADPVRRGLGIRTIFNLMGPLANPVDWALEARVVGVAYQSLGPVFIEALRLGGSKKALVICGEEDMDEISCAGPTNCWRLSEYPNPTYKDDAANNDDDDEADEDDDDEDSVPRTLTKLDIFQLHPKDFGFPTHPITDVYTKKLPKQNAAKLMSILRNELDPEDPLMHFILMNTAALLVTSGICEAETSNMGPGDDGKVITERGPGGGRWKEGVRRARYAITSGQALRSLEQFIEATNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWJ1</accession>
    <name>B8LWJ1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BZIP transcription factor CpcA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_076680</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the bZIP family. GCN4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341689.1">
        <property type="nucleotide sequence ID" value="XM_002341648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWJ1"/>
    <dbReference type="FunCoup" id="B8LWJ1">
        <property type="interactions" value="3043"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LWJ1"/>
    <dbReference type="GeneID" id="8105636"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_076680"/>
    <dbReference type="eggNOG" id="KOG0837">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029566_1_1_1"/>
    <dbReference type="InParanoid" id="B8LWJ1"/>
    <dbReference type="OMA" id="GPGHEEW"/>
    <dbReference type="OrthoDB" id="5419235at2759"/>
    <dbReference type="PhylomeDB" id="B8LWJ1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12193">
        <property type="entry name" value="bZIP_GCN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001491">
        <property type="entry name" value="Cross-pathway control protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="10">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="124"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED24302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="241" mass="26135" checksum="78C87E08E10E9D30" modified="2009-03-03" version="1">MSSSNIAQDFSLDLFDLPTQSPLLDDLTSPISSMMASPLLDEFAYMTSSSATVPPGTVSPKDLMSGPPSSFSTELGTPQSAFDSPAGLAFAQFTSPVYAADSDLPADSNDWASLFPDSNDMSGENFDMPFSTFAQEKTSKSRPSTANMSAASPVSSTDGDVMSQKARNKRNLPEPKYDPSDPVAVKRARNTMAARKSRRRKLEKQEQMEDRIRELEAMLAKSQKDVEYWKALAGTAMSSDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWK1</accession>
    <name>B8LWK1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sit4-associated protein (Sap185), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_077580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPS family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002341744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWK1"/>
    <dbReference type="FunCoup" id="B8LWK1">
        <property type="interactions" value="1030"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LWK1"/>
    <dbReference type="GeneID" id="8101956"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_077580"/>
    <dbReference type="eggNOG" id="KOG2073">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8LWK1"/>
    <dbReference type="OrthoDB" id="295029at2759"/>
    <dbReference type="PhylomeDB" id="B8LWK1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="InterPro" id="IPR007587">
        <property type="entry name" value="SAPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634:SF8">
        <property type="entry name" value="FIERY MOUNTAIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634">
        <property type="entry name" value="SIT4 YEAST -ASSOCIATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04499">
        <property type="entry name" value="SAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="450"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="592"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="863"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="937"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1092"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="450"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="493"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="602"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="863"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="873"/>
            <end position="887"/>
        </location>
    </feature>
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        <location>
            <begin position="950"/>
            <end position="960"/>
        </location>
    </feature>
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        <location>
            <begin position="1040"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1105"/>
            <end position="1120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED24398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1135" mass="125021" checksum="48A2EE31609D4B4B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWZ4</accession>
    <name>B8LWZ4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dihydrodipicolinate synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_079820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002341973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWZ4"/>
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    <dbReference type="eggNOG" id="ENOG502QWNS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_0_2_1"/>
    <dbReference type="InParanoid" id="B8LWZ4"/>
    <dbReference type="OMA" id="MVPVCAG"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="PhylomeDB" id="B8LWZ4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF66">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="3">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED24627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="327" mass="35301" checksum="2E15320C3CAC40B5" modified="2009-03-03" version="1">MVQRALRPGVYVPLPTFFDENQEIDYFSYKEHLLNLATKGMVPVCAGSLGEAVHLSFDERIALIQFIRVTLDEADLTSTPIVVGVGGLSTRETIELARAAAKSGADAGMVIPPAYYAASLSADAQQVIQYYIDICEGSPIPLLLYNFPTNAGGQDMPSAVISEIIKKAPNLCGVKLTCGDSIGKLVRLNAEIQGDPNINGARPFPFLLLDGLIADLAPWVQCGGHGTVSGIPNFAPTASTRLWELLNTHPLTPEEATECARLQAILSNADVVAVPGGIRAMKYALHKMHGYGMAPRKPLLPLKESEGQDFMNALRELIDLEAEYIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXS6</accession>
    <name>B8LXS6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="28">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">TSTA_080160</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22 30">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002342048.1">
        <property type="nucleotide sequence ID" value="XM_002342007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXS6"/>
    <dbReference type="STRING" id="441959.B8LXS6"/>
    <dbReference type="GeneID" id="8109476"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_080160"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001650_5_0_1"/>
    <dbReference type="InParanoid" id="B8LXS6"/>
    <dbReference type="OMA" id="FERDECI"/>
    <dbReference type="OrthoDB" id="4501190at2759"/>
    <dbReference type="PhylomeDB" id="B8LXS6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="20" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <keyword evidence="24" id="KW-0862">Zinc</keyword>
    <keyword evidence="24" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="26">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="27">
        <location>
            <begin position="484"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="193"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="769"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="25">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="25">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="792"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="808"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="818"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="850"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="EED24661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1257" mass="144179" checksum="723EA99B19374D6F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXY9</accession>
    <name>B8LXY9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C6 and C2H2 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_062910</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340191.1">
        <property type="nucleotide sequence ID" value="XM_002340150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXY9"/>
    <dbReference type="STRING" id="441959.B8LXY9"/>
    <dbReference type="GeneID" id="8106668"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_062910"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037785_0_0_1"/>
    <dbReference type="InParanoid" id="B8LXY9"/>
    <dbReference type="OMA" id="QSVVMMG"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="PhylomeDB" id="B8LXY9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED22804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="424" mass="48557" checksum="E1D72278309C4AEA" modified="2009-03-03" version="1">MSARETSFQCHFPGCGLRYRRKEHLTRHARRHFQPESFECPFCDRVFARNDTLRQHVRIRHKNRELHSGRAIRACNYCRSRRSRCDGKVPCETCLGKGIQCSFARSSPRPKVEQQRSPTISTTPGTLGEPNYQYTAYASSNLIRNSDSIERSPCRMLPYIQAYFEKFHPNWPFLHRATFDVDREPTLLVQSVVMMGLWLTGENNAQLAAMDLHSELTLLIHQQRDKWDVSNQHEMSPGSLSPWPMATYQGILLHITFALIKGNGKQLDLQLTHQLSEIPSQLLVALVDCCRKREMLFYPSMLAQFNADSLPGVYIWLGIEEAKRFALALYKVCRCCRVHDTLLSYGGSMDSHLQIKLCAQVSSLLSLADLQFALPDSDELWHASSNLASRVADNACAYWEKNAEENWICQAARLLQTPGGFNWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYY5</accession>
    <name>B8LYY5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytosine deaminase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_069140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340880.1">
        <property type="nucleotide sequence ID" value="XM_002340839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYY5"/>
    <dbReference type="STRING" id="441959.B8LYY5"/>
    <dbReference type="GeneID" id="8101224"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_069140"/>
    <dbReference type="eggNOG" id="KOG1018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025810_5_1_1"/>
    <dbReference type="InParanoid" id="B8LYY5"/>
    <dbReference type="OMA" id="GDHPENP"/>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="PhylomeDB" id="B8LYY5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF179">
        <property type="entry name" value="TRNA(ADENINE(34)) DEAMINASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="154" mass="16576" checksum="904E82F8B81713E2" modified="2009-03-03" version="1">MISLSDINYLRRCVDLAREAVDAGDAPFGSILVNAAGEILQEARNRVTTEEDITLHPEFTLVIWAQKHLSPTERATTTVYTSGEHCPMCASAHAYADLGRIVYVSSSAQLVQWRREFGVKSGPVAPLPIGQVAPGLVVDGPVPGLDEEFAIDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYY9</accession>
    <name>B8LYY9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pogo transposable element, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_069180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340884.1">
        <property type="nucleotide sequence ID" value="XM_002340843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYY9"/>
    <dbReference type="GeneID" id="8101252"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_069180"/>
    <dbReference type="eggNOG" id="ENOG502S2ZX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_4_0_1"/>
    <dbReference type="InParanoid" id="B8LYY9"/>
    <dbReference type="OMA" id="HNPTEAP"/>
    <dbReference type="OrthoDB" id="4217853at2759"/>
    <dbReference type="PhylomeDB" id="B8LYY9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="60"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED23497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="548" mass="62907" checksum="EF2854E56B3067D1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZF7</accession>
    <name>B8LZF7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine-threonine protein kinase 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_089470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STK19 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478673.1">
        <property type="nucleotide sequence ID" value="XM_002478628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZF7"/>
    <dbReference type="GeneID" id="8104914"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_089470"/>
    <dbReference type="eggNOG" id="ENOG502S7IU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036328_0_0_1"/>
    <dbReference type="InParanoid" id="B8LZF7"/>
    <dbReference type="OMA" id="MNFRWAL"/>
    <dbReference type="OrthoDB" id="3980126at2759"/>
    <dbReference type="PhylomeDB" id="B8LZF7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046579">
        <property type="term" value="P:positive regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018865">
        <property type="entry name" value="STK19-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15243">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15243:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10494">
        <property type="entry name" value="Stk19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00093458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="41191" checksum="531AD08215700E64" modified="2009-03-03" version="1">MPLRITSAPVSGIKKRKSVATPRNRAFPFASHARSKPAVRGNAQTTTKSFELHVEEEADGFVSDSEPLPDVGDSRYLTETVKLSGVIQAMQHVKNSMFEELPERRAGMNSTRIAEVLNIRRSLPPLVSVAHLHTVLQSPTQVEREIVSLVQSGQLKRLIVPGRGNSAAGLGDCLVMTSDLHDLVQASSDLDQALKDRFLGILDQMSNTSAIPSLAFSREESVALVRAGFLVSASSLSKDTVNLTSVRAYSTDADDTKPNSVQSRAPAFFLSLPNTGPYLRLLSAGRSHLLTLLKQSKYHEAPLTLLRDRWDGAVESNRNFSVAKRIRGEFSGVLPGRTKKWKEFNGMSFRWILEEALGAGLVEIFDTGSVGPGIRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZH1</accession>
    <name>B8LZH1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA repair protein Rad7, protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_089610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478687.1">
        <property type="nucleotide sequence ID" value="XM_002478642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZH1"/>
    <dbReference type="FunCoup" id="B8LZH1">
        <property type="interactions" value="46"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LZH1"/>
    <dbReference type="GeneID" id="8104928"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_089610"/>
    <dbReference type="eggNOG" id="KOG1947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006598_1_0_1"/>
    <dbReference type="InParanoid" id="B8LZH1"/>
    <dbReference type="OMA" id="ACRHISR"/>
    <dbReference type="OrthoDB" id="1924287at2759"/>
    <dbReference type="PhylomeDB" id="B8LZH1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000601">
        <property type="entry name" value="DNA repair protein Rad7, protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056451">
        <property type="entry name" value="Znf_Tbcl_Rhp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF234">
        <property type="entry name" value="RNI-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23550">
        <property type="entry name" value="zf_Tbcl_Rhp7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair protein rhp7 treble clef" evidence="2">
        <location>
            <begin position="115"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED21724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="586" mass="66028" checksum="F641BEB2EFFFF50A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8M036</accession>
    <name>B8M036_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD dependent epimerase/dehydratase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_082010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477931.1">
        <property type="nucleotide sequence ID" value="XM_002477886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M036"/>
    <dbReference type="STRING" id="441959.B8M036"/>
    <dbReference type="GeneID" id="8104839"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_082010"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="InParanoid" id="B8M036"/>
    <dbReference type="OMA" id="NTYNERA"/>
    <dbReference type="OrthoDB" id="4223976at2759"/>
    <dbReference type="PhylomeDB" id="B8M036"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF562">
        <property type="entry name" value="ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED20968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="343" mass="37810" checksum="6E421E7E84DAA77C" modified="2009-03-03" version="1">MSTTLKRPTALQLGERVLVTGANSYLASNIIDLLLSLGYFVRGTIRAEKPWLDEYFTSKYGVGKFESVIVPDVTHKESLVKVLGDISGVMHVASDLSFSADADKVINGVVKATQSVLEAAADQKSVKRFVLTSSSAAATLPKVNVEGNIVDENSWNDEVVKLAWDEKADPRKPAYVYAASKTEGERFAFKWVKEHNPHFTLNTVLPNLAMGPFLSPDFNGSSGQLVVDLLRGNHTIMMAAGPQYYVNVQDVARLHAIALLDPELKSDRLFAFAGTFNWTEIIDILRKLRPNINLPTPPKNEGRDLSVIKPAKRAEELIKTWFDRPGWASLEQTLKEAVDSAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>B8M038</accession>
    <name>B8M038_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 20">DNA topoisomerase 2</fullName>
            <ecNumber evidence="7 20">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">TSTA_083670</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18 20">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 27">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6 20">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 20">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="7 20"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478098.1">
        <property type="nucleotide sequence ID" value="XM_002478053.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B8M038">
        <property type="interactions" value="1165"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M038"/>
    <dbReference type="GeneID" id="8101460"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_083670"/>
    <dbReference type="eggNOG" id="KOG0355">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001935_2_1_1"/>
    <dbReference type="InParanoid" id="B8M038"/>
    <dbReference type="OMA" id="TWTQDFK"/>
    <dbReference type="OrthoDB" id="276498at2759"/>
    <dbReference type="PhylomeDB" id="B8M038"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16930">
        <property type="entry name" value="HATPase_TopII-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03481">
        <property type="entry name" value="TopoIIA_Trans_ScTopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03365">
        <property type="entry name" value="TOPRIM_TopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.268.10:FF:000003">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000003">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.30:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000008">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000004">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.670:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.199.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031660">
        <property type="entry name" value="TOPRIM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034157">
        <property type="entry name" value="TOPRIM_TopoII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16898">
        <property type="entry name" value="TOPRIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
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    </dbReference>
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    <keyword evidence="16 19 20" id="KW-0413">Isomerase</keyword>
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        <location>
            <begin position="556"/>
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        <location>
            <begin position="807"/>
            <end position="1255"/>
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    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="530"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1270"/>
            <end position="1467"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1484"/>
            <end position="1678"/>
        </location>
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        <location>
            <begin position="1121"/>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="25"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="38"/>
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        </location>
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        <location>
            <begin position="60"/>
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        </location>
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            <begin position="86"/>
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        <location>
            <begin position="1347"/>
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        <location>
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            <position position="897"/>
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        <source>
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        </source>
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        <source>
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        <source>
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        </source>
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        <source>
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            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1678" mass="187706" checksum="C764597B049A414B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8M051</accession>
    <name>B8M051_TALSN</name>
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        <submittedName>
            <fullName evidence="4">NAD dependent epimerase/dehydratase, putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">TSTA_083800</name>
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        <name type="synonym">Penicillium stipitatum</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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        <property type="entry name" value="NAD(P)_dehydrat-like"/>
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    </dbReference>
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        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <begin position="16"/>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="339" mass="37562" checksum="2FE1FEC3D0DE5E9B" modified="2009-03-03" version="1">MSTLKRPTTLHPGERVLVTGANSYLASNIIDLLLSLGYHVRGTIRAEKPWLDEYFTSKYGTGKFESVIVPDVTHKESLVKVLGDISGVLHVASDLSFSADADKVINGVVKATQSVLEAAAEQKSVKRFVLTSSSTAATLPKVNVEGNIVDEDSLNDEVVKLAWDEKPDPHKPFYIYGASKTEGERFAFKWVKEHNPHFTLNTVLPNFSMGPFLSPDFNGSSGKLVVDLLRGNYRAMLPQYYVNVQDVARLHAIALLDPELKSDRLFAFAGTFNWTEIIDILRKLRPNGKLPTPPENEGRDLSVIKPAKRAEELIKTWFGRPGWVSLEQTLKEAVDSAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8M060</accession>
    <name>B8M060_TALSN</name>
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        <submittedName>
            <fullName evidence="3">Alpha-1,2-mannosidase, putative subfamily</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">TSTA_083890</name>
    </gene>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED21157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002478075.1"/>
    </dbReference>
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    <dbReference type="STRING" id="441959.B8M060"/>
    <dbReference type="GeneID" id="8101482"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_083890"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003690_4_1_1"/>
    <dbReference type="InParanoid" id="B8M060"/>
    <dbReference type="OMA" id="DFTGNTY"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="PhylomeDB" id="B8M060"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000010">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alpha-1,2-mannosidase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycosyl hydrolase family 92"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF42">
        <property type="entry name" value="PUTATIVE SUBFAMILY (AFU_ORTHOLOGUE AFUA_6G13760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="2">
        <location>
            <begin position="38"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="1">
        <location>
            <begin position="289"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED21157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="784" mass="86374" checksum="18DEE9E08AD0E212" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0H0</accession>
    <name>B8M0H0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_084980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478230.1">
        <property type="nucleotide sequence ID" value="XM_002478185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0H0"/>
    <dbReference type="STRING" id="441959.B8M0H0"/>
    <dbReference type="GeneID" id="8106104"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_084980"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="InParanoid" id="B8M0H0"/>
    <dbReference type="OMA" id="PMINSNE"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="PhylomeDB" id="B8M0H0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF12">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED21267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="276" mass="29476" checksum="A6EFF797F2B3B39A" modified="2009-03-03" version="1">MHGLWEATCFSDRNFAQGSGIGRACAINFAKDGAASVFITDIDLEAAKIVATECKVVATSVNFRVETLQFDITRVESVESATKYMVDKFGRIDYCVNCAGVGIQLQRAVSDADSGEFRRFLQVHVEGTFSLLRSVSAVMVRQELRPNGAIGSGRGATRGSIVTLGSGNSFVAAPEMVQYTTAKHAILGLTKNADNAAHGIRVNCVCPTWVETPMIQKARDGGIDIDTWIRSMVPLGRIATAEEIADAVIFLSSPRSSYVTGCGFIIDGGTLVTAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0S9</accession>
    <name>B8M0S9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_086950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478425.1">
        <property type="nucleotide sequence ID" value="XM_002478380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0S9"/>
    <dbReference type="STRING" id="441959.B8M0S9"/>
    <dbReference type="GeneID" id="8110101"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_086950"/>
    <dbReference type="eggNOG" id="ENOG502SMP1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110344_0_0_1"/>
    <dbReference type="InParanoid" id="B8M0S9"/>
    <dbReference type="OMA" id="YFNAFRA"/>
    <dbReference type="OrthoDB" id="3365267at2759"/>
    <dbReference type="PhylomeDB" id="B8M0S9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20188" checksum="F81644F2BB77D59E" modified="2009-03-03" version="1">MSESLAAFRRHRRDELAKLADQHLQHDLQESDRDALKAATTRVSTWTLIGSAVGIGLGFWVAFRLRSARKSMFEAFKAAEKPVKVVFADGRTESIPDITPFLRPSTLGDFATYFFASAGGLFLGGELGLLGGSASASRSITKDPEMRKRIENAFRKFRADVLRREADELDRDDNLWDKMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0X4</accession>
    <name>B8M0X4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_089930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478717.1">
        <property type="nucleotide sequence ID" value="XM_002478672.1"/>
    </dbReference>
    <dbReference type="GeneID" id="8108081"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_089930"/>
    <dbReference type="HOGENOM" id="CLU_256440_0_0_1"/>
    <dbReference type="InParanoid" id="B8M0X4"/>
    <dbReference type="OMA" id="EARMMAN"/>
    <dbReference type="OrthoDB" id="21416at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="331"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="891"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED21754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1369" mass="155762" checksum="19A883AF8FE0B436" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8M123</accession>
    <name>B8M123_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_090420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
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        <property type="component" value="Unassembled WGS sequence"/>
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            <begin position="232"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED21803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="700" mass="79402" checksum="B0C6A5E59090D2BF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8M195</accession>
    <name>B8M195_TALSN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_082700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M195"/>
    <dbReference type="GeneID" id="8105148"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_082700"/>
    <dbReference type="eggNOG" id="ENOG502SPCI">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1001757_0_0_1"/>
    <dbReference type="InParanoid" id="B8M195"/>
    <dbReference type="OMA" id="MHQIDES"/>
    <dbReference type="OrthoDB" id="4361610at2759"/>
    <dbReference type="PhylomeDB" id="B8M195"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED21037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="278" mass="31899" checksum="40DDEC46D7AF1084" modified="2009-03-03" version="1">MYHIHFGPHQRKVERYLDEATTGTVLTFKGISIGYHTDSRSLDSVLNDLGQVLRLKASEVGQLSSIFQSHCFTDGEQRYWTEESLKHHIKINHPGIATTEHTNSLLWRCFHFYAYHPFPRHDMHQIDESVFQRAVILLAVQGTDFLGTQDGGDYFWRNDTDFFYDADFRRILRSINPAFPEHKSQPTSQISVVNNVMGVLATTQPYAVTLAPSPDLLESAARRLLDSVPGGNRLRYRLYADDFSGLVTLLLQLRICSQKWGMTLHYGEFFQSSKLLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1S2</accession>
    <name>B8M1S2_TALSN</name>
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        <recommendedName>
            <fullName evidence="9">DUF895 domain membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_094050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EED22159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002479077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1S2"/>
    <dbReference type="GeneID" id="8103733"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_094050"/>
    <dbReference type="eggNOG" id="KOG3098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030884_1_2_1"/>
    <dbReference type="InParanoid" id="B8M1S2"/>
    <dbReference type="OMA" id="AYWFIGA"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="PhylomeDB" id="B8M1S2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF59">
        <property type="entry name" value="UNC93-LIKE PROTEIN C922.05C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED22159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="55110" checksum="F55F27B4CA643885" modified="2009-03-03" version="1">MTSTLTAPTSNSEVKDPVLINDNTEKTSDTASATITPTTGEEIVYTTPPKGYRLFGNIVIPAYRSPIVQCIIIAFVHLLVVGMFNVLSALGGGGQVDPTTSNNANTILYSLFAFFALTAGSVVNFLGPKVTLAMGGVGYSLLSASFWSYNHNKNDGFVYFGGATCGVAAAFLWTAEGALIMSLPMEKDKGKYISIFYGLSFFGTVIGAIIPTVENWGVTTAGSANDGTYIALFILMLLGSVVACFISDPSRVVRNDGSRVFVPRNTTFVQELKNVVLAVKREPWIILFFPYSFAGLWYIPYQSNDYNGYYFDLRTRAFGSLWFDFGQFVMAVVMGMMLDWKAVGTRRRRAFVGWTVLFVLLNAVFIGGVFPARRSHRGVPPPGGLIDVDDSRAAGYIILYVFYGFVDGAWQTFAWWVAGCLSNDPLVLSIYSAFYKVFGAMGAAIVFNLDVRKISYQAMFGSYWGLLAGSMLFILVLIFKRVEDSTGVVAEAEVPVEKMIQGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1T1</accession>
    <name>B8M1T1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exoenzymes regulatory protein aepA, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_085400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478272.1">
        <property type="nucleotide sequence ID" value="XM_002478227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1T1"/>
    <dbReference type="STRING" id="441959.B8M1T1"/>
    <dbReference type="GeneID" id="8106146"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_085400"/>
    <dbReference type="eggNOG" id="ENOG502QSHE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009942_3_1_1"/>
    <dbReference type="InParanoid" id="B8M1T1"/>
    <dbReference type="OMA" id="RWWFDHA"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="PhylomeDB" id="B8M1T1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF2">
        <property type="entry name" value="PROTEIN LONG AFTER FAR-RED 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="1">
        <location>
            <begin position="66"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="558" mass="61331" checksum="70266DAEFEBECBE1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B8M317</accession>
    <name>B8M317_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_092350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478956.1">
        <property type="nucleotide sequence ID" value="XM_002478911.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B8M317">
        <property type="interactions" value="1218"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M317"/>
    <dbReference type="GeneID" id="8099417"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_092350"/>
    <dbReference type="eggNOG" id="KOG0168">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0170">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000366_1_1_1"/>
    <dbReference type="InParanoid" id="B8M317"/>
    <dbReference type="OMA" id="AEPLSQF"/>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="PhylomeDB" id="B8M317"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057948">
        <property type="entry name" value="TPR_TRIP12_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25579">
        <property type="entry name" value="TPR_TRIP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="9">
        <location>
            <begin position="1487"/>
            <end position="1841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="721"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1049"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1093"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1174"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1324"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="721"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="741"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="759"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1054"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1116"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1130"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1188"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED21993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1841" mass="203786" checksum="0F9FF410919BEF1C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8M388</accession>
    <name>B8M388_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homeobox and C2H2 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_095060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479223.1">
        <property type="nucleotide sequence ID" value="XM_002479178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M388"/>
    <dbReference type="STRING" id="441959.B8M388"/>
    <dbReference type="GeneID" id="8103836"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_095060"/>
    <dbReference type="eggNOG" id="KOG0773">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008497_1_1_1"/>
    <dbReference type="InParanoid" id="B8M388"/>
    <dbReference type="OMA" id="HLESHNF"/>
    <dbReference type="OrthoDB" id="5399138at2759"/>
    <dbReference type="PhylomeDB" id="B8M388"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="150"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="393"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="152"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="208"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="281"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="359"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED22260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="894" mass="98082" checksum="DBFA75BC383F93A8" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3H5</accession>
    <name>B8M3H5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_095960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479310.1">
        <property type="nucleotide sequence ID" value="XM_002479265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3H5"/>
    <dbReference type="STRING" id="441959.B8M3H5"/>
    <dbReference type="GeneID" id="8105907"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_095960"/>
    <dbReference type="eggNOG" id="KOG0742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_858358_0_0_1"/>
    <dbReference type="InParanoid" id="B8M3H5"/>
    <dbReference type="OrthoDB" id="4187177at2759"/>
    <dbReference type="PhylomeDB" id="B8M3H5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="324" mass="37321" checksum="42458053511C2E67" modified="2009-03-03" version="1">MARTSPPNATDDVTEIEDSPQELYRISQTRLDPGSVEALTPPSSPRVAPSNLITKEELRWLLAEVLRIQSAQPTVDGKDPISNEKTDGQHIARRIIRTSKVEYKTVNEVWDSAKYEYKIVNSTPVPDVHELDEYIFVIRKRSHEQTKELIVYIDTKSPGLRDIKSANLDADRPAIERDLLYHYLDELREYRKRFHSQEATSDDAMLHLSKLVQYLEETYAPVVEQLKLLLESQKITWDLLWALFKPEKQFLRLTRLPGCPDAFGTIIVREKQSEAMNFLKSTDAISIMTERSSVNPPRLCRPHIFTDSIFPHQIDYPVHVAGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3I1</accession>
    <name>B8M3I1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_096020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479316.1">
        <property type="nucleotide sequence ID" value="XM_002479271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3I1"/>
    <dbReference type="STRING" id="441959.B8M3I1"/>
    <dbReference type="GeneID" id="8105913"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_096020"/>
    <dbReference type="HOGENOM" id="CLU_582882_0_0_1"/>
    <dbReference type="InParanoid" id="B8M3I1"/>
    <dbReference type="OrthoDB" id="3786931at2759"/>
    <dbReference type="PhylomeDB" id="B8M3I1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="454" mass="50991" checksum="F789C86C6CFB9C6C" modified="2009-03-03" version="1">MSRLTRKDIKQLEDIEQLAKCFYANVKSPHSDCPELRDRIENLSRHLRASTGNIFHKKGGFQCNAHKGLSAEHTSKIFESLRTDLAEAVNTVKSFEFLFGPDENTTLKRVANTQKNVSRWRDEANQCEACVLSRVATNPSLLRELRTLFLAALPIAPDRPIGRLPPIWGYIDQWIGLSGDKNVLHSISDQRAKIMRHAMYEWKLYETKRSAKGAARPNKHDHFHKSFFGRGHTKPAPQPSTPSTPVTQRARNPLISPTLSQTLSRNAYELSETDFLREFSPSKGFYRAPPGNNYPYSFIDMYSQNPERTPSIPPKQQHQSRPANPATTVSPRLSSTWPSMSDLQSSQSQYSCTRAVSRRTPPPPPKPQPIPRTPERNKVLPPIPNVSPLSIPQDKSPPQNRARPSTSSSRSGVFGGWSSGEDVVGKKVKVKTADKKTRVVDVRATAVKGKHRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3T0</accession>
    <name>B8M3T0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bifunctional fatty acid transporter/acyl-CoA synthetase (FAT1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_038780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481107.1">
        <property type="nucleotide sequence ID" value="XM_002481062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3T0"/>
    <dbReference type="STRING" id="441959.B8M3T0"/>
    <dbReference type="GeneID" id="8107920"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_038780"/>
    <dbReference type="eggNOG" id="KOG1179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_46_3_1"/>
    <dbReference type="InParanoid" id="B8M3T0"/>
    <dbReference type="OMA" id="WRFIRIF"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="PhylomeDB" id="B8M3T0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF20">
        <property type="entry name" value="FATTY ACID TRANSPORTER_ACYL-COA SYNTHETASE (FAT1), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G11360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="74"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED20673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="650" mass="72463" checksum="9A724BD71A9C80E3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4H2</accession>
    <name>B8M4H2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endonuclease III homolog</fullName>
            <ecNumber evidence="8">3.2.2.-</ecNumber>
            <ecNumber evidence="8">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="8">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NTH1</name>
        <name evidence="11" type="ORF">TSTA_024890</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="8"/>
    <dbReference type="EC" id="4.2.99.18" evidence="8"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479601.1">
        <property type="nucleotide sequence ID" value="XM_002479556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4H2"/>
    <dbReference type="FunCoup" id="B8M4H2">
        <property type="interactions" value="499"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M4H2"/>
    <dbReference type="GeneID" id="8106706"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_024890"/>
    <dbReference type="eggNOG" id="KOG1921">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_4_1_1"/>
    <dbReference type="InParanoid" id="B8M4H2"/>
    <dbReference type="OMA" id="WGWHKTQ"/>
    <dbReference type="OrthoDB" id="2099276at2759"/>
    <dbReference type="PhylomeDB" id="B8M4H2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03183">
        <property type="entry name" value="Endonuclease_III_Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030841">
        <property type="entry name" value="NTH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="10">
        <location>
            <begin position="184"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED19167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="448" mass="50368" checksum="9C44B7583F675978" modified="2009-03-03" version="1">MRTSRVSRETAKMVQALSPPRRRTRSSLAASSLRDFSYSENQAAPELSDDSSLSSVKTEDIEDLLERPAKRRRRNVDTPSTTISTVSTSRLVKQEVTIKAETQITTPRSASSKQRRQPAKRIKREDGSIEMQPPSNWETMYNIVKKMRAENPTAPVDTMGCAELHWRSSPPKDQRFQTLVALMLSSQTKDTVTAVAMQRLHTELAQGGGSTNETKPLIKKEEDDDDKDGIKFNHEKKDSTLTVQNMLAVSPERLNELIRTVGFHNNKTKYIKQVANILRDQYNSDIPSTPVELMALPGVGPKMAYLCMSAAWGKHEGIGVDVHVHRITNLWGWHTTKTPEETRIALQSWLPRDKWHEINKLLVGLGQTVCLPVGRRCGECELAGTGLCKSEVKGLAVKMKREVREEVEVKEEGKVKEKAKVKEEAKVSYRDDLFRPETAILAKSVTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4H8</accession>
    <name>B8M4H8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L-fucose-proton symporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_024950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479607.1">
        <property type="nucleotide sequence ID" value="XM_002479562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4H8"/>
    <dbReference type="STRING" id="441959.B8M4H8"/>
    <dbReference type="GeneID" id="8106712"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_024950"/>
    <dbReference type="eggNOG" id="ENOG502QPVD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028452_3_1_1"/>
    <dbReference type="InParanoid" id="B8M4H8"/>
    <dbReference type="OMA" id="CIFPIIF"/>
    <dbReference type="OrthoDB" id="546893at2759"/>
    <dbReference type="PhylomeDB" id="B8M4H8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF5">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED19173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="372" mass="41357" checksum="41B637DB0D2A91C4" modified="2009-03-03" version="1">MTIWNRKITVSDEAVTSAVHLTLRQSLYRIYWVVGAGLSTLETAAQPFLALCGPPRYSEIRLNLGQGVQGVGIFVAPLLASRVFFAHTVNTDQGLKNVQWTYLGVACFVALLIILFFLAPFPEITDADQQALEGAITDSADDVQPLRKQYTLFLGVMSQFCYVGAQVAIAGYHINFAEEAGRSASDASDLLTVAQGLYAFNRFLASFLMMFKPFKPRYMLFVYLLGCIVFSISAMNTSGNTSIALCIIVFCFESCCFATIFSMSLRGLGRHTKRGGSYLVAAISGGMVFPPMMAAVIVRPTKRAYRNGHPYVLAWIFPIYVNLYKREIMDTHRNTEVNVTHTRASEKKIELERARENEPEVTNIENVEGKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5E2</accession>
    <name>B8M5E2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sugar transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_030170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480182.1">
        <property type="nucleotide sequence ID" value="XM_002480137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5E2"/>
    <dbReference type="GeneID" id="8106584"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_030170"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="InParanoid" id="B8M5E2"/>
    <dbReference type="OMA" id="EQSYLCY"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="PhylomeDB" id="B8M5E2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF7">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="9"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED19748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="547" mass="59498" checksum="A8DBD177C2F281AF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8M686</accession>
    <name>B8M686_TALSN</name>
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        <submittedName>
            <fullName evidence="9">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_025770</name>
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    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002479650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M686"/>
    <dbReference type="GeneID" id="8107989"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_025770"/>
    <dbReference type="eggNOG" id="KOG2615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_54_6_1"/>
    <dbReference type="InParanoid" id="B8M686"/>
    <dbReference type="OMA" id="FTWLWQF"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="PhylomeDB" id="B8M686"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
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    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF39">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="66"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
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        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED19261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="574" mass="62206" checksum="118D60CF84F9658F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6B3</accession>
    <name>B8M6B3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_026030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of a tri-snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNUT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479722.1">
        <property type="nucleotide sequence ID" value="XM_002479677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6B3"/>
    <dbReference type="STRING" id="441959.B8M6B3"/>
    <dbReference type="GeneID" id="8108015"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_026030"/>
    <dbReference type="eggNOG" id="KOG3263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075596_0_1_1"/>
    <dbReference type="InParanoid" id="B8M6B3"/>
    <dbReference type="OMA" id="VDSSTMW"/>
    <dbReference type="OrthoDB" id="21368at2759"/>
    <dbReference type="PhylomeDB" id="B8M6B3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013957">
        <property type="entry name" value="SNRNP27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077">
        <property type="entry name" value="U4/U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077:SF1">
        <property type="entry name" value="U4_U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08648">
        <property type="entry name" value="SNRNP27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein" evidence="9">
        <location>
            <begin position="188"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED19288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="242" mass="28495" checksum="F6C2975CCABE2DF6" modified="2009-03-03" version="1">MTEPPMKRARRTDISTMWDTDEKRSRTSHTPEADSRHGSSRPEDSRTSTKDDQRRYRSRSRDRYPRKKDRSWSRDRDRDRDGGKRDSYKDGRGMRDRDRSTSRDRHYNRRGNAKSGRPDRSRSPRNGTRSRDYPARDSKADYRDSKRDGVRRPDQRRTNGASRGGTRDEEDIDPADMMSDIEDSDDIEAMMQKAVGFTKFRSTKNTKVPGNNIYGVRKEKKTEYRQYMNRVGGFNRPLSPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6G0</accession>
    <name>B8M6G0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_026450</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479769.1">
        <property type="nucleotide sequence ID" value="XM_002479724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6G0"/>
    <dbReference type="FunCoup" id="B8M6G0">
        <property type="interactions" value="929"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M6G0"/>
    <dbReference type="GeneID" id="8098926"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_026450"/>
    <dbReference type="eggNOG" id="KOG0417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_13_2_1"/>
    <dbReference type="InParanoid" id="B8M6G0"/>
    <dbReference type="OMA" id="AEPHEDN"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="PhylomeDB" id="B8M6G0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23813">
        <property type="entry name" value="UBCc_UBE2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000020">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED19335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="150" mass="17002" checksum="CC336677DFD1000B" modified="2009-03-03" version="1">MAGLPKRIIKETERLMAEPVPGINAVPHEDNLRYFDVTIHGPAQSPYEGGIFRLELFLPDDYPMTPPKIRFLTKIYHPNIDRLGRICLDVLKNNWSPALQIRTILLSIQALLGAPNPDDPLANDVAQRWKEDEPAAIQTAKEWTRTHAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6H8</accession>
    <name>B8M6H8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_027370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479874.1">
        <property type="nucleotide sequence ID" value="XM_002479829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6H8"/>
    <dbReference type="STRING" id="441959.B8M6H8"/>
    <dbReference type="GeneID" id="8109656"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_027370"/>
    <dbReference type="eggNOG" id="ENOG502S19W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005247_1_1_1"/>
    <dbReference type="InParanoid" id="B8M6H8"/>
    <dbReference type="OMA" id="YVPSEPP"/>
    <dbReference type="OrthoDB" id="410701at2759"/>
    <dbReference type="PhylomeDB" id="B8M6H8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1052" mass="118348" checksum="6B67BCBB6D52227F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6T2</accession>
    <name>B8M6T2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">H/ACA ribonucleoprotein complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleolar protein family A member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_033940</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480586.1">
        <property type="nucleotide sequence ID" value="XM_002480541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6T2"/>
    <dbReference type="FunCoup" id="B8M6T2">
        <property type="interactions" value="1260"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M6T2"/>
    <dbReference type="GeneID" id="8097811"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_033940"/>
    <dbReference type="eggNOG" id="KOG3387">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084513_4_1_1"/>
    <dbReference type="InParanoid" id="B8M6T2"/>
    <dbReference type="OMA" id="IKNQIYA"/>
    <dbReference type="OrthoDB" id="1924699at2759"/>
    <dbReference type="PhylomeDB" id="B8M6T2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000002">
        <property type="entry name" value="NHP2-like protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="11">
        <location>
            <begin position="19"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED20152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="126" mass="13623" checksum="91805C54391D3BA9" modified="2009-03-03" version="1">MSGEPNAAWPVADEALTQNILDVVQQASHYKQLKKGANEATKTLNRGTSELIILAADTSPLAILLHLPLLCEDKNVAYCYVPSKLALGRATGVSRPVIAVSITTNEASDLMPQIRAIKDKVERLMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8M702</accession>
    <name>B8M702_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PDCD2_C domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_034600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480656.1">
        <property type="nucleotide sequence ID" value="XM_002480611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M702"/>
    <dbReference type="FunCoup" id="B8M702">
        <property type="interactions" value="347"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M702"/>
    <dbReference type="GeneID" id="8104302"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_034600"/>
    <dbReference type="eggNOG" id="KOG2061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031771_1_1_1"/>
    <dbReference type="InParanoid" id="B8M702"/>
    <dbReference type="OMA" id="HQVIRYS"/>
    <dbReference type="OrthoDB" id="443682at2759"/>
    <dbReference type="PhylomeDB" id="B8M702"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524:SF1">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Programmed cell death protein 2 C-terminal" evidence="2">
        <location>
            <begin position="284"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED20222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="422" mass="45517" checksum="EF964BB4912608EC" modified="2009-03-03" version="1">MDPYDSDSSGLEDAGDYTETGVLLGYASTEQTDDTISHLGGWPTWLDKNTPPPGDLAKCKVCNNPMLLLLQLNGDLPERFSNDERWLYIFGCPRKACSRKQGSIRALRGIRKMKGQSEIQKKEDSTSNGVSTGATPAPKQDLGSALFGAPSQGGGLSSNSNPFSTSSSPAAQNNNPFAPLPPVSTLAAKPPQNPALNFPETFAAKARISTPETLSEPVTAGPVLPWPDKSVFPAPYTEYYLDADYETLSRPSTPTIPTNTTVENVEEESGGTADVKDAFESSMDKDFLRFSTRLAHNPEQVLRYEFSGTPLLYSGTDAVAKAFPSHQTQGRGVQVAPNAGTNNRIPRCPSCGRERVFELQLVPHAITVLEDGREGIGLGKNDAGMEWGTIILGVCAANCGTVKEGDLVWKEEWVGVQWEETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8J6</accession>
    <name>B8M8J6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_037300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480943.1">
        <property type="nucleotide sequence ID" value="XM_002480898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8J6"/>
    <dbReference type="STRING" id="441959.B8M8J6"/>
    <dbReference type="GeneID" id="8100575"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_037300"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_360226_0_0_1"/>
    <dbReference type="InParanoid" id="B8M8J6"/>
    <dbReference type="OMA" id="DYYEANA"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="PhylomeDB" id="B8M8J6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000191">
        <property type="entry name" value="Methylglyoxal reductase (NADPH-dependent)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016712">
        <property type="entry name" value="Rbsml_bS1m-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11709">
        <property type="entry name" value="Mit_ribos_Mrp51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="461"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="752"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="469"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="759"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED20509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="777" mass="86318" checksum="F5C6EB9F9276C615" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8M924</accession>
    <name>B8M924_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_111550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481311.1">
        <property type="nucleotide sequence ID" value="XM_002481266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M924"/>
    <dbReference type="GeneID" id="8098810"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_111550"/>
    <dbReference type="eggNOG" id="ENOG502SVBM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143030_1_0_1"/>
    <dbReference type="InParanoid" id="B8M924"/>
    <dbReference type="OrthoDB" id="4159828at2759"/>
    <dbReference type="PhylomeDB" id="B8M924"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="139" mass="15248" checksum="963B9180200032CB" modified="2009-03-03" version="1" fragment="single">MSKWHKSTGTFRSPPLKDPLRPNSFPAATIHEKRDVLVRNLLQNLAEAGDILLDSPAVPTTSLYFPDITMVQVEESVLQAGNTAPSSDKIPTCILKVAWPLIKDKTNRSPISTWQRTGALGGTEYGIDLYTLQSISKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9M2</accession>
    <name>B8M9M2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Signal recognition particle 54 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_117970</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. SRP54 binds to the signal sequence of presecretory protein when they emerge from the ribosomes. SRP54 interacts with the scR1 RNA and mediates the association of the resulting SRP-RNC complex with the signal recognition particle receptor (SR) via its alpha subunit SRP101. Both, SRP54 and SRP101, are locked in their GTP bound forms in the SRP-RNC-SR complex, which dissociates upon transferring the signal sequence to the protein-conducting channel (translocon). After signal sequence transfer, SRP54 and SRP101 act as reciprocal GTPase-activating proteins (GAPs), thereby resolving their association.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Fungal signal recognition particle consists of a 7S RNA molecule (scR1) and at least six protein subunits: srp72, srp68, srp54, sec65, srp21 and srp14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The M domain binds the 7SL RNA and the signal sequence of presecretory proteins.</text>
    </comment>
    <comment type="domain">
        <text evidence="13">The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit srp101. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482016.1">
        <property type="nucleotide sequence ID" value="XM_002481971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9M2"/>
    <dbReference type="FunCoup" id="B8M9M2">
        <property type="interactions" value="1012"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M9M2"/>
    <dbReference type="GeneID" id="8102703"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_117970"/>
    <dbReference type="eggNOG" id="KOG0780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_6_1_1"/>
    <dbReference type="InParanoid" id="B8M9M2"/>
    <dbReference type="OMA" id="GMTGQDA"/>
    <dbReference type="OrthoDB" id="10250817at2759"/>
    <dbReference type="PhylomeDB" id="B8M9M2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.30:FF:000003">
        <property type="entry name" value="Signal recognition particle 54 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.140:FF:000001">
        <property type="entry name" value="Signal recognition particle GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006325">
        <property type="entry name" value="SRP54_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01425">
        <property type="entry name" value="SRP54_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="14">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED18024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="534" mass="57332" checksum="104241E353171F74" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9X4</accession>
    <name>B8M9X4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protease S8 tripeptidyl peptidase I, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_118900</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="9">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482118.1">
        <property type="nucleotide sequence ID" value="XM_002482073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9X4"/>
    <dbReference type="STRING" id="441959.B8M9X4"/>
    <dbReference type="MEROPS" id="S53.007"/>
    <dbReference type="GeneID" id="8108564"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_118900"/>
    <dbReference type="eggNOG" id="ENOG502QTN1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013783_4_0_1"/>
    <dbReference type="InParanoid" id="B8M9X4"/>
    <dbReference type="OMA" id="CNEYHVP"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="PhylomeDB" id="B8M9X4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF19">
        <property type="entry name" value="SERINE PROTEASE AORO, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
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    <keyword evidence="6 9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
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            <begin position="1"/>
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        </location>
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            <begin position="19"/>
            <end position="631"/>
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        <location>
            <begin position="215"/>
            <end position="630"/>
        </location>
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        <location>
            <position position="289"/>
        </location>
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            <position position="293"/>
        </location>
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            <position position="548"/>
        </location>
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            <position position="589"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29108"/>
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        <location>
            <position position="590"/>
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            <name>Ca(2+)</name>
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        <location>
            <position position="608"/>
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            <position position="610"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29108"/>
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        <source>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8MA77</accession>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
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    </dbReference>
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        <location>
            <begin position="921"/>
            <end position="930"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50879"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED18406.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="2069" mass="231625" checksum="E48079D96773DBA8" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAB8</accession>
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            <fullName evidence="2">FAD synthase</fullName>
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            <fullName evidence="10">FAD pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
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        <name evidence="15" type="ORF">TSTA_123520</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
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        <reaction evidence="12">
            <text>FMN + ATP + H(+) = FAD + diphosphate</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
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        <property type="protein sequence ID" value="EED18620.1"/>
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        <property type="nucleotide sequence ID" value="XM_002482567.1"/>
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    </dbReference>
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    <dbReference type="OMA" id="EEFVQWS"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
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    </dbReference>
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        <property type="entry name" value="Probable FAD synthetase"/>
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    </dbReference>
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        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
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        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293:SF9">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAPS_reduct"/>
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        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
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    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="14">
        <location>
            <begin position="80"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="14">
        <location>
            <begin position="158"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="239"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED18620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="270" mass="31123" checksum="128D8D21A30A00A9" modified="2009-03-03" version="1">MNQDSSFAQDGSPVNGATKNPSASNVPRTLEEVAIELRTKVFDLLELQTNDELLQNLQKQIRISIEVIEESFRRYRPEELSLSYNGGKDCLVLLVLILVCLPSSTSTFSKFPERLQSIFIIPYDSFPEVEEFVATSTREYFLDLTRYVLPMRPALELYLKERPNIKAIWIGTRRVDPNGGQLTHFDYTDKGWPQFMRIHPVIDWHYAEIWAFIRHLGLDYCPLYDRGFTSLGGVSDTQPNPALAVANDPTQFRPAYELKEDNEERLGRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAC3</accession>
    <name>B8MAC3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_123560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482617.1">
        <property type="nucleotide sequence ID" value="XM_002482572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAC3"/>
    <dbReference type="STRING" id="441959.B8MAC3"/>
    <dbReference type="GeneID" id="8108267"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_123560"/>
    <dbReference type="eggNOG" id="ENOG502SVBM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051551_2_0_1"/>
    <dbReference type="InParanoid" id="B8MAC3"/>
    <dbReference type="OrthoDB" id="4526357at2759"/>
    <dbReference type="PhylomeDB" id="B8MAC3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED18625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="181" mass="19483" checksum="10873D58722B607D" modified="2009-03-03" version="1">MARKGPGTDGPLQTALLESTSAATTRASEGQKIFSPIAAFLDKHRSQTTGLAPHLLRALTALSDDLALVAQRHFSAYISGLEQSTYATITQYAPVKSTPTTHSKAHVKKPMPLVKQPLPDNRLFVRLPADHAARKMEAYAIYSSLWSQLNSNSSALKEVQAIKTGFALCPSSPEALLTLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBB7</accession>
    <name>B8MBB7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_126160</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482898.1">
        <property type="nucleotide sequence ID" value="XM_002482853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBB7"/>
    <dbReference type="STRING" id="441959.B8MBB7"/>
    <dbReference type="GeneID" id="8098128"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_126160"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8MBB7"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="PhylomeDB" id="B8MBB7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00302">
        <property type="entry name" value="cytochrome_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF24">
        <property type="entry name" value="LANOSTEROL 14-ALPHA DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED18906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="547" mass="62415" checksum="5CA9847DA252FAB9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBJ8</accession>
    <name>B8MBJ8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_116520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481854.1">
        <property type="nucleotide sequence ID" value="XM_002481809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBJ8"/>
    <dbReference type="STRING" id="441959.B8MBJ8"/>
    <dbReference type="GeneID" id="8102044"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_116520"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0718">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019611_0_0_1"/>
    <dbReference type="InParanoid" id="B8MBJ8"/>
    <dbReference type="OMA" id="IWYTYHG"/>
    <dbReference type="OrthoDB" id="666364at2759"/>
    <dbReference type="PhylomeDB" id="B8MBJ8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024586">
        <property type="entry name" value="DnaJ-like_C11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052243">
        <property type="entry name" value="Mito_inner_membrane_organizer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11875">
        <property type="entry name" value="DnaJ-like_C11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="33"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED17862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="754" mass="84608" checksum="A264A3571D173042" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBN7</accession>
    <name>B8MBN7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mannan polymerase II complex ANP1 subunit Anp1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_119340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EED18170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482162.1">
        <property type="nucleotide sequence ID" value="XM_002482117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBN7"/>
    <dbReference type="FunCoup" id="B8MBN7">
        <property type="interactions" value="169"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MBN7"/>
    <dbReference type="GeneID" id="8104384"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119340"/>
    <dbReference type="eggNOG" id="ENOG502QVDT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017872_3_0_1"/>
    <dbReference type="InParanoid" id="B8MBN7"/>
    <dbReference type="OMA" id="EHLPMFF"/>
    <dbReference type="OrthoDB" id="204164at2759"/>
    <dbReference type="PhylomeDB" id="B8MBN7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140497">
        <property type="term" value="C:mannan polymerase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000017">
        <property type="entry name" value="Mannan polymerase II complex ANP1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF2">
        <property type="entry name" value="MANNAN POLYMERASE II COMPLEX ANP1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="395"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="395"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="490"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED18170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="514" mass="58434" checksum="F649024E072D1D95" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBY2</accession>
    <name>B8MBY2_TALSN</name>
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        <recommendedName>
            <fullName evidence="3">Wings apart-like protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_121680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WAPL family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482420.1">
        <property type="nucleotide sequence ID" value="XM_002482375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBY2"/>
    <dbReference type="STRING" id="441959.B8MBY2"/>
    <dbReference type="GeneID" id="8098157"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_121680"/>
    <dbReference type="eggNOG" id="ENOG502RZXD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011973_2_0_1"/>
    <dbReference type="InParanoid" id="B8MBY2"/>
    <dbReference type="OMA" id="NNKPKAC"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="PhylomeDB" id="B8MBY2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039874">
        <property type="entry name" value="WAPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022771">
        <property type="entry name" value="WAPL_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100:SF13">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07814">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wings apart-like protein C-terminal" evidence="3">
        <location>
            <begin position="308"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED18428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="771" mass="85533" checksum="A898C4D757DEC4A9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8MC49</accession>
    <name>B8MC49_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nonsense-mediated mRNA decay protein (Nmd5), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_122300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482487.1">
        <property type="nucleotide sequence ID" value="XM_002482442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MC49"/>
    <dbReference type="FunCoup" id="B8MC49">
        <property type="interactions" value="1309"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MC49"/>
    <dbReference type="GeneID" id="8097695"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_122300"/>
    <dbReference type="eggNOG" id="KOG1991">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004196_0_0_1"/>
    <dbReference type="InParanoid" id="B8MC49"/>
    <dbReference type="OMA" id="WVAKTSW"/>
    <dbReference type="OrthoDB" id="760868at2759"/>
    <dbReference type="PhylomeDB" id="B8MC49"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000244">
        <property type="entry name" value="Nonsense-mediated mRNA decay protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF18">
        <property type="entry name" value="D-IMPORTIN 7_RANBP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="24"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="919"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED18495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1041" mass="118103" checksum="DF8301393250B60B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8MC98</accession>
    <name>B8MC98_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial genome maintenance protein MGM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_122750</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGM101 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482536.1">
        <property type="nucleotide sequence ID" value="XM_002482491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MC98"/>
    <dbReference type="FunCoup" id="B8MC98">
        <property type="interactions" value="256"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MC98"/>
    <dbReference type="GeneID" id="8097740"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_122750"/>
    <dbReference type="eggNOG" id="ENOG502RXU4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028692_1_0_1"/>
    <dbReference type="InParanoid" id="B8MC98"/>
    <dbReference type="OMA" id="KIWTRKD"/>
    <dbReference type="OrthoDB" id="17164at2759"/>
    <dbReference type="PhylomeDB" id="B8MC98"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000262">
        <property type="term" value="C:mitochondrial chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009446">
        <property type="entry name" value="Mgm101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404:SF0">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06420">
        <property type="entry name" value="Mgm101p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="25"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED18544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="273" mass="30783" checksum="51189F88B6AE9993" modified="2009-03-03" version="1">MPNMSTRTFQRSYIALESLSQSLRPRRSPVYYTYNPRRLQSSTPAPPAPKQTSPSPPKPPPTTSEAPKSAPTTPNIAKTGLSDKPLDLSPNGYDPSSEKIDWTRSFHGISDQPFAKEVVSILLEEVNPEDVEIKPDGIVYLPEIKYRRILNKAFGPGGWGLVPRSESIVTPKTVTREYALICHGRLVSIARGEQDYFNPDGIPTATEGCKSNALVRCCKDLGVASELWDPRWIRKFKAQYTKEVFVEHVVNKRKSKIWIRKDEEVGYPWKVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCN4</accession>
    <name>B8MCN4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_126440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482928.1">
        <property type="nucleotide sequence ID" value="XM_002482883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCN4"/>
    <dbReference type="STRING" id="441959.B8MCN4"/>
    <dbReference type="GeneID" id="8099071"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_126440"/>
    <dbReference type="eggNOG" id="ENOG502SJ0E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115019_0_0_1"/>
    <dbReference type="InParanoid" id="B8MCN4"/>
    <dbReference type="OMA" id="GIRRWTQ"/>
    <dbReference type="OrthoDB" id="3454835at2759"/>
    <dbReference type="PhylomeDB" id="B8MCN4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="30"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED18936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="152" mass="17838" checksum="28CD19D5A60F9348" modified="2009-03-03" version="1">MTTFTEPEVPEPSGSPKDKYLCLTICGYRKPGMSEEDYRNHMVNISAPMTKGLMVKYGIKRWTQIHNQSSTRALMSHLFDHQMVHVADFDCFSQVVFKDIEHYKRMKQDPWYKKHLIGDHEKFADTQRSMMTIGWVEEFVRDGEVVDDLKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCN7</accession>
    <name>B8MCN7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Map/microtubule affinity-regulating kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_126470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482931.1">
        <property type="nucleotide sequence ID" value="XM_002482886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCN7"/>
    <dbReference type="STRING" id="441959.B8MCN7"/>
    <dbReference type="GeneID" id="8099074"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_126470"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_750431_0_0_1"/>
    <dbReference type="InParanoid" id="B8MCN7"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="B8MCN7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF51">
        <property type="entry name" value="PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="39"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED18939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="369" mass="42384" checksum="D8827F0073BD40EA" modified="2009-03-03" version="1">MKFLALFLKHIAPFVILNIIIISWISGDYWRASQLERYGSMYGVQATGATATVYHYKVRNGTSYAVKLFNKKRAGVSEEEYVNEVRSEVATAGKLRHPRILKVIDLFEERGRWYMVMPYLPTTLFDHSLGNDRLLSPEETECAFQQIVEGVSYLHERGLAHLDLKLSNILLDASGGVKIIDFGQARWFNHSHREKAVQGRFGTPPNVPLEAYQTSAYDPFAADVWAVGIIYCQLVLPSVPWNLGFHSRDEFSIFSPSVQTYGSPRGLDHFQSTCFSKHFSYNLYQDANKFMMTWRRVRKHIETSRATAQGLASKHTRAVNGYIRGTYISQDGDGLMREFGLWRCWVCWSGGYNWTCTKNKRIIFVNQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8MD70</accession>
    <name>B8MD70_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal protein S35, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_114090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481587.1">
        <property type="nucleotide sequence ID" value="XM_002481542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MD70"/>
    <dbReference type="STRING" id="441959.B8MD70"/>
    <dbReference type="GeneID" id="8109171"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_114090"/>
    <dbReference type="eggNOG" id="ENOG502QVMS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049223_1_0_1"/>
    <dbReference type="InParanoid" id="B8MD70"/>
    <dbReference type="OMA" id="KGTGWRY"/>
    <dbReference type="OrthoDB" id="10052321at2759"/>
    <dbReference type="PhylomeDB" id="B8MD70"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021036">
        <property type="entry name" value="Ribosomal_mS45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S35, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12298">
        <property type="entry name" value="Bot1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="301"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED17595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="44431" checksum="81CC8D330EFA5F4C" modified="2009-03-03" version="1">MPPRIKTNRILSSSILPSSSSTLITSHNTSQIQCSARRHLSSSRVAQTRLREQMFDWLNGPGASLKHHIPGSTNYVTALRNRRGGDSEASSTRDNADSEDGYQSKQPFPLNPLFVSEPILSDELSNEIYKRVVVQGKSVRSVSVELRVDMRRVGAVVRLKELEKRMKNEGKSMAVPYARAVHEMVPTTPLAEQGESQPTHESINDLPVHRLTAPQIFYPVSESRQFTRVDAGRVFSAAPALEQGEEATVNVESLIVPQPRRYEKVGKGDEEQQVLLPADARIPHPQLIALERDKISHSMERREYLERYQERLKQSDELEKERKRIAKEKAEKQLTRLQPDNSRFEFRFKDVVVSKETTGPDGRGHVAPGRRYGVPTYDRKKGQVKIPQKVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEF1</accession>
    <name>B8MEF1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_016550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483812.1">
        <property type="nucleotide sequence ID" value="XM_002483767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEF1"/>
    <dbReference type="STRING" id="441959.B8MEF1"/>
    <dbReference type="GeneID" id="8103628"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_016550"/>
    <dbReference type="eggNOG" id="ENOG502S6JE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033726_0_0_1"/>
    <dbReference type="InParanoid" id="B8MEF1"/>
    <dbReference type="OMA" id="WKDPWDP"/>
    <dbReference type="OrthoDB" id="2245989at2759"/>
    <dbReference type="PhylomeDB" id="B8MEF1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF1">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="34026" checksum="7D26AFCFDF041131" modified="2009-03-03" version="1">MEPATQKVNWTRPDVPFKLLDSWIGVTDPKLRKTLQNRLNQRAHRRRQRAQRQQQKQQLVLQGAPKKESKQLLTSTSNPPRSLNHISFCSACGSQKPDIALEQLETLIRFEFANGSPRADLLLGLTQLNIVRALFTNRDILGYKASDMHDDALSAFNQYLNLGPVESQFVAKGTNPELPPSLQPTITQYTIPHHPWLDLIPISKLRDNVIRAGDSIDDLKLCHDMCGYRVSTTGIVIWKEPWDPSGYEVTERFLELWGWTVEDCWELFESTDRWRVKRGERPLFASLRKLTPYIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MF69</accession>
    <name>B8MF69_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Allantoate permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_012750</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483402.1">
        <property type="nucleotide sequence ID" value="XM_002483357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MF69"/>
    <dbReference type="GeneID" id="8108151"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_012750"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_4_2_1"/>
    <dbReference type="InParanoid" id="B8MF69"/>
    <dbReference type="OMA" id="WATFGYF"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="PhylomeDB" id="B8MF69"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="63"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="485"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="509"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED16168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="532" mass="59701" checksum="D8F3658962E6B211" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFC8</accession>
    <name>B8MFC8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_017370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483896.1">
        <property type="nucleotide sequence ID" value="XM_002483851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFC8"/>
    <dbReference type="STRING" id="441959.B8MFC8"/>
    <dbReference type="GeneID" id="8108994"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_017370"/>
    <dbReference type="HOGENOM" id="CLU_2361157_0_0_1"/>
    <dbReference type="InParanoid" id="B8MFC8"/>
    <dbReference type="OrthoDB" id="4369381at2759"/>
    <dbReference type="PhylomeDB" id="B8MFC8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="96" mass="10916" checksum="ED93F9BA88A3D386" modified="2009-03-03" version="1">MTEPESGFETHPLASQRPRKPPTSASRHNKTPAIPSQLPEYSDDPDDNTDEDIANVPLDFGRSKHSKKRTARIEERWHKYCGVKAAEDGAHLKWHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFF9</accession>
    <name>B8MFF9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_017670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483927.1">
        <property type="nucleotide sequence ID" value="XM_002483882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFF9"/>
    <dbReference type="STRING" id="441959.B8MFF9"/>
    <dbReference type="GeneID" id="8109024"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_017670"/>
    <dbReference type="HOGENOM" id="CLU_052057_0_0_1"/>
    <dbReference type="InParanoid" id="B8MFF9"/>
    <dbReference type="OrthoDB" id="4358517at2759"/>
    <dbReference type="PhylomeDB" id="B8MFF9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="163"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED16693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="391" mass="43308" checksum="5131D1F8FD0A0C2B" modified="2009-03-03" version="1">MPNTRRKACQQCRSSKARCSLALPCSRCVDRGLSCHYPTLRIRDRNKPQLNILPDTTNCPSNNRDSTSDTSYRHSDIITDATSLGDFLQPTELIDWNDVGQNGDLLDLLHTSLVDTNFTSSGFDIRACGAVQASTLQSSTNTSENLSSFVSALNSADTANNIISETTPRVNGPASTSRRNLPSRSPLLRRGQYKQRNSVSTFPSPTTTAAKTLTHKVLRGQIRCYPEMMIRGVVLPHFIHPQCVLRDQSVQDCISDSGAHSCLPESLAICASLMHMFFTKSETSSEFVRSKIYEELCRLHREHTTYDVEALLAAFQASIIYVLVHKEAASSASSQYDEPTNSMLVKCAVRSSTFSGPFFCYSSPMRPMHKGNTFLTQLGVLGYWDAITHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFI8</accession>
    <name>B8MFI8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">sterol 22-desaturase</fullName>
            <ecNumber evidence="6">1.14.19.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_017960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.41" evidence="6"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483956.1">
        <property type="nucleotide sequence ID" value="XM_002483911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFI8"/>
    <dbReference type="FunCoup" id="B8MFI8">
        <property type="interactions" value="1531"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MFI8"/>
    <dbReference type="GeneID" id="8109052"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_017960"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023517_0_0_1"/>
    <dbReference type="InParanoid" id="B8MFI8"/>
    <dbReference type="OMA" id="KCIGLEY"/>
    <dbReference type="OrthoDB" id="1372046at2759"/>
    <dbReference type="PhylomeDB" id="B8MFI8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000249">
        <property type="term" value="F:C-22 sterol desaturase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11082">
        <property type="entry name" value="CYP61_CYP710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000021">
        <property type="entry name" value="Cytochrome P450 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF228">
        <property type="entry name" value="C-22 STEROL DESATURASE ERG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED16722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="532" mass="60269" checksum="5DA967BAD1F18314" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFU8</accession>
    <name>B8MFU8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_009370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483049.1">
        <property type="nucleotide sequence ID" value="XM_002483004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFU8"/>
    <dbReference type="STRING" id="441959.B8MFU8"/>
    <dbReference type="GeneID" id="8100798"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_009370"/>
    <dbReference type="eggNOG" id="ENOG502SK65">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025457_3_0_1"/>
    <dbReference type="InParanoid" id="B8MFU8"/>
    <dbReference type="OMA" id="WINNGIW"/>
    <dbReference type="OrthoDB" id="4225927at2759"/>
    <dbReference type="PhylomeDB" id="B8MFU8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057684">
        <property type="entry name" value="DUF7924"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42470:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42470">
        <property type="entry name" value="VAST DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25545">
        <property type="entry name" value="DUF7924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7924" evidence="3">
        <location>
            <begin position="189"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="458"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED15815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="531" mass="60995" checksum="E3490061713EC932" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFY3</accession>
    <name>B8MFY3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD dependent oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_009710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483084.1">
        <property type="nucleotide sequence ID" value="XM_002483039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFY3"/>
    <dbReference type="GeneID" id="8102767"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_009710"/>
    <dbReference type="eggNOG" id="ENOG502R1TU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028280_0_0_1"/>
    <dbReference type="InParanoid" id="B8MFY3"/>
    <dbReference type="OMA" id="YHYNSEL"/>
    <dbReference type="OrthoDB" id="68575at2759"/>
    <dbReference type="PhylomeDB" id="B8MFY3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877718" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED15850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="53089" checksum="08E25A85CA438297" modified="2009-03-03" version="1">MSQIRVLCMSLFTGLVSSQSTSFDPCAYAPEDVLVRDVIVIGGGASGTYGAIALKDMGRSVAVVEKNPHFGGHVNTYTDPETGLALDFGVQGYGNDSITRAFFSRFDIPLIPLSEGDGQITVDFGTGENVTTLVAGSSMVTYSEQTNMYYPEPALGLHLPQPVPEDLLLPFRDFVTKYSIQNASYTIWRYTSPGKNLLDQLTLYVILGCNAASTPLLGGQGSDVMTRNNSELFGKAEEEVGSNALLSSQVIAAIRSNDSVSLVVQTPTTKKLILASQILFSAPIVLDNLNTFDLDTTEYALFSQVYYSCWYTAVVTDTGLQPGYVYENAASDTLYNIPIEPYTFRIGITRVSTIYTAYYGSMEDLPESEVKARIAENIQIISGNSSIPRFLDFASHVPFKQQVPATAVVNGFYNQLNNLQGYRGMHYTGNALDASGSSSLFNFTLHLLPNINQGIDAHPVDPTRGICNNAEGTDDTTLETPEDTTRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGE6</accession>
    <name>B8MGE6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dipeptidyl-peptidase V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_013660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483500.1">
        <property type="nucleotide sequence ID" value="XM_002483455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGE6"/>
    <dbReference type="STRING" id="441959.B8MGE6"/>
    <dbReference type="MEROPS" id="S09.012"/>
    <dbReference type="GeneID" id="8099165"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_013660"/>
    <dbReference type="eggNOG" id="KOG2100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008615_0_1_1"/>
    <dbReference type="InParanoid" id="B8MGE6"/>
    <dbReference type="OMA" id="LWYRTVI"/>
    <dbReference type="OrthoDB" id="416344at2759"/>
    <dbReference type="PhylomeDB" id="B8MGE6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000028">
        <property type="entry name" value="S9 family peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF13">
        <property type="entry name" value="DIPEPTIDYL-PEPTIDASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="8">
        <location>
            <begin position="492"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED16266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="716" mass="81004" checksum="F8FD7F117644D0DB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIJ2</accession>
    <name>B8MIJ2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_045460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485037.1">
        <property type="nucleotide sequence ID" value="XM_002484992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIJ2"/>
    <dbReference type="GeneID" id="8099510"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_045460"/>
    <dbReference type="eggNOG" id="ENOG502SC56">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1717698_0_0_1"/>
    <dbReference type="InParanoid" id="B8MIJ2"/>
    <dbReference type="OrthoDB" id="4368687at2759"/>
    <dbReference type="PhylomeDB" id="B8MIJ2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="153" mass="17765" checksum="132ECE5EF95949DE" modified="2009-03-03" version="1" fragment="single">FLASVRIEDSPQCECGLGDQDTAHVLIRCPTHINLRMETLWKEARETDYRKLLSEPQWVRQSIEFMMRTGLLTQFHHSNHVDSAWTDQPLDTFGNRTGHQNINITSPRTEILHSFCIYTHFLCWFGVLFARYLLLVVFGSGYGYVSRLSRGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIP2</accession>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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                <person name="Fedorova-Abrams N.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <text evidence="13">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
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        <text evidence="4">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
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        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
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        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
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            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EED15134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002485042.1"/>
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    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="PhylomeDB" id="B8MIP2"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:endosome membrane"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="15"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="17">
        <location>
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            <end position="233"/>
        </location>
    </feature>
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            <end position="381"/>
        </location>
    </feature>
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        <location>
            <begin position="324"/>
            <end position="359"/>
        </location>
    </feature>
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        <location>
            <begin position="1232"/>
            <end position="1277"/>
        </location>
    </feature>
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            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
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            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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    </feature>
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        </location>
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        <location>
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        </location>
    </feature>
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        <source>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED15134.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1278" mass="135319" checksum="93FDDB2A29C0B631" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIV7</accession>
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            <fullName evidence="7">Sugar transporter family protein</fullName>
        </submittedName>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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        <subcellularLocation>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000190">
        <property type="entry name" value="Sugar transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000276">
        <property type="entry name" value="Sugar transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="60"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED15619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="497" mass="54907" checksum="CBEE5BD4A9298999" modified="2009-03-03" version="1">MADIKEARTAQPAEEVSFPEENMSVGRYLATRITSLRPPMHKAPNPFKALALLNRQQWLFFLVAFWGWTWDAFDFFSVSISLTSLAKYFDRPNSEITWGITLVLMLRSVGAIIFGILSDRYGRKWPFVANNALFIVLELGTGFCKTYKQFLACRALFGIAMGGLYGNIAATALEDCPPQARGIISGMLQQGYAFGYLLVTAFARGLVGTTSHGWRPLFWFGACPPVLFIILRLCLPETQAYQSRERVRKSLAGGVAGNFISEGKVAIKNHWKLLIYLVLLMAGFNFMSHGSQDLYPTMLSAQFGFSPNAVTVTQVVANLGAMSGGTLCGWASQIFGRRFSIIVISIVGGALLYPYDFVTDKSVMAVAFFEQFCVQGAWGVIPIHLMELSPGPIRTFAVGTAYQLGNLVSSASSTIESTIGERFPLPPTPKGVKRYDYGKVICIFMGCVYAYVIIVTFFGPEKLGREFDAEHDSDLNEVAARQVFDKDLEKANVQHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJW7</accession>
    <name>B8MJW7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Quinone oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_042590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484737.1">
        <property type="nucleotide sequence ID" value="XM_002484692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJW7"/>
    <dbReference type="STRING" id="441959.B8MJW7"/>
    <dbReference type="GeneID" id="8103421"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_042590"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_0_1"/>
    <dbReference type="InParanoid" id="B8MJW7"/>
    <dbReference type="OMA" id="GHTSVWH"/>
    <dbReference type="OrthoDB" id="3233595at2759"/>
    <dbReference type="PhylomeDB" id="B8MJW7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF5">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="9"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED14784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="352" mass="37714" checksum="AA12495D04DB09FE" modified="2009-03-03" version="1">MYEVIVHAGPKAELVQSPIPSPKADQVVIKVVVSGSNPKDWKTPNLWGWEGMNQGDDIAGIVHEVGSNVVEFKVGDRVAAFHEMRTPGGSYAEYAVAWAHTTFHLPKQTSFEEAATIPLAGLTAALGLFARLRLPTPFARATEPIPTIIYGGSTAVGAFAIKLAQRANIHPLFVVAGSGSSFVDKLIDRSKGDVIIDYRPGPAHLVEQLNTAIQNVGLTKIKYALDAVTTEPSFQVLAKVLDTNGGRYTGVLPYDESVFASGISHSTTTVGNSHASDEKAPGDADLAFAFIRLFGKGLKDGWFTGHPFEVVPNGLAGVEEALRNLKDGKNSALKYVFRIADTPQLREDQPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKH7</accession>
    <name>B8MKH7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sucrase/ferredoxin domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_047780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485285.1">
        <property type="nucleotide sequence ID" value="XM_002485240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKH7"/>
    <dbReference type="FunCoup" id="B8MKH7">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MKH7"/>
    <dbReference type="GeneID" id="8099328"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_047780"/>
    <dbReference type="eggNOG" id="ENOG502RYPV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033921_1_1_1"/>
    <dbReference type="InParanoid" id="B8MKH7"/>
    <dbReference type="OMA" id="VHPESQL"/>
    <dbReference type="OrthoDB" id="10253744at2759"/>
    <dbReference type="PhylomeDB" id="B8MKH7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF8">
        <property type="entry name" value="SUCRASE_FERREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED15332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="31761" checksum="D462A768D0649DA1" modified="2009-03-03" version="1">MFKSLLSSITGGTNKDYIFPAVNTQEDGPDCLKDCSDCTVHLPDKFHIDSERKIYGKVKPFTTHVLVGTGKSDWVSKPEGERGSLVHALCEVSSKERLMVNASNITAHKDDSSTDRDSATTVLLLPSFQLIDNVTISSVPELVARFIDKTSTSSAETSALKPRPCPHDYVVLLCSHKRRDARCGTSAPLIKKELERHLRPAGLYRDATDERPGGVGIFYVSHVGGHKFSANVLVYRKEEGQLIWLARIRPEHCEGIVKYTILQGKVVHPEFQLRGGFDKERGVTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8ML13</accession>
    <name>B8ML13_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_048690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485382.1">
        <property type="nucleotide sequence ID" value="XM_002485337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ML13"/>
    <dbReference type="STRING" id="441959.B8ML13"/>
    <dbReference type="GeneID" id="8107051"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_048690"/>
    <dbReference type="eggNOG" id="KOG4412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_376505_0_0_1"/>
    <dbReference type="InParanoid" id="B8ML13"/>
    <dbReference type="OMA" id="HISAYID"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="571"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="605"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="477"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="689"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="161"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="486"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED15429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="737" mass="82774" checksum="D8F67A0BB73A599B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8ML21</accession>
    <name>B8ML21_TALSN</name>
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        <submittedName>
            <fullName evidence="8">Vesicular-fusion protein sec17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_048770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SNAP family.</text>
    </comment>
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        <property type="protein sequence ID" value="EED15437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002485345.1"/>
    </dbReference>
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        <property type="interactions" value="909"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8ML21"/>
    <dbReference type="GeneID" id="8107059"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_048770"/>
    <dbReference type="eggNOG" id="KOG1586">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046329_1_0_1"/>
    <dbReference type="InParanoid" id="B8ML21"/>
    <dbReference type="OMA" id="WSVKEYL"/>
    <dbReference type="OrthoDB" id="9984275at2759"/>
    <dbReference type="PhylomeDB" id="B8ML21"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:vacuolar membrane"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:soluble NSF attachment protein activity"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:syntaxin binding"/>
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    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:intracellular protein transport"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alpha-soluble NSF attachment protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NSF_attach"/>
    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF8">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00448">
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    </dbReference>
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        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED15437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="291" mass="32652" checksum="496632DA4C39C22F" modified="2009-03-03" version="1">MGDPRALLQKADKALSSASTGFSFFGGRTEKLENAADLYVQAANAFRVQRLNKEAGMAFEKAAAVQKNNLNEPDDAANSLSEAFKVYRKTDPEDAVRVLAGAIQHYISKGNFRRAATHQQNLAECYEVEIGNPKKALEEYEKAAEWYESDNAEALANKYFLKVADLAAIEADYYKAIAHYEKVGKASIDNNLMKWSVKDYFFKAGICHLASGDLVATNRALESYRDIDPSFASTREHTLLVDLLQAVEQGEPDTFADKLFQFDQLSKLDKWKTTLFLRIKENIEEKGEDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8ML29</accession>
    <name>B8ML29_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocation protein SEC62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_048850</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC62 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485398.1">
        <property type="nucleotide sequence ID" value="XM_002485353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ML29"/>
    <dbReference type="FunCoup" id="B8ML29">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8ML29"/>
    <dbReference type="GeneID" id="8100601"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_048850"/>
    <dbReference type="eggNOG" id="KOG2927">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040936_0_0_1"/>
    <dbReference type="InParanoid" id="B8ML29"/>
    <dbReference type="OMA" id="WGWQETK"/>
    <dbReference type="OrthoDB" id="200187at2759"/>
    <dbReference type="PhylomeDB" id="B8ML29"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004728">
        <property type="entry name" value="Sec62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011553">
        <property type="entry name" value="Sec62_asco"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00869">
        <property type="entry name" value="sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443:SF9">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03839">
        <property type="entry name" value="Sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="276"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="71"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="341"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="71"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED15445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="401" mass="43918" checksum="7E21FAA4D8F1E1F0" modified="2009-03-03" version="1">MAAPPGMTPQQMAAFQQHMQQQVATEAAKRGMTPEAFVKMQREQVAAEAAKHGLTPEQYVQGLRMRALQQRAAAQQAAQQGQPGQAQAQQGAPGQPPQGAVPQQQIQKQVNVNPNNPPDPKAIALAKWLRTQDLKTRTCILDGQRKDMFKVKRAIRAIESPAYAKAAAKSKGLLPPVTDRASAENVFKLLPLSLLALRVTKIDPHAGHNHGKTKRVKGLWTVKIEQHQETDPMMHYVFLYEGSQWKQKAMAIGVVLAIFAVVLFPLWPIVLRQGVWYLSVGMMGLLAAFFAMAIFRLVLFCVTVFVVPPGLWLFPNLFEDVGFFDSFKPLWGWQEKKKKKVKLSKKAKSAPSADAQGTSEKAKDTAAPAPAPATAPSRTAPAATDHSSKRSLAASVEDAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8ML91</accession>
    <name>B8ML91_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease H</fullName>
            <ecNumber evidence="4">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_044720</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="4"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484959.1">
        <property type="nucleotide sequence ID" value="XM_002484914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ML91"/>
    <dbReference type="FunCoup" id="B8ML91">
        <property type="interactions" value="244"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8ML91"/>
    <dbReference type="GeneID" id="8104148"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_044720"/>
    <dbReference type="eggNOG" id="KOG3752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030894_0_5_1"/>
    <dbReference type="InParanoid" id="B8ML91"/>
    <dbReference type="OMA" id="ELWYGLY"/>
    <dbReference type="OrthoDB" id="407198at2759"/>
    <dbReference type="PhylomeDB" id="B8ML91"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09280">
        <property type="entry name" value="RNase_HI_eukaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000090">
        <property type="entry name" value="Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.970.10:FF:000001">
        <property type="entry name" value="Ribonuclease H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="11">
        <location>
            <begin position="236"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED15006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="419" mass="45367" checksum="B91AF2E102BA735D" modified="2009-03-03" version="1">MNNHTTITKTTPSPSPGPGLTSGASPAQTTTTAGATSGTKRKRTPAVKYYAVKEGFRPGIYYNWSDCLAQVTGFKGAVFQSFPSLEEATSFLTGQKVASHNGTASTNNENGTRFYGVQRGRVPGVYSNWAEAQEQIKGYTRPRYKKFDTRQEAEEFVKMGQENEVSKSSQIPGGLTNANPTDAVNGDAEIPAAFAPLPPGAEDGFDPNVLLEPSTGKIVYKAPEQKLATKAKPTGPPGMLRIYTDGSSLGNGKKIAQAGVGVYFGPNDTRNVSEPLKGHRQTNQRAELTAIIRALEIAPRHRPVTIVTDSRYAIDCVTNWFRKWVRNNWQTSDGKPVENKDLIQSILVKISERDSLKVTTTFEWVKGHNRDAGNEAADRLAVDGARRGVGGQLSSAPVGLKAAVDDDLPDELADEFDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLE7</accession>
    <name>B8MLE7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acetylornithine transaminase</fullName>
            <ecNumber evidence="5">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_049190</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="5"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485433.1">
        <property type="nucleotide sequence ID" value="XM_002485388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLE7"/>
    <dbReference type="FunCoup" id="B8MLE7">
        <property type="interactions" value="261"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MLE7"/>
    <dbReference type="GeneID" id="8100635"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_049190"/>
    <dbReference type="eggNOG" id="KOG1401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_1_1"/>
    <dbReference type="InParanoid" id="B8MLE7"/>
    <dbReference type="OMA" id="MVPGFKY"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="PhylomeDB" id="B8MLE7"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002325">
        <property type="entry name" value="PRK01278.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED15480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="477" mass="51467" checksum="FC791C6AD78D9599" modified="2009-03-03" version="1">MTIRAAARRLQSVKTVQPLFAARSFSSTSHVYSLPRDEKARILKENSLPTPDPGPDSATAAFLRDRTPYMVPTYVRPTPVFVKGQGVYLWDMENRRFLDLTAGIAVNALGHCDPEITKVISEQSETLIHASNLYHNPWTGALSKLLIDETLASGAMRDASQVFVCNSGTEANEAAIKFARKVGKTLDASGEKVELVSFQGSFHGRTMGALSATPNPKYQQPFAPMIPGFKYGAFNDVEQLETLITEKTCGVIVEPIQGEGGVNVATPEFLIALRERCDQVGAVLIFDEIQCGLSRTGTLWAHANPAFAPKDGSKQPAHPDILTTAKALGNGIPIGATIVTDKVSSAIKTGDHGTTFGGNPLVCRVAHHIVQRLAAPELRNGVEVKSAQFVAGFKQLQEKYPDIISEIRGAGLILGVQLSEKYASKATDVLTAARQRGLLVITAGEGCLRFVPALNITEEQIEAGLKVLRESFEAVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MM78</accession>
    <name>B8MM78_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Guanine deaminase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_098470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485828.1">
        <property type="nucleotide sequence ID" value="XM_002485783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MM78"/>
    <dbReference type="STRING" id="441959.B8MM78"/>
    <dbReference type="GeneID" id="8099675"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_098470"/>
    <dbReference type="eggNOG" id="KOG3968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012358_2_1_1"/>
    <dbReference type="InParanoid" id="B8MM78"/>
    <dbReference type="OMA" id="PWLKTLY"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="PhylomeDB" id="B8MM78"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01298">
        <property type="entry name" value="ATZ_TRZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050287">
        <property type="entry name" value="MTA/SAH_deaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794:SF11">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794">
        <property type="entry name" value="AMINOHYDROLASE SSNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="62"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED13590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="496" mass="53650" checksum="7D9F9E656ED71B19" modified="2009-03-03" version="1">MAADENTILFHSATIITVNNSREVIRNGYIYIINDRIASIGKGYPSNLLPGDTEIIDCKNKIIIPGLINTHAHLVQSLLRGLAEDLPLHNWLCDAIWPLEAVYADDDGYNAAKLTIAEMLKTGTTCFLDPMLTYRAGFERVCDVVGEMGIRGCLGKLVKFIETNRQLSITDPRDKDLIAMSIPALVEAHTAHNGSYDNRLQVWAAAGTPRGAPKYAFQELGDACSEHGISITMHCAEAPRDLEIYRGTYGCSPMEFVEATHLCSAATAAKPRNLVLAHMVNLDLERDIPILASTNTTVAHNPSSNLKLASGIAPVPSMLAHDQYVNVSLGTDGAPCSNHYDMFQEMHLVSILHKGVHNDASLVPAETALEMATINGAKALGLENDIGSLEVGKKADLVILDPYGRGNIGVAPWNPDDDDGEDFNGVTSVTTVVHGCTGRDVYITVVNGRIVVRNGQLADGGCLKEMEIIRKAQSAAKGILRRCNMNRVESQRVGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MM95</accession>
    <name>B8MM95_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_099040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485887.1">
        <property type="nucleotide sequence ID" value="XM_002485842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MM95"/>
    <dbReference type="STRING" id="441959.B8MM95"/>
    <dbReference type="GeneID" id="8103982"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_099040"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_354186_0_0_1"/>
    <dbReference type="InParanoid" id="B8MM95"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="PhylomeDB" id="B8MM95"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="414"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="462"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="576"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED13649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="793" mass="87907" checksum="3975E47834DBB926" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MML7</accession>
    <name>B8MML7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_100170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486009.1">
        <property type="nucleotide sequence ID" value="XM_002485964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MML7"/>
    <dbReference type="STRING" id="441959.B8MML7"/>
    <dbReference type="GeneID" id="8105460"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_100170"/>
    <dbReference type="eggNOG" id="ENOG502SN6G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_0_1_1"/>
    <dbReference type="InParanoid" id="B8MML7"/>
    <dbReference type="OMA" id="CTPVQYY"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="PhylomeDB" id="B8MML7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="32"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="279"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED13771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="386" mass="42500" checksum="1004D63CB71A0A36" modified="2009-03-03" version="1">MSSSHAGIGKWGEVLTIVPIVAAGFATIVYLLRLYSRRLGGTGLATEDFLMGIGLLLSYGATVFVVYTAFNGVGMPSSSLPKWKETNLRFGSWMIQKFWAPSMAFIKISIVVFLQRIMGPIGIFRNICTALIVFIVAWAVTALMGNIFQCWPVTYYYKPYGKGHCMSHQTSFFETMGALSLIVDVCILCLPMPWVLRLHVDLKKKIAVVCIFSMGALVCIFSLLRLVQFRYFLTTNLASSSALESIWTILEMDMAVICGCMPLLTPLFRKCVDRVRTTTSKSTPHSNSHSASRLYARSGSNPSPHWAKFERLGGVDSKTPPHSEASGSRNRQDPLSRQGHNGDELDDDSSIELQGIAVHTVVSLSVESHKSAKDLLEKGSAVEPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8MML9</accession>
    <name>B8MML9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of chromosome condensation, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_100190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486011.1">
        <property type="nucleotide sequence ID" value="XM_002485966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MML9"/>
    <dbReference type="FunCoup" id="B8MML9">
        <property type="interactions" value="1012"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MML9"/>
    <dbReference type="GeneID" id="8105462"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_100190"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005210_4_1_1"/>
    <dbReference type="InParanoid" id="B8MML9"/>
    <dbReference type="OMA" id="TWECNDE"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="PhylomeDB" id="B8MML9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="139"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="209"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="267"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="333"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED13773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="437" mass="47518" checksum="B317712220AF079A" modified="2009-03-03" version="1">MFGINYGGKLGLGDATKKLELPGPVLNQNLSTEAVGVVQLAAGEVHSAALTHSNRILTWAANDEGTLGRDTIVESKKTPIDATSDNGEEDDDDDDDEVELNLKEATPLPVDSSHVPEDGTVFTQLVTTDSATFALTNKGLVYSWGTFRDNNGTARFSPKSTIQRAPALIPDLKDVVKLVAGAQHVSAPISNDTVFSWGIYHSFSIRKTGHLYAWGSNNFGQTGVFQSAGQSDAVISYPTPVPSLEKGSGIVSVTGGKDHSLVVTEQGQCLVWGRIDNNALDIIGQDIPTSDIIFDTYNKPRILKVPTPISSVDGKVVFTAAGTDHSFAIIQDGRAYSWGFNAQRQVGHRNEEEDEVELPTQLKNRHVSGKMLVSVAAGGQFSIFLRLHEPQAKGPSNQHQDRIYPALRNYHRQESYSERDRRDNYRGPFLTQIASMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMN7</accession>
    <name>B8MMN7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_098610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485842.1">
        <property type="nucleotide sequence ID" value="XM_002485797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMN7"/>
    <dbReference type="STRING" id="441959.B8MMN7"/>
    <dbReference type="GeneID" id="8099689"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_098610"/>
    <dbReference type="HOGENOM" id="CLU_832032_0_0_1"/>
    <dbReference type="InParanoid" id="B8MMN7"/>
    <dbReference type="OrthoDB" id="5392779at2759"/>
    <dbReference type="PhylomeDB" id="B8MMN7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED13604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="334" mass="38053" checksum="A61A96F5BC03DEFF" modified="2009-03-03" version="1">MVNQIMRSKRNMKYSLNSSVRSQSCNTGNRTAFLSNELILTRGTSAYDTFSTFNFSAPSFILSLSPNQQSLDASVSLSHYLHSIMPENAVTKMIFTQANYLQTPFHPAVFAQRLSTSHSPVQDALKRFVEIAMKYVTSHDKLMENFDGKDMVPTRLFRSVPVCECWLALQQFNTSFAYERSREGKSAVERLSRVHISLLGRIIERNMLLQSSDKDLRLVCELTRAIDSDLKQSANILSSEPWIIPNLSSSATQKDILKNSATLTVQMHHYYLSLLLHQPILLRGNVHHASAYRGLDPKAWIASVKFLLAHINRHQVSVHDHLEQQRLQDIDIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMY7</accession>
    <name>B8MMY7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_101720</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486174.1">
        <property type="nucleotide sequence ID" value="XM_002486129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMY7"/>
    <dbReference type="STRING" id="441959.B8MMY7"/>
    <dbReference type="GeneID" id="8101860"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_101720"/>
    <dbReference type="eggNOG" id="ENOG502RX11">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024655_0_0_1"/>
    <dbReference type="InParanoid" id="B8MMY7"/>
    <dbReference type="OMA" id="HANETNV"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="PhylomeDB" id="B8MMY7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="244"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED13936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="700" mass="80094" checksum="0E53AD4359B65CEF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B8MN98</accession>
    <name>B8MN98_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_107540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486785.1">
        <property type="nucleotide sequence ID" value="XM_002486740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MN98"/>
    <dbReference type="GeneID" id="8106783"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_107540"/>
    <dbReference type="HOGENOM" id="CLU_3227275_0_0_1"/>
    <dbReference type="InParanoid" id="B8MN98"/>
    <dbReference type="PhylomeDB" id="B8MN98"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED14547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="44" mass="4702" checksum="4E9EC384E1B213A4" modified="2009-03-03" version="1" fragment="single">CLLRPKGNSKHTKAQQAEIQKSYAINLAKARTEGGCSTQLSIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MND6</accession>
    <name>B8MND6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_102560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486263.1">
        <property type="nucleotide sequence ID" value="XM_002486218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MND6"/>
    <dbReference type="GeneID" id="8100832"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_102560"/>
    <dbReference type="eggNOG" id="ENOG502QUGB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_482478_0_0_1"/>
    <dbReference type="InParanoid" id="B8MND6"/>
    <dbReference type="OrthoDB" id="4226546at2759"/>
    <dbReference type="PhylomeDB" id="B8MND6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="200"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="479"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="522"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="522"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED14025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="565" mass="63828" checksum="54DD3DB9A17D4220" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPD3</accession>
    <name>B8MPD3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydroxyindole O-methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_105830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486610.1">
        <property type="nucleotide sequence ID" value="XM_002486565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPD3"/>
    <dbReference type="STRING" id="441959.B8MPD3"/>
    <dbReference type="GeneID" id="8100442"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_105830"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_1_4_1"/>
    <dbReference type="InParanoid" id="B8MPD3"/>
    <dbReference type="OMA" id="CEPEPNM"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="PhylomeDB" id="B8MPD3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF19">
        <property type="entry name" value="DUAL O-METHYLTRANSFERASE_FAD-DEPENDENT MONOOXYGENASE ELCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="207"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED14372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="430" mass="48190" checksum="C05CA7BE147B8E4F" modified="2009-03-03" version="1">MTDLKPSPEEVAQTLMQDVQILMNYYRTNEYPPPSFENGSPAHAVPENAPRHVKIARDAAMNSALKIFDLFAGPSQFLSNLTVSYQSLACLRWLCHFNILKLVPLQGDITFDALAAAANVPKNTLKSIARMAMTARLFYEPTPDRIAHTATSAWLATNQPLHDWALYICKEAVAVALNMVEATEKWPSSTETNQTAFNIALQTDLPFFAHLKTRPEHLRLYSEYQKAVASTEGLDLQHLVHGYDWQALGKAQIVDVGGSIGLASVALATAYPDLSFVVQELPDVVKQGKEYISNLKDESIASRITYATHNFFDDQPIIGAEVYLLRMILHYWSIEESAKILRKLVSVLKPNSSRILVMDTVLPSPGSVTTVTERQLRTRDLAMLQIHNSGERNIEDWEAIYKEADPRLRVKRVHLPFGSQMSVMELVLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPF5</accession>
    <name>B8MPF5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aminoadipate-semialdehyde dehydrogenase, putative</fullName>
            <ecNumber evidence="5">5.1.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_106030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.1.11" evidence="5"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486632.1">
        <property type="nucleotide sequence ID" value="XM_002486587.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MPF5"/>
    <dbReference type="GeneID" id="8100462"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_106030"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_60_3_1"/>
    <dbReference type="InParanoid" id="B8MPF5"/>
    <dbReference type="OMA" id="DCTSWPR"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047462">
        <property type="term" value="F:phenylalanine racemase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="989"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED14394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="2051" mass="227052" checksum="2DB109C08482548C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPI3</accession>
    <name>B8MPI3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_106310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486660.1">
        <property type="nucleotide sequence ID" value="XM_002486615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPI3"/>
    <dbReference type="STRING" id="441959.B8MPI3"/>
    <dbReference type="GeneID" id="8098883"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_106310"/>
    <dbReference type="eggNOG" id="KOG1121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009123_4_0_1"/>
    <dbReference type="InParanoid" id="B8MPI3"/>
    <dbReference type="OMA" id="SYEAWIT"/>
    <dbReference type="OrthoDB" id="2976890at2759"/>
    <dbReference type="PhylomeDB" id="B8MPI3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23272">
        <property type="entry name" value="BED FINGER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23272:SF180">
        <property type="entry name" value="TF-B3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="221"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="305" mass="35548" checksum="35DE93A5835E97CD" modified="2009-03-03" version="1">MDSKLIQYNVTTRWNSSYRMLNDAWNAAPQIQEYLKINHILPPFTDQDWNQLGQIWIVLAEFDRYTLELSTDIPQISQSLAIYYQLFDLLQEVQDREGKFKDFDADIANAAKSAMTKYDKYYTLMDDSCDILYITMLLDPRFKKLVLEHELQDEAKDIITAMQEQLEIQYPIPYKLELPIASEELGLSAALENPHKTIVSEMMSKIKAKSQKSTEKSSDIARYLNSDVVEFNDKKRDWIYTWWRGYINEYPCMAAAARDYLAVPAAEVDVERVFNTGRDLLGLRRWSLSSGTMRKLLILKDSLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQB8</accession>
    <name>B8MQB8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_058090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487431.1">
        <property type="nucleotide sequence ID" value="XM_002487386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQB8"/>
    <dbReference type="STRING" id="441959.B8MQB8"/>
    <dbReference type="GeneID" id="8108945"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_058090"/>
    <dbReference type="eggNOG" id="ENOG502SJ0E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115019_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQB8"/>
    <dbReference type="OMA" id="DHINFAD"/>
    <dbReference type="OrthoDB" id="3454835at2759"/>
    <dbReference type="PhylomeDB" id="B8MQB8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="29"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED13320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="183" mass="21377" checksum="B8D2A0692F2AA229" modified="2009-03-03" version="1">MVDSLIIPPRPAGDPHKQFLCLTICGYKKEGMSEEDYRHHMTQVSAPMTKHLMVKYGVKRWTMIHNQEETRALMKRLFDHQMANLADFDCFSQVIFKDVDDYKRMKDDPWYKQHLVGDHENFADTRRSAMTIGWITEFIRDGEAVDGMKDYQAPTPLGTLIRTTQNVLPVIVVLYGIYRFTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRL8</accession>
    <name>B8MRL8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_056750</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487286.1">
        <property type="nucleotide sequence ID" value="XM_002487241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRL8"/>
    <dbReference type="STRING" id="441959.B8MRL8"/>
    <dbReference type="GeneID" id="8100738"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_056750"/>
    <dbReference type="eggNOG" id="KOG1417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027174_0_1_1"/>
    <dbReference type="InParanoid" id="B8MRL8"/>
    <dbReference type="OMA" id="PGTIPHG"/>
    <dbReference type="OrthoDB" id="1689029at2759"/>
    <dbReference type="PhylomeDB" id="B8MRL8"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000034">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01015">
        <property type="entry name" value="hmgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF4">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HgmA_C"/>
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    </dbReference>
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        <property type="entry name" value="RmlC-like cupins"/>
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    </dbReference>
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    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="14">
        <location>
            <begin position="40"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="13">
        <location>
            <begin position="315"/>
            <end position="467"/>
        </location>
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        <location>
            <position position="326"/>
        </location>
    </feature>
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        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Fe cation</name>
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        </ligand>
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        <location>
            <position position="375"/>
        </location>
        <ligand>
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        </ligand>
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        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
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        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Fe cation</name>
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        </ligand>
    </feature>
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        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>homogentisate</name>
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        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR605708-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED13175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="491" mass="55159" checksum="6C4CDDC5336B2655" modified="2009-03-03" version="1">MPSTSDLQDPKEYQKIFHWAETQKDATIPSFNTRKNDPYKYQEGFGNHFSSEAIPGTIPHGQNSPRNVRFGLYAEQVTATAFVAPRHANKKAWLYRARPAVAHQGFTELPDNKDSESCFLPLNPKIHVSPTQLAWLPTDIPEEETDFVSGLRTFAGSGDPTLREGLATHVYVANKSMTKKAFVNSDGEFLIVPEKGALDIQTEFGPLFVQPGEIVVIQRGLRFRVELPDGPSRGYILEVWGTTFELPELGPLGANGLANSRDFLTPTAQYEVVREPWEIVYKLGGKFFKSTQNHSPFDVVAWHGNYVPYKYDLTKFVNVGSISVDHIDPSIFCVLTAKSRDLTSPLADFLIFSPRWDVASHTYRPPYYHRNAASELMGLIYGEYGGRSDEFMPGSISFECGMVPHGVAYEQFKEATESAPPVMQISPASIAFMFESSRPFTITDYAWNSSKKHEHEPKMWDNLVDNFSSHKKEIDEILVKGLEKLKLNGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8MS71</accession>
    <name>B8MS71_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein disulfide-isomerase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_001970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED12129.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="8098788"/>
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    <dbReference type="InParanoid" id="B8MS71"/>
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    <dbReference type="PhylomeDB" id="B8MS71"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Thioredoxin-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED12129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="260" mass="29242" checksum="6DD4FEFCCFF2B445" modified="2009-03-03" version="1">MKSFALLWKSCHTQLFDYSSIKIGHAIEARKEQRLTHVLKRVTNSFVELDEDRFAIMKTLDLPLIAVTRAKDDDSLIDLIASLANEELAEDFFVGVIPDAESTRKDSLITVFNVLDETTPKYHGPFEKHAILRFASLVSQPLIRQFDMSSLVSFMKSGLPIGMIYSANEDERKLIAQALSNVAMGYRGKVNFATVDAIKNSFALEPMGLKLDQLPAFVIQTDENIYKFSPGERITPEAIDAFVKENLFSGTMQVDRLTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSC0</accession>
    <name>B8MSC0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_000520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED11975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487629.1">
        <property type="nucleotide sequence ID" value="XM_002487584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSC0"/>
    <dbReference type="STRING" id="441959.B8MSC0"/>
    <dbReference type="GeneID" id="8108675"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_000520"/>
    <dbReference type="eggNOG" id="ENOG502S0H3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_26_3_1"/>
    <dbReference type="InParanoid" id="B8MSC0"/>
    <dbReference type="OMA" id="PRANIYD"/>
    <dbReference type="OrthoDB" id="4357294at2759"/>
    <dbReference type="PhylomeDB" id="B8MSC0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="362"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="664" mass="73714" checksum="C82CDEAE2E2435D0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSW5</accession>
    <name>B8MSW5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease/reverse transcriptase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_000980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487680.1">
        <property type="nucleotide sequence ID" value="XM_002487635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSW5"/>
    <dbReference type="STRING" id="441959.B8MSW5"/>
    <dbReference type="ESTHER" id="talsn-b8msw5">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="8108721"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_000980"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_281611_0_0_1"/>
    <dbReference type="InParanoid" id="B8MSW5"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="PhylomeDB" id="B8MSW5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="354"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1112" mass="124413" checksum="F439CFFCD5045E1F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUE1</accession>
    <name>B8MUE1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_108330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488401.1">
        <property type="nucleotide sequence ID" value="XM_002488356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUE1"/>
    <dbReference type="GeneID" id="8106897"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_108330"/>
    <dbReference type="HOGENOM" id="CLU_1696681_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUE1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="155" mass="17894" checksum="DB6697CDB0200679" modified="2009-03-03" version="1">MAEALDSAQEVYEGALKSFDEAFHSLGVVTKETVKRFQPDVDKLAEALENFRELLESRPRKDWTGKQSNLQWSFHGVLGEIKIAQTVIKNGILYKWSVCYLEDAVRVYNEKGHLLHFNYDKASNKLEWVITNDSYPLNLPEPSYELLDTKWIRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUG3</accession>
    <name>B8MUG3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_110150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488591.1">
        <property type="nucleotide sequence ID" value="XM_002488546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUG3"/>
    <dbReference type="STRING" id="441959.B8MUG3"/>
    <dbReference type="GeneID" id="8107247"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_110150"/>
    <dbReference type="HOGENOM" id="CLU_928059_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUG3"/>
    <dbReference type="OrthoDB" id="4233733at2759"/>
    <dbReference type="PhylomeDB" id="B8MUG3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="34100" checksum="86832C60D674B0EB" modified="2009-03-03" version="1">MAVPEGGPQTPENSARNEAILRAPGRRQNLQAETLRTLVVEFSPLDDGKRILYQMVAKLINGLNTAIIQQTNTIDTARPETADNNGNNKDNFTRFLPTDTANKHIRMALSTTKPIKDVQLNTPEAAESIISNGLLVGQRYIGSVEPYKVELKRCYCCQKFGHLAWLCKEQLNIWKSRAGMEALINNHQSQNLDLLLIQEPSITTYRTYVNHSAWRLYRPTYLNTNESIRFRSLLYVNKRISTSSHRQIHCNHPDLVAIKVWTAEIQFLIFLVYIPSLDIYQATSTTSAKSALKEIKNTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUQ7</accession>
    <name>B8MUQ7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_109050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488480.1">
        <property type="nucleotide sequence ID" value="XM_002488435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUQ7"/>
    <dbReference type="STRING" id="441959.B8MUQ7"/>
    <dbReference type="GeneID" id="8103161"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109050"/>
    <dbReference type="eggNOG" id="ENOG502SK65">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025457_0_1_1"/>
    <dbReference type="InParanoid" id="B8MUQ7"/>
    <dbReference type="OMA" id="QYERIAW"/>
    <dbReference type="OrthoDB" id="4225927at2759"/>
    <dbReference type="PhylomeDB" id="B8MUQ7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057684">
        <property type="entry name" value="DUF7924"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42470:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42470">
        <property type="entry name" value="VAST DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25545">
        <property type="entry name" value="DUF7924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7924" evidence="2">
        <location>
            <begin position="140"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED11724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="371" mass="42741" checksum="6022A9DE004372C0" modified="2009-03-03" version="1">MKRAIASDSHDDVGQRPAKLRRRDSSSTVPIPSSKRQEQITLQPPSPLSNNVSSRKINEQECGHSAIVPPSKPINKRQEILEWIPYPSEEFDEVDIMKTKGCFMRQSPAGPTSEEVALCQRLLHQPVETPRGTLFDSEFIESFHDALRNRSEARLLIDLHPLLIPSAENLFIQGKEELKDVIDGYNDPWLRLGPIYGPKPQPDHARGLRWSTFSDIQRRKLGIKPDEKSLYAVREDMYFPYLTAEIKCGNQALEFADRQNMHSMCIALRAVVSLAQAAGCPEEVHRKLLGFSISHELETVRIYGHYPEIGEDGIKYYRWLVKQFNIWIEEDKWACYHFVENLDREFLPIHTGRLMHLLRDIGIDVEKNKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUV4</accession>
    <name>B8MUV4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_110620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488639.1">
        <property type="nucleotide sequence ID" value="XM_002488594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUV4"/>
    <dbReference type="GeneID" id="8107294"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_110620"/>
    <dbReference type="HOGENOM" id="CLU_565222_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUV4"/>
    <dbReference type="OrthoDB" id="10485476at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="483" mass="54328" checksum="8BD2B51BDBE956FF" modified="2009-03-03" version="1">MASESFRLDSRYPLNTGLYFPPKDGYYWNTNKLGGLDPRPGNPGYFAVLKRVVSDANIQNRAELAKYVFEGEELFKKCGFTSSMMKDARIKAEGHLKSRQQCIEQKWKEAIGPLSDNAGKFDEWIKVYAEKTAYGQAAAATWVTKIDASLSDLEESLQNELLIDRETAREYFSILAKAVESRISDVLASYTNAFEQLYLTVGIKEEVEAFIKFEKELSIMPMVAGAPSSAPKGLGRNAPFGMTPCADVVVSFIGDGELYVGIIEPSDDSGVSKMLGGKRDPKYHVADDGSLYVTRDLAKDTALKEFMEETGADKVETLTLNETQLGLLGKFAGDWETVLNSLNCRITHTKETNEVKVTWSQEAMIATGEGIKKLLKPIRMDITVPDNRTTLNAGYSTTVYQANINTNNRDQRRLLTLVLTRQGSEEGRYLFRCATEVEMQSTHKHIFKECFLEKKWSSYLRLILLLTSMITNVCAYFWSFFYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B8MV93</accession>
    <name>B8MV93_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_008450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962662">
        <property type="protein sequence ID" value="EED11549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488730.1">
        <property type="nucleotide sequence ID" value="XM_002488685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MV93"/>
    <dbReference type="GeneID" id="8108579"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_008450"/>
    <dbReference type="HOGENOM" id="CLU_664258_0_0_1"/>
    <dbReference type="InParanoid" id="B8MV93"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="429" mass="49371" checksum="EE9B2522A5FA126A" modified="2009-03-03" version="1">MLWHKMSQNGNKKKINPRMSGTQEALGLENDKAKFQKTGQLIKELSQKSTQQNVLQRGNEKQFQTWREDNIFPAFKKRYPELFFRVRVEFKTPLQNSLPQKKTILELNKRQKGLRKTRIDRENNKQQDMLKSEQKHQRKQKAQKVVEPSAMVERQSELGFAINPSTEERQRSRDNQSKDTVLDQDTSSTGDNGFGSVEIIGTYIYGHSERQEEVSKEQPEEEEEAMEITVDQGETTSETDVNTIRATVIQTTRIPFLGPIHEPSTSYNAAMVLIDAILDPKNSCEPVELRISYKAWQKKLGKHWGVDFEGLSSSCTMHFFWNENWINVPWSDTSWQAMVNLCLQGNRTRLIQVQICGDGPDFVTSRTKSLQSTSHETAPGERSRKLDTIDAGIRAEMKSVITSFKRELGMLDFKNDYDLTLKMPPSLKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8LT03</accession>
    <name>B8LT03_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ferritin</fullName>
            <ecNumber evidence="6">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_064650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ferritin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="6"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340386.1">
        <property type="nucleotide sequence ID" value="XM_002340345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LT03"/>
    <dbReference type="SMR" id="B8LT03"/>
    <dbReference type="STRING" id="441959.B8LT03"/>
    <dbReference type="GeneID" id="8102376"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_064650"/>
    <dbReference type="eggNOG" id="KOG2332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1272676_0_0_1"/>
    <dbReference type="InParanoid" id="B8LT03"/>
    <dbReference type="OMA" id="WNSAKDA"/>
    <dbReference type="OrthoDB" id="186462at2759"/>
    <dbReference type="PhylomeDB" id="B8LT03"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431:SF75">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0409">Iron storage</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="7">
        <location>
            <begin position="24"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601519-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED22999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="244" mass="27402" checksum="3A5CBD93D6BA9346" modified="2009-03-03" version="1">MGESAGSIISDVSHQNIDTWLRPSTFTNELEESVRGHIHQELTSWLFYRKLAADCSRSNLALHGFAMLWERSAWECLLDMNWLEKYLVTRGGRSKPTNIEAPKIDFPDSPVEPVGPCREAFTVQKKLFEDLQRLVTLAEKQQDTALVTAIESRYLRKHAKHLKNLGDLVQQVARVSKQHGLGLYLLDSELRRHNGVIPWMSLNDPDSHFESVSVLTKKINEGLALDAHAAHHQGGAHGAKGSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTN2</accession>
    <name>B8LTN2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_070370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341011.1">
        <property type="nucleotide sequence ID" value="XM_002340970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTN2"/>
    <dbReference type="STRING" id="441959.B8LTN2"/>
    <dbReference type="GeneID" id="8107310"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_070370"/>
    <dbReference type="eggNOG" id="ENOG502SC56">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2122719_0_0_1"/>
    <dbReference type="InParanoid" id="B8LTN2"/>
    <dbReference type="OrthoDB" id="4368687at2759"/>
    <dbReference type="PhylomeDB" id="B8LTN2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED23624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="114" mass="12543" checksum="69A31C5144809261" modified="2009-03-03" version="1">MDEYIDVTLRWIPGHEGIPRNEAADRAAKRAALIGARRQIVPGDIGNWTILAAAAKRRIRQSTKDAWEKQWDKQKAGKPTKKLTSPRPAGHPDDPDRDPDHGGSGVISPNPDPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B8LU41</accession>
    <name>B8LU41_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_060110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002339900.1">
        <property type="nucleotide sequence ID" value="XM_002339859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LU41"/>
    <dbReference type="GeneID" id="8108548"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_060110"/>
    <dbReference type="HOGENOM" id="CLU_2544148_0_0_1"/>
    <dbReference type="InParanoid" id="B8LU41"/>
    <dbReference type="OrthoDB" id="10406149at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED22513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="83" mass="9232" checksum="3E6F3CEC03F93178" modified="2009-03-03" version="1">MLELAISLANHLVTLKQLDAEKLRDTIDQAQMMVPLDVHIYRLHRDICISLSDASAHKRDEDCCQVSLSAIGDSMAEVLDPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUH4</accession>
    <name>B8LUH4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_071440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341134.1">
        <property type="nucleotide sequence ID" value="XM_002341093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUH4"/>
    <dbReference type="STRING" id="441959.B8LUH4"/>
    <dbReference type="GeneID" id="8102532"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_071440"/>
    <dbReference type="HOGENOM" id="CLU_1714525_0_0_1"/>
    <dbReference type="InParanoid" id="B8LUH4"/>
    <dbReference type="OrthoDB" id="10466351at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED23747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="153" mass="17573" checksum="EBE0736CCCE3F816" modified="2009-03-03" version="1">MIEDLLQLGLVYHTIKCAVDDISPTFDFRGNLPLPYRSVSGEERDEPLSASEIDKWRSQYAPLDEVKSTYRLMYLLGIGHSEEEATVLSEINESDLDFALHREKYPGDSLSFKKIKLCGELPAQRFSSWDEGKEFLRHEHPKQISYMESISGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUQ7</accession>
    <name>B8LUQ7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-activated protein kinase glycogen-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_073040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRP1/MDG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341301.1">
        <property type="nucleotide sequence ID" value="XM_002341260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUQ7"/>
    <dbReference type="FunCoup" id="B8LUQ7">
        <property type="interactions" value="73"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LUQ7"/>
    <dbReference type="GeneID" id="8110219"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_073040"/>
    <dbReference type="eggNOG" id="KOG1616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011453_3_0_1"/>
    <dbReference type="InParanoid" id="B8LUQ7"/>
    <dbReference type="OMA" id="TFDNWTK"/>
    <dbReference type="OrthoDB" id="5873279at2759"/>
    <dbReference type="PhylomeDB" id="B8LUQ7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF81">
        <property type="entry name" value="CRUCIFORM DNA-RECOGNIZING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-activated protein kinase glycogen-binding" evidence="3">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="374"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED23914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="465" mass="48534" checksum="1AC40844215BC176" modified="2009-03-03" version="1">MGSYVFRWPREATEVYVTGTFDDWGKTVRLEKNGDVFEKEVHLPTIDGKIQYKFVVDGSWVTDSDARQESDGHNNINNVLLPEDLKSAAKPNTEVDSLTGGNTAAAVMAGVVPEATTAQLAGEVPKENNASSVPGGFPETPATEAANELSVNPIPATNGIGNPVKLTPGEPVPDPSTLSGNTVESTVRTDKEGYEADASNPVFLNKEEQAKADPLSVPPVSTGGLIPESSLPMNPPETAETPGVTIQSVHPTSTTAALAAEVPLESQKNAEVASDVPKVVKESLTKAHEAPEAAANAEAVEEKAEVEKELQNKVGLADAPAVPASDVPEVVKESLEKAHQDPEAAASEAAVEEKKEVEQELQQKVHPTEQAGEPAPITSAATTATAPTVESTDVSPQTSPPATAAATSAPSTTTQTQPTVTTGVASGTTTAESKPVAGAPQDNSKEKKKKHRASGFFQKLKEKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUW5</accession>
    <name>B8LUW5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sodium bile acid symporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_060780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002339973.1">
        <property type="nucleotide sequence ID" value="XM_002339932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUW5"/>
    <dbReference type="FunCoup" id="B8LUW5">
        <property type="interactions" value="420"/>
    </dbReference>
    <dbReference type="GeneID" id="8108542"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_060780"/>
    <dbReference type="eggNOG" id="KOG4821">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039013_3_0_1"/>
    <dbReference type="InParanoid" id="B8LUW5"/>
    <dbReference type="OMA" id="RYVFKQL"/>
    <dbReference type="OrthoDB" id="188035at2759"/>
    <dbReference type="PhylomeDB" id="B8LUW5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016833">
        <property type="entry name" value="Put_Na-Bile_cotransptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640:SF5">
        <property type="entry name" value="SODIUM_BILE ACID COTRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 10 MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13593">
        <property type="entry name" value="SBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED22586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="404" mass="44577" checksum="46FB7903D47787B4" modified="2009-03-03" version="1">MAGSPNDCSATQVWTGEPDTVTSSELPREQEHVSSAEKPHRSWLMRVLLGIGELAIDQWFLIVMAILIAFASQVQVPHAKQKLKQTVVDYLAVAVIFFINGCTLPTKLLVENLSKWKMHIFVQIQCYLLTSSISFGVVSATATSHYFMDPSLLIGIIILGCLPTAIAFNTIMTRKANGNTALTIAQSTIGNILGPFVTTALIKLYTSTHVWYTDMLPKTGGNFGETYRYVFKQLGLSVFVPLVVSQIVVSIFPNFTTNVLVKWKASKIGSFALLVIIWDTYDGAFAFKAFDDIPSDNMVFIVFILVALFFVWITIAFVISRVWLSREDAIAVSYLVPTKTPAMGVPLTTIMFVGLSAAAQSRMRLPMVIFQAIQTSASSLLTIPLRKWQAQGKVERDSDGPECP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVQ6</accession>
    <name>B8LVQ6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">3-dehydrosphinganine reductase</fullName>
            <ecNumber evidence="14">1.1.1.102</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSTA_075580</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the reduction of 3'-oxosphinganine (3-ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>sphinganine + NADP(+) = 3-oxosphinganine + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.102"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:22642"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.102" evidence="14"/>
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        <property type="protein sequence ID" value="EED24186.1"/>
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    <sequence length="2250" mass="247663" checksum="929F0E3C587322A6" modified="2009-03-03" version="1"> </sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046559">
        <property type="term" value="F:alpha-glucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005154">
        <property type="entry name" value="Glyco_hydro_67_aGlcAse_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011100">
        <property type="entry name" value="Glyco_hydro_67_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39207">
        <property type="entry name" value="ALPHA-GLUCURONIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39207:SF1">
        <property type="entry name" value="ALPHA-GLUCURONIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07488">
        <property type="entry name" value="Glyco_hydro_67M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03648">
        <property type="entry name" value="Glyco_hydro_67N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002874510" description="Alpha-glucuronidase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha glucuronidase N-terminal" evidence="3">
        <location>
            <begin position="24"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 67 catalytic" evidence="4">
        <location>
            <begin position="138"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED24208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="43672" checksum="AE6866787891BDA7" modified="2009-03-03" version="1">MHAFLYIIPTCLISPAIAENGLDGWLRYALLPASLTSHFLTGFPSNIITLNSSINSLVYTAARELQKGLRGIRHKDVDIICSNKSQSQFASIVIGTVDIFTKTFGIGNSWDDLIQDGFSLNISENSVRIIGRNERGTFNPHAPIRCVNQWDNLDGSIERGYEGSSIFFENGVIVRDLTRAAEYARLLASIGVNAVVVNNVNANSSLLTPENIQGLSRIADVFRPLCFAAGGWGLSIYDPLDPGVIKFWWNITNQLYEAVPDMVGYLVKADSEGQAGPLVYNRTLAQGANLFANSLKPHGGVLMFRSFVYNKLNESDWKADRANAAVEFFKDLNGEFDENVIVQIKYGPIDFQVCEPVSPLFANLPHTNTALELQITSGIPRSAMSFGLYASIMEDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVU1</accession>
    <name>B8LVU1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine Rich Repeat domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_075930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341608.1">
        <property type="nucleotide sequence ID" value="XM_002341567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVU1"/>
    <dbReference type="STRING" id="441959.B8LVU1"/>
    <dbReference type="GeneID" id="8105114"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_075930"/>
    <dbReference type="eggNOG" id="ENOG502R9EV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025206_1_0_1"/>
    <dbReference type="InParanoid" id="B8LVU1"/>
    <dbReference type="OMA" id="TKQMNAE"/>
    <dbReference type="OrthoDB" id="9994419at2759"/>
    <dbReference type="PhylomeDB" id="B8LVU1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="163"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED24221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="635" mass="70553" checksum="345E672C6CD01B8B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8LX63</accession>
    <name>B8LX63_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_062010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340100.1">
        <property type="nucleotide sequence ID" value="XM_002340059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LX63"/>
    <dbReference type="GeneID" id="8105620"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_062010"/>
    <dbReference type="eggNOG" id="ENOG502SKW0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_639649_0_0_1"/>
    <dbReference type="InParanoid" id="B8LX63"/>
    <dbReference type="OrthoDB" id="4227368at2759"/>
    <dbReference type="PhylomeDB" id="B8LX63"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED22713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="429" mass="49485" checksum="1829D93B830C6EE5" modified="2009-03-03" version="1">MSMRERKRQNIHSAFRSASRRTMLAAGTQLRLLENFIKTVKQPPYMKLERQTLGVIRYEKESGKVILVNICAQLWPEYLQLRKTSKHKKTNLAGCHGEGLKIATMVMSWNGYAVKIYSNSYTWSFCFQGLTDSQMHCLITPATVLPLAQVNVAQDTNCFVPCICRDVSIIIERGHDGSRVSLEEFRRWLTVSLDIRGFSYPASIVETDHGNLILDPDYQGKVYLKGLYLPSPSSDARSYKLGYNFADGKVNCDRHRELIWKFLLKESNGRQFFYCDRFGPHSFDTIKEGLKKEPISLPDILWNMLRANSLLRTANEEQFYSFKKAKICKVPETLFAKNVERGLKASMALWKVIEKIEFVESRNVNVEMVFDPGENSLKVHNQWLDYGAMHTKYRCRSIVPKDSFVCDHIVEELVRGVMGVIFKKFIARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXB5</accession>
    <name>B8LXB5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_066430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340583.1">
        <property type="nucleotide sequence ID" value="XM_002340542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXB5"/>
    <dbReference type="STRING" id="441959.B8LXB5"/>
    <dbReference type="GeneID" id="8100197"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_066430"/>
    <dbReference type="HOGENOM" id="CLU_1732700_0_0_1"/>
    <dbReference type="InParanoid" id="B8LXB5"/>
    <dbReference type="OrthoDB" id="2322999at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED23196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="151" mass="17573" checksum="EA41AF39E8C110EF" modified="2009-03-03" version="1">MYDPRAYNSLPSLRQAAERLDGHATKHLFGEIRQVFLDNNAHEKYGISVLHKHFPIGEEDRLVDCRHTPTAWKVLPFLDSARSQFAVCIGGITLFRLTEEEMFVARVEKFGECRISSLLYFEVQVPFRFLSSSFRFFSSSFCFLKTLAYFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXI0</accession>
    <name>B8LXI0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P-type Na(+) transporter</fullName>
            <ecNumber evidence="19">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">TSTA_078400</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="19"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341868.1">
        <property type="nucleotide sequence ID" value="XM_002341827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXI0"/>
    <dbReference type="STRING" id="441959.B8LXI0"/>
    <dbReference type="GeneID" id="8109422"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_078400"/>
    <dbReference type="eggNOG" id="KOG0202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_3_0_1"/>
    <dbReference type="InParanoid" id="B8LXI0"/>
    <dbReference type="OMA" id="ISWEWAL"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="PhylomeDB" id="B8LXI0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000015">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000039">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000047">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="25" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="335"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="803"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="876"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="928"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="984"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1014"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="24">
        <location>
            <begin position="16"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="419"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EED24481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1079" mass="117782" checksum="8EB6274207EA4DA2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXI3</accession>
    <name>B8LXI3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">pH-response transcription factor pacC/RIM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_078430</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the pacC/RIM101 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341871.1">
        <property type="nucleotide sequence ID" value="XM_002341830.1"/>
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    <dbReference type="AlphaFoldDB" id="B8LXI3"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_027084_1_0_1"/>
    <dbReference type="InParanoid" id="B8LXI3"/>
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    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="PhylomeDB" id="B8LXI3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000340">
        <property type="entry name" value="zinc finger protein 473 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF20">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="149"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="207"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="30"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="225"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="308"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="414"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED24484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="444" mass="48477" checksum="9EA3071769711B9E" modified="2009-03-03" version="1">MEIPTILNRKASAAVAADPRFQAQLAQAVHMHTQEMSEQATSQPGDHTVMGYPPNAQPLHQTQQMAPQLWPTHPNGAPVMPPNGYVHTGFPAVPPQQSHTPPVQQQQQQQQSRPEPAPRVFHCSTCQKGFARRSDLARHERIHSGIRPHACDWPGCGKQFIQRSALTVHARVHTGEKPHMCERCGKPFSDSSSLARHRRIHSGKRPYKCPYANCQKTFTRRTTLTRHQNHHTGTIEEAAAQTEASLRQNRERSARASEGIYSETGSGHSTPSPGQQASMGMGSELPPLNIIRSTGEYYIPNGGIPAHVRGDFQQGSPRASPAATSPSLSSYSSHPRPSMTSHPSGYGPPQPLEPPANNDHRPGSVTGSPHMTSMGWASPSHGSMPSPGSPHDFGYPESNVAAYASAMPPHMYFPNSTIRRPGSTEPENYEMKPRIGPDGWSTPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8LY07</accession>
    <name>B8LY07_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Twinfilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_063050</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with G-actin; ADP-actin form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340209.1">
        <property type="nucleotide sequence ID" value="XM_002340168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LY07"/>
    <dbReference type="FunCoup" id="B8LY07">
        <property type="interactions" value="388"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LY07"/>
    <dbReference type="GeneID" id="8099964"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_063050"/>
    <dbReference type="eggNOG" id="KOG1747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031995_0_0_1"/>
    <dbReference type="InParanoid" id="B8LY07"/>
    <dbReference type="OMA" id="YLFKHTH"/>
    <dbReference type="OrthoDB" id="10006997at2759"/>
    <dbReference type="PhylomeDB" id="B8LY07"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11284">
        <property type="entry name" value="ADF_Twf-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11285">
        <property type="entry name" value="ADF_Twf-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000042">
        <property type="entry name" value="Actin depolymerizing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000007">
        <property type="entry name" value="Twinfilin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028458">
        <property type="entry name" value="Twinfilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759:SF1">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ADF-H" evidence="12">
        <location>
            <begin position="4"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="ADF-H" evidence="12">
        <location>
            <begin position="196"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED22822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="344" mass="37517" checksum="92AFD82AF1D1BA0C" modified="2009-03-03" version="1">MQSGISVSQDLHDAFQAFTSDDSAFALPITIDSESLQPRPPIPFAESSFYSSLPQLQSILEPRTPLFLVLRHHSPAVSGLLALTYIPSNAGVRAKTLFASTRATLTRELGSEKFATTIFATEEEEVYGEDAWKERDLEGNGTSTASFKREDLMDEKERELEAVRRAEEEARHGTAGRDVGTGGSLGRVSGIATGGGMRVNMPVDEDAKTALRNIQEEGLVQLSIDVKSESIKLNATESNVSPSAVASHISDSSPRYTFYRYPGSTIVIFIYTCPSGSSIKEKMLYASTRRVAIQIGEAEGIQIDNKIEGSSPDEITAARLQEEVTPRQDEGPKRGFARPKRPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYD6</accession>
    <name>B8LYD6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_063450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340252.1">
        <property type="nucleotide sequence ID" value="XM_002340211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYD6"/>
    <dbReference type="STRING" id="441959.B8LYD6"/>
    <dbReference type="GeneID" id="8102423"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_063450"/>
    <dbReference type="eggNOG" id="ENOG502S4C0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1714522_0_0_1"/>
    <dbReference type="InParanoid" id="B8LYD6"/>
    <dbReference type="OMA" id="PAKMNTS"/>
    <dbReference type="OrthoDB" id="4590707at2759"/>
    <dbReference type="PhylomeDB" id="B8LYD6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED22865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="175" mass="18971" checksum="063665DFAF0BA3FA" modified="2009-03-03" version="1">MRIKAAMMSSRLPRILRGTALSPQARFVAANIRNRQQVIARRSYAEAADNNVHERRKGNFPWLVLSVAITVPAAWYLWSSGPKETSQGAGPKRPAVKGPEEGRQVSGEKQSERDPAHAIKPEGNIGENSGAQTSKQQGVSNDDTMNPYLNAPGKGEKPEGVTDSSKLKGTVSPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZ35</accession>
    <name>B8LZ35_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_083120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478042.1">
        <property type="nucleotide sequence ID" value="XM_002477997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZ35"/>
    <dbReference type="GeneID" id="8105190"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_083120"/>
    <dbReference type="eggNOG" id="ENOG502RAVW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1653309_0_0_1"/>
    <dbReference type="InParanoid" id="B8LZ35"/>
    <dbReference type="OMA" id="SRDPDYN"/>
    <dbReference type="OrthoDB" id="3912021at2759"/>
    <dbReference type="PhylomeDB" id="B8LZ35"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED21079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="160" mass="17649" checksum="6C547D5B6A9EE201" modified="2009-03-03" version="1">MNMFTSLYRRACDESDPNSDACAKPTSNVLLDAVPAAVVGVMLIIAGTVFFYIARKRRRQFDAEEAKERESFEIDIYEPTAKNHRPNPAGHADPFNDPHGLSRDPDYNEFSLAAPQSRRDRSPSKSSIATESTYMPSAPPPAYHEGNTGATVSRPSDTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZA0</accession>
    <name>B8LZA0_TALSN</name>
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        <submittedName>
            <fullName evidence="5">Transposon, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_088890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478616.1">
        <property type="nucleotide sequence ID" value="XM_002478571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZA0"/>
    <dbReference type="GeneID" id="8104856"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_088890"/>
    <dbReference type="eggNOG" id="ENOG502S2ZX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_4_0_1"/>
    <dbReference type="InParanoid" id="B8LZA0"/>
    <dbReference type="OMA" id="DTSATIC"/>
    <dbReference type="OrthoDB" id="6115549at2759"/>
    <dbReference type="PhylomeDB" id="B8LZA0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="60"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED21653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="548" mass="62550" checksum="636B4B8AB930BB78" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8M084</accession>
    <name>B8M084_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_084120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478144.1">
        <property type="nucleotide sequence ID" value="XM_002478099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M084"/>
    <dbReference type="STRING" id="441959.B8M084"/>
    <dbReference type="GeneID" id="8101505"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_084120"/>
    <dbReference type="eggNOG" id="ENOG502RNTC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1005350_0_0_1"/>
    <dbReference type="InParanoid" id="B8M084"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="PhylomeDB" id="B8M084"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="277" mass="30053" checksum="A40D080154DE86BE" modified="2009-03-03" version="1">MTLILPPAGSQFSMTTQIMKSRRTAPETILPIDPAILDDETPCALAYDWQDSGVSGSVFPDELSQESDSTRDRFARAAPSYDPPDQQTHLSDAHITEVETGTGAVQPICGDSSQELSFNKRQTAPEYDSGQLSNRVCTRTTPSENVNPPVLPALYSHFLTAPVDDRMEFLSWLFEGALLQCMSGFPTTLEPSLNKARTKGTGRRQARKLVPTASKSAPSLVKSRKGMPWESISFGVEGNRLFGSAEESRKVAMAGCGEAVYGTVSWEDGRVDSGVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0N3</accession>
    <name>B8M0N3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_086490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478379.1">
        <property type="nucleotide sequence ID" value="XM_002478334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0N3"/>
    <dbReference type="GeneID" id="8109512"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_086490"/>
    <dbReference type="HOGENOM" id="CLU_1373021_0_0_1"/>
    <dbReference type="InParanoid" id="B8M0N3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED21416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="199" mass="22768" checksum="B058F52B2553FB67" modified="2009-03-03" version="1">MHDLLEVQARLLERHCNCLLMEQVEQCFHMINGITEHELVPLHQTLEDVSTDNDDDRGQDEEMTIEESCLNLDTIHSIQTEPRHYLDGDDVALPEQRLRQKVGHAGSFVQMYAQGHWYPGRVKRCVLLVEAFTPAIRFQIGTENVDVEAGIYVKIELSPTRHPEAYARKALKTDPSSRLAIKIKGKLKNGEIFEEDSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0Y1</accession>
    <name>B8M0Y1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">COP9 subunit 3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_090000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478724.1">
        <property type="nucleotide sequence ID" value="XM_002478679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0Y1"/>
    <dbReference type="STRING" id="441959.B8M0Y1"/>
    <dbReference type="GeneID" id="8108088"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_090000"/>
    <dbReference type="eggNOG" id="KOG2582">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028825_1_1_1"/>
    <dbReference type="InParanoid" id="B8M0Y1"/>
    <dbReference type="OMA" id="NHYHDLV"/>
    <dbReference type="OrthoDB" id="29061at2759"/>
    <dbReference type="PhylomeDB" id="B8M0Y1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055089">
        <property type="entry name" value="COP9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF1">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22788">
        <property type="entry name" value="COP9_hel_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COP9 signalosome complex subunit 3 N-terminal helical repeats" evidence="3">
        <location>
            <begin position="36"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="463"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED21761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="496" mass="56061" checksum="EA1B2DF9C3684AA2" modified="2009-03-03" version="1">MDHVLHQLRSFPSPADTSHEAYETHALEYYVSTRKHLQHILDSPEKAQNVLELLDPSTHSLAYLLVLNFYINQTKLRARNMETGDLLPGNILWSRALSLLKSFDPNQIRRAAREWRNVLEFISGAAEAGNKALLAIRPVRDAIIRMDPTCATFTVAHLYLTRLCLLAKAYKVARPVIDRTIFAIPSSADRLFIQHSQGESGFHGSTRPYLFEPPMKLTYAEHLQYFIYGGMIYMALKEWSKARHFLSIVITCPVVNAVSLIMVEAYKKWVLVNLIENGTTASVPKITSPLAMKTYKALARPYDALATAFISGKWERLKDEAEAGQTIWSDDNNNGLVQQVLLSFRKKAVRGLGATFASVTTTDVSQRALSNSMDVRETERYIVALAVKEGFPASLIHPSRDPNTSMLRFLTDHSESSIGLEVSLEEQLRSQHQKLELLIQNIQTSDRKLELSKEYISHLRKAQKRNDAASKGTVGFSGRKRDQNVDLDEDMMDELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1F2</accession>
    <name>B8M1F2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MAK1-like monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_090880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478811.1">
        <property type="nucleotide sequence ID" value="XM_002478766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1F2"/>
    <dbReference type="STRING" id="441959.B8M1F2"/>
    <dbReference type="GeneID" id="8101578"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_090880"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_1_1"/>
    <dbReference type="InParanoid" id="B8M1F2"/>
    <dbReference type="OMA" id="HEIIFNY"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="PhylomeDB" id="B8M1F2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000331">
        <property type="entry name" value="FAD/NAD(P)-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF187">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="131"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED21848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="426" mass="48315" checksum="06F0B65E2504F8A0" modified="2009-03-03" version="1">MAISNGYSTRERTGVKVVIVGAGFGGLTAAIECHRQGHEVEIYESFPQLKVLGDIISFGPNAGRIYKRWSNGEIADQMRALSIDLSKYGFRIHKYDTGEIITTQKSSPRDPDAPVFNGHRGELHSIVFKYARDELGIPIHLGQRVRQYWEEEEQASIVLDDGRRVSADVVIGADGVRSKARELVLGYVDKPKSSGYAVYRAWFPNTDMIKDPRTKQFCENGDTFNGWIGPDVHFLFSTIKNGSDCCWVLTHRDEADIDESWSFPGKLEDVYNFLEGWDPMCKAIVEKTPSVVDWKLVYRDPLPRWVSDKGRITLLGDSAHPFLPTSTQGATQAMEDGVTIAVCLKRAGSRDRIPAAVRAYQDIRYDRVRKIQKTGESTRDMWHKADWDKVKKDSSSIHLPREDWIFAHDAEKHAEEVFDDVIKKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1J0</accession>
    <name>B8M1J0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nuclear pore complex protein An-Nup82</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_091270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478849.1">
        <property type="nucleotide sequence ID" value="XM_002478804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1J0"/>
    <dbReference type="STRING" id="441959.B8M1J0"/>
    <dbReference type="GeneID" id="8101616"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_091270"/>
    <dbReference type="eggNOG" id="ENOG502QUNM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009483_0_0_1"/>
    <dbReference type="InParanoid" id="B8M1J0"/>
    <dbReference type="OMA" id="WHPLGVH"/>
    <dbReference type="OrthoDB" id="341482at2759"/>
    <dbReference type="PhylomeDB" id="B8M1J0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037700">
        <property type="entry name" value="NUP88/NUP82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257">
        <property type="entry name" value="NUCLEOPORIN NUP84-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="831"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="744"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED21886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="892" mass="99119" checksum="9ADB593D28353DEC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1Z3</accession>
    <name>B8M1Z3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_086020</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Cytoplasmic vesicle</location>
            <location evidence="10 11">COPI-coated vesicle membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Golgi apparatus membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478334.1">
        <property type="nucleotide sequence ID" value="XM_002478289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1Z3"/>
    <dbReference type="FunCoup" id="B8M1Z3">
        <property type="interactions" value="1155"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M1Z3"/>
    <dbReference type="GeneID" id="8104567"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_086020"/>
    <dbReference type="eggNOG" id="KOG2635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019988_3_0_1"/>
    <dbReference type="InParanoid" id="B8M1Z3"/>
    <dbReference type="OMA" id="VQFRTHP"/>
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        <source>
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        <source>
            <dbReference type="RuleBase" id="RU366052"/>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="534" mass="59313" checksum="76C6890D96B100D0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8M218</accession>
    <name>B8M218_TALSN</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="3" type="ORF">TSTA_087150</name>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <dbReference type="PhylomeDB" id="B8M218"/>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08457"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED21482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1067" mass="125042" checksum="BA3BEFFF3CB9FB63" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8M233</accession>
    <name>B8M233_TALSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <dbReference type="NCBI Taxonomy" id="441959"/>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED21497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_087330"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082502_0_0_1"/>
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    </dbReference>
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            <end position="208"/>
        </location>
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        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
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        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
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        <location>
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            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="247" mass="25334" checksum="9875EC269CE5EAD7" modified="2009-03-03" version="1">MDLQGTPIGNSTGGTKAITKVTSDPASNISIQEGPGPVPNDSLAGESVRQGGAFRQNPNSEPLGVSGSKATFNNTNTSGATTLPSAPQAGARDSDRKERYPDALGGQGNYPGTHLPESGYAGGSTQAKRDMGIGGHQHQYNTTEHAQAGGSGSQSNAGTAPSYVTPVVQNVGNTKPHGTNIKEGGFDSDPKKNASFNSDIGTNNDPGRLAEQKFQKYTAESGANAAYTNPTVDANQPYGVLGSDQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8M241</accession>
    <name>B8M241_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spermidine synthase</fullName>
            <ecNumber evidence="6">2.5.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_087410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <dbReference type="NCBI Taxonomy" id="441959"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EED21505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002478423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M241"/>
    <dbReference type="FunCoup" id="B8M241">
        <property type="interactions" value="1001"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M241"/>
    <dbReference type="GeneID" id="8100870"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_087410"/>
    <dbReference type="eggNOG" id="KOG1562">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048199_1_0_1"/>
    <dbReference type="InParanoid" id="B8M241"/>
    <dbReference type="OMA" id="FLYHEMM"/>
    <dbReference type="OrthoDB" id="38125at2759"/>
    <dbReference type="PhylomeDB" id="B8M241"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.140.10:FF:000001">
        <property type="entry name" value="SPE3p Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000013">
        <property type="entry name" value="Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="entry name" value="Spermidine synthase, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030668">
        <property type="entry name" value="Spermi_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037959">
        <property type="entry name" value="MFS_SpdSyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002010">
        <property type="entry name" value="PRK00811.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558:SF11">
        <property type="entry name" value="SPERMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="SPERMIDINE/SPERMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000502">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="11"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED21505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="291" mass="33000" checksum="946A2F7EDA90E190" modified="2009-03-03" version="1">MSEITHPTIKDGWFSEASDMWPGQAMTLKVKEVLHHEKSQYQDVLVFESTDHGTVLVLDNVIQCTERDEFSYQEMITHLAMNSHPNPKKVLVIGGGDGGVLREVVKHESVEEAILCDIDEAVIRVSKKYLPGMSIGFQHPNVKVHIGDGFKFLADYKNEFDVIITDSSDPEGPAESLFQKPYFELLNGALREGGVITTQAENQWLHLQLITDLKKSCKEVFPVAEYAYTTIPTYPSGQIGFMVCCKDATRNVKEPLRTWSREEEEKLCRYYNADIHRASFVLPNFARKALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8M296</accession>
    <name>B8M296_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochondrial outer membrane protein (Sam35), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_087960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478523.1">
        <property type="nucleotide sequence ID" value="XM_002478478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M296"/>
    <dbReference type="STRING" id="441959.B8M296"/>
    <dbReference type="GeneID" id="8101088"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_087960"/>
    <dbReference type="eggNOG" id="KOG3028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055680_0_0_1"/>
    <dbReference type="InParanoid" id="B8M296"/>
    <dbReference type="OMA" id="RNAWLYT"/>
    <dbReference type="OrthoDB" id="198787at2759"/>
    <dbReference type="PhylomeDB" id="B8M296"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03078">
        <property type="entry name" value="GST_N_Metaxin1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021211">
        <property type="entry name" value="SAM35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF44">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN (SAM35), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17172">
        <property type="entry name" value="GST_N_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10806">
        <property type="entry name" value="SAM35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="3">
        <location>
            <begin position="92"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="2">
        <location>
            <begin position="239"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED21560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="311" mass="35020" checksum="6CB24CF74C9D7DB4" modified="2009-03-03" version="1">MTSETRADAASPVGTEHEAEPPRPTSSNAVPPKKLFGVPAPVKRIFDKFPLTTYEAEGIPGNVHTSGSPERNRLFVFIDPKQAAKGAPSFNPQCLRWQAYLKFVGIDFDLIPSNNHASPTGALPFLYAALPSGTKSPIPSNKLQKWAIEQVHCEEEQQLNIRFDVYASLIDHRIRNAWLHQLYLNALNFNQVARKRYINPATSSSAVQTALAVQLQQAARDELLKYSDYIDVNVLEADADNAFEALSVLLGDNDYFFNRIQPGLFDANVFAYTHLILDESMGWKYNQLAHSLSKYDNLLRHRRVLLQQYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2D5</accession>
    <name>B8M2D5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_088350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478562.1">
        <property type="nucleotide sequence ID" value="XM_002478517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2D5"/>
    <dbReference type="STRING" id="441959.B8M2D5"/>
    <dbReference type="GeneID" id="8106932"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_088350"/>
    <dbReference type="eggNOG" id="ENOG502S0VZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006331_0_0_1"/>
    <dbReference type="InParanoid" id="B8M2D5"/>
    <dbReference type="OMA" id="DYCFHVG"/>
    <dbReference type="OrthoDB" id="775571at2759"/>
    <dbReference type="PhylomeDB" id="B8M2D5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000013">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF70">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="181"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="599"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="479"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="493"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED21599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="979" mass="109930" checksum="089AB3CFD8DE9B1A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8M355</accession>
    <name>B8M355_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosducin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_092770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478994.1">
        <property type="nucleotide sequence ID" value="XM_002478949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M355"/>
    <dbReference type="STRING" id="441959.B8M355"/>
    <dbReference type="GeneID" id="8099455"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_092770"/>
    <dbReference type="eggNOG" id="KOG3171">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053880_0_0_1"/>
    <dbReference type="InParanoid" id="B8M355"/>
    <dbReference type="OMA" id="GIIEMMP"/>
    <dbReference type="OrthoDB" id="70588at2759"/>
    <dbReference type="PhylomeDB" id="B8M355"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02987">
        <property type="entry name" value="Phd_like_Phd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001200">
        <property type="entry name" value="Phosducin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051499">
        <property type="entry name" value="Phosducin-like_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052:SF1">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="84"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED22031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="296" mass="33139" checksum="98090A7F86DCA09D" modified="2009-03-03" version="1">MSSAQDEFDRLIQANRDSSRTHPEDRDQSDNDSSPAEEHNHSAVADDHYELSDADSDYGDHVKRDNDAMVSRTATYTVPTTVFEANTGPKGVIADAQSFERARKKSFRRTLLSAAGLESHSRLFGVSNNITSQQQQQPIQTASSSPPSDEDEEFMRRWRESRLQELQERSQRRPSPSKRVYGRVDTVDAEGYLNAIERVASDTVVVVCIYDPESSVSSQVEDAIEVVARKQSTTRFVKLHHEIAEMSHIEAPALLAYKAGDVICTLVDIPRQIPRGGEISANSIEDLFKQYVTSFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8M534</accession>
    <name>B8M534_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_029170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480074.1">
        <property type="nucleotide sequence ID" value="XM_002480029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M534"/>
    <dbReference type="STRING" id="441959.B8M534"/>
    <dbReference type="GeneID" id="8099036"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_029170"/>
    <dbReference type="eggNOG" id="KOG0683">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017290_0_1_1"/>
    <dbReference type="InParanoid" id="B8M534"/>
    <dbReference type="OMA" id="NIMTFRL"/>
    <dbReference type="OrthoDB" id="77835at2759"/>
    <dbReference type="PhylomeDB" id="B8M534"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006576">
        <property type="term" value="P:biogenic amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000013">
        <property type="entry name" value="Glutamine synthetase bacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000005">
        <property type="entry name" value="Probable glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785">
        <property type="entry name" value="GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785:SF12">
        <property type="entry name" value="TYPE-1 GLUTAMINE SYNTHETASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS catalytic" evidence="8">
        <location>
            <begin position="123"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED19640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="487" mass="54163" checksum="42D7D9DD08763D6A" modified="2009-03-03" version="1">MSTPAETDVTAENVATLLQYDTKVKLAGVDADGILRGKLVSKKKFLSIAEAGFGFCSVIFGWDMHDRTYFKELSISNKENGYRDLLAIPDLKSFRRIPWEDNVPFFLVSFFDPETKRPISACPRNLLQASVNKLASLDYKAMAGAEYEFYQFRVPHDTSSSERNSSATAAFLKNNPVESLPPLTEGMFGYSITRPVHNQDYYYGIFDACEQFRCDLEGWHTESGPGVFEAALQFGEIKEMADRAGLFKYVVKSLGSKHGITPAFMAKPREGLPGNSGHMHVSIVSKEGKNLFARDTVDPSPPYPEVAHLSDMGRHFLAGLLEGLPDIMPILAPTINSYKRLVENFWAPVTVSWGLEHRAASIRLISPPTASAKATRFEVRVPGADANPHYVLAAILATGWRGVEKKLEIPLSPLGKGEDTGSTSDKGARLAKSLKEANEIFRRPGSIAREVFGDEFVDHFSGTREHEIVLWEEAVTDWEVRRYIETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5A4</accession>
    <name>B8M5A4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="7">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25 26">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">TSTA_029820</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="32" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Chromosome</location>
            <location evidence="4">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="7"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480144.1">
        <property type="nucleotide sequence ID" value="XM_002480099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5A4"/>
    <dbReference type="FunCoup" id="B8M5A4">
        <property type="interactions" value="899"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M5A4"/>
    <dbReference type="GeneID" id="8106549"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_029820"/>
    <dbReference type="eggNOG" id="KOG3087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063953_1_0_1"/>
    <dbReference type="InParanoid" id="B8M5A4"/>
    <dbReference type="OMA" id="HKLYMEY"/>
    <dbReference type="OrthoDB" id="3399at2759"/>
    <dbReference type="PhylomeDB" id="B8M5A4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000603">
        <property type="entry name" value="EKC/KEOPS complex subunit bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000845">
        <property type="entry name" value="Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06293">
        <property type="entry name" value="Kdo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="22" id="KW-0010">Activator</keyword>
    <keyword evidence="19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17 31" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="20" id="KW-0779">Telomere</keyword>
    <keyword evidence="23" id="KW-0804">Transcription</keyword>
    <keyword evidence="21" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="30">
        <location>
            <begin position="18"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="EED19710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="293" mass="32972" checksum="51D6363929909C81" modified="2009-03-03" version="1">MNTEYTPPPLPPPFSHTTPPPILLAQGAEARLYKTTFLTPDTPAALKIRPTKPYRHELLDRRLTRQRVLHEARCLMKLVREGVSVPAILALDWDPATPADGQRSVGAWLMMEWIEGLAVKHILERWEKWMKKSINTATSEDSYFNKEEEEAKVKELMKRIGRTVGSMHKVGVVHGDLTTSNLILRPPVDSSTPSDITESPSMAGDIVLIDFGLASTSSHEEDRAVDLYVLERAFGSTHPMTENFFSVVLDGYSESFKGAKLVLKKLEDVRMRGRKRKNRPNASLGLNAEEDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5R7</accession>
    <name>B8M5R7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_032950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480478.1">
        <property type="nucleotide sequence ID" value="XM_002480433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5R7"/>
    <dbReference type="STRING" id="441959.B8M5R7"/>
    <dbReference type="GeneID" id="8105034"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_032950"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_1_2_1"/>
    <dbReference type="InParanoid" id="B8M5R7"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="PhylomeDB" id="B8M5R7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF22">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877564" description="FAD-binding PCMH-type domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="61"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED20044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="489" mass="52493" checksum="9F8B48C19ECFB4AF" modified="2009-03-03" version="1">MSGRVLFLVVLFSSLGMVYSLALANAMACGALAILMPEKVFNSNTASYTAALTSYFSRQEQEVKPECVVIPQSTNDVSEIVATMTAFAWIGAQFAVRGGGHSIYAGAANIQGGVTIDLSSLNEVTVSPDKSTVDLGPGGKWGAVYEVLDPLQITVSGGRDSDVGVGGYLLGGGMSYIGPLAGWACDNVVEYEVVLADGKVVNVNNDSYPDLFLALKGGGNNFGIVTRFTLKTHPLGNFWGGFLVYPITSIGQQIDSLSKFLGTQPYDPYAAMIQSWGYSSEMTVISDGIYYTQNVQSTPAVYQDFVDNSTLMQSSLRTSNMSSFAAETDKYQAYSMRQGYYTTSFLHTPSIYSTIYDIFNTSLTSVSKVQGINWYLTIQATPALNGTNSLGLKPGNARLINVLLTTCWSNASDDAAVAAAAKSLISSIESATRAAGVYQNYKYYNYADISQEVISGYGSASVEELRTVSKKYDVYGVFQNSVPGGFKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8M614</accession>
    <name>B8M614_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_023490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479448.1">
        <property type="nucleotide sequence ID" value="XM_002479403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M614"/>
    <dbReference type="GeneID" id="8109531"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_023490"/>
    <dbReference type="eggNOG" id="ENOG502SWX9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032318_0_0_1"/>
    <dbReference type="InParanoid" id="B8M614"/>
    <dbReference type="OMA" id="LRWISEG"/>
    <dbReference type="OrthoDB" id="4213040at2759"/>
    <dbReference type="PhylomeDB" id="B8M614"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="616" mass="71032" checksum="DFF6DBDD5ED47644" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6E1</accession>
    <name>B8M6E1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Phosphoethanolamine N-methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_026270</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479750.1">
        <property type="nucleotide sequence ID" value="XM_002479705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6E1"/>
    <dbReference type="FunCoup" id="B8M6E1">
        <property type="interactions" value="653"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M6E1"/>
    <dbReference type="GeneID" id="8098908"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_026270"/>
    <dbReference type="eggNOG" id="KOG2126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004298_1_0_1"/>
    <dbReference type="InParanoid" id="B8M6E1"/>
    <dbReference type="OMA" id="YPSFDIF"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="PhylomeDB" id="B8M6E1"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16023">
        <property type="entry name" value="GPI_EPT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037675">
        <property type="entry name" value="PIG-O_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="572"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="609"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="637"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="666"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="709"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="741"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="780"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="936"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1014"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1045"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="973"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED19316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1081" mass="118805" checksum="4289F86FFC0E3F13" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6F8</accession>
    <name>B8M6F8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_026430</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="8"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479767.1">
        <property type="nucleotide sequence ID" value="XM_002479722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6F8"/>
    <dbReference type="FunCoup" id="B8M6F8">
        <property type="interactions" value="452"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M6F8"/>
    <dbReference type="GeneID" id="8098924"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_026430"/>
    <dbReference type="eggNOG" id="KOG3396">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072095_0_0_1"/>
    <dbReference type="InParanoid" id="B8M6F8"/>
    <dbReference type="OMA" id="NQRYDWI"/>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="PhylomeDB" id="B8M6F8"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000048">
        <property type="entry name" value="Glucosamine 6-phosphate N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="9">
        <location>
            <begin position="82"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED19333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="224" mass="25047" checksum="D5CB7C21ED1288D6" modified="2009-03-03" version="1">MTTDLYSVPASNGIESTNLLHIKEDVDATATNSNGTHKTTNGTIIHKPQLENGTKSAEEEEEPLFSPSLISAEIQSVLPEGYSARPLRRSDFHLGYLDVLRVLTTVGDISEAMWNERYNYLYKRNDEYYMIVICDGTGKIVGTGSLIVERKFIHTLGLVGHIEDIAVAQDQQGKKLGLRIIQTLDYVAEKVGCYKTILDCSEINEGFYIKCGFKRAGLEMAHYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6R7</accession>
    <name>B8M6R7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_033790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480571.1">
        <property type="nucleotide sequence ID" value="XM_002480526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6R7"/>
    <dbReference type="GeneID" id="8097796"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_033790"/>
    <dbReference type="HOGENOM" id="CLU_2098473_0_0_1"/>
    <dbReference type="InParanoid" id="B8M6R7"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED20137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="12943" checksum="84EE89BDB4C51F11" modified="2009-03-03" version="1">MNSSASRQSRYDSVRIMLSESSADWSSHYRDGQREPLQTAVRLGDLEMCSLLISHGKADPLSALPYDSEPQVGLKDNCPEDEEKAVVQILQLLCEYADREVSHQGNGSKVEFKALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7H1</accession>
    <name>B8M7H1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Probable electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial</fullName>
            <ecNumber evidence="6">1.5.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Electron-transferring-flavoprotein dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">TSTA_028140</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Accepts electrons from ETF and reduces ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + oxidized [electron-transfer flavoprotein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24052"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.5.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ETF-QO/FixC family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.1" evidence="6"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479958.1">
        <property type="nucleotide sequence ID" value="XM_002479913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7H1"/>
    <dbReference type="FunCoup" id="B8M7H1">
        <property type="interactions" value="722"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M7H1"/>
    <dbReference type="GeneID" id="8108330"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_028140"/>
    <dbReference type="eggNOG" id="KOG0106">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2415">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009667_1_0_1"/>
    <dbReference type="InParanoid" id="B8M7H1"/>
    <dbReference type="OMA" id="INTSWTW"/>
    <dbReference type="OrthoDB" id="437331at2759"/>
    <dbReference type="PhylomeDB" id="B8M7H1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12339">
        <property type="entry name" value="RRM2_SRSF1_4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000015">
        <property type="entry name" value="Electron transfer flavoprotein-ubiquinone oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040156">
        <property type="entry name" value="ETF-QO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049398">
        <property type="entry name" value="ETF-QO/FixC_UQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007859">
        <property type="entry name" value="ETF-QO/FixX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617:SF107">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21162">
        <property type="entry name" value="ETFQO_UQ-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05187">
        <property type="entry name" value="Fer4_ETF_QO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="16" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14 27" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="23" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="17 27" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="26">
        <location>
            <begin position="599"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="25">
        <location>
            <begin position="802"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="25">
        <location>
            <begin position="898"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="676"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="754"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="971"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="24">
        <location>
            <begin position="760"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="974"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1014"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1041"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="1073"/>
            <end position="1083"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00032754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00052682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00068100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="EED19524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1100" mass="123035" checksum="A7395DB5DED1F8CF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7N3</accession>
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        <submittedName>
            <fullName evidence="7">PQ loop repeat protein</fullName>
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        <name evidence="7" type="ORF">TSTA_028680</name>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EED19586.1"/>
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    <dbReference type="AlphaFoldDB" id="B8M7N3"/>
    <dbReference type="GeneID" id="8098987"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_028680"/>
    <dbReference type="eggNOG" id="ENOG502RZDU">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_033734_1_0_1"/>
    <dbReference type="InParanoid" id="B8M7N3"/>
    <dbReference type="OMA" id="FVIYFPR"/>
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    <dbReference type="PhylomeDB" id="B8M7N3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF11">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
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        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED19586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="316" mass="34672" checksum="1E9CD47CEC54C554" modified="2009-03-03" version="1">MGSISPQCRDLELPHYMNFNFILSLLILVGILLSYLPQHIRIIRLRSSFGLSPYFVLLGTTSGTAAFANILVLPRSAHDAACCREISGVSCFAGLLGIFQVGVQCLSFYVILFLFLIYFPRATSLVDPTTSAESENERNGNGNADIEDTDDKQPSYATAVVVALICLVHAAIVLIISLVVALKYPDHLQAWANILGIMSAVLASIQYFPQIWTTFRLQKVGSLSIPMMCIQTPGSLVWAASLAQRLGAEGWSAWGVYVITALLQGTLLVMGVYFEYLGPKKDLIEHPFMADETQPAAEEVQDQQATEHTPLLSEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7Q1</accession>
    <name>B8M7Q1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CorA family metal ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_028860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002479993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7Q1"/>
    <dbReference type="GeneID" id="8099005"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_028860"/>
    <dbReference type="eggNOG" id="ENOG502SS3N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042316_0_0_1"/>
    <dbReference type="InParanoid" id="B8M7Q1"/>
    <dbReference type="OMA" id="NLITLEH"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="PhylomeDB" id="B8M7Q1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED19604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="45341" checksum="4ADE02B6A8E145B8" modified="2009-03-03" version="1">MNRDAGTFLEDKSQALDLLEQCWNIDMDDVALLTSHLVSSYHSRIVKVNGDVCLDISYNIREDILYDRNNISSLESTLTVNVIKPTDLRVQHEYESLYFRHNITTGQTTYILPNASREYRGLLYTLGRRFSERASSMHPFSLHAVILFQSLAARSVQIDDLYRRLLWIETQIYQGSIFQGTDSEKFIRYIQLSHKLSRNLITLEHRNERDRSHIEKLLDDHKRLYRLIKQSSPLSERHIDMNTHEHVRDSLLSLKDLAHDQDRQIINSQRKTQLFITLLYNLITGHDSGINLKIASETAKVAHEAKKDSTSMKIIAGVTMVYLPATFVCSLFGTNFVALDTNASEPSFVVSKLWWVYIAFAVPLTAVTIMGFLVWRRWRRGQVTLEDRYQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8B6</accession>
    <name>B8M8B6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-ketoglutarate-dependent sulfonate dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_036540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480863.1">
        <property type="nucleotide sequence ID" value="XM_002480818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8B6"/>
    <dbReference type="STRING" id="441959.B8M8B6"/>
    <dbReference type="GeneID" id="8101925"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_036540"/>
    <dbReference type="eggNOG" id="ENOG502RYJ5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010103_3_1_1"/>
    <dbReference type="InParanoid" id="B8M8B6"/>
    <dbReference type="OMA" id="YCEAIRA"/>
    <dbReference type="OrthoDB" id="2684236at2759"/>
    <dbReference type="PhylomeDB" id="B8M8B6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365">
        <property type="entry name" value="ENOLASE (DUF1399)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365:SF7">
        <property type="entry name" value="GLYCINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07173">
        <property type="entry name" value="GRDP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="768" mass="84312" checksum="4A3ADDB8CA11C5C6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8M907</accession>
    <name>B8M907_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-containing redox enzyme family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_111430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481293.1">
        <property type="nucleotide sequence ID" value="XM_002481248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M907"/>
    <dbReference type="STRING" id="441959.B8M907"/>
    <dbReference type="GeneID" id="8109823"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_111430"/>
    <dbReference type="eggNOG" id="ENOG502QVWE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003680_0_0_1"/>
    <dbReference type="InParanoid" id="B8M907"/>
    <dbReference type="OMA" id="EEAKWWL"/>
    <dbReference type="OrthoDB" id="10057598at2759"/>
    <dbReference type="PhylomeDB" id="B8M907"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14518">
        <property type="entry name" value="Haem_oxygenas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01236">
        <property type="entry name" value="Haem_oxygenase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED17301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="717" mass="80320" checksum="DC4AFBA1C2ED2127" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9H7</accession>
    <name>B8M9H7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldo/keto reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_115350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481729.1">
        <property type="nucleotide sequence ID" value="XM_002481684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9H7"/>
    <dbReference type="STRING" id="441959.B8M9H7"/>
    <dbReference type="GeneID" id="8101345"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_115350"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_1"/>
    <dbReference type="InParanoid" id="B8M9H7"/>
    <dbReference type="OMA" id="FEWEYES"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="PhylomeDB" id="B8M9H7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19143">
        <property type="entry name" value="AKR_AKR6C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF6">
        <property type="entry name" value="VIC POTASSIUM ION CHANNEL, BETA SUBUNIT (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="27"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED17737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="355" mass="39844" checksum="82DDAC2062AC1F92" modified="2009-03-03" version="1">MTTELPKDLPKMEYRHLGNSGLLVSVISLGGWLTYGGHVEDEKTFSCMKAAYDAGINFFDTAEGYAGGQSEVVMGKAIKKFGWKQRDLVISTKLYFGQDNAKDPENPLNNRGLSRKHIIEGLNQSLARLDLPYVDIVYAHRPDRTTPMHEIVRAFNYLIDQGKTFYWGTSEWSASEIAEAWRIADKLGLIGPVVEQPQYNLLERQRVEKEYRWLYAEHGLGLTVFSPLKQGILTGKYNNVEAPPPGSRLTEADGKMAYVTQFAKTWGNETWKKNLAVVANLKPIAEELNVTLAQLSLAWALKNPNVSSLITGASRPEQVFENVRAVEVVKKLTPEIMERIEKAAETAPPAEPLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9S6</accession>
    <name>B8M9S6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isoflavone reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_118470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482070.1">
        <property type="nucleotide sequence ID" value="XM_002482025.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482071.1">
        <property type="nucleotide sequence ID" value="XM_002482026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9S6"/>
    <dbReference type="STRING" id="441959.B8M9S6"/>
    <dbReference type="GeneID" id="8099771"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_118470"/>
    <dbReference type="eggNOG" id="ENOG502QPMY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044876_6_0_1"/>
    <dbReference type="InParanoid" id="B8M9S6"/>
    <dbReference type="OMA" id="TPYPENM"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050608">
        <property type="entry name" value="NmrA-type/Isoflavone_red_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43349:SF93">
        <property type="entry name" value="ISOFLAVONE REDUCTASE HOMOLOG P3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43349">
        <property type="entry name" value="PINORESINOL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED18078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="326" mass="36580" checksum="022E43663C0DDD5D" modified="2009-03-03" version="1">MATKVLLIGATGETGRSIANGLLNAGGFEVYAFTRAASVHKPQLLDLEKKGVIIRQCDLTAPKEELAEALKGIDIVVSSVGPSDQHIQHNIATAAKVAGVKRFIPCGFITICAPGGIMWLRDEKEKVYNHIKQIKLPYTIIDIGWWYQIATPRLPSGKIDYAMTTSNDELIGDGRTPSSFTDLRDIGKYVAKIIVDPRTENKMVFAYNVVMSPAEIFDTVERLSGEKVERRYIPEETVHKRVAETRASSETYPFEPTKFTARFVAEYQLSWGIRGDNVPEYAKYLGYLDAKELYPDFKPILFEEYVQELLHGTATGVYTDRISRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9X7</accession>
    <name>B8M9X7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_118930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482121.1">
        <property type="nucleotide sequence ID" value="XM_002482076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9X7"/>
    <dbReference type="STRING" id="441959.B8M9X7"/>
    <dbReference type="GeneID" id="8108567"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_118930"/>
    <dbReference type="eggNOG" id="ENOG502SHFM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038717_1_0_1"/>
    <dbReference type="InParanoid" id="B8M9X7"/>
    <dbReference type="OMA" id="EISHARP"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="PhylomeDB" id="B8M9X7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="398" mass="44017" checksum="158F948374FB428E" modified="2009-03-03" version="1">MRATYSIFIALSAISIPLLWFPMLLNGTLDDISEAIENNVLPDGTPLKTKYSGVSFFDNILSILVAFFYALANGSYLGARLMLADLGATLHVALGWMVVESIRNGKKPWYLSLPGLLGVLWNVAGAGIVLPLYCLIHIQTPMNDYKISVSHSISLIPAMLVSSIPFCLMIIPPKDGNYSADQHQNTIAVFQFAPLIWMAGQYTFSFLLSPFSKLAKLGLQNRSRTEISHARPRRSEIYIQAAQLFFAIYSALVHLLCVSISFFSSDPSVTILRVFIPNPIGVNRESPQRLTQAAILFLQYDWLVICLTAVLYSYLLLEPEILSTSKQARWKSTKSLLVRLLTFLPISNSLSSIIGLVAFTILLGPSTVVSLALWQCEGRLFPGPGVVEPEGRSIIKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8MA36</accession>
    <name>B8MA36_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_121090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482357.1">
        <property type="nucleotide sequence ID" value="XM_002482312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MA36"/>
    <dbReference type="STRING" id="441959.B8MA36"/>
    <dbReference type="GeneID" id="8102448"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_121090"/>
    <dbReference type="eggNOG" id="ENOG502S3V7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_731785_0_0_1"/>
    <dbReference type="InParanoid" id="B8MA36"/>
    <dbReference type="OMA" id="YKFPMWV"/>
    <dbReference type="OrthoDB" id="5593235at2759"/>
    <dbReference type="PhylomeDB" id="B8MA36"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="388" mass="44347" checksum="619FF45F95F0705C" modified="2009-03-03" version="1">MAYTDEKLHNLEENIEPIYAKHSQHRRSKIFLIALLGGTITFYSLFGIILLCFYSDATLLALITNPHFNHKYNHLQNQWINTKSSIALDEKPRGVNIAAVVEYRNWERSSILNCYLRRNLVEYGGLLDEVVFIPETTDREHLEWLYETVNKSESYSIRPYFFPAADTKDIYIKIDGDVVYIEDNVIPTIINTKLQHPETGIVSANVIHQPAVAEFHRRAGVVLPQLLDIKSLSQDSKTSGRNWIPFLSYWRNMLESWFCQQRPAPSSSSSIYLVSNSASATEQYTWLSQAQQHNSFLHHLERDELQSYKFPLWKNPPGEISGAFVVLPGNSNASNINSSTLSQQRDVLIDGKGVVSHYDDAAGKEGLDVTNILNRYRKYAEDHACFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8MA68</accession>
    <name>B8MA68_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_121400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482389.1">
        <property type="nucleotide sequence ID" value="XM_002482344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MA68"/>
    <dbReference type="GeneID" id="8099380"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_121400"/>
    <dbReference type="HOGENOM" id="CLU_1511589_0_0_1"/>
    <dbReference type="InParanoid" id="B8MA68"/>
    <dbReference type="PhylomeDB" id="B8MA68"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="178" mass="19741" checksum="81E2BAB586DE5898" modified="2009-03-03" version="1">MTLRAKIARVQQICTSYRRRVIQSCDDGNPQGSEEEKTCKVGEESTQASKKPQDVVTYVYDSELGQQVQGWACEYNMCPGPLGPSVTPQGDGVKADHLIRCVLTQKVTRQRAQQAVLNEAPRQEPSEGLRQLVAAAQIEDAFCMRVDKDLSEGDSTRLHYGRTSDGVLLYKGRILVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAH2</accession>
    <name>B8MAH2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_112290</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481388.1">
        <property type="nucleotide sequence ID" value="XM_002481343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAH2"/>
    <dbReference type="STRING" id="441959.B8MAH2"/>
    <dbReference type="GeneID" id="8105695"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_112290"/>
    <dbReference type="eggNOG" id="KOG1097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022829_2_1_1"/>
    <dbReference type="InParanoid" id="B8MAH2"/>
    <dbReference type="OMA" id="FQACFGP"/>
    <dbReference type="OrthoDB" id="7202371at2759"/>
    <dbReference type="PhylomeDB" id="B8MAH2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000017">
        <property type="entry name" value="Adenosine deaminase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF39">
        <property type="entry name" value="ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="10">
        <location>
            <begin position="231"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED17396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="571" mass="66112" checksum="1D67AB75B1067DB6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAM2</accession>
    <name>B8MAM2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_112780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481438.1">
        <property type="nucleotide sequence ID" value="XM_002481393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAM2"/>
    <dbReference type="GeneID" id="8105743"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_112780"/>
    <dbReference type="HOGENOM" id="CLU_080664_2_1_1"/>
    <dbReference type="InParanoid" id="B8MAM2"/>
    <dbReference type="OMA" id="QMAGRNI"/>
    <dbReference type="OrthoDB" id="1601230at2759"/>
    <dbReference type="PhylomeDB" id="B8MAM2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="126" mass="14760" checksum="8C0A42B9D6EFC958" modified="2009-03-03" version="1">MIEFKEEVTAEQVEDVYNRWSSLKGLCVRSDSQKPYITKQMAGRNISLEKLTGGFTHIFIEEFKNEQDRNYYLKKDPAHRDFGKIVEPLVKSAQSVQNDDDIYFDNKSWYGSRCRTLSEPADADYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8MB48</accession>
    <name>B8MB48_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutathione hydrolase</fullName>
            <ecNumber evidence="3">2.3.2.2</ecNumber>
            <ecNumber evidence="3">3.4.19.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Gamma-glutamyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Gamma-glutamyltranspeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_124680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="3"/>
    <dbReference type="EC" id="3.4.19.13" evidence="3"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482741.1">
        <property type="nucleotide sequence ID" value="XM_002482696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MB48"/>
    <dbReference type="FunCoup" id="B8MB48">
        <property type="interactions" value="177"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MB48"/>
    <dbReference type="MEROPS" id="T03.011"/>
    <dbReference type="GeneID" id="8100247"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_124680"/>
    <dbReference type="eggNOG" id="KOG2410">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014813_4_0_1"/>
    <dbReference type="InParanoid" id="B8MB48"/>
    <dbReference type="OMA" id="GFMLVHL"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="PhylomeDB" id="B8MB48"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000008">
        <property type="entry name" value="Gamma-glutamyltranspeptidase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF62">
        <property type="entry name" value="GLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="441"/>
            <end position="443"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="493"/>
            <end position="494"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="516"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED18749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="613" mass="66188" checksum="855602529EB55F37" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MC59</accession>
    <name>B8MC59_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Diaminohydroxyphosphoribosylamino-pyrimidine deaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_122380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482497.1">
        <property type="nucleotide sequence ID" value="XM_002482452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MC59"/>
    <dbReference type="FunCoup" id="B8MC59">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MC59"/>
    <dbReference type="GeneID" id="8097703"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_122380"/>
    <dbReference type="eggNOG" id="KOG1018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051532_1_1_1"/>
    <dbReference type="InParanoid" id="B8MC59"/>
    <dbReference type="OMA" id="ACDTIYN"/>
    <dbReference type="OrthoDB" id="2529286at2759"/>
    <dbReference type="PhylomeDB" id="B8MC59"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF109">
        <property type="entry name" value="RIBOSOMAL LYSINE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="35630" checksum="4814192D921D60F3" modified="2009-03-03" version="1">MSESLLNFLSSIGEEVVDAEEESFLLFSRTIPSNNLGFVNSRTTAIDLSIHNIDYTIRQSPTLLSSTRDGGTTGAVLWKITPLFASWISAVTTNPFWSGILGADTSVIELGCGISGLVALTLAPLVRKYVATDQEYVRRFFGMNIEENAHSVHSSSKRGSSKKGHRRENTKRSKSNNIQFIPLDWELDIPSNQTLHNTNNSDTDDGPGSENGFDIIISCDCIYNEALIPCFVRTCADICNLRSTQPEQVEPKNPTMAIIAQQQRSPDVFEAWLKESLKYFRVWRVEKFSSTVAGPEGDESGLGDGSGYVVHVLVLREGLRTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCP6</accession>
    <name>B8MCP6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD-dependent epimerase/dehydratase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_126560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the avfA family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482940.1">
        <property type="nucleotide sequence ID" value="XM_002482895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCP6"/>
    <dbReference type="STRING" id="441959.B8MCP6"/>
    <dbReference type="GeneID" id="8099083"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_126560"/>
    <dbReference type="eggNOG" id="ENOG502SM0C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090039_1_0_1"/>
    <dbReference type="InParanoid" id="B8MCP6"/>
    <dbReference type="OMA" id="DNIPGCH"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="PhylomeDB" id="B8MCP6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="OXIDOREDUCTASE MDPK"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
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    </dbReference>
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        <location>
            <begin position="11"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED18948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="260" mass="28839" checksum="BE69A75D9B72B9F3" modified="2009-03-03" version="1">MAISNTYAVLGSTGNCGTALIRNLLNKPDTRIHAYCRNRSKLLRLLPDFKEGGRVKIFEGSIHNIELLTSCLRNCRAVFLVVSTNDNIPGCRLAQDTAAAVIESLQKIKQGSTDSNEIRKMPKLVLLSSATIDDHFSRHVPYLLRLILLRSASHVYNDLIETEKLLRAQEDWLTTIFIKPGALSVDIQRGHALSLTDEESPLSYLDLAAAMIEAADDESGSYDMKDAKFPTGTPMCIFMGLLRHFFPLLHPYLPLNTGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8MD32</accession>
    <name>B8MD32_TALSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_113760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481550.1">
        <property type="nucleotide sequence ID" value="XM_002481505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MD32"/>
    <dbReference type="GeneID" id="8101688"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_113760"/>
    <dbReference type="HOGENOM" id="CLU_2413993_0_0_1"/>
    <dbReference type="InParanoid" id="B8MD32"/>
    <dbReference type="OMA" id="ASKYRTV"/>
    <dbReference type="OrthoDB" id="4497633at2759"/>
    <dbReference type="PhylomeDB" id="B8MD32"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="100" mass="11290" checksum="5349BAC0F7C21434" modified="2009-03-03" version="1">MPKDSHVLPSKPIESHPVPKKAFGRVLDDDRPIDDFENTVRREEAQKLAEERGPSPPNRAAARHPPDHPHAPHQPNGREGTTSSKYRSEAATIEHFILYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8MD41</accession>
    <name>B8MD41_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beige/BEACH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_113830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    <dbReference type="GeneID" id="8101695"/>
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    </dbReference>
    <dbReference type="eggNOG" id="KOG1788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000175_2_0_1"/>
    <dbReference type="InParanoid" id="B8MD41"/>
    <dbReference type="OMA" id="EMSNFHY"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="PhylomeDB" id="B8MD41"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD repeat and FYVE domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056252">
        <property type="entry name" value="Alfy-like_Arm-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108:SF4">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23295">
        <property type="entry name" value="Arm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="6">
        <location>
            <begin position="1705"/>
            <end position="1834"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="5">
        <location>
            <begin position="1873"/>
            <end position="2168"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="2298"/>
            <end position="2339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1606"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1654"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1658"/>
            <end position="1670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED17566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="2487" mass="281229" checksum="85EEEAB670DCD144" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B8MD52</accession>
    <name>B8MD52_TALSN</name>
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        <submittedName>
            <fullName evidence="6">Transcription factor (SPT8), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_113920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481569.1">
        <property type="nucleotide sequence ID" value="XM_002481524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MD52"/>
    <dbReference type="FunCoup" id="B8MD52">
        <property type="interactions" value="362"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MD52"/>
    <dbReference type="GeneID" id="8109154"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_113920"/>
    <dbReference type="eggNOG" id="ENOG502QS8F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010934_1_0_1"/>
    <dbReference type="InParanoid" id="B8MD52"/>
    <dbReference type="OMA" id="WDRRQPN"/>
    <dbReference type="OrthoDB" id="10260946at2759"/>
    <dbReference type="PhylomeDB" id="B8MD52"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900237">
        <property type="term" value="P:positive regulation of induction of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000927">
        <property type="entry name" value="Transcription factor (SPT8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057544">
        <property type="entry name" value="Beta-prop_SPT8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
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        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23798">
        <property type="entry name" value="Beta-prop_SPT8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="5">
        <location>
            <begin position="101"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="221"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="5">
        <location>
            <begin position="373"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="281"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
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            <begin position="56"/>
            <end position="76"/>
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            <begin position="294"/>
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    </feature>
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            <begin position="372"/>
            <end position="387"/>
        </location>
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        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="419"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23798"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED17577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="624" mass="67490" checksum="3407922A569E705D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8MD61</accession>
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        </submittedName>
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        <name evidence="4" type="ORF">TSTA_114010</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
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    <dbReference type="GeneID" id="8109163"/>
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    <dbReference type="OrthoDB" id="1888931at2759"/>
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    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED17586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="293" mass="31463" checksum="DC6BD2C9A289AC43" modified="2009-03-03" version="1">MAGSPLDQNAVFVHDNSVPPVHTSLFALFSLKGKTAIVTGGGAGIGLAVAQGLAEAGADIALFYNTNEKAPERAAEIEKKYGVKAKAYQADLRDQKKAEATINEAVKDFGRLDVFIANAGIPWTQGATVDGPIQHYLDVVQTDLDATWYCARAAAAHWRRQKEEGTDVNGNKLENFTYGSFVATASMSGHIVNIPQLQAPYNAAKAGVRHLVKSLAVEWPKFARANTISPGYIATEISNFIPKETHDLWKSKIPMGREGMPEELKGAFLYLASDASSYTTGTDIIVDGGYCAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDF8</accession>
    <name>B8MDF8_TALSN</name>
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        <recommendedName>
            <fullName evidence="1">Phosphoribosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_117070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED17921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="441959.B8MDF8"/>
    <dbReference type="GeneID" id="8102099"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_117070"/>
    <dbReference type="eggNOG" id="ENOG502SH5I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1462269_0_0_1"/>
    <dbReference type="InParanoid" id="B8MDF8"/>
    <dbReference type="OrthoDB" id="5416609at2759"/>
    <dbReference type="PhylomeDB" id="B8MDF8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
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    </dbReference>
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        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="1">
        <location>
            <begin position="47"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="185" mass="20824" checksum="17253CBD3AD2A617" modified="2009-03-03" version="1">MLVLDADRTLTAEDTVKLFWEAVLVTAFPLDIPMLKKANKFTVDVFIRGQRKQNIDVIDPTDRTSAKLLKTAMRDARNNSLILYEAHRRGHFTDGYRLFHEDRTLIVSLMRVGGPMAHGAWDMFPSAIYFQAKNPTDVKLGHLDGQINILLVDLVINSGKSIAEFVQHICNLHATIRIVVVASVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDP2</accession>
    <name>B8MDP2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_120210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482263.1">
        <property type="nucleotide sequence ID" value="XM_002482218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MDP2"/>
    <dbReference type="STRING" id="441959.B8MDP2"/>
    <dbReference type="GeneID" id="8101100"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_120210"/>
    <dbReference type="eggNOG" id="ENOG502QS8Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_402890_0_0_1"/>
    <dbReference type="InParanoid" id="B8MDP2"/>
    <dbReference type="OMA" id="DPQMKEM"/>
    <dbReference type="OrthoDB" id="4188028at2759"/>
    <dbReference type="PhylomeDB" id="B8MDP2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="610"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="683" mass="73747" checksum="48009A0D283F1749" modified="2009-03-03" version="1"> </sequence>
</entry>
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    <accession>B8MEC7</accession>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED16554.1"/>
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    <dbReference type="GeneID" id="8106406"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_016330"/>
    <dbReference type="eggNOG" id="ENOG502SKXF">
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    <dbReference type="PhylomeDB" id="B8MEC7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
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        <property type="entry name" value="Fungal_Metabolite_Diox"/>
    </dbReference>
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        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563">
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        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
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        <source>
            <dbReference type="EMBL" id="EED16554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="311" mass="34667" checksum="370D769FC1AA6474" modified="2009-03-03" version="1">MHQLLTNMPSNERPQIKMATTTVQDDITTVHLSPDEVSTKTLTSHNLQAAVTALHNDGIVVLNNAVDTSHLNKLNSRMIPEAQALYAKSSTHRNFGPGTGNIQQEPVLEDGYIFSDIIANPFAAQVVECMLGPKPALRFHSANTAFKATDRQPPHIDVHFDFPRGVPFGYCVNINLVDTSPRNGATEVWPGTHLNASIDDMSGEEAGIRKDLTEERRKVRPPVQPSLPKGSLIIRDFRLWHAGRPNQTDDPRVMIVTVLFPKWYRSNLEIILPESVKGKIDWGSLNPKVKWVPDGYDYLHGAHDHDFALLP</sequence>
</entry>
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            <fullName evidence="5">Integral membrane channel protein, putative</fullName>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="PhylomeDB" id="B8MER5"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <end position="347"/>
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            <end position="485"/>
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        <location>
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            <end position="515"/>
        </location>
    </feature>
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            <end position="545"/>
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        <location>
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            <end position="598"/>
        </location>
    </feature>
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        <location>
            <begin position="87"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="4">
        <location>
            <begin position="336"/>
            <end position="641"/>
        </location>
    </feature>
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        <location>
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            <end position="21"/>
        </location>
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        <location>
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        </location>
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        <location>
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        <location>
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        </location>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="854"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED16948.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="997" mass="112846" checksum="3749FBC0C9D3AEE8" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MF46</accession>
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        </recommendedName>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
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            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="441959.B8MF46"/>
    <dbReference type="GeneID" id="8104101"/>
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    <dbReference type="eggNOG" id="ENOG502SERX">
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    <dbReference type="InParanoid" id="B8MF46"/>
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    <dbReference type="PhylomeDB" id="B8MF46"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Low_temperature_requirement_A"/>
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        <property type="entry name" value="Ntr2"/>
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        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LOW TEMPERATURE REQUIREMENT A"/>
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    </dbReference>
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        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED16145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="958" mass="107034" checksum="4CCB45B1E97B9092" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MF48</accession>
    <name>B8MF48_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TBP-associated factor 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_012550</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483381.1">
        <property type="nucleotide sequence ID" value="XM_002483336.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B8MF48">
        <property type="interactions" value="628"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MF48"/>
    <dbReference type="GeneID" id="8104103"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_012550"/>
    <dbReference type="eggNOG" id="KOG1932">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002317_2_0_1"/>
    <dbReference type="InParanoid" id="B8MF48"/>
    <dbReference type="OMA" id="EQPDYQW"/>
    <dbReference type="OrthoDB" id="308861at2759"/>
    <dbReference type="PhylomeDB" id="B8MF48"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09839">
        <property type="entry name" value="M1_like_TAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000011">
        <property type="entry name" value="Transcription initiation factor TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057345">
        <property type="entry name" value="Ig-like_TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037813">
        <property type="entry name" value="TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057991">
        <property type="entry name" value="TPR_TAF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25316">
        <property type="entry name" value="TAF2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25577">
        <property type="entry name" value="TPR_TAF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 Ig-like" evidence="10">
        <location>
            <begin position="575"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 TPR repeats" evidence="11">
        <location>
            <begin position="759"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1183"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1229"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1262"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1274"/>
            <end position="1286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED16147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1286" mass="145457" checksum="BF289096E2116CBE" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8MF52</accession>
    <name>B8MF52_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Retinol dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_012590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483385.1">
        <property type="nucleotide sequence ID" value="XM_002483340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MF52"/>
    <dbReference type="STRING" id="441959.B8MF52"/>
    <dbReference type="GeneID" id="8104188"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_012590"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_0_1"/>
    <dbReference type="InParanoid" id="B8MF52"/>
    <dbReference type="OMA" id="YKITEMT"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="PhylomeDB" id="B8MF52"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43490">
        <property type="entry name" value="(+)-NEOMENTHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43490:SF99">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED16151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="216" mass="23055" checksum="C31634D926C86C24" modified="2009-03-03" version="1">MGEQNIVLITDVDQGIKAASSLSSLGSGNVSSLQLVVTSDESISSAKNTIEDKYGRLDVLVNNAGITLDVKEKGTPIRSLMQRTFEVNVFGAAAVTEAFIPLLEKSSNPRIVFTSSSVGSLTRASDLTNPWSKTPITTYRTSKPALNMLMLSYAALLHEKGFKVNASCPGYIGTNLNDHRGTGSIDDGAVSLARPVTLRKDGETGTFSTAEEVRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFI0</accession>
    <name>B8MFI0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_017880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483948.1">
        <property type="nucleotide sequence ID" value="XM_002483903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFI0"/>
    <dbReference type="STRING" id="441959.B8MFI0"/>
    <dbReference type="GeneID" id="8109045"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_017880"/>
    <dbReference type="HOGENOM" id="CLU_2110592_0_0_1"/>
    <dbReference type="InParanoid" id="B8MFI0"/>
    <dbReference type="OrthoDB" id="5426109at2759"/>
    <dbReference type="PhylomeDB" id="B8MFI0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED16714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="12761" checksum="C95425301BBB9F78" modified="2009-03-03" version="1">MTTRSNPLLVPKIIGLVLEKVELVSDLFSCACVNNTWNVAAPRELYKDSLNDMQFRTPDIGSLNCLLVASRRYLLLMKPRTQTLGLDALKSVARSVIANTQSSFCGWMEVVLQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFX8</accession>
    <name>B8MFX8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo-keto reductase (AKR13), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_009660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483079.1">
        <property type="nucleotide sequence ID" value="XM_002483034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFX8"/>
    <dbReference type="STRING" id="441959.B8MFX8"/>
    <dbReference type="GeneID" id="8102762"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_009660"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_1"/>
    <dbReference type="InParanoid" id="B8MFX8"/>
    <dbReference type="OMA" id="DDWRKTN"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="PhylomeDB" id="B8MFX8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED15845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="340" mass="37041" checksum="B99FECEA548D7994" modified="2009-03-03" version="1">MPSKLHPLGKNGPLVPALGFGLMGMSQPHYGVLPSDEGRFALLDRAVEIGATFWDTADQYGDNEELLGKWFKQTGKRQEIFLATKFGYVQHSKAYETDSSAAYCKESCAKSLERLGVDTIDLYYLHSANFETPIEETMRALVELQAEGKIKHIGLSMISSTTLRRACKVAPVAAVQTEYSVFSREIEGTAGTDLLAACRELGVAVVVATPLGRGLITDAFSKGEAIADGPDIRPVAIPRFMAENAPTNTATVNQFKAFADKKGCTVAQLALAWLLKRGEDIFPIPGTKKIKYLEENWAAQDVSLSDEEEAEIDSFLESATIVGGTVPPQFASYIFKDTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MG02</accession>
    <name>B8MG02_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tyrosinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_009870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483103.1">
        <property type="nucleotide sequence ID" value="XM_002483058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MG02"/>
    <dbReference type="STRING" id="441959.B8MG02"/>
    <dbReference type="GeneID" id="8102783"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_009870"/>
    <dbReference type="eggNOG" id="ENOG502RM4B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035914_0_0_1"/>
    <dbReference type="InParanoid" id="B8MG02"/>
    <dbReference type="OMA" id="GTHINQT"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="PhylomeDB" id="B8MG02"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF116">
        <property type="entry name" value="TYROSINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877482" evidence="2">
        <location>
            <begin position="22"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED15869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="408" mass="43719" checksum="8F4F10118721DD44" modified="2009-03-03" version="1">MRYTTLVGGALALLSSTPVLAQTASTTLPTAASTSTSQAASQLNTLSQYAKNVTTGNLDNGVTSKRGGCNLSNLKIRREWSTFSTAQKEAYINAVLCLQSKPSRTPSDLVSGARTRYDDFVATHINQTLNIHYTGTFLAWHRYFTWEFEQTLINECGYTGTVPYWNWPASANSLETYSVFDGSATSMSGNGAPRGPNDTDSDIELTLGNYPIVYLPLGTGGGCVTSGPFVNYTVNLGPVALSLPGGATGAAANPLGYNPRCLKRDLTTALIQRYANFTSVVSLILNNNDIADFQLAMQGVPGSGSIGVHGGGHYAMGGDPGRDVFVSPGDPAFWHHHGMIDRVWWIWQTLDLANRQDAISGTNTFLNNPPSANTTLDTVIDLGYAAGEMIAMRELMSTTGGPFCYIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8MG30</accession>
    <name>B8MG30_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA hydroxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_010150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483131.1">
        <property type="nucleotide sequence ID" value="XM_002483086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MG30"/>
    <dbReference type="STRING" id="441959.B8MG30"/>
    <dbReference type="GeneID" id="8102811"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_010150"/>
    <dbReference type="eggNOG" id="ENOG502SCSP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049925_0_0_1"/>
    <dbReference type="InParanoid" id="B8MG30"/>
    <dbReference type="OMA" id="ATPAHYD"/>
    <dbReference type="OrthoDB" id="2328924at2759"/>
    <dbReference type="PhylomeDB" id="B8MG30"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40128">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40128:SF1">
        <property type="entry name" value="PHYTANOYL-COA HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED15897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="36547" checksum="094142B0F07843BF" modified="2009-03-03" version="1">MPDVEIKIHSGLEVKDGPLLSENIAHLTPSSPSEPLETLRARYNQDGMLLLKGLLPREDVLRTRTKYFEMMSPSGILQPDTQPVQGIFNSARASDDFPGIGAGAAGKNGRPGGESAQVFIDLAIQAHYEDWYTKDLAKHPALLDFMAKFTGWNENTLGLNRSLLRNNVPGTKPIGVHYDQIFLRYGEPTSVTAWVPIGDISLTGGGLIYFENGDALGRQLEQDFTRKARDAGMTDEETKNAFNQNMMSTGLLSECPLEFARQYNWRWLVSDYEAGDVVLHKPHAIHASTINNDPNNVIRLATDLRFVDQSKPYDERWTNFYRFGDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGF2</accession>
    <name>B8MGF2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_013720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483506.1">
        <property type="nucleotide sequence ID" value="XM_002483461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGF2"/>
    <dbReference type="STRING" id="441959.B8MGF2"/>
    <dbReference type="GeneID" id="8099171"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_013720"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_6_1"/>
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    <dbReference type="OMA" id="LGSWRWY"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
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    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF160">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="77"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED16272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="553" mass="60230" checksum="BDEE8B8A1DB944BC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGP9</accession>
    <name>B8MGP9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HMG box protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_018670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="interactions" value="250"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MGP9"/>
    <dbReference type="GeneID" id="8100977"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_018670"/>
    <dbReference type="eggNOG" id="ENOG502SQXT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042807_1_0_1"/>
    <dbReference type="InParanoid" id="B8MGP9"/>
    <dbReference type="OMA" id="KRQHDPN"/>
    <dbReference type="OrthoDB" id="5550281at2759"/>
    <dbReference type="PhylomeDB" id="B8MGP9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF5">
        <property type="entry name" value="BOX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="117"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="117"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="192"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED16800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="306" mass="33255" checksum="B6C93EBE1F7E04C9" modified="2009-03-03" version="1">MSRKDESKAKDAFVTVNVDEFSRARDKFIIGLAGLQSAVSDLSRFYLDHTNTILNRGPVLAENSLTSGLAGGFASSLFENALLGSAVAQHALGQDAGKSETGEKKKRKRAPHDPNAPKRALTPYFLYMQHNRQLIANELGPDAKPKDVADEGTVRWSNMSDEEKAVWKKLYNDNLAVYRAKMNAYKAGLPIPEDDNVKADNQLQQSVAAAEAEAEEETDSPSESESEESDESDIPAKEPTPPPSKRRRGGALKTPASPVSTKKASPEKKKQSTPPKKDTSSRKSIGGSTDGKRKSKKRKSEVGGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGU4</accession>
    <name>B8MGU4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_014210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483559.1">
        <property type="nucleotide sequence ID" value="XM_002483514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGU4"/>
    <dbReference type="GeneID" id="8107804"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_014210"/>
    <dbReference type="HOGENOM" id="CLU_2361156_0_0_1"/>
    <dbReference type="InParanoid" id="B8MGU4"/>
    <dbReference type="OrthoDB" id="5243754at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED16325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="96" mass="10919" checksum="8DE8352D5E2F1217" modified="2009-03-03" version="1">MYLSYSRYLLVIRPRTAGPNRVQSGAVLKKLELHRTILRCGAVWSRFLGTDRLQIRGEHDREKAIRITNSTEGILIATSSYTKGDIVGMRESIKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGY5</accession>
    <name>B8MGY5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS maltose transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_014580</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483600.1">
        <property type="nucleotide sequence ID" value="XM_002483555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGY5"/>
    <dbReference type="GeneID" id="8107841"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_014580"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_11_3_1"/>
    <dbReference type="InParanoid" id="B8MGY5"/>
    <dbReference type="OMA" id="WIIEASW"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="PhylomeDB" id="B8MGY5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF57">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="457"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="65"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED16366.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="538" mass="59831" checksum="8636501FE5188655" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2024-01-24" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B8MH89</accession>
    <name>B8MH89_TALSN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">TSTA_021290</name>
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    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002484257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MH89"/>
    <dbReference type="STRING" id="441959.B8MH89"/>
    <dbReference type="GeneID" id="8109386"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_021290"/>
    <dbReference type="HOGENOM" id="CLU_1107729_0_0_1"/>
    <dbReference type="InParanoid" id="B8MH89"/>
    <dbReference type="PhylomeDB" id="B8MH89"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED17068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="251" mass="28595" checksum="24B4A3F5C72BC771" modified="2009-03-03" version="1">MVGNSRDHRHTGRRRYRIGPSVIVARTSTSHATDLRYPSSEIFCAPTQHQWGQIDGNTDMPDPDVMFTHLGQGEKRIQIALNESIKSIQPFTLKIKNVSWWYLHRPCQAFTNTFIANDRILTHTICLGRGLEWLRADAARKYFRPTTIPKEYKRASTHGRKLFEETSQFNLGLETQYGENIINKRPSIDMIPAGSRASDVLLYQAGSHIPNRPFQLSMNAQRCNLATIGYAYYDSGGRAYLTYRISPETGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIX3</accession>
    <name>B8MIX3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Septin AspB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_050730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
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    <dbReference type="eggNOG" id="KOG2655">
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    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="PhylomeDB" id="B8MIX3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:ascospore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="C:mating projection base"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cell division control 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="91"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="410"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="410"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED15635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="467" mass="52999" checksum="4E6CF9587FD72E69" modified="2009-03-03" version="1">MAAAAVNGSATAPGEKPTSPIPSASSKAASPYVERSNPMGGASTAQTVSSKDPKAVAQAATDMRNVVRRKLTGYVGFANLPNQWHRKSVRKGFNFNVMVVGESGLGKSTLINTLFNTSLYPPKERKGPSHDIIPKTVSIQGISADIEENGVRLRLTVVDTPGFGDFVNNDDSWRPIVENIEQRFDAYLEAENKVNRMNIVDNRVHACVYFIQPTGHSLKPLDIEVMRRLHTKVNLIPVIAKADTLTDEEIALFKQRILADIQYHSIQIFEGPRYELDDEETIAENQEIMSKVPFAVVGANAEVTTPDGRKVRGRRYPWGVIEVDNEEHCDFVKLRQMLIRTHMEELKEHTNNVLYENYRSDKLTQMGVAQDPSVFKEVNPAVKQEEERALHEQKLAKMEAEMKMVFEQKVREKESKLKQSEDELYARHREMKDQLERQRQDLEEKKARLESGRPLEKESKRKGFSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJ49</accession>
    <name>B8MJ49_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_051470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485664.1">
        <property type="nucleotide sequence ID" value="XM_002485619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJ49"/>
    <dbReference type="GeneID" id="8103369"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_051470"/>
    <dbReference type="HOGENOM" id="CLU_3207914_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJ49"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED15711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="45" mass="4976" checksum="5F0BB597F0C1C5AE" modified="2009-03-03" version="1">MLLTKCYAILNAIMHASFANNTLDHKLKLTDEKAGALKLNPSLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MK09</accession>
    <name>B8MK09_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleoporin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_043000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484779.1">
        <property type="nucleotide sequence ID" value="XM_002484734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MK09"/>
    <dbReference type="STRING" id="441959.B8MK09"/>
    <dbReference type="GeneID" id="8104944"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_043000"/>
    <dbReference type="eggNOG" id="KOG3091">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023804_0_1_1"/>
    <dbReference type="InParanoid" id="B8MK09"/>
    <dbReference type="OMA" id="MMQTRLH"/>
    <dbReference type="OrthoDB" id="6162375at2759"/>
    <dbReference type="PhylomeDB" id="B8MK09"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.490:FF:000005">
        <property type="entry name" value="Nucleoporin complex subunit 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.3600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024864">
        <property type="entry name" value="Nup54/Nup57/Nup44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025712">
        <property type="entry name" value="Nup54_alpha-helical_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000:SF0">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13874">
        <property type="entry name" value="Nup54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18570">
        <property type="entry name" value="Nup54_57_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="3" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup54 alpha-helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="426"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED14826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="466" mass="50445" checksum="E676982822D898E9" modified="2009-03-03" version="1">MSLFGAQPQQQQSGGLFGNTANKTPSLFGNTQQQPATGGSLFGNAQNKPATGTGLFGSTTTTTQQPASGGGLFGASTNQAQPQQQTSSLFGASQTQNKPAGGLFGGQQNTQAQTQPSGIFGSTTTTQQKPAGSLFGSTTQQTQQSGTGLFGATNNAQQQQSLFGGGSLFGNQQQQQQPQQQQQQQTPQLGQTLNQSQLGSSLWSPGRAITGVHRTVPAQMEILKDKWDPTNLTSPFRGYTYNHPGEDHAPFFQPTAEDDPTKWEEALKSRPGPGYVPLLLKGFMELGQRAVRQKDFLSALQTRLHQINNILTDLLSRHDLKISVRIADCRRKHLVLSQRCLSLAAKTQILRNRGYAMDDAEEELKKKLIQLERAIFDPSITGRAEEIWARMLAVREHSKRLAAEIEKTGSAGSNNEGEAALDENAMKTAKKILEDYASQIQHLQKELTAIGKELDEAQKLAGTNSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKR0</accession>
    <name>B8MKR0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial-processing peptidase subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alpha-MPP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Inactive zinc metalloprotease alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Matrix processing peptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_043790</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484862.1">
        <property type="nucleotide sequence ID" value="XM_002484817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKR0"/>
    <dbReference type="FunCoup" id="B8MKR0">
        <property type="interactions" value="1052"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MKR0"/>
    <dbReference type="GeneID" id="8097887"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_043790"/>
    <dbReference type="eggNOG" id="KOG2067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_5_2_1"/>
    <dbReference type="InParanoid" id="B8MKR0"/>
    <dbReference type="OMA" id="LKYHHSP"/>
    <dbReference type="OrthoDB" id="277191at2759"/>
    <dbReference type="PhylomeDB" id="B8MKR0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017087">
        <property type="term" value="C:mitochondrial processing peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000023">
        <property type="entry name" value="Mitochondrial processing peptidase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000032">
        <property type="entry name" value="Mitochondrial processing peptidase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="11">
        <location>
            <begin position="51"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="12">
        <location>
            <begin position="204"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="12">
        <location>
            <begin position="361"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00083075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED14909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="583" mass="63715" checksum="1851D3A2106CD4A4" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8ML22</accession>
    <name>B8ML22_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposable element tc3 transposase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_048780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485391.1">
        <property type="nucleotide sequence ID" value="XM_002485346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ML22"/>
    <dbReference type="STRING" id="441959.B8ML22"/>
    <dbReference type="GeneID" id="8107060"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_048780"/>
    <dbReference type="eggNOG" id="ENOG502SCE0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033666_0_0_1"/>
    <dbReference type="InParanoid" id="B8ML22"/>
    <dbReference type="OMA" id="CELHIEV"/>
    <dbReference type="OrthoDB" id="4737581at2759"/>
    <dbReference type="PhylomeDB" id="B8ML22"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052338">
        <property type="entry name" value="Transposase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022:SF119">
        <property type="entry name" value="TC1-LIKE TRANSPOSASE DDE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022">
        <property type="entry name" value="TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="2">
        <location>
            <begin position="215"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED15438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="339" mass="39916" checksum="4BAAF1E1724339FA" modified="2009-03-03" version="1">MPPPRRRTARRELDPCMRARICELHIEVHWGYKRIHRAHLEIPMTTIRNTIKKEQERINQRSKTRSGAPAKLTDEDKQKLIDLTIQNPHIKYEELRNAVDNKVTIRTIQNMFQQIHKRKWKQPLRYETYTPHEWQRILWSDECTVERGKGDQLIWTWHSLSEQLQEHDIREIRTGKSIKKMFWGAFKFDQRSPLVSLTSDGSSAGGGITVTVIRQLYMEQLPELLGDGDIFMQDNAPVHRAHIIRNLLQELGLNIMEWPPYSPDLYPIENIWAIMKTIIVNDHPELQNAPDNDQTLYSLIQAAKEAWESIEARVLRSLSNTMPNRVRAVIEADGWYTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8ML50</accession>
    <name>B8ML50_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_049060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485419.1">
        <property type="nucleotide sequence ID" value="XM_002485374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ML50"/>
    <dbReference type="STRING" id="441959.B8ML50"/>
    <dbReference type="GeneID" id="8100622"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_049060"/>
    <dbReference type="eggNOG" id="ENOG502SJ8Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1090623_0_0_1"/>
    <dbReference type="InParanoid" id="B8ML50"/>
    <dbReference type="OrthoDB" id="5392779at2759"/>
    <dbReference type="PhylomeDB" id="B8ML50"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED15466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="255" mass="29031" checksum="8478BCF18432686F" modified="2009-03-03" version="1">MRRAVTATQLMGLHERRHYRFKVLNDDNGLDPVNIWNCIVSMENIMFLVLGPPSSTGGTTSNPAMEKVAATSSTTAPSLRNQSSNILPTLIIHATSKILKRNQLYIPQQTFDMTREIDQELIKMTEQLPSSSWRPPSLAGLELDSVQAFWEARRAWDHMYYYTIVNQLHLPYTLCMRHTPRVIYSSMACVNASRKILIRQIAIHFVALIAGMTLILAHLVSHSHDENDKFNSDNVLVHQRSSDRVTLEQALECMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8ML88</accession>
    <name>B8ML88_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 14">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_044690</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 14"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484956.1">
        <property type="nucleotide sequence ID" value="XM_002484911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ML88"/>
    <dbReference type="FunCoup" id="B8ML88">
        <property type="interactions" value="532"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8ML88"/>
    <dbReference type="GeneID" id="8104145"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_044690"/>
    <dbReference type="eggNOG" id="KOG3187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034302_6_0_1"/>
    <dbReference type="InParanoid" id="B8ML88"/>
    <dbReference type="OMA" id="WSYILWQ"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="PhylomeDB" id="B8ML88"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED15003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="259" mass="29694" checksum="AC7AF6A2A4B02370" modified="2009-03-03" version="1">MPPKKSTAGKKPVSGLTRTYLFLYNLLNFTLWATCTVRTALRLFEKQQQNDLQNVSSIPTEIFPLLVVTQSLAALEILHSLLGIVRAPLITTAMQVASRFVVVWGIMYTFREGSELYDSVLSKYFSDIPFVQQAVSDGLMGVSGKLQYGDLAFFGCMFAWGITECIRYGFFVLQLGGLPVPGWWQWLRYNTFFVLYPIGIASECVFMYISLGHAERYVHKYYKWFLVIVMGIYVPGSYILYTHMMAQRRRVMRGKTRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLV8</accession>
    <name>B8MLV8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_101240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486122.1">
        <property type="nucleotide sequence ID" value="XM_002486077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLV8"/>
    <dbReference type="STRING" id="441959.B8MLV8"/>
    <dbReference type="GeneID" id="8101812"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_101240"/>
    <dbReference type="eggNOG" id="ENOG502STYZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_970117_0_0_1"/>
    <dbReference type="InParanoid" id="B8MLV8"/>
    <dbReference type="OMA" id="DIFPELW"/>
    <dbReference type="OrthoDB" id="2744543at2759"/>
    <dbReference type="PhylomeDB" id="B8MLV8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="164"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="255" mass="29244" checksum="E8810F80FA37407F" modified="2009-03-03" version="1">MPLRPYKPTDSLSLATIKAQCDLTDPLALYCRNLDANQVQLSQSGGDDDKQWKAHIKSLQRSFELEILFPGSVCWVILQHSDQHDEDGSEKIVGFAIWNRHGHSSAAQKWKANGQRFSNRLKGILSYTTMTLSYPFDRSINHTNMTKFHHRIHSCPSPLPANHKLPRERWELEALYIAPSHQRQGYGIEALSWGINVAKEERVEIWVWSSDSGRRLYEKGGFEVLGRIGFGDLLDNSITQDSEVGVWVMVWRDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MM42</accession>
    <name>B8MM42_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP-binding cassette transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_098100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485792.1">
        <property type="nucleotide sequence ID" value="XM_002485747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MM42"/>
    <dbReference type="STRING" id="441959.B8MM42"/>
    <dbReference type="GeneID" id="8108449"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_098100"/>
    <dbReference type="eggNOG" id="KOG0061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1240848_0_0_1"/>
    <dbReference type="InParanoid" id="B8MM42"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="PhylomeDB" id="B8MM42"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF91">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED13554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="223" mass="24914" checksum="D671192E32985E5C" modified="2009-03-03" version="1">MTFVQFMRRATDNVTGSIDRGTLAGVMGGSGAGKSTFVNVLMGKTSNIGGVVAVNNSPSKVGRYKKVIGHVPEETFSPRIDPLREHYFHGIEKMLILKPTPSLSLTAWNYRMCEIHKSEVLRRQSQWWTTKSVSIGMELAAVHMAIFLDEPTSGLDATSASSMIRTLKVLARLGIAVIFIIHQPWSEVFDLFDSLFLVEMDRLFTKVLKPRPNSILRMWVSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMC0</accession>
    <name>B8MMC0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="15">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TSTA_099260</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="15"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485912.1">
        <property type="nucleotide sequence ID" value="XM_002485867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMC0"/>
    <dbReference type="STRING" id="441959.B8MMC0"/>
    <dbReference type="GeneID" id="8104004"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_099260"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020639_1_1_1"/>
    <dbReference type="InParanoid" id="B8MMC0"/>
    <dbReference type="OMA" id="IEMNMVF"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="PhylomeDB" id="B8MMC0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF104">
        <property type="entry name" value="CYTOCHROME B2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5 17" id="KW-0349">Heme</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="19">
        <location>
            <begin position="7"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="20">
        <location>
            <begin position="113"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="76"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EED13674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="489" mass="53589" checksum="02CC4B9C18C10BCB" modified="2009-03-03" version="1">MSQQNKGVQISGAEVAQHNNKDSCWIAVRGKVYDVTDFLEEHPGGARLLLKCAGRDATEDYDAIHPAQLIEESLPDSAFKGTVDPSELDRPKLADKSVRNAQKEGKKDPDSPPPLSAMLNVRDFEKVAERHLAENSWAYYTAGADDEYSKAEAELAYRKVLFRPRILRNVGRVDTRTQILGQDVSLPIYISAVGIAKFAHPQGECTLAAAAGREGIAQLVATRSSMSIESIMKARTGGPQQPIFFQLYMHKDAKISDATILKAVKAGVKGIWLTVDSPVTGKRERDERLKANVDVGEQNDKIGGKGKPVQGVAKTLSSTVSPYLDWDTISYIRKLTNLPLVIKGIQSVEDAILAHKHKVNGIVISNHGGRSQDTAQAPLLTLLEINKYAPQIITDKKMQIFIDGGVRRGTDVVKALALGATAVGMGRPFLYSMSSGYGEAGTRRMIEIMREEIEQNMALVGATKISELRRELLNTSRLERDLTTFIAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNX5</accession>
    <name>B8MNX5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_104330</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486452.1">
        <property type="nucleotide sequence ID" value="XM_002486407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNX5"/>
    <dbReference type="STRING" id="441959.B8MNX5"/>
    <dbReference type="GeneID" id="8103204"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_104330"/>
    <dbReference type="eggNOG" id="KOG1369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014393_4_0_1"/>
    <dbReference type="InParanoid" id="B8MNX5"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="PhylomeDB" id="B8MNX5"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24000">
        <property type="entry name" value="ASKHA_NBD_HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF29">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="7">
        <location>
            <begin position="54"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="8">
        <location>
            <begin position="314"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED14214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="642" mass="71038" checksum="739E498D23A96041" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8MP22</accession>
    <name>B8MP22_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_104750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486499.1">
        <property type="nucleotide sequence ID" value="XM_002486454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MP22"/>
    <dbReference type="GeneID" id="8098696"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_104750"/>
    <dbReference type="eggNOG" id="ENOG502RZM0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009027_0_0_1"/>
    <dbReference type="InParanoid" id="B8MP22"/>
    <dbReference type="OMA" id="IAQWINY"/>
    <dbReference type="OrthoDB" id="5381672at2759"/>
    <dbReference type="PhylomeDB" id="B8MP22"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="513"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="628" mass="68803" checksum="E6EC190D9E9C3398" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8MP82</accession>
    <name>B8MP82_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-hydroxyacyl-CoA dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_105330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486559.1">
        <property type="nucleotide sequence ID" value="XM_002486514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MP82"/>
    <dbReference type="STRING" id="441959.B8MP82"/>
    <dbReference type="GeneID" id="8098754"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_105330"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_13_1_1"/>
    <dbReference type="InParanoid" id="B8MP82"/>
    <dbReference type="OMA" id="NCICPWM"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="PhylomeDB" id="B8MP82"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF86">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00290)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED14321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="307" mass="33676" checksum="3E9F2F6D881205B5" modified="2009-03-03" version="1">MSQFHPTISRESLQDKVIVLTGGAHGIGKSLVELCTQHGAYVCFGDIDEKAGRGVEESANASQKSSPPTARFVPVDVTNYQSVLSLFKTALSLYGRIDHVVANAGIVERGNWFDPALTVESVEEQPTTKVLDVNLLGCLYTARIASVYLRQNRREGQDRSLTLVSSVAGFKESPGLFVYQASKHGVLGLMRSLRKYITFPTTHNIRVNAICPWMTETAMVAGIEDGWRKAQLPINQPLDVAKVITGVLAAEGQEERVSGMAMYVEGGRAWEIERNLDRLQPQWLGEEPSESLEKGQAVLGDGMNWAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPI2</accession>
    <name>B8MPI2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_106300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486659.1">
        <property type="nucleotide sequence ID" value="XM_002486614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPI2"/>
    <dbReference type="GeneID" id="8098783"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_106300"/>
    <dbReference type="eggNOG" id="ENOG502SQ0U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_44_8_1"/>
    <dbReference type="InParanoid" id="B8MPI2"/>
    <dbReference type="OMA" id="CAGMDMF"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="PhylomeDB" id="B8MPI2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF7">
        <property type="entry name" value="DJ-1_PFPI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="67"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="217" mass="24113" checksum="E2D0B11C89264BED" modified="2009-03-03" version="1">MAPVRFGIPLYEYQALDVMGPLDVIAGYEENNLIPKGLHENGLELEFYHISDTTHKSKPTNLELENLDVVATVTTAECPPIDYLLFGGPLPSYKLSEEMNTFIQDRVAKGEIKTIFTTCTGAAVLAQTGLLDGKRATVHMGIIDLARQMYPAVNWVQKTDKGNWVIDGNIWTANGACTGMDMFAHWLIQQCGLELAKYQFWTLNYAPRGIDGQLLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPL0</accession>
    <name>B8MPL0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xenobiotic compound monooxygenase, DszA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_106590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486687.1">
        <property type="nucleotide sequence ID" value="XM_002486642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPL0"/>
    <dbReference type="STRING" id="441959.B8MPL0"/>
    <dbReference type="GeneID" id="8103559"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_106590"/>
    <dbReference type="eggNOG" id="ENOG502QSR6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022256_0_0_1"/>
    <dbReference type="InParanoid" id="B8MPL0"/>
    <dbReference type="OMA" id="QVEGYHL"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="PhylomeDB" id="B8MPL0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF30">
        <property type="entry name" value="XENOBIOTIC COMPOUND MONOOXYGENASE, DSZA FAMILY (AFU_ORTHOLOGUE AFUA_6G01920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="2">
        <location>
            <begin position="34"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED14449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="490" mass="54084" checksum="6AB5F5BBF61178BB" modified="2009-03-03" version="1">MAESSSSNGAPKKHILLNAFDMSTVGHLSPGQWKNPTDKSATKRSLDYWVNLAKLLERGDINALFLADTYGGYDTYEGSLDNCIRRAAQWPMTDPAIPITAMAAVTKNLTFAITASTSFEPPFLLAKRFSTLDHLTGGRFGWNIVTGWKKGAFKAIGLDEPIDHDRRYAQADEYLRVLYKLWEGSWADDAIVKDVENDVYADPDKIRTIKHDGEFYHLESRHIVDPSPQRTPLLFQAGTSPAGSQFGATHAEAIFVSAHSPSVLKPRVANIRKLAQEAGRDPQSIKFFSTVTPIIGRTEEEAKAKFEEAKKYASTIGGLVLFSGWTGIDISKVPLDEEIDPAKHSLEKHKVHSISETLTARTPELPSITPRIIAEAASLGGLGPVPVGTPSQVADILEKWVQEADIDGFNVGYVITPGTFEDVVDLLIPELRKRGLYPEKRDDVSGLTAREKIYGQGQSKLRDDHVGSKYKYNVYKEDAPFEKEVDEGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPM7</accession>
    <name>B8MPM7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GABA permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_106760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486704.1">
        <property type="nucleotide sequence ID" value="XM_002486659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPM7"/>
    <dbReference type="STRING" id="441959.B8MPM7"/>
    <dbReference type="GeneID" id="8103576"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_106760"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_1_0_1"/>
    <dbReference type="InParanoid" id="B8MPM7"/>
    <dbReference type="OMA" id="CICATAC"/>
    <dbReference type="OrthoDB" id="4351681at2759"/>
    <dbReference type="PhylomeDB" id="B8MPM7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF1">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED14466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="23878" checksum="19FC491810119386" modified="2009-03-03" version="1">MRNDRDIAWDIDEAIEMRGGSRAKSVAERDNADLNRLGKKQVIKRNFGFMSMLGFSCTVMITWEGELLLFDDNFANGGYAGSVYGYIIVWIGTLCVFATMGELASMAPTSGGQYHWVSMLSPPKVQKLLSYVIGWLMVVGWQAAAASEGYLVGSLIQGMIIMNNGEYSPQPYQGTLLLWASIFFAVFINSVLSSALPKIEGLLLILHVLGFFAILIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQB7</accession>
    <name>B8MQB7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Norsolorinic acid reductase, putative</fullName>
            <ecNumber evidence="5">1.1.1.91</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_058080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.91" evidence="5"/>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487430.1">
        <property type="nucleotide sequence ID" value="XM_002487385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQB7"/>
    <dbReference type="STRING" id="441959.B8MQB7"/>
    <dbReference type="GeneID" id="8108944"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_058080"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_2_1"/>
    <dbReference type="InParanoid" id="B8MQB7"/>
    <dbReference type="OMA" id="DEGMAIH"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="PhylomeDB" id="B8MQB7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047681">
        <property type="term" value="F:aryl-alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF7">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="40"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED13319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="375" mass="41837" checksum="D6C14DCBC5A5BE6B" modified="2009-03-03" version="1">MAMIPPSPPKSALGRHRLLSPNASVRVSPLCLGGMSKPFGFGTNWGMGLGECTKEMAYELLDTFYYLDGNFVDTANTYQGSQSEEWIGDWMKDRGRHNEMIIATKYAMTPMAGKSVNQSNYGGTGNKCMHISIEASLKAMNTDYIDIYYVHAWDYASSILELMQSLNALVIHGKVLYLGISDAPAWFVTKANAYARHHGLRTFSVYQGRYSAQQRDMEREIIPMAREEGMAILAFGVLVNGYFKTLGSEGAGARRIPPTILIGREQQVSQVLDNVAKRHNVPLTSVTLAYAMQKTPYFYPIIGGRKVEHLKANIEALKLRLTPEDVAEIETGYNFDIGFTHNFINTAHHMIEGPQHVTILHDLGYFDYVAPPCCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQP6</accession>
    <name>B8MQP6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Flavin-binding monooxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_059560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487580.1">
        <property type="nucleotide sequence ID" value="XM_002487535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQP6"/>
    <dbReference type="STRING" id="441959.B8MQP6"/>
    <dbReference type="GeneID" id="8107425"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_059560"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019225_1_0_1"/>
    <dbReference type="InParanoid" id="B8MQP6"/>
    <dbReference type="OMA" id="WISPFWI"/>
    <dbReference type="OrthoDB" id="2915840at2759"/>
    <dbReference type="PhylomeDB" id="B8MQP6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED13469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="607" mass="68912" checksum="CFFD94E4C98BBD2C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>B8MS66</accession>
    <name>B8MS66_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Polyketide synthase, putative</fullName>
            <ecNumber evidence="12">2.3.1.94</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_001920</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.94" evidence="12"/>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487778.1">
        <property type="nucleotide sequence ID" value="XM_002487733.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MS66"/>
    <dbReference type="GeneID" id="8098686"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_001920"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_6_2_1"/>
    <dbReference type="InParanoid" id="B8MS66"/>
    <dbReference type="OMA" id="CHPASAY"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="PhylomeDB" id="B8MS66"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047879">
        <property type="term" value="F:erythronolide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041068">
        <property type="entry name" value="HTH_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050444">
        <property type="entry name" value="Polyketide_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681:SF6">
        <property type="entry name" value="POLYKETIDE SYNTHASE 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681">
        <property type="entry name" value="POLYKETIDE SYNTHASE 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18558">
        <property type="entry name" value="HTH_51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01294">
        <property type="entry name" value="PKS_PP_betabranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="382"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="1285"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="1662"/>
            <end position="1739"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1285"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1447"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1745"/>
            <end position="1771"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="1320"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="1504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED12124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="2606" mass="290141" checksum="F8AAE1D1A92D34DE" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSU1</accession>
    <name>B8MSU1_TALSN</name>
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        <submittedName>
            <fullName evidence="2">Terpene synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_000610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the terpene synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED11984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002487593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSU1"/>
    <dbReference type="STRING" id="441959.B8MSU1"/>
    <dbReference type="GeneID" id="8108684"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_000610"/>
    <dbReference type="eggNOG" id="ENOG502QQN6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005861_0_0_1"/>
    <dbReference type="InParanoid" id="B8MSU1"/>
    <dbReference type="OMA" id="PFTWTAC"/>
    <dbReference type="OrthoDB" id="2343925at2759"/>
    <dbReference type="PhylomeDB" id="B8MSU1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016102">
        <property type="term" value="P:diterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050148">
        <property type="entry name" value="Terpene_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31739:SF25">
        <property type="entry name" value="(E,E)-GERANYLLINALOOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31739">
        <property type="entry name" value="ENT-COPALYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="988" mass="111309" checksum="1D468F754E7D91D5" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8MT51</accession>
    <name>B8MT51_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_003160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487908.1">
        <property type="nucleotide sequence ID" value="XM_002487863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MT51"/>
    <dbReference type="GeneID" id="8098012"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_003160"/>
    <dbReference type="HOGENOM" id="CLU_1176085_0_0_1"/>
    <dbReference type="InParanoid" id="B8MT51"/>
    <dbReference type="OMA" id="MEINLNV"/>
    <dbReference type="OrthoDB" id="3945463at2759"/>
    <dbReference type="PhylomeDB" id="B8MT51"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="236" mass="27478" checksum="F27B4DCA9C16C680" modified="2009-03-03" version="1">MEINLNVAKYSISFCFTGHSPFQSTKGSVRAIRRTLKAIRQEKSDLSEATQLALKALQKYAVQNEILEHQQQGLVDALIGEKKQQKRGRPLDLIDKDNSGEAQFFSPGRIEAARQRIQNIESQKEQGKIEAANRRTQKAFARQQKAQEIQERRETRIREREEKRRQKELEKERLRVAREAQNEVKRGKERLAKQVNTKKRRYSKVIESNEEVSSKRPKTGISRSGRAINLPIRFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8MT67</accession>
    <name>B8MT67_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_002300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487818.1">
        <property type="nucleotide sequence ID" value="XM_002487773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MT67"/>
    <dbReference type="STRING" id="441959.B8MT67"/>
    <dbReference type="GeneID" id="8102841"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_002300"/>
    <dbReference type="eggNOG" id="ENOG502S1ZY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_934161_0_0_1"/>
    <dbReference type="InParanoid" id="B8MT67"/>
    <dbReference type="OMA" id="NEPRDQE"/>
    <dbReference type="OrthoDB" id="3068835at2759"/>
    <dbReference type="PhylomeDB" id="B8MT67"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053221">
        <property type="entry name" value="Burnettramic_acid_biosynth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38887">
        <property type="entry name" value="CHROMOSOME 21, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38887:SF1">
        <property type="entry name" value="RAS MODIFICATION PROTEIN ERF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="351" mass="38511" checksum="A26EEABEF6BA0A2F" modified="2009-03-03" version="1">MSNHTSLSDDIDNTEDQPPAYTTSHPLPILATEKSLAYGSTSAHTQESSSRSTQPQPIKKPIAIPAVDSSFDAPFIRTYAPVLKDYKLPQEVFLSFLDRLNKAISSSPPLQALDVTGGILNSVPILFPLHWIGSAVSGLAKLGNTGVSKSRTDSLLKDANRDIFGPRGLKSEVARLDALAHIAKIPILDSRGKVSRQAPLSQQLSAVEQRPGSFGGAKKDGELNTAIDAQQRRIQILQPWIADLEFDILPWTSQSKLTRFNETLKKYNNTDNREPRGRRRRAQDSNPDFKNGDEAQDNEEGGDPFRKSLWLIIHSSHLIMSMDVLKTSLLTSSNRPQVSTAIGPATNFAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTD5</accession>
    <name>B8MTD5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_002460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487834.1">
        <property type="nucleotide sequence ID" value="XM_002487789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTD5"/>
    <dbReference type="STRING" id="441959.B8MTD5"/>
    <dbReference type="GeneID" id="8102857"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_002460"/>
    <dbReference type="eggNOG" id="ENOG502SC13">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060131_6_5_1"/>
    <dbReference type="InParanoid" id="B8MTD5"/>
    <dbReference type="OMA" id="HYSMILR"/>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="PhylomeDB" id="B8MTD5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="215" mass="23717" checksum="9CAC69738D02723A" modified="2009-03-03" version="1">MAIHLRPASEADLSIIVDVSTAAFPPSVDAIARHLFPGDLHYSEDVRQARIARKSVKFQMNSTRIMVAVDDASDGKIVGYSIWEVPVAGGDDKNDDDGEIILPPLAQEGSDRAPFMELRRILEDDVREQFGDEGTKGVWTLDSLGVHPNHQKRGIGRMLLDWGVEEAAKHGKGCYLVATPAGLPLYRAAGFEDVKVLDIFGTPHVSMRRRIFKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUA8</accession>
    <name>B8MUA8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine-threonine protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_108020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488368.1">
        <property type="nucleotide sequence ID" value="XM_002488323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUA8"/>
    <dbReference type="STRING" id="441959.B8MUA8"/>
    <dbReference type="GeneID" id="8106866"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_108020"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043429_1_0_1"/>
    <dbReference type="InParanoid" id="B8MUA8"/>
    <dbReference type="OMA" id="AKKTHMD"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="B8MUA8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="146"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED11612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="480" mass="54262" checksum="DF237F0E641372F2" modified="2009-03-03" version="1">MTAKLSLEFKSYQEDEDFLSQQQPEPNRRSQTLIFHHNGNKWWIKVTVKGTFTSARNTKEPPVSTKRKRRQEFQDFVRLINFESVSLLKDTVTEIIIGEGLEATVAIELNHNADTPSNTVAKYARNLQCEIREDPSRVNYPPCQDFPSFRRINATELSDREEIVDGVFRVTHDRTPLILKVVDRPFYQPRDTEVLRQELENLKEFQGVSNIAQAVGIAVDTNPYSTSTTLDSQQVVVGVLLELYSGGSLQQVFDENCLENYSWQKWPLQIARALHCFHRAGKTHLDVKPSNVVLDASGNAILIDISGVGGITRAWCAPEIRNTLSPFELSFNIRQWSDVWAYGRLLLEITKHAEKSPYVKHLESIADELMKEDIHRPIESAGPTAMVYNTLMNFSRILPINIILVESPIGSATYMKLDTHIITRHIGDLAPGPSRLRFGFLSHPAIPQWGEPLVEASSPVPGSQAVFRSLAGPHEDLRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUV6</accession>
    <name>B8MUV6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_110540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488630.1">
        <property type="nucleotide sequence ID" value="XM_002488585.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MUV6"/>
    <dbReference type="GeneID" id="8107286"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_110540"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002055_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUV6"/>
    <dbReference type="OMA" id="GEEWYRC"/>
    <dbReference type="OrthoDB" id="3787051at2759"/>
    <dbReference type="PhylomeDB" id="B8MUV6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="1006"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="389"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="656"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1278"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="659"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="676"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1278"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1298"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1350"/>
            <end position="1363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED11874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1911" mass="216868" checksum="FBE33691710535D1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MV20</accession>
    <name>B8MV20_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_110890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488666.1">
        <property type="nucleotide sequence ID" value="XM_002488621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MV20"/>
    <dbReference type="STRING" id="441959.B8MV20"/>
    <dbReference type="GeneID" id="8110118"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_110890"/>
    <dbReference type="eggNOG" id="ENOG502QW3K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015282_0_0_1"/>
    <dbReference type="InParanoid" id="B8MV20"/>
    <dbReference type="OMA" id="HGDVTKH"/>
    <dbReference type="OrthoDB" id="4222077at2759"/>
    <dbReference type="PhylomeDB" id="B8MV20"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED11910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="374" mass="42649" checksum="2EF8466738FA7ED5" modified="2009-03-03" version="1">MGVLTSFRQVARPYSLRYGAAKALDNSGSVSDALRNLIMHHADTRTFLKYYLSRRIDKDVAGIIRGLDPQEEMMRAACRMSRTIDPNRPQELTTAQSSSVNQLPEIQDLIRRRDHLGRRLGRPLSQHKGTVKYDLYQQLTKELGSARRRARDALLKEIQNQYDQEQPMLEVQRQLSGVKLSESVSHRLYQSEEIPLPQKRLSAALLTLPRPTLEGEMLRRTEAIDAIAAYCLFEEGDTCRIAHDKRQYSVHGPIDVTHKLSHPEVETKDQGISPQESKLHEAIRAVSMDSRSRNRKEKVQRPLLCFLCVGNPNLDIVKRTQTFKAHGDVTKHIKRKHLKHIVEGNVVSCGVCGQTFLRKMELQRHASDAHSTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MV58</accession>
    <name>B8MV58_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_008120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962662">
        <property type="protein sequence ID" value="EED11514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488695.1">
        <property type="nucleotide sequence ID" value="XM_002488650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MV58"/>
    <dbReference type="GeneID" id="8110149"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_008120"/>
    <dbReference type="eggNOG" id="ENOG502S2ZX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_4_0_1"/>
    <dbReference type="InParanoid" id="B8MV58"/>
    <dbReference type="OMA" id="DTWTNYG"/>
    <dbReference type="OrthoDB" id="2740399at2759"/>
    <dbReference type="PhylomeDB" id="B8MV58"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="60"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED11514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="550" mass="62995" checksum="03AF34FB750D1590" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MV70</accession>
    <name>B8MV70_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_008220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962662">
        <property type="protein sequence ID" value="EED11526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488707.1">
        <property type="nucleotide sequence ID" value="XM_002488662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MV70"/>
    <dbReference type="GeneID" id="8110140"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_008220"/>
    <dbReference type="HOGENOM" id="CLU_1471677_0_0_1"/>
    <dbReference type="InParanoid" id="B8MV70"/>
    <dbReference type="OrthoDB" id="5147528at2759"/>
    <dbReference type="PhylomeDB" id="B8MV70"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="64"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED11526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="184" mass="20528" checksum="F51829186C68B3CA" modified="2009-03-03" version="1" fragment="single">VMLASLEAAKDKLSIYYKDTDNIDGYLYAIGTILSPQDKLHLESSLEKYSENLAQEQQILGAPPTNTVSNAQPRTWWKYYQDEFPGMARLARDVLSIPASGAGAAKEERTQQQITVDPISDDEEDEGLSIEPRATLHGPSTKALGKRRLRDIAEDAESNQEDDSKVTSLLEIQHQVLGRVRKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTA8</accession>
    <name>B8LTA8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_059800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002339869.1">
        <property type="nucleotide sequence ID" value="XM_002339828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTA8"/>
    <dbReference type="STRING" id="441959.B8LTA8"/>
    <dbReference type="GeneID" id="8102369"/>
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    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1476084_0_0_1"/>
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    <dbReference type="OrthoDB" id="5549573at2759"/>
    <dbReference type="PhylomeDB" id="B8LTA8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="183" mass="20304" checksum="3B304741DFE42335" modified="2009-03-03" version="1">MYRSVALLNTLSKFLKAIIICRISYAMESKGLLPSSHLGGYKGISTDHAIQIILNQICGAWGRGHAVIFMLLLDISGTYNNAHHLQLLHNMKKRCLGHFVPTKIRIPEEISSQIPIPTGILQGSPISPILYLIYNADLIEDCADIVNHTTISGWMDDVALITIDNIETETIRKLQKASKIADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8LU11</accession>
    <name>B8LU11_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nulp1-pending protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_072340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341228.1">
        <property type="nucleotide sequence ID" value="XM_002341187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LU11"/>
    <dbReference type="FunCoup" id="B8LU11">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LU11"/>
    <dbReference type="GeneID" id="8102340"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_072340"/>
    <dbReference type="eggNOG" id="KOG2422">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008321_1_1_1"/>
    <dbReference type="InParanoid" id="B8LU11"/>
    <dbReference type="OMA" id="IWGKMPP"/>
    <dbReference type="OrthoDB" id="205993at2759"/>
    <dbReference type="PhylomeDB" id="B8LU11"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684">
        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04910">
        <property type="entry name" value="Tcf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="748" mass="84715" checksum="820AE9D5B2237777" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUK1</accession>
    <name>B8LUK1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP dependent RNA helicase (Dob1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_071700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341161.1">
        <property type="nucleotide sequence ID" value="XM_002341120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUK1"/>
    <dbReference type="FunCoup" id="B8LUK1">
        <property type="interactions" value="1164"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LUK1"/>
    <dbReference type="GeneID" id="8100169"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_071700"/>
    <dbReference type="eggNOG" id="KOG0948">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002902_0_1_1"/>
    <dbReference type="InParanoid" id="B8LUK1"/>
    <dbReference type="OMA" id="IMLKNYN"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="PhylomeDB" id="B8LUK1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13154">
        <property type="entry name" value="KOW_Mtr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000003">
        <property type="entry name" value="ATP dependent RNA helicase (Dob1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.300:FF:000001">
        <property type="entry name" value="Mtr4 exosome RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="166"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="444"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="372"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="738"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED23774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1078" mass="122211" checksum="04464D41FAB3DB30" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUM5</accession>
    <name>B8LUM5_TALSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_072720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341269.1">
        <property type="nucleotide sequence ID" value="XM_002341228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUM5"/>
    <dbReference type="STRING" id="441959.B8LUM5"/>
    <dbReference type="GeneID" id="8100188"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_072720"/>
    <dbReference type="eggNOG" id="ENOG502RQP3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1058077_0_0_1"/>
    <dbReference type="InParanoid" id="B8LUM5"/>
    <dbReference type="OrthoDB" id="4227354at2759"/>
    <dbReference type="PhylomeDB" id="B8LUM5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="259" mass="28256" checksum="49189B343B5B221E" modified="2009-03-03" version="1">MPVPDKKPSFFDKPNLFAHIYTTYASRVIQEYVASDRKDKINRTKIEKDIIRLTNEDPNLPILHKVSCTSMVLHTNTFEPFWADQRLAYSLPAKSLRRLTPQYNLIDELPCPSDDDTLSTLENFTDKKGKPRHKSAADTTARRGRGRPKAAPAKMNGKGKAGTGKAGTVAMKAPKSQAARPSQSGADNNKSKANGNNPNAPTTPVQAQPLRTASGKLISTKTARESFLECMAQGSSMKICGPSSDEESTTTDDDSDSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8LW11</accession>
    <name>B8LW11_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_077400</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA1 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341764.1">
        <property type="nucleotide sequence ID" value="XM_002341723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LW11"/>
    <dbReference type="STRING" id="441959.B8LW11"/>
    <dbReference type="GeneID" id="8102006"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_077400"/>
    <dbReference type="eggNOG" id="ENOG502S786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132216_1_0_1"/>
    <dbReference type="InParanoid" id="B8LW11"/>
    <dbReference type="OMA" id="EVSNPWK"/>
    <dbReference type="OrthoDB" id="1920692at2759"/>
    <dbReference type="PhylomeDB" id="B8LW11"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017384">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17098:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17098">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE MWFE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15879">
        <property type="entry name" value="MWFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED24377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="86" mass="9973" checksum="E32BBD2B8CBC2959" modified="2009-03-03" version="1">MGVPFEALIPYGIIIGMYCVTGVGLSLTKYYANDHKKARWNRDVWDKQMMERDFRITGTLRGQSTNPEAPTGFEVSNPWKLEKRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWU8</accession>
    <name>B8LWU8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MYB DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_079360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341968.1">
        <property type="nucleotide sequence ID" value="XM_002341927.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LWU8"/>
    <dbReference type="GeneID" id="8107625"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_079360"/>
    <dbReference type="eggNOG" id="KOG1878">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001697_0_0_1"/>
    <dbReference type="InParanoid" id="B8LWU8"/>
    <dbReference type="OMA" id="QQCIIHY"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="PhylomeDB" id="B8LWU8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051571">
        <property type="entry name" value="N-CoR_corepressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992">
        <property type="entry name" value="NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992:SF39">
        <property type="entry name" value="SMRTER, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SANT" evidence="3">
        <location>
            <begin position="992"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="4">
        <location>
            <begin position="997"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="997"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="879"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="934"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1404"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1508"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1595"/>
            <end position="1618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1650"/>
            <end position="2025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
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        <location>
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        </location>
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        </location>
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        <location>
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        </location>
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        <location>
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        </location>
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        <location>
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        </location>
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        <location>
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    </feature>
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        <location>
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        <location>
            <begin position="1946"/>
            <end position="1970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED24581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="2025" mass="223171" checksum="83FA750BC309FC54" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWY8</accession>
    <name>B8LWY8_TALSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">TSTA_079760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED24621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002341967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWY8"/>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_079760"/>
    <dbReference type="eggNOG" id="ENOG502SKPP">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1122407_0_0_1"/>
    <dbReference type="InParanoid" id="B8LWY8"/>
    <dbReference type="OrthoDB" id="3590765at2759"/>
    <dbReference type="PhylomeDB" id="B8LWY8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED24621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="297" mass="33325" checksum="BECEBFBFDF4C3D6A" modified="2009-03-03" version="1">MGTATYLSPVSHRRHSETGLATQSSPDSSIASQITSWKLRPGVHTPRAFITELAIIFESILVQLGPDDPSTPSSPEILMDDLRSSLSHEGRESTLPLPDWNEPNLSEMTKQAKRFAQVLAQVLYQYAAEFQHSVPGDPQLVVYSPCEGHKWVPAAGRLLRSNRSSPIPMMPYNGWLHQITCLRDALLAFENFEDVQLDFSDTIQRGTCPMESIREAFLFKIQTYKVNHSDIIYVAKALADPGLPSGGYSSQYRYGVVLPAALFAPSSSRLLRYIPTQLDINGEECVMFDFRTKYRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8LX73</accession>
    <name>B8LX73_TALSN</name>
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        <submittedName>
            <fullName evidence="5">Endothiapepsin, putative</fullName>
        </submittedName>
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        <name evidence="5" type="ORF">TSTA_062110</name>
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    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <dbReference type="NCBI Taxonomy" id="441959"/>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the peptidase A1 family.</text>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LX73"/>
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    <dbReference type="GeneID" id="8105590"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_062110"/>
    <dbReference type="HOGENOM" id="CLU_013253_0_3_1"/>
    <dbReference type="InParanoid" id="B8LX73"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="PhylomeDB" id="B8LX73"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002874560" evidence="3">
        <location>
            <begin position="21"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="48"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED22723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="327" mass="36505" checksum="156385405E581415" modified="2009-03-03" version="1">MATMLSYCLLCTLFSIVARGAKYDRSTAVGNQSDFSSVVPLTISNWGLTGQIEIGTPAQHLDVRFDLETSAVILNSTGHYNSSASTSFTNMDQSLWMELDDGSQSELWLGNETFDIGGTNFGNVPFWQLGEFSPPRYGDSLAFNGSAGVFGLDFGSWQGLEYPSFMWTVKKYLPGEWVYTIDLYRTWNNGTCRFGSIDSSEHHGTIGWANIGWATELFQAVNLTIISAGNRTSPENVWLAFLSNDLSLVWPRDVLDWYFNGTGATWSSNDQTYRYPCNITLPDVTFGFGNGTFRIPGSYLPYQRDANSKAFDRPGNNVVLPFFYYYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXB6</accession>
    <name>B8LXB6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_066440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340584.1">
        <property type="nucleotide sequence ID" value="XM_002340543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXB6"/>
    <dbReference type="STRING" id="441959.B8LXB6"/>
    <dbReference type="GeneID" id="8101247"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_066440"/>
    <dbReference type="eggNOG" id="KOG0742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004471_6_3_1"/>
    <dbReference type="InParanoid" id="B8LXB6"/>
    <dbReference type="OMA" id="HVISICA"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="PhylomeDB" id="B8LXB6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="607"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED23197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="819" mass="92670" checksum="FBDF94FAD2C2CEBD" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXK9</accession>
    <name>B8LXK9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_078650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341897.1">
        <property type="nucleotide sequence ID" value="XM_002341856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXK9"/>
    <dbReference type="FunCoup" id="B8LXK9">
        <property type="interactions" value="391"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LXK9"/>
    <dbReference type="GeneID" id="8101184"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_078650"/>
    <dbReference type="eggNOG" id="KOG1455">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026209_5_1_1"/>
    <dbReference type="InParanoid" id="B8LXK9"/>
    <dbReference type="OMA" id="SYEGWSH"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="PhylomeDB" id="B8LXK9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="54"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED24510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="347" mass="38389" checksum="11BCF86A2DF4BB47" modified="2009-03-03" version="1">MLAFSGIENTPINNTDTDRAATVDMGGITEEEGSLVLPDGTSLYTKSWKPEGIPRAIIAFYHGFSDHCNSFFDFFPNLASSGIEVRSLDQRGWGRSVISIPKLRGHYGSTSTVMADLHFFLQSLIPFTKEGTIPLFLMGHSMGGMNVLYYVLNPESPYHHQAENTNATTKVKLAGVMSVAPLVAVHPTTQPLKIVEYAGRIAKRIVPKMTMVQNIDAKWVSKNQAVVDDIKDDKGVLYHNTGTLEGLAGMLDRGAWLNDLHKKTTAANHADGKNVPPLWIGHGTEDRVTWCDATRRLAQSLDHVDDKTYKEYEGAYHKLMNEPDGVAESMTKDVTEWIEARLPKSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXN5</accession>
    <name>B8LXN5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histidine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Histidyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSTA_078910</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the aminoacylation of histidyl-tRNA in both the cytoplasm and the mitochondrion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="3"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341923.1">
        <property type="nucleotide sequence ID" value="XM_002341882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXN5"/>
    <dbReference type="FunCoup" id="B8LXN5">
        <property type="interactions" value="876"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LXN5"/>
    <dbReference type="GeneID" id="8110173"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_078910"/>
    <dbReference type="eggNOG" id="KOG1936">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025113_4_2_1"/>
    <dbReference type="InParanoid" id="B8LXN5"/>
    <dbReference type="OMA" id="CGGGNFK"/>
    <dbReference type="OrthoDB" id="1906957at2759"/>
    <dbReference type="PhylomeDB" id="B8LXN5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000015">
        <property type="entry name" value="Histidyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000021">
        <property type="entry name" value="Probable histidine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="81"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="370"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EED24536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="605" mass="66645" checksum="ECA1462A21663888" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2024-01-24" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXW3</accession>
    <name>B8LXW3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_062650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340165.1">
        <property type="nucleotide sequence ID" value="XM_002340124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXW3"/>
    <dbReference type="GeneID" id="8101061"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_062650"/>
    <dbReference type="HOGENOM" id="CLU_1939533_0_0_1"/>
    <dbReference type="InParanoid" id="B8LXW3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14648" checksum="585580E1ABEE71D5" modified="2009-03-03" version="1">MHLIWEEQSWLIDAVCNGRLNAVRSFLDSGVNLNSYNVCGFRLLNLTMTMLRLPRGPVKTTPWSRAIHVAVEVGADVVLPVLEADRPLDIAVRDDAEDTALHVAMHPLWLKFRRRQIVRMLLAAGAPVRV</sequence>
</entry>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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        </lineage>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:exocytosis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF4">
        <property type="entry name" value="GDP_GTP EXCHANGE FACTOR SEC2 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="RABIN3-RELATED"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="4">
        <location>
            <begin position="186"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="144"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="42"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="210"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED22812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="286" mass="31590" checksum="50786FD0688F197A" modified="2009-03-03" version="1">MQTATSVYTVTAGVKTTLFGEDYAPMKDSLSVSGTTCPHCGNDLVSQDAIAAQQRIQELEAQLKIYSEKASETAVRIADYENEIHNLRQQAQTWNNNNNHYNEATSTTAAATEQTHPPKTPDANSQQQQQQGRFANFASYFPYRRTGSRAGSKDSSTPPQTSHSNYTNSSPGGGGHTSPTNNTSFLSHDSSSDTNALALQTALSREQGLRKAAETQLSQAHSELEELTAQLFSQANEMVAQERKARAKLEERVALLEKRDGEKRKRLDRLEKAIVRVERVRELINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYC2</accession>
    <name>B8LYC2_TALSN</name>
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        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
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        <name evidence="3" type="ORF">TSTA_063320</name>
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    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED22851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002340197.1"/>
    </dbReference>
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    <dbReference type="STRING" id="441959.B8LYC2"/>
    <dbReference type="GeneID" id="8106619"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_063320"/>
    <dbReference type="eggNOG" id="KOG1968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003721_0_0_1"/>
    <dbReference type="InParanoid" id="B8LYC2"/>
    <dbReference type="OMA" id="RNHLVQQ"/>
    <dbReference type="OrthoDB" id="9996895at2759"/>
    <dbReference type="PhylomeDB" id="B8LYC2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF21">
        <property type="entry name" value="ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="526"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="63"/>
        </location>
    </feature>
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        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
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        <location>
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            <end position="206"/>
        </location>
    </feature>
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        <location>
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            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <end position="1116"/>
        </location>
    </feature>
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        <location>
            <begin position="1117"/>
            <end position="1126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED22851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1126" mass="125526" checksum="287701FC82410FAD" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZK7</accession>
    <name>B8LZK7_TALSN</name>
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        <submittedName>
            <fullName evidence="8">Fatty acid oxygenase PpoC, putative</fullName>
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        </submittedName>
    </protein>
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    </gene>
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        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.44" evidence="8"/>
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        <property type="protein sequence ID" value="EED22430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479393.1">
        <property type="nucleotide sequence ID" value="XM_002479348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZK7"/>
    <dbReference type="STRING" id="441959.B8LZK7"/>
    <dbReference type="GeneID" id="8103522"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_096790"/>
    <dbReference type="eggNOG" id="KOG2408">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002329_1_0_1"/>
    <dbReference type="InParanoid" id="B8LZK7"/>
    <dbReference type="OMA" id="RHYTIDY"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="PhylomeDB" id="B8LZK7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20612">
        <property type="entry name" value="CYP_LDS-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09817">
        <property type="entry name" value="linoleate_diol_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.640.10:FF:000005">
        <property type="entry name" value="Fatty acid oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034812">
        <property type="entry name" value="Ppo-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF13">
        <property type="entry name" value="LINOLEATE 10R-LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED22430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1125" mass="127191" checksum="360EF644530BD0F1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZR0</accession>
    <name>B8LZR0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_080750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477805.1">
        <property type="nucleotide sequence ID" value="XM_002477760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZR0"/>
    <dbReference type="STRING" id="441959.B8LZR0"/>
    <dbReference type="GeneID" id="8101380"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_080750"/>
    <dbReference type="HOGENOM" id="CLU_2623682_0_0_1"/>
    <dbReference type="InParanoid" id="B8LZR0"/>
    <dbReference type="PhylomeDB" id="B8LZR0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED20842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="78" mass="9069" checksum="3795AFCB88F12017" modified="2009-03-03" version="1">MALNPNPNGFEPEGKNHTQLDTYVNGKLTEYREGNDTILWAMFIQDFSKWTLDNLKKLIMLLKSHSVYVDEMNEHLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZR3</accession>
    <name>B8LZR3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_080780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477808.1">
        <property type="nucleotide sequence ID" value="XM_002477763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZR3"/>
    <dbReference type="STRING" id="441959.B8LZR3"/>
    <dbReference type="GeneID" id="8101383"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_080780"/>
    <dbReference type="eggNOG" id="ENOG502SX1Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114636_0_0_1"/>
    <dbReference type="InParanoid" id="B8LZR3"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="PhylomeDB" id="B8LZR3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED20845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="222" mass="26059" checksum="516B3EB1EFE29E0D" modified="2009-03-03" version="1">MDKSVNPYQWGFAIYRTVYTPQSDELWSSVLEKLESYMELSCKDPGYRDELSNIVVWDREKFNNASIDEIRKDFRREMLIPEMGDDEIKSDDDAATEDRKQDLYCQKQAELAEELGDEALWGEVNGSYCLLIDDEVFQSILNAPEPAKGMKMKWGTYEYIGFVKVVTVYERSFRNEHWPGWGKIDFRLLWWLRGEDEIEREAPVPLPEREGVYELPVITGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8M016</accession>
    <name>B8M016_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_081810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477911.1">
        <property type="nucleotide sequence ID" value="XM_002477866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M016"/>
    <dbReference type="STRING" id="441959.B8M016"/>
    <dbReference type="GeneID" id="8104819"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_081810"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_340149_0_0_1"/>
    <dbReference type="InParanoid" id="B8M016"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF22">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G11480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="650"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="680"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="710"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="749"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="777"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="510"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="522"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED20948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="835" mass="95521" checksum="F2108CDFF6485D45" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0E2</accession>
    <name>B8M0E2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aryl-alcohol dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_084700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478202.1">
        <property type="nucleotide sequence ID" value="XM_002478157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0E2"/>
    <dbReference type="STRING" id="441959.B8M0E2"/>
    <dbReference type="GeneID" id="8106076"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_084700"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036199_0_0_1"/>
    <dbReference type="InParanoid" id="B8M0E2"/>
    <dbReference type="OMA" id="YCVFHPM"/>
    <dbReference type="OrthoDB" id="686384at2759"/>
    <dbReference type="PhylomeDB" id="B8M0E2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19101">
        <property type="entry name" value="AKR_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43147:SF2">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43147">
        <property type="entry name" value="PROTEIN TAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="244"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED21239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="558" mass="62518" checksum="632B979122BD85EF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0Q9</accession>
    <name>B8M0Q9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase/esterase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_086750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478405.1">
        <property type="nucleotide sequence ID" value="XM_002478360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0Q9"/>
    <dbReference type="STRING" id="441959.B8M0Q9"/>
    <dbReference type="GeneID" id="8110081"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_086750"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_6_3_1"/>
    <dbReference type="InParanoid" id="B8M0Q9"/>
    <dbReference type="OMA" id="YIFPEFA"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="PhylomeDB" id="B8M0Q9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="100"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED21442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="371" mass="40549" checksum="EE4E41A14418D11F" modified="2009-03-03" version="1">MDFSNYGEPASEWTSYLYAHPIINQPWTKPSEEESLTEMHITGTNARAAHDQVKLKAHGLEGKFSCQDYEVGTRDGSSIPLRLYTPIGTPSPPGGRPIYVYFHGGGFLHGSIDTERSACALIATKLNIMVVHPCPRHVHEEKHPIPHHDAWDAMKWIIDHASSYGGDVGSLVIGGISSGANLAAYVVQQFSTANTTIYNENNAVRIKGQVLIVPWLIQPNAFPYGQFIEKDKTSLVQCSNALGLSTERLEWLSSILGVEDIANPIPNPALVDEKVLGSLPKTAIIIAGGDPLRDDGLIYASRLGKAGVRTKIHVFPGLPHHFAVYELPHPHVAYELRSASVCQNRVLESIQWALKDGGDQAGNAWVIEKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1B2</accession>
    <name>B8M1B2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA synthetase, putative</fullName>
            <ecNumber evidence="6">6.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_090470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="6"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478771.1">
        <property type="nucleotide sequence ID" value="XM_002478726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1B2"/>
    <dbReference type="STRING" id="441959.B8M1B2"/>
    <dbReference type="GeneID" id="8108135"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_090470"/>
    <dbReference type="eggNOG" id="KOG1175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_5_1"/>
    <dbReference type="InParanoid" id="B8M1B2"/>
    <dbReference type="OMA" id="FIMGRTD"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="PhylomeDB" id="B8M1B2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050218">
        <property type="term" value="F:propionate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43347">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43347:SF3">
        <property type="entry name" value="ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="5">
        <location>
            <begin position="7"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="79"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="558"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED21808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="709" mass="77691" checksum="60A06C455E0ECFAA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1G8</accession>
    <name>B8M1G8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyridine nucleotide-disulfide oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_091040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478827.1">
        <property type="nucleotide sequence ID" value="XM_002478782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1G8"/>
    <dbReference type="STRING" id="441959.B8M1G8"/>
    <dbReference type="GeneID" id="8101594"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_091040"/>
    <dbReference type="eggNOG" id="KOG1336">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003291_1_2_1"/>
    <dbReference type="InParanoid" id="B8M1G8"/>
    <dbReference type="OMA" id="YSPCAIP"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="PhylomeDB" id="B8M1G8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050260">
        <property type="entry name" value="FAD-bd_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43429:SF1">
        <property type="entry name" value="NAD(P)H SULFUR OXIDOREDUCTASE (COA-DEPENDENT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43429">
        <property type="entry name" value="PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="7">
        <location>
            <begin position="472"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED21864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="565" mass="61517" checksum="0EFC0D32E68CCC68" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8M282</accession>
    <name>B8M282_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin cytoskeleton-regulatory complex protein END3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Actin cytoskeleton-regulatory complex protein end3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Cytoskeletal adapter protein sagA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Endocytosis protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">TSTA_087820</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the END3 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478509.1">
        <property type="nucleotide sequence ID" value="XM_002478464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M282"/>
    <dbReference type="FunCoup" id="B8M282">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M282"/>
    <dbReference type="GeneID" id="8100911"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_087820"/>
    <dbReference type="eggNOG" id="KOG0998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040829_0_0_1"/>
    <dbReference type="InParanoid" id="B8M282"/>
    <dbReference type="OMA" id="DWLIPES"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="PhylomeDB" id="B8M282"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000323">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein end3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000339">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein END3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025604">
        <property type="entry name" value="End3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF174">
        <property type="entry name" value="GH06923P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12761">
        <property type="entry name" value="End3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="14" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15 22" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="13" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EH" evidence="24">
        <location>
            <begin position="9"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="25">
        <location>
            <begin position="41"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="24">
        <location>
            <begin position="138"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="22">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00025194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00029684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EED21546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="406" mass="46614" checksum="B60D6DA4E6E055CF" modified="2009-03-03" version="1">MAKRIEQWEVERYWEIFSSLSNGQPRLNNSQAASVLRNSRLRDEQLEKVWDLADVDGDGELDFEEFCVAMRLIFDLVNGEYQEVPRALPDWLIPESKAHLVQASAALTGSQEQFERIEDEDDTPGLKDGFDWYMSPSDKAKYEEIYSANKNHRGEITFDSLQPLYDSLDVPDTDIRSAWNLVNPAASSSINKDATLAFLHILNFRHEGFRIPRTVPPSLRASFESNKIDYQVDHVRPAQKWGADGDTETTTGRKAKFGDTYLSRLGVKSSYRPQGTDFSNTIQDEEWEKVRLRRELAELEAKLEAANRASEERRSGGSSSSARNDGRPNWAIIKKEALQLLEYKERELREMREGTGRTKDGEDLVRLREDIKTVADQVDGLKDHLDRRNEVLADLRRQIEDEKASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2W2</accession>
    <name>B8M2W2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_094630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479180.1">
        <property type="nucleotide sequence ID" value="XM_002479135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2W2"/>
    <dbReference type="STRING" id="441959.B8M2W2"/>
    <dbReference type="GeneID" id="8103793"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_094630"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2307942_0_0_1"/>
    <dbReference type="InParanoid" id="B8M2W2"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="PhylomeDB" id="B8M2W2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED22217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="100" mass="10706" checksum="F653C4979F9B4676" modified="2009-03-03" version="1">MAGALISGPLNDTFGRKTVLWIASFLVLAGGVVQVADTHYEGVIVLDRFGLDLVSGISLLLLSSISQSMGEVAPVEIQSPALYMYQFLQSFSQLVASWVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3B6</accession>
    <name>B8M3B6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Beta-galactosidase</fullName>
            <ecNumber evidence="4 13">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSTA_095370</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="4 13"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479251.1">
        <property type="nucleotide sequence ID" value="XM_002479206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3B6"/>
    <dbReference type="STRING" id="441959.B8M3B6"/>
    <dbReference type="GeneID" id="8103864"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_095370"/>
    <dbReference type="eggNOG" id="KOG0496">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005732_2_0_1"/>
    <dbReference type="InParanoid" id="B8M3B6"/>
    <dbReference type="OMA" id="NEYSGAC"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="PhylomeDB" id="B8M3B6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.20.10:FF:000001">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000065">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000088">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.390.10:FF:000001">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000040">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 13 17" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877261" description="Beta-galactosidase" evidence="15">
        <location>
            <begin position="22"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase" evidence="16">
        <location>
            <begin position="397"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EED22288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1011" mass="109983" checksum="1494FFD16029299F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3L5</accession>
    <name>B8M3L5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_096360</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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        <source>
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        <source>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="6GAL-like"/>
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        <property type="entry name" value="GH"/>
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        <property type="entry name" value="GH30_C"/>
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    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydr_30_2"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002874805" evidence="4">
        <location>
            <begin position="22"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Endo-beta-1,6-galactanase-like" evidence="5">
        <location>
            <begin position="101"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="6">
        <location>
            <begin position="368"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED19614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="457" mass="48698" checksum="371A03B7E99E4BC2" modified="2009-03-03" version="1">MRTSTSLIPLVISLSLDSALGQVKINTATKYQIIDGFGFSEAFGFGVGVQDAPTTQQNEALTYLFDKTKGAGFTILRNRVAADPGNTIEPNSPGSASGAPTYRWNGDDQSQVFWSKKARQMGVEYIYADAWSAPGFMKTNNNYENGGYLCGVTGETCSSGDWRQAYANYLVKYLQDYESEGITVDFIGFLNEPEFAASYDAMLSDGTKAASFIPILHSTIQKAGLSTGIICCDAEGWNDQVTYTAQLIEAGAEEYLSRISSHWYTSKGTSPINTTLRVWETEYADLDDGFSTTWHASGAFNEGLTWAGYIYQGLVDCNLSAFLYWIGAQSNSNAAGLVTLQGSGSSTTVTPSAALWAFAMFSRYIRPNAVRVGTSGAPSNTKAAAFVNTDGTTAVVMLNQGSTAQSVTLGGVTIASAVAYVMDSSVSSPTTLSTSISNGSVEATLPGYSLVTFVMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8M539</accession>
    <name>B8M539_TALSN</name>
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            <fullName evidence="1">Ser/Thr protein phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_029220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480079.1">
        <property type="nucleotide sequence ID" value="XM_002480034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M539"/>
    <dbReference type="GeneID" id="8099041"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_029220"/>
    <dbReference type="eggNOG" id="ENOG502RZN8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060372_0_1_1"/>
    <dbReference type="InParanoid" id="B8M539"/>
    <dbReference type="OMA" id="WAFGHIY"/>
    <dbReference type="OrthoDB" id="550558at2759"/>
    <dbReference type="PhylomeDB" id="B8M539"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844">
        <property type="entry name" value="SER/THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844:SF2">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED19645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="203" mass="23599" checksum="B4E6326126478EA8" modified="2009-03-03" version="1">MDDLSRSDQSLVRRFNFLDHTRYDIFSTATILGCTLFSHISKEQEEHIDFYLNNFYYIQDWSLDAHQQTHAADVAWLNREIDTLAHSEPYRTVVVLTHHCPTIHLQASNPKHKDGNISPAFVADLSGESCWKRENVKLWAFGHIYVNCDFDKAGKRVVIDQRGFYSALAEGFEFVCKEMLKIFSANFDSLGLRRSIYQLQTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5D3</accession>
    <name>B8M5D3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ferric-chelate reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_030080</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480173.1">
        <property type="nucleotide sequence ID" value="XM_002480128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5D3"/>
    <dbReference type="FunCoup" id="B8M5D3">
        <property type="interactions" value="385"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M5D3"/>
    <dbReference type="GeneID" id="8106575"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_030080"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010365_3_2_1"/>
    <dbReference type="InParanoid" id="B8M5D3"/>
    <dbReference type="OMA" id="YMYLYMP"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="PhylomeDB" id="B8M5D3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF27">
        <property type="entry name" value="FAD-BINDING FR-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="10">
        <location>
            <begin position="222"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric reductase NAD binding" evidence="11">
        <location>
            <begin position="500"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED19739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="791" mass="89534" checksum="10E64071A961EDFB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5R1</accession>
    <name>B8M5R1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome P450, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_032910</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480472.1">
        <property type="nucleotide sequence ID" value="XM_002480427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5R1"/>
    <dbReference type="STRING" id="441959.B8M5R1"/>
    <dbReference type="GeneID" id="8105030"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_032910"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_605452_0_0_1"/>
    <dbReference type="InParanoid" id="B8M5R1"/>
    <dbReference type="OMA" id="ITWRGSA"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="PhylomeDB" id="B8M5R1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF5">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED20038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="501" mass="57392" checksum="99F7A1D170DBA550" modified="2009-03-03" version="1">MRNHSFDAMAIIDLENLTPWLFWLAVTGLVLSELYFALQSSRISKFTGSTESKLRSVIKDFNNGRFYKPWGTPPIIIDGGKKRLLELSDTPVLSQRAVYADMFGFKHTMNKFNHTEVNIIKSRLFGRVLNVNGPNQVARLYPVLQKRLSSFLKDELEVLDTPDSRTTVIPLASTAKVLSSRLMAVTFFGENLGSNPDLAEALLRHPSQTIACMGAFQFTPSFLMSLVHNIMTRGGREMRKIQSYLMPIIDQGVDSWDEAKGIKESTVFYDLIEQSHPNRDYWTPFTLSQSILGLWLAASHQPWVNLYHILYELCIRPEWQQIIREEVMQHGALNDFTKLNQLSLLDGFMRETARLNSLDKIAIRRKALEDYTFSDGYTKVPAGAVVCVDSYAASHNPRIYPRPETFDAGRFTNGQSHDQTNRFTDVSENYLIWGFGSLACPGRHHASLVLKLVVATLLVDYELELDAKRSRRHWMWESFSIPYNSTRLVLRRRSEPTSHWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6L0</accession>
    <name>B8M6L0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S15, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_027660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479906.1">
        <property type="nucleotide sequence ID" value="XM_002479861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6L0"/>
    <dbReference type="FunCoup" id="B8M6L0">
        <property type="interactions" value="220"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M6L0"/>
    <dbReference type="GeneID" id="8109685"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_027660"/>
    <dbReference type="eggNOG" id="KOG2815">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078264_0_0_1"/>
    <dbReference type="InParanoid" id="B8M6L0"/>
    <dbReference type="OMA" id="HLQEHRN"/>
    <dbReference type="OrthoDB" id="441444at2759"/>
    <dbReference type="PhylomeDB" id="B8M6L0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_uS15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_uS15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15, BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321:SF26">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="197"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED19472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="303" mass="34196" checksum="8791CB895A24290C" modified="2009-03-03" version="1">MPPRLSIQGLSKPFSGSSHISNPLTIVKREPCKIDIRAGSFETRQRRRHDPFLMAQSRQRRAANISRQQALDNERQAALGDPVKSEPTPFIQQIEAIQSGKDVTGTTSNVSTWNHFIKADEFELALEYSKALTEPLPPQDANIADPEAYKQSVQQHEIAHHNAREAMHRIVQLSSGNTADRTRVNIEACIETFGRHNTDKILPPKPTAVTTTQHPEKTPRAGPDTGSPEVQVAILTTKIMNLSRHLQSTNKDRHNKRNLRVLVHKRQKLLQYLRRKERGGPRWQNLMTSLGLSDAAWKGEISM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7G4</accession>
    <name>B8M7G4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_036100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480818.1">
        <property type="nucleotide sequence ID" value="XM_002480773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7G4"/>
    <dbReference type="GeneID" id="8101881"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_036100"/>
    <dbReference type="eggNOG" id="ENOG502S2KS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086074_0_0_1"/>
    <dbReference type="InParanoid" id="B8M7G4"/>
    <dbReference type="OMA" id="CNMWRTV"/>
    <dbReference type="OrthoDB" id="61370at2759"/>
    <dbReference type="PhylomeDB" id="B8M7G4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="222" mass="24829" checksum="3534A6D091901EFA" modified="2009-03-03" version="1">MAPQEWDPLLPNASRQTGRNYTGILTKTIVYGITLVLFLIAYAFTISSILLPSWVSYNSEKPPLHYSYGLHRRCSSLTDICEPFPQYEDCHGENRYFCSMWRSVGFLMTFAVVLMSLAIVAYIIILSGGKRLRETGWGVLSTIIILSVAVQVASMALIAYLFDNDERFFVGWQLDKSFAFCTVSWCISLFCAAAVVVAARTLPPEGGYELIPGYGNDTEEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7G5</accession>
    <name>B8M7G5_TALSN</name>
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            <fullName evidence="2">Hypothetical pathogenicity factor</fullName>
        </submittedName>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480819.1">
        <property type="nucleotide sequence ID" value="XM_002480774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7G5"/>
    <dbReference type="STRING" id="441959.B8M7G5"/>
    <dbReference type="GeneID" id="8101882"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_036110"/>
    <dbReference type="eggNOG" id="ENOG502SMWI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_415662_0_0_1"/>
    <dbReference type="InParanoid" id="B8M7G5"/>
    <dbReference type="OrthoDB" id="4161595at2759"/>
    <dbReference type="PhylomeDB" id="B8M7G5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="553" mass="63509" checksum="D343F38320D925DC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7V7</accession>
    <name>B8M7V7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">TSTA_031010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480270.1">
        <property type="nucleotide sequence ID" value="XM_002480225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7V7"/>
    <dbReference type="STRING" id="441959.B8M7V7"/>
    <dbReference type="GeneID" id="8101778"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_031010"/>
    <dbReference type="eggNOG" id="ENOG502QVC1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022342_0_0_1"/>
    <dbReference type="InParanoid" id="B8M7V7"/>
    <dbReference type="OrthoDB" id="4416636at2759"/>
    <dbReference type="PhylomeDB" id="B8M7V7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF10">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="239"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="607"/>
            <end position="637"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED19836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="739" mass="82994" checksum="318FB30C87ECE85C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B8M974</accession>
    <name>B8M974_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_112050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002481316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M974"/>
    <dbReference type="STRING" id="441959.B8M974"/>
    <dbReference type="GeneID" id="8098860"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_112050"/>
    <dbReference type="HOGENOM" id="CLU_1295165_0_0_1"/>
    <dbReference type="InParanoid" id="B8M974"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="PhylomeDB" id="B8M974"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="164"/>
        </location>
    </feature>
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        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="213" mass="24175" checksum="0E39C0CFF4B961A8" modified="2009-03-03" version="1">MVHTTQSVPSRIFKAVRRAVKADMFTHLHQMTGLLSFSHSDSGIQSEAFCCGVYCQRVGGSDVDSSQINSISNYSYAKIIISQSPSEVPMQSWYPKNGMSFRQPLDRNIHISDEADFDDVSENENLMADTPSDNSEHDDNTRDMNEDDLLDIDNDEDDVKDEDDGVVDPYYWGYGVSQILVANDTHREQSRCIVRSKLLLDHSVHTKHIRKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9G5</accession>
    <name>B8M9G5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_115240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="441959.B8M9G5"/>
    <dbReference type="GeneID" id="8101334"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_115240"/>
    <dbReference type="eggNOG" id="KOG2651">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016581_1_0_1"/>
    <dbReference type="InParanoid" id="B8M9G5"/>
    <dbReference type="OMA" id="LQAPYNW"/>
    <dbReference type="OrthoDB" id="10258156at2759"/>
    <dbReference type="PhylomeDB" id="B8M9G5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052220">
        <property type="entry name" value="METTL25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496">
        <property type="entry name" value="CGI-41 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496:SF0">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="152"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="625" mass="70927" checksum="14320B1E6B06F6AB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9L7</accession>
    <name>B8M9L7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_117910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482011.1">
        <property type="nucleotide sequence ID" value="XM_002481966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9L7"/>
    <dbReference type="STRING" id="441959.B8M9L7"/>
    <dbReference type="GeneID" id="8105849"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_117910"/>
    <dbReference type="eggNOG" id="ENOG502T1HR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_423875_0_0_1"/>
    <dbReference type="InParanoid" id="B8M9L7"/>
    <dbReference type="OrthoDB" id="4226885at2759"/>
    <dbReference type="PhylomeDB" id="B8M9L7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="672"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED18019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="745" mass="82078" checksum="D2853AC2A04BACD5" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9V4</accession>
    <name>B8M9V4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_118720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482098.1">
        <property type="nucleotide sequence ID" value="XM_002482053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9V4"/>
    <dbReference type="STRING" id="441959.B8M9V4"/>
    <dbReference type="GeneID" id="8099796"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_118720"/>
    <dbReference type="eggNOG" id="KOG0835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022000_5_0_1"/>
    <dbReference type="InParanoid" id="B8M9V4"/>
    <dbReference type="OMA" id="WEDVWSV"/>
    <dbReference type="OrthoDB" id="10264655at2759"/>
    <dbReference type="PhylomeDB" id="B8M9V4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000086">
        <property type="entry name" value="Cyclin domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000126">
        <property type="entry name" value="Cyclin domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED18106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="297" mass="32465" checksum="E44441486C00A88B" modified="2009-03-03" version="1">MTSALTLDSLSNALATPAQLSSSSSSLDGIPSDLESSIRFAGALLTQAAGVLLRLPQDVIAQAIVIFTRFWIGPDGGSFAIHSAKDVSAASIYLIAKLSFHPTSPRSVLNTYNYLLSKQASPLWFINPSGVVGKPKPETYYLSEGGYQSQRMVLLKTETIILRTLGFNTHIVIPHTIALTYLQTINAASSALGKRVFEHLNASLLSPQLLYVTHQPNALAVAAIYLAAREVGVKLAEDEWWEVFDVDREELGFLVVAMNSMEEFAKAEKETWKGKSIPVVVEDVEKELQQRQSQEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8MA00</accession>
    <name>B8MA00_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS alpha-glucoside transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_119160</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482144.1">
        <property type="nucleotide sequence ID" value="XM_002482099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MA00"/>
    <dbReference type="STRING" id="441959.B8MA00"/>
    <dbReference type="GeneID" id="8104366"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119160"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="InParanoid" id="B8MA00"/>
    <dbReference type="OMA" id="NHTMAYT"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="PhylomeDB" id="B8MA00"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF27">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="48"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED18152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="530" mass="57381" checksum="40756A5A258F688B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B8MA62</accession>
    <name>B8MA62_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Retrotransposon polyprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">TSTA_121340</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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        <source>
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    </evidence>
    <sequence length="1697" mass="196374" checksum="CAA64B930972B715" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <sequence length="314" mass="35350" checksum="55583F9616BC2B86" modified="2009-03-03" version="1">MEPNFFPKPTTPQSSKTELQIGGIKVYIFGLAQAKEQGHTDLGVLYIAHGRTRTYRDSEGLAHEILHQVRSDTKPKKAGLIVVAVDARNHGERKLNELTNMGWNEGNESHAQDMLSSISGGAHDYELLIDYLPTYLTEFNNFYNFMSGISLGGHTSWRIATSSVAQRGKLHGLAIIIGCPKLTSLLLARLGVDLEATASKFDVSEDLIHIIPYDKLSTILTEEQQRRWPRALANLVTEMDRVTEQAYPRNIPTYILNGRLDPLVPDKFTAQWVKQRKTEGYQNIEYLAQENTGHACTNQMVDNVSGWLVRMLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAD9</accession>
    <name>B8MAD9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylcholine-sterol O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_123700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482633.1">
        <property type="nucleotide sequence ID" value="XM_002482588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAD9"/>
    <dbReference type="FunCoup" id="B8MAD9">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="GeneID" id="8108281"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_123700"/>
    <dbReference type="eggNOG" id="ENOG502QVNJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007657_0_0_1"/>
    <dbReference type="InParanoid" id="B8MAD9"/>
    <dbReference type="OMA" id="WGYKPFL"/>
    <dbReference type="OrthoDB" id="10250441at2759"/>
    <dbReference type="PhylomeDB" id="B8MAD9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="857" mass="94177" checksum="5EAFEC9C2FEABB08" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAF8</accession>
    <name>B8MAF8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_123880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482652.1">
        <property type="nucleotide sequence ID" value="XM_002482607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAF8"/>
    <dbReference type="STRING" id="441959.B8MAF8"/>
    <dbReference type="GeneID" id="8098340"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_123880"/>
    <dbReference type="HOGENOM" id="CLU_1161814_0_0_1"/>
    <dbReference type="InParanoid" id="B8MAF8"/>
    <dbReference type="OrthoDB" id="1918at2759"/>
    <dbReference type="PhylomeDB" id="B8MAF8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="239" mass="25675" checksum="C717481E29779035" modified="2009-03-03" version="1">MVAVPSDLQVFVKWKEQTVFAGEDVECTITFKNVAEIAEEKSNNPSHQQQHQRRVSRPLTALNGTNNDGYFAAKSSPTFFFNGSRRSVTSSPRRPTLGNGRNPTRGIPKESALSPRLEAEKTGRTISTSPSNASHLRSPRTRTPSFPTDFKFPPSPDPAAETDGNTNGTPAGTNDGPASRQLSKQPPSLTQQAHLAPATRILSNSSVSGSLWGSKPILDLGVCSSKILETSQLSSYASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8MB42</accession>
    <name>B8MB42_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen debranching enzyme</fullName>
            <ecNumber evidence="5">2.4.1.25</ecNumber>
            <ecNumber evidence="6">3.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glycogen debrancher</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TSTA_124640</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of (1-&gt;6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin.</text>
            <dbReference type="EC" id="3.2.1.33"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the glycogen debranching enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="5"/>
    <dbReference type="EC" id="3.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482735.1">
        <property type="nucleotide sequence ID" value="XM_002482690.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B8MB42">
        <property type="interactions" value="431"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MB42"/>
    <dbReference type="GeneID" id="8098415"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_124640"/>
    <dbReference type="eggNOG" id="KOG3625">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001517_2_0_1"/>
    <dbReference type="InParanoid" id="B8MB42"/>
    <dbReference type="OMA" id="YEEGHVH"/>
    <dbReference type="OrthoDB" id="10248904at2759"/>
    <dbReference type="PhylomeDB" id="B8MB42"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004135">
        <property type="term" value="F:amylo-alpha-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11327">
        <property type="entry name" value="AmyAc_Glg_debranch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000039">
        <property type="entry name" value="Glycogen debranching enzyme Gdb1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000242">
        <property type="entry name" value="Glycogen debranching enzyme Gdb1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000333">
        <property type="entry name" value="Glycogen debranching enzyme Gdb1, putative (AFU_orthologue AFUA_1G02140)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010401">
        <property type="entry name" value="AGL/Gdb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032788">
        <property type="entry name" value="AGL_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029436">
        <property type="entry name" value="AGL_euk_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032792">
        <property type="entry name" value="AGL_glucanoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006421">
        <property type="entry name" value="Glycogen_debranch_met"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01531">
        <property type="entry name" value="glyc_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569:SF2">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14701">
        <property type="entry name" value="hDGE_amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14702">
        <property type="entry name" value="hGDE_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14699">
        <property type="entry name" value="hGDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="14 21" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Eukaryotic glycogen debranching enzyme N-terminal" evidence="18">
        <location>
            <begin position="37"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme glucanotransferase" evidence="19">
        <location>
            <begin position="136"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme central" evidence="20">
        <location>
            <begin position="722"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme C-terminal" evidence="17">
        <location>
            <begin position="1056"/>
            <end position="1511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF14701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF14702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EED18743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1524" mass="171759" checksum="083C77CEFA730118" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBJ0</accession>
    <name>B8MBJ0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hexose carrier protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_116440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481846.1">
        <property type="nucleotide sequence ID" value="XM_002481801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBJ0"/>
    <dbReference type="GeneID" id="8102036"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_116440"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="InParanoid" id="B8MBJ0"/>
    <dbReference type="OMA" id="QWQSTWA"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="PhylomeDB" id="B8MBJ0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF31">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877407" evidence="8">
        <location>
            <begin position="38"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="26"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED17854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="517" mass="56328" checksum="246AA057462C7616" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBQ8</accession>
    <name>B8MBQ8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Low-temperature viability protein ltv1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_119530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTV1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482183.1">
        <property type="nucleotide sequence ID" value="XM_002482138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBQ8"/>
    <dbReference type="FunCoup" id="B8MBQ8">
        <property type="interactions" value="457"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MBQ8"/>
    <dbReference type="GeneID" id="8105228"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119530"/>
    <dbReference type="eggNOG" id="KOG2637">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028555_1_0_1"/>
    <dbReference type="InParanoid" id="B8MBQ8"/>
    <dbReference type="OMA" id="TAQHFTL"/>
    <dbReference type="OrthoDB" id="5852896at2759"/>
    <dbReference type="PhylomeDB" id="B8MBQ8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007307">
        <property type="entry name" value="Ltv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531">
        <property type="entry name" value="LOW-TEMPERATURE VIABILITY PROTEIN LTV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531:SF0">
        <property type="entry name" value="PROTEIN LTV1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04180">
        <property type="entry name" value="LTV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED18191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="496" mass="54361" checksum="034A709CF754FB9D" modified="2009-03-03" version="1">MPPRRWIDKKNATTYQLFHRSQQDPLIHDPTADDRVLHPVYGPKQGAPALSTTASSASHKTSRNLKELESEFSTENVRKNEGEAANYGIYYDDSKYDYMQHLRELGTAGGNSYFVEAAPDKAKGKGKGMKLEDALRDFSIDDSRSEIGGSASVYGSEYARSTASSYVRKPTYQDQQDVPDVIAGFQPNMDPRLREALEALDDEAFVDDEDDHDIFGELTRNAEEVDPEEFQDTLYEDEDDGWESDATEKAYPQTSDTKTAGQNDNEATVAQQHDPSEMPDHDKPVPDLAPENADWMREFAKFKKEGKTLNNTPAANPDAGTEKHTVASTLFTVGGTPIRKKKRKGALTNPSAYSMTSSALARTEGLRLLDDRFERVEALYALDEEGEYDDASCADGASMISGMTGATGMTGMSAASSQAPSLVSRGGDYSNAPLPSNFDNVMDDFLSGWQDRSKQAKRKGAKGKRGKNGNEVLGIAMLDEIRQGLGPARVPARGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBR2</accession>
    <name>B8MBR2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein RIX1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_119570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RIX1/PELP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482187.1">
        <property type="nucleotide sequence ID" value="XM_002482142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBR2"/>
    <dbReference type="FunCoup" id="B8MBR2">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MBR2"/>
    <dbReference type="GeneID" id="8105232"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119570"/>
    <dbReference type="eggNOG" id="ENOG502S31T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016392_1_0_1"/>
    <dbReference type="InParanoid" id="B8MBR2"/>
    <dbReference type="OMA" id="GGWEILR"/>
    <dbReference type="OrthoDB" id="20900at2759"/>
    <dbReference type="PhylomeDB" id="B8MBR2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012583">
        <property type="entry name" value="RIX1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105:SF1">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08167">
        <property type="entry name" value="RIX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein RIX1 N-terminal" evidence="6">
        <location>
            <begin position="7"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="653"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="720"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="653"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="673"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="759"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="775"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED18195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="784" mass="85473" checksum="B90801798311D65F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBS0</accession>
    <name>B8MBS0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Transcription elongation factor SPT4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_119650</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SPT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482195.1">
        <property type="nucleotide sequence ID" value="XM_002482150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBS0"/>
    <dbReference type="FunCoup" id="B8MBS0">
        <property type="interactions" value="445"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MBS0"/>
    <dbReference type="GeneID" id="8105240"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119650"/>
    <dbReference type="eggNOG" id="KOG3490">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138052_2_0_1"/>
    <dbReference type="InParanoid" id="B8MBS0"/>
    <dbReference type="OMA" id="FDGMIAV"/>
    <dbReference type="OrthoDB" id="248751at2759"/>
    <dbReference type="PhylomeDB" id="B8MBS0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001208">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001209">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000232">
        <property type="term" value="P:regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090262">
        <property type="term" value="P:regulation of transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07973">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009287">
        <property type="entry name" value="Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038510">
        <property type="entry name" value="Spt4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882">
        <property type="entry name" value="SUPPRESSOR OF TY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025023">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0137">Centromere</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="9">
        <location>
            <begin position="14"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR025023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED18203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="121" mass="13392" checksum="26EBB1849234C85F" modified="2009-03-03" version="1">MTSFVVPPGQIRTLRACMVCSVVMPQSKFAREGCPNCEHVLQLRGNNDAIQECTSQVFEGLISIIDERQSWVARWQRLEGYVPGTYAIKVTGTLPTETIASLEDAGIKYIPRDGSANEEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBZ2</accession>
    <name>B8MBZ2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">60S ribosomal protein L23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_121770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482430.1">
        <property type="nucleotide sequence ID" value="XM_002482385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBZ2"/>
    <dbReference type="FunCoup" id="B8MBZ2">
        <property type="interactions" value="768"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MBZ2"/>
    <dbReference type="GeneID" id="8098166"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_121770"/>
    <dbReference type="eggNOG" id="KOG1751">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037562_0_1_1"/>
    <dbReference type="InParanoid" id="B8MBZ2"/>
    <dbReference type="OMA" id="RLDHHKV"/>
    <dbReference type="OrthoDB" id="1267328at2759"/>
    <dbReference type="PhylomeDB" id="B8MBZ2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000035">
        <property type="entry name" value="60S ribosomal protein L23a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_uL23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005633">
        <property type="entry name" value="Ribosomal_uL23_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011118">
        <property type="entry name" value="PRK14548.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L23A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03939">
        <property type="entry name" value="Ribosomal_L23eN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL23 N-terminal" evidence="7">
        <location>
            <begin position="13"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED18438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="152" mass="16762" checksum="E72CA093CE10821E" modified="2009-03-03" version="1">MAGEKKGAKVKPSNKAGAAAKAVLKGQGAKKLRKIRTSTTFHLPKTLQLSRSPKYPRKSVPHEPRLDHHKVIIHPLNTESAMKKIEENNTLVFIVDVKANKRQIKAALKKLYDVDTVKINTLIRPDGSKKAYARLTPDVDALDIAATKLAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCV9</accession>
    <name>B8MCV9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_113110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481477.1">
        <property type="nucleotide sequence ID" value="XM_002481432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCV9"/>
    <dbReference type="STRING" id="441959.B8MCV9"/>
    <dbReference type="GeneID" id="8101623"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_113110"/>
    <dbReference type="eggNOG" id="ENOG502S3QT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023133_1_0_1"/>
    <dbReference type="InParanoid" id="B8MCV9"/>
    <dbReference type="OMA" id="DAPEERW"/>
    <dbReference type="OrthoDB" id="5590473at2759"/>
    <dbReference type="PhylomeDB" id="B8MCV9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18724">
        <property type="entry name" value="PIN_LabA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007681">
        <property type="entry name" value="Mog1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837:SF5">
        <property type="entry name" value="NYN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="49701" checksum="00EA23755F12A546" modified="2009-03-03" version="1">MQSSDGPSAWDFTAVIDLVYTPTRPQTNPTRGSPDPSLSDNEADVLRQNPRDHGLGDFTALWDFLHPPAVNGKNAPITPKRQSLDKTYPSPSKPISILKRPSKAITQDSSTASGALSDSTTESDGDASVFDSTVSSKSALSLIPSQVARTAKSQPLLTPPSSCEEDSTLSAYTPKAKKLPTSRYKSAVERKAELISKLSKQFPDFTISPPSIFNAPKQSPAVHIFVDASNISIGLHDSYKIQHNIPVTTHIKRLPLSFHNFSLILERGRPVAKKVLAGSDRFPAINEAEKLGYEVNILSRVHKAKEYTPRQLKFRNALDPGTSPEMGPSPSERWVEQCVDEILHLKMLESLIDSDEPATIVLATGDAAEAEYSGGFLRMVERALQKGWSVELVSFAMNTSFAYKRKEFRAKWGKRFRMINLEDYVEEMLDMTVTDVFGRREKMKEFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8MD87</accession>
    <name>B8MD87_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Septin AspA, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_114250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481604.1">
        <property type="nucleotide sequence ID" value="XM_002481559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MD87"/>
    <dbReference type="FunCoup" id="B8MD87">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MD87"/>
    <dbReference type="GeneID" id="8109187"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_114250"/>
    <dbReference type="eggNOG" id="KOG2655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017718_7_4_1"/>
    <dbReference type="InParanoid" id="B8MD87"/>
    <dbReference type="OMA" id="GYDSAMN"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="PhylomeDB" id="B8MD87"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000328">
        <property type="entry name" value="Septin spn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="17"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED17612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="385" mass="43768" checksum="1E8B96EB3F920502" modified="2009-03-03" version="1">MMSSPLNAIRRKKNVKKGIQFCLMVCGASGTGRTTFVNTLCGKKVLEHKDADDAANAHIEEGVRIKPVTVELELDEEGTRISLTIVDTPGFGDQIDNEASFSEIVGYLERQYDDILAMESRIKRNPRFRDNRVHVLLYFITPTGHGLRELDIELMKRLSPRVNVIPVIGKADSLTPAELAESKKLVMEDIEHYRIPVYNFPYDIEEDDEDTVEENAELRGLMPFAIVGSEEVLEIGGKKVRARQYPWGIVEVENPRHSDFLAIRSALLHSHLADLKEITHDFLYENYRTEKLSKSVDGGAGSNEDSSMNPEDLVSQSVRLKEEQLRREEEKLREIELRVQREINEKRQELLARESQLREIEARMQREASAHLAATEETNGEAGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDM6</accession>
    <name>B8MDM6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_120090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482247.1">
        <property type="nucleotide sequence ID" value="XM_002482202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MDM6"/>
    <dbReference type="FunCoup" id="B8MDM6">
        <property type="interactions" value="78"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MDM6"/>
    <dbReference type="GeneID" id="8105283"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_120090"/>
    <dbReference type="eggNOG" id="KOG3928">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046315_1_0_1"/>
    <dbReference type="InParanoid" id="B8MDM6"/>
    <dbReference type="OMA" id="GLAHWMT"/>
    <dbReference type="OrthoDB" id="274828at2759"/>
    <dbReference type="PhylomeDB" id="B8MDM6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019368">
        <property type="entry name" value="Ribosomal_mS29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10236">
        <property type="entry name" value="DAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="50"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED18255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="518" mass="57432" checksum="E9E3A146404EDE38" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEL0</accession>
    <name>B8MEL0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Polyketide synthase, putative</fullName>
            <ecNumber evidence="13">2.3.1.161</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_017120</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the C-terminal section; belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.161" evidence="13"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483871.1">
        <property type="nucleotide sequence ID" value="XM_002483826.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MEL0"/>
    <dbReference type="GeneID" id="8103685"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_017120"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_31_0_1"/>
    <dbReference type="InParanoid" id="B8MEL0"/>
    <dbReference type="OMA" id="SWFLKNF"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="PhylomeDB" id="B8MEL0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050637">
        <property type="term" value="F:lovastatin nonaketide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000019">
        <property type="entry name" value="Polyketide synthase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="6"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="942"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2405"/>
            <end position="2480"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="942"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1093"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2525"/>
            <end position="2544"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="974"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED16637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="2900" mass="319164" checksum="55526C3973564EA2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFV6</accession>
    <name>B8MFV6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_009450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483057.1">
        <property type="nucleotide sequence ID" value="XM_002483012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFV6"/>
    <dbReference type="GeneID" id="8100806"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_009450"/>
    <dbReference type="eggNOG" id="KOG1121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009123_4_0_1"/>
    <dbReference type="InParanoid" id="B8MFV6"/>
    <dbReference type="OrthoDB" id="2976890at2759"/>
    <dbReference type="PhylomeDB" id="B8MFV6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23272">
        <property type="entry name" value="BED FINGER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23272:SF161">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN RICESLEEPER 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="202"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="388" mass="44473" checksum="CE87C5D2D8AC5C03" modified="2009-03-03" version="1">MLNDAWNAAPQIQEYLKMNHILPPFTDQDWNQLGQIRIVLAEFDRYILELSTDIPQISQSLAIYYQLFDLLQEVQEREGKFKDFDADVANAAKSAMRKYDKYYTLMDDLCDILYITMLLDPRFKKLVLEHELRDEAQDIITAMQEQLEIQYPITHKPELFIASEEPGPSVTLQNPDKTIVSEMISKIKAKSQKSAEKPSDIARYLNSDVVEFDEKKRDWIYTWWRGHIDEYPRMAAAARDYLAVPAAEVNIERLFNTGRDLLGLRRWSLSSGTMRKLLILKDSLCKRGTCEFPLPVSFAVGGLALPYAVLSPPPSRIRDYINPIPRHFNLAPFYFCIFLSVAGVIVLTGPADLQLVSTIVAFTVAMHGQAIAPSLHSWYHFPSFCELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MG05</accession>
    <name>B8MG05_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_009900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483106.1">
        <property type="nucleotide sequence ID" value="XM_002483061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MG05"/>
    <dbReference type="GeneID" id="8102786"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_009900"/>
    <dbReference type="HOGENOM" id="CLU_013929_8_0_1"/>
    <dbReference type="InParanoid" id="B8MG05"/>
    <dbReference type="OMA" id="GITHRCW"/>
    <dbReference type="OrthoDB" id="4207519at2759"/>
    <dbReference type="PhylomeDB" id="B8MG05"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="218" mass="25465" checksum="52ED116B03FC42ED" modified="2009-03-03" version="1">MPPIRNKNKKDLAEQEGQILLAISDLQNGRIFRVAQAARIYSIPRATLRDRLNGTQQRSQVRANSHKLTQCEEESLVKWILDLDKQIESKFSRKYNYERAKCEDPKIIQEYFDRVREVILQYGILPEDIYNFDEPGFAMGLCANAKVITGSDRYARPKLLQPGNREWVTAIEAVNSIGWALLSYIIFKAKKYTRLGWFEDFPDDWKINISDNGWMDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGK6</accession>
    <name>B8MGK6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integral membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_018280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483991.1">
        <property type="nucleotide sequence ID" value="XM_002483946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGK6"/>
    <dbReference type="GeneID" id="8100938"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_018280"/>
    <dbReference type="eggNOG" id="ENOG502RZUI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033354_0_0_1"/>
    <dbReference type="InParanoid" id="B8MGK6"/>
    <dbReference type="OMA" id="AICRIYC"/>
    <dbReference type="OrthoDB" id="5553410at2759"/>
    <dbReference type="PhylomeDB" id="B8MGK6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.10">
        <property type="entry name" value="PNP-oxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019595">
        <property type="entry name" value="DUF2470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037119">
        <property type="entry name" value="Haem_oxidase_HugZ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37783">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04315)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37783:SF1">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04315)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10615">
        <property type="entry name" value="DUF2470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2470" evidence="3">
        <location>
            <begin position="162"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED16757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="384" mass="43936" checksum="84592BE1249811A5" modified="2009-03-03" version="1">MSAPTAEKQKKEDNPPQEEDDYYSEGDSDYDYSDDDPDEPMTESDAENDGQLRRKARGRRRNDKYYGDEDDYSNEYDDDDDDDDYDDDDDNAVAPYGGSAMRDQQQQQGGGKMELASDAKKGIDDEEGLKLKLEVNLDVEIELKAAIHGDLTLSLLKDQVQQQRIITHMNNDHRNTLSLFLEVYNKVPYSQAQTARIEEIRLIGMTISTADNPNSTKSSRTNFLVPFEPALNRYEDARHRVVEMHKHCLKTLGRSDITIQEYRRPRGLGAVLFTICLTVFIAFSRRSNFQPDSALYSNVLGHFPGFATFCYKIQPLLISVMAGIHLSEAAYLAVYRLRPHSVPFGSRVWFLWVVNDFIEGFTTLQRFDALIEEKRALKAQHKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGS7</accession>
    <name>B8MGS7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_014050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483542.1">
        <property type="nucleotide sequence ID" value="XM_002483497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGS7"/>
    <dbReference type="STRING" id="441959.B8MGS7"/>
    <dbReference type="GeneID" id="8099204"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_014050"/>
    <dbReference type="eggNOG" id="ENOG502SMMM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007003_3_2_1"/>
    <dbReference type="InParanoid" id="B8MGS7"/>
    <dbReference type="OMA" id="NAIFACC"/>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="PhylomeDB" id="B8MGS7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF86">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
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</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B8MH21</accession>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484067.1">
        <property type="nucleotide sequence ID" value="XM_002484022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MH21"/>
    <dbReference type="FunCoup" id="B8MH21">
        <property type="interactions" value="1008"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MH21"/>
    <dbReference type="GeneID" id="8104595"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_018990"/>
    <dbReference type="eggNOG" id="KOG0374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_8_3_1"/>
    <dbReference type="InParanoid" id="B8MH21"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="PhylomeDB" id="B8MH21"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000007">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="120"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED16833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="324" mass="37248" checksum="2440696728672328" modified="2009-03-03" version="1">MADQDVDLDSIIDRLLEVRGSRPGKQVQLLESEIRHLCTKAREIFISQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFTMHGGLSPDLNSMEQIRRVMRPTDIPDCGLLCDLLWSDPDKDITGWSENDRGVSFTFGPDVVSRFLQKHDMDLICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQILKPAEKKQKYVHGGISTGRPITPPRKQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHC1</accession>
    <name>B8MHC1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor CWC22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-mRNA-splicing factor cwc22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_021570</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484334.1">
        <property type="nucleotide sequence ID" value="XM_002484289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHC1"/>
    <dbReference type="FunCoup" id="B8MHC1">
        <property type="interactions" value="892"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MHC1"/>
    <dbReference type="GeneID" id="8098423"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_021570"/>
    <dbReference type="eggNOG" id="KOG2140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006308_3_2_1"/>
    <dbReference type="InParanoid" id="B8MHC1"/>
    <dbReference type="OMA" id="ILTEDMR"/>
    <dbReference type="OrthoDB" id="3938623at2759"/>
    <dbReference type="PhylomeDB" id="B8MHC1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000004">
        <property type="entry name" value="pre-mRNA-splicing factor CWC22 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="MI" evidence="10">
        <location>
            <begin position="427"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="391"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="622"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="51"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="636"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED17100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="798" mass="90896" checksum="4CB3A4C4CC9965A5" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHY7</accession>
    <name>B8MHY7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Glucose-6-phosphate 1-epimerase</fullName>
            <ecNumber evidence="3 5">5.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_015540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:16249"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58247"/>
            <dbReference type="EC" id="5.1.3.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glucose-6-phosphate 1-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.15" evidence="3 5"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483701.1">
        <property type="nucleotide sequence ID" value="XM_002483656.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="B8MHY7">
        <property type="interactions" value="276"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MHY7"/>
    <dbReference type="GeneID" id="8106295"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_015540"/>
    <dbReference type="eggNOG" id="KOG1594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048345_1_0_1"/>
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    <dbReference type="OMA" id="TQALHSY"/>
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    <dbReference type="PhylomeDB" id="B8MHY7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd09020">
        <property type="entry name" value="D-hex-6-P-epi_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
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        <property type="entry name" value="G6P_1-epimerase"/>
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    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122">
        <property type="entry name" value="APOSPORY-ASSOCIATED PROTEIN C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122:SF13">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016020">
        <property type="entry name" value="PHexose_mutarotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED16467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="315" mass="34300" checksum="0492A9A15EDF88C5" modified="2009-03-03" version="1">MDRSKKPTSIGIGGSIPQPTVNINDNGTVDAKLPSGESVTVHLFGATVISWKLANGAEQLFVSSKAILDGSKAIRGGIPVVFPVFGPPPPDHATSKLPQHGFARSSNWEFLGKSSSESLGDKADTTVKLDFGLSSSMITEEFRKAWPYEFGLVYSVTLSPESLETSLQVQNKGTESFDFHVLLHNYFKVPDVTKIGVTNLQNKTYIDKVDNKQEKQETSDAIAITGETDRVYLDVDPATPVSVVENGKPLFTIAREGLNTVTVWNPWLENAKKMSDFGDEEYKGMVCVEPGAVKSFSVLEGGDAWEGTQTIRPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MI28</accession>
    <name>B8MI28_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Extracellular serine-rich protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_022440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484424.1">
        <property type="nucleotide sequence ID" value="XM_002484379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MI28"/>
    <dbReference type="STRING" id="441959.B8MI28"/>
    <dbReference type="GeneID" id="8107081"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_022440"/>
    <dbReference type="eggNOG" id="ENOG502S40X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053381_4_0_1"/>
    <dbReference type="InParanoid" id="B8MI28"/>
    <dbReference type="OMA" id="SEDPIWY"/>
    <dbReference type="OrthoDB" id="2331100at2759"/>
    <dbReference type="PhylomeDB" id="B8MI28"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF15">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877603" evidence="3">
        <location>
            <begin position="20"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Blue (type 1) copper" evidence="4">
        <location>
            <begin position="50"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED17190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="230" mass="23306" checksum="2B76434E5B4F1B43" modified="2009-03-03" version="1">MVQILRSISILCWVALVSAQYGNPGTTAKSATTTSVVPSSTSSSTAVQTIAVGKNGFTFDPDTLTVSPGGKVEFHFYPGPHSVARASFENPCHPTIQTGIFSGSVPGSNGGSSTVLTLTINDTNPIWYYCGEPGHCQAGMVGVINPPSNGSNTITAFKASAANANGSTVPASVAGGVWGASTSGLPTSSQAASGISSSSPTPTGEARTLHAWTDMSTILIFSVLVALCMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8MI60</accession>
    <name>B8MI60_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_022760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484456.1">
        <property type="nucleotide sequence ID" value="XM_002484411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MI60"/>
    <dbReference type="STRING" id="441959.B8MI60"/>
    <dbReference type="GeneID" id="8107113"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_022760"/>
    <dbReference type="eggNOG" id="ENOG502RPIP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1908103_0_0_1"/>
    <dbReference type="InParanoid" id="B8MI60"/>
    <dbReference type="OrthoDB" id="5400577at2759"/>
    <dbReference type="PhylomeDB" id="B8MI60"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED17222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="133" mass="15445" checksum="038BF32FD6A12439" modified="2009-03-03" version="1">MSLISGGYKFGPGCATPNHTLIKEFLRWYIHIAKGKISKSGRVVTFMVLNFTERLFGGFKENMQVTIAPKDRSKIFHWIKRTLTEEEKAIENVKDLDYSFMKRDFLRVIASMWQADQRQFMPSLLKAIIILAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIF6</accession>
    <name>B8MIF6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase subgroup catalytic core protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_041180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484593.1">
        <property type="nucleotide sequence ID" value="XM_002484548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIF6"/>
    <dbReference type="STRING" id="441959.B8MIF6"/>
    <dbReference type="GeneID" id="8109703"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_041180"/>
    <dbReference type="eggNOG" id="ENOG502RG5A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022442_0_0_1"/>
    <dbReference type="InParanoid" id="B8MIF6"/>
    <dbReference type="OMA" id="WPRWCGK"/>
    <dbReference type="OrthoDB" id="2338662at2759"/>
    <dbReference type="PhylomeDB" id="B8MIF6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877760" description="Glycoside hydrolase subgroup catalytic core protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="62427" checksum="BADABE9DDD726E52" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIH3</accession>
    <name>B8MIH3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc knuckle domain protein (Byr3), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_045270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485018.1">
        <property type="nucleotide sequence ID" value="XM_002484973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIH3"/>
    <dbReference type="STRING" id="441959.B8MIH3"/>
    <dbReference type="GeneID" id="8099491"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_045270"/>
    <dbReference type="eggNOG" id="KOG4400">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058879_2_0_1"/>
    <dbReference type="InParanoid" id="B8MIH3"/>
    <dbReference type="OMA" id="KGNPTCY"/>
    <dbReference type="OrthoDB" id="3863715at2759"/>
    <dbReference type="PhylomeDB" id="B8MIH3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000023">
        <property type="entry name" value="Cellular nucleic acid-binding protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051714">
        <property type="entry name" value="Znf_CCHC_NABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23002">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED15065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="181" mass="18989" checksum="FA68AAB581228D2B" modified="2009-03-03" version="1">MENQTGSRGCFNCGEPSHQARDCPKKGTPTCYNCGGQGHVSRECTQAPKEKSCYRCGQTGHISRDCQQSGPANNGGNYRGGFSGGSGGQECYKCGQVGHIARNCSQGGGYGGGHGGFGGRQQTCYSCGGYGHMARDCTQGQKCYNCGEVGHVSRDCTTEGNGERVCYKCKQPGHVQSACPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIU0</accession>
    <name>B8MIU0_TALSN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_050410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002485510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIU0"/>
    <dbReference type="GeneID" id="8109083"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_050410"/>
    <dbReference type="eggNOG" id="ENOG502T6QT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058490_3_2_1"/>
    <dbReference type="InParanoid" id="B8MIU0"/>
    <dbReference type="OMA" id="HWWLEAE"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="PhylomeDB" id="B8MIU0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED15602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="293" mass="33110" checksum="8DB603CD92290105" modified="2009-03-03" version="1">MAFLRSISNASLSSSSELSYSEFSSVESESEDPLAQLAKEVKQQPYTTNESLQKSLERRQRALQQDQTRDQHLVFTRFFFNAETRILIAKVMPNPAHELAIISFDSLISLELRAMNVHRDVRPFGSTTTTVGNWKKEADCCWAPASTNARLSFVVEVGLLESERQLALDARSWLETYSSSVKLVVTISIKRENPDITFHRWELVPQAYGVATRSSPLSARHTAILKLSRTNNTTSVTGESYINSTTTTTTQLDLSFDKVVGRPPHRPLERDLVIPEQELRSFAEDIWSEQSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJ25</accession>
    <name>B8MJ25_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase Tc1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_051250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485640.1">
        <property type="nucleotide sequence ID" value="XM_002485595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJ25"/>
    <dbReference type="STRING" id="441959.B8MJ25"/>
    <dbReference type="GeneID" id="8106327"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_051250"/>
    <dbReference type="HOGENOM" id="CLU_033666_3_0_1"/>
    <dbReference type="InParanoid" id="B8MJ25"/>
    <dbReference type="OrthoDB" id="4737581at2759"/>
    <dbReference type="PhylomeDB" id="B8MJ25"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="16932" checksum="859BDE6DFE90578F" modified="2009-03-03" version="1" fragment="single">MTTIRNTIKKEQERINQRSKTRSGAPAKLTEEDKQKLIDLTTQNPHIKYEELRNAVDNKVTIRTIQNMFQQIHKRKWKQPWALRYETYTPREWQRILWSDECTVERGKGGQLIWTWHSLSEQLQEHDIREIRTGMSIKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJ59</accession>
    <name>B8MJ59_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_051580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485674.1">
        <property type="nucleotide sequence ID" value="XM_002485629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJ59"/>
    <dbReference type="STRING" id="441959.B8MJ59"/>
    <dbReference type="GeneID" id="8103379"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_051580"/>
    <dbReference type="eggNOG" id="KOG0228">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013784_3_0_1"/>
    <dbReference type="InParanoid" id="B8MJ59"/>
    <dbReference type="OMA" id="YGINWEC"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="PhylomeDB" id="B8MJ59"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18621">
        <property type="entry name" value="GH32_XdINV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF3">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 32 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="6">
        <location>
            <begin position="18"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="7">
        <location>
            <begin position="435"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED15721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="680" mass="76738" checksum="9D577B3A5BB21C27" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKG3</accession>
    <name>B8MKG3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_047640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485271.1">
        <property type="nucleotide sequence ID" value="XM_002485226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKG3"/>
    <dbReference type="STRING" id="441959.B8MKG3"/>
    <dbReference type="GeneID" id="8099314"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_047640"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073132_0_0_1"/>
    <dbReference type="InParanoid" id="B8MKG3"/>
    <dbReference type="OrthoDB" id="4509351at2759"/>
    <dbReference type="PhylomeDB" id="B8MKG3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED15318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24047" checksum="1E9440F8E664809C" modified="2009-03-03" version="1">MAETVALRKPEQEDYTQVKSYRPMALLNTLASFLTERQTTIKLREATSGILNVETGIPQGSPLSPILYLFFNADLIEKCYNPSNNTGTQVQQNNRQGTPNLAGRLRSEANNKLNWNGHIEHIETKMTKSLGALSSLAGSTWGTGYKGLRQVYQATILPQIIYAASIWYAPLNLEDNHREKAVGKLEAIQKKVARIITEAFKTVSGAALDIEAFLLPI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2023-11-08" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKY6</accession>
    <name>TSTA_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Highly reducing polyketide synthase tstA</fullName>
            <shortName evidence="9">HR-PKS phiA</shortName>
            <ecNumber evidence="6">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Phomoidride biosynthesis cluster protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tstA</name>
        <name type="ORF">TSTA_048430</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1997" name="J. Antibiot." volume="50" first="1" last="7">
            <title>CP-225,917 and CP-263,114, novel Ras farnesylation inhibitors from an unidentified fungus. I. Taxonomy, fermentation, isolation, and biochemical properties.</title>
            <authorList>
                <person name="Dabrah T.T."/>
                <person name="Harwood H.J. Jr."/>
                <person name="Huang L.H."/>
                <person name="Jankovich N.D."/>
                <person name="Kaneko T."/>
                <person name="Li J.C."/>
                <person name="Lindsey S."/>
                <person name="Moshier P.M."/>
                <person name="Subashi T.A."/>
                <person name="Therrien M."/>
                <person name="Watts P.C."/>
            </authorList>
            <dbReference type="PubMed" id="9066758"/>
            <dbReference type="DOI" id="10.7164/antibiotics.50.1"/>
        </citation>
        <scope>BIOTECHNOLOGY</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="Org. Lett." volume="17" first="5658" last="5661">
            <title>Biosynthetic study on antihypercholesterolemic agent phomoidride: general biogenesis of fungal dimeric anhydrides.</title>
            <authorList>
                <person name="Fujii R."/>
                <person name="Matsu Y."/>
                <person name="Minami A."/>
                <person name="Nagamine S."/>
                <person name="Takeuchi I."/>
                <person name="Gomi K."/>
                <person name="Oikawa H."/>
            </authorList>
            <dbReference type="PubMed" id="26558485"/>
            <dbReference type="DOI" id="10.1021/acs.orglett.5b02934"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2022" name="J. Am. Chem. Soc." volume="144" first="20998" last="21004">
            <title>Elucidation of late-stage biosynthesis of phomoidride: proposal of cyclization mechanism affording characteristic nine-membered ring of fungal dimeric anhydride.</title>
            <authorList>
                <person name="Yamamoto S."/>
                <person name="Matsuyama T."/>
                <person name="Ozaki T."/>
                <person name="Takino J."/>
                <person name="Sato H."/>
                <person name="Uchiyama M."/>
                <person name="Minami A."/>
                <person name="Oikawa H."/>
            </authorList>
            <dbReference type="PubMed" id="36374185"/>
            <dbReference type="DOI" id="10.1021/jacs.2c09308"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="6 7">Highly reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of the antihypercholesterolemic agents phomoidrides which are dimeric anhydrides (PubMed:26558485, PubMed:36374185). The pathway begins with the highly reducing polyketide synthase tstA that catalyzes the formation of a C12-fatty acyl-ACP, starting from one acetate and 5 malonate units (PubMed:26558485, PubMed:36374185). The hydrolase tstM is involved in the release of the C12-fatty acyl chain from tstA. The alkylcitrate synthase (ACS) tstJ and the alkylcitrate dehydratase (ACDH) tstI then give rise to decarboxylated monomeric anhydrides by coupling the C12-fatty acyl chain with oxalacetic acid. The cyclase tstC is responsible for the dimerization of the monomeric anhydrides which leads to the production of prephomoidride that contains the characteristic bicyclo[4.3.1]deca-1,6-diene system of phomoidrides. Iterative oxidation catalyzed by the alpha-ketoglutarate-dependent dioxygenase tstK produced then phomoidride A. Finally, the methyltransferase tstE converts phomoidride A to phomoidride B via an acetalization reaction. The phosphatidylethanolamine-binding protein tstB and tstN are not essential for dimerization and their functions have still to be determined (PubMed:36374185).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6 7">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">Multidomain protein; including a ketosynthase (KS) that catalyzes repeated decarboxylative condensation to elongate the polyketide backbone; a malonyl-CoA:ACP transacylase (MAT) that selects and transfers the extender unit malonyl-CoA; a dehydratase (DH) domain that reduces hydroxyl groups to enoyl groups; a methyltransferase (CMeT) domain responsible for the incorporation of methyl groups; an enoylreductase (ER) domain that reduces enoyl groups to alkyl group; a ketoreductase (KR) domain that catalyzes beta-ketoreduction steps; and an acyl-carrier protein (ACP) that serves as the tether of the growing and completed polyketide via its phosphopantetheinyl arm. Involvement of a non methylated polyketide intermediate in the biosynthesis of phomoidride suggests that the cMET domain in tstA may be inactive.</text>
    </comment>
    <comment type="biotechnology">
        <text evidence="8">Phomoidrides A and B (also known as CP-225,917 and CP-263,114) are potent inhibitors of Ras farnesyltransferase and squalene synthase (PubMed:9066758). CP-225,917 and CP-263,114 inhibit Ras farnesyl transferase from rat brain with IC(50) values of 6 uM and 20 uoM, respectively (PubMed:9066758). CP-225,917 inhibits squalene synthase with an IC(50) value of 43 uM and CP-263,114 with an IC(50) of 160 uM (PubMed:9066758).</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="6"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485355.1">
        <property type="nucleotide sequence ID" value="XM_002485310.1"/>
    </dbReference>
    <dbReference type="SMR" id="B8MKY6"/>
    <dbReference type="STRING" id="441959.B8MKY6"/>
    <dbReference type="GeneID" id="8107025"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_048430"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_31_0_1"/>
    <dbReference type="InParanoid" id="B8MKY6"/>
    <dbReference type="OMA" id="WNHEAFY"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="PhylomeDB" id="B8MKY6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0596">Phosphopantetheine</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000458943" description="Highly reducing polyketide synthase tstA">
        <location>
            <begin position="1"/>
            <end position="2570"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="3 10">
        <location>
            <begin position="16"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="1 10">
        <location>
            <begin position="567"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="4 10">
        <location>
            <begin position="965"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1 10">
        <location>
            <begin position="1866"/>
            <end position="2178"/>
        </location>
    </feature>
    <feature type="domain" description="Ketoreductase (KR)" evidence="1 10">
        <location>
            <begin position="2202"/>
            <end position="2379"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="2 10">
        <location>
            <begin position="2482"/>
            <end position="2559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="4">
        <location>
            <begin position="965"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="4">
        <location>
            <begin position="1133"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Methyltransferase (CMeT) domain" evidence="1 10">
        <location>
            <begin position="1343"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="3">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="3">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="3">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="4">
        <location>
            <position position="997"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="4">
        <location>
            <position position="1198"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="2">
        <location>
            <position position="2519"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="26558485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="36374185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="9066758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="9">
        <source>
            <dbReference type="PubMed" id="26558485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="10">
        <source>
            <dbReference type="PubMed" id="26558485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED15402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="2570" mass="280373" checksum="DF4EF3917B2A9FED" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8ML60</accession>
    <name>B8ML60_TALSN</name>
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        <recommendedName>
            <fullName evidence="5">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_049150</name>
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    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002485384.1"/>
    </dbReference>
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    <dbReference type="STRING" id="441959.B8ML60"/>
    <dbReference type="GeneID" id="8100631"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_049150"/>
    <dbReference type="eggNOG" id="ENOG502S3YN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_303488_0_0_1"/>
    <dbReference type="InParanoid" id="B8ML60"/>
    <dbReference type="OMA" id="FGPAFPM"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="PhylomeDB" id="B8ML60"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398:SF4">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="5">
        <location>
            <begin position="741"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="236"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="488"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="790"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="906"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="800"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="917"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED15476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="939" mass="101350" checksum="F245438F95302AA3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8ML61</accession>
    <name>B8ML61_TALSN</name>
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        <submittedName>
            <fullName evidence="6">MFS sugar transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_044420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484929.1">
        <property type="nucleotide sequence ID" value="XM_002484884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ML61"/>
    <dbReference type="GeneID" id="8104118"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_044420"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="InParanoid" id="B8ML61"/>
    <dbReference type="OMA" id="WDMERAY"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="PhylomeDB" id="B8ML61"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF44">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED14976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="494" mass="53661" checksum="82B093104B2B07BA" modified="2009-03-03" version="1">MANRLNINFSVPELPPPPENWNVVQYGHGLYYTLEVALAAAAERRYSGALAHLHFFQGYDQGVIGGVNASSKYVTEVGIGKPDGTVTDTTHQGGVVLSAFTTWVLFSATLLGDAQNSNFMIYARVVTGIGTGALTGITPVLVSETSSADHRSGFLGCVVIANCKRALNPSSFWYSASLSRDISRILDLIRLAFLDSGRSDCFPALIPACCIKMLPDSSRYLASVDREEEARELLGRIRKHSASPEEIGREYLDIITLAEESQRSSPVLFARMALGKGGKQHPNSGRRAWLCVWLQIMASWTGITVGASTAFAACSPVLLPQVGYSAIKQNGLTGGINTIVDRLGRRVCLMAGSAILVNVNLVAGAVYEGSLHNPEKASQYASGAITMLLSSNIGYAATCGTVAFLLPTEIFLSHLQTQTVTVERHKASHTYFFFAGLNLLWIPIILSLSPETRNRSLESIEALFSTLNPFYWKMEQAYKLHGDVLAEHGRHRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8ML74</accession>
    <name>B8ML74_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NRPS-like enzyme, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_044550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484942.1">
        <property type="nucleotide sequence ID" value="XM_002484897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ML74"/>
    <dbReference type="STRING" id="441959.B8ML74"/>
    <dbReference type="GeneID" id="8104131"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_044550"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002220_2_1_1"/>
    <dbReference type="InParanoid" id="B8ML74"/>
    <dbReference type="OMA" id="RKTAYMW"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="PhylomeDB" id="B8ML74"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="37"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="4">
        <location>
            <begin position="662"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED14989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1032" mass="115034" checksum="1A6D370CEF5ED950" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLJ3</accession>
    <name>B8MLJ3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LSM complex subunit LSM4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LSM4</name>
        <name evidence="13" type="ORF">TSTA_049640</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485479.1">
        <property type="nucleotide sequence ID" value="XM_002485434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLJ3"/>
    <dbReference type="STRING" id="441959.B8MLJ3"/>
    <dbReference type="GeneID" id="8103420"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_049640"/>
    <dbReference type="eggNOG" id="KOG3293">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099537_2_2_1"/>
    <dbReference type="InParanoid" id="B8MLJ3"/>
    <dbReference type="OMA" id="RGAFGNR"/>
    <dbReference type="OrthoDB" id="747253at2759"/>
    <dbReference type="PhylomeDB" id="B8MLJ3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01723">
        <property type="entry name" value="LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000024">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034101">
        <property type="entry name" value="Lsm4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="79"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED15526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="118" mass="13041" checksum="8E9D7A8EC04EB606" modified="2009-03-03" version="1">MLPLGLLTAAQGHPMLVELKNGETLNGHLVNCDNWMNLTLKEVVQTTPEGDRFFRLPEVYVRGNNIKYLRVPEEILDVVREQQQHQPSNRGGRGGRGDGKDRGRGGRGGRGRGRGRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLN2</accession>
    <name>B8MLN2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 15">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSTA_101350</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 15"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486133.1">
        <property type="nucleotide sequence ID" value="XM_002486088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLN2"/>
    <dbReference type="FunCoup" id="B8MLN2">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MLN2"/>
    <dbReference type="GeneID" id="8101823"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_101350"/>
    <dbReference type="eggNOG" id="KOG3359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008438_2_2_1"/>
    <dbReference type="InParanoid" id="B8MLN2"/>
    <dbReference type="OMA" id="KNVTPRL"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="PhylomeDB" id="B8MLN2"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031502">
        <property type="term" value="C:dolichyl-phosphate-mannose-protein mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23283">
        <property type="entry name" value="beta-trefoil_MIR_PMT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000034">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF50">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 15 18" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="620"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="662"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="690"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="720"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="345"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="421"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="490"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="788"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="885"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="800"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="814"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="885"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EED13895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="946" mass="106170" checksum="68EE200D1F7289A5" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLP3</accession>
    <name>B8MLP3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-L-fucosidase</fullName>
            <ecNumber evidence="2">3.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_101460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 29 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.51" evidence="2"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486144.1">
        <property type="nucleotide sequence ID" value="XM_002486099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLP3"/>
    <dbReference type="STRING" id="441959.B8MLP3"/>
    <dbReference type="GeneID" id="8101834"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_101460"/>
    <dbReference type="eggNOG" id="KOG3340">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002934_4_1_1"/>
    <dbReference type="InParanoid" id="B8MLP3"/>
    <dbReference type="OMA" id="WWYSTHH"/>
    <dbReference type="OrthoDB" id="6039950at2759"/>
    <dbReference type="PhylomeDB" id="B8MLP3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057739">
        <property type="entry name" value="Glyco_hydro_29_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030:SF37">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002875314" description="alpha-L-fucosidase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 29 N-terminal" evidence="7">
        <location>
            <begin position="324"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED13906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="800" mass="89213" checksum="1F3D20530482B075" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MM27</accession>
    <name>B8MM27_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ndc10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_097950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485777.1">
        <property type="nucleotide sequence ID" value="XM_002485732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MM27"/>
    <dbReference type="GeneID" id="8108434"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_097950"/>
    <dbReference type="eggNOG" id="ENOG502RUBH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018052_0_0_1"/>
    <dbReference type="InParanoid" id="B8MM27"/>
    <dbReference type="OMA" id="LFWRWHV"/>
    <dbReference type="OrthoDB" id="4325529at2759"/>
    <dbReference type="PhylomeDB" id="B8MM27"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060963">
        <property type="term" value="P:positive regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.20">
        <property type="entry name" value="Centromere DNA-binding protein complex CBF3 subunit, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052146">
        <property type="entry name" value="HOT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038279">
        <property type="entry name" value="Ndc10_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031872">
        <property type="entry name" value="NDC10_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022210">
        <property type="entry name" value="TF_GCR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37784:SF2">
        <property type="entry name" value="HIGH-OSMOLARITY-INDUCED TRANSCRIPTION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37784">
        <property type="entry name" value="PROTEIN MSN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12550">
        <property type="entry name" value="GCR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16787">
        <property type="entry name" value="NDC10_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ndc10" evidence="2">
        <location>
            <begin position="253"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription activator GCR1-like" evidence="1">
        <location>
            <begin position="453"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED13539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="55082" checksum="7577C529564870A4" modified="2009-03-03" version="1">MQCGVTEIDALSRIAAGLIVRVDYAMDRLLSLLPRTAPLQIQVPNIATTKIEPPRPEDIAIQKALDEVLEYHRVHWPKNTTKNYEPKQKEWKAWCKKMGFKEGGRYLPGDYVDEGKLLLFIKEEVASRPPRRGQRLKAERKRKRTAAVEVLSEGPPSKRKREKISVPSMAFEELPIESDDDEACSELVLMYNTVRSYCSAINKLWAHQTLLGLHNAARPQRFTERGLATIRDGYVASQIPNLTRKIYSQCPYLMKGQKAKAGVLLLDSTAASWTRRLYSEAVIKSSKVTHAGRVSGARLAELNGVSEDQICWGGRWNADQMTDCYLTTLPRSFMRGIADFDPDWSSSYYLPRETVCPPPVLLKQYKAFELDIHMAVTTAMEEDPHSIAIQKAIPAVNDRLSTINDFISGTFTYQFVPRGQIVPPPITGAVFSPTAPIQLPVTALEKTSQAPQYRMSRNTTTIPELWKEWTVGLNGQLSIKRLDELYGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MM53</accession>
    <name>B8MM53_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl transferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_098220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485803.1">
        <property type="nucleotide sequence ID" value="XM_002485758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MM53"/>
    <dbReference type="STRING" id="441959.B8MM53"/>
    <dbReference type="GeneID" id="8108461"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_098220"/>
    <dbReference type="eggNOG" id="ENOG502S0TG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036369_2_0_1"/>
    <dbReference type="InParanoid" id="B8MM53"/>
    <dbReference type="OMA" id="PYITVMF"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="PhylomeDB" id="B8MM53"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF15">
        <property type="entry name" value="INOSITOL PHOSPHOCERAMIDE MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED13565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="350" mass="40247" checksum="7FB3E583CE1D2C2A" modified="2009-03-03" version="1">MTMPCLRVKIFIVVCVALFLSQKWWLPLGHTLFNLVALSSRWRQASVQSFISKDRDDFDVTFASYPVNQSTAGSGYQDLIPPILHHIHLGPHEPRPEWMGARDECIRYHPNWKAYIWDDDSAEKLVNEEFPHLSDMWKDYRYPVERVDALRYMVLQTYGGVVLDFDLACKRSLGPLRRFEFVAPAAHPTGFSIGFMMASQGNEFVRDLVDNLTRYNHVWFYLPYVAVMFSTGCHYASTIFTLQENRNPLRILGGITGSPRLHMLNGFVDTPLFRHLGSSSWHNFDAALINWIGHLRSGSIIISLIFVASLLLTVYVTRLCLRRRRCSAARDKAMGDRFDSERGFSCIKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MM65</accession>
    <name>B8MM65_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Choline monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_098340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485815.1">
        <property type="nucleotide sequence ID" value="XM_002485770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MM65"/>
    <dbReference type="STRING" id="441959.B8MM65"/>
    <dbReference type="GeneID" id="8099662"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_098340"/>
    <dbReference type="HOGENOM" id="CLU_1205472_0_0_1"/>
    <dbReference type="InParanoid" id="B8MM65"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="PhylomeDB" id="B8MM65"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF5">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="38"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED13577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="230" mass="26141" checksum="899308A0D9B783E8" modified="2009-03-03" version="1">MWQYLGCSSTTTDKEPPRGLPCIIISLRKRRAIFSKRWIFLIHSRRFTQQGDFLSYAVAKLSFFFVQDCDGSINGYHNICRYHAFPIVQARSVSTSILSCKYHGWSYGLRGNLSKAPRFETVSEFEESQHGLFPIYVHTDKIGSSGQVFKQASQTESMSKHGCKILTLLRTTHLITTIVENGLGCELEGGDRELQLSAIIAPLLIHSSVKCWNFLDIVSNPLRDIWNITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MM85</accession>
    <name>B8MM85_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_098540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485835.1">
        <property type="nucleotide sequence ID" value="XM_002485790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MM85"/>
    <dbReference type="FunCoup" id="B8MM85">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="GeneID" id="8099682"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_098540"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="InParanoid" id="B8MM85"/>
    <dbReference type="OMA" id="TSNRWAW"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="PhylomeDB" id="B8MM85"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF40">
        <property type="entry name" value="THIAMINE PATHWAY TRANSPORTER THI73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="55"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED13597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="505" mass="55260" checksum="7412685EA386F941" modified="2009-03-03" version="1">MIDTASKQAEVAAQQLPSGKRDDALRYLEEHNGISSAEVDAVNLKALRTKVDWHIVPLMFLCYFFQFIDKVIINYAAVMGISAELKLVGNDFTNASTSFFIAYLIAEVPNTLLLQKIPAGKWLGFNVIVWGIAVAATAGVKGYTTLVVARVFLGLFEATIGPSLMIISSQYYTKKEQAPRFSFWYLGLGVAQIIGGLISFGFQHVHHASISGWRIMFIVLGIVTSIVGAAVFFLIPDTPMKARFLTEVEKVALLRHVSENKTGVWNNKFNYEEIIEAIFDVQVWLLTLMVVLQSVSSGVVTTYSSTLIRNMGFSPKNAALLNMPSGFVSIVSTLAVGIGIRRADHRWAWVATCSIPGIIGGGLMSFLPKSNKAGCLIGIYLVNAIVAPLPVIYHWTAANCAGYTKRAFCSALVAGSFSIGNIIGPQTFQARDAPDYHPAKIAVLATQAAAGVLAVVLFGYYIWENKRRDARSASEPVVDTSSEDYKAEAWSGMTDKQNRSFRYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNF8</accession>
    <name>B8MNF8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-conjugating enzyme E2-16 kDa</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">E2 ubiquitin-conjugating enzyme 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-protein ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_102770</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="11">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486285.1">
        <property type="nucleotide sequence ID" value="XM_002486240.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486287.1">
        <property type="nucleotide sequence ID" value="XM_002486242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNF8"/>
    <dbReference type="FunCoup" id="B8MNF8">
        <property type="interactions" value="988"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MNF8"/>
    <dbReference type="GeneID" id="8101111"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_102770"/>
    <dbReference type="eggNOG" id="KOG0417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_13_3_1"/>
    <dbReference type="InParanoid" id="B8MNF8"/>
    <dbReference type="OMA" id="VHFTTRI"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000010">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2-16 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="12">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED14047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="147" mass="16470" checksum="E1A337912A3EF02E" modified="2009-03-03" version="1">MALKRINKELTDLGRDPPSSCSAGPIGDDLFHWQATIMGPSDSPYSGGVFFLAIHFPTDYPFKAPKVNFTTRIYHPNINSNGSICLDILRDQWSPALTISKVLLSICSMLTDPNPDDPLVPEIAHVYKTDRARYDATAREWTRKYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNI1</accession>
    <name>B8MNI1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MAP kinase kinase Ste7</fullName>
            <ecNumber evidence="10">2.7.12.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_102970</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002486263.1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_102970"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
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    <dbReference type="OMA" id="MIAKCLM"/>
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    <dbReference type="PhylomeDB" id="B8MNI1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="PKc_Byr1_like"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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    <dbReference type="InterPro" id="IPR017441">
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    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
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    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
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    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
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    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="67"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="355"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="412"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="512"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED14070.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="542" mass="59116" checksum="9694175E04CFCC3E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNM4</accession>
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        <submittedName>
            <fullName evidence="6">ZZ type zinc finger domain protein</fullName>
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        <name evidence="6" type="ORF">TSTA_103370</name>
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    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
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    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486351.1">
        <property type="nucleotide sequence ID" value="XM_002486306.1"/>
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    <dbReference type="AlphaFoldDB" id="B8MNM4"/>
    <dbReference type="STRING" id="441959.B8MNM4"/>
    <dbReference type="GeneID" id="8103040"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_103370"/>
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    <dbReference type="eggNOG" id="KOG4582">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_007590_0_0_1"/>
    <dbReference type="InParanoid" id="B8MNM4"/>
    <dbReference type="OMA" id="NKHGHHP"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="PhylomeDB" id="B8MNM4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14947">
        <property type="entry name" value="NBR1_like"/>
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    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ZZ_ZZZ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
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    <dbReference type="InterPro" id="IPR032350">
        <property type="entry name" value="Nbr1_FW"/>
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    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
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    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041981">
        <property type="entry name" value="ZZZ3_ZZ"/>
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    <dbReference type="PANTHER" id="PTHR20930">
        <property type="entry name" value="OVARIAN CARCINOMA ANTIGEN CA125-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930:SF0">
        <property type="entry name" value="PROTEIN ILRUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16158">
        <property type="entry name" value="N_BRCA1_IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="185"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="5">
        <location>
            <begin position="295"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="5">
        <location>
            <begin position="366"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="5">
        <location>
            <begin position="427"/>
            <end position="476"/>
        </location>
    </feature>
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        <location>
            <begin position="255"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="560"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="752"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="778"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED14113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="816" mass="90208" checksum="43488158006033F8" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MP08</accession>
    <name>B8MP08_TALSN</name>
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        <submittedName>
            <fullName evidence="8">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_104610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486485.1">
        <property type="nucleotide sequence ID" value="XM_002486440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MP08"/>
    <dbReference type="STRING" id="441959.B8MP08"/>
    <dbReference type="GeneID" id="8103232"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_104610"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_3_1"/>
    <dbReference type="InParanoid" id="B8MP08"/>
    <dbReference type="OMA" id="LFFVHHR"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="PhylomeDB" id="B8MP08"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF50">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="62"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED14247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="556" mass="62012" checksum="3185EA5249D2F9D1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPI8</accession>
    <name>B8MPI8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_106360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486665.1">
        <property type="nucleotide sequence ID" value="XM_002486620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPI8"/>
    <dbReference type="GeneID" id="8098888"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_106360"/>
    <dbReference type="eggNOG" id="ENOG502S3DG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036632_5_0_1"/>
    <dbReference type="InParanoid" id="B8MPI8"/>
    <dbReference type="OMA" id="QMAVPRK"/>
    <dbReference type="OrthoDB" id="3918601at2759"/>
    <dbReference type="PhylomeDB" id="B8MPI8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="2">
        <location>
            <begin position="35"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED14427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="334" mass="36631" checksum="09E5CCD3DC0FBCF7" modified="2009-03-03" version="1">MATPGVQITATNKSPLILIVTWLLLVLAAFAYIMRSIVKISRQAMHFGIDDYLLTGALVLCAAQSLATILRAADGFGKPFDTVSVEKVNKITEAGMAANVLYVVSLALSKLSLLLLLAKISPNKRHNQVMHGISLFVVLFTFISIFVVSFSCSVPKTWDYASGRCINRTVWWIVFDVYNIITEAALIFMPIYVIGLVQWPISRKVVVSTPFVLRICTIAACITDMVLWHNVSTTTDPYFAEWTVSVTTQVIQCSCLVCTCVLYLRNFLSSIETGFGLDGDLSASIPLKDRTTAGCNNLSSERLTGSMGMLGQIQVTTRYEVHTETDGLESGGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPN1</accession>
    <name>B8MPN1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_106800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486708.1">
        <property type="nucleotide sequence ID" value="XM_002486663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPN1"/>
    <dbReference type="GeneID" id="8103580"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_106800"/>
    <dbReference type="eggNOG" id="ENOG502RPQ3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083408_0_0_1"/>
    <dbReference type="InParanoid" id="B8MPN1"/>
    <dbReference type="OrthoDB" id="4260277at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="5"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="281" mass="32208" checksum="EDBBFA16DCB1F860" modified="2009-03-03" version="1">MTSDISPFSALPTELIIKVLMELPDLHSIHSLSRASRRVYEIYQDPQLQLQIIRSLILQAGDFSAEANLYSLLQTLKYIIKEKMDGWKPFAENGYEQLLIPFARVLAWSYASNKRKPEAVRLLKKIINQEEPFNSRDSLPKSSLTFLPLRMLLHRLRPKTQPPSMTQLERLREDVPVTEVRPGSVKWDVISEESRQTALSQKEIIFKKDLIMIKCSPRRSTLTAPTIYSMRYRWVSVCEHRTDSASVTAQTSIVSIGRRLALMSSANGLLFLTIDFVTLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQD1</accession>
    <name>B8MQD1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">monoamine oxidase</fullName>
            <ecNumber evidence="2">1.4.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_058220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.4" evidence="2"/>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487444.1">
        <property type="nucleotide sequence ID" value="XM_002487399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQD1"/>
    <dbReference type="STRING" id="441959.B8MQD1"/>
    <dbReference type="GeneID" id="8109243"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_058220"/>
    <dbReference type="eggNOG" id="KOG0029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2293572_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQD1"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="PhylomeDB" id="B8MQD1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF1">
        <property type="entry name" value="AMINE OXIDASE [FLAVIN-CONTAINING] B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="5">
        <location>
            <begin position="56"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED13333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="101" mass="10810" checksum="2D3BAF9EC522D7C3" modified="2009-03-03" version="1">MAPLSEGSFWTPTESMTGLGHAKDYDLGTGLETKTVQKSSPVLHDSYGVVVIGAGFTGVIAARELNQRHNLRVLLSEARDHIGGRTWTAKVLGEELEMGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQP2</accession>
    <name>B8MQP2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_059520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487576.1">
        <property type="nucleotide sequence ID" value="XM_002487531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQP2"/>
    <dbReference type="GeneID" id="8107421"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_059520"/>
    <dbReference type="HOGENOM" id="CLU_1200499_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQP2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="231" mass="25737" checksum="74129C3762474642" modified="2009-03-03" version="1">MQQSSIDERSQDRDPSKSRDIRSASLSPENFRSRTLTPAKNLPSPIRPNNDSAPLATIPAYIVDSDEPATTDRDNGDSGDELSDSGSSTPKASQHPQSLTSIYRPFDRPKPPPGRHRRGNQSVSSSSTPKPEVHQEQKVIDDMSNILQLGNARNQEDLGFGGDIISERSRQLTPARSLRREGRKACDYYDDDDYDEDSHEEVVKLRKEGEDDAIGRDLGSGLGFRKLLERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQU9</accession>
    <name>B8MQU9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_053020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486895.1">
        <property type="nucleotide sequence ID" value="XM_002486850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQU9"/>
    <dbReference type="GeneID" id="8098251"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_053020"/>
    <dbReference type="eggNOG" id="ENOG502RPNG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075632_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQU9"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="PhylomeDB" id="B8MQU9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="1">
        <location>
            <begin position="193"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="250" mass="27758" checksum="D58ADB9BBAC870CF" modified="2009-03-03" version="1">MDNIIFEDPSKRVSRKNKVGSNVALPVARCDMAIEQAPQPIDPYFSHDTNFNVYIHGKEPVSLFDMFSLSGDEELGNEDLTNESPQALSQGNINGQREWSVSVSREPAEEVIPIDPAILGKESVSEKNADENVALDCSGSSYPTSPKSLALHRHAQIVEDSAPVSDANSDTRRLPSKRRLAMKLIATPPANDAESRKGKSWEPDEIKLLVQLKEAGSPWSVIAKRFQERFPGRSKGSIQVYWSTKLQYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8MS45</accession>
    <name>B8MS45_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MIPC synthase subunit (SurA), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_004900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488104.1">
        <property type="nucleotide sequence ID" value="XM_002488059.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488105.1">
        <property type="nucleotide sequence ID" value="XM_002488060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MS45"/>
    <dbReference type="FunCoup" id="B8MS45">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MS45"/>
    <dbReference type="GeneID" id="8104474"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_004900"/>
    <dbReference type="eggNOG" id="ENOG502QS3D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8MS45"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000001">
        <property type="entry name" value="MIPC synthase subunit (SurA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF20">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE CSH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED12450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="351" mass="41217" checksum="E8AF1885F8D0D6D7" modified="2009-03-03" version="1">MRRGVVLFILVNVLILSFLVRSVFTLLTLLVEDASADAIHRSDIPSPNSSLIESRPQIIPKIIHQTYINESIPEHWIEPQQSCINLHPDYEYKLWTNEKSREFIAKEYPWFLETFDGYRYPIQRADAIRYFVLAYYGGTYIDLDDGCQRRLDPLLSYPAWVRRTKPTGISNDAMGAVPQHPFFLRVVESLQAYDKHWFLPYITVMYSTGPLFLSVVWKEYMAESFGMDRVRVLMPDEYNRFSWSFFTHHVGNSWHGADAQLIFWMCRYWVLLTVVGFTLAGCVGFCMWVVYRRLLLLGHRYRYTRLAPGGISVSKIRRRPFARMPRFFRRISSSSIYSDEESGRKEGAYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTF7</accession>
    <name>B8MTF7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GRF-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_003470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487943.1">
        <property type="nucleotide sequence ID" value="XM_002487898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTF7"/>
    <dbReference type="STRING" id="441959.B8MTF7"/>
    <dbReference type="GeneID" id="8098043"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_003470"/>
    <dbReference type="eggNOG" id="ENOG502SYR7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037645_1_0_1"/>
    <dbReference type="InParanoid" id="B8MTF7"/>
    <dbReference type="OMA" id="WFWTCAQ"/>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="PhylomeDB" id="B8MTF7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="7">
        <location>
            <begin position="28"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="305"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="168"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED12289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="349" mass="39048" checksum="8B10A4D2ECEF6116" modified="2009-03-03" version="1">MNQGSEIYSSPRRTSSWRGRFIDGVWHCDCDPRLPADHFQTKNGGVNHGRWFYTCQKPQPQRCKFFLWDDDAQIREKHTLLANSRSEPDTPKKSPSKSFQVGGLLTPGTGTTYGNSSAVKARTEPRRRLDFLAQQQTPTKVRKSSTLSSDEEAYSWDESLDNEAGNLLNRSSSSSTARPKQPVFTSNKAPRTATNTSPSKRKLQDVFDDEDKPPPYSESAPTTQSSSTAPISFSSVDVSATPTPRRYKDVLSAQGAASHQISDLASNILAILDRHDVVIPTIARDEIVASLDQHHLKTQGIIRGRDLSRMALKKKDEEIQALKERIERLETEREMDKVVISCLSDENSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTI9</accession>
    <name>B8MTI9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_004430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the Golgi-associated retrograde protein (GARP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS51 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488049.1">
        <property type="nucleotide sequence ID" value="XM_002488004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTI9"/>
    <dbReference type="STRING" id="441959.B8MTI9"/>
    <dbReference type="GeneID" id="8100154"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_004430"/>
    <dbReference type="eggNOG" id="KOG2346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043566_0_0_1"/>
    <dbReference type="InParanoid" id="B8MTI9"/>
    <dbReference type="OMA" id="YNLKPPG"/>
    <dbReference type="OrthoDB" id="203678at2759"/>
    <dbReference type="PhylomeDB" id="B8MTI9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
        <property type="entry name" value="Vps51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED12395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="335" mass="36713" checksum="D23968ECEB8ED81B" modified="2009-03-03" version="1">MSTISSPRLSTTSSHATSISSRRPSIDNSLNPNASTSGLGINNHTGSSINRAVSPAQRRNRAALRDYYNIKSSTGDEATSSATGAPRSTDASELFGSPSITVTSELDNPDFDAQKYIDQLLATSSLSTVLKAENTLVGDIRTLDGERKALVYDNYSKLIRAVETIGTMRRSMEERGAPLTMTKTLGPAVAFVAETASGLIKEGEELRRRVQDAKSKATGNKTAEQETVEWALGTPDRLRQYLREGQTEKAQEDWAEIDHLLQSWKGVKGVEELRAACEEIMKDQEKESVHVYGRCHDSILISQAKALSRECSHGHLSPNRMCSKLSYIRKLSYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTU8</accession>
    <name>B8MTU8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_005280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488145.1">
        <property type="nucleotide sequence ID" value="XM_002488100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTU8"/>
    <dbReference type="STRING" id="441959.B8MTU8"/>
    <dbReference type="GeneID" id="8105502"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_005280"/>
    <dbReference type="eggNOG" id="ENOG502SMUJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_497986_0_0_1"/>
    <dbReference type="InParanoid" id="B8MTU8"/>
    <dbReference type="OMA" id="IWFPMRY"/>
    <dbReference type="OrthoDB" id="5368516at2759"/>
    <dbReference type="PhylomeDB" id="B8MTU8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED12491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="544" mass="60334" checksum="4B668C7C65EB7790" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTX3</accession>
    <name>B8MTX3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_006160</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488241.1">
        <property type="nucleotide sequence ID" value="XM_002488196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTX3"/>
    <dbReference type="FunCoup" id="B8MTX3">
        <property type="interactions" value="897"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MTX3"/>
    <dbReference type="GeneID" id="8105301"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_006160"/>
    <dbReference type="eggNOG" id="KOG1257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011405_5_2_1"/>
    <dbReference type="InParanoid" id="B8MTX3"/>
    <dbReference type="OMA" id="QIVNHMV"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="PhylomeDB" id="B8MTX3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000001">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF34">
        <property type="entry name" value="NAD-DEPENDENT MALIC ENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="10">
        <location>
            <begin position="85"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="9">
        <location>
            <begin position="279"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED12587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="477" mass="53370" checksum="31087D6D9731B881" modified="2009-03-03" version="1">MTKFANLPRSASKPLECGLEGHALLHDSYFNKGSAFPSHERRDFGLHGLLPPNVQTLEEQVKRAYQQYSTRPDDLAKNTFMASMKAQNQVLYYRLIQDHLKEMFSVIYTPTEGDAIQNYSRIFRKPEGCFLNIHDVDRIEHDLKQFTENGTNEDVDYIVVTDGEEILGIGDQGVGSVLISVAKLVLTTLCAGIHPARQLPVVLDCGTDNETLLKDDLYLGLRHKRVRGEKYDRFVDRFVNSAKKIFPNAYIHFEDFGLHNARRLLEKYRPQIACFNDDVQGTGCVTLAALMAGLHVSKVKLADVRIVIFGSGTAGTGIADQIRDAIATESGKSKEEAAKQIWCIDKPGLLFKSHGDKLTPAQVHYARDDSEWEDHNQTDLYNVVKKVKPHALIGTSTKPNAFSEDIIREMANHVDRPIVFPLSNPTRLHEAHPNDINEWTEGKALIATGSPFPPVEYNGVKKKSRNAIIPPASPESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MU55</accession>
    <name>B8MU55_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nephrocystin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_109520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488529.1">
        <property type="nucleotide sequence ID" value="XM_002488484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MU55"/>
    <dbReference type="GeneID" id="8107184"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109520"/>
    <dbReference type="eggNOG" id="KOG1840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_125_15_1"/>
    <dbReference type="InParanoid" id="B8MU55"/>
    <dbReference type="OMA" id="REHHEFA"/>
    <dbReference type="OrthoDB" id="4227200at2759"/>
    <dbReference type="PhylomeDB" id="B8MU55"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="230" mass="27177" checksum="3C8FE4192D9609D4" modified="2009-03-03" version="1">MHSLVQLATRRWLEMNGKLETWKRQYIKNLKAEFPTGEYENWEHCQGRWKEAEELEVQVMEKRKSVLCVEYPDTLTSMDNLASTFWDQGRWKEAEELEVQVMEMSKRVLGVEHPDMLTSMDNLASTYWEQGRWKEAEELDVQMIEISKRVLGVEHPDMLTSMDNLASTYWEQGRWKEAEELEVQVMETRKRVMGVEHPDTLTSMANLAFTWKGQYRSAEALDLMKSCVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MU66</accession>
    <name>B8MU66_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_111000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488678.1">
        <property type="nucleotide sequence ID" value="XM_002488633.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488679.1">
        <property type="nucleotide sequence ID" value="XM_002488634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MU66"/>
    <dbReference type="GeneID" id="8110129"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_111000"/>
    <dbReference type="eggNOG" id="ENOG502S2ZX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_4_0_1"/>
    <dbReference type="InParanoid" id="B8MU66"/>
    <dbReference type="OMA" id="ENITAMF"/>
    <dbReference type="OrthoDB" id="4457643at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="60"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED11922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="548" mass="62699" checksum="C0265AF447CF8539" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUX6</accession>
    <name>B8MUX6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Benzoate 4-monooxygenase cytochrome P450, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_109230</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488500.1">
        <property type="nucleotide sequence ID" value="XM_002488455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUX6"/>
    <dbReference type="STRING" id="441959.B8MUX6"/>
    <dbReference type="GeneID" id="8107155"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109230"/>
    <dbReference type="eggNOG" id="KOG0159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_10_1"/>
    <dbReference type="InParanoid" id="B8MUX6"/>
    <dbReference type="OMA" id="IRKWIYL"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="PhylomeDB" id="B8MUX6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF112">
        <property type="entry name" value="L-ORNITHINE-N5-MONOOXYGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED11744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="567" mass="63268" checksum="F1902827A49AF020" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8MV56</accession>
    <name>B8MV56_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_008100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962662">
        <property type="protein sequence ID" value="EED11512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488693.1">
        <property type="nucleotide sequence ID" value="XM_002488648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MV56"/>
    <dbReference type="STRING" id="441959.B8MV56"/>
    <dbReference type="GeneID" id="8110147"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_008100"/>
    <dbReference type="eggNOG" id="KOG0351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001104_0_1_1"/>
    <dbReference type="InParanoid" id="B8MV56"/>
    <dbReference type="OMA" id="RYAVWAN"/>
    <dbReference type="OrthoDB" id="4353649at2759"/>
    <dbReference type="PhylomeDB" id="B8MV56"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022698">
        <property type="entry name" value="OrsD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12013">
        <property type="entry name" value="OrsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="340" mass="40111" checksum="5A32FEF933D88264" modified="2009-03-03" version="1">MMEFHNLMFERLTEFPVIVCRECRYAVWANQIEGHLKQAHRHILMSVRKQLAKEICSWPDIAIEPIELDISPTRTHAILQLIGPLRRHWREQHDWCRSSKYGHPTKKEQIAIRQKQERVCQPVKCQRLFPRKMGSQYFAIIDNHDSTDEADSPSLSNAATFWEQANAKFAEFEKKLAEKIAQGHVDEANPWLRRTGWLLYLKPFTFHKLQALIEAPEPPSEDENQSAAIPDTETAEKRTAWAVWSAMGEVGRLSQLSVLHMGVFVRMEAIRSERNQTRYQPLEAYQDANAVTDRVRPWQQILMFFWRTQQQSESQERQSQYRFTRRQKEAWKRLVQIAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>B8LT84</accession>
    <name>B8LT84_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 15">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="5 15">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSTA_070060</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="5 15"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340979.1">
        <property type="nucleotide sequence ID" value="XM_002340938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LT84"/>
    <dbReference type="FunCoup" id="B8LT84">
        <property type="interactions" value="789"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LT84"/>
    <dbReference type="GeneID" id="8108627"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_070060"/>
    <dbReference type="eggNOG" id="KOG0190">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025879_5_0_1"/>
    <dbReference type="InParanoid" id="B8LT84"/>
    <dbReference type="OMA" id="FFGMKKD"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="PhylomeDB" id="B8LT84"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000139">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000154">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000185">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000017">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 15 18" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005124033" description="Protein disulfide-isomerase" evidence="15">
        <location>
            <begin position="21"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="17">
        <location>
            <begin position="5"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="17">
        <location>
            <begin position="339"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="484"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="485"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="54"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="389"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EED23592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="534" mass="57382" checksum="37B3CDBE70FD79BB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTD6</accession>
    <name>B8LTD6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin TrxA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_064800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340402.1">
        <property type="nucleotide sequence ID" value="XM_002340361.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340403.1">
        <property type="nucleotide sequence ID" value="XM_002340362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTD6"/>
    <dbReference type="FunCoup" id="B8LTD6">
        <property type="interactions" value="654"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LTD6"/>
    <dbReference type="GeneID" id="8102407"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_064800"/>
    <dbReference type="eggNOG" id="KOG0907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_14_5_1"/>
    <dbReference type="InParanoid" id="B8LTD6"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="21"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED23015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="155" mass="17103" checksum="CA2535F493EF1930" modified="2009-03-03" version="1">MYLVANSRQKMSLASFIATSTRTARIASSVSARRTFTSTSLNRFRSSLVTMGVKQLKNKSEFDQAISGTDKLVVVDAFAEWCGPCKAIAPKVHSWSEEYTDVEFVKFDVDESPDVAQELGVRAMPTFLFFKNGQKITEVVGVNPPALEAAIKNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTL8</accession>
    <name>B8LTL8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Quinone oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_070230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340997.1">
        <property type="nucleotide sequence ID" value="XM_002340956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTL8"/>
    <dbReference type="STRING" id="441959.B8LTL8"/>
    <dbReference type="GeneID" id="8107315"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_070230"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_1"/>
    <dbReference type="InParanoid" id="B8LTL8"/>
    <dbReference type="OMA" id="WAEVPDP"/>
    <dbReference type="OrthoDB" id="203908at2759"/>
    <dbReference type="PhylomeDB" id="B8LTL8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="14"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED23610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="334" mass="35958" checksum="CF516A5297625DE9" modified="2009-03-03" version="1">MASMKAIGIKGGKGPAEAMFMDTISRPVPTANQALVKIKAFGLNRMDLLQRNGVYPVPPQAPSTMGVEFSGVIEELADSVCDFNVGDEVFGLAYGGAYAEYISVSTRMLVHKPSEISWEEAAGIPETWITATQALNLIGEFKSGQSVLWHAGASSVSISGIQLSKALGATKIFVTAGSQEKIDFCVKELGATAGFNYNTQDWAKGVLEATDGKGVDLIVDFIGANYFASNLAAAARDGRIVELGFMSGGELPAGVNIGPILYKRLRIEGSTLRSREEGYQERLRNLLVENALSKFKDHTFKVFITKVLPFDQIVEAHKLLESNQTKGKIICTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTU9</accession>
    <name>B8LTU9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-rRNA processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_071750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
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        </location>
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            <begin position="750"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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            <dbReference type="Pfam" id="PF26153"/>
        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
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        <source>
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        </source>
    </evidence>
    <sequence length="874" mass="94339" checksum="B234FAA8E39B7D94" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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                <person name="Fedorova-Abrams N.D."/>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
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            <dbReference type="EMBL" id="EED23106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="325" mass="38658" checksum="28BBCD3C1ADBB3F6" modified="2009-03-03" version="1">MEPFSIRIFQQQLHYQQLLLRQNNMRPLESTPLCGQSSRKPNLLCIQCCRRNNAPRTTVSNPLLPEGTPLSFVNKRTENTEIERDYRPRRRTTTELLSICQTIYHETWIMPFILAEHVFNVCGFEWTTNCDEYPGRHLSRERMALYPRQLKNYAITHNTTLHIHPVKGIQIYYRQFDLKRGEYRRLNRAIHIPEQLGPEYVTVSLNFRVCSSSHSLGILSADWVNEIDFPNSVKCVRMDFGKFHDVDRVEEITSKVIENWFFRREESTERPRSEDLFCDVMASYSFFRMKHYVIPTVTWKLTESFNPFVDNYKCPDLDFTNRLPQ</sequence>
</entry>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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        </source>
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        </location>
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            <end position="56"/>
        </location>
    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="66" mass="7394" checksum="DFA0EC10ECB93FF8" modified="2009-03-03" version="1">MDEADNERLGWSGFVEACHKRANRLEDCPTNDNNTARNAGRPNRATELKKLEKEGSAESESESENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVA8</accession>
    <name>B8LVA8_TALSN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">TSTA_066110</name>
    </gene>
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        </lineage>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="PhylomeDB" id="B8LVA8"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED23158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="292" mass="33194" checksum="A5D760E5524AD64B" modified="2009-03-03" version="1">MDTSTAGSITIRFGAGNALQSLGSIDIETPVGNVRFYIIEAMTPFLFSIKDLDRLKVYYDNTKDLLICSEPYLTVPIVRRFGHPFLIWDYSLAIQLHKTLQRVGYDTHPKVIEEINKFCHHCQTHSRLLGRFHFTLQDNIEFNHSIIVDIMYINGKPIDTYLRPLDFIVTDAGKNFISKEFTQLASSVSIMMLISAVECYYAILHRSYEIISEEVPELAPELALQMAVKAVNDTAGPDGYMPTLLVFRVYPRMTEYSPPAPMVAQRAAAVKKAMTEVRRLHTVRQINNALNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVG5</accession>
    <name>B8LVG5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Target of rapamycin complex subunit LST8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_073700</name>
    </gene>
    <organism evidence="7 8">
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        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="interactions" value="610"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LVG5"/>
    <dbReference type="GeneID" id="8105123"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_073700"/>
    <dbReference type="eggNOG" id="KOG0315">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_5_1"/>
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    <dbReference type="OMA" id="VQRNYKH"/>
    <dbReference type="OrthoDB" id="400at2759"/>
    <dbReference type="PhylomeDB" id="B8LVG5"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000923">
        <property type="entry name" value="Protein transport protein (LST8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF0">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
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    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="71"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="112"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="203"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="354"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="247"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="320"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="247"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED23984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="415" mass="45069" checksum="65D4379A8B711821" modified="2009-03-03" version="1">MSVILCTAGYDHTIRFWEALSGICSRTLQHPDSQVNRLCITPDKRYLAAAGHTNVKLFDIKSSNPNPVMTFEGHTNNITGVAFHCEGKWMVTSSEDGTVKVWDTRSGSLQRNYVHKAPVNDVVIHPNQGELISGDRAGTVRVWDLGESVCTHQLIPEDDVAVSSVSVASDGSLLCAGNKRGNVYIWRMIQDTEVTRIVPIAMFQAHRDYLTRVLLSPDVKHLATCSADHTAKIWNLDQAYPPAVAAAAEAAASRPSNTNTTNTNGAATPSPNPPSNGVSSNGVTASPQPQPSRSTSTDQAASDFSMVSSNHNLTLLPSIQNQQQQQQQPNPFPTQPDGPPIDPSTGTPFLETTLSGHQRWVWDCAFSADSAYLVTVSSDHYARLWELASGTIIRQYSGHHRGAVCVALNDYSEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVZ1</accession>
    <name>B8LVZ1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Taf5, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_077240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002341703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVZ1"/>
    <dbReference type="STRING" id="441959.B8LVZ1"/>
    <dbReference type="GeneID" id="8101067"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_077240"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_309764_0_0_1"/>
    <dbReference type="InParanoid" id="B8LVZ1"/>
    <dbReference type="OrthoDB" id="4226663at2759"/>
    <dbReference type="PhylomeDB" id="B8LVZ1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="336"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="760"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="802"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="844"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED24357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="951" mass="107008" checksum="CD677B2EC210409D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>B8LW43</accession>
    <name>B8LW43_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="7 11">3.13.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_074490</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.13.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="10 11">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="EC" id="3.13.2.1" evidence="7 11"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341458.1">
        <property type="nucleotide sequence ID" value="XM_002341417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LW43"/>
    <dbReference type="FunCoup" id="B8LW43">
        <property type="interactions" value="981"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LW43"/>
    <dbReference type="GeneID" id="8102402"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_074490"/>
    <dbReference type="eggNOG" id="KOG1370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025194_2_1_1"/>
    <dbReference type="InParanoid" id="B8LW43"/>
    <dbReference type="OMA" id="YIGVTVE"/>
    <dbReference type="OrthoDB" id="10007170at2759"/>
    <dbReference type="PhylomeDB" id="B8LW43"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1480:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="13">
        <location>
            <begin position="194"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="160"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="225"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="302"/>
            <end position="304"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED24071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="449" mass="48545" checksum="75C93AA98378221A" modified="2009-03-03" version="1">MAAPAHTFKVADISLAAFGRREIELAEVEMPGLMAIRAKYAADQPLAGARIAGCLHMTIQTAVLIETLTALGAEVTWTSCNIFSTQDHAAAAIAASGVPVFAWKGETEEEYEWCLEQQLKAFKDGKKLNLILDDGGDLTSLVHKKYPEQLKDCYGVSEETTTGVHHLYRMLKEGKLLVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALASMGARVIVTEIDPINALQAAVSGFQVTTMEEAAPHGQIFVTTTGCRDILVGRHFEVMKNDAIVCNIGHFDIEIDVAWLKANANSVQNIKPQVDRFLMPNGRHIILLAEGRLVNLGCATGHSSFVMSCSFSNQVLAQIALYKAGDAAFGAKYVEFGNEGKRPVGVYVLPKILDEQVAKLHLEHVNAKLSTLTPVQAEYLGLDAAGPFKSDIYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWG9</accession>
    <name>B8LWG9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LIM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_076480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341667.1">
        <property type="nucleotide sequence ID" value="XM_002341626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWG9"/>
    <dbReference type="STRING" id="441959.B8LWG9"/>
    <dbReference type="GeneID" id="8105950"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_076480"/>
    <dbReference type="eggNOG" id="KOG1703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009967_0_0_1"/>
    <dbReference type="InParanoid" id="B8LWG9"/>
    <dbReference type="OMA" id="CGDPFTP"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="PhylomeDB" id="B8LWG9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000077">
        <property type="entry name" value="LIM domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000127">
        <property type="entry name" value="LIM domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000113">
        <property type="entry name" value="LIM domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF8">
        <property type="entry name" value="PAXILLIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="552"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="631"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="174"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="492"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="412"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED24280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="768" mass="85337" checksum="EE8D892951FA1836" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWP6</accession>
    <name>B8LWP6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vesicle transport v-snare protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_078050</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341830.1">
        <property type="nucleotide sequence ID" value="XM_002341789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWP6"/>
    <dbReference type="FunCoup" id="B8LWP6">
        <property type="interactions" value="862"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LWP6"/>
    <dbReference type="GeneID" id="8105662"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_078050"/>
    <dbReference type="eggNOG" id="KOG1666">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075474_0_0_1"/>
    <dbReference type="InParanoid" id="B8LWP6"/>
    <dbReference type="OMA" id="MEYEAND"/>
    <dbReference type="OrthoDB" id="430637at2759"/>
    <dbReference type="PhylomeDB" id="B8LWP6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007036">
        <property type="term" value="P:vacuolar calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15862">
        <property type="entry name" value="SNARE_Vti1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000002">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.400:FF:000002">
        <property type="entry name" value="Vesicle transport v-SNARE protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="128"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="47"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED24443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="226" mass="25784" checksum="5EF11F02D3796B1C" modified="2009-03-03" version="1">MANPLDTDAGSELFSSYEAELKLVQADLNQKLDQIAETTGEQRKSAIGQAERALDEAIELLDQMRMEKQNIPSAARSKVNIRFRNYSSDIDEVKRKLKSLSDDRRALFGDRYTDDPEAGDAHMEQRQQLLSGTERLERSSARLQESQRLALETEDIGRNTLADLHQQRETIERTRQNLHQSEGYVDTSIKTLRGMARRMATNRIITIAIITVLILLIFAVIFSSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWQ6</accession>
    <name>B8LWQ6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Geranylgeranyl transferase type-2 subunit alpha</fullName>
            <ecNumber evidence="6">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Geranylgeranyl transferase type II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_078160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="6"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341840.1">
        <property type="nucleotide sequence ID" value="XM_002341799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWQ6"/>
    <dbReference type="FunCoup" id="B8LWQ6">
        <property type="interactions" value="102"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LWQ6"/>
    <dbReference type="GeneID" id="8101127"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_078160"/>
    <dbReference type="eggNOG" id="KOG0529">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031996_2_0_1"/>
    <dbReference type="InParanoid" id="B8LWQ6"/>
    <dbReference type="OMA" id="RKFPKCY"/>
    <dbReference type="OrthoDB" id="1658at2759"/>
    <dbReference type="PhylomeDB" id="B8LWQ6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF2">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED24453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="353" mass="41636" checksum="ED19B03CAA5B3282" modified="2009-03-03" version="1">MASHGIPRQSVTTEVDTEQTQKQVRTYRDLERSVHEKIAEHKYTCDTLDQVCELLKKNPEYYTIWNYRRLIRQHDFAQTTSESSGQPDAGEIVPIIKSDLEFLFPLLRSFPKCYWIWNYRLWILNEAKRLLPKQLARQFWEGELALVGKMLNADSRNFHGWGYRTFVIEALEDLADDDKESITQAEIDYTTKMIKTNLSNFSAWHYRTKAIQKLLDEKNASDQERRHVLEQELELSHNALIDPYDQSLWFYHQNLMCVFDPSLADRTLARGLSNSERLRYVQEEKELINEMLEDYTDCKWIYQALVDCNLIAAKIEGTMSAESRAEVLGWLKSLNELDPLRKGHWKDIENQVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWT9</accession>
    <name>B8LWT9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_079280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341959.1">
        <property type="nucleotide sequence ID" value="XM_002341918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWT9"/>
    <dbReference type="STRING" id="441959.B8LWT9"/>
    <dbReference type="GeneID" id="8107601"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_079280"/>
    <dbReference type="HOGENOM" id="CLU_1428871_0_0_1"/>
    <dbReference type="InParanoid" id="B8LWT9"/>
    <dbReference type="OMA" id="MYARYSE"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="PhylomeDB" id="B8LWT9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED24572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="190" mass="22085" checksum="8528E7B740F33BEF" modified="2009-03-03" version="1">MGFKYSRLIDPGEYETQGLCEGIPLRMHKQPQKEDVGTIRCQRDWSRLVKHLKNYKGGLHAKWNFMSTSVPECLPERLEIISYANEFAFLYDDYAEDCDKDQLDTSNDIMQEAFLEGSIKGSISVKRADGMRQMQALILKEMMAIDKERAVTTMKAWVEFLKFAGGRQHDKHFATLEEYIPYRSIDVGKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYG5</accession>
    <name>B8LYG5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_063700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340281.1">
        <property type="nucleotide sequence ID" value="XM_002340240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYG5"/>
    <dbReference type="GeneID" id="8105977"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_063700"/>
    <dbReference type="eggNOG" id="ENOG502SF2G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096170_1_1_1"/>
    <dbReference type="InParanoid" id="B8LYG5"/>
    <dbReference type="OMA" id="HPIARNK"/>
    <dbReference type="OrthoDB" id="5388322at2759"/>
    <dbReference type="PhylomeDB" id="B8LYG5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027911">
        <property type="entry name" value="DUF4604"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15377">
        <property type="entry name" value="DUF4604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4604" evidence="2">
        <location>
            <begin position="6"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED22894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="170" mass="19100" checksum="C604C1DD8F30CE3F" modified="2009-03-03" version="1">MAFNAKNLSYDRNEPAFLRKLRGQYSGDDYARQERSVQRPRKPKDIDDDDAPVYIDEETNEMISKEDYETLVNGTDGKDGGTDKDKEGLEEPTDPAKSKHSEQAASGDTRSQQNLAEIGAQKKRRKAKVISEEEVAKDGSRSKDTSETSKPSTKPSAKRKKIKLSFDEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYI5</accession>
    <name>B8LYI5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_063890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340301.1">
        <property type="nucleotide sequence ID" value="XM_002340260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYI5"/>
    <dbReference type="STRING" id="441959.B8LYI5"/>
    <dbReference type="GeneID" id="8102345"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_063890"/>
    <dbReference type="eggNOG" id="ENOG502S5KQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_721942_0_0_1"/>
    <dbReference type="InParanoid" id="B8LYI5"/>
    <dbReference type="OrthoDB" id="4227237at2759"/>
    <dbReference type="PhylomeDB" id="B8LYI5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF3">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="87"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED22914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="383" mass="43787" checksum="8D2045FA4D434CC4" modified="2009-03-03" version="1">MEVPNIPSGSGKRNTYSLDQDVEFQSKDDKIGTPREDTSRIYNSTLRSRAVFLLTLRRSFPKGRQFLHPMACTDQGHQPKSHYGHHITCIRSCSADELGKAIEIPKHRDNEAGVSYFGKYNENMVFVHEKKNFSPLKDTLTRLTWQLRLSENIKELRILLCLGYTIDLPLPERPSLTQEYIHHVIYAIPGKHVISLRDMLSLTNIHQFQSSLSRTMRFEIAQSLARSILYLHTAEWLHRGTRSSNVLFCSDVDFPDTHQRLSPPYLAGFDYTYLPSDDEIMNAKVQTGFKEWQLYRHPNVLREPTTWLDAALGDNDKAFSKNHDICGLGVILVELGVCKSAARLWKKSSRDKCNGESKCQRYLITELIPEVSSIMGSKNADVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYY6</accession>
    <name>B8LYY6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cinnamoyl-CoA reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_069150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340881.1">
        <property type="nucleotide sequence ID" value="XM_002340840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYY6"/>
    <dbReference type="FunCoup" id="B8LYY6">
        <property type="interactions" value="256"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LYY6"/>
    <dbReference type="GeneID" id="8103924"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_069150"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="InParanoid" id="B8LYY6"/>
    <dbReference type="OMA" id="CEKMQLW"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="PhylomeDB" id="B8LYY6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000191">
        <property type="entry name" value="Methylglyoxal reductase (NADPH-dependent)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED23494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="330" mass="36023" checksum="D8392F4F15E2197F" modified="2009-03-03" version="1">MATVLVTGASGFIAAHVVAAFLRNGYNVRGTVRSEKSAAEVRQTHADYASQLSISIVPDIAAPHAFDEAVKGVNGIIHTASPFVLNANDYEKELFQPAIQGTTSILKAAQEHNPDVRRVVITGSFASVLDPSKGLRPGYVYTEADWNPVTVEEAGTNGSIAYLASKTFAEQAAWKYVKDNKPNFSVTTLLPPMVFGPVVHHVKDVDSLNTSSADIYRLINGSETEVPVNAFWAFVDVRDVAAAHVLAFEKPEAAGQRYLLYTSPYSYQQFCDIIREKFPQLRETTPMGTPGAPIPPVYTLDTSKAVQQLGMKFRPLEETIVDTVESFLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZ62</accession>
    <name>B8LZ62_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF1740-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_083380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRDE2 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478069.1">
        <property type="nucleotide sequence ID" value="XM_002478024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZ62"/>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
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        <location>
            <begin position="1011"/>
            <end position="1037"/>
        </location>
    </feature>
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        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
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        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
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        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
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        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009265"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED21106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1037" mass="118961" checksum="E9D2D8A9981E75E4" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZD1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_089200"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035159_0_0_1"/>
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    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED21684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="570" mass="64260" checksum="E6EBE47466324795" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZG0</accession>
    <name>B8LZG0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_089500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002478631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZG0"/>
    <dbReference type="STRING" id="441959.B8LZG0"/>
    <dbReference type="GeneID" id="8104917"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_089500"/>
    <dbReference type="eggNOG" id="ENOG502SQRZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052827_4_0_1"/>
    <dbReference type="InParanoid" id="B8LZG0"/>
    <dbReference type="OMA" id="DAMAFWI"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="PhylomeDB" id="B8LZG0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF3">
        <property type="entry name" value="THIOESTERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G03960)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="119"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED21713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="232" mass="25755" checksum="3DB65F9141F8FB04" modified="2009-03-03" version="1">MSTKPAALSILQQSLNLQENGDTENSEYVVLNMPARVFKDYTDEDGYFAGTLGTKETIPFLVTLCRRNLEQEVSASLPTQPPPAANDPKSKTPFNPSRPPDTITLVSMSTPGLSGHPRTAHGGVIATLFDEAMSHTIEAHLSLSPKPSTVTRERDAIYTAQLNVRYRKPVYTPGLLVIRTWCIARDARKFWALSNAVQEEQEDDGGQLEWVKRRTISAEASSLWVVTRNEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZM5</accession>
    <name>B8LZM5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_096970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479411.1">
        <property type="nucleotide sequence ID" value="XM_002479366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZM5"/>
    <dbReference type="STRING" id="441959.B8LZM5"/>
    <dbReference type="GeneID" id="8103540"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_096970"/>
    <dbReference type="eggNOG" id="ENOG502SNE1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021599_8_2_1"/>
    <dbReference type="InParanoid" id="B8LZM5"/>
    <dbReference type="OMA" id="GCLLCVQ"/>
    <dbReference type="OrthoDB" id="4314040at2759"/>
    <dbReference type="PhylomeDB" id="B8LZM5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED22448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="446" mass="50005" checksum="6FEEC0848A71A9CE" modified="2009-03-03" version="1">MVGIPLSRGCQPCRRRKVKCDEKRPACLRCTISNLVCPGYPIRLKFIDEGPRFKGNPCTPQSSPEQSLPLSLPGSSSENLSFKLCQTFRPDLPVVKSVATLSKDTFVTELPRHVGLSLACDLAMRALCLAHDTILNPENPVLVQQSRIQYSQALTELQLCVADLERATTMGTICAAMLLSMFELLCADFGASIRHAGGASRLIEASGPHQFKDPFAYRMLHTLQGPIVVECILYRRRCFLDAPLWRDVCRRIQSPFNTLFSRLSRLPNILCALRELESISTGHSRERTSLSDQIVALRNDLQKWRDAPGHAELFCTTTCPSTEFFEFNLNYTSRNAAELLCTYAAMMILLNSALLVLSHSKIPLYKLQNLMLAKQICQSYEYSRVCSPVGSLAMDFAFRVAYVVPDASQKKWIVEKMNEMASPLGGPRHTDVEETELESCFDYLKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZZ0</accession>
    <name>B8LZZ0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_081550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477885.1">
        <property type="nucleotide sequence ID" value="XM_002477840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZZ0"/>
    <dbReference type="GeneID" id="8104793"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_081550"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051551_2_0_1"/>
    <dbReference type="InParanoid" id="B8LZZ0"/>
    <dbReference type="OrthoDB" id="4526357at2759"/>
    <dbReference type="PhylomeDB" id="B8LZZ0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED20922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="186" mass="20489" checksum="806B2E3EC9947180" modified="2009-03-03" version="1">MARNRSEPNKRSLQTALQETTTAATIRAAKGQKIFSPIAIFLDKHRNQTAGLSPHLQRTLAALSDDLATMAQHHFNAYITKPATATQQTKPPMKKSISDAKQSLPDHHLFMCLPPDHAARKMDAYAIFSSLQSQLGINSNALKEVQIIKTGFALCPASMEALSTLKAQKEVISTYFGDCQIEWSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8M086</accession>
    <name>B8M086_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="8">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="8">MTA phosphorylase</shortName>
            <shortName evidence="8">MTAP</shortName>
            <shortName evidence="8">MTAPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_084140</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="8"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478146.1">
        <property type="nucleotide sequence ID" value="XM_002478101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M086"/>
    <dbReference type="STRING" id="441959.B8M086"/>
    <dbReference type="GeneID" id="8101507"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_084140"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3985">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_301910_0_0_1"/>
    <dbReference type="InParanoid" id="B8M086"/>
    <dbReference type="OrthoDB" id="431409at2759"/>
    <dbReference type="PhylomeDB" id="B8M086"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000008">
        <property type="entry name" value="S-methyl-5'-thioadenosine phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="514"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="550"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="112"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="34"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="700"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="748"/>
            <end position="749"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="781"/>
            <end position="782"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="883"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="884"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="906"/>
            <end position="908"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="8">
        <location>
            <position position="865"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="8">
        <location>
            <position position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_03155"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED21183.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="989" mass="108702" checksum="DEF9808096DF36A8" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0I5</accession>
    <name>B8M0I5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_085130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478245.1">
        <property type="nucleotide sequence ID" value="XM_002478200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0I5"/>
    <dbReference type="STRING" id="441959.B8M0I5"/>
    <dbReference type="GeneID" id="8106119"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_085130"/>
    <dbReference type="eggNOG" id="ENOG502QUY7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038374_6_0_1"/>
    <dbReference type="InParanoid" id="B8M0I5"/>
    <dbReference type="OrthoDB" id="5392716at2759"/>
    <dbReference type="PhylomeDB" id="B8M0I5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF5">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="1">
        <location>
            <begin position="14"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase core" evidence="2">
        <location>
            <begin position="166"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED21282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="42491" checksum="5EC233CC5383CA5C" modified="2009-03-03" version="1">MAQLIQTRVGRPSKDLYQFQEEISSRFLDGETMEDIAEYLTNEYQYEINSRTIRRRLKEWGIKRRVRTIDKENLDNQIMILFFQCGLSDDDMHSALQKQGCTIGPRALRVRRRRLGLYRQLSTGDFAALEASIREAVQKELDKGIIESYGREYLFTCFCSKQHIVSRNRTGFSVLRQYLDTLKSERRQPRFIRSDGGDTTLLAAAQHALYKKHNENATISDCYWYGTSTSNQRIEAWWSQLTKSCIFRWWDYFQTLNRDRLFEQDQISDRIAILAVYMPFIRDELYKFIRLWNVHTIRKQKNQPSGVFGKPFFLYHYPEDRDAHVYGLLPDDSLLNGLLETGDWNIDKYVPEETLQWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B8M103</accession>
    <name>B8M103_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 11">Cystathionine beta-synthase</fullName>
            <ecNumber evidence="4 11">4.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_090220</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>L-homocysteine + L-serine = L,L-cystathionine + H2O</text>
            <dbReference type="Rhea" id="RHEA:10112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="4 11"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002478701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M103"/>
    <dbReference type="FunCoup" id="B8M103">
        <property type="interactions" value="911"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M103"/>
    <dbReference type="GeneID" id="8108110"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_090220"/>
    <dbReference type="eggNOG" id="KOG1252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_0_0_1"/>
    <dbReference type="InParanoid" id="B8M103"/>
    <dbReference type="OMA" id="TANSPCE"/>
    <dbReference type="OrthoDB" id="728at2759"/>
    <dbReference type="PhylomeDB" id="B8M103"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007089">
        <property type="term" value="P:traversing start control point of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000003">
        <property type="entry name" value="Cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000118">
        <property type="entry name" value="Related to CYS4-cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005857">
        <property type="entry name" value="Cysta_beta_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01137">
        <property type="entry name" value="cysta_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 10 11" id="KW-0129">CBS domain</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7 11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="369"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED21783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="534" mass="57707" checksum="5CF3B1353A639F9E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8M114</accession>
    <name>B8M114_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_090330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478757.1">
        <property type="nucleotide sequence ID" value="XM_002478712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M114"/>
    <dbReference type="STRING" id="441959.B8M114"/>
    <dbReference type="GeneID" id="8108121"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_090330"/>
    <dbReference type="eggNOG" id="ENOG502SQRM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060131_6_5_1"/>
    <dbReference type="InParanoid" id="B8M114"/>
    <dbReference type="OrthoDB" id="2832510at2759"/>
    <dbReference type="PhylomeDB" id="B8M114"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="92"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED21794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="240" mass="26813" checksum="BB1FF64CFABAEB2B" modified="2009-03-03" version="1">MTQTKPEITVVRATENDTLVLAEIESLAFDGPSPYALNRTNTTSENEPDKGSEPISQNRIMFGLPSAEGRAIRARGINERLKTSSDYHIYKAVLEEEDGKEKIVGFAAWRFCADEPFPVEDTWKDLPWEGCANPRACNDFFGAIARFRTKYLGGKKVALLETLVIHPSAQGLGIGSKMLERGLEDAKNLGLTESWLEASDAGHGLYYKFGFRVVEEYITDFFKYGAEGSSRLRVMKREDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1G1</accession>
    <name>B8M1G1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS allantoate transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_090970</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478820.1">
        <property type="nucleotide sequence ID" value="XM_002478775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1G1"/>
    <dbReference type="FunCoup" id="B8M1G1">
        <property type="interactions" value="160"/>
    </dbReference>
    <dbReference type="GeneID" id="8101587"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_090970"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="InParanoid" id="B8M1G1"/>
    <dbReference type="OMA" id="QYQWLGS"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="PhylomeDB" id="B8M1G1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000245">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF1">
        <property type="entry name" value="ALLANTOATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="57"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED21857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="505" mass="56519" checksum="4441227F16B3F446" modified="2009-03-03" version="1">MDEKQATVSDRHVDERILKHSHDADEALQAIQQIDGQVIEIDAETNKRLLRIIDWHLMPLMCVVYGMNYLDKTTISYASIMGMQKDLRLKGNDYQWLGSMFYFGYLGWEYPASQLLQRMPLGKYSAICVVLWGMVLACFAAVSNFGGAVTIRLFLGICEASVTPGFALLTSQWYTRKEQGQRTGLWFSFNGFGQIVGGLVAYGIAKGTDKYGSSIAPWKIVFLATGLFTIVIGLAFLWVVPDNQLNARWLSEEDRVLAVERVRINQQGIGNKHFKMYQFKEAMMDPMTWAFAFYALVADIPNGGLTNFFSQLIENFGYTAEQSLLYGCPGGAVEVIALISSGFLGDWLGRRLLCSMGGLVSAMVGMILIIALPLSNNDGRLIGYYMTQASPTPFVALLSMISSNVAGYTKKTTVAAIYLISYCVGNIIGPQTFRPKDKPRYVPAEITIVVCYGVCLIDIAFIWWWYSKENKKKAMIRASEGYAKMENQEWLDLTDGENAEFVYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1U0</accession>
    <name>B8M1U0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_085490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478281.1">
        <property type="nucleotide sequence ID" value="XM_002478236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1U0"/>
    <dbReference type="GeneID" id="8104514"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_085490"/>
    <dbReference type="HOGENOM" id="CLU_763283_0_0_1"/>
    <dbReference type="InParanoid" id="B8M1U0"/>
    <dbReference type="PhylomeDB" id="B8M1U0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="363" mass="40398" checksum="9AF287FD84F6D408" modified="2009-03-03" version="1">MAEDTRQCSSCLVGKPINQFKSKTGKRLWKTKQDHRASKRKSNEPAATDPPAEETHIPHFIWPTAASLRRIAPQDLTAQPIQHQIQEMQEAQQPSPTPSQSSTSQTPSTPDPLTAMSAGISLTPDPLAFVGNEPVSPTLRRTTTGLSLLSSIIDPPATFSSLATSTLDPLAILSSGASTPVIRTAPAHFTLLPYKARRSKRLSSLCLTLRHPIMLNHFVCTICQTPRYFSWRIANGVNICEYCQNLSIPFEEQHKSCVSYQQDVPIAAFFDDKSNEHAHYNLCRASSIIYAETDLSYVPESSNVHFDDTPIVVSTLAQEYSEQDPPYIPGNRDALLQPALIETDFNYIKNFHKSLDKQQLEYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8M278</accession>
    <name>B8M278_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_087780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478505.1">
        <property type="nucleotide sequence ID" value="XM_002478460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M278"/>
    <dbReference type="GeneID" id="8100907"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_087780"/>
    <dbReference type="HOGENOM" id="CLU_783415_0_0_1"/>
    <dbReference type="InParanoid" id="B8M278"/>
    <dbReference type="OrthoDB" id="4227259at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
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        <location>
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            <end position="152"/>
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    </feature>
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            <end position="247"/>
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            <end position="25"/>
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    </feature>
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            <begin position="51"/>
            <end position="65"/>
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    </feature>
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            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="354" mass="38750" checksum="C59FFDCF9BB869DB" modified="2009-03-03" version="1">MHIVSAREEKLTRKEEIIKERDSKKQIILAEEDAMTQSQQSRGDEEDEDMHETASEGTKVEESTRHNSPTSTPPPQTATYSFNSIPNSPSAADILRPLSTVAAQRSFPLPTSGTLALLARGHHADGRRISQDFDESTSHTTSSGGLGSSSLTHDRLLQSDSAMDATTTATDRDDVRVSSAEAAAAAVRGFTALVWESPSRRMETPTTTESKPIRSVSAYSSSSPLSSPTPSLAEGSSDPVEEEEEDGDIRHHIFQSPFASIFPEGTNTITPLIIRRYDDINNNDNSNNTIDDAADADHRTIFKYKGPKMEERRGRGVCLSIDEVYPKMQCNASFRRGTWLALDPRVGVTSPLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2P1</accession>
    <name>B8M2P1_TALSN</name>
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        <submittedName>
            <fullName evidence="6">Differentiation regulator (Nrd1), putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">TSTA_091940</name>
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    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <dbReference type="NCBI Taxonomy" id="441959"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002478870.1"/>
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    <dbReference type="STRING" id="441959.B8M2P1"/>
    <dbReference type="GeneID" id="8109508"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_091940"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_017390_0_0_1"/>
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    <dbReference type="OrthoDB" id="6407164at2759"/>
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    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="RRM1_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RRM3_MRN1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Differentiation 1 negative regulator"/>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA-BINDING PROTEIN MRN1"/>
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    <dbReference type="Pfam" id="PF10378">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="192"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="283"/>
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        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="508"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        <location>
            <begin position="31"/>
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        <location>
            <begin position="109"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="580"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="721"/>
            <end position="800"/>
        </location>
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        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="586"/>
            <end position="598"/>
        </location>
    </feature>
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        <location>
            <begin position="613"/>
            <end position="623"/>
        </location>
    </feature>
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        <location>
            <begin position="633"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="721"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="742"/>
            <end position="753"/>
        </location>
    </feature>
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        <location>
            <begin position="788"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED21952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="831" mass="88655" checksum="46039176D332E9D6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2X8</accession>
    <name>B8M2X8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cell division cycle protein Cdc20, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_094790</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479196.1">
        <property type="nucleotide sequence ID" value="XM_002479151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2X8"/>
    <dbReference type="FunCoup" id="B8M2X8">
        <property type="interactions" value="147"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M2X8"/>
    <dbReference type="GeneID" id="8103809"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_094790"/>
    <dbReference type="eggNOG" id="KOG0305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014831_6_0_1"/>
    <dbReference type="InParanoid" id="B8M2X8"/>
    <dbReference type="OMA" id="PVKSHHG"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="PhylomeDB" id="B8M2X8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000098">
        <property type="entry name" value="WD repeat-containing protein slp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="9">
        <location>
            <begin position="287"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="332"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="415"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="546"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="78"/>
            <end position="136"/>
        </location>
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        <location>
            <begin position="590"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED22233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="609" mass="65591" checksum="40926BE2153F55F3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8M315</accession>
    <name>B8M315_TALSN</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_092330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478954.1">
        <property type="nucleotide sequence ID" value="XM_002478909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M315"/>
    <dbReference type="STRING" id="441959.B8M315"/>
    <dbReference type="GeneID" id="8099415"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_092330"/>
    <dbReference type="HOGENOM" id="CLU_1027140_0_0_1"/>
    <dbReference type="InParanoid" id="B8M315"/>
    <dbReference type="OMA" id="WMALAIM"/>
    <dbReference type="OrthoDB" id="4227144at2759"/>
    <dbReference type="PhylomeDB" id="B8M315"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877517" evidence="2">
        <location>
            <begin position="21"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED21991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="218" mass="22408" checksum="9D7651454B1EA420" modified="2009-03-03" version="1">MTTLIRFSLVFLTLFGTIQAEQMLAFAPVTALARWDGLAPRQLFGDCPASTQTLCPDKLGCCPKGVACTYSRSIPVCEESCKGGPTCPQGGCCQVGYICGTTNNFCTPAPTAPPKKVDNKEEAVEAPVTSAPSTTPTGATEDADEHEETTSRPSTPTVRASSSHHVVSATKTATATTARDGSKYVGVPSGSNTKSPSQSAQATNSGASSHASSLSIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8M372</accession>
    <name>B8M372_TALSN</name>
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        <submittedName>
            <fullName evidence="14">ABC transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_092940</name>
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    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="EED22048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479011.1">
        <property type="nucleotide sequence ID" value="XM_002478966.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M372"/>
    <dbReference type="GeneID" id="8099472"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_092940"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="InParanoid" id="B8M372"/>
    <dbReference type="OMA" id="RNFGFIC"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="PhylomeDB" id="B8M372"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002416">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="741"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1169"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1239"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1285"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1310"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1343"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1436"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="131"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="833"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="788"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1470"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="437"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="805"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED22048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1497" mass="168164" checksum="48305CDDDC30301C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3L1</accession>
    <name>B8M3L1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hexose carrier protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_096320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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        <property type="protein sequence ID" value="EED22383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479346.1">
        <property type="nucleotide sequence ID" value="XM_002479301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3L1"/>
    <dbReference type="GeneID" id="8103475"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_096320"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="InParanoid" id="B8M3L1"/>
    <dbReference type="OMA" id="TFCCSIG"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="PhylomeDB" id="B8M3L1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="18"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED22383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="516" mass="56952" checksum="D56452F018BAE925" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8M404</accession>
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        <submittedName>
            <fullName evidence="10">Rad4 family protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="10" type="ORF">TSTA_039460</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
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        <property type="protein sequence ID" value="EED20747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002481136.1"/>
    </dbReference>
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    <dbReference type="STRING" id="441959.B8M404"/>
    <dbReference type="GeneID" id="8109284"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_039460"/>
    <dbReference type="eggNOG" id="KOG2179">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_003639_0_2_1"/>
    <dbReference type="InParanoid" id="B8M404"/>
    <dbReference type="OMA" id="TWPGKTK"/>
    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="PhylomeDB" id="B8M404"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="Rad4_BHD3_sf"/>
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    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF03835">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="547"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="606"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="676"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="189"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="355"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="794"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="373"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="828"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="849"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED20747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="914" mass="102840" checksum="1662D10F60A884C4" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8M445</accession>
    <name>B8M445_TALSN</name>
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        <recommendedName>
            <fullName evidence="5">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_039820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481222.1">
        <property type="nucleotide sequence ID" value="XM_002481177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M445"/>
    <dbReference type="STRING" id="441959.B8M445"/>
    <dbReference type="GeneID" id="8109319"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_039820"/>
    <dbReference type="eggNOG" id="ENOG502SNFF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_811765_0_0_1"/>
    <dbReference type="InParanoid" id="B8M445"/>
    <dbReference type="OrthoDB" id="160645at2759"/>
    <dbReference type="PhylomeDB" id="B8M445"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054293">
        <property type="entry name" value="DUF7029"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055647">
        <property type="entry name" value="DUF7223"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22974">
        <property type="entry name" value="DUF7029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23865">
        <property type="entry name" value="DUF7223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7029" evidence="1">
        <location>
            <begin position="75"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7223" evidence="2">
        <location>
            <begin position="219"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED20788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="37472" checksum="8867D509393816B4" modified="2009-03-03" version="1">MAPTYSHLQLSWLIVSFFGYLSYSLKLQPITLTSASLAAGSLHSTSLALRNNESFLWSSTIGDSTTLATLTLHTPDDGESIISLERLQGLTTSIKCSNDTIALQLNDASAYVQLRNQWDWMNQAENNTVILVTGAGQCDWNEDRQPFSISSFSYSNNNTELVLSGSRVEWREIASNYHLHMSTMAQTALSRRDYTGDYTLDFNHQLGFGNWSFPIDPTFSVGLTCKTCYTTGDFAFEFDLKTELGIPVDATLTIAPRNVSVVLDPTFSLSGNIGSSLSFKETFLRIPIDGIAVAGIIDLGPEIAFTGSLNIGPLKGTASVTARHASVEDQLRCISIFFAIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4H6</accession>
    <name>B8M4H6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_024930</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479605.1">
        <property type="nucleotide sequence ID" value="XM_002479560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4H6"/>
    <dbReference type="FunCoup" id="B8M4H6">
        <property type="interactions" value="601"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M4H6"/>
    <dbReference type="GeneID" id="8106710"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_024930"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002833_1_0_1"/>
    <dbReference type="InParanoid" id="B8M4H6"/>
    <dbReference type="OMA" id="WMGNFTA"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="PhylomeDB" id="B8M4H6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000005">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000075">
        <property type="entry name" value="Sporulation-specific chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877537" description="chitinase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="13">
        <location>
            <begin position="34"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED19171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="425" mass="46934" checksum="5226AD8D4AD733DE" modified="2009-03-03" version="1">MPIFTKILLALVGFLSLAKASPVSLDMEKRDGSYRSVAYYVDWAIYGRNFHPQNLTSMLPSLTHILYSFANIHPDTGEVYLSDTYADIQKHYSADSWNDSGNDVYGCIKQLYLLKKVNRNLKVLLSIGGWTYSANFVGATGSEANRANFVKSAVGFVRDLGLDGIDIDWEYPNNSAEADNFVALLKELRASLDNYAAENSPGYHYLISASVPAGPSNYEKLHIRDMNQYLDMWNLMAYDYSGSWDEIAGMDANLYTSSAYLNSTPYNTDQAIIYYIGNGATPSNINLGIPLYGRSFTNTDGPGKPFSGVGDGSWENGLWDYKALPQEGAKLYQDDSSVSAWSYDSSQRLMISYDTPDIVKAKADYIKSKGLGGGMYWESSGDKTGSESLVNTLVNALGGTDALQHVDNELNYPASVYDNMRNGMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4Z4</accession>
    <name>B8M4Z4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ARID/BRIGHT domain protein (SWI1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_027260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479863.1">
        <property type="nucleotide sequence ID" value="XM_002479818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4Z4"/>
    <dbReference type="STRING" id="441959.B8M4Z4"/>
    <dbReference type="GeneID" id="8109645"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_027260"/>
    <dbReference type="eggNOG" id="KOG2744">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008900_0_0_1"/>
    <dbReference type="InParanoid" id="B8M4Z4"/>
    <dbReference type="OMA" id="NPIVCGR"/>
    <dbReference type="OrthoDB" id="1938591at2759"/>
    <dbReference type="PhylomeDB" id="B8M4Z4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16871">
        <property type="entry name" value="ARID_Swi1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051232">
        <property type="entry name" value="ARID/SWI1_ChromRemod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964:SF27">
        <property type="entry name" value="HAT-TRICK, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964">
        <property type="entry name" value="RBP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="5">
        <location>
            <begin position="291"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="437"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="891"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="106"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="439"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED19429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="982" mass="107112" checksum="4C9C1135E6D2A208" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8M576</accession>
    <name>B8M576_TALSN</name>
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        <recommendedName>
            <fullName evidence="4">Antigenic cell wall galactomannoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_029570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480116.1">
        <property type="nucleotide sequence ID" value="XM_002480071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M576"/>
    <dbReference type="GeneID" id="8106524"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_029570"/>
    <dbReference type="eggNOG" id="ENOG502RNR6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1696672_0_0_1"/>
    <dbReference type="InParanoid" id="B8M576"/>
    <dbReference type="OrthoDB" id="3438016at2759"/>
    <dbReference type="PhylomeDB" id="B8M576"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877296" description="Antigenic cell wall galactomannoprotein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="16302" checksum="192D012383E22913" modified="2009-03-03" version="1">MFLLRMLRFFIFLPLLTSTVTLAQSTGTSTGLTISPSALSDIENLITGAKTLLSPDSIGNIETTLTGAATLLSGTTANDTKTLLTEVSALLSPDLVLAVSKLVTADTVNKLGDIVDNAHTLLSAEFVNQTTTLINDVTPLVDDLSKVLGGLLSALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8M577</accession>
    <name>B8M577_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_029580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED19683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002480072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M577"/>
    <dbReference type="STRING" id="441959.B8M577"/>
    <dbReference type="GeneID" id="8106525"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_029580"/>
    <dbReference type="eggNOG" id="ENOG502SKT5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059206_3_1_1"/>
    <dbReference type="InParanoid" id="B8M577"/>
    <dbReference type="OMA" id="RYWQESL"/>
    <dbReference type="OrthoDB" id="4444391at2759"/>
    <dbReference type="PhylomeDB" id="B8M577"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36151">
        <property type="entry name" value="BLR2777 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36151:SF3">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="1">
        <location>
            <begin position="52"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="327" mass="37429" checksum="6A703C2384318340" modified="2009-03-03" version="1">MIVIQHAVRNMTLPDYSAQSNSDFVRLTGSLDSHSETEILQSLDKLQQAPKILQEGILLTGGAVAILLQAAAHGMARTASKTGTDGQVKTLAEQLYQSIHLTAVYLYGLTFGTHQQRKQILNRIYAFQAQQQQQQRRISHAARNGISHLSPYPQDPRLRLWIAATLYATGTEVYQRIVHELSFKEAELAFNEFSVLFNLILNLPKGLWPTNRAAFWAYWDEYVEKLDVDTRARPVVRDLERIHNVPSWVRLSMPFMKNITPEMLPPHVREQYGFQSSPMSRFMYRASMGISRAIYAVLPRVIRSIPKRRVMKEVKDMLREPQSVAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5S6</accession>
    <name>B8M5S6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_033010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480487.1">
        <property type="nucleotide sequence ID" value="XM_002480442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5S6"/>
    <dbReference type="STRING" id="441959.B8M5S6"/>
    <dbReference type="GeneID" id="8105040"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_033010"/>
    <dbReference type="eggNOG" id="ENOG502QR2H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009768_0_0_1"/>
    <dbReference type="InParanoid" id="B8M5S6"/>
    <dbReference type="OMA" id="HQNMLFL"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="PhylomeDB" id="B8M5S6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF27">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="58"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="211"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="792"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="801"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="813"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED20053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1018" mass="113104" checksum="A3D6DDE70CDC357F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7L2</accession>
    <name>B8M7L2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hemolysin-III channel protein Izh2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_028520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479999.1">
        <property type="nucleotide sequence ID" value="XM_002479954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7L2"/>
    <dbReference type="FunCoup" id="B8M7L2">
        <property type="interactions" value="335"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M7L2"/>
    <dbReference type="GeneID" id="8108368"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_028520"/>
    <dbReference type="eggNOG" id="KOG0748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8M7L2"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="PhylomeDB" id="B8M7L2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED19565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="321" mass="36068" checksum="7B28AC0E035DEC9E" modified="2009-03-03" version="1">MSDPRLRSLTRKRQPIVDSKSPANENITPEMVVKQPAKAIRKLLHWDELPPWLQDNHYIHSGYRPASSSFLVSFHSLTYLHNETVNIYSHLLPALVALPAGIRLYQVLAPRYQSATQADISAFACFFVGATFCLGMSAIYHTISNHSPSVARIGNALDYVGIVGLITGSFIPSVYYGFYCALSLQCIYWTMISTIGVGCIFVCLLPRFRTPEWRPFRAMMFVSMGLSAIFPVIHGLWLYGPKQMIDQIGLYWLLLQGFLYILGATIYAARVPERLLPGRFNIFGSSHQIFHVLVVCAAVSHLTGLLRAFDYRHSGLAELCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7S5</accession>
    <name>B8M7S5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_030690</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480238.1">
        <property type="nucleotide sequence ID" value="XM_002480193.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M7S5"/>
    <dbReference type="GeneID" id="8101748"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_030690"/>
    <dbReference type="eggNOG" id="KOG1870">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001060_9_0_1"/>
    <dbReference type="InParanoid" id="B8M7S5"/>
    <dbReference type="OMA" id="KPRGCTG"/>
    <dbReference type="OrthoDB" id="289314at2759"/>
    <dbReference type="PhylomeDB" id="B8M7S5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF24">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUSP" evidence="10">
        <location>
            <begin position="309"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="666"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="265"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="642"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1036"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1129"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1454"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1549"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1038"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1073"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1087"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1146"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1475"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1490"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1556"/>
            <end position="1569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED19804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1638" mass="180392" checksum="8DAB038F75307CEC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8M891</accession>
    <name>B8M891_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glutamyl-tRNA synthetase, cytoplasmic, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_036300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480838.1">
        <property type="nucleotide sequence ID" value="XM_002480793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M891"/>
    <dbReference type="STRING" id="441959.B8M891"/>
    <dbReference type="GeneID" id="8101901"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_036300"/>
    <dbReference type="eggNOG" id="KOG1148">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1397169_0_0_1"/>
    <dbReference type="InParanoid" id="B8M891"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="PhylomeDB" id="B8M891"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="8">
        <location>
            <begin position="72"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED20404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="195" mass="22399" checksum="0E9EB87038879557" modified="2009-03-03" version="1">MTNMSDVTSRQREPLEDNNQQAKAEAPSGLETNPQTNPKESVTQPMESIFTSGFLAEVYKEKPLGSAGVDRIVTRFPPEPNGFLYLGYSKAIVVNFGFAEHHGGDCYLCYDDTNPAKEEEKYFTAIEEIRAVDDIRLGRYYSTGYRRRIRYSLFFPRRIRISNIIRLLVMPADTISAIPRRYSNYPPYIQSYGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8P0</accession>
    <name>B8M8P0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_037710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480987.1">
        <property type="nucleotide sequence ID" value="XM_002480942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8P0"/>
    <dbReference type="GeneID" id="8102147"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_037710"/>
    <dbReference type="HOGENOM" id="CLU_051551_2_1_1"/>
    <dbReference type="InParanoid" id="B8M8P0"/>
    <dbReference type="OMA" id="FDQYCES"/>
    <dbReference type="OrthoDB" id="4526357at2759"/>
    <dbReference type="PhylomeDB" id="B8M8P0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED20553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="96" mass="9929" checksum="0F464A430F6B441B" modified="2009-03-03" version="1" fragment="single">MARKGPGTDGPLQTALLESTSAATTRASEGQKIFSPIAAFLDKHRSQTTGLAPHLLRALTALSDDLASVAQRHFSAYISGISTTSILPALSPSPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8M923</accession>
    <name>B8M923_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_111540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481310.1">
        <property type="nucleotide sequence ID" value="XM_002481265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M923"/>
    <dbReference type="STRING" id="441959.B8M923"/>
    <dbReference type="GeneID" id="8098809"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_111540"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_3_0_1"/>
    <dbReference type="InParanoid" id="B8M923"/>
    <dbReference type="OMA" id="MHRPANE"/>
    <dbReference type="OrthoDB" id="4357294at2759"/>
    <dbReference type="PhylomeDB" id="B8M923"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="218" mass="23520" checksum="E2FEECF975CB2194" modified="2009-03-03" version="1">MTASLLTLDVKGAFDAVLPSRLIRRLREQGWPTNLVLWIASFATGRSVQIRLDGEIGPSIDIACGLPQGSPVSGILFMLYIAPLFCLGNPRNRFGYADDAANLAISTSLATNCEALSDSLQEALNWGAAEGITFAPDKYELLHFSRHKADQDLTCTPSHVSETASKALTVANALRSLGNTICGVKPHLLQQAVSACVLHKVYYGVETWWPGCTRPGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9J3</accession>
    <name>B8M9J3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isopenicillin N-CoA epimerase, putative</fullName>
            <ecNumber evidence="2">5.1.99.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_117700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.4" evidence="2"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481987.1">
        <property type="nucleotide sequence ID" value="XM_002481942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9J3"/>
    <dbReference type="STRING" id="441959.B8M9J3"/>
    <dbReference type="GeneID" id="8105828"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_117700"/>
    <dbReference type="eggNOG" id="KOG3957">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033975_5_0_1"/>
    <dbReference type="InParanoid" id="B8M9J3"/>
    <dbReference type="OMA" id="VVIDPFR"/>
    <dbReference type="OrthoDB" id="16747at2759"/>
    <dbReference type="PhylomeDB" id="B8M9J3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008111">
        <property type="term" value="F:alpha-methylacyl-CoA racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050509">
        <property type="entry name" value="CoA-transferase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228:SF5">
        <property type="entry name" value="ALPHA-METHYLACYL-COA RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228">
        <property type="entry name" value="SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="383" mass="41562" checksum="18EDD7147A8FC327" modified="2009-03-03" version="1">MWSSHPLHGVKVVELAGLAPGPFAGLLLADYGASVLRVDRPPNTSVAPAGDHLTRHKSSICMDLKDARSRELLLSILLRADVLIDPFRPGVLERLGLSPTEVLLKHNPRLIIARMTGFRRAGKYKDMAGHDINYLAVSGVLSMLGRSGEPPLAPGNLLGDFAGGGAMCFLGILLALISRSATGKGQVVEANMVDGAAYLATMPRLARKTPVWSEPRGQNLLDGGCPYYDTYETKDKGKYFAVGALEPHFYAALLKGLGFAKNDVPASEDRDNWPAIRQIFTKRFKEKTRAEWEAIFDGTDACATPVLEQSELEENGYQQRLPVALVSTPGKTFKADEAGWEGGGLLPGDGGEMRLKEWFGWTKGKEYLEQDGILGSIKALSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9P9</accession>
    <name>B8M9P9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved fungal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_118210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482043.1">
        <property type="nucleotide sequence ID" value="XM_002481998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9P9"/>
    <dbReference type="STRING" id="441959.B8M9P9"/>
    <dbReference type="GeneID" id="8099745"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_118210"/>
    <dbReference type="eggNOG" id="ENOG502QR4F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026445_0_0_1"/>
    <dbReference type="InParanoid" id="B8M9P9"/>
    <dbReference type="OMA" id="VPMFTAD"/>
    <dbReference type="OrthoDB" id="2153176at2759"/>
    <dbReference type="PhylomeDB" id="B8M9P9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012469">
        <property type="entry name" value="DUF1688"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687:SF3">
        <property type="entry name" value="PROTEIN URG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07958">
        <property type="entry name" value="DUF1688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="500" mass="54932" checksum="D0C2F63BC008986F" modified="2009-03-03" version="1">MGLFKRKDSKHSIHSEEEQDSLSAHSTRNSTASLRSSAVKSSGNLPVSIPEVPISKPPDPNLDPAAYLRSIHAVRERSKIVLQKARADKLNHFDVDMSKFEATASYVVSIIKRDYSPDYSSIPPHGRWQHFDVGGRPRIDQLLQSWPSTIDPTERTRRLIDLFLVSVLLDAGAGNKWSYKSKESGKVFSRSEGLAVASLEMFKTGLFSSDPTEPCQVDGAGLKKVTVEALAKGMQHSEQNPLAGIEGRAGLLVRLSEALNNQDLFGVDARPGNMLDYLLSHPTTLASSVPIVSVPTLWSVLMDGLAAIWPPSRTQIDGVSIGDAWTCKALPQTPPAKPWEAIAPFHKLTQWLCYSIMVPMTRLMKIHFAGAELLTGLPEYRNGGLLIDLGLLTLKEPDVQRGLVTYKENSRKEGQPSMEVVPMFSADDDVIVEWRAVTVGFLDDLLEEVNHQLGLRGDDALSLAQLLEAGTWKGGREIAEVSRPNTKEPPIMIISDGTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9U0</accession>
    <name>B8M9U0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_118590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482084.1">
        <property type="nucleotide sequence ID" value="XM_002482039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9U0"/>
    <dbReference type="STRING" id="441959.B8M9U0"/>
    <dbReference type="GeneID" id="8099783"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_118590"/>
    <dbReference type="eggNOG" id="KOG0533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052367_4_0_1"/>
    <dbReference type="InParanoid" id="B8M9U0"/>
    <dbReference type="OMA" id="RNDYPRD"/>
    <dbReference type="OrthoDB" id="5382468at2759"/>
    <dbReference type="PhylomeDB" id="B8M9U0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12418">
        <property type="entry name" value="RRM_Aly_REF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF82">
        <property type="entry name" value="THO COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="82"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="150"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED18092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="330" mass="36570" checksum="2BFF1C6A60C65C52" modified="2009-03-03" version="1">MDRSLEEIISERPAKQQNRRGRGSGNNSNAPRDGVKKSYRDRVDLDRDWVHDRFDDIGDSRSSRRDNRSRRDRESPDSDQPARLRIDNLHWDLTEADLEGLFSKIGPVQRVRINFDRAGRSEGTATVTYQYVEDARQAIREFDGANARGQPIRLTLLPGGGGRGGPKTEKSKSLFDRIERPHDRTERSLSPDEEGATGGGRRRRGGRGRAAGAPGRRSDTSKPAPDHIDRYIPGRQQSPSRRNATGRRPGERRDDRRNNRRNANGGSGPRPKKTQEELDAEMDDYWGNTTAATGTTTEENTVAAPATVAATGETGGAASAGNDDDIDMIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9U9</accession>
    <name>B8M9U9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA/RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_118670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482093.1">
        <property type="nucleotide sequence ID" value="XM_002482048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9U9"/>
    <dbReference type="STRING" id="441959.B8M9U9"/>
    <dbReference type="GeneID" id="8099791"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_118670"/>
    <dbReference type="eggNOG" id="ENOG502QQKF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010014_4_1_1"/>
    <dbReference type="InParanoid" id="B8M9U9"/>
    <dbReference type="OMA" id="GFFICAC"/>
    <dbReference type="OrthoDB" id="2017974at2759"/>
    <dbReference type="PhylomeDB" id="B8M9U9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000202">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.7, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF0">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN EST1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA-binding" evidence="2">
        <location>
            <begin position="275"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED18101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="661" mass="74925" checksum="6ED8D12AFDD38AA5" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAE0</accession>
    <name>B8MAE0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_123710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482634.1">
        <property type="nucleotide sequence ID" value="XM_002482589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAE0"/>
    <dbReference type="GeneID" id="8108282"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_123710"/>
    <dbReference type="HOGENOM" id="CLU_1769345_0_0_1"/>
    <dbReference type="InParanoid" id="B8MAE0"/>
    <dbReference type="OrthoDB" id="4226619at2759"/>
    <dbReference type="PhylomeDB" id="B8MAE0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="147" mass="15971" checksum="F30EF877F10C07DB" modified="2009-03-03" version="1">MSSKQKLNPLKRKASRELPPNTNRNDNTQMVAATTQADTKIHKVSSLYQQTYLETIAEIKSLLQHYAATIAADEHVNATNNSTVAGNGGTGAAAADARAELKAILDDLAQKPELVELDEVKTILKDCGIEICIHMEGGRKIADVWMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAF9</accession>
    <name>B8MAF9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pogo transposable element, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_123890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482653.1">
        <property type="nucleotide sequence ID" value="XM_002482608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAF9"/>
    <dbReference type="GeneID" id="8098341"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_123890"/>
    <dbReference type="eggNOG" id="KOG3105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_4_0_1"/>
    <dbReference type="InParanoid" id="B8MAF9"/>
    <dbReference type="OrthoDB" id="3790270at2759"/>
    <dbReference type="PhylomeDB" id="B8MAF9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="60"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED18661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="559" mass="63960" checksum="FA3BF3AC1EDF9472" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MB00</accession>
    <name>B8MB00_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Developmental regulator VelB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_124280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the velvet family. VelB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482693.1">
        <property type="nucleotide sequence ID" value="XM_002482648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MB00"/>
    <dbReference type="STRING" id="441959.B8MB00"/>
    <dbReference type="GeneID" id="8098379"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_124280"/>
    <dbReference type="eggNOG" id="ENOG502S1B4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022491_0_0_1"/>
    <dbReference type="InParanoid" id="B8MB00"/>
    <dbReference type="OMA" id="YQDGRSW"/>
    <dbReference type="OrthoDB" id="1746739at2759"/>
    <dbReference type="PhylomeDB" id="B8MB00"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF3">
        <property type="entry name" value="VELVET COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="8">
        <location>
            <begin position="51"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED18701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="357" mass="38501" checksum="DAC7E6D873D1FCB3" modified="2009-03-03" version="1">MYTAVEHDRSQPIPHQPPPLSMDRIAPPGGPVYPTSVTVAPLRSTEHLKPVSTIHGGRIWSLHVVQQPIRARMCGFGDKDRRPITPPPCIRLIVKDANTDKEIDINEIDTSFYVLTVDLWNAEGTSEVNLVRHSANSPSISTATSSSYPPPQESNISPTYPSFAGQHGYPQQSLGYHQQVPGYYGQNSMYQNPYAAAPPQGGPYYGGGYYQGGMQAPNLSPQSAAPGGMFTRNLIGSLSASAFRLTDPDNKIGVWFILQDLSVRTEGTFRLKMNFVNVGTSQSPGASGAPVLNHGSAPVLASVFSEPFQVFSAKKFPGVIESTPLSKCFALQGIKIPIRKDGVKGRGVGGEGDDEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MB92</accession>
    <name>B8MB92_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_125930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482873.1">
        <property type="nucleotide sequence ID" value="XM_002482828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MB92"/>
    <dbReference type="STRING" id="441959.B8MB92"/>
    <dbReference type="GeneID" id="8098104"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_125930"/>
    <dbReference type="eggNOG" id="ENOG502QQN3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_4_3_1"/>
    <dbReference type="InParanoid" id="B8MB92"/>
    <dbReference type="OMA" id="MDSYKIA"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="PhylomeDB" id="B8MB92"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="20"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Glutathione S-transferase UstS-like C-terminal" evidence="2">
        <location>
            <begin position="111"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED18881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="244" mass="28195" checksum="2F015632B52177B2" modified="2009-03-03" version="1">MASHTYILFDIPTKAPQVCWSMNTWRTRLLLNYKGLDYKTEWLEYPNIGVRLGHHVPPNEQGPHFTLPAIQLPDGSYVMDSYKIADIIEERHLEPRVHRLNIPAQLTFRNILTNLMRQLTPLYIPGIAQRLLSNESIDFFIAARQKDVGMPLDEYGKQHGPGAFDRAEPFLHEMTALLDETAGPYFLGDTVSYTDFIWAAILLFFKCFGDDIYGELLMRSGNSQVHTEFLDALSQWTKRNDYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8MB95</accession>
    <name>B8MB95_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Galactose oxidase, putative</fullName>
            <ecNumber evidence="5">1.1.3.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_125960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.3.9" evidence="5"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482876.1">
        <property type="nucleotide sequence ID" value="XM_002482831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MB95"/>
    <dbReference type="STRING" id="441959.B8MB95"/>
    <dbReference type="GeneID" id="8098108"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_125960"/>
    <dbReference type="eggNOG" id="ENOG502SCD5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013444_1_0_1"/>
    <dbReference type="InParanoid" id="B8MB95"/>
    <dbReference type="OMA" id="DSHAWLW"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="PhylomeDB" id="B8MB95"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045480">
        <property type="term" value="F:galactose oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF68">
        <property type="entry name" value="GALACTOSE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002874934" evidence="2">
        <location>
            <begin position="20"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Glyoxal oxidase N-terminal" evidence="3">
        <location>
            <begin position="274"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose oxidase-like Early set" evidence="4">
        <location>
            <begin position="388"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED18884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="491" mass="53022" checksum="006BBF3FF2838EC5" modified="2009-03-03" version="1">MNLFQAFIVAFGLVVGCVSYEHSPSNATHPWSERIDFPLIPVAVSMIPQTGDLVIWSAYKNESFGVDASGVTQTAIYNLTNGTVAHYSVDHTEHDMFCPGISLDFKGRIIVSGGDTEEKTSIFDGESWKPAADMKIPRGYQASTTITDGRIFTIGGSFSGGIGGKDGEIYDLEADEWTLLPGCSAEPMLTKDAGGLYRSDNHAWLFAWSNGSVLQAGPSPRMHWFDTRGNGSMTFAGTRANDSDAMTGMAVIIATSNAHLITVRKPGEPVNVEALDNMHSARAFANAVILPDGKVFIVGGQSHPIVFTDENASMIPEMWDPKTKKFTELPELPTPRNYHSSALLLPNATVFVGGGGLCPWKCDANHLDAHIYTPPYLFESDGVTPATRPIISHVANPILKVGQTINVTLSKPVESNQKLTFSMVRMASSTHTVNTDQRRVNVSPQAATSTLFTLGLPRDPGVLLPGYWHLFAMLNGVPSEAETILVEPPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBF9</accession>
    <name>B8MBF9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Integral membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSTA_116130</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481815.1">
        <property type="nucleotide sequence ID" value="XM_002481770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBF9"/>
    <dbReference type="STRING" id="441959.B8MBF9"/>
    <dbReference type="GeneID" id="8099640"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_116130"/>
    <dbReference type="eggNOG" id="ENOG502SM6F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_6_2_1"/>
    <dbReference type="InParanoid" id="B8MBF9"/>
    <dbReference type="OMA" id="DYVEMGY"/>
    <dbReference type="OrthoDB" id="2496787at2759"/>
    <dbReference type="PhylomeDB" id="B8MBF9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF160">
        <property type="entry name" value="SAT4 FAMILY MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="14" id="KW-0349">Heme</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877405" evidence="16">
        <location>
            <begin position="20"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="17">
        <location>
            <begin position="8"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="36"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="40"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="59"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EED17823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="427" mass="47155" checksum="28E6EE94CE6D9BC9" modified="2009-03-03" version="1">MRSFAITAIFAVISTVVIATAPPPSETALLGELPPCGLACLEQEIPKSNCTATDLPCICTNKELNGLIALCVSQSCTIRESLTTKNVTSTLCGAPVRDRTSIVSNAGIIGGVVAVFFYILRMLSRVPQFGGGTLGLDDAVMTLVVALAIALAALSDVLAKHGLGKDMWTVPFDDITYILYIYYFDEDIYLSILPLTKISILLFYLRVFPQRYFRNAAYVAIALNVGYWIAFVLVSVFQCRPINAAWLRWDGEHPAKCQNINAQGWTSAVLNMALDILTMVLPLHELRKLTMSMRKKILVMIMFSLGIFVTLVSILRLHTLVEFSNTSNLTWDYVELGYWSTIEVDVGIICACLPAIRKLLWKIFPNTLGSAVRRGAKTPNYYEQRSGHSGGMIRENRRATLEDGDAFPLVEVTTLVEVTSHTELPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBU6</accession>
    <name>B8MBU6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_119840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482221.1">
        <property type="nucleotide sequence ID" value="XM_002482176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBU6"/>
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        <property type="interactions" value="354"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MBU6"/>
    <dbReference type="GeneID" id="8105259"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119840"/>
    <dbReference type="eggNOG" id="KOG1725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028431_2_1_1"/>
    <dbReference type="InParanoid" id="B8MBU6"/>
    <dbReference type="OMA" id="DTQYWVV"/>
    <dbReference type="OrthoDB" id="10009287at2759"/>
    <dbReference type="PhylomeDB" id="B8MBU6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED18229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="169" mass="19231" checksum="34CAC84F12C5F1DA" modified="2009-03-03" version="1">MASFQDRAQHQIAQLDKELSKYPLLNNLERQTSVPKVYAILGVVGIYFFLVFFNIAGEFLVNFAGFLIPGYYSLNALFTAGTADDTQWLTYWVVYAFLTVIESAINASYWFPFYYIFKFVLVLWMSLPQFNGAQVVFHSFIQPLFARFFSSGSTSSNLKAQAEAASKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCS1</accession>
    <name>B8MCS1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_126810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482965.1">
        <property type="nucleotide sequence ID" value="XM_002482920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCS1"/>
    <dbReference type="GeneID" id="8099108"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_126810"/>
    <dbReference type="HOGENOM" id="CLU_1448641_0_0_1"/>
    <dbReference type="InParanoid" id="B8MCS1"/>
    <dbReference type="OrthoDB" id="4226811at2759"/>
    <dbReference type="PhylomeDB" id="B8MCS1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="187" mass="20951" checksum="2A9FD6FA1706D1D9" modified="2009-03-03" version="1">MGPKRGKKGTPWPEPRFADDPDIRAYVAAAIKDLEALKKHQEALEIGMPRELSTTVVDTFLHLARRVKNTPTNEQLAQPLAKVELHVEKTQKEVSQASREITTTKSNTNRLVEAICHPTFPGVYGYEAGYAPTDLLNKMVGDPIAEKIDRFNKNQVADEELEDLASVLISSLEDYITEDADEYDDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCU6</accession>
    <name>B8MCU6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_127060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482990.1">
        <property type="nucleotide sequence ID" value="XM_002482945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCU6"/>
    <dbReference type="GeneID" id="8099133"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_127060"/>
    <dbReference type="HOGENOM" id="CLU_2063042_0_0_1"/>
    <dbReference type="InParanoid" id="B8MCU6"/>
    <dbReference type="PhylomeDB" id="B8MCU6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="119" mass="13914" checksum="C1B9600A9119B2FD" modified="2009-03-03" version="1">MFWCISKFDIKVEDNREDIDIPLEDRQQKDEAQEAEFQDIVPNPISNYEESDSEENDSEENNGEEGNTLPQPSKHALRKRRIILVEKHTDDKALPGTGDQASRRVWAWLGRKDDGFDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8MD79</accession>
    <name>B8MD79_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine/threonine protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_114170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481595.1">
        <property type="nucleotide sequence ID" value="XM_002481550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MD79"/>
    <dbReference type="FunCoup" id="B8MD79">
        <property type="interactions" value="234"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MD79"/>
    <dbReference type="GeneID" id="8109179"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_114170"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8MD79"/>
    <dbReference type="OMA" id="RIECCSP"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="B8MD79"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
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        <location>
            <begin position="305"/>
            <end position="604"/>
        </location>
    </feature>
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        <location>
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        </location>
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        </location>
    </feature>
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            <begin position="79"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED17603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="658" mass="73492" checksum="C9A5CFC1282A1EEC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8ME39</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_012250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Trichocomaceae</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="PhylomeDB" id="B8ME39"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF4">
        <property type="entry name" value="FLUG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED16116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="153" mass="19085" checksum="29DA0932DC5A3436" modified="2009-03-03" version="1">MAPPPLPPANPEEHQFWTDPIICEETRARLEYFRSLGWFPPQNYKPKTLEGIAIVERYWRKYCIRSKEEYINYLLLEDKAIYMNFFDWMYKTSRKKLLQSYDEYWRRHLCQYFSLFARRRMNGDVHDQMRRFLDKEFPAERKISRRMKKKKHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEB0</accession>
    <name>B8MEB0_TALSN</name>
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        <submittedName>
            <fullName evidence="4">GAJ protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_016160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED16537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002483726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEB0"/>
    <dbReference type="STRING" id="441959.B8MEB0"/>
    <dbReference type="GeneID" id="8106389"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_016160"/>
    <dbReference type="eggNOG" id="KOG3433">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044486_0_0_1"/>
    <dbReference type="InParanoid" id="B8MEB0"/>
    <dbReference type="OMA" id="WEDNISI"/>
    <dbReference type="OrthoDB" id="9978204at2759"/>
    <dbReference type="PhylomeDB" id="B8MEB0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040453">
        <property type="entry name" value="Mnd1_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022793">
        <property type="entry name" value="Rrn10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28054">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28054:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03962">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="330"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="396"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED16537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="538" mass="61041" checksum="0D43BEF4AA8A0AED" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEJ0</accession>
    <name>B8MEJ0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MYND domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_016920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483851.1">
        <property type="nucleotide sequence ID" value="XM_002483806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEJ0"/>
    <dbReference type="STRING" id="441959.B8MEJ0"/>
    <dbReference type="GeneID" id="8103665"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_016920"/>
    <dbReference type="HOGENOM" id="CLU_2110591_0_0_1"/>
    <dbReference type="InParanoid" id="B8MEJ0"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="PhylomeDB" id="B8MEJ0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="15"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED16617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="115" mass="12631" checksum="C8E9A60989275626" modified="2009-03-03" version="1">MASKNSIKFDITEICAGCKKSSTSLSQPLKCCARCKETLYCSRECQTADWKTHKKSCNKAPRPSLSGNMIDSERSGLDDFTYYNTVAHTIPGARELAKTLNISLPTGDNCREGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFF7</accession>
    <name>B8MFF7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Restriction of telomere capping protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_017650</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RTC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483925.1">
        <property type="nucleotide sequence ID" value="XM_002483880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFF7"/>
    <dbReference type="STRING" id="441959.B8MFF7"/>
    <dbReference type="GeneID" id="8109022"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_017650"/>
    <dbReference type="eggNOG" id="ENOG502SEU0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034020_0_0_1"/>
    <dbReference type="InParanoid" id="B8MFF7"/>
    <dbReference type="OMA" id="ETISCGY"/>
    <dbReference type="OrthoDB" id="128308at2759"/>
    <dbReference type="PhylomeDB" id="B8MFF7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039024">
        <property type="entry name" value="RTC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028094">
        <property type="entry name" value="RTC4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391:SF1">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14474">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01312">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Restriction of telomere capping protein 4 C-terminal" evidence="9">
        <location>
            <begin position="331"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="68"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED16691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="473" mass="53208" checksum="8829D701FF7DD7C6" modified="2009-03-03" version="1">MSTASRRVGQSRRNHTAGPPLTQVGGKPIVRGSSNDDMLKEKKNQSQKPEPATDDEPLSSSEEESEKEESKEREEEENHQRESEVAKEVRQEGAAKRKRDEGKNNNPPSSSQADDKDAWFDRISSQRSRNSSSQAKYGEFKMPRDFDAEKGSDAFLSPRNIDVPPTPRKAQKRTNGSTANSSKNKEEIAFRMPAAFEEDLYDRLSSPVNQFKDPPGQSLTSVPSSAFTAREFDLDFDDDLSSLSSPPSSLSEDDKTPSKSLCPNCNAPVDSDLLGEYLVQPHRRLRDDRLFCESHKVNKAEKEWTNNKYPTIDWDTFDQRVRDHLPEFERLLVPNPTTFFRGRFESTLKDGQAKVFKMSLEDDSVERLSCGYYGPKGASKMLNYVTSKYSGKLRQLAATDKVIKAAGAAAYAQAVLVPELTVLLIKKDMNVDSQDARQILRTSTDIGNRLNPADNDQIHVNEDDENNHDNNYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFN8</accession>
    <name>B8MFN8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_020850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484262.1">
        <property type="nucleotide sequence ID" value="XM_002484217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFN8"/>
    <dbReference type="STRING" id="441959.B8MFN8"/>
    <dbReference type="GeneID" id="8109346"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_020850"/>
    <dbReference type="HOGENOM" id="CLU_622838_0_0_1"/>
    <dbReference type="InParanoid" id="B8MFN8"/>
    <dbReference type="OMA" id="FHEYDLR"/>
    <dbReference type="OrthoDB" id="4360040at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="440" mass="49565" checksum="5986568E3007122E" modified="2009-03-03" version="1">MDVEICLKFSDNREVSLNVQDSLTGAQLVERIKSETGGQKIILTCMGARLPFDKTLRDLDVRPGYVFKVDMDSAHQVIEIRQKAATIPKTAKFNRGYIIEQICRLAESQIATPLDLAKFLLGDSNKVYRVAGEAGKDEILSIFNLEEAAIPLRLTDDTLHHSTPDDILKNFRALEDAGYDRNNEQYCRLRAEFVMIPALVQARRNANVPLRSSTRGAPKKKHAISMTPTTQMRRDTDAEAPRRDLKMFHEYDLRAEINHPVSGIPHVFTGRADWAAGHSGRGFSDSVLVCVEAKKKETFGNAELQLTAYLAICYHERKKANKSVPSVQGFSTDGQRYTFQLLTSDGTLYSSKTYDTVDEKDLEIVYNFIVHQVQTAINLSPTSTPVKGSRTEKEEAAKTYAQDTFWGIFEPPPYCSDGEEEERPELDLDTFALRERGMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFW2</accession>
    <name>B8MFW2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_009510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483063.1">
        <property type="nucleotide sequence ID" value="XM_002483018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFW2"/>
    <dbReference type="GeneID" id="8102747"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_009510"/>
    <dbReference type="HOGENOM" id="CLU_1705425_0_0_1"/>
    <dbReference type="InParanoid" id="B8MFW2"/>
    <dbReference type="PhylomeDB" id="B8MFW2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED15829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="154" mass="17119" checksum="B62FC11045E1973F" modified="2009-03-03" version="1">MPQAVITSTMKSLNGFMITLETTHIKELRIANDAYMVPSIEEEDEGIHKELPSSKTLSQLIQDHVQLPLESIQDVSRFTPLTGANAIPVGIPDSAKVKISETPILSTSTTSTSARMLDPYIKLPPEEYRREPIDSQLAMKFAKAWDKSKNYSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHF6</accession>
    <name>B8MHF6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_021920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484369.1">
        <property type="nucleotide sequence ID" value="XM_002484324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHF6"/>
    <dbReference type="GeneID" id="8098458"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_021920"/>
    <dbReference type="eggNOG" id="ENOG502RXQJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030671_1_0_1"/>
    <dbReference type="InParanoid" id="B8MHF6"/>
    <dbReference type="OMA" id="SLKHFAH"/>
    <dbReference type="OrthoDB" id="5396at2759"/>
    <dbReference type="PhylomeDB" id="B8MHF6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF10">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="38505" checksum="4628318A02287873" modified="2009-03-03" version="1">MATDNERKFEFPAFDDLPSIDGAPKGCLWGFYDRDGVKDEVGSINLLTPTVVQAAASSEIRTGRHIQLDWPLHSLSYPGFGRKEFEHKVISLHDGLDIYGFDDELHINTQSGSQWDGLKHHASQEHAVFYNGLKFDDALKTDANGIHNWCNRGGIVGRGILVDIRAANWSSDIKPRYYEYKKKVLPSGFSRYEIPVQDIQDALAYQGTKPRQADILLVRTGFIREHNAASDEERLTATRKVGRTIGVKACEETVRWLYSQHFAGLVGDTVAFEAWPPEKDNQWVLHEWALTWWGTPIGEMWDLEALAVECERQNRWSFFVTSAPLRVQGGIASPPCAIAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHG3</accession>
    <name>B8MHG3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_021990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484376.1">
        <property type="nucleotide sequence ID" value="XM_002484331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHG3"/>
    <dbReference type="GeneID" id="8098465"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_021990"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_11_2_1"/>
    <dbReference type="InParanoid" id="B8MHG3"/>
    <dbReference type="OMA" id="NIGHAPD"/>
    <dbReference type="OrthoDB" id="4526357at2759"/>
    <dbReference type="PhylomeDB" id="B8MHG3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="560"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="732" mass="80207" checksum="0D46F63210327633" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHM8</accession>
    <name>B8MHM8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C6 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_011180</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483243.1">
        <property type="nucleotide sequence ID" value="XM_002483198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHM8"/>
    <dbReference type="STRING" id="441959.B8MHM8"/>
    <dbReference type="GeneID" id="8109891"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_011180"/>
    <dbReference type="eggNOG" id="ENOG502QVF9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009617_1_0_1"/>
    <dbReference type="InParanoid" id="B8MHM8"/>
    <dbReference type="OMA" id="PSHFIGN"/>
    <dbReference type="OrthoDB" id="2283631at2759"/>
    <dbReference type="PhylomeDB" id="B8MHM8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF79">
        <property type="entry name" value="C6 FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="659"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="661"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED16009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="844" mass="95897" checksum="5DB6A5A5BED13ACC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MI52</accession>
    <name>B8MI52_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_022680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484448.1">
        <property type="nucleotide sequence ID" value="XM_002484403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MI52"/>
    <dbReference type="FunCoup" id="B8MI52">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MI52"/>
    <dbReference type="GeneID" id="8107105"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_022680"/>
    <dbReference type="eggNOG" id="KOG1337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041939_3_1_1"/>
    <dbReference type="InParanoid" id="B8MI52"/>
    <dbReference type="OMA" id="WNDAIGM"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="PhylomeDB" id="B8MI52"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF137">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="17"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="409" mass="47420" checksum="2C85158CAABC8522" modified="2009-03-03" version="1">MSLGEEHVAFIRWCESQGIKIHGVSPAGIPGRRLGMIATRRISAGETIVTVPLVAMLTIDSVPPSFVRMFSKATPLHAILAAFFTHGDPVLLEKWEYWRRVWPLRHDFEKSLPLFWSEMLPANESILPPSVSGSWSFRNKKPEDIEYGSRYTNILSHQKKRLQDAWSEVLLVFPHTDWNFFSYNWLILNTRSFFYVSPEKDEPEDWNDAIALVPFADYFNHDDKAPCEVNFNGEYYTFKASRRFEKGEELFISYGSHSNDFLLVEYGFLLDDNKSDAIFLDDIVLPELATANKKELLSRQLYGDYKVTSSGFCNRTKAAACMKYMTNDQWRDYILGRSQGVENRTASVLHDWIGAYLKKSMTSIKILEDMQLRPRSESQYWEKDRIDILLRRWNQIRVLCVEASKAISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIN3</accession>
    <name>B8MIN3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_045820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>propanoyl-CoA + oxaloacetate + H2O = (2S,3S)-2-methylcitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23780"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58853"/>
            <dbReference type="EC" id="2.3.3.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485078.1">
        <property type="nucleotide sequence ID" value="XM_002485033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIN3"/>
    <dbReference type="FunCoup" id="B8MIN3">
        <property type="interactions" value="1010"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MIN3"/>
    <dbReference type="GeneID" id="8107569"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_045820"/>
    <dbReference type="eggNOG" id="KOG2617">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022049_2_1_1"/>
    <dbReference type="InParanoid" id="B8MIN3"/>
    <dbReference type="OMA" id="VLEWLFK"/>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="PhylomeDB" id="B8MIN3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050440">
        <property type="term" value="F:2-methylcitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06105">
        <property type="entry name" value="ScCit1-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010109">
        <property type="entry name" value="Citrate_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01793">
        <property type="entry name" value="cit_synth_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF8">
        <property type="entry name" value="CITRATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR610109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED15125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="473" mass="52022" checksum="9D7975DC294A9F72" modified="2009-03-03" version="1">MAFSLRLGSSAFRSTLVSKPAVQTAAFNGVRCYSAGKAKSLKETFAEKLPGEIEKVKKLRKEYGSKVVGEVTLDQVYGGARGIKSLVWEGSVLDSEEGIRFRGRTIPECQEVLPKAPGGEEPLPEGLFWLLLTGEVPSEQQVRDLSAEWAARSDVPKFVEELIDRCPNDLHPMAQFSLAVTALEHESSFAKAYAKGLNKKEYWQYTFEDSMDLIAKLPTIAARIYRNVFKDGKVAAVQKDKDYAFNLANQLGFGDNKDFVELMRLYLTIHSDHEGGNVSAHTTHLVGSALSSPYLSLAAGLNGLAGPLHGLANQEVLVWLQKMKKAIGNDLSDEAIKGYLWSTLNAGQVVPGYGHAVLRKTDPRYVSQREFALRHLPDDPMFKLVSQVYKIAPGVLTEHGKTKNPYPNVDAHSGVLLQYYGLTEANYYTVLFGVSRALGVLPQLIIDRALGAPIERPKSFSTEAYAKLVGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJA1</accession>
    <name>B8MJA1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_041680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484643.1">
        <property type="nucleotide sequence ID" value="XM_002484598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJA1"/>
    <dbReference type="STRING" id="441959.B8MJA1"/>
    <dbReference type="GeneID" id="8102945"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_041680"/>
    <dbReference type="eggNOG" id="KOG0159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_4_1"/>
    <dbReference type="InParanoid" id="B8MJA1"/>
    <dbReference type="OMA" id="SWHTLEK"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="PhylomeDB" id="B8MJA1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED14690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="419" mass="47301" checksum="EB1567E57B9FE0BB" modified="2009-03-03" version="1">MSNRLDKSAYFYCMLGNPKASFGTIAADLHRIRRGALNPFFSQQAVAKFSGHVQAIVDRFVDRIKSCAERGETIPLFYAYRCVTVDIITEYIFGHQFNLLDRADWGRDFYSAWRSLWELSPTIRQFPWMMDAFMAMPRWFTALTNPKALEVVDLFSDVDEQTKILLSSDLKQIESKPYPIVVWGLSKSDLLPASEKTFTRLAVEANGLLAAGFETTGAVLTHTTYHILANPEVHRKLLAELAEAIPDLDHIPGFQQLEQLSYLRAVVKEGLRLAVGAYSRLPRVNPSGDMQYGNWVIPAGTAIGMSALFIAKSPLLFPDPDTFNPERWIINDQSPGSERLEQYILAFGKGTRSCVGTNLAHAEMYTILATIFRKFPHIKLHNTTPRDVELAHDYFAGMTRADTQGLQVIVDRTNRSEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MK84</accession>
    <name>B8MK84_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_046910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485192.1">
        <property type="nucleotide sequence ID" value="XM_002485147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MK84"/>
    <dbReference type="STRING" id="441959.B8MK84"/>
    <dbReference type="ESTHER" id="talsn-b8mk84">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="8108055"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_046910"/>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_17_1_1"/>
    <dbReference type="InParanoid" id="B8MK84"/>
    <dbReference type="OMA" id="RIMLGEC"/>
    <dbReference type="OrthoDB" id="6846267at2759"/>
    <dbReference type="PhylomeDB" id="B8MK84"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="16"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED15239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="532" mass="60090" checksum="5DB83272E10B1807" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B8MK85</accession>
    <name>B8MK85_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18 19">Pyruvate carboxylase</fullName>
            <ecNumber evidence="6 19">6.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">TSTA_046920</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="function">
        <text evidence="3">Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 19">
            <text>hydrogencarbonate + pyruvate + ATP = oxaloacetate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 19">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.4.1.1" evidence="6 19"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485193.1">
        <property type="nucleotide sequence ID" value="XM_002485148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MK85"/>
    <dbReference type="FunCoup" id="B8MK85">
        <property type="interactions" value="717"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MK85"/>
    <dbReference type="GeneID" id="8108056"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_046920"/>
    <dbReference type="eggNOG" id="KOG0369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_1_1_1"/>
    <dbReference type="InParanoid" id="B8MK85"/>
    <dbReference type="OMA" id="AEACICY"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="PhylomeDB" id="B8MK85"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07937">
        <property type="entry name" value="DRE_TIM_PC_TC_5S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000018">
        <property type="entry name" value="Biotin carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.600.10:FF:000002">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000033">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000012">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.600.10">
        <property type="entry name" value="pyruvate carboxylase f1077a mutant domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055268">
        <property type="entry name" value="PCB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005930">
        <property type="entry name" value="Pyruv_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006761">
        <property type="entry name" value="PRK09282.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009554">
        <property type="entry name" value="PRK12999.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01235">
        <property type="entry name" value="pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778">
        <property type="entry name" value="PYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778:SF2">
        <property type="entry name" value="PYRUVATE CARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001594">
        <property type="entry name" value="Pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 19 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 19" id="KW-0092">Biotin</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9 19 28" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11 19 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16 28" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="26">
        <location>
            <begin position="40"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="25">
        <location>
            <begin position="162"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="27">
        <location>
            <begin position="578"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="24">
        <location>
            <begin position="1115"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="active site" evidence="20">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="587"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="659"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="22">
        <location>
            <position position="755"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="785"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="787"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="920"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="23">
        <location>
            <position position="755"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-biotinyllysine" evidence="23">
        <location>
            <position position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00072910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR001594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="EED15240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1191" mass="130809" checksum="E3E65A808130E0F6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKA2</accession>
    <name>B8MKA2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CAAX prenyl protease</fullName>
            <ecNumber evidence="15">3.4.24.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSTA_047080</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Proteolytically removes the C-terminal three residues of farnesylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.24.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 15">Belongs to the peptidase M48A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="15"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485210.1">
        <property type="nucleotide sequence ID" value="XM_002485165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKA2"/>
    <dbReference type="FunCoup" id="B8MKA2">
        <property type="interactions" value="858"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MKA2"/>
    <dbReference type="GeneID" id="8098501"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_047080"/>
    <dbReference type="eggNOG" id="KOG2719">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025947_3_3_1"/>
    <dbReference type="InParanoid" id="B8MKA2"/>
    <dbReference type="OMA" id="FVIEEKF"/>
    <dbReference type="OrthoDB" id="360839at2759"/>
    <dbReference type="PhylomeDB" id="B8MKA2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.10:FF:000002">
        <property type="entry name" value="CAAX prenyl protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 15 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 15 19" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 14 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 1 N-terminal" evidence="18">
        <location>
            <begin position="42"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="17">
        <location>
            <begin position="230"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EED15257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="456" mass="52062" checksum="8B186917DA8438F3" modified="2009-03-03" version="1">MINNLLQALARFLDRPLFPWKTVLVGFSLGQYVFESFLSLRQYRVLQRTKPPKVLEGEITNKVFEDSQTYGRAKAKFGFFSGIYGQLQNLVFIYYDFLPKIWALTGVCLVRYFPAWSQGEIGHTLLFFFAFNILTTILSLPISYYSTFVLEEKFGFNKQTVGLWITDMLKGQALGIVLGGPIMAAVLKIIQKTGNEFFYYLWIFSILVQVFAITIYPIVILPMFNKLSPLEAGPIKTGVEELAQKLKFPLHDIYSIDGSKRSAHSNAYFFGFPWKKHIVIYDTLMEKSEPEEVVAVLSHELGHWKLGHTTKLFTIAQAHMFYIFALFTAFVNNKSLFQSFGFHNEQPIMIGFLLFSDALAPMDAVVKFLMNILSRKFEFEADAFAANLGQSKLLAQSLLKLQIQNLSTMDADWMYASYHYSHPILTERLAALGWKGKGSEKSEDSEKPVKAADREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKD6</accession>
    <name>B8MKD6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">14-3-3 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_047400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485244.1">
        <property type="nucleotide sequence ID" value="XM_002485199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKD6"/>
    <dbReference type="STRING" id="441959.B8MKD6"/>
    <dbReference type="GeneID" id="8099290"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_047400"/>
    <dbReference type="eggNOG" id="KOG0841">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058290_0_0_1"/>
    <dbReference type="InParanoid" id="B8MKD6"/>
    <dbReference type="OMA" id="SKGTDKH"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="PhylomeDB" id="B8MKD6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000001">
        <property type="entry name" value="14-3-3 gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="4">
        <location>
            <begin position="18"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="241"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED15291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="285" mass="31847" checksum="E93799753230D4AC" modified="2009-03-03" version="1">MTADVSELLNRRVADILKSKTFLARLCEQAERYDEMVTYMKLNGELSVDERNLLSVAYKNVVGTRRASWRIISSIEQKEESKGSSEHVSIIRDYRQKIETELEKVCQDVLNVLDESLIPKAESGESKVFYHKMKGDYHRYLAEFASGNKRKVAATAAHEAYKNATDVAQTELTPTHPIRLGLALNFSVFYYEILNSPDRACHLAKQAFDDAIAELDSLSEESYRDSTLIMQLLRDNLTLWTSSDGGEPEAVEAKEDKPVEGEAAAPAEEKPAEEEAPAAAPAPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLJ8</accession>
    <name>B8MLJ8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Adenylosuccinate lyase</fullName>
            <shortName evidence="12">ASL</shortName>
            <ecNumber evidence="6 12">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_049690</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = fumarate + AMP</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="6 12"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485484.1">
        <property type="nucleotide sequence ID" value="XM_002485439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLJ8"/>
    <dbReference type="FunCoup" id="B8MLJ8">
        <property type="interactions" value="731"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MLJ8"/>
    <dbReference type="GeneID" id="8102129"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_049690"/>
    <dbReference type="eggNOG" id="KOG2700">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030949_1_1_1"/>
    <dbReference type="InParanoid" id="B8MLJ8"/>
    <dbReference type="OMA" id="VQENAMK"/>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="PhylomeDB" id="B8MLJ8"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03302">
        <property type="entry name" value="Adenylsuccinate_lyase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.60:FF:000001">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000005">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF1">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenylosuccinate lyase C-terminal" evidence="13">
        <location>
            <begin position="374"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED15531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="482" mass="54300" checksum="C2CF9C4BEC49A249" modified="2009-03-03" version="1">MASNNDVYQTPLNSRYSSNEMKYLFSPRNRFSTWRSLWLWLAEAEKELGLPISDEAISQMKAHLIIQDDEFAVAAEEEKRRRHDVMAHVKAFGDVAPAASGMIHVGATSCFVTDNADLIFLRDGLDILIPKLATVIDKLAAFAKEYKDLPCLGFTHGQPAQLVTVGKRAALWLQDLLMDLRNLERARKDLRFRGVKGTTGTQASFLQIFNGDHAKVEKLDELVTQKAGFESAFIISGQTYSRKIDVDVANALGSFGSTCERIGGDIRHLAMLKEVEEPFEKDQIGSSAMAYKRNPMRSERLCSLGRHLQNLPKDALDTYSAQWFERSLDDSAIRRISLPELYLCADACLILLNNVTSGFVVYPEVIRRRVQEELPFMATENIIMACVAKGLSRQDAHEEIRVLSHQASDNVKKQGKSNDLIDRIRRTEFFAPIIPQLDSLLDPATFIGRAPQQVEKFVATEVEEVLRPYREKLVVDVAELHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLP4</accession>
    <name>B8MLP4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase subgroup catalytic core protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_101470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486145.1">
        <property type="nucleotide sequence ID" value="XM_002486100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLP4"/>
    <dbReference type="STRING" id="441959.B8MLP4"/>
    <dbReference type="GeneID" id="8101835"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_101470"/>
    <dbReference type="eggNOG" id="ENOG502RG5A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022442_0_0_1"/>
    <dbReference type="InParanoid" id="B8MLP4"/>
    <dbReference type="OMA" id="DMRWTYM"/>
    <dbReference type="OrthoDB" id="2338662at2759"/>
    <dbReference type="PhylomeDB" id="B8MLP4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877807" description="Glycoside hydrolase subgroup catalytic core protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="574" mass="63735" checksum="C26889A0798D2FEB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLS8</accession>
    <name>B8MLS8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_100400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486033.1">
        <property type="nucleotide sequence ID" value="XM_002485988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLS8"/>
    <dbReference type="STRING" id="441959.B8MLS8"/>
    <dbReference type="GeneID" id="8097924"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_100400"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2575469_0_0_1"/>
    <dbReference type="InParanoid" id="B8MLS8"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="PhylomeDB" id="B8MLS8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED13795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="81" mass="8865" checksum="BBBCB282F30AB3F3" modified="2009-03-03" version="1">MQKISKTTVNGVAPGGTVTDMFHAVSHHYIPNGEKFLAEERQQMAAHASPLHRNGFPEDVARVVGFLVSKEGDSLESKYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MM15</accession>
    <name>B8MM15_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_097830</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485765.1">
        <property type="nucleotide sequence ID" value="XM_002485720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MM15"/>
    <dbReference type="STRING" id="441959.B8MM15"/>
    <dbReference type="GeneID" id="8108422"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_097830"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_4_1"/>
    <dbReference type="InParanoid" id="B8MM15"/>
    <dbReference type="OMA" id="WCELYIA"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="PhylomeDB" id="B8MM15"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED13527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="505" mass="56272" checksum="FF763F357169A4DB" modified="2009-03-03" version="1">MLDSGELDIASLCWLIPSGIAVYWVYIAVFNIFWHPLAAFPGPPIAAISTLYKAYIDLVSKSSFVHTLEKLHAQYGDVVRVGPNEIHFQSPSAYLEIYNVSNRWDKEETLYHSFGEDRSSFGFLTYDEAKERKNALSRLFSQKAIADAQALVLEKVVQLCDSFEELGPRPADLFYAYRCMSVDVITYLCFGNTVNAIEAPGYEAPIIKAMDASLPVFVGFKHSSLLKGAIMNCPPNVSKVVSPATSGLVDLQQILKAQIKDLSKNPERLRNLPHSTTIYHELLRPEAYSSKTVPSADSLYEESQALLFGGADTTGTTLMHGSFYVLTAPTVYRRLKEELISAWPVLEDAPDLCELQKLPYLTAVLKESLRMSPGVASPLPRVVPASGARIGKVFVPGGTIVEMSGHFVHRNEAIFPNPHGFIPDRWLGDEGKDLDKWLVAFSKGPRSCLGINLAWAELYLCFAYVFRKFELEIDPSSPKELKWRDCFLPEYHGPHLKARLTKVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MM36</accession>
    <name>B8MM36_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dipeptidyl-peptidase V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_098040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485786.1">
        <property type="nucleotide sequence ID" value="XM_002485741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MM36"/>
    <dbReference type="STRING" id="441959.B8MM36"/>
    <dbReference type="GeneID" id="8108443"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_098040"/>
    <dbReference type="eggNOG" id="KOG2100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008615_2_0_1"/>
    <dbReference type="InParanoid" id="B8MM36"/>
    <dbReference type="OMA" id="NDYAGKE"/>
    <dbReference type="OrthoDB" id="43744at2759"/>
    <dbReference type="PhylomeDB" id="B8MM36"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF27">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE FAMILY MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="4">
        <location>
            <begin position="406"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED13548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="620" mass="68852" checksum="1A1DAD8C668FCA04" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMK1</accession>
    <name>B8MMK1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldo/keto reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_100010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485993.1">
        <property type="nucleotide sequence ID" value="XM_002485948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMK1"/>
    <dbReference type="STRING" id="441959.B8MMK1"/>
    <dbReference type="GeneID" id="8105444"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_100010"/>
    <dbReference type="eggNOG" id="ENOG502R41Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_1_1_1"/>
    <dbReference type="InParanoid" id="B8MMK1"/>
    <dbReference type="OMA" id="CREKNYV"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="PhylomeDB" id="B8MMK1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED13755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="321" mass="35700" checksum="F16467259DAD7349" modified="2009-03-03" version="1">MTSSSVEIAFARKTQPNSSKYLSDHGIQTIDTAEIYLGSEELLGAASAVSLGFTIDTKVGHGAGGSTTPATKENVIRSGEASLNRLKTNQVDVYYIHGFDQRVPLKDTLEGINELYKKGVFKRFGLSNFSVAEIEDVVRISKERGFVLPTVYEGNYNAINHLIEKKLFSTIRKYNMVFHAYSPIAGGLLAKTPHQIKEGGQGRWDINTFVGKLYYGMYNKPNVMEFLEKFGKIATTKTKCSQAELAYRWIAYHSRLKGELGDKIIGARYGPQLTEVLDALGRGPLSAEVVEEVNGLWDLVKDDPPAEHRTILEELKRSDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMT6</accession>
    <name>B8MMT6_TALSN</name>
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        <submittedName>
            <fullName evidence="13">C6 transcription factor (Gal4), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_100830</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002486035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMT6"/>
    <dbReference type="FunCoup" id="B8MMT6">
        <property type="interactions" value="768"/>
    </dbReference>
    <dbReference type="GeneID" id="8097967"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_100830"/>
    <dbReference type="eggNOG" id="ENOG502QSMN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008599_2_0_1"/>
    <dbReference type="InParanoid" id="B8MMT6"/>
    <dbReference type="OMA" id="PEGTGYF"/>
    <dbReference type="OrthoDB" id="2283488at2759"/>
    <dbReference type="PhylomeDB" id="B8MMT6"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZIP_Gal4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000009">
        <property type="entry name" value="C6 transcription factor (Gal4)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005600">
        <property type="entry name" value="Gal4_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03902">
        <property type="entry name" value="Gal4_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="12">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="86"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED13842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="675" mass="75960" checksum="95A8A5A42931F249" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MN04</accession>
    <name>B8MN04_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_101890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486191.1">
        <property type="nucleotide sequence ID" value="XM_002486146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MN04"/>
    <dbReference type="STRING" id="441959.B8MN04"/>
    <dbReference type="GeneID" id="8099234"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_101890"/>
    <dbReference type="eggNOG" id="ENOG502QZQY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_776353_0_0_1"/>
    <dbReference type="InParanoid" id="B8MN04"/>
    <dbReference type="OMA" id="FEIQSHE"/>
    <dbReference type="OrthoDB" id="3945463at2759"/>
    <dbReference type="PhylomeDB" id="B8MN04"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="210"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="105"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED13953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="298" mass="34684" checksum="DE0A9ED2E541E777" modified="2009-03-03" version="1">MGPKEAQYNNQRLLNEGQSQALIRWINHLTEKGLPLTNSMLANFARDICGRKPGKNWAIRWLRSHSDQVISRYSMGLDMDRKNADKAWKYAIVKEAVNDVYDKKSKKLSNEVHRIQAENALLKAQVEGLQRTVVNLKKRQNKKKPLLLDLHSEKEGGAIFFSPSKVQQARDLQLQKDKNTAQEQARKDDKKLQQKLAREAQKLERIEKAQIRQTKREQRQQEAAEKERQKEEQKLAKLADLQLQKDVLTTPKPCTNQRNPNSKQSKPKISNEAKEEVIEEVIATNRRGRQIRLPVRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8MN95</accession>
    <name>B8MN95_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_107510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486782.1">
        <property type="nucleotide sequence ID" value="XM_002486737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MN95"/>
    <dbReference type="STRING" id="441959.B8MN95"/>
    <dbReference type="GeneID" id="8106780"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_107510"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031555_4_1_1"/>
    <dbReference type="InParanoid" id="B8MN95"/>
    <dbReference type="OMA" id="YYECKTA"/>
    <dbReference type="OrthoDB" id="5326346at2759"/>
    <dbReference type="PhylomeDB" id="B8MN95"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="455" mass="50780" checksum="AC9C1E7B742CCFB5" modified="2009-03-03" version="1">MDSPTHVIDPDGEVIIVLLNVDTTFAEGSEDMIAHGLYNTVSELDEDIKRLEDYTETPKPNPRGKKKKKKGHKNARADLERIPTPIEEPVLVDEPVPVDEPIPVDEPIPVDEPVPVDEPIPADEPVPADEPVPADEPVPVDESIPADEPVPADEPVPADEPVPVDESIPADEPVPAEEPVPEEGPIEQPVESPDRSCFRIQVSAKHLKLASPVFRKMLIGGWKESVACLAPSSVEITAESWDIEALLILLRAIHGQQYHIPRKLTLEMLAKVAVIADYYECKEAVYIWATTWIDALEGELPKTYSRELILWLWISWVFQLSTQFEYATSIAMSRSNGWISGLGLPIPDQVIRAMNKRREEAIDNLIYRLHQIHKDLLNGVRGCGYECSSILYGALAKKMQSNDLLSPRPTAPFPESFGIRVAAVGTSELILFGIWFLKPPRVFRLLLCIPIRWVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNF6</accession>
    <name>B8MNF6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome B-245 heavy chain, putative</fullName>
            <ecNumber evidence="13">1.6.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_102750</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.6.3.1" evidence="13"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486283.1">
        <property type="nucleotide sequence ID" value="XM_002486238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNF6"/>
    <dbReference type="STRING" id="441959.B8MNF6"/>
    <dbReference type="GeneID" id="8101109"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_102750"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005646_3_0_1"/>
    <dbReference type="InParanoid" id="B8MNF6"/>
    <dbReference type="OMA" id="DENQAIH"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="PhylomeDB" id="B8MNF6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000103">
        <property type="entry name" value="NADPH oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000004">
        <property type="entry name" value="NADPH oxidase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000778">
        <property type="entry name" value="Cyt_b245_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF153">
        <property type="entry name" value="SUPEROXIDE-GENERATING NADPH OXIDASE HEAVY CHAIN SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00466">
        <property type="entry name" value="GP91PHOX"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="273"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED14045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="577" mass="66141" checksum="331A600A62C24728" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQ34</accession>
    <name>B8MQ34_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Branched-chain amino acid aminotransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_055620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487171.1">
        <property type="nucleotide sequence ID" value="XM_002487126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQ34"/>
    <dbReference type="STRING" id="441959.B8MQ34"/>
    <dbReference type="GeneID" id="8102255"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_055620"/>
    <dbReference type="eggNOG" id="KOG0975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031922_1_0_1"/>
    <dbReference type="InParanoid" id="B8MQ34"/>
    <dbReference type="OMA" id="MYVAKCN"/>
    <dbReference type="OrthoDB" id="409992at2759"/>
    <dbReference type="PhylomeDB" id="B8MQ34"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009081">
        <property type="term" value="P:branched-chain amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000010">
        <property type="entry name" value="Branched-chain amino acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825">
        <property type="entry name" value="AMINO ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825:SF2">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 3, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED13060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="352" mass="38695" checksum="C67058531818652A" modified="2009-03-03" version="1">MGLPLPKADIEWNGLSALTEVNGHVQSRWNRETGEWSKPEFVSDPFLRVHGLAPIFNYGQGAFEGLKAFRGPNDNEINIFRPEFHALRMKHSASLVSIPQIPESHFLRCVRLAVVNNAEFVPPHSSDGMLYIRPVVFGSGPRILLSPTDEYTFCVYVTPASAYHGIKALDALILEEFDRAAPKGTGSAKVVGNYAPVMKWAEKAKSEGFAITLQLDSQTHTAIDEFSTSAFVGIKNEGEKIKLIIPESSSIIASATSDSIQQIARSFGWEVERRLVKYEELSQFSEVIACGTAATVMPIKSITMKSTADKFVYGNGSSEPGPIASKLGRTIEAMQKGRIKDNFGWITRLADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8MR82</accession>
    <name>B8MR82_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_054850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487088.1">
        <property type="nucleotide sequence ID" value="XM_002487043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MR82"/>
    <dbReference type="STRING" id="441959.B8MR82"/>
    <dbReference type="GeneID" id="8100492"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_054850"/>
    <dbReference type="eggNOG" id="ENOG502S16F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009388_4_1_1"/>
    <dbReference type="InParanoid" id="B8MR82"/>
    <dbReference type="OMA" id="WRWAPRS"/>
    <dbReference type="OrthoDB" id="4227581at2759"/>
    <dbReference type="PhylomeDB" id="B8MR82"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596:SF2">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G17550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="318"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="773" mass="87880" checksum="21EEBEEC07CA80FA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRH8</accession>
    <name>B8MRH8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_056140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487226.1">
        <property type="nucleotide sequence ID" value="XM_002487181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRH8"/>
    <dbReference type="STRING" id="441959.B8MRH8"/>
    <dbReference type="GeneID" id="8100679"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_056140"/>
    <dbReference type="eggNOG" id="ENOG502SU65">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023584_1_0_1"/>
    <dbReference type="InParanoid" id="B8MRH8"/>
    <dbReference type="OMA" id="CWCSAPR"/>
    <dbReference type="OrthoDB" id="342281at2759"/>
    <dbReference type="PhylomeDB" id="B8MRH8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF8">
        <property type="entry name" value="KLAROID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="7">
        <location>
            <begin position="406"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="166"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED13115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="653" mass="72616" checksum="626C5455C4D18B66" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSG8</accession>
    <name>B8MSG8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pogo transposable element</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_000700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED11996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487650.1">
        <property type="nucleotide sequence ID" value="XM_002487605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSG8"/>
    <dbReference type="GeneID" id="8108693"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_000700"/>
    <dbReference type="eggNOG" id="ENOG502S2ZX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_4_0_1"/>
    <dbReference type="InParanoid" id="B8MSG8"/>
    <dbReference type="OMA" id="THIESAW"/>
    <dbReference type="OrthoDB" id="2917041at2759"/>
    <dbReference type="PhylomeDB" id="B8MSG8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="68"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="532"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED11996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="63503" checksum="3DBF243F2A782A3B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSH8</accession>
    <name>B8MSH8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_000780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487660.1">
        <property type="nucleotide sequence ID" value="XM_002487615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSH8"/>
    <dbReference type="GeneID" id="8108701"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_000780"/>
    <dbReference type="HOGENOM" id="CLU_821775_0_0_1"/>
    <dbReference type="InParanoid" id="B8MSH8"/>
    <dbReference type="OMA" id="HENSHTS"/>
    <dbReference type="OrthoDB" id="4369561at2759"/>
    <dbReference type="PhylomeDB" id="B8MSH8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="37295" checksum="87493BF7BFB1EA15" modified="2009-03-03" version="1">MALPDQGLSLRCMPEIATSAPVLEDSTLSDIATLSSASGSPTVSPGQTQQTLSTSIPQPLDPRESSSPIESIESQDILEDFILATLYLSEEFSNSLQNEAVCISSPPPQPVVTPALSHCLDPLQGSPDWSASHDQSHCASQVAEDRDVSVFNNENDAKHVFNIDRDESSEYSRPAKRLKRGHILDTISSTSQETVPRLSPESPLTRQPETPQQEANPESESIPVQGFLKLRYIGSEVVYCLELSQSHVSSLFAGGQTKGTRPSRQEGFSTFRSRKFSPEEDAFIVELKSKNYSWGMIEDRFAQQFPYRSKVSLQVHYCTKLKKLKEKTQISSTTAVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8MT29</accession>
    <name>B8MT29_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_001770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LovG family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487763.1">
        <property type="nucleotide sequence ID" value="XM_002487718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MT29"/>
    <dbReference type="GeneID" id="8098671"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_001770"/>
    <dbReference type="eggNOG" id="KOG2551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051938_0_2_1"/>
    <dbReference type="InParanoid" id="B8MT29"/>
    <dbReference type="OMA" id="DAPFFCD"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="PhylomeDB" id="B8MT29"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF3">
        <property type="entry name" value="ESTERASE DBAE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED12109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="230" mass="25281" checksum="C3A317E538E606F6" modified="2009-03-03" version="1">MSVAPPPKSVSLGNLQLPRILCLHGGGVNAEVFRLQCRALFRSLNGHFRLVFPDAPYLSPADPGVIPTYAHLQPFRRWLRWRIEQPNPGPEAICQDIDKVINVAIANDNALGATGDWVAIMGFSQGAKLAASLLLRQQLRAEKLGQNQTDSSFKFGVLLADHMIRLPSLHVHGRKDPGIADHRRLLTDFCKPGTTRLVEWDGDHRVVIQPADVTAVANEILALSKQTGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTL2</accession>
    <name>B8MTL2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_004640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488072.1">
        <property type="nucleotide sequence ID" value="XM_002488027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTL2"/>
    <dbReference type="STRING" id="441959.B8MTL2"/>
    <dbReference type="GeneID" id="8104448"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_004640"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_12_0_1"/>
    <dbReference type="InParanoid" id="B8MTL2"/>
    <dbReference type="OMA" id="VPTYILM"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="PhylomeDB" id="B8MTL2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="349" mass="37866" checksum="38C5B4E8331D552B" modified="2009-03-03" version="1">MSPIKLLLTGATGYIGGTVLTQLLNSSIPEIKELSISVLIRKPEQAELYASKGVNLITFDGLEDVECLRRVAGEHDIILHAADSTNPSAAEALTLGLADTQGSTKKYFIHTSGTSSLGDRPVTEQLIENREFSDKNDDIYSYLKQREAVESYAQRATDIKTVEVGEKVPGVDTLIIKAPIIHGRGTGFFNQKSFHIPVLIKGAVAAGHAQYVGDGAGIWDYVHVVDLAELFELLVAKILKNDTKGLLTGRKGIYFAGTLRHSWKELAESIAQHCYEAGRLESPTPQSISLQKAADIYTGGDEHIAEVGLASNSLTVADLAREIGWTPKMKETDFQQSLLDDINLLFGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUD2</accession>
    <name>B8MUD2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_108240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488392.1">
        <property type="nucleotide sequence ID" value="XM_002488347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUD2"/>
    <dbReference type="STRING" id="441959.B8MUD2"/>
    <dbReference type="GeneID" id="8106888"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_108240"/>
    <dbReference type="eggNOG" id="ENOG502S7RI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_6_2_1"/>
    <dbReference type="InParanoid" id="B8MUD2"/>
    <dbReference type="OMA" id="WKIAFTS"/>
    <dbReference type="OrthoDB" id="4503213at2759"/>
    <dbReference type="PhylomeDB" id="B8MUD2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="43"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED11636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="321" mass="36814" checksum="2A51800DB5BF444A" modified="2009-03-03" version="1">MDEKGFMLGITTKEKRIFSRRKYEHGGLKQHLQDGNREWITTIASSDSGWTNHELGYQWLVDVFDKETKSQASRGWRLLILDGHGSHVNMRFIEYCDRNRILLAIFPAHATRTLQPLDVALFAPLSKAYTKELRRFLDDCQGLTRLSKRDFFRLFWASWKIAFTSDNINSAFKNTGFYPFNPELAIQRFTQKPEILPSSSESSASIIKAEDWRRISKLVKDAVSNVYEEKAHQLHDTMLHLSTENILLKAQVEGLQRGISNINKRQAKKRTLLLDLPAENEGGAIFFSPSKVQQARDLQLQKDENAAQEQARKDDKASAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUD4</accession>
    <name>B8MUD4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_108260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488394.1">
        <property type="nucleotide sequence ID" value="XM_002488349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUD4"/>
    <dbReference type="GeneID" id="8106890"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_108260"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143030_1_0_1"/>
    <dbReference type="InParanoid" id="B8MUD4"/>
    <dbReference type="OrthoDB" id="4436005at2759"/>
    <dbReference type="PhylomeDB" id="B8MUD4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="111" mass="12149" checksum="B82B2034ABE901BB" modified="2009-03-03" version="1" fragment="single">MSKWHKSTGIFRSPPLKDPLRPNSLPAVTVHEKRDVLVRNLLQNSAEAGDIPLDSPAVPPTSLYFPDISMLQVEESVLQAGNTAPGADEIPTCILKVAWPLIKDKTNRSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUN4</accession>
    <name>B8MUN4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_108840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488458.1">
        <property type="nucleotide sequence ID" value="XM_002488413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUN4"/>
    <dbReference type="GeneID" id="8103140"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_108840"/>
    <dbReference type="HOGENOM" id="CLU_1971962_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUN4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="127" mass="14239" checksum="869F7CD03F86E899" modified="2009-03-03" version="1">MSQTLEVSIPTPVIIRIVFRKINNPKPKVNAEQRANDYVGFLQENIELLEKSLWEKGVRYYVNSYVPLGLGYADLAVAASGLEAVKAAYVTMDMKDEFTERDPLSQLLGVGNVTVGLTTVRITKHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUQ5</accession>
    <name>B8MUQ5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcium/calmodulin dependent protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_109030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488478.1">
        <property type="nucleotide sequence ID" value="XM_002488433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUQ5"/>
    <dbReference type="STRING" id="441959.B8MUQ5"/>
    <dbReference type="GeneID" id="8103159"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109030"/>
    <dbReference type="eggNOG" id="KOG0671">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054430_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUQ5"/>
    <dbReference type="OMA" id="NIMVNCR"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="B8MUQ5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="324" mass="37331" checksum="6B839952FFC617E9" modified="2009-03-03" version="1">MFKRTLTKMTSAPRDYIGASGSCYRFQNVLQERPHIGRVWLATSGLDKFVLKDIPKDIFDNFRENILPRLRKSPYIRLPYDIVPGQQIYIYRYLTDDFLSLVKRGISLRARKQILHNTLLGIAELHDQDVVHLDIKPDNIMVESKQDGEDIIVESVQIIDLENAAYLPKGRCIKGMLAGNENWRSPEAHFKGELNKPTDIFSFAIVCIYAMLGRVIFGPDQDFRKHEAQGALPAFIRLQRQVSYFGDMQGIGGLSKHISDDDISCQVLQMLWDERADEHIDYRPFVDWPDVDPSFKDLIQKLANLDPSKRLTARQALEHPWFLG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2023-02-22" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8MV61</accession>
    <name>TPEC_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome P450 monooxygenase tpeC</fullName>
            <ecNumber evidence="6">1.14.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Polyesters biosynthesis cluster protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tpeC</name>
        <name type="ORF">TSTA_008150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2022" name="Molecules" volume="27" first="0" last="0">
            <title>Putative Biosynthesis of Talarodioxadione &amp; Talarooxime from Talaromyces stipitatus.</title>
            <authorList>
                <person name="Al Fahad A.J."/>
            </authorList>
            <dbReference type="PubMed" id="35889347"/>
            <dbReference type="DOI" id="10.3390/molecules27144473"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="3 6">Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of polyesters containing 2,4-dihydroxy-6-(2-hydroxypropyl)benzoate and 3-hydroxybutyrate moieties, such as talapolyester G, 15G256beta and 15G256beta-2; as well as to oxidized derivatives such as 15G256alpha (PubMed:35889347). The biosynthesis of the polyesters probably starts with the formation of the diketide 3-hydroxybutyryl-S-ACP catalyzed by the partially reducing polyketide synthase tpeA (Probable). The acceptance of 3-hydroxybutyryl by the non-reducing polyketide synthase tpeB would initiate further elongation and cyclization, catalyzed by KS and PT, respectively, to form 2,4-dihydroxy-6-(2-hydroxyn-propyl)benzoyl-S-ACP intermediate (Probable). The TE domain could catalyze lactonization at this step to yield 6-hydroxymellein as a derailment product (Probable). The polyesterification process maybe occurs when additional molecules of 3-hydroxybutyryl are transferred to tpeB (Probable). Following the first esterification step, an intramolecular cyclization catalyzed by the TE domain of tpeB would give talarodioxadione 1, whereas the ethyl esterification of talapolyester G perhaps happens spontaneously (Probable). Further oxidation by the cytochrome P450 monooxygenase tpeC then leads to the formation of oxidized derivatives.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.-.-" evidence="6"/>
    <dbReference type="EMBL" id="EQ962662">
        <property type="protein sequence ID" value="EED11517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962662">
        <property type="protein sequence ID" value="EED11518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488698.1">
        <property type="nucleotide sequence ID" value="XM_002488653.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488699.1">
        <property type="nucleotide sequence ID" value="XM_002488654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MV61"/>
    <dbReference type="SMR" id="B8MV61"/>
    <dbReference type="STRING" id="441959.B8MV61"/>
    <dbReference type="GeneID" id="8110152"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_008150"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4219675at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:heme binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:iron ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000047">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF230">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0349">Heme</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0503">Monooxygenase</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000457629" description="Cytochrome P450 monooxygenase tpeC">
        <location>
            <begin position="1"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P04798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="35889347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="35889347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="35889347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED11517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="507" mass="57301" checksum="638D0A2DB2B3A25D" modified="2009-03-03" version="1">MSHTFHCPQPLLVMIALTIFRYATLAIALIVGFVILKAIYNVFFHPLRNFPGPLRYRASRIFWVLDLIEGRQIYTIDQFHKRYGPVVRTAPDELSFTIPEAWRDIYGHRVGLVSGLPEIPKWPLFYKFTKQDVSIFNAPQGQHGTLRRALAHGFSEKSTRAQESIIGGYVDLLVTRLKEVADSKAPANMVQWYNYTTFDIVGDLVFGNSFHCLDNANYHPWVSLFADSTRQNSIFVGLKILGLDFLALATMPLVIRNMIKHFNLTKEWLRERRKLGTDRGDLIEGLLKKEGEGINFDEIHGTSMGLIFAGSETTATLLSGVTYLLLQNPKTLAKVTMEVRSSFKSDKEITLLSVQNLDYMLACLDEAFRLYPPVGIGLPRQIPKGGVKIAGIYVPEGSIVDVPQYAIHRSPDHWTEPESFHPERFLGDSRFASDKVETLQPFAVGPRNCIGRNLAYAEMRLILARVLYNFDLKMDPSCSGWLDGQKSHALWVKPPLKVQLTPTKATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8MVE9</accession>
    <name>B8MVE9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_007480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962663">
        <property type="protein sequence ID" value="EED11458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488774.1">
        <property type="nucleotide sequence ID" value="XM_002488729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MVE9"/>
    <dbReference type="GeneID" id="8103277"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_007480"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002055_0_0_1"/>
    <dbReference type="InParanoid" id="B8MVE9"/>
    <dbReference type="OMA" id="GRYFICH"/>
    <dbReference type="OrthoDB" id="4948765at2759"/>
    <dbReference type="PhylomeDB" id="B8MVE9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="765"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1037"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1097"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED11458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1255" mass="142717" checksum="F0F8065437BC8694" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8MVF8</accession>
    <name>B8MVF8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_007560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962663">
        <property type="protein sequence ID" value="EED11466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488782.1">
        <property type="nucleotide sequence ID" value="XM_002488737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MVF8"/>
    <dbReference type="STRING" id="441959.B8MVF8"/>
    <dbReference type="GeneID" id="8103285"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_007560"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1653317_0_0_1"/>
    <dbReference type="InParanoid" id="B8MVF8"/>
    <dbReference type="OrthoDB" id="4356562at2759"/>
    <dbReference type="PhylomeDB" id="B8MVF8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18599" checksum="96E3FD2983ED0818" modified="2009-03-03" version="1">MEKLEEPFNKECLFIKNGVILLFYVNDILLFYDKATKQATFKEIEKGLMRKYKLRKMKKFKWFLNIRITCDCAQRKIWLYQDSQITKMASKFRINATNNVKTPISGNIKASTEQATNEEIHAYQELVGSALYVAVITRVDVAKAVNELAKHTKNPSKAHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTB2</accession>
    <name>B8LTB2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pfs, NACHT and WD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_059840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002339873.1">
        <property type="nucleotide sequence ID" value="XM_002339832.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LTB2"/>
    <dbReference type="GeneID" id="8104745"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_059840"/>
    <dbReference type="eggNOG" id="KOG4155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_6_16_1"/>
    <dbReference type="InParanoid" id="B8LTB2"/>
    <dbReference type="OMA" id="ITCHGQN"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="PhylomeDB" id="B8LTB2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035097">
        <property type="term" value="C:histone methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000228">
        <property type="entry name" value="COMPASS-like H3K4 histone methylase component WDR5A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001638">
        <property type="entry name" value="NACHT and WD40 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031469">
        <property type="entry name" value="SesB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
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        <location>
            <begin position="87"/>
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        </location>
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        <location>
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        <location>
            <begin position="724"/>
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        <location>
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        </location>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED22486.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1341" mass="146860" checksum="C991E7FF0E237D2E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUT1</accession>
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        <name evidence="7" type="ORF">TSTA_073280</name>
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        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
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        <property type="entry name" value="Cog5"/>
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            <begin position="13"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20649"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED23938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="472" mass="51101" checksum="B4CA544BF214FE1F" modified="2009-03-03" version="1">MATSEASYIDYDTFLDPDFSASSFANTLVTNTNNINDTQVDLSTPLSRVLFDVQEIDTHIHNLTTKSALPLLEHTKDRSQSSQRILTQVEEQVSSLADGYQRLEKEVLRKWTSAEEARIAAQNSLQTLRLARAVARCITLGRQLEGQIAEVTGRSTTGQKDDHRAMVRAAGTILMLRQMFSAIGEGEEGQGLDRVKVIRTLRSDLVIPAENTTKARAQQVINRFSISSLMVDGTRASNGSQSPPPAAGVPSTYAQTEEAKSRLFSAITTLYLLSPTPKTGVSAEDFQPELLLSTLQGYIHNSLTSSLSSLARGLASLPTLDRALLEVSGRCQDIGALETLLASLKRPSHPLLLPSTNQAADKNNSNLLKPLLSVLDTSSLPSYYWRSLASALPARVQEIMSRGGAAARSLKSSRDRLRSDLRECVLRGSQLPSNVAKGRVINPASGNGAVVEGNWEREAAVMVSSVMGALGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVT7</accession>
    <name>B8LVT7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_075890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="protein sequence ID" value="EED24217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002341563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVT7"/>
    <dbReference type="STRING" id="441959.B8LVT7"/>
    <dbReference type="GeneID" id="8102353"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_075890"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_774280_0_0_1"/>
    <dbReference type="InParanoid" id="B8LVT7"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="PhylomeDB" id="B8LVT7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED24217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="358" mass="38555" checksum="289B6BC09128A5A2" modified="2009-03-03" version="1">MGGQLGFLYRQLTFKPKPIPSSVRLDGKTAIITGANVGLGLKASRELAAHGLTRLILAARNVSKGEAAKKVILEQSPTCDVQVWELDYESFESIRSFGERAQTLDRLDIVILSAGVKSIISAPPPSPFSFSPLQATARSTGTPSRLTIVTSEVHFWTDFNEQKASNIIEELDNPSSSKKGSMDRYNVSKLLDLLWLRELSTKVGSDVTVNGVNPGLCASALHRSHEGSSGFNKVFASPEGQETQQRLFQETLSVLSDALSGVDLMRDNYSNPTIFRLSSHKLFAASSSYAYSTYPGLTGPLLSSAGGLTCTLSKNFPPIPSHSLPTAANQARIHGRSVQALGSETVLDLSRRIDVGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWL8</accession>
    <name>B8LWL8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Salicylate hydroxylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_077740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341802.1">
        <property type="nucleotide sequence ID" value="XM_002341761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWL8"/>
    <dbReference type="STRING" id="441959.B8LWL8"/>
    <dbReference type="GeneID" id="8103971"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_077740"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014528_0_0_1"/>
    <dbReference type="InParanoid" id="B8LWL8"/>
    <dbReference type="OMA" id="MPGPRQT"/>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="PhylomeDB" id="B8LWL8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010451">
        <property type="entry name" value="Acetoacetate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF261">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06314">
        <property type="entry name" value="ADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="14"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED24415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="703" mass="78598" checksum="5E6B122DD64D03D5" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWN2</accession>
    <name>B8LWN2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane fusion protein PRM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_077910</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341816.1">
        <property type="nucleotide sequence ID" value="XM_002341775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWN2"/>
    <dbReference type="FunCoup" id="B8LWN2">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LWN2"/>
    <dbReference type="GeneID" id="8101014"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_077910"/>
    <dbReference type="eggNOG" id="ENOG502QRP5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010191_1_0_1"/>
    <dbReference type="InParanoid" id="B8LWN2"/>
    <dbReference type="OMA" id="NVFGWVN"/>
    <dbReference type="OrthoDB" id="5356111at2759"/>
    <dbReference type="PhylomeDB" id="B8LWN2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032220">
        <property type="term" value="P:plasma membrane fusion involved in cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026777">
        <property type="entry name" value="PRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030:SF1">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0184">Conjugation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="405"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="610"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED24429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="735" mass="79863" checksum="6B31E959F09AA628" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWT2</accession>
    <name>B8LWT2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heat shock transcription factor Hsf1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_079210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341952.1">
        <property type="nucleotide sequence ID" value="XM_002341911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWT2"/>
    <dbReference type="STRING" id="441959.B8LWT2"/>
    <dbReference type="GeneID" id="8105980"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_079210"/>
    <dbReference type="eggNOG" id="KOG0627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013966_0_0_1"/>
    <dbReference type="InParanoid" id="B8LWT2"/>
    <dbReference type="OMA" id="QWGQNPP"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="PhylomeDB" id="B8LWT2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000173">
        <property type="entry name" value="Heat shock transcription factor Hsf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="7">
        <location>
            <begin position="146"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="253"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="728"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="552"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="731"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="762"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED24565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="800" mass="87956" checksum="4233F56E23D64453" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8LX75</accession>
    <name>B8LX75_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chaperone protein DNAj, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_062130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340112.1">
        <property type="nucleotide sequence ID" value="XM_002340071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LX75"/>
    <dbReference type="STRING" id="441959.B8LX75"/>
    <dbReference type="GeneID" id="8101042"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_062130"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_687308_0_0_1"/>
    <dbReference type="InParanoid" id="B8LX75"/>
    <dbReference type="OMA" id="QDVIPHF"/>
    <dbReference type="OrthoDB" id="10265645at2759"/>
    <dbReference type="PhylomeDB" id="B8LX75"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="6"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED22725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="401" mass="45950" checksum="2170EE9366442050" modified="2009-03-03" version="1">MGKSKDYYKILHVNPDLDQDGIKKQYRHLAKQYHPDKHPGEEAVYNSKFQDLQEAYDILSNEKKRKEYDRNRWTTYASNTPSSAGQRTGWNRQEGFPKRDPLFQQRGNAGPNYGNPGTSRSSFQQNSASTKHPNWKGFNAGSFRSPNMFPRESSTKHMNAKRQGFNPGTASGDEPMASGTSSYSKARRSDHISEIFESVPEARPQSQGGERTHLSREDISRDNLGAGSVDPPLTKDGEGKEAKTRQTDSTTPEMPPNTNPTAPVPSSHYRRPYVSTEDEENATSETVTSDAPFQSSDFQLPQPPILNVEQNDLHKNLEEITLYIMKWSDFQREVIQKLSETRVTHIEAVARNIKVSSDIMKRQREAYEEYTRIRKHWNIAQEQYQKCILRLTEIYRSLRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXX3</accession>
    <name>B8LXX3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C6 finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_062750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340175.1">
        <property type="nucleotide sequence ID" value="XM_002340134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXX3"/>
    <dbReference type="STRING" id="441959.B8LXX3"/>
    <dbReference type="GeneID" id="8105964"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_062750"/>
    <dbReference type="eggNOG" id="ENOG502S89Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_756883_0_0_1"/>
    <dbReference type="InParanoid" id="B8LXX3"/>
    <dbReference type="OMA" id="WYMRALQ"/>
    <dbReference type="OrthoDB" id="3525185at2759"/>
    <dbReference type="PhylomeDB" id="B8LXX3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877169" description="C6 finger domain protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED22788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="41992" checksum="9738AACA46B66989" modified="2009-03-03" version="1">MRAALLAPSLILLALQSKQHNVLKEALKWYDRGLSYMRTRLKNLDNIVPDEVEGHFLICAALFMSIYETLQTTVVGGYEQHVIGAVTLLQAKGPELFAKREYHDLFLAVRGHAIHVSLIKGKPTCFANDEWLSTPFTQLPKSLSERINDMLLLIPRYLHELQIELFNTFDELERHNVRKAFMHKIGSVKRDLDEIRRRKSQSLKRVRSRERSVPNSEDDDNPLYHTSYEYTSPIQARIVAMEACARIIIMSIELSSTTRTPPWPCFFPIEDWNNENLTIEVEGASRDIIFASQYLSRFMIGCAYIRMILPLQVVAQMSPNHDQRVTARNILESWYKETPIKGLTTRALQAIDAPSNHRLVSGSLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8LY89</accession>
    <name>B8LY89_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_067660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340721.1">
        <property type="nucleotide sequence ID" value="XM_002340680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LY89"/>
    <dbReference type="STRING" id="441959.B8LY89"/>
    <dbReference type="GeneID" id="8099933"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_067660"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_1_4_1"/>
    <dbReference type="InParanoid" id="B8LY89"/>
    <dbReference type="OMA" id="NFRIVTR"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="PhylomeDB" id="B8LY89"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF54">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED23334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="30829" checksum="96E6EAB1FA92629C" modified="2009-03-03" version="1">MGAFPNLYGLGADGIKNFEVLLADGRLINANANENGDLYRALKGGGSNFRIVTRFGIETHPLINVQYTINLYNPEDYVEIIKATIAVQETIEDDPKIGLFTNFNHGFVAVSLLYGDTPAQSPLAFEPFYNLTSLITTVVPATNAISTVTTKVSRELYEEAYKSWIETSKSLPVGCVLHFTIQPMGKAGVQAGKDRGENILGLESVPQCWWVFTCEWPKDGSDDAAAQKAVDSSQKVLRSYGTENVKRMQDVAVKYDPEGIFQKLQHNGFLLRNTSEYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYK4</accession>
    <name>B8LYK4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ubiquitin C-terminal hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_067910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="414"/>
            <end position="546"/>
        </location>
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    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="737"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="558"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1012"/>
            <end position="1033"/>
        </location>
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        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <begin position="251"/>
            <end position="263"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1012"/>
            <end position="1025"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED23362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1110" mass="124000" checksum="23B7033344ED64A2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYP4</accession>
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            <fullName evidence="16">Nuclear membrane fusion protein Kar5, putative</fullName>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <text evidence="1">Required for nuclear membrane fusion during karyogamy.</text>
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        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
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    </comment>
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        <text evidence="4">Belongs to the KAR5 family.</text>
    </comment>
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    </dbReference>
    <dbReference type="STRING" id="441959.B8LYP4"/>
    <dbReference type="GeneID" id="8108519"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_068280"/>
    <dbReference type="eggNOG" id="ENOG502QVCQ">
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:karyogamy involved in conjugation with cellular fusion"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:nuclear membrane fusion involved in karyogamy"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007292">
        <property type="entry name" value="Nuclear_fusion_Kar5"/>
    </dbReference>
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        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
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    </dbReference>
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        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
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        <location>
            <begin position="20"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="207"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003389"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EED23402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="531" mass="58592" checksum="527CD87FD29ADD47" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZ97</accession>
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        <submittedName>
            <fullName evidence="6">ATP-dependent Clp protease, putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">TSTA_088860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED21650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002478568.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="B8LZ97">
        <property type="interactions" value="661"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LZ97"/>
    <dbReference type="GeneID" id="8106983"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_088860"/>
    <dbReference type="eggNOG" id="KOG0745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014218_1_2_1"/>
    <dbReference type="InParanoid" id="B8LZ97"/>
    <dbReference type="OMA" id="HRSDFTN"/>
    <dbReference type="OrthoDB" id="1721884at2759"/>
    <dbReference type="PhylomeDB" id="B8LZ97"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000138">
        <property type="entry name" value="ATP-dependent Clp protease ATP-binding subunit ClpX"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ATPase_AAA_core"/>
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        <property type="entry name" value="Clp_ATPase_C"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF7">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="188"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="5">
        <location>
            <begin position="469"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="298"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="581"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="382"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="588"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED21650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="621" mass="67635" checksum="340E651793ACB468" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZQ4</accession>
    <name>B8LZQ4_TALSN</name>
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        <submittedName>
            <fullName evidence="9 10">Cytochrome P450, putative</fullName>
        </submittedName>
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        <name evidence="9" type="ORF">TSTA_000650</name>
        <name evidence="10" type="ORF">TSTA_080690</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED11991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EED20836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477799.1">
        <property type="nucleotide sequence ID" value="XM_002477754.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002487600.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="8101373"/>
    <dbReference type="GeneID" id="8108688"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_000650"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_11_1"/>
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    <dbReference type="OrthoDB" id="4219675at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:iron ion binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:monooxygenase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
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        <property type="entry name" value="Cytochrome P450"/>
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        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
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        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="EP450I"/>
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        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
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    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED11991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED20836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="494" mass="55619" checksum="FE5A9770CA641C91" modified="2009-03-03" version="1">MISFLIFSVLMAGLLFAIKRLYFHPLSRFNGPRFWALTLLPYMLAFRSGQLAHKVKGFHEIYGDTVRVGPNEISFINPHSVKDIYNKRPNAQFKTLPKDPVRQPPTRPGHPCSILEAGDEDHSRIRKAYATLFSTQALRAQEPLIVSYVLKMTSQLKTRGSQNDGIVDLQKWFTYCVFDVICSLSFGEDFGCLENDRYHEWVGALVFSLKAKVQLASSRYYPWLFNLLVKLMSQSAQAKLIEHKRITREKVQKRLGQHTVRPDFLSYLQASKHDLTEGEIVTNAETLIIAGSHTLQTAITGIVFQLLHNPEALGRVTNEIRDAFASETDMDTKSLMQLPMLGAAIKEGMRLTSPVPLGLTRRVPDGGAIICGSYFPSGTVVSYMQWAANLSGSNYTDPNRFDLERWLDSDSGAGSRYKNDRKETTQPYLQGPRDCLGQNLAQSEIVLILGHLLYNFDISLPEGLGSQAVNNWEDQETYAVWVGNPLPVRLSPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZX2</accession>
    <name>B8LZX2_TALSN</name>
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        <submittedName>
            <fullName evidence="9">Siderophore iron transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_081370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477867.1">
        <property type="nucleotide sequence ID" value="XM_002477822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZX2"/>
    <dbReference type="GeneID" id="8104775"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_081370"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_25_2_1"/>
    <dbReference type="InParanoid" id="B8LZX2"/>
    <dbReference type="OMA" id="SYAWHSA"/>
    <dbReference type="OrthoDB" id="4220942at2759"/>
    <dbReference type="PhylomeDB" id="B8LZX2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06179">
        <property type="entry name" value="MFS_TRI12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053791">
        <property type="entry name" value="MFS_Tri12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="41"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED20904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="578" mass="60985" checksum="F8B3BD3FD2A8F98C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZZ5</accession>
    <name>B8LZZ5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dynamin GTPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_081600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477890.1">
        <property type="nucleotide sequence ID" value="XM_002477845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZZ5"/>
    <dbReference type="STRING" id="441959.B8LZZ5"/>
    <dbReference type="GeneID" id="8104798"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_081600"/>
    <dbReference type="eggNOG" id="KOG0446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008964_7_1_1"/>
    <dbReference type="InParanoid" id="B8LZZ5"/>
    <dbReference type="OMA" id="HQKGHPI"/>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="PhylomeDB" id="B8LZZ5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001425">
        <property type="entry name" value="Dynamin GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF21">
        <property type="entry name" value="DYNAMIN RELATED PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="6">
        <location>
            <begin position="35"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="5">
        <location>
            <begin position="607"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="810"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="831"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED20927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="859" mass="95586" checksum="7EDA72B820ED9C45" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B8M035</accession>
    <name>B8M035_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_082000</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477930.1">
        <property type="nucleotide sequence ID" value="XM_002477885.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M035"/>
    <dbReference type="GeneID" id="8104838"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_082000"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="InParanoid" id="B8M035"/>
    <dbReference type="OMA" id="QYWSDQS"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="PhylomeDB" id="B8M035"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001010">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="521"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="596"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="630"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="663"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="691"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="766"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1186"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1251"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <begin position="1446"/>
            <end position="1464"/>
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            <end position="410"/>
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            <end position="1086"/>
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        <location>
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            <end position="830"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022741"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED20967.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
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    <sequence length="1484" mass="165890" checksum="BF3E42841830F564" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0J5</accession>
    <name>B8M0J5_TALSN</name>
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        <submittedName>
            <fullName evidence="9">Efflux pump antibiotic resistance protein, putative</fullName>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
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    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
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            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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    </feature>
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        <location>
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            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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    </feature>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        <location>
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            <begin position="51"/>
            <end position="538"/>
        </location>
    </feature>
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        <location>
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            <end position="37"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED21292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="549" mass="58100" checksum="0A689BA0DB9721C9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0N4</accession>
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        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_086500</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
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            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with the U3 snoRNA and is associated with the 90S and 40S pre-ribosomes.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="EED21417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002478335.1"/>
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    <dbReference type="STRING" id="441959.B8M0N4"/>
    <dbReference type="GeneID" id="8110056"/>
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    <dbReference type="HOGENOM" id="CLU_003041_1_4_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:RNA helicase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:maturation of SSU-rRNA"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DEADc_DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DDX52/Rok1_DEADc"/>
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        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3 10 14" id="KW-0347">Helicase</keyword>
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    <keyword evidence="1 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="243"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="508"/>
            <end position="665"/>
        </location>
    </feature>
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        </location>
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        <location>
            <begin position="155"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="328"/>
            <end position="370"/>
        </location>
    </feature>
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        <location>
            <begin position="687"/>
            <end position="748"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
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        <location>
            <begin position="90"/>
            <end position="119"/>
        </location>
    </feature>
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        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
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        <location>
            <begin position="696"/>
            <end position="706"/>
        </location>
    </feature>
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        <location>
            <begin position="707"/>
            <end position="716"/>
        </location>
    </feature>
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        <location>
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            <end position="734"/>
        </location>
    </feature>
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        <location>
            <begin position="739"/>
            <end position="748"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED21417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="748" mass="82541" checksum="4F0CF461525FF1B9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0U9</accession>
    <name>B8M0U9_TALSN</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">TSTA_089660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002478647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0U9"/>
    <dbReference type="STRING" id="441959.B8M0U9"/>
    <dbReference type="GeneID" id="8104933"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_089660"/>
    <dbReference type="eggNOG" id="ENOG502SA1F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058677_2_0_1"/>
    <dbReference type="InParanoid" id="B8M0U9"/>
    <dbReference type="OMA" id="VTIMEPP"/>
    <dbReference type="OrthoDB" id="5384020at2759"/>
    <dbReference type="PhylomeDB" id="B8M0U9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="209" mass="22430" checksum="A7B2D2618D804F8D" modified="2009-03-03" version="1">MSNSTGNASSFPNPITTAAAANAQSGPRRMSITTLGLSGSPTQPSPFSAYVGRRESLSSSESYEDAIEDNDNSPANNPTSPLARRVSFGAQALRDVRGGSGSGNGTSTQKLKNERSDHSWRPLGEGFNWSAALRTRAERAPSIGGSMPTSSHAQPAMLNPNDPNASKAYHQRAASIAIMEQPTHEIPREPRQNKPDFFQEKILRADFMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8M118</accession>
    <name>B8M118_TALSN</name>
    <protein>
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        </alternativeName>
    </protein>
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        <name evidence="11" type="ORF">TSTA_090370</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal proline from a peptide.</text>
            <dbReference type="EC" id="3.4.11.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S33 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002478716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M118"/>
    <dbReference type="STRING" id="441959.B8M118"/>
    <dbReference type="MEROPS" id="S33.001"/>
    <dbReference type="GeneID" id="8108125"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_090370"/>
    <dbReference type="eggNOG" id="ENOG502QPPY">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043739_2_0_1"/>
    <dbReference type="InParanoid" id="B8M118"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="PhylomeDB" id="B8M118"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005944">
        <property type="entry name" value="Pro_iminopeptidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43722">
        <property type="entry name" value="PROLINE IMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43722:SF1">
        <property type="entry name" value="PROLINE IMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="10">
        <location>
            <begin position="36"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED21798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="205" mass="23501" checksum="62E81032A08D851E" modified="2009-03-03" version="1">MDSKGYTHDPPFDRGYLSVGAIHKLHYAQYGNRNGKPVIFLHGGPGGNTSFANTTYFNPDIYRVILYDQRGAGKSLPTACTEENTTHHLIEDIEALRKHLGISKWFMLFGGSWGATLALLYAQRYPERVGSMVLRGIFTARQPEINWTRMPDSGAARMWPAEYEKFLNFLPEEERRNPPESYCKYILNISTDEETKRKRYEAALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1J8</accession>
    <name>B8M1J8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_093310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479048.1">
        <property type="nucleotide sequence ID" value="XM_002479003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1J8"/>
    <dbReference type="STRING" id="441959.B8M1J8"/>
    <dbReference type="GeneID" id="8102575"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_093310"/>
    <dbReference type="eggNOG" id="ENOG502QSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_1_2_1"/>
    <dbReference type="InParanoid" id="B8M1J8"/>
    <dbReference type="OMA" id="IHTRTIC"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="PhylomeDB" id="B8M1J8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF31">
        <property type="entry name" value="LAEA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="40118" checksum="44CCE15E687E64B6" modified="2009-03-03" version="1">MNPEHSDSDSGSIFTVKTNTTAPTEWTSEEGIDPHDESDVMSVLESLYGGDSTYSLSSSVLNYHFENGRRYHAYHEGKYIMPNDDQEQNKLMLMHLCYALVFDGRLHLSPISTNPQNVLDIGTGRGDWAIDFAEAYPSARVIGTDLSPIQPLWVPPNCTFEIDDAEDEWLYTQQFDLIHTRTICGAIRDWPRFHRQAFDHVKPGGWFEMQENDAWFQRDDGSCPEWTQMFLEKLDEASILSGRRLNVARDQKQYMIDAGFINVHDVIFRLPLSPWHSDPRMKEIGRLRGLAMNEGVEGYSLALYTRFLGWSPNEVRILLAKVRSEFNDVRNQMYIAVHVVYGQKPEEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1V5</accession>
    <name>B8M1V5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PAN2-PAN3 deadenylation complex subunit PAN3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Poly(A)-nuclease deadenylation complex subunit 3</fullName>
            <shortName evidence="10">PAN deadenylation complex subunit 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PAN3</name>
        <name evidence="15" type="ORF">TSTA_085640</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PAB1 (via PABC domain), conferring substrate specificity of the enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The N-terminal zinc finger binds to poly(A) RNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. PAN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478296.1">
        <property type="nucleotide sequence ID" value="XM_002478251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1V5"/>
    <dbReference type="FunCoup" id="B8M1V5">
        <property type="interactions" value="644"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M1V5"/>
    <dbReference type="GeneID" id="8104529"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_085640"/>
    <dbReference type="eggNOG" id="KOG3741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016423_1_0_1"/>
    <dbReference type="InParanoid" id="B8M1V5"/>
    <dbReference type="OMA" id="YVFHSVD"/>
    <dbReference type="OrthoDB" id="204958at2759"/>
    <dbReference type="PhylomeDB" id="B8M1V5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3700:FF:000001">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex subunit PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000520">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex subunit PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5160:FF:000002">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex subunit PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03181">
        <property type="entry name" value="PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030844">
        <property type="entry name" value="PAN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041332">
        <property type="entry name" value="Pan3_CK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272">
        <property type="entry name" value="DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272:SF11">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18101">
        <property type="entry name" value="Pan3_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25586">
        <property type="entry name" value="zf-CCCH_PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="279"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="57"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Knob domain" evidence="10">
        <location>
            <begin position="556"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="517"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="357"/>
            <end position="364"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="416"/>
            <end position="417"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED21333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="653" mass="72125" checksum="2E657C6AB686DBC4" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1Z5</accession>
    <name>B8M1Z5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF803 domain membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_086040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478336.1">
        <property type="nucleotide sequence ID" value="XM_002478291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1Z5"/>
    <dbReference type="GeneID" id="8104569"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_086040"/>
    <dbReference type="eggNOG" id="KOG2922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012349_0_0_1"/>
    <dbReference type="InParanoid" id="B8M1Z5"/>
    <dbReference type="OMA" id="PMVYISI"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="PhylomeDB" id="B8M1Z5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF85">
        <property type="entry name" value="DUF803 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G15880)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="300"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="368"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="384"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED21373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="400" mass="43131" checksum="717E88DBBAA59CA3" modified="2009-03-03" version="1">MVSDKYVGLALAIVSTLAIGTSFVITKKGLLHASETHGFEGEGFSYLRSPIWWGGIATLAIGEIANFAAYAFAPAILVTPLGALSVLIGAVLGSYFLNERLGTLGKLGCAMCLLGSVVIVLHAPPDKPVETIDEILDYALSPGFLLYCAAVAIFSTVMIYRVAPVHGKKNPLIYISICSTVGSVSVMSIKAFGIALKLTFNGNNQFTHASTYVFAIVTAFCILTQMNYFNKALSEFSTNIVNPLYYVTFTTATLCASFILFKGFNTTDAVNTISLLCGFLVIFSGVYLLNLSRHDPDGRQTLASKDDEDDGVPTDGIASFGTRRSMQARRSMDPHRRSSSSIAFLNGQGDREGLMRAYDAENGVIGLTELREEDDGAPGSTRKSHIDESRSSFHSKQDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8M230</accession>
    <name>B8M230_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Nucleolar protein family A member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_087300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Common component of the spliceosome and rRNA processing machinery.</text>
    </comment>
    <comment type="function">
        <text evidence="3">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478457.1">
        <property type="nucleotide sequence ID" value="XM_002478412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M230"/>
    <dbReference type="STRING" id="441959.B8M230"/>
    <dbReference type="GeneID" id="8100859"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_087300"/>
    <dbReference type="eggNOG" id="KOG3167">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084513_0_0_1"/>
    <dbReference type="InParanoid" id="B8M230"/>
    <dbReference type="OMA" id="HGIPYVY"/>
    <dbReference type="OrthoDB" id="5364946at2759"/>
    <dbReference type="PhylomeDB" id="B8M230"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000027">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="5">
        <location>
            <begin position="95"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED21494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="233" mass="25331" checksum="79F4E0FCE9CAB5AD" modified="2009-03-03" version="1">MGKDKSEKKEKKEKKEKKRSETDGVHKQKKEKKEKKLSEVVEKELTAQVLEGLEKKKDVSEGAVVNGTIAEVTVKPIGALVPFANPLAEDKTAKKVFKTVKKAAVNKSLKRGVKEVVKALRKSPTPAANAPITDPVGVVILAADISPLDVISHIPVLCEDHGIPYVFVTSRAELGAAGATKRPTSVVMVTPKSGKKSKKSDKKEEDGADEEDFSKVYAELVKLALKEQEKVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2B5</accession>
    <name>B8M2B5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_088150</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478542.1">
        <property type="nucleotide sequence ID" value="XM_002478497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2B5"/>
    <dbReference type="FunCoup" id="B8M2B5">
        <property type="interactions" value="852"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M2B5"/>
    <dbReference type="GeneID" id="8106912"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_088150"/>
    <dbReference type="eggNOG" id="KOG2099">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010198_1_1_1"/>
    <dbReference type="InParanoid" id="B8M2B5"/>
    <dbReference type="OMA" id="WLKQANP"/>
    <dbReference type="OrthoDB" id="9215500at2759"/>
    <dbReference type="PhylomeDB" id="B8M2B5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04300">
        <property type="entry name" value="GT35_Glycogen_Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000002">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000003">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF3">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE, LIVER FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 10 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 11" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED21579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="879" mass="100674" checksum="5BB4D212012CD520" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2S5</accession>
    <name>B8M2S5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_094260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479143.1">
        <property type="nucleotide sequence ID" value="XM_002479098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2S5"/>
    <dbReference type="STRING" id="441959.B8M2S5"/>
    <dbReference type="GeneID" id="8103754"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_094260"/>
    <dbReference type="eggNOG" id="ENOG502RYN6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019101_2_3_1"/>
    <dbReference type="InParanoid" id="B8M2S5"/>
    <dbReference type="OMA" id="NKVYCLV"/>
    <dbReference type="OrthoDB" id="3903189at2759"/>
    <dbReference type="PhylomeDB" id="B8M2S5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF149">
        <property type="entry name" value="UBID FAMILY DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="28"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="329"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="373"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED22180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="399" mass="44775" checksum="9147E78621CA3D53" modified="2009-03-03" version="1">MSTSSGFAEHFRNETWALYGVAVFGTVLRFIARIRRLGIRHLQIDDYLMVFGVIWYTILCVALNKVASGGGSNLMTEEDIQNLTPSSYAERVRGSKWVFVSEHAFILCVWSCKSCMLVIYARLTDGLAQKRLINYCAIYVGLGFVAVELALFLSCIPLQNYWAVPTPNPQCSSYQHYEIVQACFSITADIFMLLVAIPLLVKIQLPLRQKFILVLLFGMGVFEIVAAILTKIYCLVPSLISYIYMNWYFREATVSMLVTNLPLIWSLLRDIFPNLLNSWTGGSRKGADRYYPSMPFSSTTRSKGTRTYGMNSQVQSTNPAHYDLEEFTSKTQKNNSTMSVTHADSDSADLNSDDGSDRALRIRQDITVTVEAGPRQEPIGAAISQPHGWEVKRAEAPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2X3</accession>
    <name>B8M2X3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_094740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479191.1">
        <property type="nucleotide sequence ID" value="XM_002479146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2X3"/>
    <dbReference type="STRING" id="441959.B8M2X3"/>
    <dbReference type="GeneID" id="8103804"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_094740"/>
    <dbReference type="eggNOG" id="ENOG502S8N8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075873_0_0_1"/>
    <dbReference type="InParanoid" id="B8M2X3"/>
    <dbReference type="OrthoDB" id="4226771at2759"/>
    <dbReference type="PhylomeDB" id="B8M2X3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED22228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="381" mass="43461" checksum="2F9141FB61557F50" modified="2009-03-03" version="1">MSRQQKILFPKINSSIPGYRYPESINTFNRRGDEKPTHRVFRTKRKHVQRACERCRVKKAKCDGNQPCSRCVTYNQACIFRDRKATQEKVYSRGFVEMLISQHAVHIQALRDLYKRCVRREGFPGSPLQESIQGYPGTHAILDRLGLIKHAEEAIEDPQKVLADIVEYIKRLDPASDCCLDSVESTTDTSETTVSEELSPEPNTPRESPDLSVPSNASTWKTATSEEARLCHAYGDYKPMHSQYAADIPLAGSTDDACAIRTDDFTEVSWNYYPSQVRYTPAGTDTASYTRTESFESSWPEIADHPSATFMPMTSRATASEPLIYTTEQSDFSHGYAYTQGHEHLTGPIQREHQHQHQHQRQLRHSVDYGLMNTAEHYVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4J1</accession>
    <name>B8M4J1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrodipicolinate synthetase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_025080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479620.1">
        <property type="nucleotide sequence ID" value="XM_002479575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4J1"/>
    <dbReference type="GeneID" id="8106725"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_025080"/>
    <dbReference type="eggNOG" id="ENOG502RBA9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_4_1_1"/>
    <dbReference type="InParanoid" id="B8M4J1"/>
    <dbReference type="OMA" id="PHHWLRF"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="PhylomeDB" id="B8M4J1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF38">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHETASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G00110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="343" mass="37439" checksum="5BAEA05675A63454" modified="2009-03-03" version="1">MTRKEALRAFMQGWGKLHGFQKGCYRTPVFKTVNMVGFDMRGLTPAPVTPFTPDGAVDYEAIHRLGSWLGSIDGVKGLVVLGHAGEGTFLTPQEQESVVKAFVKSVDNKTPIIAGITGEGTEVAALEAKRAKDAGAAAGLLYPSHGWLRFGYQPGAPQDRYKRVYEASGLPLILFQYPDNTKATYSLQTMLDISAQPGVFAMKNGVRNMRRWDTEIPVIRRERPDLQILSCHDEYLLHTAFDVDGFLVGYGNIAPEPLIELIAAGKEKDYKKARAIHDQLLPVTKSVYHRGSHMEGTVALKHALVARGILTHATTRSPLLPLEPGAEQEIHAAISAAALSKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4S6</accession>
    <name>B8M4S6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SAGA-associated factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_026670</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the SGF11 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479795.1">
        <property type="nucleotide sequence ID" value="XM_002479750.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479796.1">
        <property type="nucleotide sequence ID" value="XM_002479751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4S6"/>
    <dbReference type="STRING" id="441959.B8M4S6"/>
    <dbReference type="GeneID" id="8098948"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_026670"/>
    <dbReference type="eggNOG" id="ENOG502S8VT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051868_0_0_1"/>
    <dbReference type="InParanoid" id="B8M4S6"/>
    <dbReference type="OMA" id="NCPRYFL"/>
    <dbReference type="OrthoDB" id="21557at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070461">
        <property type="term" value="C:SAGA-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013246">
        <property type="entry name" value="SAGA_su_Sgf11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08209">
        <property type="entry name" value="Sgf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="127"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="223"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="302"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU261113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED19361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="317" mass="34150" checksum="7C274947240755B9" modified="2009-03-03" version="1">MAGPDSDKTAEISSRVCTAASFSELSKEILNATFYNIIHDIVAKVHRDEKVARMRSAVVLARQKAEAEAEAGGIPEKKVQVETEGAICENGKVYLKGNPLATTKDIVCPFCRLPRLLYPTMGIGARPPPDPSKEYCTKHPLVSRPGYDVHGNPFATDKTKKKKKNTNTNTPISSPPSTPDANGTSKQNAPDYPTIKCPNCPRYCQTNRVAAHLDRCMGISGRTVTRNREGGSATPATTGPPKRPFPDDDVAPMNFKKKKPNTPKKLGTNKPAPPSKLKKAATPDTMLAEEAAEAAEAAESAESFHDPSVDGEEKVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4T6</accession>
    <name>B8M4T6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_026770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479805.1">
        <property type="nucleotide sequence ID" value="XM_002479760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4T6"/>
    <dbReference type="STRING" id="441959.B8M4T6"/>
    <dbReference type="GeneID" id="8098957"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_026770"/>
    <dbReference type="eggNOG" id="ENOG502S3E8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066479_0_0_1"/>
    <dbReference type="InParanoid" id="B8M4T6"/>
    <dbReference type="OMA" id="LGQCPLT"/>
    <dbReference type="OrthoDB" id="2279611at2759"/>
    <dbReference type="PhylomeDB" id="B8M4T6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="24584" checksum="767574C8DF54A582" modified="2009-03-03" version="1">MKVDTVLLSYAGANFLYMAGGIMLLVGSLLFSQTINSTPTLDSAPAIVLLEMVPEKVALVNAIFVFATFVLVLPTMILRTSRIWLKLQGWMVIVSGLFTLVIGLIIWIETLRTRATLNTSWGKQTPEVQSLLQQRFDCCGYYNSTSPPFVTDATCSTPLIAAEKQGCVGPFSSFVNSTLDAIFTGIFGIVAFDMILLISVAVVSKDRKEKERYRLIDAKIGVGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4U5</accession>
    <name>B8M4U5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">tRNA-splicing endonuclease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_026850</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479814.1">
        <property type="nucleotide sequence ID" value="XM_002479769.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M4U5"/>
    <dbReference type="GeneID" id="8098965"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_026850"/>
    <dbReference type="eggNOG" id="KOG1801">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000459_0_0_1"/>
    <dbReference type="InParanoid" id="B8M4U5"/>
    <dbReference type="OMA" id="WHSTELL"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="PhylomeDB" id="B8M4U5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001147">
        <property type="term" value="F:transcription termination site sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18042">
        <property type="entry name" value="DEXXQc_SETX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001152">
        <property type="entry name" value="tRNA-splicing endonuclease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024481">
        <property type="entry name" value="Helicase_Sen1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056474">
        <property type="entry name" value="SEN1_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23576">
        <property type="entry name" value="SEN1_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12726">
        <property type="entry name" value="SEN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="11">
        <location>
            <begin position="1212"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="197"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="270"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1120"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1251"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="761"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1121"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1251"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1268"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1380"/>
            <end position="1391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED19380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1391" mass="154188" checksum="2CD42D6238ED84A4" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8M552</accession>
    <name>B8M552_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldo-keto reductase family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_029350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480092.1">
        <property type="nucleotide sequence ID" value="XM_002480047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M552"/>
    <dbReference type="STRING" id="441959.B8M552"/>
    <dbReference type="GeneID" id="8099054"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_029350"/>
    <dbReference type="HOGENOM" id="CLU_2335058_0_0_1"/>
    <dbReference type="InParanoid" id="B8M552"/>
    <dbReference type="OrthoDB" id="1659429at2759"/>
    <dbReference type="PhylomeDB" id="B8M552"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED19658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="98" mass="10755" checksum="7E09F51E10C63000" modified="2009-03-03" version="1">MAKTVGVTNYDKDEMIKLVEELEKLGVPLATNQGDCRRQKRMSVVAVQLNFCICKGAVPVVGVGVSDDEQVRQNLQAEMMVIDDVSVEGTTTALWQRG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-09-21" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5K5</accession>
    <name>SEC11_TALSN</name>
    <protein>
        <recommendedName>
            <fullName>Signal peptidase complex catalytic subunit sec11</fullName>
            <ecNumber evidence="1">3.4.21.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Signal peptidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">sec11</name>
        <name type="ORF">TSTA_031580</name>
    </gene>
    <organism>
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1 2">Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3 (By similarity). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity). SPC associates with the translocon complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The C-terminal short (CTS) helix is essential for catalytic activity. It may be accommodated as a transmembrane helix in the thinned membrane environment of the complex, similarly to the signal peptide in the complex substrates.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S26B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="1"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480333.1">
        <property type="nucleotide sequence ID" value="XM_002480288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5K5"/>
    <dbReference type="SMR" id="B8M5K5"/>
    <dbReference type="FunCoup" id="B8M5K5">
        <property type="interactions" value="665"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M5K5"/>
    <dbReference type="MEROPS" id="S26.010"/>
    <dbReference type="GlyCosmos" id="B8M5K5">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="GeneID" id="8107769"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_031580"/>
    <dbReference type="eggNOG" id="KOG3342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089996_0_0_1"/>
    <dbReference type="InParanoid" id="B8M5K5"/>
    <dbReference type="OMA" id="ILMNEYP"/>
    <dbReference type="OrthoDB" id="10257561at2759"/>
    <dbReference type="PhylomeDB" id="B8M5K5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0735">Signal-anchor</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000412367" description="Signal peptidase complex catalytic subunit sec11">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Signal-anchor for type II membrane protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="3">
        <location>
            <begin position="40"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal short (CTS) helix" evidence="2">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P15367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P67812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="191" mass="21110" checksum="32D23773221156C7" modified="2009-03-03" version="1">MLSALGGNLSNARQSIAQVLNFALVLSTAFMLWKGVSIVSNSSSPIVVVLSGSMEPAFQRGDLLFLWNRGERAEVGEIVVYNVRGKDIPIVHRVVRSYTEEDKKLKAKKTKAGLPYVAPQKLLTKGDNNLADDTELYARGQEFLDRKEDIVGSVRGYIPGVGYVTIMLSEHPWLKTVLLGVMGLMVVFQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8M672</accession>
    <name>B8M672_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_024050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479506.1">
        <property type="nucleotide sequence ID" value="XM_002479461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M672"/>
    <dbReference type="GeneID" id="8109587"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_024050"/>
    <dbReference type="eggNOG" id="ENOG502SY5H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162840_0_0_1"/>
    <dbReference type="InParanoid" id="B8M672"/>
    <dbReference type="OMA" id="STAVHMD"/>
    <dbReference type="OrthoDB" id="5353310at2759"/>
    <dbReference type="PhylomeDB" id="B8M672"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="120" mass="13630" checksum="50D095C3C9639B19" modified="2009-03-03" version="1">MQQSNLSQVSFPGREPDSPVTLTNLTITNSIKSDVSLVKDPEFWRRFSVAIHQDEEQARQPEREKTEGESWLARQRKKNRRSKICGFLIAFIIALIACGAGIGIWLLSKNGWFKKGTHTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8M679</accession>
    <name>B8M679_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_024120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFI6/IFI27 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479513.1">
        <property type="nucleotide sequence ID" value="XM_002479468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M679"/>
    <dbReference type="GeneID" id="8109594"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_024120"/>
    <dbReference type="eggNOG" id="ENOG502SCCP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1876818_0_0_1"/>
    <dbReference type="InParanoid" id="B8M679"/>
    <dbReference type="OMA" id="TWFMGRN"/>
    <dbReference type="OrthoDB" id="440424at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009311">
        <property type="entry name" value="IFI6/IFI27-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038213">
        <property type="entry name" value="IFI6/IFI27-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16932">
        <property type="entry name" value="INTERFERON ALPHA-INDUCIBLE PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16932:SF18">
        <property type="entry name" value="INTERFERON, ALPHA-INDUCIBLE PROTEIN 27-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06140">
        <property type="entry name" value="Ifi-6-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED19079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="136" mass="13051" checksum="5A70FDE93E0CDE16" modified="2009-03-03" version="1">MLFDSNTAKEVVKGLLQSATQFIRENPALTAWAVAATSGAALLAAPGAAAALLLNFAGFTGTGVQSGSLAAAAHSIIGNVAAGSMFSFLQSAGAGGAAALGTINGVIQAAGAAMFGSGAGMTYLKSNVSNSTTNGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8M690</accession>
    <name>B8M690_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pogo transposable element, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_025810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479699.1">
        <property type="nucleotide sequence ID" value="XM_002479654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M690"/>
    <dbReference type="GeneID" id="8107993"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_025810"/>
    <dbReference type="eggNOG" id="ENOG502S2ZX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_4_0_1"/>
    <dbReference type="InParanoid" id="B8M690"/>
    <dbReference type="OMA" id="CSEVENC"/>
    <dbReference type="OrthoDB" id="4217853at2759"/>
    <dbReference type="PhylomeDB" id="B8M690"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="60"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED19265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="548" mass="62844" checksum="19CC5741DF32D6D3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6B0</accession>
    <name>B8M6B0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multiple myeloma tumor-associated protein 2-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_026000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479719.1">
        <property type="nucleotide sequence ID" value="XM_002479674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6B0"/>
    <dbReference type="GeneID" id="8108012"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_026000"/>
    <dbReference type="eggNOG" id="KOG4520">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061193_3_0_1"/>
    <dbReference type="InParanoid" id="B8M6B0"/>
    <dbReference type="OMA" id="THHRVDR"/>
    <dbReference type="OrthoDB" id="5390672at2759"/>
    <dbReference type="PhylomeDB" id="B8M6B0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019315">
        <property type="entry name" value="MMTA2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039207">
        <property type="entry name" value="MMTAG2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580:SF0">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10159">
        <property type="entry name" value="MMtag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Multiple myeloma tumor-associated protein 2-like N-terminal" evidence="3">
        <location>
            <begin position="11"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED19285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="288" mass="33153" checksum="82C17F7C33C30826" modified="2009-03-03" version="1">MDLVAGVRKEGSRGGRDSFKWSDVKESSHRENYLGHSIMAPVGRWQQGRDLNWYAKNNQDSDAAKQEHEEEIRRIKEAEQDAMALALGLPVAPRSAASNANMTPLGGNDVRKAVQESTETEDRTGDDGGRGIGFGSYGGVAGSMNETDGETLAPIGMDSAGDRLSVREKDGGRGRESRCHRSRRDRSREHGRKRERGHRDHGRSHRHDRDLDREHLHRHHHREHREHRRHRSRSRSGSRSPRPERRDRRHESGRRRDADRSGRRRSSSPRHDRAGRENDREAHRHHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6D7</accession>
    <name>B8M6D7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine palmitoyltransferase small subunit A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_026230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479746.1">
        <property type="nucleotide sequence ID" value="XM_002479701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6D7"/>
    <dbReference type="STRING" id="441959.B8M6D7"/>
    <dbReference type="GeneID" id="8098904"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_026230"/>
    <dbReference type="eggNOG" id="ENOG502S8DA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122021_1_0_1"/>
    <dbReference type="InParanoid" id="B8M6D7"/>
    <dbReference type="OMA" id="VISRAWY"/>
    <dbReference type="OrthoDB" id="202672at2759"/>
    <dbReference type="PhylomeDB" id="B8M6D7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024512">
        <property type="entry name" value="Ser_palmitoyltrfase_ssu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11779">
        <property type="entry name" value="SPT_ssu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED19312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14128" checksum="896AC3F5C9D1F52C" modified="2009-03-03" version="1">MSPPSMASSPSPSVFTSLLRWLRLKIYQYEVTFALYMLTPTEKFIFNSLVLAFLSLFITAAYIYLPDHVASIYGHVHYYFTADVSMIKEYIPSPSSILQGSSAGPATGALNVVYESIQGAASTAGLDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7S1</accession>
    <name>B8M7S1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit TIM23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_030660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480234.1">
        <property type="nucleotide sequence ID" value="XM_002480189.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480235.1">
        <property type="nucleotide sequence ID" value="XM_002480190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7S1"/>
    <dbReference type="FunCoup" id="B8M7S1">
        <property type="interactions" value="567"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M7S1"/>
    <dbReference type="GeneID" id="8101745"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_030660"/>
    <dbReference type="eggNOG" id="KOG3324">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063935_1_1_1"/>
    <dbReference type="InParanoid" id="B8M7S1"/>
    <dbReference type="OMA" id="FQPTPFD"/>
    <dbReference type="OrthoDB" id="159299at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005681">
        <property type="entry name" value="Tim23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00983">
        <property type="entry name" value="3a0801s02tim23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF0">
        <property type="entry name" value="SD19278P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED19800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="206" mass="21644" checksum="2C1B9D11ED0B9003" modified="2009-03-03" version="1">MAIWDSFSGRKATTNQDTFDPSSAQDVSSFLGQASFPDPSQLHPLAGLNQDTLDYLTLEDSTLDELPGSRSALPSRGWSDDLCYGTGSTYLAGLLIGGTWGLAEGLQRTPASAPPKLRLNGVLNSITRRGPFLGNSAGVVAMVYNGINSMIGYTRGKHDAANSIVAGALSGMIFKSTRGTRPMLISGGIVASIAGAWTVTRKALFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8C2</accession>
    <name>B8M8C2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_036590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480869.1">
        <property type="nucleotide sequence ID" value="XM_002480824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8C2"/>
    <dbReference type="STRING" id="441959.B8M8C2"/>
    <dbReference type="GeneID" id="8101930"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_036590"/>
    <dbReference type="eggNOG" id="KOG3699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_1_2_1"/>
    <dbReference type="InParanoid" id="B8M8C2"/>
    <dbReference type="OMA" id="LMERSCK"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="PhylomeDB" id="B8M8C2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF25">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 14 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="1">
        <location>
            <begin position="54"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="287" mass="31835" checksum="BA36C6812552CA7A" modified="2009-03-03" version="1">MAPIPTPETTAQPILKSNETKDVDVMAAMAHNGKALPGIPTFNSFIEKRQWQLEHMAGAFRVFARDGFAEGISGHISVRDPEFQDRFWINPLAVHFGMVKASDMICVNLDGEVVGGNTAGSINAAGFQIHSSIHRSRSDVHAICHTHSVHGRAWSAFARPLEMINQDVCYFYKAHSVYSDYGGIANEASEGQRIAQSLGDGKAVILMNHGLLTVGQTVDEAAFLFCLMERSCKVQLLAERTGLEKRIVSDEEAAYNYKMASTPETLFVEFQPHYQYEEYLSKGDFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8E8</accession>
    <name>B8M8E8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">High osmolarity glycerol pathway protein Nbp2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_036820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480895.1">
        <property type="nucleotide sequence ID" value="XM_002480850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8E8"/>
    <dbReference type="GeneID" id="8100528"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_036820"/>
    <dbReference type="eggNOG" id="ENOG502RZ32">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024803_2_0_1"/>
    <dbReference type="InParanoid" id="B8M8E8"/>
    <dbReference type="OMA" id="RGYYMGT"/>
    <dbReference type="OrthoDB" id="19092at2759"/>
    <dbReference type="PhylomeDB" id="B8M8E8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="294"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="100"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="364"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED20461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="412" mass="44189" checksum="BA950C874F421C9F" modified="2009-03-03" version="1">MATATTTSPQLNATGSRAVNPALPPVATDTPSRLPPMRRISSSARERLSVYSNVSQTSQHRSRPVSHVFPLFHSSLPYTLVRDFAYPPIHPLHYGPLPVPSRASTPASESRRLSDPQIGLWEPSRHSWSSNSGASDSHGQQLPAVSFGDGPPYSEDEDLHSPIITSRYRKHKSVHTFGDTGRGFGDSGRAGGVLNSQSDRGTLVAVNGDGSETYYVQGDQDASDGPGGEYITYPAGESSYSQYAYGNYGGTGVGAGGEGTQGSGHDGGDYVYEDDYSDRYSRDYHFSIGSPDEEMHGKAVALFDFTREHENELPLKEGQVILVSYRHGQGWLVAEDPRTGESGLVPEEFVRLVRDIEGGLSSLNGALSSGPNEAQSNNTITTGSSNTAGETTPTNGNNQGEILEERTEEKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8R3</accession>
    <name>B8M8R3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-tubulin suppressor protein Aats1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_037900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481010.1">
        <property type="nucleotide sequence ID" value="XM_002480965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8R3"/>
    <dbReference type="FunCoup" id="B8M8R3">
        <property type="interactions" value="100"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M8R3"/>
    <dbReference type="GeneID" id="8102166"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_037900"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005210_0_0_1"/>
    <dbReference type="InParanoid" id="B8M8R3"/>
    <dbReference type="OMA" id="GWGNCRK"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="PhylomeDB" id="B8M8R3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF5">
        <property type="entry name" value="RCC DOMAIN-CONTAINING PROTEIN ATS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="41"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="4">
        <location>
            <begin position="43"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="195"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="263"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="386"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED20576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="493" mass="53862" checksum="B87F969731D0E247" modified="2009-03-03" version="1">MDQPMMAFLMGIVLTDKQSIDKAPSRDDNKSLGEKKEREMQKIFALGSNGSGQLGIGHRDDVSVPTECLFDEDTKTSNENSITASQGIGEGRERKVKRIVCGGNHTIILLEDGAVYAAGLNDDLRCGVCISSRLERRDQEGSEKEDGILRRFRRVKFRRRSTGAVIDRFKDVCATWSATCFIAVTSSSNNTCEKDVVIPLGSGDKGELGLGPGRRSTAPASREVDDSIIDTDDYLIPDFPPPNTYIEAIGSGTNHVVAILSNGDVYGWGASRKGQLGTDSELIKNKIVWSPVKIASAELLKEEFMPRSVSCGREFTFMGGYKKNKPLEGGDDSAGYIYTILGVDDKWNIMSAAPSVQTLQKTSQTQKRYDVSTSWHGIYLHNTLDNSVIAWGRNDRGQLGPHQQQEHSLVRWESVAQFMAGSEHTVAVLSDNRTVVSCGWGEHGNCGSDTDDHGNVKGRLSQIRLPDDALHNNEAKVVRVAAGCATSWIVVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2024-01-24" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8Y4</accession>
    <name>B8M8Y4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_111230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481271.1">
        <property type="nucleotide sequence ID" value="XM_002481226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8Y4"/>
    <dbReference type="STRING" id="441959.B8M8Y4"/>
    <dbReference type="GeneID" id="8109803"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_111230"/>
    <dbReference type="eggNOG" id="ENOG502S7QN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1397173_0_0_1"/>
    <dbReference type="InParanoid" id="B8M8Y4"/>
    <dbReference type="PhylomeDB" id="B8M8Y4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED17279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="217" mass="23976" checksum="1C961849FE4B2E48" modified="2009-03-03" version="1">MIKPPTVNVPNRQLLTFLNHQLSIGNWINRELAQPPTVNVLNHQLFNDQRPSWLNRHLAPCSIVNCLLRSANCQLTLPVTGNLLIHQLSTNLAGDWQLAQPSTDNSQLVTNLPNHQLSIGSLAPRPTGQRAHHQRPSWLNRHLANCQLSNGLTAICQLAQSPTVKCLSRRLAPCSIANCQLAQSSTVNCQLSNGSTAIWQLGEPPTVHWLCRQLSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>B8M944</accession>
    <name>B8M944_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_111750</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002481286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M944"/>
    <dbReference type="STRING" id="441959.B8M944"/>
    <dbReference type="GeneID" id="8098830"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_111750"/>
    <dbReference type="eggNOG" id="ENOG502QTEH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011881_1_1_1"/>
    <dbReference type="InParanoid" id="B8M944"/>
    <dbReference type="OMA" id="TSWEIMG"/>
    <dbReference type="OrthoDB" id="25921at2759"/>
    <dbReference type="PhylomeDB" id="B8M944"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF7">
        <property type="entry name" value="PROTEIN STB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED17339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="703" mass="78884" checksum="C79C3C8BD1DDD2BA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9N1</accession>
    <name>B8M9N1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat protein (Yar1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_118050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482025.1">
        <property type="nucleotide sequence ID" value="XM_002481980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9N1"/>
    <dbReference type="FunCoup" id="B8M9N1">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M9N1"/>
    <dbReference type="GeneID" id="8099729"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_118050"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_20_0_1"/>
    <dbReference type="InParanoid" id="B8M9N1"/>
    <dbReference type="OMA" id="THLECVK"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="PhylomeDB" id="B8M9N1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118:SF100">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118">
        <property type="entry name" value="POTE ANKYRIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED18033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="241" mass="26433" checksum="919842F053483C6B" modified="2009-03-03" version="1">MEKSHSSNPPAPVALSFEAIDELIYDARLGDLDALKEELSKWSREHDVPAAAIVRSALDTEDESEGGTGACLLHWPAANGNVELLNYLLQILTDSDAATTLQEFTSFINYRNYTGNTPLHWAALNTHLDCVKALVEAGADIGLKNDAGHDALFLAERADWSGTYDDEDEGKNNDNNEKQEEGNGTTEIEIELNAEQEGKKSDVPPTKARQVVEWLLSCDKGAGFERPVDKQESDAQMEDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9X5</accession>
    <name>B8M9X5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aspartyl protease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_118910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482119.1">
        <property type="nucleotide sequence ID" value="XM_002482074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9X5"/>
    <dbReference type="STRING" id="441959.B8M9X5"/>
    <dbReference type="MEROPS" id="A01.081"/>
    <dbReference type="GeneID" id="8108565"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_118910"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062498_0_0_1"/>
    <dbReference type="InParanoid" id="B8M9X5"/>
    <dbReference type="OMA" id="YILANCI"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="PhylomeDB" id="B8M9X5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF68">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="6"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="260"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED18127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="352" mass="38354" checksum="A3A3DFEFB8F206CF" modified="2009-03-03" version="1">MDIMRRLVQLDLGTPAKTYDLLFDNGSATLWVLSGNCTDQCPNASGHSRTTYNLTSTGEAYYNTTDSIVYDGGKVFGYLVSDIAEVPGTNVPFCQKFASITSSTWAALGADGFLGLASSTIAFPNTTAPFENAIQLGLLDQPRFAIYQGTGIPTVANPSPENNGVLTMGGSHEDVYADGEVEFVPINTPFQVYKAQFQGVSGSNHFANQNEQHGSLKWDGDVVFDTGSGLINLPESHIAAVYNMAPWSYGQLMTGYRPLCSDFNNTWSLSFTFGTDDTHKTFTLSGDQLATPGYVDDDHCFPPFNSWGSNNTILGARWMSNFYSVFDFGSFEPLGYDLRIGFAPLKEYQPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9Z4</accession>
    <name>B8M9Z4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_119100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482138.1">
        <property type="nucleotide sequence ID" value="XM_002482093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9Z4"/>
    <dbReference type="STRING" id="441959.B8M9Z4"/>
    <dbReference type="GeneID" id="8104360"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119100"/>
    <dbReference type="eggNOG" id="ENOG502RXEV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014019_1_0_1"/>
    <dbReference type="InParanoid" id="B8M9Z4"/>
    <dbReference type="OMA" id="GNWTMSD"/>
    <dbReference type="OrthoDB" id="648861at2759"/>
    <dbReference type="PhylomeDB" id="B8M9Z4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED18146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="648" mass="73158" checksum="7B8492D6FC8C3AFA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8MA49</accession>
    <name>B8MA49_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_121220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482370.1">
        <property type="nucleotide sequence ID" value="XM_002482325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MA49"/>
    <dbReference type="STRING" id="441959.B8MA49"/>
    <dbReference type="GeneID" id="8099362"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_121220"/>
    <dbReference type="eggNOG" id="ENOG502S366">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029869_0_0_1"/>
    <dbReference type="InParanoid" id="B8MA49"/>
    <dbReference type="OMA" id="CHWQYLA"/>
    <dbReference type="OrthoDB" id="6058203at2759"/>
    <dbReference type="PhylomeDB" id="B8MA49"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="2"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED18378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="628" mass="70916" checksum="860058D46558CFD4" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBS6</accession>
    <name>B8MBS6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonucleases P/MRP subunit Pop8-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_119690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482201.1">
        <property type="nucleotide sequence ID" value="XM_002482156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBS6"/>
    <dbReference type="STRING" id="441959.B8MBS6"/>
    <dbReference type="GeneID" id="8105244"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119690"/>
    <dbReference type="eggNOG" id="ENOG502SCWV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115053_1_1_1"/>
    <dbReference type="InParanoid" id="B8MBS6"/>
    <dbReference type="OMA" id="QVKSYCT"/>
    <dbReference type="OrthoDB" id="5530243at2759"/>
    <dbReference type="PhylomeDB" id="B8MBS6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000294">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020347">
        <property type="entry name" value="Pop8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049128">
        <property type="entry name" value="Pop8-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28173">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28173:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20976">
        <property type="entry name" value="Pop8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonucleases P/MRP subunit Pop8-like" evidence="2">
        <location>
            <begin position="33"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED18209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="180" mass="19231" checksum="FD8372AFE08C026E" modified="2009-03-03" version="1">MASQTEDVIMTAEHTTTTNNKSTQRRITSRNPQWTYFKLQLIPHSNHPIKNFTIDPLTARAHLSSALSQFLGLMGTSIGIDILKIENPSSSSTVQQQQSAKRPIIEFPNVWIRVPKDDGAAVLAALSSWVGSLSSSAAAAAAAAGDVSEDGDGGVAWRVCAKGNYLNAIVHGSGKEVFDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8MC23</accession>
    <name>B8MC23_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_122050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
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        <property type="entry name" value="adh_short_C2"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED18469.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
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    </evidence>
    <sequence length="239" mass="26354" checksum="C51FF667C8D05AFB" modified="2009-03-03" version="1">MGEAMAQHFLQEEANGSYCALTVTNTEFDEFDKSVPAKNSARAVGAALDVGDKQAVVEWVKISAKRLRRIDVVIANASPMHMEGETEHWQSSFAIDVMGFVDLVKAKIPYLEKSSQASIIVQSSFMGREFYRSPPAAYGPCKAAQLQHVQKLSHFLGPKKIRVNAISPGPILCKGGPWGKYSEIMPEWVEEQRSKVPLKRLGAPEEIEKVAVFLASPLDSFFTGANVFVNGRIHIGTQF</sequence>
</entry>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
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    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
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    </reference>
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        <subcellularLocation>
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        <subcellularLocation>
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    </dbReference>
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        <property type="term" value="C:Golgi stack"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:intracellular signal transduction"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:regulation of actomyosin contractile ring contraction"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of division septum assembly"/>
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        <property type="entry name" value="BAR_DNMBP"/>
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    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="1393"/>
        </location>
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        <location>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <property type="taxonomic scope" value="Eukaryota"/>
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            <begin position="1"/>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED17589.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="36449" checksum="43B44415D00AC8C9" modified="2009-03-03" version="1">MEVLQNSPSASSFTPLAEHQSRTPQSFYGGPPVLHYHSSRCKVVILESDISASPALNTLRGGAPVANGSSEVAPEPQEGKEIVIDGVDVFVTSDKFLLYRTEANSGIALPYPLISLHAIQRLRLPDTPENEQEGQGLYMQIAKPTPADGTGAEEDEEEDSITLTIVPPSVTEAASSALGSYSAGTEMTGLVAEEMAAEQGNAEAKPEETATQALYAAVSACSNLHPDPVAPGEEGDDDYYGNYEDSTEQPGVGGILQAAGLIVPGASDGGLPPPVDGSSGWITAENMHEYFDEEGNWIADGEPPASMTLPGLGPGAGNVHGRNDGDQVENGDGAGEKNGDGETKWRRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDD5</accession>
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    </protein>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17898.1"/>
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    </dbReference>
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        <property type="entry name" value="MRX11"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF10306">
        <property type="entry name" value="FLILHELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED17898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="209" mass="23332" checksum="9851505B6CBE53C3" modified="2009-03-03" version="1">MIFSRLFPRPSINPKLHIIRRFSLQRRLLNSASPDRAPEPSSSLRARLQKFNDRLPRFLRGYTTPLIGAPTTHITSFLVLHEITAVLPLFGLFGFFHYSGWTPLLSAGDNDTLNEAVQRFGKWMTKKGWVGSEDVEAAKNVSSCTPSADDQVLTQQKGAQLVLQFAAAYVTTKALLPLRIVASVWATPWFARVLLGPIGRGIKGIFQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDS8</accession>
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        <lineage>
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        </lineage>
    </organism>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED18307.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="441959.B8MDS8"/>
    <dbReference type="GeneID" id="8100039"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_120550"/>
    <dbReference type="eggNOG" id="ENOG502REZ6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061220_0_0_1"/>
    <dbReference type="InParanoid" id="B8MDS8"/>
    <dbReference type="OMA" id="IWSILVY"/>
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    <dbReference type="PhylomeDB" id="B8MDS8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013920">
        <property type="entry name" value="DUF1774_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992:SF1">
        <property type="entry name" value="DUF1774-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08611">
        <property type="entry name" value="DUF1774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32741" checksum="799B9D2F1A702CFD" modified="2009-03-03" version="1">MANFNPFARRESHHRNTLIAYQVLSVLSWALVLVAGIYYSLHKPDDVKHGHNIWKQANRHPTPFSQNTTITGIYWILLLLSQVSYVWHFFSNNGTLVTSAANVASHFILNNLLVFAFIMLWVRNYFWPAEIILIIHVISQSSAYWTHRGSPPFVHWPAIAGPYAWSLTALFWNGAVAVHAHNLPSRIVANIFIWVIFLIGFVHIFTAKDYIFGYSLSILTLSLAVEQLAIKIIALQWIFAFVIFAVFFVGSLYVSSAAYTGRDLWLKRVVAPDSTTDREREPLLNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDY2</accession>
    <name>B8MDY2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase Rpb1 C-terminal repeat domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_011680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483293.1">
        <property type="nucleotide sequence ID" value="XM_002483248.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MDY2"/>
    <dbReference type="GeneID" id="8105474"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_011680"/>
    <dbReference type="eggNOG" id="ENOG502S3YY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005288_1_0_1"/>
    <dbReference type="InParanoid" id="B8MDY2"/>
    <dbReference type="OMA" id="THEANAK"/>
    <dbReference type="OrthoDB" id="6365728at2759"/>
    <dbReference type="PhylomeDB" id="B8MDY2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038799">
        <property type="entry name" value="LEKR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34251:SF1">
        <property type="entry name" value="LEUCINE, GLUTAMATE AND LYSINE RICH 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34251">
        <property type="entry name" value="LEUCINE-, GLUTAMATE- AND LYSINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="614"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1361"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="664"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="731"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
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            <end position="221"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
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        </location>
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        </location>
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            <begin position="410"/>
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        </location>
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        <location>
            <begin position="441"/>
            <end position="470"/>
        </location>
    </feature>
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        <location>
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            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1372"/>
            <end position="1390"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED16059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1390" mass="156290" checksum="F2DD23E6CE969B52" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDY9</accession>
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        <submittedName>
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        </submittedName>
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    </gene>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    <dbReference type="GeneID" id="8105476"/>
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    <dbReference type="eggNOG" id="KOG0039">
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    </dbReference>
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    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="PhylomeDB" id="B8MDY9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
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        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED16066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="292" mass="34256" checksum="4E7201609531458A" modified="2009-03-03" version="1">MLTSILIIRRQVYDLSLVTHVILAVIFVVGCWYHIQFEYGFTFGYETWLYTAIAVWFFDRLIRLLRLLKAGLHYAKIVRIDIPGLRWAIMPCHRVHVHFPPIHPWRACENHPFSIIPTSILSPQQQHAQEQNSDAEGRLDEKARKAIHITSDEDSQNRLSTNGFYINTGVTIFVRKGQDMTSYLKPCERLLTLVDGPYRCSANQGVLRSDHLLLIGGGIRITGLLSFLNPRQRIVKLYYSLKRELLMDARMRFESFTRMLSQNPIPSRYAMTDEIARNQLRTVHRWWRNFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEE7</accession>
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        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">TSTA_016510</name>
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    <organism evidence="7 8">
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002483763.1"/>
    </dbReference>
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        <property type="interactions" value="73"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MEE7"/>
    <dbReference type="GeneID" id="8106424"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_016510"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018202_0_1_1"/>
    <dbReference type="InParanoid" id="B8MEE7"/>
    <dbReference type="OMA" id="QFCAGEK"/>
    <dbReference type="OrthoDB" id="5464at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
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        <property type="entry name" value="PROLINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED16574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="552" mass="61997" checksum="172F5896AEBE90EF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8MF61</accession>
    <name>B8MF61_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell agglutination protein mam3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_012670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483394.1">
        <property type="nucleotide sequence ID" value="XM_002483349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MF61"/>
    <dbReference type="STRING" id="441959.B8MF61"/>
    <dbReference type="GeneID" id="8108143"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_012670"/>
    <dbReference type="HOGENOM" id="CLU_423995_0_0_1"/>
    <dbReference type="InParanoid" id="B8MF61"/>
    <dbReference type="OMA" id="YNIMPNF"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877701" evidence="2">
        <location>
            <begin position="22"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="526"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED16160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="646" mass="62415" checksum="2893661ABF028BB6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFL6</accession>
    <name>B8MFL6_TALSN</name>
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        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="10" type="ORF">TSTA_020630</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484240.1">
        <property type="nucleotide sequence ID" value="XM_002484195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFL6"/>
    <dbReference type="STRING" id="441959.B8MFL6"/>
    <dbReference type="GeneID" id="8102457"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_020630"/>
    <dbReference type="HOGENOM" id="CLU_399062_0_0_1"/>
    <dbReference type="InParanoid" id="B8MFL6"/>
    <dbReference type="OMA" id="SMEQGWI"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="PhylomeDB" id="B8MFL6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF78">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED17006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="757" mass="85086" checksum="A399A492220EE7DA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFN5</accession>
    <name>B8MFN5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Exportin-T</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exportin(tRNA)</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA exportin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_020810</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <text evidence="11">Shuttles between the nucleus and the cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484259.1">
        <property type="nucleotide sequence ID" value="XM_002484214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFN5"/>
    <dbReference type="FunCoup" id="B8MFN5">
        <property type="interactions" value="1041"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MFN5"/>
    <dbReference type="GeneID" id="8109343"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_020810"/>
    <dbReference type="eggNOG" id="KOG2021">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004414_0_1_1"/>
    <dbReference type="InParanoid" id="B8MFN5"/>
    <dbReference type="OMA" id="HEMFLFG"/>
    <dbReference type="OrthoDB" id="26399at2759"/>
    <dbReference type="PhylomeDB" id="B8MFN5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000355">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045546">
        <property type="entry name" value="Exportin-T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040017">
        <property type="entry name" value="XPOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952:SF11">
        <property type="entry name" value="EXPORTIN-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952">
        <property type="entry name" value="EXPORTIN-T/LOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19282">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="6 11" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="12">
        <location>
            <begin position="104"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-T C-terminal" evidence="13">
        <location>
            <begin position="344"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED17025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1023" mass="114481" checksum="D523FD037C4FCFF7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFP8</accession>
    <name>B8MFP8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_020960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484272.1">
        <property type="nucleotide sequence ID" value="XM_002484227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFP8"/>
    <dbReference type="STRING" id="441959.B8MFP8"/>
    <dbReference type="GeneID" id="8109356"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_020960"/>
    <dbReference type="HOGENOM" id="CLU_1403284_0_0_1"/>
    <dbReference type="InParanoid" id="B8MFP8"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="PhylomeDB" id="B8MFP8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24134:SF9">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24134">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN DDB_G0279043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED17038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="194" mass="22104" checksum="B719284F8352120C" modified="2009-03-03" version="1">MDGLTIDLDKLRKANSDYYGENIWRLLIVSGSSGESESDSDEENFWRQGQSQSDLSERNNSKNDDEWDKGTEHCVEVLSLLLENCNHDISVNAKDKQGLPALHIGSIARDSAIVEKLLNDVRDIEFNAKNSYVWTPLHKAAFYRYRIETVKALRENGRNIDWSLKDGKQRTAVELANGHGLLKNNLVEHEKFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFQ4</accession>
    <name>B8MFQ4_TALSN</name>
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        <submittedName>
            <fullName evidence="3">HLH transcription factor (PalcA), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_021050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484278.1">
        <property type="nucleotide sequence ID" value="XM_002484233.1"/>
    </dbReference>
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    <dbReference type="STRING" id="441959.B8MFQ4"/>
    <dbReference type="GeneID" id="8109362"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_021050"/>
    <dbReference type="eggNOG" id="ENOG502S7T4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015973_0_0_1"/>
    <dbReference type="InParanoid" id="B8MFQ4"/>
    <dbReference type="OMA" id="EQDMAFT"/>
    <dbReference type="OrthoDB" id="5344169at2759"/>
    <dbReference type="PhylomeDB" id="B8MFQ4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11392">
        <property type="entry name" value="bHLH_ScPHO4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="590"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="681"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="308"/>
        </location>
    </feature>
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        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED17044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="718" mass="78253" checksum="15B73A91367CDD54" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGC4</accession>
    <name>B8MGC4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">TSTA_013470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483478.1">
        <property type="nucleotide sequence ID" value="XM_002483433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGC4"/>
    <dbReference type="GeneID" id="8099146"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_013470"/>
    <dbReference type="eggNOG" id="ENOG502RS48">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032663_0_0_1"/>
    <dbReference type="InParanoid" id="B8MGC4"/>
    <dbReference type="OMA" id="WEEPYLE"/>
    <dbReference type="OrthoDB" id="5427059at2759"/>
    <dbReference type="PhylomeDB" id="B8MGC4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="445" mass="52082" checksum="069E1F276D083B0C" modified="2009-03-03" version="1">MPNLKSIRTLILASSKYYETYKKFRSQVLYDLLLRQHNDEVDITEAVVAMRSEGVLAEDIRNREMIFELLDCRRRGSKERKTKFNHASFTVNEILKMVEMHQAAEYFLEDYAVSIPVPVWWDHKSRQWKTPISFSHTERARFFRAFYRLQTWCHIFGQPEYRCSSASSSSSSSSSSSSSSSSASPFSAGLGRQSENEWTDRTFTHEQAWRMIWGTMPPWEIEEVGCLLDYFMLKYIHIFQDITAALINRYHPGNSAEEEDDNPDPSSPNSFSRGTPTPAVGTEPLRSIHISYELDGDPWSLARTFRYSMIEIGPCFLYKILQQPYDERHVAVSHNLRSVFTTKLWEVTGLNDEQKLPLVSPADKYEREGLATVISSWHVLDRPNKAWIRHWAGLEGQLHPRLWLGGEFSLYSSYPTMHRREWKWGYVLWDDERLDEWKAYLSTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGT7</accession>
    <name>B8MGT7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_014140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483552.1">
        <property type="nucleotide sequence ID" value="XM_002483507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGT7"/>
    <dbReference type="STRING" id="441959.B8MGT7"/>
    <dbReference type="GeneID" id="8099213"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_014140"/>
    <dbReference type="HOGENOM" id="CLU_1171289_0_0_1"/>
    <dbReference type="InParanoid" id="B8MGT7"/>
    <dbReference type="OrthoDB" id="5243754at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED16318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="237" mass="26686" checksum="41247BD07127F044" modified="2009-03-03" version="1">MRLRRLDGKAADLLCWLSLICTGNYRKPYPSSRRRRLRYRGDDPRKLFTTTVAPVTDYTSEIGGIAATGAFRTVATAVVEAEANICSFGERHIEKSTKLWADIRALPRTNPLNEAESHINSKAFLSTTYTDTRKRALPVKHTHDLYDRLKRKEAMALAQLRMGMTRLNSYPNKTGAAESDLCACKQCIEMRRGSLSFYLGGKARSDPEQWRPDIKAPLSWSINLNSLGVKNPSSMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGW1</accession>
    <name>B8MGW1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_014330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483576.1">
        <property type="nucleotide sequence ID" value="XM_002483531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGW1"/>
    <dbReference type="STRING" id="441959.B8MGW1"/>
    <dbReference type="GeneID" id="8107816"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_014330"/>
    <dbReference type="eggNOG" id="ENOG502STJP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_276095_0_0_1"/>
    <dbReference type="InParanoid" id="B8MGW1"/>
    <dbReference type="OMA" id="YEDFFCS"/>
    <dbReference type="OrthoDB" id="3538943at2759"/>
    <dbReference type="PhylomeDB" id="B8MGW1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="240"/>
        </location>
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            <end position="729"/>
        </location>
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        <location>
            <begin position="926"/>
            <end position="967"/>
        </location>
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            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
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            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
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        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
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            <begin position="210"/>
            <end position="220"/>
        </location>
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            <begin position="343"/>
            <end position="358"/>
        </location>
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        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
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        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
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            <begin position="501"/>
            <end position="521"/>
        </location>
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        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
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            <end position="596"/>
        </location>
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        <location>
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            <end position="628"/>
        </location>
    </feature>
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        <location>
            <begin position="653"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1136" mass="126989" checksum="03730911A6D224B9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGW9</accession>
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        <recommendedName>
            <fullName evidence="2">Inner kinetochore subunit AME1 domain-containing protein</fullName>
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    </protein>
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    </gene>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483584.1">
        <property type="nucleotide sequence ID" value="XM_002483539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGW9"/>
    <dbReference type="STRING" id="441959.B8MGW9"/>
    <dbReference type="GeneID" id="8107824"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_014410"/>
    <dbReference type="eggNOG" id="ENOG502SGUR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013782_1_0_1"/>
    <dbReference type="InParanoid" id="B8MGW9"/>
    <dbReference type="OMA" id="SVMRIKG"/>
    <dbReference type="OrthoDB" id="5377952at2759"/>
    <dbReference type="PhylomeDB" id="B8MGW9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048743">
        <property type="entry name" value="AME1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20994">
        <property type="entry name" value="CENPU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="429"/>
            <end position="666"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="434"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="31"/>
            <end position="47"/>
        </location>
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            <begin position="53"/>
            <end position="72"/>
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    </feature>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20994"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED16350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="678" mass="75473" checksum="68CAC8CADEA872AB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHK4</accession>
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        <name evidence="3" type="ORF">TSTA_011010</name>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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        </lineage>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002483174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHK4"/>
    <dbReference type="STRING" id="441959.B8MHK4"/>
    <dbReference type="GeneID" id="8109874"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_011010"/>
    <dbReference type="eggNOG" id="KOG3857">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_915792_0_0_1"/>
    <dbReference type="InParanoid" id="B8MHK4"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="PhylomeDB" id="B8MHK4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
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        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF107">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06800)-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="33"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED15985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="304" mass="33028" checksum="07998F4C976DCC70" modified="2009-03-03" version="1">MVVMPVPALIVLTPNFSIDGVYSKVHVYMALRTNPYLNQLEAALGDNHAGTWIGIRPHTFWDDLVPIVNDIRAKKVDIVVTLGGTSIVDGAKAITYALANNVRPVEDMRTIVNPSPDDIARQDKFLQRDGIGNAPTVPLIFIPTSLSGGEYFKFSGAPTHNEGCLPHGIGYQLGPLGVGRGHTSCIMLPAVMKWNVARASEAQNDILGQQEKLKRVFLAEESVTSVLREANIDVKTCDVGDILRAVFNKLRMPATLEVGVGRDRFGTLARNSLNDAFLPTNPVPLLEKDVDKVLEILELVAGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHS9</accession>
    <name>B8MHS9_TALSN</name>
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        <submittedName>
            <fullName evidence="5">Anterior fat body protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_014980</name>
    </gene>
    <organism evidence="5 6">
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        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483642.1">
        <property type="nucleotide sequence ID" value="XM_002483597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHS9"/>
    <dbReference type="FunCoup" id="B8MHS9">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MHS9"/>
    <dbReference type="GeneID" id="8106240"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_014980"/>
    <dbReference type="eggNOG" id="KOG4499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036110_3_0_1"/>
    <dbReference type="InParanoid" id="B8MHS9"/>
    <dbReference type="OMA" id="LWRCRAD"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="PhylomeDB" id="B8MHS9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF47">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="4">
        <location>
            <begin position="17"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED16408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="308" mass="34550" checksum="388E37B02EA9D3AC" modified="2009-03-03" version="1">MQRFTITEPFLDVKCGLSEGPFYEEANNTLRFVDIVKKHVWWVDLNKGPSSAKKIEYDIPFGVTANLSSSTDTFLFGGKHGIGMATRDSREYKYIERFWNEAEISRNYETIMRANDGVIDCHGRFWVGAMNDPAFTNGKFDPVGILFRLDTDGTLHRVLENVTIPNGMSFSLDDKTMYWTDTPTGNIYAFDYDASTGNISNQRVFWHTDLGGGPDGHAMDAEGNLWVAIWGGWKVVRVSPEGKVTAEIEVPTRCPTAVAFVGEDVYITSEEDPEAEKYPESAKWHGGVFKCHVGVKGRRLYDAKIASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHX1</accession>
    <name>B8MHX1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_015380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483685.1">
        <property type="nucleotide sequence ID" value="XM_002483640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHX1"/>
    <dbReference type="STRING" id="441959.B8MHX1"/>
    <dbReference type="GeneID" id="8106280"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_015380"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="InParanoid" id="B8MHX1"/>
    <dbReference type="OMA" id="KDANTMF"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="PhylomeDB" id="B8MHX1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000245">
        <property type="entry name" value="Short chain dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED16451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="293" mass="31748" checksum="0FD37CB6A89EB0B5" modified="2009-03-03" version="1">MSLNIETVATPQKTVRGPAELSDASSVYLGTKNRMPEFVLTDKVVCVSGAGRGLGLVQAEALLEAGAIVYALDRLPEPSEDFARIQAKATTLGTKIEYRCIDVRDTELLNNVIEEIANVEGRMDGLIAAAGIQQETPALEYTAKDANTMMEVNVTGVFMTAQAVAKQMIRFGNGGSIVMIASMSGTIANKGLICPAYNASKAAVIQLGRNLAAEWGQYNIRVNTISPGYIVTQMVENLFVQYPERREEWPKQNMLGRLSRPEEYRGAAVFLISDASSFMTGSDLRMDGGHAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MI29</accession>
    <name>B8MI29_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_022450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484425.1">
        <property type="nucleotide sequence ID" value="XM_002484380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MI29"/>
    <dbReference type="STRING" id="441959.B8MI29"/>
    <dbReference type="GeneID" id="8107082"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_022450"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001324_9_1_1"/>
    <dbReference type="InParanoid" id="B8MI29"/>
    <dbReference type="OMA" id="IRDEMAY"/>
    <dbReference type="OrthoDB" id="4360910at2759"/>
    <dbReference type="PhylomeDB" id="B8MI29"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF95">
        <property type="entry name" value="HELITRON HELICASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="64"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED17191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="207" mass="23232" checksum="E07313B22DB2DB07" modified="2009-03-03" version="1">MVYLAECGLGGTGMVIVDRQRRNEFELLKRQAFSEPAYICDSAVDELTAREDLQEMAERMRQSFNDDQRAAFDRIVTSLENPGSNYSNFYIQGPGGIGKTFLYRALYLYFVGRGKTVFCIASSGIAALLLPNGCIAHSQFRIPLDTKEHSVCDIKVQSQLAQQLRQANLIVWDKVPMTSRYIFEAVDCTLRDVTKSEDSLFGGIAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIN2</accession>
    <name>B8MIN2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA binding protein Nrd1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_045810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485077.1">
        <property type="nucleotide sequence ID" value="XM_002485032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIN2"/>
    <dbReference type="FunCoup" id="B8MIN2">
        <property type="interactions" value="244"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MIN2"/>
    <dbReference type="GeneID" id="8107568"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_045810"/>
    <dbReference type="eggNOG" id="KOG0132">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016577_0_0_1"/>
    <dbReference type="InParanoid" id="B8MIN2"/>
    <dbReference type="OMA" id="GIVQTCI"/>
    <dbReference type="OrthoDB" id="79367at2759"/>
    <dbReference type="PhylomeDB" id="B8MIN2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031126">
        <property type="term" value="P:sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16984">
        <property type="entry name" value="CID_Nrd1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000026">
        <property type="entry name" value="RNA binding protein Nrd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000397">
        <property type="entry name" value="RNA binding protein Nrd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048892">
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    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN CBR-NRD-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21380">
        <property type="entry name" value="Nrd1-Seb1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
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    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
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        <location>
            <begin position="482"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="153"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="205"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="354"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="610"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="689"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="369"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="401"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="636"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="666"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="689"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED15124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="709" mass="75153" checksum="7EBF6D1CB0EEB61C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIX8</accession>
    <name>B8MIX8_TALSN</name>
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        <recommendedName>
            <fullName evidence="4">Electron transfer flavoprotein alpha-subunit</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">TSTA_050780</name>
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    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED15640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="GeneID" id="8109120"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_050780"/>
    <dbReference type="eggNOG" id="KOG1685">
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    </dbReference>
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    <dbReference type="OMA" id="PQRAYKN"/>
    <dbReference type="OrthoDB" id="10251727at2759"/>
    <dbReference type="PhylomeDB" id="B8MIX8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
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        <location>
            <begin position="317"/>
            <end position="388"/>
        </location>
    </feature>
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        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="43242" checksum="CD65826359BA28BB" modified="2009-03-03" version="1">MVAATEVLTTKVASGTPYQLDNKQVLRASSALLRHIKSEQEEKEETSTKKTLIGDDDESDGEGSPATNEIVWLVMTTKKHVVDKNRLKPSKISIPHSLNKSSSLNICLITADPQRSVKDIVADPAFPSDLSARITKVIGLTKLKDRYKSFESRRQLLSEHDVFLADDRIIMRLVETLGKIFYQSSKRPIPIRIEQIEKADGKRVKKDPKAKPSKEERKASFASPQVVAKEIEKALNCAPVYLAPSTTTSVRVGSSKFTPEQLAENVKAVVNGLTEKFISKGWRNVKAIHIKGATTMALPIWLADELWLDETDVLEKEEDEKKAFDNDKSGNKRRNPGDDDSSRGQGKKTKKIKAATDEDDISLKEKLQKRKAQALEEGKAPVKSTKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJH8</accession>
    <name>B8MJH8_TALSN</name>
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        <submittedName>
            <fullName evidence="1">Acetamidase/formamidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_046320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002485086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJH8"/>
    <dbReference type="STRING" id="441959.B8MJH8"/>
    <dbReference type="GeneID" id="8099543"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_046320"/>
    <dbReference type="eggNOG" id="ENOG502SKKH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032013_1_0_1"/>
    <dbReference type="InParanoid" id="B8MJH8"/>
    <dbReference type="OMA" id="GGNMDCR"/>
    <dbReference type="OrthoDB" id="3335528at2759"/>
    <dbReference type="PhylomeDB" id="B8MJH8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.580">
        <property type="entry name" value="Acetamidase/Formamidase-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.20">
        <property type="entry name" value="Acetamidase/Formamidase-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004304">
        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891:SF1">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141130">
        <property type="entry name" value="Acetamidase/Formamidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED15178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="306" mass="32828" checksum="3BB49646E7820FEA" modified="2009-03-03" version="1">MFANGHVHSHHKHLKWSNRQPPVLTVSSGDVVTFDLIDSSNGQITIDSDTSSLNSFQLELADPAVGPVYVRDAEPGDALKVEVLFLEMGNWGWTAVVPGFGLLADDYTQPDLKIWKFDPEAGYAELKPGVRIMGLAPGADGEFSTIPPTVVGGNIDCRDMVAGSALYLPVQVPGALFSCGDGHAAQGHGEVCGTAIETNMKAKIRLTVCKNYPWVQSPHLQLPPQPPAPSAFPDKGHYATMGLDADMLQATRKATRAMVEWLVATKGLTRTEAYILASVAGDLKLAEVVDMPNFAVTMSMPVNIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJW6</accession>
    <name>B8MJW6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyl hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_042570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484736.1">
        <property type="nucleotide sequence ID" value="XM_002484691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJW6"/>
    <dbReference type="STRING" id="441959.B8MJW6"/>
    <dbReference type="GeneID" id="8103350"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_042570"/>
    <dbReference type="eggNOG" id="ENOG502S9QC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028686_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJW6"/>
    <dbReference type="OMA" id="KNAISIW"/>
    <dbReference type="OrthoDB" id="9984024at2759"/>
    <dbReference type="PhylomeDB" id="B8MJW6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF1">
        <property type="entry name" value="ENDO MANNANASE, GH76 FAMILY (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877784" description="Glycosyl hydrolase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="41376" checksum="3D80C39C09AD854F" modified="2009-03-03" version="1">MCVNKKHFGVALLAPSLVTASSMKSLLSKRDASTYEQNAICTAADHISPVRDQLLRSYSVNDTALFGKDLWWQSGNFISALATFYQLDPDYGSIHNDIFAKTLSEAPGYGNYVNFLNGWYDDEGWWGNAFLDVYDYTQDRAYLNQAITIYSDIVGGLGTPCGGIWWDKAKTYVSAISNGLYTELAAGLANRAGDSSYLENAEENWNWFFSSGIVGSDHIVRDGLQSSNGCSLNGNVFTYNQGVILGAAAELYKATGNRTYLTTAAALADASTASGSAVTSSSGILTEGCDKSSNCDTTAQMFKGAYIRGLRKLQLVDPETDWLNYITANAQSIWNNDLNVENVNGQSECIVGSAWAGPFNSDQATVVTQGAALDALNAALATTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B8ML57</accession>
    <name>B8ML57_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_049130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485426.1">
        <property type="nucleotide sequence ID" value="XM_002485381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ML57"/>
    <dbReference type="GeneID" id="8100629"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_049130"/>
    <dbReference type="HOGENOM" id="CLU_1476088_0_0_1"/>
    <dbReference type="InParanoid" id="B8ML57"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED15473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="183" mass="21051" checksum="C29D58299A2C04EF" modified="2009-03-03" version="1">MAIREKYVQASVATILDTILRPPDDEEAAHHFKCTTEDFMEIEKMLMEDGEFERFPRASVYNEENRNAWPRSFMVLELVYTTMEEILGMQKDFICWRGTGMRLFEGCLAGNRKEMETAFCTPESRWFSNICVESGYSQSYDDLVQDVTLLLEGSRGHIGIVILVKLKPLVGEEEAIQNGFVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLE5</accession>
    <name>B8MLE5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">hydroxymethylglutaryl-CoA lyase</fullName>
            <ecNumber evidence="3">4.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_049170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:24404"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="4.1.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="3"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485431.1">
        <property type="nucleotide sequence ID" value="XM_002485386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLE5"/>
    <dbReference type="STRING" id="441959.B8MLE5"/>
    <dbReference type="GeneID" id="8100633"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_049170"/>
    <dbReference type="eggNOG" id="KOG2368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022138_3_0_1"/>
    <dbReference type="InParanoid" id="B8MLE5"/>
    <dbReference type="OMA" id="FQMRNTH"/>
    <dbReference type="OrthoDB" id="1905920at2759"/>
    <dbReference type="PhylomeDB" id="B8MLE5"/>
    <dbReference type="UniPathway" id="UPA00896">
        <property type="reaction ID" value="UER00863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004419">
        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046951">
        <property type="term" value="P:ketone body biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07938">
        <property type="entry name" value="DRE_TIM_HMGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000071">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004283">
        <property type="entry name" value="PRK05692.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738:SF7">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="7">
        <location>
            <begin position="38"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED15478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="362" mass="38554" checksum="AEDCDF3D884C9018" modified="2009-03-03" version="1">MQKFKLSLRVSSALRTAHPRTTPLRSYSTEARLTTDHVRIVEVGPRDGLQNEKKSISLETKLELIRRLANTGVTTIEAGSFVPAKWVPQMASTSEILQHLLRTPPPSQNQIAYNYLVPNIKGLENLVTILESEGATAGSKDDAKASTTTEISLFAAATESFSKANTNCTIAESIERVRPIVALAKEKDIRVRGYVSVALGCPYEGPDVSPGKVAEITATLLEMGADEVSVADTTGMGTAPRTLELLHALSAAGIANSDLALHFHDTYGQALVNTIVGLEHGIRIFDSSVGGLGGCPYSKGATGNVSTEDLVHTLHGLGMHTGIDLEEMSRIGAWISEQLGRANDSRAGKATLARIAGEKTCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLV5</accession>
    <name>B8MLV5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C6 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_101210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486119.1">
        <property type="nucleotide sequence ID" value="XM_002486074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLV5"/>
    <dbReference type="STRING" id="441959.B8MLV5"/>
    <dbReference type="GeneID" id="8101809"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_101210"/>
    <dbReference type="eggNOG" id="ENOG502RXSB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016574_3_1_1"/>
    <dbReference type="InParanoid" id="B8MLV5"/>
    <dbReference type="OMA" id="MIWQLST"/>
    <dbReference type="OrthoDB" id="4132249at2759"/>
    <dbReference type="PhylomeDB" id="B8MLV5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED13881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="506" mass="56366" checksum="9B7E351BCDB84C80" modified="2009-03-03" version="1">MPRQNIVTTACDACRRRKVKCDTQQPCTRCQSAGLVCRTTSVPRKKGRQGATATVLQELRKSPAQTEALSTPSPREYGLGGCFIRSPGLLTPTVIQSCAEYFFARMLGTVPILLPALFQTHVDRMVESLHSYCLVCAFCAFVFTQTGYASWHNPTNPSSALGRSLLEEAMTARRHLDPFTAPSRLGITISFLLYGCQIGMGNQRQAYYFLREATTLYTAGILDQPGTEVDEDPGSLFWLLLISERAHAIRRHRPITLEITPDSPVLDDTHSDAFSVGFRCLADLYRPFNQSFLSHWNGTETSFSRELLIQLEERLRQAVPTDIELPDILLADLRVSQQWLRTMIWQLATTAGFLSSTPSHPCLDFRYPLQIAQELSLATWKLSRESMETHGVDVMACLSHSRLRASGFDLGPQDYLKHLCTLIHGLPGGDTKFLPLLLAKIGQTLPSMLAPLSRHLSLPLTDSAPPEAETVSPVGFGNDWDKDFNWAEMSRIGDKTPELKGTLQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8MM79</accession>
    <name>B8MM79_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_098480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485829.1">
        <property type="nucleotide sequence ID" value="XM_002485784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MM79"/>
    <dbReference type="STRING" id="441959.B8MM79"/>
    <dbReference type="GeneID" id="8099676"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_098480"/>
    <dbReference type="eggNOG" id="ENOG502SY5A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2470607_0_0_1"/>
    <dbReference type="InParanoid" id="B8MM79"/>
    <dbReference type="OMA" id="MFNDALM"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="PhylomeDB" id="B8MM79"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="1">
        <location>
            <begin position="9"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="88" mass="9769" checksum="FB40EF4C0EFCE1E2" modified="2009-03-03" version="1">MFNDALMVGSPNFNDRRLKPGLLTVEEAKKMPPTTFGITGYDPLRDEGLLYAKFLTEQGAPTNVHVFRALPHAFRMLGDKLSASSGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8MM94</accession>
    <name>B8MM94_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ariadne RING finger, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_099030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485886.1">
        <property type="nucleotide sequence ID" value="XM_002485841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MM94"/>
    <dbReference type="STRING" id="441959.B8MM94"/>
    <dbReference type="GeneID" id="8103981"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_099030"/>
    <dbReference type="eggNOG" id="KOG1812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004235_1_0_1"/>
    <dbReference type="InParanoid" id="B8MM94"/>
    <dbReference type="OMA" id="ACHEPHV"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="PhylomeDB" id="B8MM94"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097039">
        <property type="term" value="P:protein linear polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22585">
        <property type="entry name" value="Rcat_RBR_DEAH12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF13">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="406"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED13648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="623" mass="70024" checksum="FE88D0CD5750ED13" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMR8</accession>
    <name>B8MMR8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_100680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486062.1">
        <property type="nucleotide sequence ID" value="XM_002486017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMR8"/>
    <dbReference type="GeneID" id="8097952"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_100680"/>
    <dbReference type="HOGENOM" id="CLU_1636547_0_0_1"/>
    <dbReference type="InParanoid" id="B8MMR8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED13824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="162" mass="17800" checksum="B7A18E6DCAAA33FC" modified="2009-03-03" version="1">MELCSAQDLSYLGVINKDTKFNLNGTGFCDAANATRKYENALAAIAKYHPTSETATALDFAVKAQPHAAHSIPGARANSIDDDITGNLEIGEDPEHFVVHLVSMHKSESGQSRKEWIEELKKIANDKLKEASRVKALLKIIRYAMKPIQVKRLSSTAASYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMS2</accession>
    <name>B8MMS2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_100720</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486066.1">
        <property type="nucleotide sequence ID" value="XM_002486021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMS2"/>
    <dbReference type="FunCoup" id="B8MMS2">
        <property type="interactions" value="1180"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MMS2"/>
    <dbReference type="GeneID" id="8097956"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_100720"/>
    <dbReference type="eggNOG" id="KOG0378">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060400_1_0_1"/>
    <dbReference type="InParanoid" id="B8MMS2"/>
    <dbReference type="OMA" id="GHIQLNL"/>
    <dbReference type="OrthoDB" id="1109245at2759"/>
    <dbReference type="PhylomeDB" id="B8MMS2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_eS4_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003312">
        <property type="entry name" value="PRK04313.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED13828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="263" mass="29549" checksum="A5C12954F0C3D56A" modified="2009-03-03" version="1">MPRGPKKHQKRLSAPAHWLLDKMSGTYAPRASAGPHKLRDCLPLIVFIRNRLKYALNGRETKAILMQRLVQVDGKVRTDPTFPAGFMDVISIEKTGENFRLIYDTKGRFTVHRIQAEEAEYKLGKVKRVQLGKGGIPFLVTHDARTIRYPDPLIKVNDTVKIDLATGKITDFIKFDTGVIAMVTGGRNMGRVGVITHRERHDGGFNIVHIKDAVDNTFATRESNVFVIGQEKPWISLPKGKGVKLSIAEERDRRRAYALAQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B8MN61</accession>
    <name>B8MN61_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_107170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486748.1">
        <property type="nucleotide sequence ID" value="XM_002486703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MN61"/>
    <dbReference type="GeneID" id="8103617"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_107170"/>
    <dbReference type="HOGENOM" id="CLU_058845_0_0_1"/>
    <dbReference type="InParanoid" id="B8MN61"/>
    <dbReference type="OMA" id="CERTERH"/>
    <dbReference type="OrthoDB" id="5308957at2759"/>
    <dbReference type="PhylomeDB" id="B8MN61"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED14510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="277" mass="32688" checksum="35184C95890753C7" modified="2009-03-03" version="1">MEEAAESLNSVFRKVKSVNDGEILASCYYLNQIGEMINDYSHLYDFLRWLYKLAWEELRSSTASIVRLLHALCQMSHDTLMYTLRIGYLRSIHCLQMVVRSTHHLTILSMWVNYVKHWNKHETHHDVLAAKYDQLLRETRNRDPPDLKQEIAVLHGFSYFSYYSLKNDTLSMRLLVEMLDKCGQFLEDKNEYEWSFETQAFAFASKATAMLFEKKASHLAGSYLEKAILILERGDRECRTRAVALIEELILWCERTERHNQVESLREKQNFLLCSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8MN83</accession>
    <name>B8MN83_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_107390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486770.1">
        <property type="nucleotide sequence ID" value="XM_002486725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MN83"/>
    <dbReference type="GeneID" id="8106768"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_107390"/>
    <dbReference type="eggNOG" id="ENOG502SVBM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067893_1_0_1"/>
    <dbReference type="InParanoid" id="B8MN83"/>
    <dbReference type="OMA" id="WHPINNT"/>
    <dbReference type="PhylomeDB" id="B8MN83"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="48"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="223" mass="24518" checksum="DBDF57A0B4ED9C1E" modified="2009-03-03" version="1">MSERRKASGPPSYAPLQLTLKKPRISYSFRFFRPQESCSRAGEAAKALTTLPEVYFPQTTILAGDLNLLHNRWQPSLQHSPTTFAEPFINWLDLQGLVLISDIDCPTHERGNVLDLSFASSPLALAGAKASIASHLDATSNHQPLITTVPWDQRYKKTAQKLRFDTLDHTSFLSLLTSNLTGTESSAATEEDLDTLAEKLTSAIQGAYRGSAKRTMIQGIGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNJ4</accession>
    <name>B8MNJ4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldose 1-epimerase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_103100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486321.1">
        <property type="nucleotide sequence ID" value="XM_002486276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNJ4"/>
    <dbReference type="FunCoup" id="B8MNJ4">
        <property type="interactions" value="769"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MNJ4"/>
    <dbReference type="GeneID" id="8102929"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_103100"/>
    <dbReference type="eggNOG" id="KOG1371">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031753_3_0_1"/>
    <dbReference type="InParanoid" id="B8MNJ4"/>
    <dbReference type="OMA" id="IYHHISR"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="PhylomeDB" id="B8MNJ4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000015">
        <property type="entry name" value="Aldose 1-epimerase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018052">
        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF0">
        <property type="entry name" value="GALACTOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED14083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="331" mass="36628" checksum="39ACDEABDE233024" modified="2009-03-03" version="1">MSNPDESAFTFLPLGAIIQEFNVGGTNIVQGFKTQEDYIKYNTPYFGATIGRVANRLKDGLLQNVNGQTYSLEKTNAPNALHGGSKGWDKRIFEGPKAVNRNGKEGLFFKYLSKDGEEGYPGTVEVRVWYTASKEDGKTVLETEYEAELVGDEVEETAVNITNHSYFNISGGPDISGTKAKLATDWHLPFDSTAIPLGTIDHFSKIKVAEPFILGGPDAEIDDCFLIETDPSKVPLDTRPQALHLLAEFSHDNTNLHLEVYSTEPAFQFYTGNFIDVPAVNGLPARGKYAGFCVEPSRYVNAPNVPEWRHMAVLKKGTIYGSKVVYKAWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNM0</accession>
    <name>B8MNM0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA binding protein Rnp24, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_103330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486347.1">
        <property type="nucleotide sequence ID" value="XM_002486302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNM0"/>
    <dbReference type="FunCoup" id="B8MNM0">
        <property type="interactions" value="863"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MNM0"/>
    <dbReference type="GeneID" id="8103036"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_103330"/>
    <dbReference type="eggNOG" id="KOG4210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027451_1_1_1"/>
    <dbReference type="InParanoid" id="B8MNM0"/>
    <dbReference type="OMA" id="RVWVNQL"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="PhylomeDB" id="B8MNM0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF95">
        <property type="entry name" value="NUCLEOLAR PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="87"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="189"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="255"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="322"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED14109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="385" mass="42978" checksum="14412F99D8C72E92" modified="2009-03-03" version="1">MPGFKEEDHDMNEIKEEKDTSHKKRKLNDVPEIEIDVSAPEPPSKKALRKAKKKDVGPTEKTAVKSETEATEATTKNGKDGKRSEYATKEDIRKFFVEGCTFTEATITRIHLPMGPSRGFTPQNKGFAYVDFANKKAMDEAVGLSEKFIAGRRVLIKGAQNFEGRPAEHQRAGSSKAGAAATSAHLPSRRIFVGNLGFDATKETVQEHFEPCGAITNVHLATFEDSGKCKGYGWVEFETIEAAQHAVNGFVKIAEDDEEEEEEVKDESSSSEDEQSEEKTGKKTKKRISADKKKKPRTKKVWVNRLLGRQLRMEFAEDAATRYKKRFGKDSKKGGSFGDEEQDGGSGHRGRNDRRPKEDSRYSHDTVQRLTGAIVEAKGKKLTFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPC1</accession>
    <name>B8MPC1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase SirN-like, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_105710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486598.1">
        <property type="nucleotide sequence ID" value="XM_002486553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPC1"/>
    <dbReference type="STRING" id="441959.B8MPC1"/>
    <dbReference type="GeneID" id="8100430"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_105710"/>
    <dbReference type="eggNOG" id="ENOG502SPBH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_9_3_1"/>
    <dbReference type="InParanoid" id="B8MPC1"/>
    <dbReference type="OMA" id="PAMTDFA"/>
    <dbReference type="OrthoDB" id="4221597at2759"/>
    <dbReference type="PhylomeDB" id="B8MPC1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF105">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED14360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="305" mass="33840" checksum="AAC354FBAB8BCDC1" modified="2009-03-03" version="1">MATMTETSNIANSQGMDALMEDAQRRGFQEEIDRLTDNHRVYTDAAGGKLSFAPIDWQQPGLRILDSATADGIWLQDLRKEIGPAAEKQTFIGTDLVTDLFPNPPPEGIQFVKQSITEPWPQDWKESFDLVHQRQVLGFCGNFGLDQAVRNLCELAKPGGYVELIELDCDQSVLKEGSVAQEFFRLLEQIWQIKKMGGNFGPNLKDWMVESGLEDVQQTLLHCKVGAQAKPELRKASINGASGAGPMIVALAKTLPELQGFTDEQLDTLNDRIRKELEEVGCEYQSFSVIGRVPAGGLPPYKKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPV1</accession>
    <name>B8MPV1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_052800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486870.1">
        <property type="nucleotide sequence ID" value="XM_002486825.1"/>
    </dbReference>
    <dbReference type="GeneID" id="8098229"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_052800"/>
    <dbReference type="eggNOG" id="ENOG502S0H3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_26_1_1"/>
    <dbReference type="InParanoid" id="B8MPV1"/>
    <dbReference type="OMA" id="ILIRLAX"/>
    <dbReference type="PhylomeDB" id="B8MPV1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="354" mass="39031" checksum="97F735A3E375B35A" modified="2009-03-03" version="1">MLPGTLAAADFTAFQRTIPSSDIVIFSDGSRLIDGRAGGGYIGFQAHHQFLRSSLSYGHGKEVFDTEAEAALAGAQAAITYPTAQFATNLWICLDNLEVATRLLSPSTGSSQEVFESFRTLAAAWPLRERLPHTKSGSIQIRWVPGHAKIPETKRLISLPRGAASPLLLSEILIRLAXXXSSYASLKRHAKTQSLSTAQSQWQKVAPQSYQDLEITTSPKRPGELQLNRLDLGRIIAAHTGHGDFADYHERFNHDDAYLLCRCRTRKAPLHFFFCHIAKRRAPRPPGPPSEEEKSTYLTPRLRLIPQFFDDGDDILDGDEDQGLQDVVEDGAGAAEGAGHGPEREFDRAERGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPW3</accession>
    <name>B8MPW3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_053670</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486964.1">
        <property type="nucleotide sequence ID" value="XM_002486919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPW3"/>
    <dbReference type="FunCoup" id="B8MPW3">
        <property type="interactions" value="1351"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MPW3"/>
    <dbReference type="GeneID" id="8098318"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_053670"/>
    <dbReference type="eggNOG" id="KOG2613">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027444_2_0_1"/>
    <dbReference type="InParanoid" id="B8MPW3"/>
    <dbReference type="OMA" id="VILVRKH"/>
    <dbReference type="OrthoDB" id="203821at2759"/>
    <dbReference type="PhylomeDB" id="B8MPW3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="9">
        <location>
            <begin position="26"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="11">
        <location>
            <begin position="259"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="10">
        <location>
            <begin position="323"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="471"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="488"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED12853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="523" mass="59982" checksum="02F4115D64CE45A5" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQE8</accession>
    <name>B8MQE8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_058380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487461.1">
        <property type="nucleotide sequence ID" value="XM_002487416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQE8"/>
    <dbReference type="GeneID" id="8106440"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_058380"/>
    <dbReference type="HOGENOM" id="CLU_2484849_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQE8"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="PhylomeDB" id="B8MQE8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED13350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="87" mass="10047" checksum="4398AF2ACF695781" modified="2009-03-03" version="1">MTPTTSQVNLGHTIQTTDLIVQLVLKFYPIYRVEKAFMTTSMQDNSFREMDGVPLALTSAGMYLQHTTMSVKDYPQIYQDLWESLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQJ8</accession>
    <name>B8MQJ8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MMS19 nucleotide excision repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_058880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MET18/MMS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487511.1">
        <property type="nucleotide sequence ID" value="XM_002487466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQJ8"/>
    <dbReference type="FunCoup" id="B8MQJ8">
        <property type="interactions" value="983"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MQJ8"/>
    <dbReference type="GeneID" id="8106490"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_058880"/>
    <dbReference type="eggNOG" id="KOG1967">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005943_1_0_1"/>
    <dbReference type="InParanoid" id="B8MQJ8"/>
    <dbReference type="OMA" id="FSFMPEF"/>
    <dbReference type="OrthoDB" id="342900at2759"/>
    <dbReference type="PhylomeDB" id="B8MQJ8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039920">
        <property type="entry name" value="MMS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024687">
        <property type="entry name" value="MMS19_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029240">
        <property type="entry name" value="MMS19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891">
        <property type="entry name" value="DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891:SF0">
        <property type="entry name" value="MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12460">
        <property type="entry name" value="MMS19_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14500">
        <property type="entry name" value="MMS19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MMS19 N-terminal" evidence="7">
        <location>
            <begin position="40"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="MMS19 C-terminal" evidence="6">
        <location>
            <begin position="545"/>
            <end position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED13400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1095" mass="121308" checksum="C8EF6BED14800334" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B8MR50</accession>
    <name>B8MR50_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosome biogenesis ABC transporter Arb1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_054570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EED12945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002487011.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="B8MR50">
        <property type="interactions" value="999"/>
    </dbReference>
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    <dbReference type="GeneID" id="8100395"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_054570"/>
    <dbReference type="eggNOG" id="KOG0927">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_6_1"/>
    <dbReference type="InParanoid" id="B8MR50"/>
    <dbReference type="OMA" id="DWMGQWT"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="PhylomeDB" id="B8MR50"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000549">
        <property type="entry name" value="ABC transporter ATP-binding protein arb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000618">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="97"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="408"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED12945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="629" mass="69944" checksum="F1E2786B6770B4E0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8MS64</accession>
    <name>B8MS64_TALSN</name>
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        <submittedName>
            <fullName evidence="2">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_001900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002487731.1"/>
    </dbReference>
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    <dbReference type="STRING" id="441959.B8MS64"/>
    <dbReference type="GeneID" id="8098684"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_001900"/>
    <dbReference type="eggNOG" id="ENOG502S3ED">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013866_1_1_1"/>
    <dbReference type="InParanoid" id="B8MS64"/>
    <dbReference type="OMA" id="RAFFHDY"/>
    <dbReference type="OrthoDB" id="3525185at2759"/>
    <dbReference type="PhylomeDB" id="B8MS64"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="438" mass="47815" checksum="0B3A1E8B6AC8AA12" modified="2009-03-03" version="1">MARRCSLSPRVPVPGTDTIPDDAPPNEIPDHLIEELALRAFFHDYCVIPVNPALSRGFLARLEPMVHRLGLQSPVANACKAVAFACHGLKLSRPFLTQKAETLYHELLGFLARSIQNCAATAGPEMFVIAILMGLYEMIMAGETDPGHHNAHAGGLAAILQIENSPRGLLHAARSGHPLVVNPMLQNKGIFTGPSPGGDSQDLDAILVKTASLWQKSETFLSNPFCPLFFDQLYGLKQEATALYRDLIGWQTTQVEDIKPTTIGYVRPSPGELSPGVGCWPGRIDTYVDLYVAGVWNVSRVARCFLIHLLQKLSNILDATENDSRYYEDVVEVFNDILASIPYHLTEDSRSFLAHGAASSEITNPGRPVGGLLLLHPIYVVSQLPIVPADMQEYLRRCMAWIGTHMGIGQACLLAKAPHIEGQYFACGCMIVCAGLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSW9</accession>
    <name>B8MSW9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_001550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487738.1">
        <property type="nucleotide sequence ID" value="XM_002487693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSW9"/>
    <dbReference type="STRING" id="441959.B8MSW9"/>
    <dbReference type="GeneID" id="8098649"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_001550"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_22_1"/>
    <dbReference type="InParanoid" id="B8MSW9"/>
    <dbReference type="OMA" id="QKHANDH"/>
    <dbReference type="OrthoDB" id="4227267at2759"/>
    <dbReference type="PhylomeDB" id="B8MSW9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="383" mass="42354" checksum="A2F6AAE560A81221" modified="2009-03-03" version="1">MPPLKALESCNLYTVGWITALPLERVAATAMLDEEHEQPLDLVQPIHDTNAYSWGRIGEHNVVIASLGAGVYGTISAATTALPMLSTFPQIRIGLLVGIGAGVARPDEGLDIRLGDVAVSQPHGNNGGVIQYDLFKAKSGNQRESRSFLNRPPEVLLKALAKLQAEHERRPSKVPEFLAQMAREYPRMANSKNGYVHQGFEDDRLFKATEPYEEILREKRDSTEPQIHYGVIASGNTLFKDSVYRDEILKDVGKECICFEMEAAGLMNNFPCIVIRGICDYADSHKNDRWQRYAAATAAAYAKELLGYVPVQDLQRTQKAIEVAEDKGHQYSIHIGDTKYQGNITNNSGVVMGNAYASAKDGIRITGSNNYYGSDWNPSPTYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTZ8</accession>
    <name>B8MTZ8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">cAMP-dependent protein kinase pathway protein (Som1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_006520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488286.1">
        <property type="nucleotide sequence ID" value="XM_002488241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTZ8"/>
    <dbReference type="STRING" id="441959.B8MTZ8"/>
    <dbReference type="GeneID" id="8105337"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_006520"/>
    <dbReference type="eggNOG" id="ENOG502R28W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8MTZ8"/>
    <dbReference type="OrthoDB" id="5600002at2759"/>
    <dbReference type="PhylomeDB" id="B8MTZ8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12610:SF12">
        <property type="entry name" value="SEQUENCE-SPECIFIC SINGLE-STRANDED DNA-BINDING PROTEIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12610">
        <property type="entry name" value="SINGLE STRANDED DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="426"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="644"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="440"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="476"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="513"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="581"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED12632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="808" mass="89724" checksum="C1916201BF0369BF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUF8</accession>
    <name>B8MUF8_TALSN</name>
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        <submittedName>
            <fullName evidence="11">Benzoate 4-monooxygenase cytochrome P450, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_109770</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EED11797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488553.1">
        <property type="nucleotide sequence ID" value="XM_002488508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUF8"/>
    <dbReference type="STRING" id="441959.B8MUF8"/>
    <dbReference type="GeneID" id="8107209"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109770"/>
    <dbReference type="eggNOG" id="KOG0159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_4_1"/>
    <dbReference type="InParanoid" id="B8MUF8"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="PhylomeDB" id="B8MUF8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED11797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="479" mass="54586" checksum="F14091462561242B" modified="2009-03-03" version="1">MPTTFIEALYMAWVSWPVWTKLEVLLFAITAYIIGIILYRLYLSPLAGFPGPKIAAVTTLYEFYYDAVKGMKLYEHIQALHGIYGPIIRISPHELHIDDPDFYRTLNRKNNLDKCPRYYAIADTLVTTPDHERHYHWRAGVQSYYKSAAERYEPIIYGVVKRFSRGLTDSVNLSSAFRTLTYEIICRVYLVPNPEGLLASDFAAHLNRSFGQFIRIMTLLRLLFGHTIANWIGGAGNVGFKLLALFPKRLHYHVTGWSLENENSIVHLQQKLARLVIDPLISSESLPDDPMCPMLPAIYASDKVPPEAKKRSSLLPDTLGVVLAGTEATANVLDTIMYYLLKDKEKLERLQTELWETLPGNSENVDFQQLKDLPYLHGTKLTASLRLERGSEFRTPRILHEPLCYNGQFVIPAGTSISVTQKTLHDNPKIFEKPSEFQPDRWLDDDKKQAMLGYLVPFGIGQRSCLGMQYVLLNPTSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUN7</accession>
    <name>B8MUN7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine/threonine protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_108860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488461.1">
        <property type="nucleotide sequence ID" value="XM_002488416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUN7"/>
    <dbReference type="STRING" id="441959.B8MUN7"/>
    <dbReference type="GeneID" id="8103142"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_108860"/>
    <dbReference type="eggNOG" id="KOG0578">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076146_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUN7"/>
    <dbReference type="OMA" id="METPWNT"/>
    <dbReference type="OrthoDB" id="4215001at2759"/>
    <dbReference type="PhylomeDB" id="B8MUN7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED11705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="311" mass="35942" checksum="6B8DE6BCD293142B" modified="2009-03-03" version="1">MSLLKVGQTLRGMLGKYVIRKQIQETVWFAENQRKETVVVKGVQGHPRVENERDLLQRFQPSITHLRPLLDEIQDPAAPPIIVLKHLDDHLLNSSIKKILNQKELKFVARYILEALSVLHKEGYVHTDVKLDNIFVNYQNGDNRFSEVQLGDLGGCYSVDSEFARGGTPVGAAMWSSPEVIMETPWNTATDIWSFGTVLISLIYGGDFNLFRPRTVPYGHEEYNLEVLKQQFRYFGPFPAKYEEIASPETVTAILYLMHEIPQSQTTPFSQTTEREVSLKDKEFISKIMKLDWRDRPTAQELLNDRWFLNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUY1</accession>
    <name>B8MUY1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_110020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488578.1">
        <property type="nucleotide sequence ID" value="XM_002488533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUY1"/>
    <dbReference type="STRING" id="441959.B8MUY1"/>
    <dbReference type="GeneID" id="8107234"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_110020"/>
    <dbReference type="eggNOG" id="ENOG502SC56">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_455739_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUY1"/>
    <dbReference type="OrthoDB" id="4368687at2759"/>
    <dbReference type="PhylomeDB" id="B8MUY1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="302"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="599" mass="66250" checksum="133DA045F85DEA9D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MV06</accession>
    <name>B8MV06_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_110750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488652.1">
        <property type="nucleotide sequence ID" value="XM_002488607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MV06"/>
    <dbReference type="STRING" id="441959.B8MV06"/>
    <dbReference type="GeneID" id="8101447"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_110750"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064547_0_0_1"/>
    <dbReference type="InParanoid" id="B8MV06"/>
    <dbReference type="OMA" id="RYERHQA"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="PhylomeDB" id="B8MV06"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="16"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="296" mass="33941" checksum="25BED75A9EDCE3CD" modified="2009-03-03" version="1">MFQGHPYHSLQVPSDEPFKLKPSPGKGWGAFATRRIERGSIIFTEKPLFVIRKPHTEITEGYVWAAFQQLSPSEKEQFLCLRDNGSRSFTYMEEAFAENSFAISRDNSLRSQGTSIHGLFLLHSRFNHSCIPNSKIPNTDQEIITSFATQDIAAGHEITFCYNTDFECRLRHERHQALRFVCDCKACLIDTQFQQLSDMRRTLIRGLQYLTLGVDLNGQKQQMVSPIIFDPYLKKAAETFQIPLSARLIYNLFIIVLLEEEGLPKNNFISEALLQALLGDSERILCEELCSMRFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MV71</accession>
    <name>B8MV71_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_008230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962662">
        <property type="protein sequence ID" value="EED11527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488708.1">
        <property type="nucleotide sequence ID" value="XM_002488663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MV71"/>
    <dbReference type="STRING" id="441959.B8MV71"/>
    <dbReference type="GeneID" id="8110141"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_008230"/>
    <dbReference type="eggNOG" id="KOG0730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004471_6_5_1"/>
    <dbReference type="InParanoid" id="B8MV71"/>
    <dbReference type="OMA" id="TIVETWD"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="PhylomeDB" id="B8MV71"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="718"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED11527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="922" mass="103621" checksum="26314F3DF67C8A7B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MVI3</accession>
    <name>B8MVI3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kinesin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_007940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962663">
        <property type="protein sequence ID" value="EED11504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962663">
        <property type="protein sequence ID" value="EED11505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488820.1">
        <property type="nucleotide sequence ID" value="XM_002488775.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488821.1">
        <property type="nucleotide sequence ID" value="XM_002488776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MVI3"/>
    <dbReference type="STRING" id="441959.B8MVI3"/>
    <dbReference type="GeneID" id="8108948"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_007940"/>
    <dbReference type="eggNOG" id="KOG1840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_994591_0_0_1"/>
    <dbReference type="InParanoid" id="B8MVI3"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="280" mass="31220" checksum="E03374224AC22E3D" modified="2009-03-03" version="1">MSAADDTTCTSSPTDSLVLGAQSHLPTLLNPVKAVDTMTSILWNCVKLNNTISKYGRQTQQIWSTTEVEKMRLYVDDIAQREYEEAKLEVQVMETRKTVLGAEHPSTLTSMANLASTYRNQDRWNEAEKLEVQVMETRKTVLGAEHPDTLSSMNNLSYTWRSQGKIQDALALMKQCSHLRNKVLGSSHPHSVSSSRSLNDWMDEYNSLRDQTPLTENSCLQPLREVLADSTAAVQNSQATRGINLTYAPAVKLFLGNHPLIIAARTPSPRAEGQDIQDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8LSV8</accession>
    <name>B8LSV8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">DUF221 domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_064230</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340341.1">
        <property type="nucleotide sequence ID" value="XM_002340300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LSV8"/>
    <dbReference type="FunCoup" id="B8LSV8">
        <property type="interactions" value="177"/>
    </dbReference>
    <dbReference type="GeneID" id="8105984"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_064230"/>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002458_2_1_1"/>
    <dbReference type="InParanoid" id="B8LSV8"/>
    <dbReference type="OMA" id="DPTQVIW"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="PhylomeDB" id="B8LSV8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF26">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G10920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="500"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="548"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="598"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="626"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="665"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="691"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="12">
        <location>
            <begin position="31"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="13">
        <location>
            <begin position="202"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="10">
        <location>
            <begin position="407"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="11">
        <location>
            <begin position="796"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="743"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="241"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="757"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED22954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="895" mass="100615" checksum="963BFCA97F190A72" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTN4</accession>
    <name>B8LTN4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_070390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341013.1">
        <property type="nucleotide sequence ID" value="XM_002340972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTN4"/>
    <dbReference type="GeneID" id="8104217"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_070390"/>
    <dbReference type="eggNOG" id="ENOG502SFRW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1854841_0_0_1"/>
    <dbReference type="InParanoid" id="B8LTN4"/>
    <dbReference type="OrthoDB" id="4226915at2759"/>
    <dbReference type="PhylomeDB" id="B8LTN4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="14692" checksum="E3D05BE799E3648D" modified="2009-03-03" version="1">MPRGWNLDPVAGKAPKRLASRYYQLKTGHAPIGTYLHRIGRRESPECQACKEPHETVRHVLFGCRGRRTGRRALYRALEKAGVPLPTAAEESPEARLFAEPIVTQAREAESSDAWGWDTLEEGGPGVTLEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVX0</accession>
    <name>B8LVX0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ethanolamine kinase</fullName>
            <ecNumber evidence="3">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_077030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="3"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341723.1">
        <property type="nucleotide sequence ID" value="XM_002341682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVX0"/>
    <dbReference type="STRING" id="441959.B8LVX0"/>
    <dbReference type="GeneID" id="8104687"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_077030"/>
    <dbReference type="eggNOG" id="KOG4720">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012712_1_1_1"/>
    <dbReference type="InParanoid" id="B8LVX0"/>
    <dbReference type="OMA" id="FALIPKY"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="PhylomeDB" id="B8LVX0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="154"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED24336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="422" mass="47550" checksum="1B2A3D10E25385D5" modified="2009-03-03" version="1">MANESLRYIPLTYDHADSQASALRLVLTIKPEWEGPGNNIEFVRFTDGITNTLLKIVNRKPGWTDEQIDNEAVLMRAYGNHTEILIDRERETRSHSLLAQHGLAPPLLARFKNGLLYCFIRGHVTSPSDLINPSVWRGVARRLGQWHAVLPIAGSADDSQTPSSTHDEDNLYKSDGTPKAPTAGTITPIRPRQAGPNLWTVLQKWILALPVQTEEQRARQKALQVELERTLHEFDDGSGIGANGLVFAHCDLLSANVIVIPHAQANGVTNGHSDSQDVHFIDYEYATPSPAAFDIANHFAEWGGYDCDYNMLPTRSVRREFLTEYVKSFAQHGGKGVDPDQQQKVVEKLFQDVDRFRGIPGFYWGVWALIQATISQIDFDYASYAEVRLGEYWAWRREQDGSKSAEADEESPLRERRWAQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWG6</accession>
    <name>B8LWG6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Complex I-ESSS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase ESSS subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSTA_076450</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Complex I is composed of 45 different subunits. Interacts with BCAP31.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB11 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341664.1">
        <property type="nucleotide sequence ID" value="XM_002341623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWG6"/>
    <dbReference type="STRING" id="441959.B8LWG6"/>
    <dbReference type="GeneID" id="8101021"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_076450"/>
    <dbReference type="eggNOG" id="ENOG502S7S9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138649_2_1_1"/>
    <dbReference type="InParanoid" id="B8LWG6"/>
    <dbReference type="OMA" id="EDWEDIW"/>
    <dbReference type="OrthoDB" id="2147978at2759"/>
    <dbReference type="PhylomeDB" id="B8LWG6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019329">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ESSS_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637:SF1">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10183">
        <property type="entry name" value="ESSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EED24277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="113" mass="12710" checksum="E53DA866900542B1" modified="2009-03-03" version="1">MRQATSIALRSRCLLRAPQTSRAFSTQSTLRSADHGNHYDPPSGWLFGVKPGQKYVKEGWENIWYIGFIGSLVAAGVAYVFKPDTSIQTWALEEARRRLEAEGILEDPEKAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWM4</accession>
    <name>B8LWM4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aromatic ring-opening dioxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_077800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341808.1">
        <property type="nucleotide sequence ID" value="XM_002341767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWM4"/>
    <dbReference type="STRING" id="441959.B8LWM4"/>
    <dbReference type="GeneID" id="8110254"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_077800"/>
    <dbReference type="eggNOG" id="ENOG502S0K5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046582_4_0_1"/>
    <dbReference type="InParanoid" id="B8LWM4"/>
    <dbReference type="OMA" id="FDPHFHM"/>
    <dbReference type="OrthoDB" id="7396853at2759"/>
    <dbReference type="PhylomeDB" id="B8LWM4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF1">
        <property type="entry name" value="AROMATIC RING-OPENING DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G00640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="8"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED24421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="291" mass="32688" checksum="C1ECB74FDDF15EE2" modified="2009-03-03" version="1">MSTEPTPVHFFSHGSTMMLGEESTSADYWKKCGDEALANGIKGVVMMGAHWDCSGLNKIQVAMNPKPNKSPVAYVHPSKYVDYELNPDLELGQACIELLRKDGFDASADEKFDWIHDTYLILIRMFPKKCPPTTIISANSRFDPHFHMRVGAALRPLREQGYLIIGTGGAVHNLYRNIWAPMLNYMDNFAQLTPPEDWAMDFRQAVEDAIVNNSGPALRRAITRLMKHPKFREAHATDDHFMAALFVAGAVGSEQDRGVYGRLGAESWELTNMCNSQFTFGEWPKISQTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWU6</accession>
    <name>B8LWU6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_079340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341966.1">
        <property type="nucleotide sequence ID" value="XM_002341925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWU6"/>
    <dbReference type="STRING" id="441959.B8LWU6"/>
    <dbReference type="GeneID" id="8107620"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_079340"/>
    <dbReference type="eggNOG" id="ENOG502T4BB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007466_0_0_1"/>
    <dbReference type="InParanoid" id="B8LWU6"/>
    <dbReference type="OMA" id="FASMVLM"/>
    <dbReference type="OrthoDB" id="5040840at2759"/>
    <dbReference type="PhylomeDB" id="B8LWU6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098">
        <property type="entry name" value="RAPSYN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098:SF108">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="896"/>
            <end position="1211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED24579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1221" mass="137435" checksum="3248FD445C136665" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8LX09</accession>
    <name>B8LX09_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vegetative specific protein H5, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_079970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002342029.1">
        <property type="nucleotide sequence ID" value="XM_002341988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LX09"/>
    <dbReference type="STRING" id="441959.B8LX09"/>
    <dbReference type="GeneID" id="8106605"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_079970"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_811763_0_0_1"/>
    <dbReference type="InParanoid" id="B8LX09"/>
    <dbReference type="OMA" id="DWLERFF"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="PhylomeDB" id="B8LX09"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="110"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED24642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="342" mass="38490" checksum="30FC472697E5F0DA" modified="2009-03-03" version="1">MCPAAHYHRGFIQITPKFLDLQAKTCDDELKDFVKEKAPFKLNDYKSHRVAIEDSPETVVENYKKYMEGPEMPSEGDKMTHEFLQFGNIKLSIFTPKNQRPPAGGRPCLYFIHGGGFVVNNQCSGITSIFPCIDRLNAVCVSIDYSVAPECKAPSQVEQCYDGLLAFWNRKKYSGEINFDEVAVIGRSAGAALLVGLNLKILEGKEMKIRCNIMTFPMVDDACNTGSHSKFRNAPFLPHETVKDCWGHYLNHRGGDKYVVPGKATIKDLEEFPPTLVEVAKADVLHDEGVNFYEKLNSAGVGITIKSFNGYHCFDSTDTEISKRAKRERVEFLEEQGMRPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8LX47</accession>
    <name>B8LX47_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_061850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340084.1">
        <property type="nucleotide sequence ID" value="XM_002340043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LX47"/>
    <dbReference type="GeneID" id="8102327"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_061850"/>
    <dbReference type="HOGENOM" id="CLU_077443_0_0_1"/>
    <dbReference type="InParanoid" id="B8LX47"/>
    <dbReference type="OrthoDB" id="4507940at2759"/>
    <dbReference type="PhylomeDB" id="B8LX47"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="29473" checksum="712B020D7ECAC05C" modified="2009-03-03" version="1">MLAALSSAKEKLSEYYAMTDHVSGDLYAIGTILAPQNKLEFFSTSEWEPEWRVRYRKSLEDHEQPPMTRYHVILGADILTTPASGSGVERLFNSARNICHYRRGSLKPHTIKELMLFMCTTKFNLESEELSLMDEYLTTQEIQRAREERDAQRALEAQNTKYDFDPISDSEEAESEDESLVLPQSPQASQARSQHSLGKRPAREEEPLIELDGNEEDEVPLPYNRHLVTVSSTQRRSSGRQPKRSKRDEDFVYKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXA1</accession>
    <name>B8LXA1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CorA family metal ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_066320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340569.1">
        <property type="nucleotide sequence ID" value="XM_002340528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXA1"/>
    <dbReference type="STRING" id="441959.B8LXA1"/>
    <dbReference type="GeneID" id="8105644"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_066320"/>
    <dbReference type="eggNOG" id="ENOG502SJAE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034568_1_0_1"/>
    <dbReference type="InParanoid" id="B8LXA1"/>
    <dbReference type="OMA" id="RRFVEHW"/>
    <dbReference type="OrthoDB" id="3231000at2759"/>
    <dbReference type="PhylomeDB" id="B8LXA1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED23182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="57522" checksum="1C8055A49A43293B" modified="2009-03-03" version="1">MDTSYSDYVTALARQNPSLKRLSDFLRHQLRTSCNSLVTYVEIGTTGDVGIAQETSTTKLIDLVNSGLNKSIIVTVENIHPDDVESLGSCLDIDPFFFCGHIAPSYADIERNPLPSLLALPPSRLVSGSFINIHYQKLLDLGDEVALSRVPYDLALMANVTRSVRRLPALSGRSIGILRACTSLIKKDLPGGVWISLILIDPTSEILVHPIRGIHDIFFGPIIPQSPRRIATETFCKPSYAEHQSASSGNRNIEPLKPSEEPLSFFHASNLRWRGGNPSILALAYNPIQAVVQEWILYALLMGRYVKYYEYSSETVQMRRESFEEYDIIELHRWRRRSLQSLHKLGIVRRFVEHWASKEKNLSLDMGVTNKATTQEESVIWNLLIGDIKYVEEQIMQHARSLEALNPIITALIQLADTKRAISQAEDTRRLTYIAIIFLPMSFLTGLFSMSEPYGPGSDRFWIYWVVALPLTAFIIVVLVLDLRFRFLSIFWAIMQKRNSLPRGKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXX9</accession>
    <name>B8LXX9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_062810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340181.1">
        <property type="nucleotide sequence ID" value="XM_002340140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXX9"/>
    <dbReference type="GeneID" id="8106649"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_062810"/>
    <dbReference type="eggNOG" id="KOG1546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029389_3_0_1"/>
    <dbReference type="InParanoid" id="B8LXX9"/>
    <dbReference type="OMA" id="KMVTMFS"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="PhylomeDB" id="B8LXX9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="6">
        <location>
            <begin position="3"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED22794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="318" mass="35564" checksum="8A431F0C0E0CD1FF" modified="2009-03-03" version="1">MPRRKALIIGINYYGSEHALKGCINDAYNIRQFLVEERGFSPDQRDMVMLTDEPKNEGTPFYPTGQNLIAAFKWLVSYNNPGDSVWLSYSGHGGQVADDYGDRESGFNDTICPVDFETNGQITSSTLHKLIISPMNPYARLTILFDCCHSGSAVELPYTYRPDADGNINLVNNLKEGVHLAMEASNLLQGGFSMDRLDDARSFVAEAATFFHSLHHQPEEADEQGLVDEGFHENWRNEAKDAWMFSGCADGQTSADTSIRGRATGAMSWAFMNVMRENPQQSYLDVLANTRYLIQQHYSQIPQLSVGGEYDLSQPVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8LY82</accession>
    <name>B8LY82_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbon catabolite repressor D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_067620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. May be involved in signaling by recognizing appropriately phosphorylated substrates via its arrestin domains and then recruit a HECT-type ubiquitin ligase such as hulA, leading to ubiquitination of the substrate, providing a link between ubiquitination and phosphorylation in protein regulation and stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with hulA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340714.1">
        <property type="nucleotide sequence ID" value="XM_002340673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LY82"/>
    <dbReference type="FunCoup" id="B8LY82">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LY82"/>
    <dbReference type="GeneID" id="8101037"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_067620"/>
    <dbReference type="eggNOG" id="KOG3780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018982_2_0_1"/>
    <dbReference type="InParanoid" id="B8LY82"/>
    <dbReference type="OMA" id="GMATPFH"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="PhylomeDB" id="B8LY82"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000018">
        <property type="entry name" value="HECT-type ubiquitin ligase-interacting protein creD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="7">
        <location>
            <begin position="182"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="433"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="539"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="458"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="474"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00079835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED23327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="604" mass="67490" checksum="7B220BD1D964451A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYT1</accession>
    <name>B8LYT1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TAM domain methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_068620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340826.1">
        <property type="nucleotide sequence ID" value="XM_002340785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYT1"/>
    <dbReference type="STRING" id="441959.B8LYT1"/>
    <dbReference type="GeneID" id="8102666"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_068620"/>
    <dbReference type="eggNOG" id="ENOG502QR9E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_0_2_1"/>
    <dbReference type="InParanoid" id="B8LYT1"/>
    <dbReference type="OMA" id="HEGSYIY"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="PhylomeDB" id="B8LYT1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED23439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="269" mass="30982" checksum="B383A18455825A2B" modified="2009-03-03" version="1">MQHHIWKQVNDDKLHFAPLRDPKRILDIGTGSGIWPIEMASLFPEASITGTDLSPVQPTEVPPNVHFLVEDATEEWLWEPNHFDYIRLSNMTGSFPSVKDILRKAMRVLKPGGWLEWHDMDPVPRCDDNTVPPPNTEGGFSQYALHDWIELEVKAAEEFEPYRQFLIADKLAAQMREEGYTDVNDRVTKVPLNPWPKDPKLKTLGAWQEENWLTGLSAYTYKPFLALGWTKPEIEVFLVSVRKCISNRHFHAYQNFHAITARKPLPGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZ16</accession>
    <name>B8LZ16_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_082930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478023.1">
        <property type="nucleotide sequence ID" value="XM_002477978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZ16"/>
    <dbReference type="STRING" id="441959.B8LZ16"/>
    <dbReference type="GeneID" id="8105171"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_082930"/>
    <dbReference type="HOGENOM" id="CLU_013929_2_3_1"/>
    <dbReference type="InParanoid" id="B8LZ16"/>
    <dbReference type="OrthoDB" id="4230268at2759"/>
    <dbReference type="PhylomeDB" id="B8LZ16"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="4"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="132"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED21060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="35648" checksum="E37C549BD53A07BB" modified="2009-03-03" version="1">MTHHMGTPPMNQQIEESANYLLAKDFTGPGEPPRAGKTWVYDFVGRLPEKYVRIVQKSQEKERTASEHYGEVEQWFIDLKFMIKHLKIQPRNLWNFDETGFIVGQGKDEAVVTAFPKTSKRVSSLSSRESITVIEGVSAEGKIIPPLLIPKGKVHLEEWYRHLQDDEWLVAPAKNGFITDEIAFEWLQHFQYYSKPEWGLLEWRLLLMDNHTTHLNMQFVEYCHIWHIQPFRFPPHSTHFLQPLDGVPFQQYKHVHGKVVNKVARLDGFDFDKNDFFEELRDIRIKTFTTRTIRNSWRERGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZA9</accession>
    <name>B8LZA9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_088980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478625.1">
        <property type="nucleotide sequence ID" value="XM_002478580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZA9"/>
    <dbReference type="STRING" id="441959.B8LZA9"/>
    <dbReference type="GeneID" id="8104865"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_088980"/>
    <dbReference type="eggNOG" id="ENOG502SGGC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1918482_0_0_1"/>
    <dbReference type="InParanoid" id="B8LZA9"/>
    <dbReference type="OMA" id="FHMVEQC"/>
    <dbReference type="OrthoDB" id="4525115at2759"/>
    <dbReference type="PhylomeDB" id="B8LZA9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="14394" checksum="A23AEBC670E507DA" modified="2009-03-03" version="1">MVNWTDSVNGKFLIMTLQEVTPQVSGEIWEKVAKKMGPGFSANACRQNYAKLLKAQSSDGTVTPSANSSTPKSASRKRKEAPETPSKTPSSRKQKKMTPAAHLGIPEEEAELKPPQTPHLGVKKQLFSEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZH7</accession>
    <name>B8LZH7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyroglutamyl peptidase type I, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_093050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C15 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479022.1">
        <property type="nucleotide sequence ID" value="XM_002478977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZH7"/>
    <dbReference type="STRING" id="441959.B8LZH7"/>
    <dbReference type="GeneID" id="8102549"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_093050"/>
    <dbReference type="eggNOG" id="KOG4755">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043960_0_0_1"/>
    <dbReference type="InParanoid" id="B8LZH7"/>
    <dbReference type="OMA" id="TWRSFAP"/>
    <dbReference type="OrthoDB" id="407146at2759"/>
    <dbReference type="PhylomeDB" id="B8LZH7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="entry name" value="Peptidase C15, pyroglutamyl peptidase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PROTEASE FAMILY C15 PYROGLUTAMYL-PEPTIDASE I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402:SF1">
        <property type="entry name" value="PYROGLUTAMYL-PEPTIDASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED22059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="278" mass="30321" checksum="40C4E3CA61771509" modified="2009-03-03" version="1">MGDVGIVVDPAISPASPPISQSINVLVTGFGPFRSFDVNASFLIAQSLPSAFTLPPKEPVSVPGTAIPAPREVRIYVHPEPIKVSYATIRSQMPDILDGFSRTHNGLRPDLIVHIGIASTRRYYSVESQAHRDNYRIPDVDGRSGYHDGEKIWREKGLSPILVPGPAELSGGGNRHNTSTVQTSGLKITPYPTNDHFLQVWKSFSPANTDLRVSNDAGHYACDFIFYTSLALALEEGRDRSIVFYHVPVATDLESLDLGTKVAVALIKSVVKCWVDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZI1</accession>
    <name>B8LZI1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3597 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_093090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479026.1">
        <property type="nucleotide sequence ID" value="XM_002478981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZI1"/>
    <dbReference type="GeneID" id="8102553"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_093090"/>
    <dbReference type="HOGENOM" id="CLU_1278383_0_0_1"/>
    <dbReference type="InParanoid" id="B8LZI1"/>
    <dbReference type="OrthoDB" id="4500628at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022016">
        <property type="entry name" value="DUF3597"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12200">
        <property type="entry name" value="DUF3597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158634">
        <property type="entry name" value="RPA2825-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3597" evidence="2">
        <location>
            <begin position="6"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED22063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="216" mass="24315" checksum="A2AFA0A35893A87C" modified="2009-03-03" version="1">MDFVLLDLFKFLNLDAGIEFRIKLAKTLNVDVGPNRSAVQNKALHQKLMDELARNNGQLPAKLYRIDEHEKLPPDLLQDVDGTQLKQSQTKNTLDTFSGGYMSEYKDGMLLEKTMEIPLLASTDRKLTKNNSTPSESDESKVLSHSSESTRDLSKSLSGIEAVDSQLAWIFLFQCSLTKVNVEKLARNVKRLIVRFGRNLEGETSEGLHKQAAKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZL5</accession>
    <name>B8LZL5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RING finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_096870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479401.1">
        <property type="nucleotide sequence ID" value="XM_002479356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZL5"/>
    <dbReference type="STRING" id="441959.B8LZL5"/>
    <dbReference type="GeneID" id="8103530"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_096870"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013137_18_3_1"/>
    <dbReference type="InParanoid" id="B8LZL5"/>
    <dbReference type="OMA" id="RTLEEWW"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="PhylomeDB" id="B8LZL5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF69">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="114"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED22438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="178" mass="20831" checksum="4D5C4044F6F283C0" modified="2009-03-03" version="1">MATGYAQMIQAWTQGRPASKHERDTQTQGNSNESVKILLGVVLGVAVFFILSMMIALYCHRRNRRMVEDPNCKISLNRLQKLESVAPTRSLEEWWPTVKESLGLSQGLENHFVCVVCFDEVERTQEIHELKCLHVFHKECLEKWYLRSHYTCPMCHRVFFEERDRFISSANMNFAIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0I3</accession>
    <name>B8M0I3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_085110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478243.1">
        <property type="nucleotide sequence ID" value="XM_002478198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0I3"/>
    <dbReference type="FunCoup" id="B8M0I3">
        <property type="interactions" value="262"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M0I3"/>
    <dbReference type="GeneID" id="8106117"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_085110"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="InParanoid" id="B8M0I3"/>
    <dbReference type="OMA" id="GTNYMGP"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="PhylomeDB" id="B8M0I3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED21280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="322" mass="35699" checksum="F65A9A07C46F9E48" modified="2009-03-03" version="1">MSFIFHRKITYNPDKDIPDLESKVILVTGGNNGLGKETVKELAKHNPTKIYMGARSKAKASAAIAELKEQVPSANIIYLEINLASFSSIKRAAATFLAENDRLHILVNNAGVFATPPGLTEDGYEVQFGTNYMGPALFTKLLLPILEKTASISEGNVRIINISSEIYKLAPKGGLLLAQDKTPLTEISTVARYGQCKLANIYFTKSYAKRYPAIKSVALHPGLVQTNIGGEMKGFSIMSLIFGLLNRVSSVDVATGALNQLWASTFDAEKVNSGAYYIPFFKESNRRDITKDEKKMEELWEWTEKEFKEHGLSSKENLFFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0T6</accession>
    <name>B8M0T6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_087020</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478432.1">
        <property type="nucleotide sequence ID" value="XM_002478387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0T6"/>
    <dbReference type="FunCoup" id="B8M0T6">
        <property type="interactions" value="930"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M0T6"/>
    <dbReference type="GeneID" id="8110108"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_087020"/>
    <dbReference type="eggNOG" id="KOG2515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018152_0_0_1"/>
    <dbReference type="InParanoid" id="B8M0T6"/>
    <dbReference type="OMA" id="PRDMHAK"/>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="PhylomeDB" id="B8M0T6"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF2">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE ALG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED21469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="593" mass="66864" checksum="C590055378E8B83D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1N6</accession>
    <name>B8M1N6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pentatricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_093690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479086.1">
        <property type="nucleotide sequence ID" value="XM_002479041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1N6"/>
    <dbReference type="STRING" id="441959.B8M1N6"/>
    <dbReference type="GeneID" id="8102613"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_093690"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002863_0_0_1"/>
    <dbReference type="InParanoid" id="B8M1N6"/>
    <dbReference type="OMA" id="PQACLYQ"/>
    <dbReference type="OrthoDB" id="411857at2759"/>
    <dbReference type="PhylomeDB" id="B8M1N6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000266">
        <property type="entry name" value="Pentatricopeptide repeat domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057585">
        <property type="entry name" value="TPR_dom_fungi"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24603">
        <property type="entry name" value="TPR_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="356"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat" evidence="7">
        <location>
            <begin position="482"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="969"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="1004"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="781"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED22123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1273" mass="139684" checksum="61126863970FEB86" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1Z7</accession>
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        <submittedName>
            <fullName evidence="9">Importin beta-2 subunit, putative</fullName>
        </submittedName>
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    <gene>
        <name evidence="9" type="ORF">TSTA_086060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478338.1">
        <property type="nucleotide sequence ID" value="XM_002478293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1Z7"/>
    <dbReference type="FunCoup" id="B8M1Z7">
        <property type="interactions" value="1206"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M1Z7"/>
    <dbReference type="GeneID" id="8104571"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_086060"/>
    <dbReference type="eggNOG" id="KOG2023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008136_1_0_1"/>
    <dbReference type="InParanoid" id="B8M1Z7"/>
    <dbReference type="OMA" id="AQEGAMS"/>
    <dbReference type="OrthoDB" id="951172at2759"/>
    <dbReference type="PhylomeDB" id="B8M1Z7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000313">
        <property type="entry name" value="Importin beta-2 subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000219">
        <property type="entry name" value="Importin subunit beta-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin subunit beta-1/Transportin-1-like TPR repeats" evidence="8">
        <location>
            <begin position="510"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
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            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED21375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="928" mass="104256" checksum="B7FDBCCFEC611EF7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8M220</accession>
    <name>B8M220_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_087170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478447.1">
        <property type="nucleotide sequence ID" value="XM_002478402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M220"/>
    <dbReference type="GeneID" id="8100849"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_087170"/>
    <dbReference type="eggNOG" id="ENOG502RNUY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1125164_0_0_1"/>
    <dbReference type="InParanoid" id="B8M220"/>
    <dbReference type="OMA" id="HEVAGCI"/>
    <dbReference type="OrthoDB" id="4503765at2759"/>
    <dbReference type="PhylomeDB" id="B8M220"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002874706" evidence="2">
        <location>
            <begin position="23"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED21484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="247" mass="26431" checksum="FB85B771B5394C7D" modified="2009-03-03" version="1">MRYLTILSALYFTLLYSLPTRALTGGKAWVNFYKDCPNEILEIEEVTIIVSSPKQSAGNRAQSPSSPSASHSIGASSSSSVSIIPSSSAIPSASASSIKLLSASTSSSSVLSPKSKFRSALAARNTEKSTIRSPFVNITQGQCEPVPIVTERHIDSSSVSVGTELLTVTPFQECNITVHEVPGCIDDPLLVAPVKNRKAESTCTPRNFGAFNDVWVRLDCSEIGTALNKFDTAQDSASKTRPLQRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8M274</accession>
    <name>B8M274_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Synaptobrevin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_087740</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the USE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478501.1">
        <property type="nucleotide sequence ID" value="XM_002478456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M274"/>
    <dbReference type="STRING" id="441959.B8M274"/>
    <dbReference type="GeneID" id="8100903"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_087740"/>
    <dbReference type="eggNOG" id="ENOG502SCD1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027976_0_0_1"/>
    <dbReference type="InParanoid" id="B8M274"/>
    <dbReference type="OMA" id="YAWIFGL"/>
    <dbReference type="OrthoDB" id="3231855at2759"/>
    <dbReference type="PhylomeDB" id="B8M274"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15860">
        <property type="entry name" value="SNARE_USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019150">
        <property type="entry name" value="Vesicle_transport_protein_Use1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050">
        <property type="entry name" value="USE1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050:SF7">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="178"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED21538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="36226" checksum="59AC162909417194" modified="2009-03-03" version="1">MTRTILQSHPIHSDSSPETDTYTIDIINLNNLLTRLEQNIFLSSSAEHRLLQQSHFQCARIGANIDYAQTLIKKIERSLPSVKAPAIRHERTTDLAKKRGRYEKIKERFDWIKEDVERRVDREEGDVYQEEDNDDDIWEGLRPVEKGAATGTETELEPEVSNNIISSEETTILRQRRHDKTLSPTTTPSTTAAIASGTSTSPLPKLTPTTTDHNKETTLSTHRAEQESLTTSLLTLASQLKASSESFQTSLENEKGILNRAVEGLDRNMTGMEAAGKRMGVLRRMSEGRGWWGRIMMYAWIFGLWIVALGIVYLGPKLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2P5</accession>
    <name>B8M2P5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transposon, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_091980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478919.1">
        <property type="nucleotide sequence ID" value="XM_002478874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2P5"/>
    <dbReference type="GeneID" id="8098583"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_091980"/>
    <dbReference type="eggNOG" id="ENOG502S2ZX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_4_3_1"/>
    <dbReference type="InParanoid" id="B8M2P5"/>
    <dbReference type="OMA" id="WSDSGCI"/>
    <dbReference type="OrthoDB" id="2917041at2759"/>
    <dbReference type="PhylomeDB" id="B8M2P5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="60"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED21956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="540" mass="61650" checksum="508E572597AD64F3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2W0</accession>
    <name>B8M2W0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="16">1.3.8.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">2-methyl branched chain acyl-CoA dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">2-methylbutyryl-coenzyme A dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">TSTA_094610</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="32" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(2R)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65296"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156439"/>
            <dbReference type="ChEBI" id="CHEBI:156440"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:65297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(2S)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48256"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:88166"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:48257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57336"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:43781"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>2-methylpropanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:44180"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62500"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:44181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:24004"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:24005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:43465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>valproyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65344"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156457"/>
            <dbReference type="ChEBI" id="CHEBI:156458"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:65345"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 27">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Amino-acid degradation; L-isoleucine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 27">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.5" evidence="16"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479178.1">
        <property type="nucleotide sequence ID" value="XM_002479133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2W0"/>
    <dbReference type="STRING" id="441959.B8M2W0"/>
    <dbReference type="GeneID" id="8103791"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_094610"/>
    <dbReference type="eggNOG" id="KOG0139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_0_1"/>
    <dbReference type="InParanoid" id="B8M2W0"/>
    <dbReference type="OMA" id="DAMFSYC"/>
    <dbReference type="OrthoDB" id="10262177at2759"/>
    <dbReference type="PhylomeDB" id="B8M2W0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003853">
        <property type="term" value="F:short-chain 2-methyl fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046395">
        <property type="term" value="P:carboxylic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01158">
        <property type="entry name" value="SCAD_SBCAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000012">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF1">
        <property type="entry name" value="SHORT_BRANCHED CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8 27" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7 27" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 27 31" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="30">
        <location>
            <begin position="61"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="29">
        <location>
            <begin position="176"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="28">
        <location>
            <begin position="283"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00051903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="EED22215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="438" mass="47356" checksum="37148058806B136D" modified="2009-03-03" version="1">MASLSRTLRPLSRTLASGLTTSTRTIPTRSLQYTTRAFSTTPGRRNVDLTELTPTPITHLSETETLMAETVSKFAQEQIGPKVRDMDEAEAMDPAVVEQLFEQGLMGIEIPEEYGGSGMNFTSAIIAIEELARVDPSVSVLVDVHNTLVNTAVMTYGSAETQRRWLPQLASGTVGSFCLSEPASGSDAFALQTKAEKTADGYKINGSKMWITNSMEAGFFIVFANLDPSKGYKGITAFIVEKDTPGFSIAKKEKKLGIRASSTCVLNFDDVEIPKANLLGEEGKGYKIAIGILNEGRIGIAAQMTGLAIGAWENAAGYVWNDRKQFGQLIGNFQGMQHQIAQAYTEIAAARALVYNAARKKEAGQNFVMDAAMAKLYASQVAGRVAGSAVEWMGGMGFVREGIAEKMFRDSKIGAIYEGTSNIQLTTIAKQLQAQYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3A0</accession>
    <name>B8M3A0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_095180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479235.1">
        <property type="nucleotide sequence ID" value="XM_002479190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3A0"/>
    <dbReference type="STRING" id="441959.B8M3A0"/>
    <dbReference type="GeneID" id="8103848"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_095180"/>
    <dbReference type="eggNOG" id="ENOG502RQ03">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1103387_0_0_1"/>
    <dbReference type="InParanoid" id="B8M3A0"/>
    <dbReference type="OrthoDB" id="4402908at2759"/>
    <dbReference type="PhylomeDB" id="B8M3A0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED22272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="252" mass="28661" checksum="F5DDE3C1DB3507AA" modified="2009-03-03" version="1">MELRHGFRLLKASVSEIFDQAQLRIAGHNYMEVEDFDQIDHPAGFEKAPRFITRNFRSALIGSFLIAALLSGIFIPIYTIIRVKERGTAIERGGPFPPRQFEQITFHGLNGNNNVWNNVLPVGAGWVVIDDPEGYNLPPGLPLNGHYNKYGLSWAHQYHCLRRLRLEFWVLIENRSTLVSVQLDETDVIPEVHELKHLEHCHEYLFQAILCNMDMTIEYSTGDGISHGTIDGLGISHTCTKRFSAQMLSSNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3H9</accession>
    <name>B8M3H9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial cation transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_096000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sideroflexin family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479314.1">
        <property type="nucleotide sequence ID" value="XM_002479269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3H9"/>
    <dbReference type="FunCoup" id="B8M3H9">
        <property type="interactions" value="288"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M3H9"/>
    <dbReference type="GeneID" id="8105911"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_096000"/>
    <dbReference type="eggNOG" id="KOG3767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_460176_0_0_1"/>
    <dbReference type="InParanoid" id="B8M3H9"/>
    <dbReference type="OrthoDB" id="6608471at2759"/>
    <dbReference type="PhylomeDB" id="B8M3H9"/>
    <dbReference type="UniPathway" id="UPA00626">
        <property type="reaction ID" value="UER00678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047605">
        <property type="term" value="F:acetolactate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045151">
        <property type="term" value="P:acetoin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17299">
        <property type="entry name" value="acetolactate_decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.80">
        <property type="entry name" value="Hypothetical protein, similar to alpha- acetolactate decarboxylase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005128">
        <property type="entry name" value="Acetolactate_a_deCO2ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00798">
        <property type="entry name" value="mtc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF6">
        <property type="entry name" value="SIDEROFLEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03306">
        <property type="entry name" value="AAL_decarboxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117856">
        <property type="entry name" value="AF0104/ALDC/Ptd012-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="538"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED22351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="593" mass="64728" checksum="DF34383B04C82381" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3M3</accession>
    <name>B8M3M3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DRAP deaminase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_096440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479358.1">
        <property type="nucleotide sequence ID" value="XM_002479313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3M3"/>
    <dbReference type="STRING" id="441959.B8M3M3"/>
    <dbReference type="GeneID" id="8103487"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_096440"/>
    <dbReference type="eggNOG" id="KOG1018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036590_8_0_1"/>
    <dbReference type="InParanoid" id="B8M3M3"/>
    <dbReference type="OMA" id="QCALAKY"/>
    <dbReference type="OrthoDB" id="252265at2759"/>
    <dbReference type="PhylomeDB" id="B8M3M3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18785">
        <property type="entry name" value="Inv-AAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED22395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="253" mass="27975" checksum="A3D67E94AFB226E6" modified="2009-03-03" version="1">MTSSESSHLKYLRECLKLASKSPPRPTNFRVGAILILRPDTPDDTSSDDKILSTGYTMELPGNTHAEQCCLSNYAATHGVYEEQVADAFPSQGERKGRKILLYVTMEPCGIRLSGNTPCVHRIIQTRKRNDDSNNNNGIDKVYFGVKEPGTFVGESQGCKMLTEAGIEWEFVGGLENEILAVATAGHDKGNQKQEAEERGSNIEAISQEERERQAQLPKNPKKRMMDAGVSRGAARVSQLINSTLRRDCSSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4E2</accession>
    <name>B8M4E2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_024610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479571.1">
        <property type="nucleotide sequence ID" value="XM_002479526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4E2"/>
    <dbReference type="STRING" id="441959.B8M4E2"/>
    <dbReference type="GeneID" id="8106678"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_024610"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8M4E2"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="PhylomeDB" id="B8M4E2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF57">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED19137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="296" mass="32420" checksum="1C62FD01C6130732" modified="2009-03-03" version="1">MSFGTVEADGSGEEVVNGTVHQDTVSLDGTELSVSSQSLGAITMTSPPGPAFPHDGLMGFFVPGSSFGESTNNWFTNLCSQPHALDECRFGLALELFTNNMNKHDGALYLGGAEHSRFLGELSVTEKHERFVFGDVIFDNQTIHSNAEIMVDSGTTVIWGPIKYVQELFDKAGMQSVLRQSNNTGSLVRTLDGFYSCDHPPSFGFQFPSLANATTARLRKSTVVSHQSRVFQIYYSALAENSSEDGGNCRASIHGTDSFGDSWIVGQRFFRGRYIDHNVEENTMGFADLQEIKKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4E7</accession>
    <name>B8M4E7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nonribosomal peptide synthase, putative</fullName>
            <ecNumber evidence="5">6.3.2.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_024640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.2.26" evidence="5"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479576.1">
        <property type="nucleotide sequence ID" value="XM_002479531.1"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_60_6_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050564">
        <property type="term" value="F:N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:phosphopantetheine binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
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        <property type="term" value="P:secondary metabolite biosynthetic process"/>
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        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Non-ribosomal peptide synthetase"/>
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        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
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    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003417">
        <property type="entry name" value="PRK04813.1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="781"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="1865"/>
            <end position="1941"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="2948"/>
            <end position="3024"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="4026"/>
            <end position="4099"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="5125"/>
            <end position="5201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED19142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="5650" mass="625696" checksum="EC462034BB40EA36" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4M5</accession>
    <name>B8M4M5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Very long-chain fatty acid transport protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Very-long-chain acyl-CoA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TSTA_025370</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Acyl-CoA synthetase required for both the import of long chain fatty acids (LCFAs) (C14-C18) and the activation very long chain fatty acids (VLCFAs) (C20-C26) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. The transport and fatty acyl-CoA synthetase activities are genetically separable and are thus independent activities. Esterifies VLCFAs in the peroxisome matrix. The VLCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479654.1">
        <property type="nucleotide sequence ID" value="XM_002479609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4M5"/>
    <dbReference type="FunCoup" id="B8M4M5">
        <property type="interactions" value="131"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M4M5"/>
    <dbReference type="GeneID" id="8106754"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_025370"/>
    <dbReference type="eggNOG" id="KOG1179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_46_3_1"/>
    <dbReference type="InParanoid" id="B8M4M5"/>
    <dbReference type="OMA" id="HHGLIMR"/>
    <dbReference type="OrthoDB" id="196650at2759"/>
    <dbReference type="PhylomeDB" id="B8M4M5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000019">
        <property type="entry name" value="Long-chain fatty acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF6">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY PROTEIN (CEFD1), PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="20">
        <location>
            <begin position="61"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EED19220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="626" mass="70667" checksum="1DEA0FAFB04EE052" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4N3</accession>
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            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="8" type="ORF">TSTA_025450</name>
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    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
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    <dbReference type="GeneID" id="8107957"/>
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    <dbReference type="eggNOG" id="ENOG502TG0X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1058364_0_0_1"/>
    <dbReference type="InParanoid" id="B8M4N3"/>
    <dbReference type="OMA" id="THIEIHA"/>
    <dbReference type="OrthoDB" id="4682787at2759"/>
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    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="129"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED19228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="263" mass="29576" checksum="DB97A61F081DFB86" modified="2009-03-03" version="1">MRSRGLSGSGDPRRWRCVEALSTAGDNKAFYGLIKNKEYHLTILTQILQCGVGFYITTLLLVEAAILLQWIRLFAPEGTRRAFYVCKFRSRDFLRQLANPSIVERLVGLPKRTMDQPLILSFSPVAGNLICIPFKRIWDKTVPGDFYNGRPLNMTIGAFNLLSDIFILILPQGVIWRMTLSRKEKIGVAARASAAFRLGIAVVYMIDPDRLYRASSLSMTYIAKMTCILLVYCMPGIPQSVQRLGHLVKGRGLIPIIHQLGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8M583</accession>
    <name>B8M583_TALSN</name>
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        <submittedName>
            <fullName evidence="7">Efflux pump antibiotic resistance protein, putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">TSTA_029630</name>
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    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002480078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M583"/>
    <dbReference type="FunCoup" id="B8M583">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="GeneID" id="8106530"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_029630"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="InParanoid" id="B8M583"/>
    <dbReference type="OMA" id="RVAGQQM"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="PhylomeDB" id="B8M583"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF201">
        <property type="entry name" value="MFS AFLATOXIN EFFLUX PUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="49"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED19689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="562" mass="59948" checksum="75FA39F0E8892A38" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5Q0</accession>
    <name>B8M5Q0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutaminase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_032030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480378.1">
        <property type="nucleotide sequence ID" value="XM_002480333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5Q0"/>
    <dbReference type="STRING" id="441959.B8M5Q0"/>
    <dbReference type="GeneID" id="8099816"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_032030"/>
    <dbReference type="eggNOG" id="ENOG502QPQS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008020_1_0_1"/>
    <dbReference type="InParanoid" id="B8M5Q0"/>
    <dbReference type="OMA" id="WTGYLVR"/>
    <dbReference type="OrthoDB" id="431715at2759"/>
    <dbReference type="PhylomeDB" id="B8M5Q0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="GtaA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF12">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877419" evidence="1">
        <location>
            <begin position="20"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="3">
        <location>
            <begin position="122"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="2">
        <location>
            <begin position="354"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="2">
        <location>
            <begin position="534"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="2">
        <location>
            <begin position="675"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED19944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="821" mass="91641" checksum="0DC020842B0926A5" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6N9</accession>
    <name>B8M6N9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CAIB/BAIF family enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_027920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479935.1">
        <property type="nucleotide sequence ID" value="XM_002479890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6N9"/>
    <dbReference type="STRING" id="441959.B8M6N9"/>
    <dbReference type="GeneID" id="8108308"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_027920"/>
    <dbReference type="eggNOG" id="KOG3957">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033975_0_1_1"/>
    <dbReference type="InParanoid" id="B8M6N9"/>
    <dbReference type="OMA" id="IIAGPYC"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="PhylomeDB" id="B8M6N9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047369">
        <property type="term" value="F:succinate-hydroxymethylglutarate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050483">
        <property type="entry name" value="CoA-transferase_III_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207:SF3">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="448" mass="48763" checksum="B4149745D632D5C9" modified="2009-03-03" version="1">MKARAILSQGILANRAIRLSTTPKGGYGVQWRRYSAAAAAPGILPLEGIRVLDMTRVLAGPYCTQILGDLGADVIKIEHPQRGDDTRAWGPPFAKYQDGSKKGPGESAYYLAVNRNKKSIGLSFAHTSGVEILHKLVKECDVLVENYLPGSLKKYAMDYETLSKINPKLIYASITGYGQTGPYRNRAGYDVMVEAEFGLMHITGSRDGPPVKVGVAVTDLTTGLYTSNAIMAAIIARGRTGKGQHIDACLSDVQVATLANLASSALISGEKDSGRWGTAHPSIVPYRSYKTLDGDILFGGGNDRLFGVLSDRLEHPEWKTDDRFVKNSNRVANRVELDGMIEEITKTKTTQEWLGLFEGSGMPYAAVNDIQGTLNHEHVRARGMVTEIEHPECGPMKLVNTPIKYSHAKPGVRTPPPTLGQHTDEVLQGLLDYSKDEILSLKQEGVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8M787</accession>
    <name>B8M787_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CHY and RING finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_035340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480741.1">
        <property type="nucleotide sequence ID" value="XM_002480696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M787"/>
    <dbReference type="STRING" id="441959.B8M787"/>
    <dbReference type="GeneID" id="8107484"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_035340"/>
    <dbReference type="eggNOG" id="KOG1940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013368_4_3_1"/>
    <dbReference type="InParanoid" id="B8M787"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="PhylomeDB" id="B8M787"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16464">
        <property type="entry name" value="RING-H2_Pirh2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039512">
        <property type="entry name" value="RCHY1_zinc-ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017921">
        <property type="entry name" value="Znf_CTCHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037275">
        <property type="entry name" value="Znf_CTCHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319:SF0">
        <property type="entry name" value="AND RING FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08900)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319">
        <property type="entry name" value="RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14599">
        <property type="entry name" value="zinc_ribbon_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161245">
        <property type="entry name" value="Zinc hairpin stack"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51270">
        <property type="entry name" value="ZF_CTCHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="7">
        <location>
            <begin position="396"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="CTCHY-type" evidence="8">
        <location>
            <begin position="465"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="532"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="190"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="294"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="681"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="765"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="681"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="783"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED20307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="811" mass="92111" checksum="4B6079115C7545AF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7Q7</accession>
    <name>B8M7Q7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_030520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480220.1">
        <property type="nucleotide sequence ID" value="XM_002480175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7Q7"/>
    <dbReference type="GeneID" id="8101731"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_030520"/>
    <dbReference type="eggNOG" id="ENOG502SIGA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016509_0_0_1"/>
    <dbReference type="InParanoid" id="B8M7Q7"/>
    <dbReference type="OMA" id="DWCRVHR"/>
    <dbReference type="OrthoDB" id="2283488at2759"/>
    <dbReference type="PhylomeDB" id="B8M7Q7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR ASQA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED19786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="767" mass="86608" checksum="9759832A6984C464" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8H0</accession>
    <name>B8M8H0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_037040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480917.1">
        <property type="nucleotide sequence ID" value="XM_002480872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8H0"/>
    <dbReference type="GeneID" id="8100550"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_037040"/>
    <dbReference type="eggNOG" id="ENOG502SRBG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152044_1_0_1"/>
    <dbReference type="InParanoid" id="B8M8H0"/>
    <dbReference type="OMA" id="GEHISTK"/>
    <dbReference type="OrthoDB" id="5235678at2759"/>
    <dbReference type="PhylomeDB" id="B8M8H0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="99" mass="10950" checksum="C1623A493E3A9324" modified="2009-03-03" version="1">MAPNKIISSQLIKTVANHGKNIKVKYATKTETWERTFLASSVQDDFSKAIEKTDDIPSGATTAILAEKEHPSSSDSKSHFTTVFENDDGEHISTKHVYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8H8</accession>
    <name>B8M8H8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_037120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480925.1">
        <property type="nucleotide sequence ID" value="XM_002480880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8H8"/>
    <dbReference type="STRING" id="441959.B8M8H8"/>
    <dbReference type="GeneID" id="8100558"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_037120"/>
    <dbReference type="eggNOG" id="ENOG502SXGD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059944_0_0_1"/>
    <dbReference type="InParanoid" id="B8M8H8"/>
    <dbReference type="OMA" id="TIWCGHD"/>
    <dbReference type="OrthoDB" id="4526074at2759"/>
    <dbReference type="PhylomeDB" id="B8M8H8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="379" mass="43229" checksum="F411C6A7D99D3543" modified="2009-03-03" version="1">MTQNMLDQLDMLYLTLFQLDDIDDQLCSTLQSKLAALGDQIPILQRLASYSKLVKQGSDLPVRRINYNIKKLSESCKPRWNEILKLNCEAIIFFMIAFNGLSSLPDQEFSWLARNLENYVEKRAFPAHWILREQIRKVVSNTPRKDNTKAFLAKYNVEEMKWCEDPAAIDPIQSVVDNRVDDKISSCKGVGGVDVEEHGKNAHPLQDDTDLEPTVQKATSTTSYESDLNVFSHAPPLTASASLQQVMTTEHHQQDVVQHTRKHTTESVTHEDEDRQEKIKLIKRSNEIDYKGSAMPASNLPLLIQRLPTAMEGSKQWKWERKFFANNVMRPREVGIDRTDCLSVFVPKDRNHDVSITLVVGYEAGVALIYDMGAQIIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8I8</accession>
    <name>B8M8I8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_037210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480935.1">
        <property type="nucleotide sequence ID" value="XM_002480890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8I8"/>
    <dbReference type="GeneID" id="8100567"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_037210"/>
    <dbReference type="eggNOG" id="ENOG502SGJJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_607172_0_0_1"/>
    <dbReference type="InParanoid" id="B8M8I8"/>
    <dbReference type="OrthoDB" id="5329403at2759"/>
    <dbReference type="PhylomeDB" id="B8M8I8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="50036" checksum="7E88D1C90B1C7A6E" modified="2009-03-03" version="1">MFAPDIVPINTPIGGLREYAASDPGGWTTEVRVGESPREVPPSWPMPPHMVDVFASGKYSDAKIQLSSANESDPFPTTILDVHRVVVSQSPVVGAILERESMPQTTVHIIAGESFSAPRGFELALQHLYGLELLGLGNVYNFAHQILGVEVVDGYTPDKLKKTAMDLALAYGATGAFLNQPDVVDAAFKLVVGLFDWSNLETALQFGLFPEEFLLAWIPLKNIAKEDTNSSSSSSSNNKDSKGKRKKRRSIRGKRAHKKTVVIDNLNTELVEKYAPRVASATIDFLVQNLPSNFFFDRAALANDLHDRIPVHLRSMYSLSNMNPLLATLQFGDFPIPTPECTHASAIFLALPFAHLREATEKMRNSGILTKDIIKAILQEREERRLTALEKHAEYTYNKGDDIDSMVNELGYHEFAVHLEGFEVSSGVGVTQYEYSLNREWQGLWPEGDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8MB68</accession>
    <name>B8MB68_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pescadillo homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Nucleolar protein 7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NOP7</name>
        <name evidence="7" type="ORF">TSTA_125690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pescadillo family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
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        <location>
            <begin position="485"/>
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        <location>
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        <location>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="673" mass="76048" checksum="C16A9C6B85972F1E" modified="2009-03-03" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
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    </dbReference>
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        <location>
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            <end position="303"/>
        </location>
    </feature>
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        <location>
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        <location>
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        <location>
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        <location>
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            <end position="61"/>
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        <location>
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    </feature>
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        <location>
            <begin position="748"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="770"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED18242.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="861" mass="95468" checksum="781205DCFFC9593D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCJ4</accession>
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        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="16" type="ORF">TSTA_125260</name>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
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    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
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            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
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            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
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        </reaction>
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            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="12">Binds 1 Ca(2+) ion per subunit.</text>
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        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
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        <property type="protein sequence ID" value="EED18810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002482757.1"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_125260"/>
    <dbReference type="eggNOG" id="ENOG502QTN1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013783_4_0_1"/>
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    <dbReference type="PhylomeDB" id="B8MCJ4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Peptidase_S8/S53_dom"/>
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        <property type="entry name" value="S53_propep"/>
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        <property type="entry name" value="Sedolisin_dom"/>
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        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
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        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF19">
        <property type="entry name" value="SERINE PROTEASE AORO, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
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</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="614" mass="68490" checksum="21F187076ABD63AF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCR8</accession>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED18970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="42" mass="4765" checksum="4B5945DF1C95A286" modified="2009-03-03" version="1">MDVLVGSYQTETPESLTDGQTEILNRIIEGYLRAFTSLEQMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCW5</accession>
    <name>B8MCW5_TALSN</name>
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            <fullName evidence="13">HAUS augmin-like complex subunit 1</fullName>
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    </protein>
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        <name evidence="11" type="ORF">TSTA_113170</name>
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    <organism evidence="11 12">
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAUS1 family.</text>
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        <property type="protein sequence ID" value="EED17491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002481438.1"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068908_0_0_1"/>
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    <dbReference type="OrthoDB" id="5372507at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:HAUS complex"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026243">
        <property type="entry name" value="HAUS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570:SF1">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25762">
        <property type="entry name" value="HAUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="192"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED17491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="32976" checksum="7BC37E09BE9C4DB7" modified="2009-03-03" version="1">MESLISPTKARQAAIQAKDWAYVNSWLNRKYAPNQVPPFERNEDTLRTLLAIAAANDAADEEASLLHRARKDVLRALKQRETAEDPRKRDILDDIEARLDSQGEESLNDLAETVVLLGDSSTDVTELAHAFIELTRDEFELANQVQHVEALQKYLHKEMALVQEEIETLKTHSAYKTPSDLTSQTVEWARSAKLLNAKISEYRERISSLQRSLRVDGPTIETVEQEEENVLRLRETVKQLESRIKSYRDLPPDLDDARNEYRRLEKELGRLTRERDNLFERAVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCZ1</accession>
    <name>B8MCZ1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8035 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_113430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481509.1">
        <property type="nucleotide sequence ID" value="XM_002481464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCZ1"/>
    <dbReference type="STRING" id="441959.B8MCZ1"/>
    <dbReference type="GeneID" id="8101655"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_113430"/>
    <dbReference type="eggNOG" id="ENOG502SM5I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018248_0_0_1"/>
    <dbReference type="InParanoid" id="B8MCZ1"/>
    <dbReference type="OMA" id="MIDPMRA"/>
    <dbReference type="OrthoDB" id="5418088at2759"/>
    <dbReference type="PhylomeDB" id="B8MCZ1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42081">
        <property type="entry name" value="ZINC FINGER PROTEIN DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42081:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26118">
        <property type="entry name" value="DUF8035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8035" evidence="2">
        <location>
            <begin position="541"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED17517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="664" mass="76073" checksum="2F98B1F74000DA6F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8MD57</accession>
    <name>B8MD57_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_113970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481574.1">
        <property type="nucleotide sequence ID" value="XM_002481529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MD57"/>
    <dbReference type="STRING" id="441959.B8MD57"/>
    <dbReference type="GeneID" id="8109159"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_113970"/>
    <dbReference type="eggNOG" id="ENOG502SSAT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071361_1_0_1"/>
    <dbReference type="InParanoid" id="B8MD57"/>
    <dbReference type="OMA" id="VYEIMPE"/>
    <dbReference type="OrthoDB" id="4364812at2759"/>
    <dbReference type="PhylomeDB" id="B8MD57"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED17582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="269" mass="31088" checksum="9E88840A6A01D288" modified="2009-03-03" version="1">MGRVARRAIPNCTFPLPAILLRKIANVPQRYWDFAATESFDQQRLRRIRQFIDLDEIPREWDPVNYGAPPPCMPTAEEIDTVLRPWRSDELRQKAWEILESGNVAPIFLRTHYDPDDEKMEEWQRVYDITPEVAGPVSGAGYKRYPSPEIVETSRTQFKTSLSKSKQEPDRWREDPHRFIELEAADLLRTVAAAYILVADQEAFETGGQLRLTRVEADAQTITDVIMDWDQLNLPPDLWEEGTIGDRYHVTGDLGRELYQLSEADMADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MD83</accession>
    <name>B8MD83_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tyrosine-protein phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_114210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481600.1">
        <property type="nucleotide sequence ID" value="XM_002481555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MD83"/>
    <dbReference type="STRING" id="441959.B8MD83"/>
    <dbReference type="GeneID" id="8109183"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_114210"/>
    <dbReference type="eggNOG" id="ENOG502S0PE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057546_1_3_1"/>
    <dbReference type="InParanoid" id="B8MD83"/>
    <dbReference type="OMA" id="HTIFDFR"/>
    <dbReference type="OrthoDB" id="449382at2759"/>
    <dbReference type="PhylomeDB" id="B8MD83"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF1">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="1">
        <location>
            <begin position="163"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="306" mass="33734" checksum="D54DD69FC81FB64F" modified="2009-03-03" version="1">MACVDLLTNHGQMVPEDPTSKMSVAAQVTAAAAPSTPSPPFIHVDGVPNFRDIGGYPITSSTSIRRNFIYRSALPTRITPTGLQKLTQDLRITTVYDLRSNAELRKDPITSSPLDNHEAVKVLHAPVFPERDSSPEQLAKRFANYMSVNGSEGFVAAYAEILRDGVNAYRAIFEHVRDRPRDAFLVHCTGGKDRTGVLVALLLLVAGVQDRDMIAHEYSLTEKGFDASVKAHLTDKIIKDMGMDPENRAGIERLLSARKENMSATIEYIERQFGGAEGYLKGELGFGDDDVERIRKSLVVEDKGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8ME20</accession>
    <name>B8ME20_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_012060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483331.1">
        <property type="nucleotide sequence ID" value="XM_002483286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ME20"/>
    <dbReference type="STRING" id="441959.B8ME20"/>
    <dbReference type="GeneID" id="8104054"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_012060"/>
    <dbReference type="eggNOG" id="ENOG502SIWZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026656_0_0_1"/>
    <dbReference type="InParanoid" id="B8ME20"/>
    <dbReference type="OrthoDB" id="2563500at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF7">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED16097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="45453" checksum="C9D022DCD53F78E3" modified="2009-03-03" version="1">MMQMMSLQTFDRTYSSNLTSNLRLSPLLSRETLRRLAWSTFYNDTIIDGGRYGFHTIDEKAYSIQLACDEASFLRNENVVTGPLRCNASVSANADSSNKSEEQLLDISDYLLRTAAARRRALHFAFRASHAEQTSEELTTELATIEHDMEEVINALPKEFHFNSSNMLLHRHRLITFILLHVIRHNLFIITGRAALHIYSQDNSTKADLISQIRRNRISHALPTARIVAEGLRAGIYFDPDVAVDAYVALESQDPAEYDFRDFRWAKLERLRRCTTTSTNTRPSSIKTSFSDESLLEYMTDSDTVLPSLPPLDASDVYKTHPQAASVSYPVSLGSIPTSSAKGHALPIGQGSDDYNLNQPPIPPWYGSAAEAGDGLYSLDWSWFLDELGLEYQSGDSGMSLGLLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEN7</accession>
    <name>B8MEN7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_019810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484154.1">
        <property type="nucleotide sequence ID" value="XM_002484109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEN7"/>
    <dbReference type="GeneID" id="8108792"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_019810"/>
    <dbReference type="HOGENOM" id="CLU_1939537_0_0_1"/>
    <dbReference type="InParanoid" id="B8MEN7"/>
    <dbReference type="OrthoDB" id="5772781at2759"/>
    <dbReference type="PhylomeDB" id="B8MEN7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED16920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="130" mass="14790" checksum="353C7BE90E5BECFF" modified="2009-03-03" version="1">MATRERVWDKPIPVPEKLAKSWALLDVDRATGRALRILIEQVDGSYPTFFLKVNKAVLILNLHKQPGEHLQRTKDTHFDLCEFVEMNEEIPEPQERGKGLAQLHKNALSPNAKYGFAVPTVQGTIPQYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MF86</accession>
    <name>B8MF86_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxalate decarboxylase oxdC, putative</fullName>
            <ecNumber evidence="7">4.1.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_012920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.2" evidence="7"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483419.1">
        <property type="nucleotide sequence ID" value="XM_002483374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MF86"/>
    <dbReference type="STRING" id="441959.B8MF86"/>
    <dbReference type="GeneID" id="8108168"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_012920"/>
    <dbReference type="eggNOG" id="ENOG502QQ0P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030515_1_1_1"/>
    <dbReference type="InParanoid" id="B8MF86"/>
    <dbReference type="OMA" id="HARTFNY"/>
    <dbReference type="OrthoDB" id="10263073at2759"/>
    <dbReference type="PhylomeDB" id="B8MF86"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046564">
        <property type="term" value="F:oxalate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20305">
        <property type="entry name" value="cupin_OxDC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20304">
        <property type="entry name" value="cupin_OxDC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF9">
        <property type="entry name" value="SLL1358 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002875065" evidence="5">
        <location>
            <begin position="18"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="6">
        <location>
            <begin position="116"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="6">
        <location>
            <begin position="293"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="71"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED16185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="458" mass="51540" checksum="D083FBF223042567" modified="2009-03-03" version="1">MHKSILLSLGLLLVATANPVPNENIQRLSKIPASSSQEYFFGGDQTGTSRPFTPGHQDPYDRKVDPVGDDLEPLPYRNGDGATVMGPRNRDRERQNPDLVRPPSTDHGTLSNMRWSFADSHTRIEEGGWTRQTTIRELPTSKELAGVNMRLDTGVIRELHWHKEAEWAFMLSGNARVTGLDTEGGSFIDDVEAGDLWYWPPGHPHSIQGLGPNGTEFLLIFDDGNFSEDSTFLLSDWMAHTPKSVLSENFRIPPEIFNSIPKSEKYIFQGSKPGSISAEKPKGFKKSTKSFTHKMLAQEPEITSSGGEVRITDSKRNFPISKSVAAAHLKINPGAIREMHWHPHADEWSYFIRGRARVTVFAAEGNARTFDYMAGDVGIVPKNMGHFVENLSDDEPLEMLEIFRADEFLDFSLFQWLGETPQRLVAEHVFKDDKKAAKMLLEQIEGGEKDPIKEKFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MF93</accession>
    <name>B8MF93_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endosomal/vacuolar adapter protein YPT35</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PX domain-containing protein YPT35</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_012990</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Recruits the lipid transfer protein VPS13 to endosomal and vacuolar membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YPT35 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483426.1">
        <property type="nucleotide sequence ID" value="XM_002483381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MF93"/>
    <dbReference type="STRING" id="441959.B8MF93"/>
    <dbReference type="GeneID" id="8108175"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_012990"/>
    <dbReference type="eggNOG" id="ENOG502S5IQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070610_0_1_1"/>
    <dbReference type="InParanoid" id="B8MF93"/>
    <dbReference type="OMA" id="LAYFLNC"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="PhylomeDB" id="B8MF93"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07280">
        <property type="entry name" value="PX_YPT35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037917">
        <property type="entry name" value="Ypt35_PX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="135"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED16192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="248" mass="27402" checksum="E153AA280B6E0457" modified="2009-03-03" version="1">MEHTPDDETGSSERSAQPAPVEEANPDENNNADNDNSIRDVSEPTSDEIASTASISEHHPNNTNGTAHHNPDTNKPRKDRPVSGVVPPYWRHHRALSRASLASVDTHHSSSKPAITLEDHTADPDATTTKGLWARSVTIDDHVVVSGKTGIGAYVVWMCNVQTLDGGPMMIPMRYSEFDELRLLLSKAFPQSTNALPPLPPKSVLFKFRPKFLESRRIGLQYFLNCVLLNPEFAGSPVLKDFLFSRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFC2</accession>
    <name>B8MFC2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_017310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483890.1">
        <property type="nucleotide sequence ID" value="XM_002483845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFC2"/>
    <dbReference type="STRING" id="441959.B8MFC2"/>
    <dbReference type="GeneID" id="8103704"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_017310"/>
    <dbReference type="HOGENOM" id="CLU_2814166_0_0_1"/>
    <dbReference type="InParanoid" id="B8MFC2"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="PhylomeDB" id="B8MFC2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED16656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="67" mass="7604" checksum="6807962930A75F78" modified="2009-03-03" version="1">MWPCDEQEQDRLDLLHKVITEARIGDGLLYAPHPSNARVLDLGCGTGIRIGCSLHWDSTRDRYSYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFM7</accession>
    <name>B8MFM7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dimethylaniline monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_020740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484251.1">
        <property type="nucleotide sequence ID" value="XM_002484206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFM7"/>
    <dbReference type="FunCoup" id="B8MFM7">
        <property type="interactions" value="648"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MFM7"/>
    <dbReference type="GeneID" id="8109336"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_020740"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006909_5_0_1"/>
    <dbReference type="InParanoid" id="B8MFM7"/>
    <dbReference type="OMA" id="HSAWYRT"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="PhylomeDB" id="B8MFM7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000138">
        <property type="entry name" value="Flavin-containing monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED17017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="478" mass="53930" checksum="A92E757BBDD29B50" modified="2009-03-03" version="1">MCADVVENGDDDFKIDRIAIIGAGAAGLAAATYISGEQQFSHIEVFEQRSSAGGTWNYSSAKRVPGLAVPKTTPDHNNETPSQPTSVDDDGFVSPLYRDLDTNIPHNLMNFSNKPFPEGSSLFPSRDVVTEYLHQYAESLKHMIHYNTQVRKITKINMGEKEFWNLDTENLKSHETGTSFFDAVVIANGHYSDVHIPDITGIKEFHQRYPEIISHSKYYEKPENFEDKKVIVVGFSASGLDISMQIAQSCRHPVLVSEKTPSLLDPSETGPNLRMMPTIEEFLVDKRAVRFSNGHVETDVDSVIFCTGYLYSFPFLESLRQSLTPDGSYVRHLYQHLFFIDDPTLAFVALPKRIVPFPVSESQSAYIARVWANRAKLPANPVMREWEASLVASCPEPSSLHDMKYPKDADYINKLHEICKATANGVNLIPPRWDEEACYYREHMAQIKSISRKLGHSRRLVKSLSELGFEYPVNQSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFV9</accession>
    <name>B8MFV9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_009480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483060.1">
        <property type="nucleotide sequence ID" value="XM_002483015.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MFV9"/>
    <dbReference type="GeneID" id="8102744"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_009480"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002055_0_0_1"/>
    <dbReference type="InParanoid" id="B8MFV9"/>
    <dbReference type="OrthoDB" id="4368291at2759"/>
    <dbReference type="PhylomeDB" id="B8MFV9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="662"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="933"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="944"/>
            <end position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED15826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1583" mass="178379" checksum="FC84D633156CBD6B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFY8</accession>
    <name>B8MFY8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_009750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483089.1">
        <property type="nucleotide sequence ID" value="XM_002483044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFY8"/>
    <dbReference type="STRING" id="441959.B8MFY8"/>
    <dbReference type="GeneID" id="8102771"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_009750"/>
    <dbReference type="eggNOG" id="KOG3043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_0_0_1"/>
    <dbReference type="InParanoid" id="B8MFY8"/>
    <dbReference type="OrthoDB" id="2147163at2759"/>
    <dbReference type="PhylomeDB" id="B8MFY8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668:SF1">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G01940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED15855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="25635" checksum="ED9EF06FCDB34BAD" modified="2009-03-03" version="1">MASETPKDVFMAFIRESYNPCGSEETIGGLKTYVTGRRDATVGVVDVYDVFGISNHTQQGADLVASVPDLLKGTYAKPEWFPLNSDEKRAQFFGLLKGYAAPHKFVDPSLEFMRHVRSRFPIVTKWGSFGLCWGGKGETYPYSFTPNDPRSDPVDVFSMLDPAEAKKITIFHLVMASKDEPSEAVADFKTVIEENGIGRYLPTYTTMHHSWPGLKANLVEEGTFVGYRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8MG56</accession>
    <name>B8MG56_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldo/keto reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_010410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483157.1">
        <property type="nucleotide sequence ID" value="XM_002483112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MG56"/>
    <dbReference type="STRING" id="441959.B8MG56"/>
    <dbReference type="GeneID" id="8105680"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_010410"/>
    <dbReference type="eggNOG" id="ENOG502SMNT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_1_1_1"/>
    <dbReference type="InParanoid" id="B8MG56"/>
    <dbReference type="OMA" id="GAVYRMW"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="PhylomeDB" id="B8MG56"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED15923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="312" mass="34021" checksum="4BD10E0CF06F9E17" modified="2009-03-03" version="1">MPPTLFYGTAIFGTPTIPSLTEPEGVSKLLDSVHSLDITELDTAARYPPDNTGGSERLLGATRAGSNFTINTKVLISGTSGDGSLSKDAVRASVANSLRTLGVSNVGILYAHAPDNATPLEEQAKDFNEQYEKGYCERIGVSNFPLDMLEKFLKICDECNYIKPSVYQGEYNLIRRDPEEAIFPLLRRHKIHFVAYSPLGGGFLTGKLTAGNTEGTRFDGPLGQRFKALYDKPELHASINELKRITEPLGISPTAAALRWLAHHSELRQEDGIILGASKIEQLRQNVKDIKQGPLPESVVEAIRAIKVATTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGH0</accession>
    <name>B8MGH0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_013890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483524.1">
        <property type="nucleotide sequence ID" value="XM_002483479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGH0"/>
    <dbReference type="STRING" id="441959.B8MGH0"/>
    <dbReference type="GeneID" id="8099188"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_013890"/>
    <dbReference type="eggNOG" id="KOG0257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_4_1"/>
    <dbReference type="InParanoid" id="B8MGH0"/>
    <dbReference type="OMA" id="IMAARDY"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="PhylomeDB" id="B8MGH0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510:SF1">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="59"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED16290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="412" mass="45812" checksum="5867C343AA7E9897" modified="2009-03-03" version="1">MVKIEPFAVEQWMDDHETTATYNIAETCCASISLDDLQNLSTQQPDPNNQNSIFSFSRSTKLAYGAIRGSEQLRGHLSRLYSIKTSTPLPADNVLITSGAIQGNFLLHHALVGPGDHVIVHYPTYQQLYSVVEAIGAEVSLWKAKEDDENGWVLDTEELKGLIRPNTKLIVLNNPQNPTGAIIPKSKLEEIVNIARSQSIIIHADEVYRPIFHGISPVDAEFPPSLLSLGYKNAVVTGSMSKAYSLAGIRVGWIASRNKEIIDRCMVFRDYTTISVSQIDDAVASFALAPHTIHSLLHRNIQLAKTNLAILEKFIESHRWACDWKKPLAGTTAFVRFSKMGRPVDDVAFCTLLHEKTGVLVVPGSRCFGRDGDFKGYVRIGYVSETEVLEKGLEKLREFMKGEYVDDVPLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MH57</accession>
    <name>B8MH57_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA-directed DNA polymerase theta, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_019340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484105.1">
        <property type="nucleotide sequence ID" value="XM_002484060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MH57"/>
    <dbReference type="STRING" id="441959.B8MH57"/>
    <dbReference type="GeneID" id="8104629"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_019340"/>
    <dbReference type="eggNOG" id="KOG0950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006553_2_0_1"/>
    <dbReference type="InParanoid" id="B8MH57"/>
    <dbReference type="OMA" id="MFLNANI"/>
    <dbReference type="OrthoDB" id="2320933at2759"/>
    <dbReference type="PhylomeDB" id="B8MH57"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18026">
        <property type="entry name" value="DEXHc_POLQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.20:FF:000005">
        <property type="entry name" value="DNA-directed DNA polymerase theta, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000968">
        <property type="entry name" value="Helicase and polymerase-containing protein TEBICHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057220">
        <property type="entry name" value="DUF7898"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046931">
        <property type="entry name" value="HTH_61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048960">
        <property type="entry name" value="POLQ-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF6">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25453">
        <property type="entry name" value="DUF7898"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20470">
        <property type="entry name" value="HTH_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21099">
        <property type="entry name" value="POLQ_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="167"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="416"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED16871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="946" mass="103844" checksum="DB6711A392C814E6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHB1</accession>
    <name>B8MHB1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein phosphatase methylesterase 1</fullName>
            <ecNumber evidence="2">3.1.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_021470</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Demethylates proteins that have been reversibly carboxymethylated. Demethylates the phosphatase PP2A catalytic subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48548"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="3.1.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.89" evidence="2"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484324.1">
        <property type="nucleotide sequence ID" value="XM_002484279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHB1"/>
    <dbReference type="FunCoup" id="B8MHB1">
        <property type="interactions" value="845"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MHB1"/>
    <dbReference type="ESTHER" id="talsn-b8mhb1">
        <property type="family name" value="PPase_methylesterase_euk"/>
    </dbReference>
    <dbReference type="GeneID" id="8107066"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_021470"/>
    <dbReference type="eggNOG" id="KOG2564">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024818_3_0_1"/>
    <dbReference type="InParanoid" id="B8MHB1"/>
    <dbReference type="OMA" id="VMVCHHG"/>
    <dbReference type="OrthoDB" id="194865at2759"/>
    <dbReference type="PhylomeDB" id="B8MHB1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051723">
        <property type="term" value="F:protein methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000186">
        <property type="entry name" value="Protein phosphatase methylesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016812">
        <property type="entry name" value="PPase_methylesterase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="9">
        <location>
            <begin position="130"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="30"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED17090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="425" mass="46579" checksum="A176E899FED3E13A" modified="2009-03-03" version="1">MDNMSDLQKAFVKAKLAKYPPDIPIFDETEEDATTSTGINRGNDATIEEGEEFDSSSTSSASSVGTVVPSPSRNLFAKPGSLPRQRNGSAESLTWRDFFSRELYIERNTDDLHIIYHTYITPPTGSGPLFVMHHGAGSSGLSFAACAAEIRKILPEAGILSLDARYHGSTTVESRDGNPVELDYRLETLSQDLLAVIRGAQTQMVWETLPDLVLVGHSLGGAVITDVARGGELGAKVLAYAVLDVVEGSAMDALQGMDTYLSARPTRFPSLSSAIEWHFRSRTIRNTTSARVSVPSLLTEEENPSDASLPWTWRTNLADTKPFWEDWFKGLSKKFLEAKGGKLLLLAGTDRLDKELMIAQMQGKFSLQVLPLAGHFIQEDQPAKTARFLVDFFKRNDRTPLVLPPKVGDIMASKAMEKGVGINKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHQ9</accession>
    <name>B8MHQ9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proline iminopeptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_014810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483623.1">
        <property type="nucleotide sequence ID" value="XM_002483578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHQ9"/>
    <dbReference type="STRING" id="441959.B8MHQ9"/>
    <dbReference type="ESTHER" id="talsn-b8mhq9">
        <property type="family name" value="Proline_iminopeptidase"/>
    </dbReference>
    <dbReference type="GeneID" id="8107864"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_014810"/>
    <dbReference type="eggNOG" id="ENOG502QSNW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024518_2_1_1"/>
    <dbReference type="InParanoid" id="B8MHQ9"/>
    <dbReference type="OrthoDB" id="1898734at2759"/>
    <dbReference type="PhylomeDB" id="B8MHQ9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF2">
        <property type="entry name" value="PROLYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="59"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED16389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="406" mass="45682" checksum="E507D3AFA79FC268" modified="2009-03-03" version="1">MDPIPPAQLLSKSEAHVRAVPLDYSKPESRTIRLFARTATRYSNPIVPSTAAKKVQPPFLVFFTGGPGAGNPAPQESPITSFMIDYGYDIVYLDYRGTGNSSPISAETLELIGGPTEQAQYPRLFRADALVKDCEVVRQCLTDNYPPELKKWTIFGQSFGGAVSLNYFSFYPEGVRECFITAGLGSLRTQPEELYARMYKRVIKRNKDYYAKYPADVGLVKDVASHIRKLGGQEGILLPTAGRLTVQRLMTLRLHFGGDGGFDRIHDLFTKLKADLDIYGFFTRPSLHAFEQSMTWDIVPIYAMHDSWMVNGPGIASNWTADRVGKTLGTFPWLAEDWQQSSDNEPLYFSGGMLYPFLFDTYAGLVKIKEAAQLIAKFDDWPYLYDEKQLAKNEFPYTLLALMICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8MI55</accession>
    <name>B8MI55_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_022710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484451.1">
        <property type="nucleotide sequence ID" value="XM_002484406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MI55"/>
    <dbReference type="GeneID" id="8107108"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_022710"/>
    <dbReference type="eggNOG" id="ENOG502SK11">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032923_1_0_1"/>
    <dbReference type="InParanoid" id="B8MI55"/>
    <dbReference type="OMA" id="REVTKQC"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="PhylomeDB" id="B8MI55"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED17217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="430" mass="48443" checksum="25F0E6CA55F6A95D" modified="2009-03-03" version="1">MADPLSVAASVLAVVTAAAQSTRSLYDTIRRFQDRSKTLRRLQDELEDLANILSSLAQVVTSETTMLELLQRPIDRCSQVCRDFEASMKTFSGKSKPGFRDWTKMEFMRGDINDFIDTIAEYKSTISVGLGTINLHTSKISHQALQEYNEMIQDTVYNLELRLRRIDEKMAQFPLNDCDASSTSIDLKDERAVTQQCIRVCKDARSYIESLISRDSSLLPHLHVSHNGSEDVQGISEAQQRTRQVLDESQSQFEDVIGHLQRRLQSLLLEREPNDTERLRLQEDIDISRQCLEVCKTASEVSRQKIYRVGEVVADGESDQVVVTTLADLFDVKKASSKGNSAQLVGSMTPENLRHLTEERYKSRFGALAANSDRVKTSSTGSLPGPEGERGKYESRNTSEQDELSSEPQARHIRPSSNEIRKRATGGDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIE2</accession>
    <name>B8MIE2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protease S8 tripeptidyl peptidase I, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_041050</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="9">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484579.1">
        <property type="nucleotide sequence ID" value="XM_002484534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIE2"/>
    <dbReference type="STRING" id="441959.B8MIE2"/>
    <dbReference type="MEROPS" id="S53.007"/>
    <dbReference type="GeneID" id="8099913"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_041050"/>
    <dbReference type="eggNOG" id="ENOG502QTN1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013783_4_0_1"/>
    <dbReference type="InParanoid" id="B8MIE2"/>
    <dbReference type="OMA" id="HIDYIVP"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="PhylomeDB" id="B8MIE2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
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    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED15658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="398" mass="44856" checksum="BF52170417F547FF" modified="2009-03-03" version="1">MGEVPPVSHRKYEAPRHGSLAYLPRKRAARHRGKVKSFPKDDPKKPVHLTASMGYKAGMTTIVRDLDRPGAKMHKKEVVEAVTVIETPPLVAVGVVGYIETPRGLRSLTTVWAEHLSDELKRRFYKNWYKSKKKAFTRYAKKHTESSAASVTRELERIKKYCTVVRVLAHTQIRKTPLKQKKAHLMEIQVNGGSVADKVDFAHGLFEKTIDIDTIFEQNEVIDVIAVTKGHGFNGVTSRWGTKKLPRKTHKGLRKVACIGAWHPNHVQWTVARAGQMGYHHRTSVNHKIYRIGKGSDEGNASTEYDVSKKTITPLGGFVRYGEVKNDFVIVKGSVPGVKKRVMTLRKTLYPQVSRKATEKIDLKWIDTSSEFGHGAYQTPAEKRAFMGTLKKDLVTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJ47</accession>
    <name>B8MJ47_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Polyketide synthase, putative</fullName>
            <ecNumber evidence="12">2.3.1.161</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_051450</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.161" evidence="12"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485662.1">
        <property type="nucleotide sequence ID" value="XM_002485617.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MJ47"/>
    <dbReference type="GeneID" id="8103367"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_051450"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_31_1_1"/>
    <dbReference type="InParanoid" id="B8MJ47"/>
    <dbReference type="OMA" id="VHTGCFT"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="PhylomeDB" id="B8MJ47"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050637">
        <property type="term" value="F:lovastatin nonaketide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="1"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="952"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="9">
        <location>
            <begin position="952"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="9">
        <location>
            <begin position="1109"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="9">
        <location>
            <position position="984"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="9">
        <location>
            <position position="1175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED15709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="2574" mass="283293" checksum="23AE4BEBA75F70B3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJ66</accession>
    <name>B8MJ66_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_041330</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484608.1">
        <property type="nucleotide sequence ID" value="XM_002484563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJ66"/>
    <dbReference type="GeneID" id="8109718"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_041330"/>
    <dbReference type="eggNOG" id="KOG1441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022332_0_2_1"/>
    <dbReference type="InParanoid" id="B8MJ66"/>
    <dbReference type="OMA" id="LGAEKCQ"/>
    <dbReference type="OrthoDB" id="6418713at2759"/>
    <dbReference type="PhylomeDB" id="B8MJ66"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="10">
        <location>
            <begin position="29"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED14655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="371" mass="40085" checksum="DD4F9290122A8756" modified="2009-03-03" version="1">MSNKASELPTTNQGAAAAAAKPAPALHPAVYIASWIALSSGVIIFNKWILHTAGFGYPLFLTTWHLFFATVMTQILARFTTVLDSRHKVPMTRSVYLRAIVPIGVFFSLSLIFGNLVYLYLSVSFIQMLKATNSVATLIATWALGVAPVRLETLGNVSVIVVGVVIASIGEIKFSLIGFIYQVFATVFESVRLVMVQRLLSSAEFKMDPLVSLYYFAPACMVMNGLATLVFEIPKMTMYDIRSVGVGNLVANASVAFALNVAVVFLIGKTSALVLTLSGVLKDILLVVASMVIFHDPVTPLQALGYGIALMGLIYYKLGAENVRQSLRGVGIRRSILFVLLGALFYFGLSQYTQNATVFSPSLLSGLGSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJZ1</accession>
    <name>B8MJZ1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_042810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484761.1">
        <property type="nucleotide sequence ID" value="XM_002484716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJZ1"/>
    <dbReference type="GeneID" id="8104758"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_042810"/>
    <dbReference type="eggNOG" id="ENOG502SP9G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_821603_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJZ1"/>
    <dbReference type="OrthoDB" id="3938867at2759"/>
    <dbReference type="PhylomeDB" id="B8MJZ1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="384" mass="43386" checksum="3D027A367D9B9149" modified="2009-03-03" version="1">MGTRSLICIWYKGRFMVAQYCQWDGYLEGQGLDILNFLLVPGNIDRLKQGLEYITIVDDKTIEDLVSGHTYSTHGENGKVCECGATDPWVGPSQWIPRTLSRDAGAKIFDIIAAAKVDDFVPIQLALEFAQDGLFCEYAYCVDLDAGVFEVFGGHVMNPKKESIGQMGEYRFAEACKDAKIMPKLLMSFLLTELPKNLKEFLGPIVKNNEEFQSDDDDDEGEDEEEEEDDHVDFDETDKSEGEDNAKAADDKAVDVKSYKTGGVKAVSAPEDKKLPDSREDKDKKEISHDIHDIERERELQKKIEEMTMDEVAREIERETERETERMMMEEIGKELENEKKRTARQGSAGSGDKKNPLNMSVQTGRLGRYRSGLVDYTNKPASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MK53</accession>
    <name>B8MK53_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mucin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_043450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484823.1">
        <property type="nucleotide sequence ID" value="XM_002484778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MK53"/>
    <dbReference type="STRING" id="441959.B8MK53"/>
    <dbReference type="GeneID" id="8097853"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_043450"/>
    <dbReference type="eggNOG" id="ENOG502QWSP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013431_2_0_1"/>
    <dbReference type="InParanoid" id="B8MK53"/>
    <dbReference type="OMA" id="GFKKWVT"/>
    <dbReference type="OrthoDB" id="442243at2759"/>
    <dbReference type="PhylomeDB" id="B8MK53"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF118">
        <property type="entry name" value="CYCLIN, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="649" mass="71526" checksum="BCECDA785947653B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKB4</accession>
    <name>B8MKB4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_047200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485222.1">
        <property type="nucleotide sequence ID" value="XM_002485177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKB4"/>
    <dbReference type="FunCoup" id="B8MKB4">
        <property type="interactions" value="1051"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MKB4"/>
    <dbReference type="MEROPS" id="T01.984"/>
    <dbReference type="GeneID" id="8098513"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_047200"/>
    <dbReference type="eggNOG" id="KOG0177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_12_0_1"/>
    <dbReference type="InParanoid" id="B8MKB4"/>
    <dbReference type="OMA" id="MKRDHDK"/>
    <dbReference type="OrthoDB" id="268428at2759"/>
    <dbReference type="PhylomeDB" id="B8MKB4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000008">
        <property type="entry name" value="Proteasome subunit beta type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED15269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="203" mass="22454" checksum="D83AFF00A9EDF242" modified="2009-03-03" version="1">MEVLLGITGKDFVIIAASKAAMRGPTVLKATDDKTRNLSQHTLMAFSGEPGDGVQFAEYIQANVQLYSMRNDSELSPAAVGNFVRGELARALRSRNPYTVNLLLGGVDAITNTPSLYWVDYLASLAQVPYAAHGYAQYYCLSILDKHHHPDIELEQGLKLLNLCTDELKRRLPIDFKGVLVKVVTKDGIQEIDYDNERKVAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKD0</accession>
    <name>B8MKD0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Enolase</fullName>
            <ecNumber evidence="4">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSTA_047340</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="4"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485238.1">
        <property type="nucleotide sequence ID" value="XM_002485193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKD0"/>
    <dbReference type="FunCoup" id="B8MKD0">
        <property type="interactions" value="1159"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MKD0"/>
    <dbReference type="GeneID" id="8099284"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_047340"/>
    <dbReference type="eggNOG" id="KOG2670">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031223_0_0_1"/>
    <dbReference type="InParanoid" id="B8MKD0"/>
    <dbReference type="OMA" id="RCMMSHR"/>
    <dbReference type="OrthoDB" id="1739814at2759"/>
    <dbReference type="PhylomeDB" id="B8MKD0"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.10:FF:000001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000002">
        <property type="entry name" value="Enolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00178">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="16">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="15">
        <location>
            <begin position="143"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="374"/>
            <end position="377"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EED15285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="438" mass="47289" checksum="A2F8C68181011B0C" modified="2009-03-03" version="1">MPISKIHARSVYDSRGNPTVEVDVVTETGLHRAIVPSGASTGQHEACELRDGDKTKWGGKGVLKAVANVNETIGPAIIKENIDVKDQSKVDEFLIKLDGTANKTNLGANAILGVSLAIAKAGAAEKGVPLYAHISDLAGTKKPYVLPVPFQNVLNGGSHAGGRLAFQEFMIVPSTAPTFSEGLRQGAEVYQKLKALAKKKYGQSAGNVGDEGGVAPDIQTAEEALDLITEAIEQAGYTGKIKIAMDVASSEFYKADVKKYDLDFKNPDSDPSKWLTYEQLADLYKNLAKKYPIVSIEDPFAEDDWEAWSYFFKTSDFQIVGDDLTVTNPLRIKKAIELKSCNALLLKVNQIGTLTESIQAAKDSYAGGWGVMVSHRSGETEDVTIADIVVGLRSGQIKTGAPARSERLAKLNQILRIEEELGENAIYAGEKFRDAVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKG2</accession>
    <name>B8MKG2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_047630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485270.1">
        <property type="nucleotide sequence ID" value="XM_002485225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKG2"/>
    <dbReference type="STRING" id="441959.B8MKG2"/>
    <dbReference type="GeneID" id="8099313"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_047630"/>
    <dbReference type="HOGENOM" id="CLU_1897606_0_0_1"/>
    <dbReference type="InParanoid" id="B8MKG2"/>
    <dbReference type="OrthoDB" id="4509585at2759"/>
    <dbReference type="PhylomeDB" id="B8MKG2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="134" mass="15092" checksum="BC1C90931E9E7A94" modified="2009-03-03" version="1">MIIFCDSQATIQAINGAQKTGQQILGSIAEKWDELRSQGVQVTIHWILAHQGIKGNERADIAAKEATRWRLASIIYPNTDADRFKEERNAWKNEGTWSSDARKILSKGKYTVRAAKFMLKTKLLGQFGSIDLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKI6</accession>
    <name>B8MKI6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">GATA transcriptional activator AreA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_047870</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485294.1">
        <property type="nucleotide sequence ID" value="XM_002485249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKI6"/>
    <dbReference type="STRING" id="441959.B8MKI6"/>
    <dbReference type="GeneID" id="8099337"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_047870"/>
    <dbReference type="eggNOG" id="KOG1601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009509_0_0_1"/>
    <dbReference type="InParanoid" id="B8MKI6"/>
    <dbReference type="OMA" id="WRMMAMS"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="PhylomeDB" id="B8MKI6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="11">
        <location>
            <begin position="624"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="96"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="435"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="555"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="691"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="756"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="435"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="700"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="723"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="788"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED15341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="863" mass="92796" checksum="686B0A970ABDDB78" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8ML40</accession>
    <name>B8ML40_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_048960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485409.1">
        <property type="nucleotide sequence ID" value="XM_002485364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ML40"/>
    <dbReference type="STRING" id="441959.B8ML40"/>
    <dbReference type="GeneID" id="8100612"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_048960"/>
    <dbReference type="HOGENOM" id="CLU_013929_4_0_1"/>
    <dbReference type="InParanoid" id="B8ML40"/>
    <dbReference type="OrthoDB" id="4327074at2759"/>
    <dbReference type="PhylomeDB" id="B8ML40"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="98"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="276" mass="31955" checksum="329EA79DE9781852" modified="2009-03-03" version="1">MADYLLSQRGNQQVGENWVYNLVKRRPEIESKFSRKYNYERAKCEDPKIIQEYFDRVREVISDYGILPEDIYNFDETGFAMGLCATAKVITRINSIGWALPSYIIFKAKKYTRLGWFEDLPDDWKINISDNRWTTDKIGLEWLKTHFIPLTDGRTLGKYRMLILDDHGSHLTAEFDRTCTKNNIIPKELHDLRGAHEKEKQKCQRSKQQISHEQGITREEAQALVQGQIEASQAVTTALAEPELPVSHPPIRRQFRCSGCDVAGHKITGSPNRIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8ML55</accession>
    <name>B8ML55_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_049110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485424.1">
        <property type="nucleotide sequence ID" value="XM_002485379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ML55"/>
    <dbReference type="STRING" id="441959.B8ML55"/>
    <dbReference type="GeneID" id="8100627"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_049110"/>
    <dbReference type="eggNOG" id="KOG4388">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003590_1_0_1"/>
    <dbReference type="InParanoid" id="B8ML55"/>
    <dbReference type="OMA" id="NMYDATY"/>
    <dbReference type="OrthoDB" id="5570009at2759"/>
    <dbReference type="PhylomeDB" id="B8ML55"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025:SF3">
        <property type="entry name" value="HORMONE-SENSITIVE LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002875195" evidence="3">
        <location>
            <begin position="17"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="244"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="445"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="378"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="590"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="590"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="610"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="657"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="717"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED15471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="769" mass="86817" checksum="022C06F049A7AA28" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8ML85</accession>
    <name>B8ML85_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_044660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484953.1">
        <property type="nucleotide sequence ID" value="XM_002484908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ML85"/>
    <dbReference type="FunCoup" id="B8ML85">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8ML85"/>
    <dbReference type="GeneID" id="8104142"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_044660"/>
    <dbReference type="eggNOG" id="KOG2961">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056221_3_0_1"/>
    <dbReference type="InParanoid" id="B8ML85"/>
    <dbReference type="OMA" id="MLMANMM"/>
    <dbReference type="OrthoDB" id="198652at2759"/>
    <dbReference type="PhylomeDB" id="B8ML85"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027706">
        <property type="entry name" value="PGP_Pase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09419">
        <property type="entry name" value="PGP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED15000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="231" mass="25562" checksum="42C593E335917362" modified="2009-03-03" version="1">MAPLLNTNLQAFNLTVSTLLKQPSHLLPNLTISTFLDLPEQIGAHLPSRSPNEGEKPNIKALILDKDNTLCPPNTTSIPTPYLQKLEQLRTSPTSPFNLKTNPDGVLIVSNTAGSRPGSRRYENEARTLEEKLRYLRIPVFRVRSSSEGGDGGVITRPDEVVVVGDRLGTDTLMAAQMGSWSVWCKDGVTHSVSNEPGMDYRGFLAKVEIVLERYLRETKGVKVRVPKGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLW6</accession>
    <name>B8MLW6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_097340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485716.1">
        <property type="nucleotide sequence ID" value="XM_002485671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLW6"/>
    <dbReference type="STRING" id="441959.B8MLW6"/>
    <dbReference type="ESTHER" id="talsn-b8mlw6">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="8103432"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_097340"/>
    <dbReference type="eggNOG" id="ENOG502RZIH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046066_1_3_1"/>
    <dbReference type="InParanoid" id="B8MLW6"/>
    <dbReference type="OMA" id="QEVIMLM"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="PhylomeDB" id="B8MLW6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="38"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="237" mass="25917" checksum="D853B68630DCB7F3" modified="2009-03-03" version="1">MSVTLPSVVLVPGAWTAPKAYHKLICALEAKTFKTVCEAVQPLVDAGQEVIMLMHSYGGIAGTSGIRNFTRKDRQARNLPGGVVSLIYAAGFMLSEGQTIRTVVQAVNLPGRSSLVKFSIDNSTWFPIDPIWLLYHDLAPDDQEEQVKLLKWGNAAILTGQTTYAAWKDVPTLYIRSLKDRWLPPEFQDFCLQNAADVGAPVRVAALDSGHSPYINFAAELAQMTFEAAIDAQAHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MM16</accession>
    <name>B8MM16_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_097840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485766.1">
        <property type="nucleotide sequence ID" value="XM_002485721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MM16"/>
    <dbReference type="STRING" id="441959.B8MM16"/>
    <dbReference type="GeneID" id="8108423"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_097840"/>
    <dbReference type="eggNOG" id="ENOG502QSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_0_2_1"/>
    <dbReference type="InParanoid" id="B8MM16"/>
    <dbReference type="OMA" id="QILGWPK"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="PhylomeDB" id="B8MM16"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED13528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="35215" checksum="78C7E8DD9D3E4F1F" modified="2009-03-03" version="1">MRMDDDTMPIIMAPIGMPWVQQLEPFTATNILSRGPNDERAMDHLDLGHHLYSLMLQGELYLVPISKNPQNVLDVGTGTASGQCHDFASLHPSAKVIGTDLSPIQPSLVPPNLQFEIDDCCDEWVYAANSFDFIHVRGLYGCVADWDKFYKESMRHLKPGGYMEQVEISVVPKSEDGSVDGTIFEKWGVVSLQAGDAFGKTLRIVDEAKDRMIAAGFVDVVERRFKLPIGPWPKDRHLKELGLYNRLYWEEGIQGWTMMLLTSILKWKREEVELYLMEVRQGLRNPKYHAYHDCTVVYGRKAPEIPEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MM74</accession>
    <name>B8MM74_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-hydroxyphenylpyruvate dioxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_098430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485824.1">
        <property type="nucleotide sequence ID" value="XM_002485779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MM74"/>
    <dbReference type="STRING" id="441959.B8MM74"/>
    <dbReference type="GeneID" id="8099671"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_098430"/>
    <dbReference type="eggNOG" id="ENOG502QQ4I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035063_0_0_1"/>
    <dbReference type="InParanoid" id="B8MM74"/>
    <dbReference type="OMA" id="NLCFAAH"/>
    <dbReference type="OrthoDB" id="5360893at2759"/>
    <dbReference type="PhylomeDB" id="B8MM74"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF38">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G00240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="1">
        <location>
            <begin position="24"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="321" mass="36132" checksum="8343A491681C0FC7" modified="2009-03-03" version="1">MENPLAIATVALGQHPYHSLPSKIKAAAQHGFSAVEIVYNDLASYADSRLPKVTVQDAAEEIAALCTAYNVAILSLNPFRNFEGHSSPLSKRLEAARHWIEVAQLLKAHTGDENVIIPELQHLADMTAAIAPGLKISYEAVAWGAYVSTWQDSLRVVQLVGRDNFGLCLDSFHVVARLWGDITTESGKQEQPGKNVDDILQQSLDKFVATCPLDKIFYIQLSDGEKYWPPLSPQHRFYDANYPSLLIWSRNTRPFPLETEYGSYMPVAEVARAWLVGKRWKGYVSLEAFDWRMRDEENGPEDNARRGMESWKKLLAELKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMD1</accession>
    <name>B8MMD1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Purine nucleoside permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_099370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485923.1">
        <property type="nucleotide sequence ID" value="XM_002485878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMD1"/>
    <dbReference type="STRING" id="441959.B8MMD1"/>
    <dbReference type="GeneID" id="8104015"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_099370"/>
    <dbReference type="eggNOG" id="ENOG502QQPU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031475_0_1_1"/>
    <dbReference type="InParanoid" id="B8MMD1"/>
    <dbReference type="OMA" id="WAHYLVE"/>
    <dbReference type="OrthoDB" id="2331083at2759"/>
    <dbReference type="PhylomeDB" id="B8MMD1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009486">
        <property type="entry name" value="Pur_nuclsid_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643:SF1">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06516">
        <property type="entry name" value="NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877680" evidence="1">
        <location>
            <begin position="21"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="410" mass="44779" checksum="323CE18256B3ED15" modified="2009-03-03" version="1">MLALKHLLAGLAIVPTLIGAAPVDERCDCEKPAPKVFIISMFAPEAEVWWGIPEFNLLAHNISIPGLSPLFPHVHCTENHEICQLITGESEINAATTISSVAFSDKFDLTSTYFFIGGIAGINPEVATTGSVTFARYAIQVALQYELDAREIPSNWSTGYWAQGSYGPNQYPESIYGTEVFEVNVNLRSKAVAFARKGNLTDSAQAASYRAQYLQGEGVNIYQAGAKPPSVVECDVATSDVYYTGNLLSEAFDNTTRIFTNGTGTYCSTAQEDNATLEVLTRAALHKKVDFARIIVMRTASDFDRPYPGEDAAYHILYANQDGFEIAIQNIYRAGVHVVQGILNEWEETFKCGVKPDNYIGDIFGTLGGNPNFGPGREIALKEGGALLTKRGSSVKKMRSMRKKGVVLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8MME4</accession>
    <name>B8MME4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G-patch domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_099500</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485936.1">
        <property type="nucleotide sequence ID" value="XM_002485891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MME4"/>
    <dbReference type="STRING" id="441959.B8MME4"/>
    <dbReference type="GeneID" id="8105393"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_099500"/>
    <dbReference type="eggNOG" id="KOG0154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012131_1_1_1"/>
    <dbReference type="InParanoid" id="B8MME4"/>
    <dbReference type="OMA" id="MYDDRSP"/>
    <dbReference type="OrthoDB" id="29221at2759"/>
    <dbReference type="PhylomeDB" id="B8MME4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055494">
        <property type="entry name" value="DUF7066"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948:SF3">
        <property type="entry name" value="FI21118P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23217">
        <property type="entry name" value="DUF7066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="123"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="13">
        <location>
            <begin position="222"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="12">
        <location>
            <begin position="621"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="440"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="493"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="568"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="440"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="493"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="568"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED13698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="703" mass="79243" checksum="BED16F594E6CC204" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMN2</accession>
    <name>B8MMN2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Siderophore biosynthesis lipase/esterase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_100310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486024.1">
        <property type="nucleotide sequence ID" value="XM_002485979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMN2"/>
    <dbReference type="STRING" id="441959.B8MMN2"/>
    <dbReference type="ESTHER" id="talsn-b8mmn2">
        <property type="family name" value="Fusarinine_C_esterase_sidJ"/>
    </dbReference>
    <dbReference type="GeneID" id="8097915"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_100310"/>
    <dbReference type="eggNOG" id="KOG4840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049633_3_0_1"/>
    <dbReference type="InParanoid" id="B8MMN2"/>
    <dbReference type="OMA" id="ALQPTEW"/>
    <dbReference type="OrthoDB" id="10034502at2759"/>
    <dbReference type="PhylomeDB" id="B8MMN2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF1">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED13786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="357" mass="40327" checksum="70383E57AEFFB8BA" modified="2009-03-03" version="1">MYSKFWPKGGLPGILHHYTETLVTFEFTSNAVQQPYSILFVGGLGDGLATTSYTSDLVRALQPTKWSLFTLNFTSSYQSWGLGHLDRDTNEIAQCLQYISEYKASKFGHDNSKIVLMGHSTGSQCVLHYLYRPNPHTTTPVFDSDLQHIKRRVLDGAIMQAPVSDREAILWVLTEGIGGKTPSEVREVYEKVEKIAKEADRQNRETNSRFDTLLPISLTSQTGYPVNTPLSARRFLSLVSPESPQSPREDDLFSSDIGEEQLAKTFGMIKQQGLLKNKLLVLYSGKDQSVPDWVDKEKLLSKWRNATDRNGKYEVWDQEYSGIIPGASHALSNDDQAEPRRDLVRRVMGYLQKLENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMN4</accession>
    <name>B8MMN4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_100330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486026.1">
        <property type="nucleotide sequence ID" value="XM_002485981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMN4"/>
    <dbReference type="STRING" id="441959.B8MMN4"/>
    <dbReference type="GeneID" id="8097917"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_100330"/>
    <dbReference type="eggNOG" id="ENOG502SJSN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023254_3_1_1"/>
    <dbReference type="InParanoid" id="B8MMN4"/>
    <dbReference type="OMA" id="HRWFFDI"/>
    <dbReference type="OrthoDB" id="4158087at2759"/>
    <dbReference type="PhylomeDB" id="B8MMN4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF9">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED13788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="477" mass="54986" checksum="C72F2719A57D4B40" modified="2009-03-03" version="1">MDQTFLFVDGFETGKAARQRIRSHVMNGKNAGKKVHRRSRLGLMPSTPYYRRYRTSEQCDSHNVDRESGMSQGLPCPLTNSRILGDPFRTLSYPVEPTSYSLDIFNEFFSHVINKFYPCHLGISPDDAKYWWLQLSLADEAAYHCMIAVTDACIHFFRGGGASTREALYHRSRTLTLVTERLAGDDALSDSTISLVVMMIVQEQIRRGVPEAHIHYEGLRKMIEIRGGISQLEQSPTLLLKICKMDNIYAWQYGRPISFFRDCMPEARARLESEGLPFDLSLAESVAPPHKLNSCLREILLDVINVSVLFNRIPPTTRLNYITFAELVHSICYRLIKFQPLHEPSSLSDLEDVYHMALTVFMMTLFMKFDDQRLLRCEAVFERLRTILRRNLAELDTDLVLWMLFIGGIWIRNGPDDSWLYTKIRKLTRSMGLDSWEEIYPVISVFPWIKSLHNGPGVALWDSVYELSRVGDRKLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMV0</accession>
    <name>B8MMV0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NIPSNAP family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_100960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NipSnap family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486093.1">
        <property type="nucleotide sequence ID" value="XM_002486048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMV0"/>
    <dbReference type="STRING" id="441959.B8MMV0"/>
    <dbReference type="GeneID" id="8101784"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_100960"/>
    <dbReference type="eggNOG" id="KOG2883">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053393_0_0_1"/>
    <dbReference type="InParanoid" id="B8MMV0"/>
    <dbReference type="OMA" id="REKSWSV"/>
    <dbReference type="OrthoDB" id="10262843at2759"/>
    <dbReference type="PhylomeDB" id="B8MMV0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000004">
        <property type="entry name" value="NIPSNAP family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000037">
        <property type="entry name" value="NIPSNAP family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051557">
        <property type="entry name" value="NipSnap_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017">
        <property type="entry name" value="NIPSNAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017:SF17">
        <property type="entry name" value="PROTEIN NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="3">
        <location>
            <begin position="133"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="NIPSNAP" evidence="3">
        <location>
            <begin position="239"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED13855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="338" mass="39360" checksum="A6CF69DB56AFF203" modified="2009-03-03" version="1">MQPSKVLRASPAFSALRSFSTSSIHNRAPSIRDITPTNAAEFDARQKEFRESLEQARKKRLEQESQSVANTLRDRAREQEQLDSAAENGTKRGPLSSLIYGTREGQHFDKSIERSFSQVIARGKYVHSIVFHDVKPDKVDEYVDLVGKWYPRMASLEENKVNLVGSWRTQVGDNDTFVHIWEYQRYTGYHESLHTISQHLDFREFDKQLKSLIKSKETSLMQEFSFWPTTPPRRLGGLFELRSYTLHPGNLLEWETHWRQGLKARREVMEGVGAWFVQIGDLNTVHHLWQFANLEERKIRREQSWGIEGWADTVHRTVPLIQSMKSRILIPMPWSPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMX1</accession>
    <name>B8MMX1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_101600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486158.1">
        <property type="nucleotide sequence ID" value="XM_002486113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMX1"/>
    <dbReference type="STRING" id="441959.B8MMX1"/>
    <dbReference type="GeneID" id="8101848"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_101600"/>
    <dbReference type="eggNOG" id="ENOG502S0NN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034763_1_0_1"/>
    <dbReference type="InParanoid" id="B8MMX1"/>
    <dbReference type="OMA" id="ENDFAFC"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="PhylomeDB" id="B8MMX1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877597" description="AB hydrolase-1 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="33436" checksum="A294201EC1B757C2" modified="2009-03-03" version="1">MILKLTLLISMLPTVFAGKPCCFDFGLPFHVSLPVPQLNVTEFGSSYDSTVFLTASVTRNANLSLLALGQTEINRDFDIHFRYCEPENVDHKNGVLQILSQGVGFDKSYWSFGSEEYNYIASATKAGYATLSDDRLGVGYSEKADPSSEIQVILVRKGQLLDRIPVPKKLVHIGHSFGSLITNGLAATQPSLSAGIVLIGFTHNTSWVTLFELFLGFEVARPSNPARFHGYNSGYLTWGNEYDNRCAFFTLPFFDPAILLHAEALKAPFAISELLSFTSVPLAAGNFTGPVHVRKGMDECLYCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNS5</accession>
    <name>B8MNS5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SQS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_103840</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SQS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486402.1">
        <property type="nucleotide sequence ID" value="XM_002486357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNS5"/>
    <dbReference type="STRING" id="441959.B8MNS5"/>
    <dbReference type="GeneID" id="8103087"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_103840"/>
    <dbReference type="eggNOG" id="KOG0154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007254_1_1_1"/>
    <dbReference type="InParanoid" id="B8MNS5"/>
    <dbReference type="OMA" id="GHRTRDD"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="PhylomeDB" id="B8MNS5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02646">
        <property type="entry name" value="R3H_G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034082">
        <property type="entry name" value="R3H_G-patch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051189">
        <property type="entry name" value="Splicing_assoc_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14195">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="11">
        <location>
            <begin position="350"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="10">
        <location>
            <begin position="482"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="163"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED14164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="525" mass="59127" checksum="563FE11FCE702CBC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNY1</accession>
    <name>B8MNY1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Non-structural maintenance of chromosomes element 1 homolog</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSTA_104360</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NSE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486458.1">
        <property type="nucleotide sequence ID" value="XM_002486413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNY1"/>
    <dbReference type="STRING" id="441959.B8MNY1"/>
    <dbReference type="GeneID" id="8103207"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_104360"/>
    <dbReference type="eggNOG" id="KOG2852">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4718">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_393267_0_0_1"/>
    <dbReference type="InParanoid" id="B8MNY1"/>
    <dbReference type="OMA" id="HEIHIIE"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="PhylomeDB" id="B8MNY1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16493">
        <property type="entry name" value="RING-CH-C4HC3_NSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011513">
        <property type="entry name" value="Nse1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014857">
        <property type="entry name" value="Nse1_RING_C4HC3-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973">
        <property type="entry name" value="NON-SMC ELEMENT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07574">
        <property type="entry name" value="SMC_Nse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08746">
        <property type="entry name" value="zf-RING-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="647"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="710"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="718"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="734"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EED14220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="744" mass="81516" checksum="8B20341773CE6577" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPC0</accession>
    <name>B8MPC0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_105700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486597.1">
        <property type="nucleotide sequence ID" value="XM_002486552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPC0"/>
    <dbReference type="STRING" id="441959.B8MPC0"/>
    <dbReference type="GeneID" id="8100429"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_105700"/>
    <dbReference type="eggNOG" id="KOG2741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_5_2_1"/>
    <dbReference type="InParanoid" id="B8MPC0"/>
    <dbReference type="OMA" id="EWWTTYR"/>
    <dbReference type="OrthoDB" id="6417021at2759"/>
    <dbReference type="PhylomeDB" id="B8MPC0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="25"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="172"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED14359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="438" mass="49945" checksum="8F2B11A4A3308A26" modified="2009-03-03" version="1">MSSFFRRLYLGSISPPLVVKEHDALRIGLLGASNIAPEAVILPARSHPEVIIYCVAARDRNRANIYAKKHNIPVVHDTYDDVINDPSISCVYLALPNSHHFEWALRALKAGKHVLLEKPSTSNAIEAKKLFDHPLVTACDAPVLLEAFHYRFHPAWQTFLDLIHNDPSAGPIKNVYSQSFMPKGNFPDNDIRFKYSLAGGCLMDFAAYNISHVRQMLDDPHPRVQSVVFRTHEHSSTTSPVEGENPEQVDEAVSASYISQTGAIGHVVADMNSRGGWPLLPRSWTQNWPSIGWPKCTAELEEKLIDDHTTHGEKHLVQRVVTLYNHIFPHVYHCITIEDKHIIRLGSEDLRSWVERKNVKAYTWPGDSEDCHGMEWWTTYRYQLEEFVNRIKARHGNGLWISREDSISQMEVIDETYRKGDLKLRPTSTFDIDDGLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQA6</accession>
    <name>B8MQA6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sugar transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_057440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487364.1">
        <property type="nucleotide sequence ID" value="XM_002487319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQA6"/>
    <dbReference type="GeneID" id="8108880"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_057440"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1714535_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQA6"/>
    <dbReference type="OMA" id="VIQCATH"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="PhylomeDB" id="B8MQA6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF11">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER (HXT8), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="12"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED13253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="153" mass="16104" checksum="FC4672BF1DAA433C" modified="2009-03-03" version="1">MAISPSFFRILVVGFVALGSTTYGYSSSSIFTTLGKPSFLSYFVLDMRLGAAQLEGAINELFQAGGLFRSLSCIGSADRLGRKMSILIACSVTVVGGALQAGSVHIAMYLVFRFITGLGVVPLYQSEVSPPKIHGFLVGIHGVILCLGYALAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQV9</accession>
    <name>B8MQV9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Wd40 protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_053120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486905.1">
        <property type="nucleotide sequence ID" value="XM_002486860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQV9"/>
    <dbReference type="STRING" id="441959.B8MQV9"/>
    <dbReference type="GeneID" id="8098261"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_053120"/>
    <dbReference type="eggNOG" id="KOG0271">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_6_0_1"/>
    <dbReference type="InParanoid" id="B8MQV9"/>
    <dbReference type="OMA" id="DCIPQAL"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="PhylomeDB" id="B8MQV9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="192"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="744"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED12794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="810" mass="91863" checksum="DD4C85C9463B8D3B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRW3</accession>
    <name>B8MRW3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF821 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_057860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487408.1">
        <property type="nucleotide sequence ID" value="XM_002487363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRW3"/>
    <dbReference type="GeneID" id="8108922"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_057860"/>
    <dbReference type="eggNOG" id="KOG2458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028539_2_1_1"/>
    <dbReference type="InParanoid" id="B8MRW3"/>
    <dbReference type="OMA" id="ESCYWRY"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="PhylomeDB" id="B8MRW3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF112">
        <property type="entry name" value="DUF821 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G14740)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="206"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED13297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="482" mass="55380" checksum="2EBE42DAF9DFC4D5" modified="2009-03-03" version="1">MWGPGKVNTRQKMAKQQQSKPTWATTSPRVLGLLRPRILIALGCALTLLLSACLLVLRFQNQSYALQLQLFRPSRYFEKECYAAGESATDRLQHGSTEMSNGEWEFVASRDANNYALNSEQCLAAFPKLFTEIDKSVEQRKETNNPITFKEIDSRKTLGQGMARAMIYKGELFIIEYGDMMYTASRAKSTLHSLHRALVATPDRESLPSIEFHFSADDFVWDDLKLAGGPVWAYSKRDTSDIDEDAVDDSNIWLMPDFGYWAWPEVDIAPYRETRRRIAAVDAEFKTFQSKKKQLLWRGSLNTAAELRNGLIDATKNKYWASVRVVDWGNKKSVEENLLPIEDHCRYMFLAHTEGRSFSGRGKYLLNCHSVFITHPLIWREAHHAAFVSSGPEANYIEVARDFSNLESKVEYLLDNPQIAERIANNSVTTFRDRYLTPAAEACYWRYLIQKYGEVSDFEPKLYDDRTGKMRGQPYEQWVLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MS89</accession>
    <name>B8MS89_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arsenite methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_002860</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>arsenic triglutathione + 2 [thioredoxin]-dithiol + 2 S-adenosyl-L-methionine + H2O = dimethylarsinous acid + 2 [thioredoxin]-disulfide + 3 glutathione + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:69464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:23808"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:183640"/>
            <dbReference type="EC" id="2.1.1.137"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:69432"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27130"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:183640"/>
            <dbReference type="EC" id="2.1.1.137"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>arsenic triglutathione + [thioredoxin]-dithiol + S-adenosyl-L-methionine + 2 H2O = methylarsonous acid + [thioredoxin]-disulfide + 3 glutathione + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69460"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17826"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:183640"/>
            <dbReference type="EC" id="2.1.1.137"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.137" evidence="4"/>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487876.1">
        <property type="nucleotide sequence ID" value="XM_002487831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MS89"/>
    <dbReference type="STRING" id="441959.B8MS89"/>
    <dbReference type="GeneID" id="8102897"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_002860"/>
    <dbReference type="eggNOG" id="ENOG502QQD6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052868_3_1_1"/>
    <dbReference type="InParanoid" id="B8MS89"/>
    <dbReference type="OMA" id="CVINHAK"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="PhylomeDB" id="B8MS89"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030791">
        <property type="term" value="F:arsenite methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026669">
        <property type="entry name" value="Arsenite_MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008823">
        <property type="entry name" value="PRK11873.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675">
        <property type="entry name" value="ARSENITE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675:SF8">
        <property type="entry name" value="ARSENITE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="9">
        <location>
            <begin position="65"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED12222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="275" mass="29145" checksum="92550BB9A81B66B3" modified="2009-03-03" version="1">MADIYQLVQACYGNIAKKIVTNQEQDGEKKIAMAFGYSGDDLLSLPEKTNLGLSCGNPVAYANVKEGETVVDLGSGGGIDVFLAARKVGPAGKAIGIDMTKNMIDLAIENAKAAGLSNATFIEASITSIPLPSSSVDCIISNCVINLVPAKDKGSVFHEIARLLKPGGRLAISDILARKPLPKNIVEDMALYMGCIAGASQVAEYEEYLRQAGFQDILLVDTKSNLNLYKESSYLQQSTCCGPSSGSKEQKADSANIDYNECAGSFQIYAVKPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSA0</accession>
    <name>B8MSA0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ilp is an apoptosis inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_002960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487887.1">
        <property type="nucleotide sequence ID" value="XM_002487842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSA0"/>
    <dbReference type="GeneID" id="8097993"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_002960"/>
    <dbReference type="eggNOG" id="ENOG502S2F8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079969_2_0_1"/>
    <dbReference type="InParanoid" id="B8MSA0"/>
    <dbReference type="OMA" id="FPHYKNC"/>
    <dbReference type="OrthoDB" id="5335812at2759"/>
    <dbReference type="PhylomeDB" id="B8MSA0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053267">
        <property type="entry name" value="Verrucosidin_biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42087:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42087">
        <property type="entry name" value="ILP IS AN APOPTOSIS INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="29830" checksum="B8C074B11ABE5236" modified="2009-03-03" version="1">MSTSYNYDTSTQLGLRLRLWRGLRSIVTRRRVFVSEPNRQLSHGRKENAIQQSEMQPGAGTTTSTKTTTTTTIQMPSTTLFTDDGKVNPSEWFPVYQGCIEYFVNVAQHRPLAQSIAAHINILLPYQRAESPSNSQNQSGSTDQQQSESQLFSLIPYIRRLVVTATDTPVVMQELFGDGWLRGVGAILSQERINYLFSAKSGGWLKTKAQYDILPYETVPFLRPLRDPQEEELRAAEARWSEWLAMEDWMVGPRSPFEDSSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8MT22</accession>
    <name>B8MT22_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_001730</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487756.1">
        <property type="nucleotide sequence ID" value="XM_002487711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MT22"/>
    <dbReference type="STRING" id="441959.B8MT22"/>
    <dbReference type="GeneID" id="8098667"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_001730"/>
    <dbReference type="eggNOG" id="KOG1121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_554519_0_0_1"/>
    <dbReference type="InParanoid" id="B8MT22"/>
    <dbReference type="OMA" id="LWTHEST"/>
    <dbReference type="OrthoDB" id="4837779at2759"/>
    <dbReference type="PhylomeDB" id="B8MT22"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025525">
        <property type="entry name" value="hAT-like_transposase_RNase-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14372">
        <property type="entry name" value="hAT-like_RNase-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="hAT-like transposase RNase-H fold" evidence="8">
        <location>
            <begin position="324"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="473"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED12102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="511" mass="58844" checksum="9929D4BCC05C93AA" modified="2009-03-03" version="1">MSTLSNKPVPAPHQNISSDKLSLALRLHGVLKEAITEMIDFFCALLRWVIETQQPFTVVEHPTWKELLKSLNANYPIKTADTLRNQFKEINGLHSGENLSTIVKSVLEAFQIEYKLLTITRDNARNNLTLYDYLHADLLKDFNKEDSLFRMKPLMRFQGRNSFIGCLAHILNLICKDILVSLKTGTVRDAHVILNEMPSQKDHSPETLISMKGAIVKIRLLALWISNSPQRRQAWKDISPYKQINYDINTHWNSTYNIVSKALQLRKEVTQFIREHPDIQEMQPTDSDWSTLRQIQKVLKPFWDHTNSVSKHCLSITKSLPIYWSLNDILDDIKNNKDDFQEITKEVQNAVEGGIRKMDKFTKKMDSNIIYYMAAILDPRVKTSFIQAQMSKSDADVIISNIHKYLKKQYPASPTSSSSAERPPGMPGTLWKKLKKIQPLQSADIISDIDWYLDSSPEMWSHGIIEDGDPDWILKWWKANAFNYPLMSKAIQDYLPILSAEVGVKRLFSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTW7</accession>
    <name>B8MTW7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras family GTPase (Rab4b), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_006110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488235.1">
        <property type="nucleotide sequence ID" value="XM_002488190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTW7"/>
    <dbReference type="STRING" id="441959.B8MTW7"/>
    <dbReference type="GeneID" id="8105296"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_006110"/>
    <dbReference type="eggNOG" id="KOG0086">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_6_0_1"/>
    <dbReference type="InParanoid" id="B8MTW7"/>
    <dbReference type="OMA" id="HRFVKSE"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="PhylomeDB" id="B8MTW7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED12581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="350" mass="37776" checksum="FBEA4BABE079EC93" modified="2009-03-03" version="1">MPRHRKQSNASSTSSIPDRNQELESMYDYLAKVILIGPSGTGKSCLLHRFVKDEWRVLSSQTIGVEFSSKIVKIGTGSRRKRIKLQLWDTAGTERFRSVSRSYYRGAAGAVLVYDVSSYASFAALPTFLMDARALASPNLTTILAGNKTDLLVDGDETEMEETEDEASTSIANSVSSSRNTSMYMFDAASSKTGAGSLRSVTSTNFSTAGTRLTATKASHGRQVSDLEAIEWATRSNIPVAVEVSAFSGQNVEELFTRLARIILTKIELGEIDPDDPQSGIQYGDSGAWGMAASDAASVRSGLTVDDSASQLHGRRKRNAKRSNNSSWMGSAGEWGDVFRITGSTRGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUS5</accession>
    <name>B8MUS5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_109930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488569.1">
        <property type="nucleotide sequence ID" value="XM_002488524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUS5"/>
    <dbReference type="STRING" id="441959.B8MUS5"/>
    <dbReference type="GeneID" id="8107225"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109930"/>
    <dbReference type="HOGENOM" id="CLU_128542_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUS5"/>
    <dbReference type="OMA" id="AESEWEP"/>
    <dbReference type="OrthoDB" id="4354814at2759"/>
    <dbReference type="PhylomeDB" id="B8MUS5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24403" checksum="BDAC91F056E09B42" modified="2009-03-03" version="1">MPPHSSHLLKPLDQHYGQIVEQRMRLGFNHIDKIDFLTAFPKARMMAYKAQTVRNSFTATGLVPFNPDRVYQQLTVRLKTPTPPQSRSSDTQSSCLQTPQTPRQFKRQMTKTKKRISRHTRSSSEAIGEVFTRASKAYEMSINKLTIAQKELHDLWAAHEKEKQKRQKSKKQISHDQGITREEAQALVQGQIEASQAVTTAPAEHELPVSHPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUY8</accession>
    <name>B8MUY8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_110090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488585.1">
        <property type="nucleotide sequence ID" value="XM_002488540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUY8"/>
    <dbReference type="STRING" id="441959.B8MUY8"/>
    <dbReference type="GeneID" id="8107241"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_110090"/>
    <dbReference type="eggNOG" id="ENOG502SZB5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1901342_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUY8"/>
    <dbReference type="OrthoDB" id="4368687at2759"/>
    <dbReference type="PhylomeDB" id="B8MUY8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="15458" checksum="BCC7B7F60BFAD869" modified="2009-03-03" version="1" fragment="single">MESRYASISFDDFQIEISSLEHTGLAQGSPLSPILFRFFNSDLVDQPVDYYGGASAFIDNYFRWRAGPSAEDNVRKIQEEDILRIKVNIALGGLRHLRLEQMRQLYQVCVTPIVDYASTVWHNPLKDKVYLRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8MV94</accession>
    <name>B8MV94_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_008460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962662">
        <property type="protein sequence ID" value="EED11550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488731.1">
        <property type="nucleotide sequence ID" value="XM_002488686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MV94"/>
    <dbReference type="GeneID" id="8108580"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_008460"/>
    <dbReference type="HOGENOM" id="CLU_2051234_0_0_1"/>
    <dbReference type="InParanoid" id="B8MV94"/>
    <dbReference type="OrthoDB" id="4207519at2759"/>
    <dbReference type="PhylomeDB" id="B8MV94"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="14461" checksum="047F84B3460177A3" modified="2009-03-03" version="1">MRKFLQNYHNRGKDSITISDLKNGRISNICEAARIYAIPRIALRDRLKRVQYQHLDKRGLPPRYSLEQERGNQQVGEKWVYNLIQRRPEIKSRFLRKYKYERAIITYIDSSVIWKILKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8MVL2</accession>
    <name>B8MVL2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_080500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962664">
        <property type="protein sequence ID" value="EED11439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488849.1">
        <property type="nucleotide sequence ID" value="XM_002488804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MVL2"/>
    <dbReference type="STRING" id="441959.B8MVL2"/>
    <dbReference type="GeneID" id="8108973"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_080500"/>
    <dbReference type="eggNOG" id="ENOG502SKGQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027514_0_0_1"/>
    <dbReference type="InParanoid" id="B8MVL2"/>
    <dbReference type="OMA" id="YICDYRK"/>
    <dbReference type="OrthoDB" id="4851849at2759"/>
    <dbReference type="PhylomeDB" id="B8MVL2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="435" mass="49517" checksum="B4745149CF4A7DCC" modified="2009-03-03" version="1">MPKRKKKSSRSIIQARAKKEIGNSGLAAIVPCSPSRAIRPSTPNSHFTLTVEKVLNRYPRLERRFYESLVLLSVLDPVRGCRFTNSIYTTDDTLDQLRRSFVDAIAMICDSHKGGDTVMAVALQSTPFRTVIWLAANKNPKTGTVQYLQRIVDTLRKATPDTRVRVADEISDCVVEFCRSSSIKDIINVCMKCRIYFPMLSRFSRRETDHHQPVTRTKHFIGRLATYSRTVNTLLDVAFDIPQLLENCELRICESSRHLPSPLNPDASTLDGIVRRMFPEFTANEVRSGLDRLNVFGNLHERTRRACSFKSRVHAELLVLEKFRSNGWEFVAGDKYIGCSKPSCFCCYHYINSLPERYSVSGCHNKIYTHWRAPDLTGVQDLEAVKVREDALNAVVAKLRAEVCRCIDERPVKIRPHYDSVTGSTSVIRLEEAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTS4</accession>
    <name>B8LTS4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_070730</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341053.1">
        <property type="nucleotide sequence ID" value="XM_002341012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTS4"/>
    <dbReference type="FunCoup" id="B8LTS4">
        <property type="interactions" value="454"/>
    </dbReference>
    <dbReference type="GeneID" id="8101060"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_070730"/>
    <dbReference type="eggNOG" id="KOG0764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_6_1_1"/>
    <dbReference type="InParanoid" id="B8LTS4"/>
    <dbReference type="OMA" id="AFYNGMG"/>
    <dbReference type="OrthoDB" id="10266426at2759"/>
    <dbReference type="PhylomeDB" id="B8LTS4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF1">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06780)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="53"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="158"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="266"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="297"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED23666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="411" mass="45981" checksum="E76BA6DC64956076" modified="2009-03-03" version="1">MASDDSARRPVVRPEQHQDLYHEHHTSTHLPKSPTTPYSKMLARLEIASTHIPSFYITPFCGAMAGVASGIVTCPLDVIKTKLQAQGGFLRRRSAHRTETAEIYRGMIGTGKTIWKNQGIRGLYQGLGPMLLGYLPTWAVYLTVYDKSRSFWETKTDNWWLSRTYASVTAGACSTVVTNPIWVIKTRLMSQSGRVSGDGFIPWHYRNSWDAARKMYMTEGIRAFYSGLTPALLGLSHVAIQFPLYEYFKMAFTGYGIGEHPDEGDSHWVGISLATFLSKVCASTATYPHEVLRTRLQTQQRHPPASSPEEIAFRGGLDHPVNRGRPPGAASSDGMPNRPRYAGAWRTCQTILREEGWRAFYSGIGVNLIRAVPAAMTTMLTYEYLRKTINTLQHEGQKRLDDVDVSGDTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTT2</accession>
    <name>B8LTT2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquinone biosynthesis protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_070800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341061.1">
        <property type="nucleotide sequence ID" value="XM_002341020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTT2"/>
    <dbReference type="FunCoup" id="B8LTT2">
        <property type="interactions" value="476"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LTT2"/>
    <dbReference type="GeneID" id="8109483"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_070800"/>
    <dbReference type="eggNOG" id="KOG1235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_2_5_1"/>
    <dbReference type="InParanoid" id="B8LTT2"/>
    <dbReference type="OMA" id="RCNPEDI"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="PhylomeDB" id="B8LTT2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="190"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED23674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="600" mass="67898" checksum="EAC0E8C64290EC8B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTV8</accession>
    <name>B8LTV8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc binding dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_071840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341175.1">
        <property type="nucleotide sequence ID" value="XM_002341134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTV8"/>
    <dbReference type="STRING" id="441959.B8LTV8"/>
    <dbReference type="GeneID" id="8107645"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_071840"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_0_1"/>
    <dbReference type="InParanoid" id="B8LTV8"/>
    <dbReference type="OMA" id="AFATEYY"/>
    <dbReference type="OrthoDB" id="3233595at2759"/>
    <dbReference type="PhylomeDB" id="B8LTV8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF5">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="12"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED23788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="362" mass="39600" checksum="111A0A4AE2DD9F86" modified="2009-03-03" version="1">MTTNMIEYTISGKPGPIKATRSIAPIPKPGANEVLIKVIATDSNPKDWKAFRNHEEGRGINQGDDISGIVESVGSSVWEFAPGDRVAAFHRMFQPHGSYAQYAIAPASTTFRLPANTSFEAGATLPLASMTAALALYQNLSLPLPWNPAKTETPILIYGGASAVGAYALKFAKFSGLSPIITVAGNGIDFVKSLNAADHIIDYRNGNVVEAIQAALEGRKLHHAFDAVSYNRSYENIVAVLQASRGGQIDMVDPPSDDSAIPNRDSWNWPEGIKFTRTFVSSAYGTPHKYRDETQAAEDHEFAYVFYRYISRLLAEEKLKPHPFEVLPKGLESVAEGIQLLYDRKVSAQKLVYRIADTPNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8LU30</accession>
    <name>B8LU30_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_060000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002339889.1">
        <property type="nucleotide sequence ID" value="XM_002339848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LU30"/>
    <dbReference type="STRING" id="441959.B8LU30"/>
    <dbReference type="GeneID" id="8108645"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_060000"/>
    <dbReference type="eggNOG" id="ENOG502T13H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1050437_0_0_1"/>
    <dbReference type="InParanoid" id="B8LU30"/>
    <dbReference type="OMA" id="LENCAGY"/>
    <dbReference type="OrthoDB" id="4225668at2759"/>
    <dbReference type="PhylomeDB" id="B8LU30"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED22502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="259" mass="29450" checksum="EF86FB3D95DEEAC1" modified="2009-03-03" version="1">MSRKEASRKTILPKTLKDLRSVKDTLVTPLDTARTTDQPPDDLLWKEEDPSTKYILSHKFNQAGAGWIGFENCQGLRTVFVKIVKATSHQKLQFHKTDQANLINLQEVFHSKNVTYLIYDFDRCDLPLSMVHASPNVQFTEADIAIVCRQVLTGLQYIHEKLKISHGSIKLSDLVLSQSGQVKIANIGESMLQGKTLEHRRGDLQGLALVLIHLKNPHTILEDGRMHVNNPRDVSREACEFIEMTKSATYRELFQVSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8LU88</accession>
    <name>B8LU88_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multicopper oxidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_060530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002339948.1">
        <property type="nucleotide sequence ID" value="XM_002339907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LU88"/>
    <dbReference type="STRING" id="441959.B8LU88"/>
    <dbReference type="GeneID" id="8108583"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_060530"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_7_3_1"/>
    <dbReference type="InParanoid" id="B8LU88"/>
    <dbReference type="OMA" id="PGPSHNC"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="PhylomeDB" id="B8LU88"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="56"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="269"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED22561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="455" mass="50617" checksum="2DC4B0393D0943A9" modified="2009-03-03" version="1">MSQEHIGTIVSIVPSPIWIIVNMIICHSPSQYVDGIRGPILVNDPLSPYAGQIDGELVVTLSDWYHEQGASLQVYYLSLPGNPNALEPIPMSALMNDQLWPTFSVLPNKTYFVRVLNIAGYAQFYFHIDGHNMTIIQADGVYTDPQQVQDLYLATGQRYGVLLHTLPTANQNYAILGAMDIAGFPRSAPPPANPNVTGVLVYDPFLSIPSTPVVQQFSTFDDFCLNPFDKIPLLYPPNKEIVLNLSTFSQTVPLNEQNRGGFNNITYITQRVPSLYTALSGGLYALNPIVYGNHSNPFVLSLGDFVETTIYNYDTGLHPIHTHGHTVQLVARTGSECNYRSIPMRRDTWMEPRWNSSDPNHPSTVVRFIADNPGIWFFHCHMEWHLVAGMDIILVEDPLQIQTGQPDIPLSMKLICLEQGIPLMGNAAGNWINFLDLTGEVNVAPMECGSDYPPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUG7</accession>
    <name>B8LUG7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MFS transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_071370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341127.1">
        <property type="nucleotide sequence ID" value="XM_002341086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUG7"/>
    <dbReference type="STRING" id="441959.B8LUG7"/>
    <dbReference type="GeneID" id="8107659"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_071370"/>
    <dbReference type="eggNOG" id="ENOG502QWBF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013756_2_3_1"/>
    <dbReference type="InParanoid" id="B8LUG7"/>
    <dbReference type="OMA" id="RFISIRW"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="PhylomeDB" id="B8LUG7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED23740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="56047" checksum="1D25BBC0497522A0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8LV02</accession>
    <name>B8LV02_TALSN</name>
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        <recommendedName>
            <fullName evidence="2">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_061140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340010.1">
        <property type="nucleotide sequence ID" value="XM_002339969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LV02"/>
    <dbReference type="STRING" id="441959.B8LV02"/>
    <dbReference type="GeneID" id="8107320"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_061140"/>
    <dbReference type="HOGENOM" id="CLU_508225_0_0_1"/>
    <dbReference type="InParanoid" id="B8LV02"/>
    <dbReference type="OrthoDB" id="4368270at2759"/>
    <dbReference type="PhylomeDB" id="B8LV02"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718">
        <property type="entry name" value="OS01G0519700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718:SF3">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="2">
        <location>
            <begin position="140"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED22623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="536" mass="60940" checksum="CE967A60D2A9F417" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8LV99</accession>
    <name>B8LV99_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">TSTA_066020</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340536.1">
        <property type="nucleotide sequence ID" value="XM_002340495.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B8LV99">
        <property type="interactions" value="610"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LV99"/>
    <dbReference type="GeneID" id="8106603"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_066020"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001650_18_4_1"/>
    <dbReference type="InParanoid" id="B8LV99"/>
    <dbReference type="OrthoDB" id="4356562at2759"/>
    <dbReference type="PhylomeDB" id="B8LV99"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="20" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="25">
        <location>
            <begin position="588"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="222"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="908"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="998"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="938"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1000"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1023"/>
            <end position="1048"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EED23149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1630" mass="187449" checksum="0118BF5C86B1A613" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVA2</accession>
    <name>B8LVA2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Salicylate hydroxylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_066050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340539.1">
        <property type="nucleotide sequence ID" value="XM_002340498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVA2"/>
    <dbReference type="STRING" id="441959.B8LVA2"/>
    <dbReference type="GeneID" id="8104710"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_066050"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_4_0_1"/>
    <dbReference type="InParanoid" id="B8LVA2"/>
    <dbReference type="OMA" id="AVHGYYF"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="PhylomeDB" id="B8LVA2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972:SF1">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972">
        <property type="entry name" value="MONOOXYGENASE ASQM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="7"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED23152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="408" mass="46374" checksum="F6D327CCAFCE492D" modified="2009-03-03" version="1">MERKPNIAIIGAGPSGLTLARILHQHGIPTTIFERDESQNARKTEGGSLDLSLDGGQKAIRMAGIWEEYNKLARYEAEALKLIDRHGKVYLDSTGFDTGRPEIDRTELRRILLESLPKEYIRWNHHLKRVDPDGTLHLAHTIESGFDLIVGAEGTWSKVRNVLTPIQPFYSGVTVYETLYENVDEAHPEFAALVGEGSLLVIGNETGIHQMTQRQGDRSIRTYAYIRQPETWGSDVDWHDPKAAREALLPWFNDWDPQFTQFVTATENPVLARKLYILPVGLRWPHKDNFTIIGDAAHVMTPFEGEGVNAAMRDSLELAQAIIANPTDIPQAVKNYEEIMWKIGEQKQKQTWDNMMRTLDYNGIEYLHDRLQHLMGMIKEGKMAKNGTPPNPKYSHILNTEAQILEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVN0</accession>
    <name>B8LVN0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_075320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341547.1">
        <property type="nucleotide sequence ID" value="XM_002341506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVN0"/>
    <dbReference type="GeneID" id="8100189"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_075320"/>
    <dbReference type="eggNOG" id="KOG0013">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054816_2_0_1"/>
    <dbReference type="InParanoid" id="B8LVN0"/>
    <dbReference type="OMA" id="GCMGRYL"/>
    <dbReference type="OrthoDB" id="1640476at2759"/>
    <dbReference type="PhylomeDB" id="B8LVN0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.225.20">
        <property type="entry name" value="Ub domain-containing protein, DC-UbP/UBTD2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032752">
        <property type="entry name" value="DC-UbP/UBTD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038169">
        <property type="entry name" value="DC-UbP/UBTD2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039869">
        <property type="entry name" value="UBTD1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13609">
        <property type="entry name" value="UBIQUITIN DOMAIN CONTAINING 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16455">
        <property type="entry name" value="UBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="222"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED24160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="301" mass="33882" checksum="AF611D9BEAC6F1E8" modified="2009-03-03" version="1">MGCCLSRSSNEEQPFHASTATQEPQEDALSTHHSEQHSRQQASNSSTRRRSRPRCQGVALPLDQHYNQPIRPHIWRSKRRLWTRTQIDREREEFFDTRVTGREEVWAALRAALSLLREGDIETAQGIIDAAGVTVPTGDFCDGCYDENGVLYRLPQCIVSDPDNIADDSGAAAGETDGVDDDMEDGISDRKIVSEESDEELISEDAERRREEKGKMSERDMIRVQARLSDRGGPDVMISIGKTQNVSLLARKIHSETKMSNTQRVRIVYLGRVLRENEPLVDQGWKQGHVINAMVVARPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWE8</accession>
    <name>B8LWE8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 26, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_076290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS26 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341646.1">
        <property type="nucleotide sequence ID" value="XM_002341605.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341647.1">
        <property type="nucleotide sequence ID" value="XM_002341606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341648.1">
        <property type="nucleotide sequence ID" value="XM_002341607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWE8"/>
    <dbReference type="FunCoup" id="B8LWE8">
        <property type="interactions" value="846"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LWE8"/>
    <dbReference type="GeneID" id="8102391"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_076290"/>
    <dbReference type="eggNOG" id="KOG3063">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031077_1_1_1"/>
    <dbReference type="InParanoid" id="B8LWE8"/>
    <dbReference type="OMA" id="FKWKFSS"/>
    <dbReference type="OrthoDB" id="3821113at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170071">
        <property type="term" value="C:CROP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030906">
        <property type="term" value="C:retromer, cargo-selective complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140318">
        <property type="term" value="F:protein transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000004">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000010">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED24259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="358" mass="41251" checksum="0CEBB87E141FB733" modified="2009-03-03" version="1">MAPFFFSTPVDIDIVLEDSDERQTVDVKLDKGRREKAPLYMDGESVKGAVTVRPKDGKRLEHTGIKVQFIGSIEMFFDRGNHYEFLSLVQELAAPGELQHPQTFPFNFKNVEKQYESYNGINVKLRYFVRVTVSRRMADVIREKDLWVYSYRMPPETNSPIKMDVGIEDCLHIEFEYSKSQYHLKDVIVGRIYFLLVRLKIKHMELSIIRRETTGAAPNQYNESETLVRFEIMDGSPSRGETIPIRLFLGGFDLSPTFRDVNKKYSTRYYLSLVLIDEDARRYFKQSEIVLYRQAPEIAPTPEVAQQQLIQQQQIQKQQQVLVGPSKNPQYHQPPVQSQAEASSSSNPASAPEAQAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWL5</accession>
    <name>B8LWL5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_077710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341799.1">
        <property type="nucleotide sequence ID" value="XM_002341758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWL5"/>
    <dbReference type="STRING" id="441959.B8LWL5"/>
    <dbReference type="GeneID" id="8106044"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_077710"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_23_1"/>
    <dbReference type="InParanoid" id="B8LWL5"/>
    <dbReference type="OMA" id="IGHHRIN"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="PhylomeDB" id="B8LWL5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="6"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="512"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="545"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="769"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="816"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED24412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="901" mass="101177" checksum="FEAE8C01761D749D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWV1</accession>
    <name>B8LWV1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_079390</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341971.1">
        <property type="nucleotide sequence ID" value="XM_002341930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWV1"/>
    <dbReference type="STRING" id="441959.B8LWV1"/>
    <dbReference type="GeneID" id="8107632"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_079390"/>
    <dbReference type="eggNOG" id="KOG0141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_4_4_1"/>
    <dbReference type="InParanoid" id="B8LWV1"/>
    <dbReference type="OMA" id="EQPVMRQ"/>
    <dbReference type="OrthoDB" id="2588832at2759"/>
    <dbReference type="PhylomeDB" id="B8LWV1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED24584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="512" mass="57093" checksum="4B529851672A920C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWV8</accession>
    <name>B8LWV8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DUF221 domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_079460</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341978.1">
        <property type="nucleotide sequence ID" value="XM_002341937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWV8"/>
    <dbReference type="FunCoup" id="B8LWV8">
        <property type="interactions" value="177"/>
    </dbReference>
    <dbReference type="GeneID" id="8107653"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_079460"/>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002458_2_1_1"/>
    <dbReference type="InParanoid" id="B8LWV8"/>
    <dbReference type="OMA" id="PKRYYAH"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="PhylomeDB" id="B8LWV8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF53">
        <property type="entry name" value="DUF221 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="562"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="634"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="700"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="52"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="224"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="423"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="765"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED24591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="865" mass="98092" checksum="400B3C8BBD89F9AC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWX4</accession>
    <name>B8LWX4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phenol 2-monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_079620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341994.1">
        <property type="nucleotide sequence ID" value="XM_002341953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWX4"/>
    <dbReference type="STRING" id="441959.B8LWX4"/>
    <dbReference type="GeneID" id="8103893"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_079620"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_9_2_1"/>
    <dbReference type="InParanoid" id="B8LWX4"/>
    <dbReference type="OMA" id="VRFCDSK"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="PhylomeDB" id="B8LWX4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006144">
        <property type="entry name" value="PRK08294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF10">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="5"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="402"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED24607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="608" mass="67893" checksum="38262D7E5B0EE364" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXH3</accession>
    <name>B8LXH3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Eukaryotic translation initiation factor eIF1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_066950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EIF1AD family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340641.1">
        <property type="nucleotide sequence ID" value="XM_002340600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXH3"/>
    <dbReference type="STRING" id="441959.B8LXH3"/>
    <dbReference type="GeneID" id="8101182"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_066950"/>
    <dbReference type="eggNOG" id="KOG2925">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106477_4_0_1"/>
    <dbReference type="InParanoid" id="B8LXH3"/>
    <dbReference type="OMA" id="WRKQSYW"/>
    <dbReference type="OrthoDB" id="1738325at2759"/>
    <dbReference type="PhylomeDB" id="B8LXH3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039294">
        <property type="entry name" value="EIF1AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21641:SF0">
        <property type="entry name" value="RNA-BINDING PROTEIN EIF1AD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21641">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="5">
        <location>
            <begin position="5"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED23254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="138" mass="15669" checksum="AC0D40BAF61E6379" modified="2009-03-03" version="1">MGPPKRKVLATAEEGLYPPETLLEGHQIARIIKATGNNLYSVEWPSKQTALVELSARFRSKIWMKRGSYVVVDTNALDGRENKIAGEIVNVVRDEKAWRKAAFWPKEFVKQSYLPSDSEDEEESRVGKMPSSDEEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXJ1</accession>
    <name>B8LXJ1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA repair protein RAD50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSTA_078500</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341877.1">
        <property type="nucleotide sequence ID" value="XM_002341836.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B8LXJ1">
        <property type="interactions" value="1035"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LXJ1"/>
    <dbReference type="GeneID" id="8106219"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_078500"/>
    <dbReference type="eggNOG" id="KOG0962">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006184_0_0_1"/>
    <dbReference type="InParanoid" id="B8LXJ1"/>
    <dbReference type="OMA" id="FSDYYYR"/>
    <dbReference type="OrthoDB" id="18797at2759"/>
    <dbReference type="PhylomeDB" id="B8LXJ1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007534">
        <property type="term" value="P:gene conversion at mating-type locus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035753">
        <property type="term" value="P:maintenance of DNA trinucleotide repeats"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990426">
        <property type="term" value="P:mitotic recombination-dependent replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062176">
        <property type="term" value="P:R-loop processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010520">
        <property type="term" value="P:regulation of reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120290">
        <property type="term" value="P:stalled replication fork localization to nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000947">
        <property type="entry name" value="DNA repair protein RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001195">
        <property type="entry name" value="DNA repair protein rad50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004584">
        <property type="entry name" value="Rad50_eukaryotes"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00606">
        <property type="entry name" value="rad50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13558">
        <property type="entry name" value="SbcC_Walker_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="16">
        <location>
            <begin position="34"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="239"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="333"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="498"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="737"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="871"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="937"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1049"/>
            <end position="1083"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EED24490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1328" mass="153695" checksum="FE505567DDA928B9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXL0</accession>
    <name>B8LXL0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4</fullName>
            <ecNumber evidence="6">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Carbon catabolite repressor protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Cytoplasmic deadenylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Glucose-repressible alcohol dehydrogenase transcriptional effector</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">TSTA_078660</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Acts as a catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="6"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341898.1">
        <property type="nucleotide sequence ID" value="XM_002341857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXL0"/>
    <dbReference type="FunCoup" id="B8LXL0">
        <property type="interactions" value="451"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LXL0"/>
    <dbReference type="GeneID" id="8104419"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_078660"/>
    <dbReference type="eggNOG" id="KOG0620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016428_4_0_1"/>
    <dbReference type="InParanoid" id="B8LXL0"/>
    <dbReference type="OMA" id="PHYYARA"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="PhylomeDB" id="B8LXL0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09097">
        <property type="entry name" value="Deadenylase_CCR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000037">
        <property type="entry name" value="Glucose-repressible alcohol dehydrogenase transcriptional effector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000447">
        <property type="entry name" value="Glucose-repressible alcohol dehydrogenase transcriptional effector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF100">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12 26" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="25">
        <location>
            <begin position="383"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="38"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="98"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="583"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="24">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00031469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00033317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00045495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EED24511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="753" mass="84738" checksum="C84B90D21C536C99" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8LY21</accession>
    <name>B8LY21_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_067080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR48 family.</text>
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    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_002340653.1">
        <property type="nucleotide sequence ID" value="XM_002340612.1"/>
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    <dbReference type="STRING" id="441959.B8LY21"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_002197_0_0_1"/>
    <dbReference type="InParanoid" id="B8LY21"/>
    <dbReference type="OMA" id="PMWLGDV"/>
    <dbReference type="OrthoDB" id="2421129at2759"/>
    <dbReference type="PhylomeDB" id="B8LY21"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17041">
        <property type="entry name" value="Ubl_WDR48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001614">
        <property type="entry name" value="WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051246">
        <property type="entry name" value="WDR48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021772">
        <property type="entry name" value="WDR48/Bun107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862:SF14">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11816">
        <property type="entry name" value="DUF3337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="20"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="117"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="206"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="343"/>
            <end position="369"/>
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</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZN8</accession>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002479379.1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OMA" id="TIMQTEF"/>
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    <dbReference type="PhylomeDB" id="B8LZN8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046366">
        <property type="entry name" value="MPAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124:SF1">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="447" mass="52268" checksum="7C1065BE3C8E6F13" modified="2009-03-03" version="1">MDKMTKFSKLTTVLFSEITTGLSRLKLLENFTLQRGLIVALVLTTTHLIIASRLRYARMRYLMRKYPFKTRESFRFMTDQEAFEIQKHILQLEFPFTAVKSFQFALFRTYGIPTISSLLARTTEFSNPATAFKRYADTGVLIGQFMAFEPSSERAHEAIARTRFLHANYRKTGHILEDDMLYTLSLFALEPIRFVETYEWRKLSDLEKCAIGTYWKSLGDALDISYACLPSGSEMTDAKALERKRGFQDGLHWLEEIRVWSHAYEVQNMKPHQKNKQVADKTTDVLIYVLPGFLKLVGTQFVSFIMDDRLRAAIMYDPPYPLFATLFRAILAIRKYFLRYIALPRPYFLRYDLFDYSPDKDGLNYVKIWDAMPFYVKPTIWNRWGPSAWVKRLQGLPLPGDDGDKYFPQGFNTLDVGPRHFQGKGRTQMEQYRSQLVKERRGGCPFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZT3</accession>
    <name>B8LZT3_TALSN</name>
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        <recommendedName>
            <fullName evidence="9">C6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_080980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002477783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZT3"/>
    <dbReference type="STRING" id="441959.B8LZT3"/>
    <dbReference type="GeneID" id="8101403"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_080980"/>
    <dbReference type="eggNOG" id="ENOG502SPHU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011409_6_1_1"/>
    <dbReference type="InParanoid" id="B8LZT3"/>
    <dbReference type="OMA" id="AFKCRDW"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="PhylomeDB" id="B8LZT3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED20865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="61285" checksum="6B2EBE753DB7AE98" modified="2009-03-03" version="1"> </sequence>
</entry>
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    <accession>B8LZU8</accession>
    <name>B8LZU8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sphingoid long-chain base transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_081130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477843.1">
        <property type="nucleotide sequence ID" value="XM_002477798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZU8"/>
    <dbReference type="STRING" id="441959.B8LZU8"/>
    <dbReference type="GeneID" id="8101418"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_081130"/>
    <dbReference type="eggNOG" id="ENOG502QU4U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033465_6_1_1"/>
    <dbReference type="InParanoid" id="B8LZU8"/>
    <dbReference type="OMA" id="RIKQRSY"/>
    <dbReference type="OrthoDB" id="4521223at2759"/>
    <dbReference type="PhylomeDB" id="B8LZU8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED20880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="342" mass="37784" checksum="B33AEFEB429E0E62" modified="2009-03-03" version="1">MSDPATTITAPPPYITSSQQCTLEICPLSYAHTTYLPNLGGNAFFVAVFALFIPIQIYLGVRTRTWGYMVGMVCGLILEVLGYIGRIKMRDNPFIDRWFEMYIISLTIAPAFLSAAIYLSLARIVSVYSIELTRIKQRGYTLIFVTCDIFSLLLQAAGGAITTSNDNSTVQAGINIMIAGLSTQVASLTLYLGICLDFAFRVYRLNSQKQSGHMFRLVGKRHSSALSNDEEHEDDHGHAATGLNPDFASLRTSRKWHIFLVCQGLATICIYIRCIFRVAELSGGFNGHLANDEVTFMVLEGAMITIATAALSFWGHPGIGFAGRWDELNYPLFSKKKRANSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZV5</accession>
    <name>B8LZV5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF895 domain membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_081200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477850.1">
        <property type="nucleotide sequence ID" value="XM_002477805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZV5"/>
    <dbReference type="GeneID" id="8101425"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_081200"/>
    <dbReference type="eggNOG" id="KOG3098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030884_2_1_1"/>
    <dbReference type="InParanoid" id="B8LZV5"/>
    <dbReference type="OMA" id="VWQHSLT"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="PhylomeDB" id="B8LZV5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF4">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED20887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="53474" checksum="E3E11504EEA43D16" modified="2009-03-03" version="1">MADVNTDKKIPVPDFQDDSFPVYQQDTLSVGATHEVNMEEYRATVPLWKRVWQHSLTQMILLSIQAFCGPAMSDAITGLGGGGLATPKVSNISTAIRYAMIAIVCLMGGPLVNKIGVKWALVLGSLSFPIQGSAYYCNSKFGNQWYLILSGAISGVGTACWYVAEAGAIMTLAPSGARGKYLALWIVSRNLGQLVGGAINMSKNHHPGAEGGITPDTYIAFVIIECLALPFALLISPFEKVVRSDGTKIHMAEALSTKQEFKRILKTVTSSLIVLSSIWAFWSFFYSGSWSTYLGVYFSVRVRALSSLISPFFCIIGCFALGFILDMKNLSQRRRAQIGLYTVAILNVGVYIWSIIMQVKFNRHNPGKIDWSDHLYASAFLPYFFVQTTGPMSQSYMYWLLSSFATDAQENVRNGAVFRCIEAVGQAVAYGMNTQTKSSPLIGFCVTFGLLGASMLPMIMLVNTTPDRIPADVIAEAQDTARQKIEGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8M076</accession>
    <name>B8M076_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sphingomyelin phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_084050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts sphingomyelin to ceramide.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478136.1">
        <property type="nucleotide sequence ID" value="XM_002478091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M076"/>
    <dbReference type="STRING" id="441959.B8M076"/>
    <dbReference type="GeneID" id="8101498"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_084050"/>
    <dbReference type="eggNOG" id="KOG3770">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014743_1_0_1"/>
    <dbReference type="InParanoid" id="B8M076"/>
    <dbReference type="OMA" id="VWSQTRK"/>
    <dbReference type="OrthoDB" id="282973at2759"/>
    <dbReference type="PhylomeDB" id="B8M076"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006685">
        <property type="term" value="P:sphingomyelin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011160">
        <property type="entry name" value="Sphingomy_PDE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF34">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000948">
        <property type="entry name" value="Sphingomy_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877467" description="Sphingomyelin phosphodiesterase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="37"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="41"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="169"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="544"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000948-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000948-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED21173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="630" mass="68469" checksum="0A0B08DD9C71374D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8M137</accession>
    <name>B8M137_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">xylan 1,4-beta-xylosidase</fullName>
            <ecNumber evidence="14">3.2.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">1,4-beta-D-xylan xylohydrolase xlnD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Beta-xylosidase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Beta-xylosidase xlnD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Xylobiase xlnD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TSTA_082120</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Xylan 1,4-beta-xylosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of (1-&gt;4)-beta-D-xylans, to remove successive D-xylose residues from the non-reducing termini.</text>
            <dbReference type="EC" id="3.2.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="14"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477942.1">
        <property type="nucleotide sequence ID" value="XM_002477897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M137"/>
    <dbReference type="STRING" id="441959.B8M137"/>
    <dbReference type="GeneID" id="8104850"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_082120"/>
    <dbReference type="eggNOG" id="ENOG502QQ55">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_5_3_1"/>
    <dbReference type="InParanoid" id="B8M137"/>
    <dbReference type="OMA" id="GLPNYQV"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="PhylomeDB" id="B8M137"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000007">
        <property type="entry name" value="Exo-1,4-beta-xylosidase xlnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF13">
        <property type="entry name" value="EXO-1,4-BETA-XYLOSIDASE XLND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 19" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877483" description="xylan 1,4-beta-xylosidase" evidence="19">
        <location>
            <begin position="22"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="20">
        <location>
            <begin position="696"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EED20979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="797" mass="87107" checksum="7A5A18C791D8F1ED" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1A2</accession>
    <name>B8M1A2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_082770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478007.1">
        <property type="nucleotide sequence ID" value="XM_002477962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1A2"/>
    <dbReference type="STRING" id="441959.B8M1A2"/>
    <dbReference type="GeneID" id="8105155"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_082770"/>
    <dbReference type="HOGENOM" id="CLU_2656131_0_0_1"/>
    <dbReference type="InParanoid" id="B8M1A2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED21044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="76" mass="8627" checksum="ED20065FC9418980" modified="2009-03-03" version="1">MRVIDAARKQGHTVEMHLIERYADRVECSVDSVNKLGGILKLMKRGAVVIKRGSRDSKGLIYPVPQYFLRAYFSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1P1</accession>
    <name>B8M1P1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-1,2-mannosyltransferase (Kre2), putative</fullName>
            <ecNumber evidence="6">2.4.1.131</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_093740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.131" evidence="6"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479091.1">
        <property type="nucleotide sequence ID" value="XM_002479046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1P1"/>
    <dbReference type="FunCoup" id="B8M1P1">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M1P1"/>
    <dbReference type="GeneID" id="8102618"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_093740"/>
    <dbReference type="eggNOG" id="KOG4472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024327_4_1_1"/>
    <dbReference type="InParanoid" id="B8M1P1"/>
    <dbReference type="OMA" id="YCDIHYD"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="PhylomeDB" id="B8M1P1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED22128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="404" mass="47354" checksum="74CBCE567E24160D" modified="2009-03-03" version="1">MSSNSGKYIRYVLFAVFGLAILAFITKSSLPLPSDYAFSLLPETQQSETNDKPNNEAAAIDPTSQTPANTGPPPLTPSGDRINATFVTLARNNDLWEIAKSIREVEDRFNRNYHYDWVFLNDKPFDEEFKKLTSVLASGKTHYGLIPKEHWSYPEWIDQDKARAVREDMKERKIIYGDSESYRHMCRYESGFFFRHELMLNYEYYWRVEPSIQLFCDISFDPFRYMMENKKKYSFVLSLYEYYETIPTLWDSTKKFMAANPQHIAEDNSMGFLSDDGGETYNKCHFWSNFEIGSLEWLRSDAYIDFFTSLDHDGGFFYERWGDAPVHSIAAGLLLNKEEIHFFNEIAYYHVPFTHCPTGEQTRLDLKCHCNPADNFDWKGYSCTSRYFHINDIPKPEGYEKETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1P6</accession>
    <name>B8M1P6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_093790</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479096.1">
        <property type="nucleotide sequence ID" value="XM_002479051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1P6"/>
    <dbReference type="FunCoup" id="B8M1P6">
        <property type="interactions" value="677"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M1P6"/>
    <dbReference type="GeneID" id="8103707"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_093790"/>
    <dbReference type="eggNOG" id="KOG0953">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010647_1_3_1"/>
    <dbReference type="InParanoid" id="B8M1P6"/>
    <dbReference type="OMA" id="FCEMIIF"/>
    <dbReference type="OrthoDB" id="6692397at2759"/>
    <dbReference type="PhylomeDB" id="B8M1P6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045025">
        <property type="term" value="C:mitochondrial degradosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17913">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18805">
        <property type="entry name" value="SF2_C_suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000269">
        <property type="entry name" value="ATP-dependent RNA helicase SUPV3L1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000957">
        <property type="entry name" value="ATP-dependent RNA helicase SUV3L, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055206">
        <property type="entry name" value="DEXQc_SUV3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022192">
        <property type="entry name" value="SUV3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044774">
        <property type="entry name" value="Suv3_DEXQc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22527">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12513">
        <property type="entry name" value="SUV3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="337"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="696"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="696"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="706"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="733"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED22133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="746" mass="84007" checksum="3DE853B8975E4C90" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1W6</accession>
    <name>B8M1W6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved fungal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_085750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478307.1">
        <property type="nucleotide sequence ID" value="XM_002478262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1W6"/>
    <dbReference type="GeneID" id="8104540"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_085750"/>
    <dbReference type="eggNOG" id="ENOG502S85Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067863_0_0_1"/>
    <dbReference type="InParanoid" id="B8M1W6"/>
    <dbReference type="OMA" id="GQPPKTC"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="PhylomeDB" id="B8M1W6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021706">
        <property type="entry name" value="DUF2990"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021851">
        <property type="entry name" value="DUF3455"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567:SF1">
        <property type="entry name" value="CONSERVED FUNGAL PROTEIN (AFU_ORTHOLOGUE AFUA_1G14230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567">
        <property type="entry name" value="MALATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G13800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11693">
        <property type="entry name" value="DUF2990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11937">
        <property type="entry name" value="DUF3455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877236" evidence="1">
        <location>
            <begin position="18"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="254" mass="26655" checksum="E7624AF00265976D" modified="2009-03-03" version="1">MHFNGLVLASLATAAVAAPTSNVFNDVYNFDATLEEFYSRVSAHIGRFADGPPPTNCDLSKVSVPSSSLPPATGTLKYVAIGRGTQNYTCADATADTLPSQIGAVANLYDASCIAANYPDLLDLATDIVLNFSLPAPGVQTPLAPANVEILGHHYFETTTTPTFNLNTTPDKQFGVALTSKKNSTTAPQGSIIGQFNVGYGAVPWLYLTSITGTTDGITSVYRVKTAGGAAPATCSGQPAAFQIQYSAQYFFYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1X1</accession>
    <name>B8M1X1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_085800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478312.1">
        <property type="nucleotide sequence ID" value="XM_002478267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1X1"/>
    <dbReference type="FunCoup" id="B8M1X1">
        <property type="interactions" value="1099"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M1X1"/>
    <dbReference type="GeneID" id="8104545"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_085800"/>
    <dbReference type="eggNOG" id="KOG3582">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126658_3_0_1"/>
    <dbReference type="InParanoid" id="B8M1X1"/>
    <dbReference type="OMA" id="VDYMRDQ"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="PhylomeDB" id="B8M1X1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF39">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="41"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED21349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="110" mass="12272" checksum="49B83252A20F8195" modified="2009-03-03" version="1">MSSDTSAHNNDHSRDSVSSNNETPGVGADGNQDKPRLTEQEKKNNHIASEQKRRAAIREGFDRLTELVPGLEGQGRSESVVLKKTLQERRELIAEIERSGGQVDESFRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1Y7</accession>
    <name>B8M1Y7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein phosphatase 2C, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_085960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478328.1">
        <property type="nucleotide sequence ID" value="XM_002478283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1Y7"/>
    <dbReference type="STRING" id="441959.B8M1Y7"/>
    <dbReference type="GeneID" id="8104561"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_085960"/>
    <dbReference type="eggNOG" id="KOG0698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009813_0_0_1"/>
    <dbReference type="InParanoid" id="B8M1Y7"/>
    <dbReference type="OrthoDB" id="416093at2759"/>
    <dbReference type="PhylomeDB" id="B8M1Y7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000098">
        <property type="entry name" value="Protein phosphatase 2C, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF589">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE [ACETYL-TRANSFERRING]]-PHOSPHATASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="628"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="570"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1067"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="570"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="588"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1075"/>
            <end position="1093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED21365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1093" mass="121835" checksum="D82FF79AA4DBC1A2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8M244</accession>
    <name>B8M244_TALSN</name>
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        <recommendedName>
            <fullName evidence="4">25S rRNA (Uridine(2843)-N(3))-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_087440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478471.1">
        <property type="nucleotide sequence ID" value="XM_002478426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M244"/>
    <dbReference type="FunCoup" id="B8M244">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M244"/>
    <dbReference type="GeneID" id="8100873"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_087440"/>
    <dbReference type="eggNOG" id="ENOG502QR34">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028833_1_0_1"/>
    <dbReference type="InParanoid" id="B8M244"/>
    <dbReference type="OMA" id="DMRYQVH"/>
    <dbReference type="OrthoDB" id="6419443at2759"/>
    <dbReference type="PhylomeDB" id="B8M244"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021463">
        <property type="entry name" value="Methyltransf_34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11312">
        <property type="entry name" value="Methyltransf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="45198" checksum="6D1AF10016607743" modified="2009-03-03" version="1">MAGPTTKPGKSKGKPKPAKKQQQSVSTKKPSSRKEDTTTEDQIDFSSAANSISSDVQQALLNVFKHALFSSAEDGEEDMRTQIQQLKTYLYNRDFESAFADASPSLLRAYALRWSASRCLAYCGLFRGVLDFGFAFDGVQDGGGEEEVAVLCIGGGAGAEIVALAGAWRVLYDEDSANAVEGIERLSLNESVSEGNKRKRKLSITAIDIAEWSDVVHRLTTAIHSNVPGTKTCPTPLIQDRGSINISFQKLDILCLSEENLRSLLHRQRLISLMFTLNELFSTSISKTTQLLLRITDIASPGTMLMVVDSPGSYSTLSLSKSQVSDTQQQQRQYPMKFLLDHTLLNVAEASWEKIVSQNSRWFRKDVNNKLHYNVDLEGGQGFIKLEDMRFQIHVYRRLAPSSNEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8M368</accession>
    <name>B8M368_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxidoreductase, 2OG-Fe(II) oxygenase family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_092900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479007.1">
        <property type="nucleotide sequence ID" value="XM_002478962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M368"/>
    <dbReference type="STRING" id="441959.B8M368"/>
    <dbReference type="GeneID" id="8099468"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_092900"/>
    <dbReference type="eggNOG" id="KOG2731">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029471_0_0_1"/>
    <dbReference type="InParanoid" id="B8M368"/>
    <dbReference type="OMA" id="CEVIRLR"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="PhylomeDB" id="B8M368"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004574">
        <property type="entry name" value="Alkb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557:SF2">
        <property type="entry name" value="NUCLEIC ACID DIOXYGENASE ALKBH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-ketoglutarate-dependent dioxygenase AlkB-like" evidence="6">
        <location>
            <begin position="249"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604574-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED22044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="332" mass="37513" checksum="8956AE3919624777" modified="2009-03-03" version="1">MATIKGLNAHDRPPEKVREVYKKYLRIKMPEIDQDPEIIDLEKLDVDNLPSPYAISGSLDSADLRLSFDEFVGVHKNSSGGKDHHGGGLIEDIPILTHSKVTGLHMIPALYPPTVQSKLLDLMLHRDLSNPEHQTNLHLHYDIEYPHATGQSADKQNESPISFFGADPTTTFAPKDPHVHKPMTIQNMLDKKLRWITFGGQYNWTTKVYPEGQPPPFPEDIAHLLRASFPETEAQAAIVNFYSANDTFIGCDALFMISHDDGEGCEVIRLRSGDAVYMSGQSRFAWHGVPKIIPDTCPKWLCDWPGPGYPYWQGWMGRKRVNLNVRQMMESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3X8</accession>
    <name>B8M3X8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PAP2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_039220</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481155.1">
        <property type="nucleotide sequence ID" value="XM_002481110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3X8"/>
    <dbReference type="STRING" id="441959.B8M3X8"/>
    <dbReference type="GeneID" id="8109260"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_039220"/>
    <dbReference type="eggNOG" id="KOG3030">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021458_2_0_1"/>
    <dbReference type="InParanoid" id="B8M3X8"/>
    <dbReference type="OMA" id="WNAGWMG"/>
    <dbReference type="OrthoDB" id="10030083at2759"/>
    <dbReference type="PhylomeDB" id="B8M3X8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000042">
        <property type="entry name" value="PAP2 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF154">
        <property type="entry name" value="PAP2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G09730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="114"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="235"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED20721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="387" mass="41794" checksum="7D1917C4F82C3861" modified="2009-03-03" version="1">MSANQVKPAIVRISKLLVTSYILDWILIAGLAGIGGGFSSLTPSQRPFSLTDPDISLPYKPKDTVSSGVLIVIGLVIPAAIILLFSFALVPSLHALKGTPFALIWRRKIWEWNAGWMGLALALAATFTATEGLKDLIGKPRPDLIGRCDPDLSQIERYAVGGLGALLQGAPTFVTYEICRNQGSELKNDGFAAWPSGHSSFSFAGMLYLTLWLCAKFSVSFPYLGPLPFGTRSPAAAAPPPPAAPPANSHLQKAESESTNSFTTDTLPTSTSPRDQGAAPPVYLQILVFVPICVAFFVACSRYHDHRHAGFDIISGSALGIFFAYVGFHMYHLPLRRSDGWAWSARSRRHAFFRGVGYADLTVTEGWAGQEPISAVAENEVRGEEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4K4</accession>
    <name>B8M4K4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Allantoate permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_025200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479634.1">
        <property type="nucleotide sequence ID" value="XM_002479589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4K4"/>
    <dbReference type="GeneID" id="8106737"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_025200"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="B8M4K4"/>
    <dbReference type="OMA" id="FSPIANC"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="PhylomeDB" id="B8M4K4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="9"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED19200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="449" mass="49679" checksum="844D7A6230C5C6DA" modified="2009-03-03" version="1">MTQTRYLTAIFSLGFLYMFSYIDRGNIGNAYTAGMGADWGITSNQYSWVLTAYYLTYIVFQWFILLWKVVSLPTWVALMALGWGAMSMIQTVTSSFAGLMAVRCLLGVFEAGFAPGVALFLSFFYHRSEMAFRYGLFISFSAIANCFASAMAYGIVHAKTSIASWKLLFVIEGIPTLVIVPIAYFLLPKGPGECRFLNQKENEIIRLRAVQGRGREEKGRLNFRHLFIACYDYKNYFQAVIVLCLNTAFAALPAFLPTIIKDIGYSSIQSQGLSAPPYFIAFLICLGVSFLSDRYGNRSIFLTTLSIVGAVGYLIEALVKTEGVRYFATYLICGGVFSAVALAFTWVTDNQGSASKRGAGLVIFGMIGQTGSIAGSRFFPSEEGPYYIKGMGISAGLLLFAAILSQVLRFLMARENKRRDALYGYVDIKNMPDEVGDAGDDHPSFRFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5D8</accession>
    <name>B8M5D8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GAF domain nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_030130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the free Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480178.1">
        <property type="nucleotide sequence ID" value="XM_002480133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5D8"/>
    <dbReference type="STRING" id="441959.B8M5D8"/>
    <dbReference type="GeneID" id="8106580"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_030130"/>
    <dbReference type="eggNOG" id="ENOG502RXXR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_516979_0_0_1"/>
    <dbReference type="InParanoid" id="B8M5D8"/>
    <dbReference type="OMA" id="KWEGEVM"/>
    <dbReference type="OrthoDB" id="15735at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033745">
        <property type="term" value="F:L-methionine-(R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12193">
        <property type="entry name" value="bZIP_GCN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000614">
        <property type="entry name" value="FRMsr_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF15">
        <property type="entry name" value="FREE METHIONINE-R-SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01320">
        <property type="entry name" value="UPF0067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="4">
        <location>
            <begin position="581"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="253"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="497"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="599"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="511"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED19744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="645" mass="70587" checksum="4C16FDC900AE0E08" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5E4</accession>
    <name>B8M5E4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Repressor of RNA polymerase III transcription MAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_030190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480184.1">
        <property type="nucleotide sequence ID" value="XM_002480139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5E4"/>
    <dbReference type="STRING" id="441959.B8M5E4"/>
    <dbReference type="GeneID" id="8106586"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_030190"/>
    <dbReference type="eggNOG" id="KOG3104">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037043_1_0_1"/>
    <dbReference type="InParanoid" id="B8M5E4"/>
    <dbReference type="OMA" id="GCDLWTV"/>
    <dbReference type="OrthoDB" id="277029at2759"/>
    <dbReference type="PhylomeDB" id="B8M5E4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000994">
        <property type="term" value="F:RNA polymerase III core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1000.50:FF:000004">
        <property type="entry name" value="Repressor of RNA polymerase III transcription MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="entry name" value="Repressor of RNA polymerase III transcription Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504:SF0">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037240">
        <property type="entry name" value="RNA_polIII_Trep_MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="314" mass="35660" checksum="A6D9A22985B47D50" modified="2009-03-03" version="1">MKYLPLPQIEEVSNALNFDTPDLHVVGGCDLYITKAASDDRKLYHKIEQSLESQYESLLKLSASLSPPTKASAPNNVALSLNLSRSSPFGPLTEHSSRRTFAYLIATLNASHPDYDYSHVLRPTDFRRERSLKKVMNTLDMTLHNLRPHLRDDGSPSPPTDSFSGSYSTSSTTAWGPRMWKLIDEEMSLNDCAIFSYSPEDDMNDDDDGAIWSHNYFFFNKQRKRVCYVYLRGIPIMSHDDDEIMAMWEDDGVATPVGKRIPDDSYYTPDITAKKRQRYWLGDLASDDEPISSSTRRIGAVRAMSEEMVDSMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5U2</accession>
    <name>B8M5U2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bicyclomycin resistance protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_033160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480503.1">
        <property type="nucleotide sequence ID" value="XM_002480458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5U2"/>
    <dbReference type="STRING" id="441959.B8M5U2"/>
    <dbReference type="GeneID" id="8105054"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_033160"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_1_0_1"/>
    <dbReference type="InParanoid" id="B8M5U2"/>
    <dbReference type="OMA" id="PLWRKWS"/>
    <dbReference type="OrthoDB" id="4226984at2759"/>
    <dbReference type="PhylomeDB" id="B8M5U2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF163">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="53"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED20069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="497" mass="54716" checksum="261A86B241BE70B7" modified="2009-03-03" version="1">MINNLKDSEIIAYDADNNFTPQPLVKEKDEEIVPLPEQWDDPTAWPLWRKWSIVICVALMYMLANFGTIIIVPGVPLILSEFNESGKLYQPLIVSIWELGEGVGSFLVGPLSERYGRKIIYHIGNAIFILCSVASALSVNVSMLVAFRFINGMAVTVLTLSPSIIGDLFVREERGTAMAVAISVPLIGPCVAPIVGGYVASALGWRWAIWLIAIAVGCVSMFSLLVFKETYKSKIQEKQSRRNPNSGPDSPPAQEIARNESPQETKLQSFLRPVRLLFSSPVVLVTSLFTSLIYGFSYLILTTLAEIMQETYGFGSGPVGLTFLGRAIGNLIGLALYGLTSDRYLEYRRRKAGNSIPEDRLPLMILGTALLPVGLFLYGWSAHFHVQWSVPLIGTGIVGLSMLLTKLPTDNYLVDAFAPQGTSASILSADATLKALFGAIFPLLGPSLYRNLGLGWGNSLLAFIGLVFLPLFIILWREGQELRTEGWGYLNVMMKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6K6</accession>
    <name>B8M6K6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidate cytidylyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_027620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479902.1">
        <property type="nucleotide sequence ID" value="XM_002479857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6K6"/>
    <dbReference type="FunCoup" id="B8M6K6">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M6K6"/>
    <dbReference type="GeneID" id="8109681"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_027620"/>
    <dbReference type="eggNOG" id="KOG4453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031477_2_0_1"/>
    <dbReference type="InParanoid" id="B8M6K6"/>
    <dbReference type="OMA" id="NYWREMS"/>
    <dbReference type="OrthoDB" id="5673at2759"/>
    <dbReference type="PhylomeDB" id="B8M6K6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037997">
        <property type="entry name" value="Dgk1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303:SF1">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="476" mass="51886" checksum="232DACB6205F77FE" modified="2009-03-03" version="1">MSDVDVENYHGRSFSADNDNHKQTANIQSLTPVPTLLSALLANSYSADCHPHSPSRLLHRAANGVIALPALPLLLTDAVEMSSPHAVPTTPRVISPSPTPSDASEQRDGYLAPVTRSAARRQRFNTDTQAIPEEDQNNDSEHQSRSGPRNPSSRSGAAGTARRRGSTRKTPQSASSPVVKSQPLVGANGKPSSNGYLSPYANLQDRWRDLSRSPSPLGLIPLHENYRTFIHKHEIPRKLLHVSIGFVTLEFYRRGVQTFEITPWLLSALIPIAATDILRHRYDSVNQLYIRSLGALMRESEVKGYNGVIWYLLGAYIVLRAFPKDVGVMGVLLLSWCDTAASTFGRLYGKHTIKLRHGKSLAGTAAAFLTGVVTALFFWGAFVPSIGTFPNDPEDAFMFSGRLNYFPESIRNLVGWTSSGYQSSVITGPLALGVVSVVSGIVAAGSEFIDLFGWDDNLTIPVLSGLGFWGFLKLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6W5</accession>
    <name>B8M6W5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta-mannosidase B</fullName>
            <ecNumber evidence="3">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mannanase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_034240</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="3"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480619.1">
        <property type="nucleotide sequence ID" value="XM_002480574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6W5"/>
    <dbReference type="STRING" id="441959.B8M6W5"/>
    <dbReference type="GeneID" id="8097840"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_034240"/>
    <dbReference type="eggNOG" id="KOG2230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005015_1_1_1"/>
    <dbReference type="InParanoid" id="B8M6W5"/>
    <dbReference type="OMA" id="DWGPVIM"/>
    <dbReference type="OrthoDB" id="2866996at2759"/>
    <dbReference type="PhylomeDB" id="B8M6W5"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000118">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000050">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="13">
        <location>
            <begin position="12"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="11">
        <location>
            <begin position="204"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="12">
        <location>
            <begin position="682"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED20185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="852" mass="97974" checksum="3E06F70650BE611A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8M837</accession>
    <name>B8M837_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TeaA receptor TeaR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_032540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480433.1">
        <property type="nucleotide sequence ID" value="XM_002480388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M837"/>
    <dbReference type="STRING" id="441959.B8M837"/>
    <dbReference type="GeneID" id="8099867"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_032540"/>
    <dbReference type="eggNOG" id="ENOG502SP8D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023414_1_1_1"/>
    <dbReference type="InParanoid" id="B8M837"/>
    <dbReference type="OMA" id="PINRPEG"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="PhylomeDB" id="B8M837"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="55239" checksum="0FE2005338FEDEE3" modified="2009-03-03" version="1">MAGTATAISSTDALSSPSSSSTAWDLAVPLGPEADTITPKRTSNESSSLYNKPNYRHRTPNGHPRSRTSSQTGSRRGSNAHDSYGREIGPMTKDMADAYSNGHVWKGDYSGKPPVDTEGMPSDDNWIHRDKLARIESEELQQAAMRIQHRVRTGSKSSSMRGRSHDTQSFNGTITTPPEQTEPWAGSRQQLESPIPLEDSDEQEIEVERRNWDLRRPEEIAASSSEVNDDSSSSKFYKSPALKKSSSRIPVLASSPHQVSSDPNEPSPEPADSTTPPLSTSRPSSRAGMLSQAQSSPTKKAPTKGTTTARKSSAPPNNRKPSGAAKQRATSGSSTSRDRPVTRSGDNRPTTSANPPEGDPPWLATMYKPDPRLPPDQQMLPTHAKRMQQELWEKEGKTPTTYDREFAPLAVQPDEPAQLAPAPEEKNETTTDGDNSATESTSQWPLQPKSPEPTRPGTSGTNYSTMPKVQTAPQIPLPTTPRVPANMFPPPPEEKEKVEKGCGCCIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8I9</accession>
    <name>B8M8I9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Inositol oxygenase</fullName>
            <ecNumber evidence="4 14">1.13.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 14">Myo-inositol oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_037220</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>myo-inositol + O2 = D-glucuronate + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="EC" id="1.13.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="13 14">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the myo-inositol oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.99.1" evidence="4 14"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480936.1">
        <property type="nucleotide sequence ID" value="XM_002480891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8I9"/>
    <dbReference type="STRING" id="441959.B8M8I9"/>
    <dbReference type="GeneID" id="8100568"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_037220"/>
    <dbReference type="eggNOG" id="KOG1573">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050259_0_1_1"/>
    <dbReference type="InParanoid" id="B8M8I9"/>
    <dbReference type="OMA" id="RYNTKYG"/>
    <dbReference type="OrthoDB" id="5151075at2759"/>
    <dbReference type="PhylomeDB" id="B8M8I9"/>
    <dbReference type="UniPathway" id="UPA00111">
        <property type="reaction ID" value="UER00527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050113">
        <property type="term" value="F:inositol oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007828">
        <property type="entry name" value="Inositol_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588:SF0">
        <property type="entry name" value="INOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588">
        <property type="entry name" value="MYOINOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05153">
        <property type="entry name" value="MIOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="122"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="258"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED20502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="357" mass="41038" checksum="B483F62AE687E856" modified="2009-03-03" version="1">MAPGATFPTAAAAGEFTKRDGKALETLSDNIDAVNILKPLTTTTTTTTEKGLYDESVFDKTKDKSQFRQYETACARVKSFYKEQHTKQTVAYNLLARNKFRSSTRARMSVWQAIERLNTLIDDSDPDTSLSQIEHLLQSAEAIRRDGKPRWMQLTGLIHDLGKLLYFFDGIAEGQWDVVGDTFPVGCAFDDRIIYGRESFVSNPDYGHEVYDRGLGIYFPGIGLDNVMLSWGHDEYLYHVVKGQSTLPDEALAMIRYHSFYPWHNAGAYEELMNEKDKEMLRAVRAFNPYDLYSKSDELPKVEELRPYYEELIDEFFPERYMMVVSSEKESINMKFKSSKVKTWVSSRSEPVNENQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8X2</accession>
    <name>B8M8X2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Platelet-activating factor acetylhydrolase isoform 1B alpha subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_038410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481069.1">
        <property type="nucleotide sequence ID" value="XM_002481024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8X2"/>
    <dbReference type="STRING" id="441959.B8M8X2"/>
    <dbReference type="GeneID" id="8107883"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_038410"/>
    <dbReference type="eggNOG" id="KOG0272">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_6_0_1"/>
    <dbReference type="InParanoid" id="B8M8X2"/>
    <dbReference type="OMA" id="AGDNILW"/>
    <dbReference type="OrthoDB" id="4226663at2759"/>
    <dbReference type="PhylomeDB" id="B8M8X2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055442">
        <property type="entry name" value="Beta-prop_EML-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23414">
        <property type="entry name" value="Beta-prop_EML_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="396"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="443"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like second beta-propeller" evidence="4">
        <location>
            <begin position="452"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="485"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="527"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="569"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED20635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="723" mass="81423" checksum="AAA5B095A8E7272D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8Z3</accession>
    <name>B8M8Z3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pogo transposable element, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_111320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481280.1">
        <property type="nucleotide sequence ID" value="XM_002481235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8Z3"/>
    <dbReference type="GeneID" id="8109812"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_111320"/>
    <dbReference type="eggNOG" id="KOG3105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_4_0_1"/>
    <dbReference type="InParanoid" id="B8M8Z3"/>
    <dbReference type="OMA" id="NSANGWT"/>
    <dbReference type="OrthoDB" id="4457643at2759"/>
    <dbReference type="PhylomeDB" id="B8M8Z3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="107"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="461" mass="52543" checksum="EFA42B6657B03133" modified="2009-03-03" version="1">MANYLLSQHGDQRVGDKWVYNLVQRRPEIESKFSRKYNYDRAKCEDPKIIQGHFDRVRDIISEYGILPEDIYNFDETGFAMGLCATAKVITGSDRYARPKLLQPGNREWVTAIEATNSTGWALPSYVIFKAKKNVRLGWFDELPDDWRINISDNGWTTDQIGLEWLKTHFIPLTSGRTLGTYSMLILDGHGSHLTAEFDRTCTDHKIIPVCMPPHSSHLLQPLDVGCFAVLKRYYGQLVEQRMRLGFNHIDKIGFLTAFHRLARTVAYKAQTIRNSFTATGLVPFNPDRVLQHLNIQLKTPTPPPSRSSNTASSCLQTPQNIRQFVRQSTTINKRINERTGSLNQNEEINQAVIRLSKAYEILANDALLVRKENRDLRAAHEKEKQKRKRSNKQISIEQGITREEAQVLVQGQVEASQAVTTAPAEPELPTSQAVVRRQFRCSGCNVEGHRINQCPNRTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9H1</accession>
    <name>B8M9H1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAP family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_115300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481723.1">
        <property type="nucleotide sequence ID" value="XM_002481678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9H1"/>
    <dbReference type="STRING" id="441959.B8M9H1"/>
    <dbReference type="GeneID" id="8101340"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_115300"/>
    <dbReference type="eggNOG" id="KOG1508">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038163_0_0_1"/>
    <dbReference type="InParanoid" id="B8M9H1"/>
    <dbReference type="OMA" id="RFTFEFK"/>
    <dbReference type="OrthoDB" id="19419at2759"/>
    <dbReference type="PhylomeDB" id="B8M9H1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="4">
        <location>
            <begin position="25"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="260"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="339"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED17731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="367" mass="41669" checksum="11E1EDB571E707A7" modified="2009-03-03" version="1">MSGDEAPSLWERISLPSIPKEVGRKISQLEQEFVRAELEQLRKQIPVLRPLYARRNALVASKELQDADFWPRVFANAPQEIDEYILASDAAVISQCLKNLTIERCDVDENGSGGDPRSVRFTFEFATGEEENPYFTNAQLVKEFHYRTKISKTPKGKRHVWEGYVSTPVRINWKKDQDLTKGLLDAACDLYEAEQKKGAGVDRTTLPEYEKLITKLEEASAEADALVGDEEEEADEEYLPGGVSFFNFFGYRGNTVTAEESAAAEKEEAERWQKIENGEKVDDEDDEDDDEDDDIDEEEESIATIEIFPAADDIAVALADDVWPNALKYYVQSYEVANDFDDEMDIEELDDDEGEDDEDRPAKKVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9T4</accession>
    <name>B8M9T4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_118530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482078.1">
        <property type="nucleotide sequence ID" value="XM_002482033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9T4"/>
    <dbReference type="STRING" id="441959.B8M9T4"/>
    <dbReference type="GeneID" id="8099777"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_118530"/>
    <dbReference type="eggNOG" id="ENOG502SIC9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027146_0_0_1"/>
    <dbReference type="InParanoid" id="B8M9T4"/>
    <dbReference type="OMA" id="MAIHARM"/>
    <dbReference type="OrthoDB" id="4360026at2759"/>
    <dbReference type="PhylomeDB" id="B8M9T4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED18086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="336" mass="38227" checksum="A7D4EE67832455A6" modified="2009-03-03" version="1">MAENNIIDRLRSSAFDLGEVRDALRGKAVPTVLEHRITRLCVIRGIRYHEQFAEDSELEQFRQYVPEVSRALTARAVMSNKIPSIPEARDRPYCISHPQVASQDTYRKLCQLCGAVSRDGSVAEEARASGSMEIFESIMRKPVRYRVTNDYTREITLQDPTTACLNDDNAIVFTLDIDQGINKPRDEERDPVIEGATVEESQDASDFDGMDYLYPFSGFDEKMFNITEDINVGEVDSEEPHLNYLPELLFQPLPADLPQGNKDLLILIAAYYGNSERYARLHRPRMIKGEPGCVVRGIYHNSMFSLWCATQTIPDWPASSHVTMAIHARMVVFLRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MA37</accession>
    <name>B8MA37_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquinone biosynthesis protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_121100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482358.1">
        <property type="nucleotide sequence ID" value="XM_002482313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MA37"/>
    <dbReference type="FunCoup" id="B8MA37">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MA37"/>
    <dbReference type="GeneID" id="8102449"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_121100"/>
    <dbReference type="eggNOG" id="KOG1236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_6_0_1"/>
    <dbReference type="InParanoid" id="B8MA37"/>
    <dbReference type="OMA" id="SMVRTHH"/>
    <dbReference type="OrthoDB" id="1290869at2759"/>
    <dbReference type="PhylomeDB" id="B8MA37"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13971">
        <property type="entry name" value="ADCK2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044095">
        <property type="entry name" value="ADCK2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052402">
        <property type="entry name" value="ADCK_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890:SF1">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2 (PREDICTED)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="216"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="307"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED18366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="699" mass="79297" checksum="53D26EB8B5EDF119" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAP3</accession>
    <name>B8MAP3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteasome regulatory particle subunit (RpnI), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_112950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S11 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481459.1">
        <property type="nucleotide sequence ID" value="XM_002481414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAP3"/>
    <dbReference type="FunCoup" id="B8MAP3">
        <property type="interactions" value="1354"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MAP3"/>
    <dbReference type="GeneID" id="8105760"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_112950"/>
    <dbReference type="eggNOG" id="KOG2908">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042989_0_0_1"/>
    <dbReference type="InParanoid" id="B8MAP3"/>
    <dbReference type="OMA" id="SFEDYWE"/>
    <dbReference type="OrthoDB" id="1093at2759"/>
    <dbReference type="PhylomeDB" id="B8MAP3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054179">
        <property type="entry name" value="PSD13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035298">
        <property type="entry name" value="PSMD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040798">
        <property type="entry name" value="Rpn9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22037">
        <property type="entry name" value="PSD13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18261">
        <property type="entry name" value="Rpn9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="175"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED17467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="381" mass="43483" checksum="9FF306C5D133DEAA" modified="2009-03-03" version="1">MEADKIPDFLADQRDQAPSSAQALFLDFEDYWERKLWHQLTDALVDFFQTPESAPQRLPIFKSFILSFADRINQLKFVSLGLLASTQCKDDQERLAFLTSLADRVDKPDSQDAYVYAVADVAGVKLRLQDYEGSRKDLDKSQKILDTFDSVETVVHAAFYKVNADYYHAKQEFASYYKNALLYLACVNLDDLSQEERISRAYDLSVAALVSDSIYNFGELLLHPILDSLTETPHAWLRDLLFAFNRGDLTAYDVLAGNISKNKLLESHRQFLYIKISLSALTEAVFRRPPHDRTMTFSTISAETKVQSDEIEHLIMKALSLGLIKGSIDQVAQIARINWVQPKVLDMKQIEGMRNRLKEWDTGVNQLGHWIEGVGRDVWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBI0</accession>
    <name>B8MBI0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_116340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481836.1">
        <property type="nucleotide sequence ID" value="XM_002481791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBI0"/>
    <dbReference type="STRING" id="441959.B8MBI0"/>
    <dbReference type="GeneID" id="8102026"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_116340"/>
    <dbReference type="eggNOG" id="ENOG502S4QH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067876_0_0_1"/>
    <dbReference type="InParanoid" id="B8MBI0"/>
    <dbReference type="OMA" id="TAQWHQW"/>
    <dbReference type="OrthoDB" id="10255576at2759"/>
    <dbReference type="PhylomeDB" id="B8MBI0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052618">
        <property type="entry name" value="ComplexI_NDUFA12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470">
        <property type="entry name" value="ADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED17844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="192" mass="22644" checksum="E488E3DEAB91426F" modified="2009-03-03" version="1">MSPVNSLWFKWKALKLPWRRSWVVGQDLSGNTFWEFRDAINTNRLRRIVKYNNKTHYGDVKITPQWHQWLRYVRQEPPSLEEQRRDIMRQIQIKKLAQIADEKWAAKPSYLDKPQTKQTSPATRTSDKTLHPTKTSDPRSERQPGVMNQVQGQEQIQQDASQKKTKALSRNVPTGPGEKWQPEAWTPDATRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBV5</accession>
    <name>B8MBV5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="4 12">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">5-proFAR isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_119940</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="4 12"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482230.1">
        <property type="nucleotide sequence ID" value="XM_002482185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBV5"/>
    <dbReference type="FunCoup" id="B8MBV5">
        <property type="interactions" value="221"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MBV5"/>
    <dbReference type="GeneID" id="8105268"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119940"/>
    <dbReference type="eggNOG" id="KOG3055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065050_0_0_1"/>
    <dbReference type="InParanoid" id="B8MBV5"/>
    <dbReference type="OMA" id="IEWNKTH"/>
    <dbReference type="OrthoDB" id="446074at2759"/>
    <dbReference type="PhylomeDB" id="B8MBV5"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04723">
        <property type="entry name" value="HisA_HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000110">
        <property type="entry name" value="1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011858">
        <property type="entry name" value="His6/HISN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02129">
        <property type="entry name" value="hisA_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090:SF2">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 12 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED18238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="256" mass="27989" checksum="0774A21B3BD5D7FE" modified="2009-03-03" version="1">MTKFRPCIDLHSGQVKQIVGGTLTTVDSELKTNYVSKLPASHYANLYRQHDLRGGHVVMLGPGNTGAAKEALKAWPGGLQVAGGITDENALYWIEQGAEKVIITSFLFPEGKFSLDRLKSVLSALGNDTSKLVLDLSCRKKDNTWYVAMNRWQTITEMEITQESISMLEPYCSEFLIHAADVEGLQQGVDEELVSKLAEWCSIPVTYAGGARHLQDLEKVHVTSGGKVDLTIGSALDIFGGSGVTFDECIGWNKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBW9</accession>
    <name>B8MBW9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Adenylate kinase isoenzyme 6 homolog</fullName>
            <shortName evidence="10">AK6</shortName>
            <ecNumber evidence="10">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Dual activity adenylate kinase/ATPase</fullName>
            <shortName evidence="10">AK/ATPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_121580</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="10"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482407.1">
        <property type="nucleotide sequence ID" value="XM_002482362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBW9"/>
    <dbReference type="FunCoup" id="B8MBW9">
        <property type="interactions" value="824"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MBW9"/>
    <dbReference type="GeneID" id="8100746"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_121580"/>
    <dbReference type="eggNOG" id="KOG3347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079096_3_1_1"/>
    <dbReference type="InParanoid" id="B8MBW9"/>
    <dbReference type="OMA" id="QCEIFGT"/>
    <dbReference type="OrthoDB" id="10251185at2759"/>
    <dbReference type="PhylomeDB" id="B8MBW9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000372">
        <property type="entry name" value="Adenylate kinase isoenzyme 6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="10">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="10">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED18415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="179" mass="20232" checksum="1A798AE6A11F22F0" modified="2009-03-03" version="1">MRTAPNIIITGTPGVGKTIHSEQVAQDTGLQHLSINDIAKQRDCYDGYDEERQSWIIDEDKLLDAIEDDVTKGGYIIDWHACDLFPKSWIDLVVVLRCPSTAVYYDRLSSRGYPESKVDENMDAEIFGLLLEEAKEAYDEEIVIELTSENSDEIESNCARISAWVEAWKKSHSEEATDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MC82</accession>
    <name>B8MC82_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_122600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="EQ962655">
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</entry>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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                <person name="Fedorova-Abrams N.D."/>
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            <dbReference type="PubMed" id="25676766"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCM6</accession>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
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        <location>
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            <end position="491"/>
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    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="437"/>
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        <ligand>
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        <ligandPart>
            <name>Fe</name>
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        <source>
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    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED18842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="491" mass="55778" checksum="2C3BB4E2119AC49D" modified="2009-03-03" version="1">MALLDAVAHHTLVLACFITPCKTYPHKDPILGLDLFIENFRLLNKGGFLDKLSERYYRQNAWTYTQLLFREKVINTADPENIKAILATQFTDFQHSPRRKAAFYPTFGHGIFTTDGAEWEFSRALLRPSFVRSQVGDLDIFEAHISHLINKIPRDGSIVDIQQLFFALTMDTATQFLFGQSANVLVEGEPSARGEKFAEAYDYVTEIVGIQAKLGQIVAKIPNKRYTDSIKYIHEYVEMYVQKAVDFAKFGHSRSVHDAEANGRESHEKYVFLEELAKTGVDKKKIRDELLNVLFAGRDTTAGLLSFTFYILARRPDVFEKLRAEVMTLGSERPDFAQIKNMKYLQYTLKEVNRLYPIVPFNARAAVRDTTLPVGGGSDGKSPILVKAGQAINYQIYTMHRRKDLYGEDALEFKPERWEHIRPTWQYLPFNAGPRICIGQQFALTEASYTIIRLLQAFKSIRPREGEGPLTELLALTSSVRGGVNIGLTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCV4</accession>
    <name>B8MCV4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase M3A/M3B catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_113060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481472.1">
        <property type="nucleotide sequence ID" value="XM_002481427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCV4"/>
    <dbReference type="STRING" id="441959.B8MCV4"/>
    <dbReference type="GeneID" id="8105771"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_113060"/>
    <dbReference type="eggNOG" id="KOG2089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1344036_0_0_1"/>
    <dbReference type="InParanoid" id="B8MCV4"/>
    <dbReference type="OMA" id="WPNDELK"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="PhylomeDB" id="B8MCV4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="8">
        <location>
            <begin position="25"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED17480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="204" mass="23831" checksum="EFA67A49CB3E9A29" modified="2009-03-03" version="1">MVARNTRSPRKIKVHNVPWSPNSSGFTEALSQLLEYWCWVPECLRRLGCHYSYLSPENYKHWVTANFRKDTTRPLKEIPDEMVNNLLAAKQLNQGILTSRQVAFSKFDMQIHNPVSHDEIEAINFSELYNSLLQDMTGLQWPNDELKSGSGYATTSHYIWGQEANYYSYLYLQSTRILAADIWFTHFQSNPLSRNAGLRYREMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDJ0</accession>
    <name>B8MDJ0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_117380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481945.1">
        <property type="nucleotide sequence ID" value="XM_002481900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MDJ0"/>
    <dbReference type="STRING" id="441959.B8MDJ0"/>
    <dbReference type="GeneID" id="8105796"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_117380"/>
    <dbReference type="eggNOG" id="ENOG502SJW3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004835_2_2_1"/>
    <dbReference type="InParanoid" id="B8MDJ0"/>
    <dbReference type="OMA" id="RESLMYI"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="PhylomeDB" id="B8MDJ0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED17953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="639" mass="73491" checksum="FFDCCB6AAAE29EE2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDT6</accession>
    <name>B8MDT6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AN1 zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_120620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482307.1">
        <property type="nucleotide sequence ID" value="XM_002482262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MDT6"/>
    <dbReference type="FunCoup" id="B8MDT6">
        <property type="interactions" value="205"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MDT6"/>
    <dbReference type="GeneID" id="8100046"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_120620"/>
    <dbReference type="eggNOG" id="KOG3183">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052358_2_0_1"/>
    <dbReference type="InParanoid" id="B8MDT6"/>
    <dbReference type="OMA" id="RQYCLKH"/>
    <dbReference type="OrthoDB" id="431929at2759"/>
    <dbReference type="PhylomeDB" id="B8MDT6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057358">
        <property type="entry name" value="UBL_ZFAND1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF40">
        <property type="entry name" value="CDC48-ASSOCIATED UBIQUITIN-LIKE_ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25327">
        <property type="entry name" value="UBL_ZFAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="18"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED18315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="295" mass="32291" checksum="001C9CF8185A2809" modified="2009-03-03" version="1">MSSPQPTSFTEMADVDLESIGRNCQYEYCHQLDFLPFRCESCRGTFCSDHRTEAAHKCTHPGEWARRRRELNNKTTTSGGGGGGRTVKSTVYNSDQCSHPQCKTLHRLREGHDCANLIPLGARAGGKSTDNAATIRSMFSKLRGLGNNIQPPKAPKISLPASIQARRTTTGGNAITQLNEIKRTAKGEASIPTDKRIYLHVVGTTDKPTAETPPSGNYWFDSRWKVGRVLDDAARKLKVENLNNRVGGEEAKLRIFHVESGEFLEFSVAIGGEGSKVKSGHTIVLLRGAGVLLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEC2</accession>
    <name>B8MEC2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Maleylacetate reductase, putative</fullName>
            <ecNumber evidence="5">1.3.1.32</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_016280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.1.32" evidence="5"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483783.1">
        <property type="nucleotide sequence ID" value="XM_002483738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEC2"/>
    <dbReference type="STRING" id="441959.B8MEC2"/>
    <dbReference type="GeneID" id="8106401"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_016280"/>
    <dbReference type="eggNOG" id="KOG3857">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007207_0_1_1"/>
    <dbReference type="InParanoid" id="B8MEC2"/>
    <dbReference type="OMA" id="HAMSHQV"/>
    <dbReference type="OrthoDB" id="3360544at2759"/>
    <dbReference type="PhylomeDB" id="B8MEC2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018506">
        <property type="term" value="F:maleylacetate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08177">
        <property type="entry name" value="MAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034786">
        <property type="entry name" value="MAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF105">
        <property type="entry name" value="REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="3">
        <location>
            <begin position="10"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="4">
        <location>
            <begin position="165"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED16549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="357" mass="38056" checksum="CD8006FA122EA716" modified="2009-03-03" version="1">MDSFVYNANPGRVVFGSGTLKQLPEEVERLNLSAPLLLSTPQQVSQAEHLKQVLNGKIAGIFTEATMHTPTDVTEKALQYAKDIKADAVVSIGGGSTIGLGKAISIRTGLPHICIPTTYAGSEMTPILGETADGVKKTRTDPKILPGTVIYDVDLTMTLPAAMSATSGVNAIAHAVEALYARNTNPIINLLALEGTKALASSLPEIVENPSSPSARSQALYGAWLCGTCLGSVGMSIHHKLCHTLGGSFNLPHAETHTAVLPHAISYNAPRIPEAMKKLADALPESNGDAIHGLNVLLSKLKVKRGLKDFGMKEEDIDKAADIAVSNPYWNPREIERAPIRELIRRVWAGEPARADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEY8</accession>
    <name>B8MEY8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_023250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484505.1">
        <property type="nucleotide sequence ID" value="XM_002484460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEY8"/>
    <dbReference type="STRING" id="441959.B8MEY8"/>
    <dbReference type="GeneID" id="8109977"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_023250"/>
    <dbReference type="eggNOG" id="KOG0351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001104_0_1_1"/>
    <dbReference type="InParanoid" id="B8MEY8"/>
    <dbReference type="OMA" id="ICSERNQ"/>
    <dbReference type="OrthoDB" id="4353649at2759"/>
    <dbReference type="PhylomeDB" id="B8MEY8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022698">
        <property type="entry name" value="OrsD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12013">
        <property type="entry name" value="OrsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="387" mass="44568" checksum="5D6A6A4B40C4D261" modified="2009-03-03" version="1">MANPIAFQNLYFERLTDFPTTVVCRECRYSVWPSQIESHLQHAHRYLSSTLRKQLAEEVRSWPDIAINPIELDIPPTRIRAIPQLIGPLNGWQCQLSPELCWYYFAIIDHHDVEDERDRMDEANSISLPNAAIFWEQANAKFAEFEKKLVEKIAQGHVDEANPWLRRTGWLPYLKPFTFHALQAFIEAPEPPSEDENQSTAIPDTKTAEKCAAWAVWSAMGEVGRLSQLSVLHMGVFVRMEAICSERNQTRYQPLEAYQDANAVTDRVFRPGERRPWESRSIPSLPPSSGESRVETMAPQRVRPRGEEEMSDRSRDRLEGDADPEEVDPREDDDEEYDEENKEEEEVPPLTPIQQACLDFCIELLNQRIVRREYDSALICATAILGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFE5</accession>
    <name>B8MFE5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_017540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483913.1">
        <property type="nucleotide sequence ID" value="XM_002483868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFE5"/>
    <dbReference type="GeneID" id="8109011"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_017540"/>
    <dbReference type="eggNOG" id="ENOG502SAZV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_312139_0_0_1"/>
    <dbReference type="InParanoid" id="B8MFE5"/>
    <dbReference type="OMA" id="ILSNAWH"/>
    <dbReference type="OrthoDB" id="5343018at2759"/>
    <dbReference type="PhylomeDB" id="B8MFE5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="702"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="774"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="222"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="483"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="593"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="791"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED16679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="833" mass="93857" checksum="CB027F9894A7A47D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFK3</accession>
    <name>B8MFK3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">C2H2 conidiation transcription factor FlbC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_020500</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the sal C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484227.1">
        <property type="nucleotide sequence ID" value="XM_002484182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFK3"/>
    <dbReference type="STRING" id="441959.B8MFK3"/>
    <dbReference type="GeneID" id="8108860"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_020500"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036835_0_0_1"/>
    <dbReference type="InParanoid" id="B8MFK3"/>
    <dbReference type="OMA" id="PYACDVE"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="PhylomeDB" id="B8MFK3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000793">
        <property type="entry name" value="C2H2 finger domain protein FlbC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001278">
        <property type="entry name" value="C2H2 finger domain protein FlbC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051565">
        <property type="entry name" value="Sal_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233:SF84">
        <property type="entry name" value="FI23031P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233">
        <property type="entry name" value="SAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="313"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="25"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="234"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="25"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED16993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="350" mass="37702" checksum="990C48524EAF0F97" modified="2009-03-03" version="1">MTMVIENQNRQYGGMGGFDHAYQNNMHHTHSPQFTDPWTHTSSHSNPPVYPTTSIGASQMSMSPVKHEDVARPTAISLPYSSIPVSAPSLVAGSTYSSAGYGGSELLNMHHDIPRSTFDAAPSYTAATPINNFTPANYTSMGYAPGLQQDARRMSEARIPQPSASYSDAIDASRGMVALSQDLTPRGIYAPRSSRGSADSYGFPSTHSSVSSMSSASNYPYYSASVASVDSSVTDYSSTSDQYDGLPSRTLPRPNGLLGAAAPSGPQSMMGQFSSKMPSNAQKKHKCKVCDKRFTRPSSLQTHMYSHTGEKPYACDVEGCGRHFSVVSNLRRHKKVHKGEKETGSGEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFR2</accession>
    <name>B8MFR2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proline iminopeptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_021130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484286.1">
        <property type="nucleotide sequence ID" value="XM_002484241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFR2"/>
    <dbReference type="STRING" id="441959.B8MFR2"/>
    <dbReference type="ESTHER" id="talsn-b8mfr2">
        <property type="family name" value="Proline_iminopeptidase"/>
    </dbReference>
    <dbReference type="GeneID" id="8109370"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_021130"/>
    <dbReference type="eggNOG" id="KOG2382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_0_1"/>
    <dbReference type="InParanoid" id="B8MFR2"/>
    <dbReference type="OMA" id="EKYFDYT"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="PhylomeDB" id="B8MFR2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="23"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED17052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="297" mass="33625" checksum="AE73080980B1711C" modified="2009-03-03" version="1">MVEYITINGARLAYEISGPETAPLMITLHGGRGMGDHRSDYKIYSQLNDRLQVLSFDYRGHGQSSRTKPYTFEQLVDDIEGIRQQFLGAEEQVIICGGSFGGFLALHYAIKYASRVSRLILRGAAASHHRISAFSFQQHALLANLTTDEEDSIKSLEKRLHKAPNFSKEMLRDKVFGAYEDDEEFKLVYFAMMPLYKEVFDANAALKACRDTVCFAESHNELYSEKEKYFDYTKKLASITAKTLVIVGENDWICPPENSRIIAERIPGAELLVVSDANHSVHIEKPETVLGRIKEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGE4</accession>
    <name>B8MGE4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_013640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483498.1">
        <property type="nucleotide sequence ID" value="XM_002483453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGE4"/>
    <dbReference type="STRING" id="441959.B8MGE4"/>
    <dbReference type="GeneID" id="8099163"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_013640"/>
    <dbReference type="eggNOG" id="ENOG502RAXE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082799_0_0_1"/>
    <dbReference type="InParanoid" id="B8MGE4"/>
    <dbReference type="OMA" id="PIIMGES"/>
    <dbReference type="OrthoDB" id="4508018at2759"/>
    <dbReference type="PhylomeDB" id="B8MGE4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="279" mass="30797" checksum="95AF79B2B1DE2612" modified="2009-03-03" version="1">MSQFCGCISSSKPEPRTQVPAHSEAGFMSRPELQMQMHHHQPPHYDLVDNGYAPVVPLPRYTPRPMSIHEKTLENNSNFQRTHDQQQHRPDEKNRQDFEPEETLQSQSTGGSSSATVTPAIVDDASSAYSFPSSFGHTSTETRDTPPPPYSSCASSFYSRSRASSLRSHRRSGSLSNYSLNENQVQQGASEAAPSAAYTVPSAPPAAIIASPPMAHVHMSHRQHHHHHVHHPHPHDQYPRSINTNSAFTILSPINSTLPHLDSPPIIMGESVIYALLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGT9</accession>
    <name>B8MGT9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">homoisocitrate dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_014160</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(2R,3S)-homoisocitrate + NAD(+) = 2-oxoadipate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:11900"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57499"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.87" evidence="12"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483554.1">
        <property type="nucleotide sequence ID" value="XM_002483509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGT9"/>
    <dbReference type="FunCoup" id="B8MGT9">
        <property type="interactions" value="612"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MGT9"/>
    <dbReference type="GeneID" id="8099215"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_014160"/>
    <dbReference type="eggNOG" id="KOG0785">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_1_1"/>
    <dbReference type="InParanoid" id="B8MGT9"/>
    <dbReference type="OMA" id="DSFVMGE"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="PhylomeDB" id="B8MGT9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047046">
        <property type="term" value="F:homoisocitrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000012">
        <property type="entry name" value="Homoisocitrate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF48">
        <property type="entry name" value="HOMOISOCITRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="13">
        <location>
            <begin position="7"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED16320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="360" mass="38283" checksum="17FDCC9F5134681A" modified="2009-03-03" version="1">MAARTLRIGLIPGDGIGREVIPAGRRLLESLPTSLGLKFSFVDLDAGFDTFKKTGNALPDKTVDILKKECDGALFGAVSSPSTKVAGYSSPIVALRKRLDLYANVRPVKTTAGGSATGSPIDLVIVRENTEDLYVKEEKTTEGPEGKVAEAIKRISERASSRIATMAGEIALRRQKIRQVSPGTSHLSKPMVTITHKSNVLSQTDGLFRETARKALANPKYSTVEVEEQIVDSMVYKLFRQPGYYDVIVAPNLYGDILSDGAAALVGSLGLVPSANVGDGFAIGEPCHGSAPDIEGKGIANPIATLRSVALMLEFLGEEPAAAKIYAAVDANLDEGKYLSPDLGGKATTQEVLEDVLKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8MH93</accession>
    <name>B8MH93_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_021330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484306.1">
        <property type="nucleotide sequence ID" value="XM_002484261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MH93"/>
    <dbReference type="FunCoup" id="B8MH93">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MH93"/>
    <dbReference type="GeneID" id="8109390"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_021330"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="InParanoid" id="B8MH93"/>
    <dbReference type="OMA" id="AQVATNC"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="PhylomeDB" id="B8MH93"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF4">
        <property type="entry name" value="AMIDASE C550.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="75"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="227"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED17072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="559" mass="62127" checksum="A2763E29E0B4A093" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHC0</accession>
    <name>B8MHC0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol phosphate-mannose biosynthesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_021560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM2 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484333.1">
        <property type="nucleotide sequence ID" value="XM_002484288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHC0"/>
    <dbReference type="FunCoup" id="B8MHC0">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MHC0"/>
    <dbReference type="GeneID" id="8098422"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_021560"/>
    <dbReference type="eggNOG" id="KOG3488">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150144_2_1_1"/>
    <dbReference type="InParanoid" id="B8MHC0"/>
    <dbReference type="OMA" id="YTLWIIV"/>
    <dbReference type="OrthoDB" id="311279at2759"/>
    <dbReference type="PhylomeDB" id="B8MHC0"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180047">
        <property type="term" value="P:dolichol phosphate mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009914">
        <property type="entry name" value="DPM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039:SF11">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07297">
        <property type="entry name" value="DPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="5"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED17099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="90" mass="9786" checksum="DE9E34F6ACD895EB" modified="2009-03-03" version="1">MLGPLVGSAMLLVATAIFLYYTAWTLLMPFVDQGHPLHDLFPSRVWAIRIPVILTLLGSTVVGSFLGIMMIRSSRKKAAKAKAAASKKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHH3</accession>
    <name>B8MHH3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Choline transport protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_022080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484386.1">
        <property type="nucleotide sequence ID" value="XM_002484341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHH3"/>
    <dbReference type="STRING" id="441959.B8MHH3"/>
    <dbReference type="GeneID" id="8098474"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_022080"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_2_4_1"/>
    <dbReference type="InParanoid" id="B8MHH3"/>
    <dbReference type="OMA" id="KHYHGPR"/>
    <dbReference type="OrthoDB" id="4227284at2759"/>
    <dbReference type="PhylomeDB" id="B8MHH3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF24">
        <property type="entry name" value="TRANSPORT PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED17152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="519" mass="56316" checksum="F7A96312915C9C0C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHK9</accession>
    <name>B8MHK9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RING finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_011060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483224.1">
        <property type="nucleotide sequence ID" value="XM_002483179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHK9"/>
    <dbReference type="STRING" id="441959.B8MHK9"/>
    <dbReference type="GeneID" id="8109879"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_011060"/>
    <dbReference type="eggNOG" id="KOG4628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031409_1_0_1"/>
    <dbReference type="InParanoid" id="B8MHK9"/>
    <dbReference type="OMA" id="TKYKQWK"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="PhylomeDB" id="B8MHK9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16473">
        <property type="entry name" value="RING-H2_RNF103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000539">
        <property type="entry name" value="Ring finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765:SF434">
        <property type="entry name" value="GB|AAD18119.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="250"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED15990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="424" mass="45916" checksum="3A823F735202D08F" modified="2009-03-03" version="1">MSSTTSISTTSTAPPTSTSTSGGGGGGGGGGGGGPSSSPLLFFVALGFGVVFTNLWIIVGVKYCFRYNQRNRQLRNEETGEPIDLTAVPRPHRRRREKKLMSMEDVNERFPLMKYKAWRSSRADRGLPSEGGIAAPTNRPETPKAGESEQNHPDNSSVTAKHIEAYAPTKDHERTDSVVSEPSSPVTQQQISVISDSKEITSTETQPRAADADVISDVHPPDEEDLHDDHDDPIQGAVPAELLPSPGDSCAICLDTIEDDDDVRGLTCGHAFHASCLDPWLTSRRACCPLCKADYYVPKPRPEGQEAVTENARPGGRRTTGRTAAALRPPQAAFIINPFRTRTYFFTRSTVAVPENSDPRSARGSRSEIQPSSNVPPSERNGVRRTAAWVPRLNFWRASNRQSSSQNAGVRTPGQLEAGTTPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MI36</accession>
    <name>B8MI36_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pfs, NACHT and Ankyrin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_022520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484432.1">
        <property type="nucleotide sequence ID" value="XM_002484387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MI36"/>
    <dbReference type="STRING" id="441959.B8MI36"/>
    <dbReference type="GeneID" id="8107089"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_022520"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_2_1"/>
    <dbReference type="InParanoid" id="B8MI36"/>
    <dbReference type="OMA" id="AVVYVYC"/>
    <dbReference type="OrthoDB" id="4221929at2759"/>
    <dbReference type="PhylomeDB" id="B8MI36"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="322"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="774"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="808"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED17198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="843" mass="94756" checksum="D05C4AB038F86A70" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8MI75</accession>
    <name>B8MI75_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_040390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484512.1">
        <property type="nucleotide sequence ID" value="XM_002484467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MI75"/>
    <dbReference type="STRING" id="441959.B8MI75"/>
    <dbReference type="GeneID" id="8109995"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_040390"/>
    <dbReference type="eggNOG" id="ENOG502SC56">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_30_1_1"/>
    <dbReference type="InParanoid" id="B8MI75"/>
    <dbReference type="OrthoDB" id="4226558at2759"/>
    <dbReference type="PhylomeDB" id="B8MI75"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="13"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="319" mass="36361" checksum="7A079F3918F95BDD" modified="2009-03-03" version="1">MVWKTSLVQTPWQEPPRVVVDDGYQGYIGAAMVIPALGKQKIECIGTEDTSTVYAAEACGIKFALQIVLWLAEESVRLIVRKPVIFSDSQAVLQTLQNPRMVSGQVYIRDCVELLKECIEEGINVEIRWIPGHEGVPGNETADRAAKRAAFVGARHQVVPRDIKNWTMLAAAAKRRVCQSAKNAWERSWDKQKAGKPTKKLVTKPSWQTLAYWNYLRKATSSILIQLRTERVGLAHYLWRINRHDRLYCECGLSGHTVRHILMECPIYIDEWNLMWSRIKGFRRTTDLQALLTEKAAAVAVAQFIMDTRVLDQFRQADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIC1</accession>
    <name>B8MIC1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_040840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484558.1">
        <property type="nucleotide sequence ID" value="XM_002484513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIC1"/>
    <dbReference type="STRING" id="441959.B8MIC1"/>
    <dbReference type="GeneID" id="8099892"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_040840"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_837228_0_0_1"/>
    <dbReference type="InParanoid" id="B8MIC1"/>
    <dbReference type="OMA" id="INRELMC"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="PhylomeDB" id="B8MIC1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF1">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED14605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="332" mass="36602" checksum="2A09C7C44148A0AF" modified="2009-03-03" version="1">MSETGETQGEQIIRYIELSLELLYDLGGITETEQAWVNENAQFYSVVDGKISQSSSNWHRGNTAESNTRCSIFSTFVNGGGWQTQALSFFVGMPGLGFALFVNGVLGFVMVTCTMYVIGDLDTVLTAIAAGESPVLLIFQQAVRSQTGTVLMYVIILIMAGACMIGCFATASRMLWSFARDHGVPFSGWLSKLSRESVPLRSLAVNCLIAMLLSLILLGSSIGFSDLVNLTVACLYSSYICPANPDPPIHPSSLHWGPWKIPEPFGLLNNIFACSYLVLVFFWSFWPTVKDVKASTMNYNVLIYGVIVVFSMSWYFVRARHYYKGPLVETGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIW5</accession>
    <name>B8MIW5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_050650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485580.1">
        <property type="nucleotide sequence ID" value="XM_002485535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIW5"/>
    <dbReference type="STRING" id="441959.B8MIW5"/>
    <dbReference type="GeneID" id="8109107"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_050650"/>
    <dbReference type="HOGENOM" id="CLU_1035042_0_0_1"/>
    <dbReference type="InParanoid" id="B8MIW5"/>
    <dbReference type="PhylomeDB" id="B8MIW5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="269" mass="29220" checksum="DB7D333FE2EFE147" modified="2009-03-03" version="1">MPERRKVRNEAIKYERQAKAQMGLKSLTSRSNKKRGYDREKGSLSPLICGWSDTAPSSRQSSFSPSHHPTTGGKTISLEYYNRLKRSRVAEEDGDTDDEDGQDGDEDIGSNSEEAEQKTYGGKTIKQGDASQVSQYDVKNVLWVVKEKTSLAETKSSDESDDTESSSNTDSEVENGDEKGNRHGSAEARIGIEDNSGNAMKGAKEMKKNLSQSISDTDSEVENDNEDVVSSGNAPTEDGNEDGNGDEHHDEKPDGSGNAETGKDGGKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJ02</accession>
    <name>B8MJ02_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_051020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485617.1">
        <property type="nucleotide sequence ID" value="XM_002485572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJ02"/>
    <dbReference type="STRING" id="441959.B8MJ02"/>
    <dbReference type="GeneID" id="8109144"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_051020"/>
    <dbReference type="eggNOG" id="ENOG502SKA3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016972_1_1_1"/>
    <dbReference type="InParanoid" id="B8MJ02"/>
    <dbReference type="OMA" id="IGNQVYM"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="PhylomeDB" id="B8MJ02"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877777" description="GH16 domain-containing protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED15664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="33661" checksum="368CF331808397E3" modified="2009-03-03" version="1">MKGVTLVAAACPVILGTGVAAYNLQWDVNSSNFLDYFVFDTETDPTKGFVNYVDQSTASNDGLYKTNNNQIHLGVDSTTMLDSSATGRNSVRVYSQDTFSSGILITDFAHLPVSVCGIWPAYWTINNQANPYGEIDILEAYDDVAGAYVSLHTGNTCTLSNSGFTGTDVRTDCTLSNGGGCGVQSTSNQFGAGFNAAGGGVWALSLEDSLQLWVFTRDEIPADITSGNPDPSSWDTPLFKFDSNNGCDVASNFIDQTVIFNLDFCGDNGAGGQEWSDWTDCASSTGQSTCNAYVAANPSAYSETYFSINSIKLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJ12</accession>
    <name>B8MJ12_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS transporter Liz1/Seo1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_051120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485627.1">
        <property type="nucleotide sequence ID" value="XM_002485582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJ12"/>
    <dbReference type="FunCoup" id="B8MJ12">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="GeneID" id="8106314"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_051120"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_4_2_1"/>
    <dbReference type="InParanoid" id="B8MJ12"/>
    <dbReference type="OMA" id="SWHIWAL"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="PhylomeDB" id="B8MJ12"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000386">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="54"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED15674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="471" mass="53966" checksum="0BEB45778678F1CC" modified="2009-03-03" version="1">MTGAVGFENERISSELSDTVVQKETKRKWTSYVWDTLDKSPEERRLLFKLDTALLTFASLGYFIKYLDQINLNNAFVSGMQEDLGLYGNQLNYMTTCWTVGYVIGQIPSNMALTRIPPRYWIPTAEVIWSVLTMGLSRASSARQIYVMRFFIGLAESTFYPGMQYIIGSWYRKDELAKRSCIFHTSSGLGSMISGYLMAAVYHLGGRGGFKGWQWLFIIDGVISLPVALVGFFILPDVPEISNPWYLTKKEVAIAQRRMELEGREPRQPYTKAKFKKIFSSWHIYFLTVLYISFNNCNGGQPVLAQWLKHSKDPKYTIPQINAYATTPYAVQVITTLIYAWTSDTIFKGRRWPPILFGAISNIVCGASLLAWDIPRGWKWFCYIYSGAGYGLSGLCMAWAHEICTEDNEERALTVGSMNEMAYVFQAWLPLIVWQQVDAPKYHKGWITMITMSCILITTTFIVRFLHKREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJ75</accession>
    <name>B8MJ75_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_041420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484617.1">
        <property type="nucleotide sequence ID" value="XM_002484572.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MJ75"/>
    <dbReference type="GeneID" id="8109727"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_041420"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001613_8_1_1"/>
    <dbReference type="InParanoid" id="B8MJ75"/>
    <dbReference type="OMA" id="IKAGPTF"/>
    <dbReference type="OrthoDB" id="4369146at2759"/>
    <dbReference type="PhylomeDB" id="B8MJ75"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="5">
        <location>
            <begin position="431"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="4">
        <location>
            <begin position="613"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="1265"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1172"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1776"/>
            <end position="1799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED14664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1799" mass="205736" checksum="89DBCE5623987B65" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJ82</accession>
    <name>B8MJ82_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_041490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484624.1">
        <property type="nucleotide sequence ID" value="XM_002484579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJ82"/>
    <dbReference type="STRING" id="441959.B8MJ82"/>
    <dbReference type="GeneID" id="8109734"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_041490"/>
    <dbReference type="eggNOG" id="ENOG502SRKF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_950095_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJ82"/>
    <dbReference type="OMA" id="PTDWSSC"/>
    <dbReference type="OrthoDB" id="4770059at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED14671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="287" mass="30406" checksum="02442607D076FE12" modified="2009-03-03" version="1">MAVPTTITTSTTSAIRALTTTFTPAVSCLTDLYLYHVVSGGTVWDYRQLGPSPTSDCYPPNFTPTSSAYYSPGVCPTLYSIACSNVVSIGTVTETRATCCPSCQTFTDGWPWYSTELCTYAATGTSTFLLTDTSTISTSTGAPNFNAYGIQIRWQESDTSTPNAASATTTASSPLSTSPSPVSTSTPTPTSSSLSTGAKAGIGIGAGLGALLILAGVIFFGLRHRRNRAAKRQESVNMHFASDQSQQQQQYYVEAAAGDVRGKQPYHELSAQSREKAPVELSSESWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJJ1</accession>
    <name>B8MJJ1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_046450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485144.1">
        <property type="nucleotide sequence ID" value="XM_002485099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJJ1"/>
    <dbReference type="GeneID" id="8099556"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_046450"/>
    <dbReference type="HOGENOM" id="CLU_832031_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJJ1"/>
    <dbReference type="OrthoDB" id="10377674at2759"/>
    <dbReference type="PhylomeDB" id="B8MJJ1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="334" mass="38019" checksum="6DA0DB016B23F7EF" modified="2009-03-03" version="1">MTSLSSESNKSRYSDALESHILDVSSSNSSEIIVSDNYSEEPPFSTFSSSQASLNDDSNDTSRTIPDSQESRNNTNPEDEPISITYKNHILVQLSKDLSRLPAENFNRLQQVQETSSFWIKLFHHLSTLDSQTPPLKSREWAEYTVESSRVLFQAGLSTKKIVSILNHTIRYIANCILNTDNKETIFFENGLNVFYEPECCGIPDEMKVKYMETLEHLRDLVVRGGNGVIAQPEDEDSDDSVVSAASTVSVMPSIELGERIFQSIELQENSHSRVKGIQGRQKKNRGHLRKIGRFTKGIVKMQNREKMKKRLKKNRKARRRSHKNKHRVARGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B8MK31</accession>
    <name>B8MK31_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_043230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484801.1">
        <property type="nucleotide sequence ID" value="XM_002484756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MK31"/>
    <dbReference type="GeneID" id="8104965"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_043230"/>
    <dbReference type="eggNOG" id="ENOG502REGC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1661968_0_0_1"/>
    <dbReference type="InParanoid" id="B8MK31"/>
    <dbReference type="OrthoDB" id="4509841at2759"/>
    <dbReference type="PhylomeDB" id="B8MK31"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED14848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="159" mass="17738" checksum="F13932B8B90E3C18" modified="2009-03-03" version="1">MAGLQTSTIRDHAIQLEAVIRALKEYQVKPVGKNCTPNWNMIEPLLESFIIYLQKTQDLPAISELTAAVHAMARAQQILSKDVTEIKKILTAPIRKSSTPSYGQVLKDPYIVKSTAQTCLSMGHQKILVEPYPTDIETQAQRATAEEIKQKINNALTNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKP2</accession>
    <name>B8MKP2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_043620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484844.1">
        <property type="nucleotide sequence ID" value="XM_002484799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKP2"/>
    <dbReference type="GeneID" id="8097870"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_043620"/>
    <dbReference type="HOGENOM" id="CLU_900729_0_0_1"/>
    <dbReference type="InParanoid" id="B8MKP2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED14891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="309" mass="34107" checksum="631C0BECACD0FDB5" modified="2009-03-03" version="1">MTPRMTLMTSRFASSSRVTGPLLEASRAVSIPGDIFTYEDVKTYSGAPIFLEIQVGDTTYRRPATLGGLLDVGGSIYGLMVAHAASKDYLHDLGSSGKPMSYVHYDDKYEIPEDREDLDLKQPLSDAATGSDTASTRGRLHDVQEWLSSSRMVWPRLNPSFDVSRDGTGHSPRRLGSIRHISSNFDRDLFDWAIVELDTSSFAARQVNRLIYSATGWLEIPISSKLALQPGPRSAIVAATGSSGYVKGYLFSTPVLFQMEPGRSPLQAREVVFEKELKLGFWDVAMRVIGRLMSFDMFMAIAGIFLTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKR7</accession>
    <name>B8MKR7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Mitochondrial escape protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_043860</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the YME2 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484869.1">
        <property type="nucleotide sequence ID" value="XM_002484824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKR7"/>
    <dbReference type="FunCoup" id="B8MKR7">
        <property type="interactions" value="116"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MKR7"/>
    <dbReference type="GeneID" id="8097894"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_043860"/>
    <dbReference type="eggNOG" id="ENOG502QS0P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007861_1_0_1"/>
    <dbReference type="InParanoid" id="B8MKR7"/>
    <dbReference type="OMA" id="FQFFRPY"/>
    <dbReference type="OrthoDB" id="10267654at2759"/>
    <dbReference type="PhylomeDB" id="B8MKR7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12433">
        <property type="entry name" value="RRM_Yme2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018850">
        <property type="entry name" value="Mt_escape_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039627">
        <property type="entry name" value="Yme2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034260">
        <property type="entry name" value="Yme2_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198:SF2">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10443">
        <property type="entry name" value="RNA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="207"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="618"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED14916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="863" mass="98076" checksum="F793EA608FA41304" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8ML51</accession>
    <name>B8ML51_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short chain oxidoreductase (CsgA), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_049070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485420.1">
        <property type="nucleotide sequence ID" value="XM_002485375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ML51"/>
    <dbReference type="GeneID" id="8100623"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_049070"/>
    <dbReference type="eggNOG" id="KOG1611">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_1_1"/>
    <dbReference type="InParanoid" id="B8ML51"/>
    <dbReference type="OMA" id="FWASIEQ"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="PhylomeDB" id="B8ML51"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF36">
        <property type="entry name" value="CHAIN OXIDOREDUCTASE (CSGA), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="233" mass="24773" checksum="C7E7D391B04EA2A1" modified="2009-03-03" version="1">MASVLITGTSRGLGLALVEHILTLPSTIIGTIYATTRASSAPEALSELINSSNGRVHHVQLDVTDASSVAAAVHNVNQLSSGRGIDILINNAGRLGENSGKASAMTAADLETTFATNVMGVHRVTAAFLPLLREENSSSVPCTAYKISKAALSMLTVQYAAELASERFTVFEISPGWLQTDLGGEHAHLRPDVGAREVVRIVLEAKPERDNGVFRDICVEGFEGFYTGENPPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8MM90</accession>
    <name>B8MM90_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">hAT-like transposase RNase-H fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_098590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485840.1">
        <property type="nucleotide sequence ID" value="XM_002485795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MM90"/>
    <dbReference type="GeneID" id="8099687"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_098590"/>
    <dbReference type="HOGENOM" id="CLU_009123_4_0_1"/>
    <dbReference type="InParanoid" id="B8MM90"/>
    <dbReference type="OrthoDB" id="2976890at2759"/>
    <dbReference type="PhylomeDB" id="B8MM90"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23272">
        <property type="entry name" value="BED FINGER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED13602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="21247" checksum="A8783F8CC721A4E6" modified="2009-03-03" version="1">MNLSNKFIKYDVDTRWNSTFRMLSDALKSRTQLEKFIHYEIDFPPFSQKDWTRLSQIHTVLSKFNEFTLFILERKPQISLIVPIYYELYDLLHDAAERKEDFADIEEDVASAVRESIKKYMKYYTLMDISNTYYTALILDPRVKGDLLLYELDNEETGRKILQVLHGNLHENYPDTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MM98</accession>
    <name>B8MM98_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_099070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485890.1">
        <property type="nucleotide sequence ID" value="XM_002485845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MM98"/>
    <dbReference type="STRING" id="441959.B8MM98"/>
    <dbReference type="GeneID" id="8103985"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_099070"/>
    <dbReference type="eggNOG" id="KOG1290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_880473_0_0_1"/>
    <dbReference type="InParanoid" id="B8MM98"/>
    <dbReference type="OMA" id="GEHLFGD"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="PhylomeDB" id="B8MM98"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="98"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED13652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="316" mass="36156" checksum="931E795C332C9D0E" modified="2009-03-03" version="1">MDQWRWKNFTKPVLTEVSWDSRVFPCPSISSSSPYLAQSQLHFITTTEQVEWDSNRIYFKRLCLSLKEHSTVAHIIPTEAPIEEETYHVTTQRTIIRYEVAKKLGYGASSTSWLCRDLQSPSSVDSEGVLTSSKSNNYVVLKVSTSLPGYPTATDRESRVYEHLAKVDSSHFGRSLIRELYDSFDHQGPGGTHRCLVLQPVNMTLLEMMRMDPRPFDLPLVKMNLKTDNLMPSLEDRSMLANFAATEYENPSPRKLIHQSRIIYTSQKFCRPIGGRNYGLLVICDFGDARISKKQESGPFVQPHIYRAPEVIFEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMJ0</accession>
    <name>B8MMJ0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_099920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485982.1">
        <property type="nucleotide sequence ID" value="XM_002485937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMJ0"/>
    <dbReference type="GeneID" id="8105435"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_099920"/>
    <dbReference type="HOGENOM" id="CLU_1541134_0_0_1"/>
    <dbReference type="InParanoid" id="B8MMJ0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="119"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="174" mass="19838" checksum="E54778E47B43F727" modified="2009-03-03" version="1">MRRLSAGDYWLESTWLVPERTDALFTLPASKNEIHVTTDPKLHVQYQLGWKYRIIARLEPLQFNIQRDHAGGQTKIIDGMETNEKETCWRHGALSTQIKSQMDQVHDFLKEQERRSDELSEIKGEIAQFLNVLQKLKSAANDANQLNATNDEILDTQIGANLSGRDGMEESSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMX3</accession>
    <name>B8MMX3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_101620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486160.1">
        <property type="nucleotide sequence ID" value="XM_002486115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMX3"/>
    <dbReference type="STRING" id="441959.B8MMX3"/>
    <dbReference type="GeneID" id="8101850"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_101620"/>
    <dbReference type="eggNOG" id="ENOG502S1E7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1355455_0_0_1"/>
    <dbReference type="InParanoid" id="B8MMX3"/>
    <dbReference type="OrthoDB" id="4215483at2759"/>
    <dbReference type="PhylomeDB" id="B8MMX3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED13922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="22784" checksum="98036AAC6414120A" modified="2009-03-03" version="1">MSPHFAPWHPVLFGLTAQYDRSTRSTVMGDMNYRIEFLFEDGNLRTHIIRSEVAMLQFLSKTEVPFAKVFDYCLNEGNPIGVGLILMEKLAGQSLPWSPLSGAEDENHGSASRYILNCSGFVRFDGRFDDGRFYLRHADNKGDHILVDDEFYITGVLDWEWAHPDVKSSAFNSPVMLLPVADLHNGSNQLGEQGLDFAHISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMZ3</accession>
    <name>B8MMZ3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_101780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486180.1">
        <property type="nucleotide sequence ID" value="XM_002486135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMZ3"/>
    <dbReference type="GeneID" id="8099223"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_101780"/>
    <dbReference type="HOGENOM" id="CLU_000680_26_1_1"/>
    <dbReference type="InParanoid" id="B8MMZ3"/>
    <dbReference type="OrthoDB" id="5080849at2759"/>
    <dbReference type="PhylomeDB" id="B8MMZ3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED13942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="16495" checksum="B59C116880FC473D" modified="2009-03-03" version="1">MGSRWTTAAGSSTQPLHVEVNYLTTAAIVKSIPDNDIIIYSDGSKLENGQTGGGFVSFQAGSQFLRGSIPLRPNKEVFDAEAEAALAGLEAAMAHSTAQHAPNLWICLDNLEVTIQLLSSSIGFSQTVFKSFNILADTWLSRRRLLQIEGRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNH7</accession>
    <name>B8MNH7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Anterior fat body protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_102930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486304.1">
        <property type="nucleotide sequence ID" value="XM_002486259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNH7"/>
    <dbReference type="FunCoup" id="B8MNH7">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MNH7"/>
    <dbReference type="GeneID" id="8102912"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_102930"/>
    <dbReference type="eggNOG" id="KOG4499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036110_3_0_1"/>
    <dbReference type="InParanoid" id="B8MNH7"/>
    <dbReference type="OMA" id="HLWICHY"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="PhylomeDB" id="B8MNH7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF47">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="4">
        <location>
            <begin position="23"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED14066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="324" mass="36343" checksum="B2B66D0CFE0298C1" modified="2009-03-03" version="1">MTGLQVHHGGKPFFHCPKGPMILGEAPIYRASDSTLHWVDCLAEPCELYILKVDPITGHALPNSLRILKLNDSVTVQFFRRDKPGSYIAAYYQGVCFIDEASGKIDIVKEIIPTEKRDELRFNDGGIDAKGRFWLAEIDKVAMSYGPNQLPQEYGRPKGKLWRYDPDGSLHEMLDGGVVCGNGLGWSPDNKTFYFHDSVAMVVYAFDFDLESGNISNKRLLIDRRDSFGEPDGMVVDTEGNLWIAMFDSNRVMVFSPSGVHLKDIKFTARNPACTTWGGKDWDIIFLASGKWRGKREIEGDEGGHMFKFKPGDARGQAKYEFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNQ2</accession>
    <name>B8MNQ2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RSC complex subunit (RSC1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_103620</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486379.1">
        <property type="nucleotide sequence ID" value="XM_002486334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNQ2"/>
    <dbReference type="FunCoup" id="B8MNQ2">
        <property type="interactions" value="320"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MNQ2"/>
    <dbReference type="GeneID" id="8103065"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_103620"/>
    <dbReference type="eggNOG" id="KOG1827">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007728_0_0_1"/>
    <dbReference type="InParanoid" id="B8MNQ2"/>
    <dbReference type="OMA" id="QKWINAC"/>
    <dbReference type="OrthoDB" id="1742084at2759"/>
    <dbReference type="PhylomeDB" id="B8MNQ2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04717">
        <property type="entry name" value="BAH_polybromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.490:FF:000015">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit RSC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000048">
        <property type="entry name" value="RSC complex subunit (RSC1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF21">
        <property type="entry name" value="CHROMATIN STRUCTURE-REMODELING COMPLEX SUBUNIT RSC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="97"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="295"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="11">
        <location>
            <begin position="400"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="195"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="551"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="692"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="202"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="593"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="608"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="699"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED14141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="938" mass="106464" checksum="EE0667969CD21318" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPE8</accession>
    <name>B8MPE8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Stress response RCI peptide, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_105960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486625.1">
        <property type="nucleotide sequence ID" value="XM_002486580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPE8"/>
    <dbReference type="FunCoup" id="B8MPE8">
        <property type="interactions" value="1217"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MPE8"/>
    <dbReference type="GeneID" id="8100455"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_105960"/>
    <dbReference type="eggNOG" id="KOG1773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107649_6_2_1"/>
    <dbReference type="InParanoid" id="B8MPE8"/>
    <dbReference type="OMA" id="VHAIWVI"/>
    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="PhylomeDB" id="B8MPE8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF42">
        <property type="entry name" value="UPF0057 MEMBRANE PROTEIN ZK632.10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01309">
        <property type="entry name" value="UPF0057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED14387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="57" mass="6235" checksum="FD624E834DA2B121" modified="2009-03-03" version="1">MPFTASDICKIIFAIILPPVGVFLERGCGADLLINICLTILGYIPGIIHALYIILKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPJ9</accession>
    <name>B8MPJ9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polyprenyl-diphosphate synthase, putative</fullName>
            <ecNumber evidence="4">5.5.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_106480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.5.1.13" evidence="4"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486676.1">
        <property type="nucleotide sequence ID" value="XM_002486631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPJ9"/>
    <dbReference type="STRING" id="441959.B8MPJ9"/>
    <dbReference type="GeneID" id="8103548"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_106480"/>
    <dbReference type="eggNOG" id="KOG0777">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013198_0_0_1"/>
    <dbReference type="InParanoid" id="B8MPJ9"/>
    <dbReference type="OrthoDB" id="2343925at2759"/>
    <dbReference type="PhylomeDB" id="B8MPJ9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009905">
        <property type="term" value="F:ent-copalyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED14438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="960" mass="107429" checksum="887244A921095BAD" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPP1</accession>
    <name>B8MPP1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitochondrial chaperone bcs1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_106900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486718.1">
        <property type="nucleotide sequence ID" value="XM_002486673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPP1"/>
    <dbReference type="STRING" id="441959.B8MPP1"/>
    <dbReference type="GeneID" id="8103590"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_106900"/>
    <dbReference type="eggNOG" id="KOG0743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010189_4_4_1"/>
    <dbReference type="InParanoid" id="B8MPP1"/>
    <dbReference type="OMA" id="PSHISIM"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="PhylomeDB" id="B8MPP1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="7">
        <location>
            <begin position="34"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="253"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED14480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="488" mass="55274" checksum="BF54592A104E3B0B" modified="2009-03-03" version="1">MVYSETNSTAGLPPGNSLAEMSLPDLSSYLPPIVMLGALAAYLGWKPPKPRTILKNWLMSRIEVRWTDNIFEALEDFLAQEWVCKMSTHRLATTGSRLPWNKNEPNSHEEHVMGTTPPRTCSLPSLTLTPANGNHWFIYEGRLILLEREEREDAWERSQSLHLMCFGWDGSILRKILHAARLRHAELDENKTAVYRAQSNNKSIAWTRASGQGIRELSTVIMDPDLQKKFIEDIDGYLQPETRRWHTERGIPYRRGYLFEGPPGTGKTSLCIAVAGLFKLKIYILNLNNIAEDDLNNLISSLPQQCILLLEDVDSQKITNSRTTEPDNSFTTFQRLSLSGLLNAIDGVIASEGRILIMTTNHKDKLDPALIRPGRVDMTISFEYPDFDSIKRLFLLMYAEYPVEEKKEQQQPASSQCQFCPRLQPSPPANIPGNNISQDELQALANTFAASFPEKEYSQARILGYLKKHSGKPKRAVNLIAELFGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQA7</accession>
    <name>B8MQA7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-1,6-mannosyltransferase subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_057450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487365.1">
        <property type="nucleotide sequence ID" value="XM_002487320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQA7"/>
    <dbReference type="FunCoup" id="B8MQA7">
        <property type="interactions" value="128"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MQA7"/>
    <dbReference type="GeneID" id="8108881"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_057450"/>
    <dbReference type="eggNOG" id="KOG4748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021434_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQA7"/>
    <dbReference type="OMA" id="GEMYHYR"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="PhylomeDB" id="B8MQA7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007114">
        <property type="term" value="P:cell budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000117">
        <property type="entry name" value="Glycosyltransferase family 34 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF5">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED13254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="468" mass="54890" checksum="C82D521D9498EFDC" modified="2009-03-03" version="1">MTLSRSPSPLPGGGWSSPGLTPGSGATSPRYPTTGHGSLSPGAISWASAKAKSDEVRSYPSFSTRNSGFFSRQKRKISASLPRFSLSRDFREQEKLGRGRSTGWRARDNTQKGRVVSFVGNLMHRRRFRLLLLLLVGFILYLNFWSRLVEAYRASAFGNGKKIVIITASNVEGGVMEWKGAREWAIERVSLWNKRKYAKKWGYELEIVNMVAKKRYAHEWRESWEKVDLIRDAMKKYPNAEWFWWLDLNTFIMEYSYSLENHIFKHLGEYTYRDINYYNPLNITHPLTDVYFDPISRSATGDDNPNSINLVLPQDCGGFNLGSFFIRRSDWTDRLLDIWWDPVLYEQKHMDWEHKEQDSLEYLYANQPWIRLGTAFVPQRRVNSFPPGACGDGTDLGIHYQEKHRDFLVNMAGCNWGRDCWAEIYGYRELSNWLNRTLWEKFKDSITDFFRRWRGVKTLYEEHHEWVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQV0</accession>
    <name>B8MQV0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_053030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486896.1">
        <property type="nucleotide sequence ID" value="XM_002486851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQV0"/>
    <dbReference type="STRING" id="441959.B8MQV0"/>
    <dbReference type="GeneID" id="8098252"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_053030"/>
    <dbReference type="eggNOG" id="ENOG502S2ZX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_4_1_1"/>
    <dbReference type="InParanoid" id="B8MQV0"/>
    <dbReference type="OMA" id="CDERQNG"/>
    <dbReference type="OrthoDB" id="5396311at2759"/>
    <dbReference type="PhylomeDB" id="B8MQV0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="60"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="383"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="460"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="491"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED12785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="533" mass="61396" checksum="1463F9461628EFD9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MR57</accession>
    <name>B8MR57_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF803 domain membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_054620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487063.1">
        <property type="nucleotide sequence ID" value="XM_002487018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MR57"/>
    <dbReference type="GeneID" id="8100400"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_054620"/>
    <dbReference type="eggNOG" id="KOG2922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012349_2_1_1"/>
    <dbReference type="InParanoid" id="B8MR57"/>
    <dbReference type="OMA" id="VMQIRYI"/>
    <dbReference type="OrthoDB" id="165382at2759"/>
    <dbReference type="PhylomeDB" id="B8MR57"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF65">
        <property type="entry name" value="MAGNESIUM TRANSPORTER NIPA9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="86"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="422"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="700"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="469"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="502"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="521"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="577"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="606"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="700"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED12952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="781" mass="85735" checksum="81660E149DD92091" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSV1</accession>
    <name>B8MSV1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_000680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED11994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487648.1">
        <property type="nucleotide sequence ID" value="XM_002487603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSV1"/>
    <dbReference type="STRING" id="441959.B8MSV1"/>
    <dbReference type="GeneID" id="8108691"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_000680"/>
    <dbReference type="HOGENOM" id="CLU_039748_0_0_1"/>
    <dbReference type="InParanoid" id="B8MSV1"/>
    <dbReference type="OMA" id="IFNAGCI"/>
    <dbReference type="OrthoDB" id="3759773at2759"/>
    <dbReference type="PhylomeDB" id="B8MSV1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="57348" checksum="108247AFA301EA1F" modified="2009-03-03" version="1">MSLPGILRLPTEILVSIFEFQDLQAKWKDGGSIPNIRLTCRRFCALSSHLLIRSVYVDITKTETVDRLQSIAADAGLSKGVREVYLRVHFYHPWVAASFENFAAIWEFGRIAWGFIRRLDQTVADDASHHGLEEQSADSDVDALSPDRIRPNLVLQRAYKLYKAGYESQDRIMRNGGFKSVLSKTLSEFKDLRTVTIYDRELGNNYGPERLIRVPQEDHAGQETALVSVFTRPVVWEDAQWIQPTEEIWQGVPVELLVEIPIAIGKAKGIVVDHLAIEVTAAPDYTRLPTNAETLSSLSAAMESMDIFQLGFQPCCNGAWGPWTVDVDDDAVEGRRAESHAKFAAELQALDKYLGAMLDCKSIEYANISLGEFWIGAGVDSIRHAPTSLGTSWFHKPARIRCLRLFQVPLTTRDLERFVTNAMVDDEYEAEIHLHEVYLCNGTWKQFLDTLRTARRDNIKIGFSSLLGGGLDEMDQEVYSLVWGRFDGDESMVQQYIRGRIERNPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUQ1</accession>
    <name>B8MUQ1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_108990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488474.1">
        <property type="nucleotide sequence ID" value="XM_002488429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUQ1"/>
    <dbReference type="STRING" id="441959.B8MUQ1"/>
    <dbReference type="GeneID" id="8103155"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_108990"/>
    <dbReference type="eggNOG" id="KOG0658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_781144_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUQ1"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="PhylomeDB" id="B8MUQ1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055530">
        <property type="entry name" value="DUF7104"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23397">
        <property type="entry name" value="DUF7104"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="355" mass="40720" checksum="2312FA62E2A8D0BD" modified="2009-03-03" version="1">MVAKLKKYLTVCSKRKHSSEIRITPDIVQAAATNEVTEEMVMRLLLDERGSKIQITPDIVQTAAKNEYSGEMIVGILESRRPGHFVLVFISATWLKMVFEHKCLLCGKKWMNYTDLTRHISRYGDNDQVQGKESRNAFPFLRLPPSKRNRGILYTPLVQGIIRDLTNPKNTVKRSTWVIAFRQLLQVLQWLHSHHLVHRDIKLVNIGIDLNPLHVSILDLGAVGKLDSHTGTVHYIAPEMESTDYNGKVDIWASAVGCEIFLGSHPWPLSVNPWRADKNPRLDEYKKHHRCFVQSLRQNAKSETTMPVLSLIADMLNWSPKARHSALEALEYQFFLDTLNQERQGNVKRRKLSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MV03</accession>
    <name>B8MV03_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reverse transcriptase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_110720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488649.1">
        <property type="nucleotide sequence ID" value="XM_002488604.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MV03"/>
    <dbReference type="GeneID" id="8101444"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_110720"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_23_0_1"/>
    <dbReference type="InParanoid" id="B8MV03"/>
    <dbReference type="OMA" id="CNEAHES"/>
    <dbReference type="OrthoDB" id="3561817at2759"/>
    <dbReference type="PhylomeDB" id="B8MV03"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="956"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="3">
        <location>
            <begin position="1444"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED11893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1747" mass="192260" checksum="159E2A927EEA63F9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTK1</accession>
    <name>B8LTK1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mannose-1-phosphate guanyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GDP-mannose pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">GTP-mannose-1-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_065350</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340466.1">
        <property type="nucleotide sequence ID" value="XM_002340425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTK1"/>
    <dbReference type="FunCoup" id="B8LTK1">
        <property type="interactions" value="1318"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LTK1"/>
    <dbReference type="GeneID" id="8102018"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_065350"/>
    <dbReference type="eggNOG" id="KOG1460">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_3_0_1"/>
    <dbReference type="InParanoid" id="B8LTK1"/>
    <dbReference type="OMA" id="MPVPNWW"/>
    <dbReference type="OrthoDB" id="285674at2759"/>
    <dbReference type="PhylomeDB" id="B8LTK1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06428">
        <property type="entry name" value="M1P_guanylylT_A_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="11">
        <location>
            <begin position="310"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED23079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="440" mass="48570" checksum="8D996F8769C23880" modified="2009-03-03" version="1">MLQVPLREQPNNNNMASTKAVILVGGPSRGTRFRPLSLDVPKPLFEVAGHPIISHSLKAVAKVPGLREVILVGYYDESVFRDFIKDASKEFPHLRIQYLREYTALGTAGGLYHFRDAILKNKPERFFVLNSDVCCSFPLGEMLKLFEEKDAEAVILGTRVSNEAATNFGCIVSDAHTKRVLHYVEKPESHISNLINCGVYLFATECIFPSIRSVIKRRATRPRLLSYPSSDNLDSSFIAEDDDAEKPEVLRLEQDILSDLADSNRFFVHETKDFWRQIKTAGSAVPANALYLQKAFQAQSEELTPPSAFIVPPVYIHPTAQVDPTAKLGPNVSVGPRAVIGAGARVKEAIILEDAEIKHDACVLYSIIGWGSRVGAWARVEGTPTPAGSHSTSIIKNGVKVQSITILGKECGVGDEVRVQNCVCLPYKELKRDVTNEVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTP8</accession>
    <name>B8LTP8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="3">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Nuclear thiol peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSTA_070500</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 18">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="3"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341027.1">
        <property type="nucleotide sequence ID" value="XM_002340986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTP8"/>
    <dbReference type="FunCoup" id="B8LTP8">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LTP8"/>
    <dbReference type="GeneID" id="8102649"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_070500"/>
    <dbReference type="eggNOG" id="KOG0855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_2_0_1"/>
    <dbReference type="InParanoid" id="B8LTP8"/>
    <dbReference type="OMA" id="CTNQVCL"/>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="PhylomeDB" id="B8LTP8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03017">
        <property type="entry name" value="PRX_BCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000157">
        <property type="entry name" value="DOT5p Nuclear thiol peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF23">
        <property type="entry name" value="PEROXIREDOXIN DOT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="51"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EED23640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="227" mass="24134" checksum="7A75C1579AC70F06" modified="2009-03-03" version="1">MVVELRKRKAPAAQPGPVKKKAATAKSTKKVPKAEKATEEVKSKDTTTSKAAVPKVGDVISLEGFGGELQTQDGESTALQSLIASSKAGVVLFTYPRASTPGCTKQACMFRDGYEHLTSTGLAIYGLSTDSPKANTTFKTKQNLPYPLLCDPNATLIGSLGLKKSPKGTVRGVCVIDKTGKVLLLEPGSPAGTVEAVEKIVRENSVKNGDSEDKKEDPKEREDEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTV0</accession>
    <name>B8LTV0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mitochondrial acetolactate synthase small subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_071760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341167.1">
        <property type="nucleotide sequence ID" value="XM_002341126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTV0"/>
    <dbReference type="FunCoup" id="B8LTV0">
        <property type="interactions" value="330"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LTV0"/>
    <dbReference type="GeneID" id="8100164"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_071760"/>
    <dbReference type="eggNOG" id="KOG2663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055003_0_0_1"/>
    <dbReference type="InParanoid" id="B8LTV0"/>
    <dbReference type="OMA" id="CARSGMM"/>
    <dbReference type="OrthoDB" id="2013116at2759"/>
    <dbReference type="PhylomeDB" id="B8LTV0"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000001">
        <property type="entry name" value="Acetolactate synthase, small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="entry name" value="ACT-like. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054480">
        <property type="entry name" value="AHAS_small-like_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053050">
        <property type="entry name" value="ALS_regulatory_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242:SF2">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22629">
        <property type="entry name" value="ACT_AHAS_ss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="6">
        <location>
            <begin position="96"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED23780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="325" mass="34993" checksum="83CD522039147BB7" modified="2009-03-03" version="1">MAFRRALAKPVAAAPAISASTTTSAAKSSATSFFARNGRRSTSSSTSALAYKAMHRRSPLKLPVSDNAPQWDAPAAVSSILYETPLPSTNPPKRHILNCLVQNEPGVLSRVSGILAARGFNIDSLVVCNTEVADLSRMTIVLRGLDGVVEQARRQLDDLVPVWAVLDYTEAPLVQRELLLAKISTLGPEAFEELLKHHREMTSDDAAGAENGEAGVTIEDSHFHPRNIPASQALRHKHEHLDAITRLTHQFGGKVLDISTNNCIVEVSAKPSRIDSFLKLVGPFGILESTRTGLMALTRSPLTEVTEEVEKEAADVVDASTLPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTW3</accession>
    <name>B8LTW3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">cAMP-mediated signaling protein Sok1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_071890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341180.1">
        <property type="nucleotide sequence ID" value="XM_002341139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTW3"/>
    <dbReference type="STRING" id="441959.B8LTW3"/>
    <dbReference type="GeneID" id="8103898"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_071890"/>
    <dbReference type="eggNOG" id="KOG1981">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016970_2_1_1"/>
    <dbReference type="InParanoid" id="B8LTW3"/>
    <dbReference type="OMA" id="LHWRVWS"/>
    <dbReference type="OrthoDB" id="276323at2759"/>
    <dbReference type="PhylomeDB" id="B8LTW3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010737">
        <property type="term" value="P:protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF11">
        <property type="entry name" value="LD23868P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED23793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="604" mass="69293" checksum="74EA7E19E6117EB6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8LU27</accession>
    <name>B8LU27_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine Rich Repeat domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_072500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
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            <taxon>Eurotiomycetidae</taxon>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="19"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="652"/>
        </location>
    </feature>
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        <location>
            <begin position="702"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="759"/>
            <end position="782"/>
        </location>
    </feature>
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        <location>
            <begin position="710"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="769"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED23857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="827" mass="91639" checksum="3E38058EB77504D5" modified="2009-03-03" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
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        <location>
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        <location>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED23700.1"/>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
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    <comment type="function">
        <text evidence="3">Involved in translation.</text>
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        <subcellularLocation>
            <location evidence="1 3">Cytoplasm</location>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="3">Belongs to the TMA20 family.</text>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
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        <location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED24032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="181" mass="19739" checksum="33C2A6EF0E101382" modified="2009-03-03" version="1">MFKKDFQAGSRSKVKSSVQRGLRSKLIETYPGFEPYIDEIMPKKASLEAVKLPDRVTLYTIDSNPLFYQPFDGPPIPHLKLIHAFPDVVPKIQIDRGAIRFVLSGAALMAPGLTSPGGRLPDKDNALNVGDVVAVSAEGKTEVCMVGPLKMGTEEMKEKGKGVVMDAGHYLGDGLWKLNLD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-10-14" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8LV47</accession>
    <accession>Q70Y21</accession>
    <name>FAEC_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Feruloyl esterase C</fullName>
            <ecNumber evidence="3">3.1.1.73</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Ferulic acid esterase C</fullName>
            <shortName>FAE</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">faeC</name>
        <name type="ORF">TSTA_065520</name>
    </gene>
    <organism>
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="J. Biotechnol." volume="108" first="227" last="241">
            <title>The feruloyl esterase system of Talaromyces stipitatus: production of three discrete feruloyl esterases, including a novel enzyme, TsFaeC, with a broad substrate specificity.</title>
            <authorList>
                <person name="Garcia-Conesa M.T."/>
                <person name="Crepin V.F."/>
                <person name="Goldson A.J."/>
                <person name="Williamson G."/>
                <person name="Cummings N.J."/>
                <person name="Connerton I.F."/>
                <person name="Faulds C.B."/>
                <person name="Kroon P.A."/>
            </authorList>
            <dbReference type="PubMed" id="15006424"/>
            <dbReference type="DOI" id="10.1016/j.jbiotec.2003.12.003"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>PROTEIN SEQUENCE OF 26-44; 322-341; 395-412; 476-487 AND 512-527</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <source>
            <strain>ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Involved in degradation of plant cell walls. Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans as well as the feruloyl-galactose and feruloyl-arabinose ester bonds in pectin (By similarity). Active against methyl esters of sinapate (MSA) and caffeate (MCA) (PubMed:15006424).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.73" evidence="3"/>
    <dbReference type="EMBL" id="AJ505939">
        <property type="protein sequence ID" value="CAD44531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340484.1">
        <property type="nucleotide sequence ID" value="XM_002340443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LV47"/>
    <dbReference type="SMR" id="B8LV47"/>
    <dbReference type="STRING" id="441959.B8LV47"/>
    <dbReference type="ESTHER" id="9euro-q70y21">
        <property type="family name" value="Tannase"/>
    </dbReference>
    <dbReference type="GeneID" id="8109464"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_065520"/>
    <dbReference type="eggNOG" id="ENOG502QPXZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014819_1_0_1"/>
    <dbReference type="InParanoid" id="B8LV47"/>
    <dbReference type="OMA" id="AWFPREY"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="PhylomeDB" id="B8LV47"/>
    <dbReference type="BRENDA" id="3.1.1.73">
        <property type="organism ID" value="4645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF15">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0106">Calcium</keyword>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0719">Serine esterase</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001370416" description="Feruloyl esterase C">
        <location>
            <begin position="26"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="2">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="31"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="66"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="190"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="O42807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q2UP89"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="15006424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="15006424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="530" mass="58020" checksum="ADE064D3BA5634D5" modified="2009-03-03" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVP1</accession>
    <name>B8LVP1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-channel protein CCH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TSTA_075430</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Voltage-gated, high-affinity calcium channel that functions together with MID1 to mediate calcium entry into cells. Required during conditions of environmental stress.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341558.1">
        <property type="nucleotide sequence ID" value="XM_002341517.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B8LVP1">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LVP1"/>
    <dbReference type="GeneID" id="8102305"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_075430"/>
    <dbReference type="eggNOG" id="KOG2301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000443_0_0_1"/>
    <dbReference type="InParanoid" id="B8LVP1"/>
    <dbReference type="OMA" id="TLFIAWN"/>
    <dbReference type="OrthoDB" id="416585at2759"/>
    <dbReference type="PhylomeDB" id="B8LVP1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000093">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000118">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000063">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000079">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000098">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="385"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="557"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="668"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="692"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="764"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="791"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="881"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="926"/>
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</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="Proteomes" id="UP000001745"/>
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</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
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            <taxon>Eurotiomycetidae</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
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        <property type="entry name" value="AB_hydrolase_fold"/>
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        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051340">
        <property type="entry name" value="Haloalkane_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42977:SF3">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42977">
        <property type="entry name" value="HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="29"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED24359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="480" mass="54049" checksum="7EED5B01DDDA93B6" modified="2009-03-03" version="1">MSTTLLNTLELPTSKTSIFYREAGDKSAPVILLLHGFPSSSHQFGNLIPILATKYRVSAPDLPGFGFTEVKTKISNIPFDNLATTILEFLDTLSIEKFVYIFDYGAPTGLRLALARPQGVQAIITQNGNAYEDGLGEFWDQIRELWNTNNDPKVRSKLASGLLSLEATKWQYEEGTQKSRVVAPESYILDYALMQRPGNSDIQIDLFWDYRTNLPLYPQFHEYFQKSQVPLLAAWGKNDQIFIAPGAEAFKRDLPNAEVHFLDAGHFAVETETVEIGSLILKFFGPQWNLNFINPGAKGDGIALLYPPVKGSIIRVFLDLSEITQAIELLPKRTCGPKILTMIGDSRAQVLHRLCSLPDETDRPSMVFHKRSCSTEKPGLLYRALLVSPLPQTTVLWNQLTRDVFECMNKLEEQEDSQPIAEILLWCSVIVGITAEGSNYQQWFISKAWSLRGYLRISSWVELKELLASFAWLDCASDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWD2</accession>
    <name>B8LWD2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tubulin-specific chaperone, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_076140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341630.1">
        <property type="nucleotide sequence ID" value="XM_002341589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWD2"/>
    <dbReference type="FunCoup" id="B8LWD2">
        <property type="interactions" value="642"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LWD2"/>
    <dbReference type="GeneID" id="8103947"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_076140"/>
    <dbReference type="eggNOG" id="KOG3207">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017716_3_1_1"/>
    <dbReference type="InParanoid" id="B8LWD2"/>
    <dbReference type="OMA" id="SEESHMF"/>
    <dbReference type="OrthoDB" id="5273213at2759"/>
    <dbReference type="PhylomeDB" id="B8LWD2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF9">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="7">
        <location>
            <begin position="24"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED24243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="619" mass="69694" checksum="6891C88A111C6C58" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWW9</accession>
    <name>B8LWW9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cell wall organization protein/glutathione transferase (Gto3), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_079570</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341989.1">
        <property type="nucleotide sequence ID" value="XM_002341948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWW9"/>
    <dbReference type="STRING" id="441959.B8LWW9"/>
    <dbReference type="GeneID" id="8105096"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_079570"/>
    <dbReference type="eggNOG" id="KOG2903">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_333747_0_0_1"/>
    <dbReference type="InParanoid" id="B8LWW9"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="PhylomeDB" id="B8LWW9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF1">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01148">
        <property type="entry name" value="Xi_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="9">
        <location>
            <begin position="673"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED24602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="856" mass="95002" checksum="B16DD8809E9C3220" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8LX93</accession>
    <name>B8LX93_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH64 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_062300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340130.1">
        <property type="nucleotide sequence ID" value="XM_002340089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LX93"/>
    <dbReference type="GeneID" id="8107594"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_062300"/>
    <dbReference type="eggNOG" id="ENOG502SJJ1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032886_2_0_1"/>
    <dbReference type="InParanoid" id="B8LX93"/>
    <dbReference type="OMA" id="ASLNWGF"/>
    <dbReference type="OrthoDB" id="5290283at2759"/>
    <dbReference type="PhylomeDB" id="B8LX93"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.50">
        <property type="entry name" value="Beta-1,3-glucanase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032477">
        <property type="entry name" value="Glyco_hydro_64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037398">
        <property type="entry name" value="Glyco_hydro_64_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042517">
        <property type="entry name" value="Glyco_hydro_64_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38165">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38165:SF1">
        <property type="entry name" value="GLUCANASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16483">
        <property type="entry name" value="Glyco_hydro_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52006">
        <property type="entry name" value="GH64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877275" description="GH64 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="GH64" evidence="2">
        <location>
            <begin position="19"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED22743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="377" mass="40521" checksum="3005E8D9027DFA5A" modified="2009-03-03" version="1">MIVPRMQPLIGFCFVTVVVARLSISIVNNLPGNTSTYAYVTAQDPDNRLVLLQTDSTWYHPEPSTLSSIPLKVSQSIAIPLAAEGASTTVTIPSDFSSGRIWVSINSLTFYAVLDNNGAATLIEPSVTDTTDLNSLVHWGFVELSYTAETGLFVNLSYVDFVGLALGISLESEDGSIQEALGIPAAAVTDICNRLRRQASSSGQPWDQLCVNDSNGGILRVLSPKSYISLHPSAFQDYYSEYVDEVWSTYSRRPLTVNSQTSAADIFGCSTGPFNIDTTTDNNIHVAIVPRLCAALHRATLLLKGGDFQPGLDPAFYYMTDPSNVYSNLVHDLELDGKGYAFPYDDVGPSGADQSGLIASQAPKSLIITVGGPSTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXA2</accession>
    <name>B8LXA2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_066330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340570.1">
        <property type="nucleotide sequence ID" value="XM_002340529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXA2"/>
    <dbReference type="STRING" id="441959.B8LXA2"/>
    <dbReference type="GeneID" id="8105104"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_066330"/>
    <dbReference type="eggNOG" id="ENOG502S0KD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004286_6_0_1"/>
    <dbReference type="InParanoid" id="B8LXA2"/>
    <dbReference type="OMA" id="MANAPAW"/>
    <dbReference type="OrthoDB" id="4226893at2759"/>
    <dbReference type="PhylomeDB" id="B8LXA2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022198">
        <property type="entry name" value="DUF3723"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12520">
        <property type="entry name" value="DUF3723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="863"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1092"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1096"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1132"/>
            <end position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1259" mass="142355" checksum="DB4ADFE921E35408" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXK2</accession>
    <name>B8LXK2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_078600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341890.1">
        <property type="nucleotide sequence ID" value="XM_002341849.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341891.1">
        <property type="nucleotide sequence ID" value="XM_002341850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXK2"/>
    <dbReference type="STRING" id="441959.B8LXK2"/>
    <dbReference type="GeneID" id="8101144"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_078600"/>
    <dbReference type="eggNOG" id="ENOG502SI2P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065434_0_1_1"/>
    <dbReference type="InParanoid" id="B8LXK2"/>
    <dbReference type="OMA" id="LYAYANW"/>
    <dbReference type="OrthoDB" id="5352400at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED24503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="325" mass="36608" checksum="B49B22604BE78FE4" modified="2009-03-03" version="1">MFIPRTYKHHYLALYLMIAEIPFILPILILTGIASHDTYTTKLWQDGANNGFNSAPNQIVYALTNGESYKVPIVWSSVLYNYDLVIGVLSTFIILTKVPIHVLRFFYPPISAFVHGALFILYVAAACFQAGSDTTDERHPQHGPPWYITKSCKVAYSPSNIGYCQQAKALFAMTVIAVVIYFAETVLAIMSCFVSQEEKEAWRRRQQEKREEKEAEDRALREYEEIINSPTFPPVAMPGAIYTPGPIASPYHQTHFFHSQGQYQSLNDPSPSSSSDLPFRNWGTPKTSSFANGGHVSVNISETGEQQQQQQDQPYFPPPPKKATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0A0</accession>
    <name>B8M0A0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1275 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_084280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478160.1">
        <property type="nucleotide sequence ID" value="XM_002478115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0A0"/>
    <dbReference type="STRING" id="441959.B8M0A0"/>
    <dbReference type="GeneID" id="8101521"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_084280"/>
    <dbReference type="eggNOG" id="ENOG502S0ZW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061825_0_0_1"/>
    <dbReference type="InParanoid" id="B8M0A0"/>
    <dbReference type="OMA" id="FQSAGGM"/>
    <dbReference type="OrthoDB" id="5288586at2759"/>
    <dbReference type="PhylomeDB" id="B8M0A0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF8">
        <property type="entry name" value="DUF1275 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G13060)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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</entry>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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            <dbReference type="PubMed" id="25676766"/>
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            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="EMBL" id="EED21287.1"/>
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            <dbReference type="Proteomes" id="UP000001745"/>
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    <sequence length="538" mass="58881" checksum="101DAB44502DBEE9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0K6</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="MFS_dom"/>
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    </dbReference>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED21303.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="4">DUF1365 domain protein</fullName>
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        <name evidence="2" type="ORF">TSTA_086860</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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    </organism>
    <reference evidence="3" key="1">
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
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    <dbReference type="AlphaFoldDB" id="B8M0S0"/>
    <dbReference type="GeneID" id="8110092"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_086860"/>
    <dbReference type="eggNOG" id="ENOG502RGVU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_455737_0_0_1"/>
    <dbReference type="InParanoid" id="B8M0S0"/>
    <dbReference type="OMA" id="FIASQAC"/>
    <dbReference type="OrthoDB" id="4226486at2759"/>
    <dbReference type="PhylomeDB" id="B8M0S0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010775">
        <property type="entry name" value="DUF1365"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33973">
        <property type="entry name" value="OS07G0153300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33973:SF4">
        <property type="entry name" value="OS07G0153300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07103">
        <property type="entry name" value="DUF1365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="599" mass="68337" checksum="D05FB36D944EDCF1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0W4</accession>
    <name>B8M0W4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_089830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478707.1">
        <property type="nucleotide sequence ID" value="XM_002478662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0W4"/>
    <dbReference type="GeneID" id="8108071"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_089830"/>
    <dbReference type="HOGENOM" id="CLU_2943399_0_0_1"/>
    <dbReference type="InParanoid" id="B8M0W4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED21744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="60" mass="7018" checksum="6AE5CFC56463321E" modified="2009-03-03" version="1">MESAKDEKLDKIEIDLISDTEEQYTIIDDEIGLDEIGEADEVRVSGRKRKSRDDDIFEYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1K1</accession>
    <name>B8M1K1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_093340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479051.1">
        <property type="nucleotide sequence ID" value="XM_002479006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1K1"/>
    <dbReference type="STRING" id="441959.B8M1K1"/>
    <dbReference type="GeneID" id="8102578"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_093340"/>
    <dbReference type="eggNOG" id="ENOG502RWEW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1705422_0_0_1"/>
    <dbReference type="InParanoid" id="B8M1K1"/>
    <dbReference type="OrthoDB" id="4225986at2759"/>
    <dbReference type="PhylomeDB" id="B8M1K1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED22088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="154" mass="17944" checksum="E6980FAF3A248466" modified="2009-03-03" version="1">MYPVYLHLCVLIKPLKEVKESRTGGVRPEMNAELDMTLPVIDILEGAKLRGEFLPGFDGARDVWREDIEIYAPGYLQMEAEGNEADYDHHISSIRMKHLRFVKVCIRNRRVQRWRGGVPVTFLKSFNCRFGIRKELQNLVQKSLEHGSRDKCRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1X9</accession>
    <name>B8M1X9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_085880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478320.1">
        <property type="nucleotide sequence ID" value="XM_002478275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1X9"/>
    <dbReference type="FunCoup" id="B8M1X9">
        <property type="interactions" value="1088"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M1X9"/>
    <dbReference type="GeneID" id="8104553"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_085880"/>
    <dbReference type="eggNOG" id="KOG1754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098428_1_1_1"/>
    <dbReference type="InParanoid" id="B8M1X9"/>
    <dbReference type="OMA" id="LPAKNFG"/>
    <dbReference type="OrthoDB" id="10250260at2759"/>
    <dbReference type="PhylomeDB" id="B8M1X9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000001">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047863">
        <property type="entry name" value="Ribosomal_uS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003115">
        <property type="entry name" value="PRK04034.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED21357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="130" mass="14781" checksum="B75B6B6626DDD1C3" modified="2009-03-03" version="1">MVRTSVLNDALNAMNNAEKAGKRQVLIRPSSKVIVKFLTVMQKHGYIGEFEEIDDHRSGKIVVQLNGRLNKTGVISPRYNVQLRDLEKWVVKLLPSRQFGYVVLTTSAGIMDHEEARRKHVAGKIIGFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8M234</accession>
    <name>B8M234_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_087340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478461.1">
        <property type="nucleotide sequence ID" value="XM_002478416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M234"/>
    <dbReference type="GeneID" id="8100863"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_087340"/>
    <dbReference type="eggNOG" id="ENOG502SVIN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136305_1_0_1"/>
    <dbReference type="InParanoid" id="B8M234"/>
    <dbReference type="OMA" id="THRITQP"/>
    <dbReference type="OrthoDB" id="3913483at2759"/>
    <dbReference type="PhylomeDB" id="B8M234"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="143" mass="15223" checksum="BC26A5B080E5B759" modified="2009-03-03" version="1">MSSSNFHTTTQDLRKPESRVSKAHGGQTPADSDISVMKSVLDSGTNKQEQIERARNNLPLPDQPPVASDWNSADQRTVNVGSGRFESSASTGAGSSALRDPATVDSSVRVDGEEYHKATEPGSSVGRQGQEGLDSLPKDARTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2M3</accession>
    <name>B8M2M3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isochorismatase family hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_091750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EED21934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002478852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2M3"/>
    <dbReference type="STRING" id="441959.B8M2M3"/>
    <dbReference type="GeneID" id="8098561"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_091750"/>
    <dbReference type="eggNOG" id="KOG4044">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066901_0_0_1"/>
    <dbReference type="InParanoid" id="B8M2M3"/>
    <dbReference type="OMA" id="HVCVFQT"/>
    <dbReference type="OrthoDB" id="269496at2759"/>
    <dbReference type="PhylomeDB" id="B8M2M3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050993">
        <property type="entry name" value="Isochorismatase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119:SF3">
        <property type="entry name" value="ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="41"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED21934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="235" mass="25961" checksum="0A95E857F2D40E33" modified="2009-03-03" version="1">MANLSARASRISGFLSKFEFAEENDRRLTILSSRKSGAIFREHIYEFPKVVSTTQKLLKASATLEVPVYITTQNKARLGDTVSELLSQITPDNGQPGNTVIANIDKTAFSMYTPDIVSQYHSATKNKSDKDPEQKLDAIIVGIETHICVTQTTLDLLEAGHRVYIVADAVSSVNSEERGIALNRLRDAGAIVTTSESLIFEMLRDAKSPGFKSINGLIKEYKEDTKNAVKILCKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2P9</accession>
    <name>B8M2P9_TALSN</name>
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        <recommendedName>
            <fullName evidence="3">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_092020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="441959.B8M2P9"/>
    <dbReference type="GeneID" id="8098587"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_092020"/>
    <dbReference type="HOGENOM" id="CLU_1476085_0_0_1"/>
    <dbReference type="InParanoid" id="B8M2P9"/>
    <dbReference type="OrthoDB" id="2976890at2759"/>
    <dbReference type="PhylomeDB" id="B8M2P9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED21960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="21014" checksum="BC70E76B5AA228B1" modified="2009-03-03" version="1">MAKYDNSCNILYITMLLDPRFKKFVLEHKLQDEAKGIITTMQEQLEIQYPIIYKTELTTTSEEPEPSAAFQNPHKTIVSEMMSKIKAKSQKSAEKSSDIARYLNSDVVKFDEKKRNLIHTWWRGHIDECPRMAAAAWTGYHLTHVDACLCAILELARSRRGVDINPRPHHLARAHMTSSRASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3B5</accession>
    <name>B8M3B5_TALSN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_095360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479250.1">
        <property type="nucleotide sequence ID" value="XM_002479205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3B5"/>
    <dbReference type="GeneID" id="8103863"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_095360"/>
    <dbReference type="HOGENOM" id="CLU_1897601_0_0_1"/>
    <dbReference type="InParanoid" id="B8M3B5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED22287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="134" mass="14834" checksum="03829994E305E1E3" modified="2009-03-03" version="1">MINHQPIRLQFIKTPVLIIPQVTLRLQHHIIKVHPPTATPALHRTDISHQASHNTGQVLRVATTSQAISKVIPHKGINKAIRHRDISKGILHRVTMHKIPIGDTVRQTEFAQGFAKVLISFGNGSGESALFFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3C7</accession>
    <name>B8M3C7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromosome segregation protein BIR1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_095480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479262.1">
        <property type="nucleotide sequence ID" value="XM_002479217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3C7"/>
    <dbReference type="STRING" id="441959.B8M3C7"/>
    <dbReference type="GeneID" id="8105859"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_095480"/>
    <dbReference type="eggNOG" id="KOG1101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010318_1_0_1"/>
    <dbReference type="InParanoid" id="B8M3C7"/>
    <dbReference type="OMA" id="DEHYNRS"/>
    <dbReference type="OrthoDB" id="2196114at2759"/>
    <dbReference type="PhylomeDB" id="B8M3C7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051190">
        <property type="entry name" value="Baculoviral_IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771:SF5">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="201"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="412"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="483"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="503"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="616"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="634"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="675"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="714"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="777"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="820"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="847"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED22299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="952" mass="106297" checksum="A9410C4A5E43EFAC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3M6</accession>
    <name>B8M3M6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_096470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479361.1">
        <property type="nucleotide sequence ID" value="XM_002479316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3M6"/>
    <dbReference type="STRING" id="441959.B8M3M6"/>
    <dbReference type="GeneID" id="8103490"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_096470"/>
    <dbReference type="HOGENOM" id="CLU_1367053_0_0_1"/>
    <dbReference type="InParanoid" id="B8M3M6"/>
    <dbReference type="OrthoDB" id="4223481at2759"/>
    <dbReference type="PhylomeDB" id="B8M3M6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="200" mass="21496" checksum="9D70320644898634" modified="2009-03-03" version="1">MTSEDWTKEEGEDKDDISSVTEGPSETASTVPESEGGVPLPVPSIFSATSMSRRQLTPMDHEKLAGGAWLEQEDAKSTAPPSEAESAAVTRAASMAAKYSGWNENAVEAEKKMAPPALTRAVPAKGSEPERRIKGWAKITSADPERSARILKMSDPTRFDKTKEDETENPSGRTIIGAKDRSRLHKQIRTGGAESASPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3P0</accession>
    <name>B8M3P0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_096610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479375.1">
        <property type="nucleotide sequence ID" value="XM_002479330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3P0"/>
    <dbReference type="GeneID" id="8103504"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_096610"/>
    <dbReference type="HOGENOM" id="CLU_1332715_0_0_1"/>
    <dbReference type="InParanoid" id="B8M3P0"/>
    <dbReference type="PhylomeDB" id="B8M3P0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED22412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="206" mass="23886" checksum="1136A6A5884F2D91" modified="2009-03-03" version="1">MKDQEIDHQNDKSRDLQSSLSNALKLNTLLFKIRDDELPMACCQLAHEVKCIELGVLRTADLFASHLFPLAELKSSIKIHPDLDDIVRKSIKRVNILSSMPGPALRAMIFHFIRDHILYSETWTAHHIEGYMLRAYQRTDQRSVAGKHFENFHRLAPIQMLEHDSEFKTSFLDAYNEELQSHIMRLLDSLFDPIQLDKKAKTFTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3V9</accession>
    <name>B8M3V9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Non-repetitive nucleoporin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_039060</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the non-repetitive/WGA-negative nucleoporin family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481136.1">
        <property type="nucleotide sequence ID" value="XM_002481091.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B8M3V9">
        <property type="interactions" value="1223"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M3V9"/>
    <dbReference type="GeneID" id="8107948"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_039060"/>
    <dbReference type="eggNOG" id="KOG1900">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000429_0_1_1"/>
    <dbReference type="InParanoid" id="B8M3V9"/>
    <dbReference type="OMA" id="SWAPFQK"/>
    <dbReference type="OrthoDB" id="338970at2759"/>
    <dbReference type="PhylomeDB" id="B8M3V9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051292">
        <property type="term" value="P:nuclear pore complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1880:FF:000004">
        <property type="entry name" value="Non-repetitive nucleoporin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1780:FF:000003">
        <property type="entry name" value="Non-repetitive nucleoporin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.440:FF:000001">
        <property type="entry name" value="Nuclear pore complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.450:FF:000002">
        <property type="entry name" value="Putative non-repetitive nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1880">
        <property type="entry name" value="Nucleoporin, helical C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.440">
        <property type="entry name" value="Nucleoporin, helical domain, central subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.450">
        <property type="entry name" value="Nucleoporin, helical domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004870">
        <property type="entry name" value="Nucleoporin_Nup155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042533">
        <property type="entry name" value="Nucleoporin_Nup155_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042537">
        <property type="entry name" value="Nucleoporin_Nup155_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042538">
        <property type="entry name" value="Nucleoporin_Nup155_C_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="14">
        <location>
            <begin position="109"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="13">
        <location>
            <begin position="664"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="34"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED20702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1353" mass="150949" checksum="0A33430C81C59695" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5J3</accession>
    <name>B8M5J3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PARP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_031460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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                <person name="Fedorova-Abrams N.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <sequence length="1548" mass="169933" checksum="1195D673F9F63B62" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6R0</accession>
    <name>B8M6R0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA topoisomerase</fullName>
            <ecNumber evidence="3 7">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_033720</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3 7"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480564.1">
        <property type="nucleotide sequence ID" value="XM_002480519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6R0"/>
    <dbReference type="FunCoup" id="B8M6R0">
        <property type="interactions" value="913"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M6R0"/>
    <dbReference type="GeneID" id="8097789"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_033720"/>
    <dbReference type="eggNOG" id="KOG1956">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002929_1_1_1"/>
    <dbReference type="InParanoid" id="B8M6R0"/>
    <dbReference type="OMA" id="VIHNVYS"/>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="PhylomeDB" id="B8M6R0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.140:FF:000005">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF21">
        <property type="entry name" value="DNA TOPOISOMERASE 3-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPO_IA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="9">
        <location>
            <begin position="5"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="10">
        <location>
            <begin position="170"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="529"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED20130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="660" mass="74363" checksum="7CDD56B437E3940A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B8M723</accession>
    <name>B8M723_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cytosolic iron-sulfur protein assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CIA1</name>
        <name evidence="6" type="ORF">TSTA_034780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480677.1">
        <property type="nucleotide sequence ID" value="XM_002480632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M723"/>
    <dbReference type="FunCoup" id="B8M723">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M723"/>
    <dbReference type="GeneID" id="8104320"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_034780"/>
    <dbReference type="eggNOG" id="KOG0645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_8_1"/>
    <dbReference type="InParanoid" id="B8M723"/>
    <dbReference type="OMA" id="IREIRWS"/>
    <dbReference type="OrthoDB" id="284782at2759"/>
    <dbReference type="PhylomeDB" id="B8M723"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000816">
        <property type="entry name" value="Probable cytosolic iron-sulfur protein assembly protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="130"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="177"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="410"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED20243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="443" mass="49266" checksum="4165F463E8126CAB" modified="2009-03-03" version="1">MWKISLVSDLTPPSLERIWQSSPHPTLPLVATSSADKTVRIYSLVNYKLLSIVSGGHKRSIRSSAWKPTPPATTGSSGRGESVLATGSFDATVGIWRRWDDYNNHNNDTGAEEGKDDDDEDEEWRFAVLLDGHDSEVKSVSWSASGSLLATCSRDKSIWIWEDLDDGDNNFETVAVLQEHTADVKCVAWHPVEECLASGSYDDTIRVWREDIDDWGQVACLKGHGGTVWFVDWEGVDYAPFTSTTPSTEPDDDQSAKIKEKYREHYRLSGPRIVSCSSDKTVRIWRRQAKQAQISTAFSASTTGIPSIIRPTGLDETWHQDATLPAAHDLAIYAVAWSKRSGLIASTGADGRIVVYTEEFVDNKKQKGNDEEMDTSPDTPFKTEWRIVASIEAAHGIYEVNHIAWAKRGDRRGEQKEDEMLISTGDDGSVKEENRATPNLMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8M776</accession>
    <name>B8M776_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSTA_035240</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480730.1">
        <property type="nucleotide sequence ID" value="XM_002480685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M776"/>
    <dbReference type="FunCoup" id="B8M776">
        <property type="interactions" value="275"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M776"/>
    <dbReference type="GeneID" id="8107474"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_035240"/>
    <dbReference type="eggNOG" id="KOG2747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011815_0_1_1"/>
    <dbReference type="InParanoid" id="B8M776"/>
    <dbReference type="OMA" id="YKLSAWE"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="PhylomeDB" id="B8M776"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046972">
        <property type="term" value="F:histone H4K16 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000067">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF219">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="16">
        <location>
            <begin position="14"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EED20296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="345" mass="39385" checksum="1B1AB8BEAECD9B27" modified="2009-03-03" version="1">MAQSAAANIAKQHANRGGVKRVVLGDLSFPTWYHSIYPEELVSKDTEILYVCRWCFRYTCDAGAYASHVKLCDRRTTPPGEKVYEHGGYAVWEIDGEDDKLFAQNLSLFAKLFLDHKSVFFDVSSFLYYVLTFTDPKTPDDYYVLGYFSKEKLSWDLNNLACILIFPPYQHKKLGKLLMGVSYKLSAWEWEGGLIGGPERPLSELGRRSYTRFWEERMARYFLLGPPGGDADEYVTMKTTTSGKNFPPRERMTVREIGQATGMLPEDVITALKGMGVVEPEKQHTTRTTSKRAQTTTSDGEAVIIRKSNVLEWTKIHNAALRDPVREYGFIGEWAPEKLQMQEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7E8</accession>
    <name>B8M7E8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Heat shock protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_035940</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I LYR family. SDHAF1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480802.1">
        <property type="nucleotide sequence ID" value="XM_002480757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7E8"/>
    <dbReference type="FunCoup" id="B8M7E8">
        <property type="interactions" value="1073"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M7E8"/>
    <dbReference type="GeneID" id="8101865"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_035940"/>
    <dbReference type="eggNOG" id="KOG4620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_1_1_1"/>
    <dbReference type="InParanoid" id="B8M7E8"/>
    <dbReference type="OMA" id="HFWAKER"/>
    <dbReference type="OrthoDB" id="4223605at2759"/>
    <dbReference type="PhylomeDB" id="B8M7E8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20268">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045295">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="9">
        <location>
            <begin position="137"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="107"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="190"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED20368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="316" mass="35841" checksum="8F39695678A7089E" modified="2009-03-03" version="1">MRRLSGLQREVLSLYRKCLREVRKKPQNTRDNFRAFAQAEFRKQLDVNKKDFSTIEHLLRKGHKQLETYSSPGIRNIKCSDKMSFYTTTLSPGDFLPLFQLMDDYCDTRRPASPKPAQSSRAKPSAAQSTPVALAPRQLTSFTPRFDVRELEKSYVLDGELPGAQQENIEIEFTDPETIVIKGQIERNYDVAPPSHSTTTDDNDDAMSVHSDGASSTHSNYHAPTVEDEEEDGAVKVSVQKTTNNSVTKQKQRPESAQEPKFKYWASERSIGTFQRTFTFPTRVDQDGVKATFKNGVLSVFVPKQAAQKAKRIRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7R1</accession>
    <name>B8M7R1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_030560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480224.1">
        <property type="nucleotide sequence ID" value="XM_002480179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7R1"/>
    <dbReference type="STRING" id="441959.B8M7R1"/>
    <dbReference type="GeneID" id="8101735"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_030560"/>
    <dbReference type="eggNOG" id="ENOG502STEY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_671168_0_0_1"/>
    <dbReference type="InParanoid" id="B8M7R1"/>
    <dbReference type="OMA" id="NTHILPR"/>
    <dbReference type="OrthoDB" id="4144003at2759"/>
    <dbReference type="PhylomeDB" id="B8M7R1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED19790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="46740" checksum="20BC1E1DDCDA987D" modified="2009-03-03" version="1">MEDASCPFVHHAGNNFPEKASSFLFVNKNALSGKLTRSDTIDEKVNILSHVQQRRRQRAEKVIKSTLGWEKSGLSVIATSKEQTASKSNAQHVPTVQKSTKDLLRIYPMDNATDPFHSTIVGTEAQMWTKIPTRCASILKTVNHGREASRIHLQAMIELVKSIGGWHKIDAYVLESMILVDKFSAMIDMTHPILPMTWVPEPLIQYNPEYQHSETADNLRRLGGNFVPMTVYYELAKTLQDIADFCRIAQWIWSRQDVSSKDESDMFLHLQSLNYRLLLLDKLSSTENCIRLAALVFLQNIIHYQGAQLSAILVIRHLKNALSEVSPHIQHSWDDECMLWILCTGAMATEATDEREWFLARTAYMSKNLSVDLGGLAFRELLEGYLFIWEKQDYQLSAMLENLCFAMDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7W1</accession>
    <name>B8M7W1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_031040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480274.1">
        <property type="nucleotide sequence ID" value="XM_002480229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7W1"/>
    <dbReference type="STRING" id="441959.B8M7W1"/>
    <dbReference type="GeneID" id="8107716"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_031040"/>
    <dbReference type="eggNOG" id="ENOG502SNS1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044368_2_0_1"/>
    <dbReference type="InParanoid" id="B8M7W1"/>
    <dbReference type="OMA" id="THEILCE"/>
    <dbReference type="OrthoDB" id="5423818at2759"/>
    <dbReference type="PhylomeDB" id="B8M7W1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED19840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="45489" checksum="1D6996707E967D90" modified="2009-03-03" version="1">MAQINVPAFSSTSLTGDDFTFNDLFPSGGTTDTVGAQIDIDWDALGDISTQTLKTSLPRLNDPMPKVTSSGPFLLCNPDGVSPNLDPENLLQPQKLPSSALTIRDGYSSTLSGPAQPYERPESNFLARLPISDPVSHFIATSVIQMIRTYPLMMLRTETLPSFIHGHWYRPSGGIEPSLPEPLVNCMGIAQIFASHNTESKPFLWRIVKIEQRSFIEKNDQRQFSREDLLAAIQAQIMYVIMRIIDDSKMDQGMNLEMLVTHEILCESLVQLCNEPFCQDERLYPSSSWEDWVFAESKRRTALVWFLIAQTIHIKTGVSCETISGFQDLPLCSPKSLWEAKTRSAWQAEYEMYQSMPRNGPDVFGDLIDACKQSDTGSGRLKLDTWNANADNLGIILSMSAAMMAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B8M890</accession>
    <name>B8M890_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSTA_036290</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="5"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480837.1">
        <property type="nucleotide sequence ID" value="XM_002480792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M890"/>
    <dbReference type="FunCoup" id="B8M890">
        <property type="interactions" value="996"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M890"/>
    <dbReference type="GeneID" id="8101900"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_036290"/>
    <dbReference type="eggNOG" id="KOG2245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011511_4_1_1"/>
    <dbReference type="InParanoid" id="B8M890"/>
    <dbReference type="OMA" id="STRDIML"/>
    <dbReference type="OrthoDB" id="412748at2759"/>
    <dbReference type="PhylomeDB" id="B8M890"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="16">
        <location>
            <begin position="63"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="15">
        <location>
            <begin position="134"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="14">
        <location>
            <begin position="196"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="249"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="363"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EED20403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="420" mass="46140" checksum="35517540A892294C" modified="2009-03-03" version="1">MAAQSTRQFGVTPPISTLQLIQRVVIEFVKTVGRRKGLSPAALEAAGGKIFTYGSYRLGVYGPVPDAFVPIIKLEFSGISLDLIFARLILPSIPLNLDLKNNGYLRGLDDKEVRSLNGTRVTDQILELVAQQKTFRLALRAIKLWAQRRAIYSNIVGFPGGVAWAMLVARVCQLGDIVEKIFAKQLTWNDLFTRHTFFSRDYKYYLQITASSKTKEADSVWSGLVESKLRHLVGVERIHVVKDDAEAEQVKNGSTKYQAQGTKTETTDETKDPAHTAAAETGAEDAQVPDPATNGAVDSRTIYTTTYYIGLELEPLEPGASRSLDIPTDADVFESTCTSWRGFQEGINDLSITHVRSFDLPDDAFEPGETRPVRPKKKVAKPATAAAPQKRSIDAVDGTMHPEAKRQVSSNGFTHAATPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2024-01-24" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B8M937</accession>
    <name>B8M937_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_111680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481324.1">
        <property type="nucleotide sequence ID" value="XM_002481279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M937"/>
    <dbReference type="STRING" id="441959.B8M937"/>
    <dbReference type="GeneID" id="8098823"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_111680"/>
    <dbReference type="HOGENOM" id="CLU_1295164_0_0_1"/>
    <dbReference type="InParanoid" id="B8M937"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED17332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="213" mass="23568" checksum="B688AF639E0EA1E3" modified="2009-03-03" version="1">MNLTVTVGTTILTLRVSAPDISSLGRFVLVPCYRLCFVIRTIAKLTIIKARDVIFNEDEVFNGNLERLKDDVRDIPLPESAELLMKTNITQEGQILGSNSESEELSPEEDTILLGNPLSVEESVEDINIEEDLDQDQISAIPETKKNLAGTEEFAYPTPLETPLAALLSATIKISDDLDTLANNLLGEESKQVDSEFRPWNASFLAGQRQSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9V8</accession>
    <name>B8M9V8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Origin recognition complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_118760</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the origin recognition complex (ORC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ORC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482102.1">
        <property type="nucleotide sequence ID" value="XM_002482057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9V8"/>
    <dbReference type="FunCoup" id="B8M9V8">
        <property type="interactions" value="973"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M9V8"/>
    <dbReference type="GeneID" id="8108550"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_118760"/>
    <dbReference type="eggNOG" id="KOG2928">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018596_2_0_1"/>
    <dbReference type="InParanoid" id="B8M9V8"/>
    <dbReference type="OMA" id="AHERYFF"/>
    <dbReference type="OrthoDB" id="346673at2759"/>
    <dbReference type="PhylomeDB" id="B8M9V8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056773">
        <property type="entry name" value="WHD_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24882">
        <property type="entry name" value="WHD_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="7">
        <location>
            <begin position="234"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 winged-helix" evidence="8">
        <location>
            <begin position="485"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="150"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED18110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="556" mass="62384" checksum="7EC401DE5937AFAA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9Z5</accession>
    <name>B8M9Z5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dihydrodipicolinate synthetase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_119110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482139.1">
        <property type="nucleotide sequence ID" value="XM_002482094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9Z5"/>
    <dbReference type="STRING" id="441959.B8M9Z5"/>
    <dbReference type="GeneID" id="8104361"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119110"/>
    <dbReference type="eggNOG" id="ENOG502QWNS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_0_2_1"/>
    <dbReference type="InParanoid" id="B8M9Z5"/>
    <dbReference type="OMA" id="FHFAMNE"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="PhylomeDB" id="B8M9Z5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF66">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="3">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED18147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="334" mass="35963" checksum="D71E9F2C57239DB2" modified="2009-03-03" version="1">MGSTSKTGTPYPPGIHVPSLTWFKSDETQTIDWDVQRKHLEFLIGSGLPGVVICGTNGEAAAVTPQEKSKLISLTRLVAQELGRADITITCGTYGGCTQAIIEDTKLAAEAGADFVLVLVPSFFHFALDQDAIVGFYQEVASASPIPIVIYNFPGVVSGLNVNSEMLQVLGDHSNIVAVKLTCGTIASVARTVANFGPGLDLKNNKYAGQPRFVALAGQSDWLVPCLSVGGTGCVTGMANLYPKTCIEIFNLYVAGKKTEAEELQIKLASVEWGFGKGGINGTKWVVGKFLGYPEESTWCRRPYPKFLDNGKREWIETIVKPLQEIETALDKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MA64</accession>
    <name>B8MA64_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_121360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482385.1">
        <property type="nucleotide sequence ID" value="XM_002482340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MA64"/>
    <dbReference type="STRING" id="441959.B8MA64"/>
    <dbReference type="GeneID" id="8099376"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_121360"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_23_8_1"/>
    <dbReference type="InParanoid" id="B8MA64"/>
    <dbReference type="OrthoDB" id="4842715at2759"/>
    <dbReference type="PhylomeDB" id="B8MA64"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="289"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED18393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="581" mass="65295" checksum="BCFB1A986A16DEDA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAR7</accession>
    <name>B8MAR7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor YJU2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_115540</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CWC16 family. YJU2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481749.1">
        <property type="nucleotide sequence ID" value="XM_002481704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAR7"/>
    <dbReference type="STRING" id="441959.B8MAR7"/>
    <dbReference type="GeneID" id="8099581"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_115540"/>
    <dbReference type="eggNOG" id="KOG2989">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053603_1_0_1"/>
    <dbReference type="InParanoid" id="B8MAR7"/>
    <dbReference type="OMA" id="ENCDYQN"/>
    <dbReference type="OrthoDB" id="674963at2759"/>
    <dbReference type="PhylomeDB" id="B8MAR7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03226">
        <property type="entry name" value="YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043701">
        <property type="entry name" value="Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF1">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="115"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED17757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="271" mass="31323" checksum="1ED7E9B781E5880E" modified="2009-03-03" version="1">MSERKVLTKYYPPDFDPSAITRTKKVPGVKQKLLTVRLMAPFSMRCTSCGEYIYKGRKFNARKETTEEKYLSIAIYRFYIRCTRCSGEITFKTDPKNMDYVCERGAKRNFEPWRNTQADNLNETEEETLDRLEREENEELEQLERDKMAELEEKMLDSKREMAVADALDEIRTRNARIERGEALGEDVALAYVKDEAEEARLRAEKEDEEIARRAFMTSTGQKVKRLVEDEEETAAKTAETPAPAMSFAKARKPKKPFNAGLGIKKKASLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8MB83</accession>
    <name>B8MB83_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-demethoxyubiquinone hydroxylase, mitochondrial</fullName>
            <shortName evidence="8">DMQ hydroxylase</shortName>
            <ecNumber evidence="8">1.14.99.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ubiquinone biosynthesis monooxygenase COQ7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">COQ7</name>
        <name evidence="10" type="ORF">TSTA_125840</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + AH2 + O2 = a 3-demethylubiquinol + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:50908"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="1.14.99.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="8">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the COQ7 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.60" evidence="8"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482864.1">
        <property type="nucleotide sequence ID" value="XM_002482819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MB83"/>
    <dbReference type="FunCoup" id="B8MB83">
        <property type="interactions" value="367"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MB83"/>
    <dbReference type="GeneID" id="8098096"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_125840"/>
    <dbReference type="eggNOG" id="KOG4061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071892_0_0_1"/>
    <dbReference type="InParanoid" id="B8MB83"/>
    <dbReference type="OrthoDB" id="275371at2759"/>
    <dbReference type="PhylomeDB" id="B8MB83"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008682">
        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01042">
        <property type="entry name" value="DMQH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01658">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237:SF4">
        <property type="entry name" value="5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="COENZYME Q10 BIOSYNTHESIS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="2 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
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        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
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        <location>
            <position position="165"/>
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        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
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        <location>
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        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
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        </ligand>
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        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
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        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
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        </ligand>
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            <position position="298"/>
        </location>
        <ligand>
            <name>Fe cation</name>
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        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED18872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="334" mass="37800" checksum="CCC8EE7ACD82D14C" modified="2009-03-03" version="1">MKIRSREVAVVIQGVIVVSTVPELLESKARCYAGSKAAKSLGRRHHQLLRATTTIGLFFIQEVETMCPAANSLQYRVLRIPRGVFTPQTPLYLDFLAPSTVRHSSRRCFFFSAKTSTRDVAEPAEPREPFEQNRSSSPSAKPRYVLSRAQRVYLDRALRVNQAGELAATLIYAAQKPPILRSHPHLRPLMKHMYDQEAVHFAKFNHLVAKHQVRPTAMYPIWEVAATFLGWSTAIMGREAAMACTEAVETEIGTHYNEQVSTIIGWMKEAEQRGEEVDDEIKDLLALLRKTRDEELEHLDHAVENDSKEAKPYDPLVNIIRTGCRAAINISERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBM8</accession>
    <name>B8MBM8_TALSN</name>
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        <submittedName>
            <fullName evidence="8">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_119250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat cdt2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EED18161.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002482108.1"/>
    </dbReference>
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    <dbReference type="STRING" id="441959.B8MBM8"/>
    <dbReference type="GeneID" id="8104375"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119250"/>
    <dbReference type="eggNOG" id="KOG0321">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018451_0_0_1"/>
    <dbReference type="InParanoid" id="B8MBM8"/>
    <dbReference type="OMA" id="RTAHNNR"/>
    <dbReference type="OrthoDB" id="2096344at2759"/>
    <dbReference type="PhylomeDB" id="B8MBM8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051865">
        <property type="entry name" value="WD-repeat_CDT2_adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852:SF0">
        <property type="entry name" value="DENTICLELESS PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852">
        <property type="entry name" value="LETHAL 2 DENTICLELESS PROTEIN RETINOIC ACID-REGULATED NUCLEAR MATRIX-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="295"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="337"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
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            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="699"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED18161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="726" mass="80109" checksum="15F819D62F7D2E50" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBN1</accession>
    <name>B8MBN1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_119280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482156.1">
        <property type="nucleotide sequence ID" value="XM_002482111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBN1"/>
    <dbReference type="GeneID" id="8104378"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119280"/>
    <dbReference type="eggNOG" id="ENOG502RR01">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_375955_0_0_1"/>
    <dbReference type="InParanoid" id="B8MBN1"/>
    <dbReference type="OMA" id="ANWERME"/>
    <dbReference type="OrthoDB" id="4524386at2759"/>
    <dbReference type="PhylomeDB" id="B8MBN1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="564"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="664" mass="74510" checksum="087F07CF8CCF91DE" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBQ5</accession>
    <name>B8MBQ5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_119500</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482180.1">
        <property type="nucleotide sequence ID" value="XM_002482135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBQ5"/>
    <dbReference type="STRING" id="441959.B8MBQ5"/>
    <dbReference type="GeneID" id="8105225"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119500"/>
    <dbReference type="eggNOG" id="KOG2666">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023810_7_0_1"/>
    <dbReference type="InParanoid" id="B8MBQ5"/>
    <dbReference type="OMA" id="EWARIAY"/>
    <dbReference type="OrthoDB" id="5059218at2759"/>
    <dbReference type="PhylomeDB" id="B8MBQ5"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000001">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000032">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374:SF3">
        <property type="entry name" value="UDP-GLUCOSE 6-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="436"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="266"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="369"/>
            <end position="373"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED18188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="637" mass="69732" checksum="881EC117813BFC5D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBV0</accession>
    <name>B8MBV0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Chromatin-remodeling ATPase INO80</fullName>
            <ecNumber evidence="15">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TSTA_119890</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the INO80 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The DBINO region is involved in binding to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="15"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482225.1">
        <property type="nucleotide sequence ID" value="XM_002482180.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B8MBV0">
        <property type="interactions" value="1090"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MBV0"/>
    <dbReference type="GeneID" id="8105263"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119890"/>
    <dbReference type="eggNOG" id="KOG0388">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_26_1_1"/>
    <dbReference type="InParanoid" id="B8MBV0"/>
    <dbReference type="OMA" id="NLLGFHC"/>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="PhylomeDB" id="B8MBV0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032006">
        <property type="term" value="P:regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18002">
        <property type="entry name" value="DEXQc_INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000006">
        <property type="entry name" value="Putative DNA helicase INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001269">
        <property type="entry name" value="SNF2 family helicase/ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020838">
        <property type="entry name" value="DBINO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031047">
        <property type="entry name" value="DEXQc_INO80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
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            <begin position="1381"/>
            <end position="1541"/>
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            <end position="271"/>
        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="513"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
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    </feature>
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        <location>
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        </location>
    </feature>
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            <begin position="1566"/>
            <end position="1662"/>
        </location>
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        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
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        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
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            <begin position="182"/>
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        </location>
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            <end position="237"/>
        </location>
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        </location>
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        </location>
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            <dbReference type="PROSITE" id="PS51194"/>
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        </source>
    </evidence>
    <sequence length="1662" mass="189256" checksum="535F91D2CF004DF9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8MC04</accession>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    </dbReference>
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        </location>
    </feature>
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        <source>
            <dbReference type="EMBL" id="EED18450.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="263" mass="29641" checksum="52E986B64F09E579" modified="2009-03-03" version="1">MSDPTFLDAKVSSILGQKLDSSRTDPGDLDEDALFEELEKEDDSAYRAHRLEQLHKEVVSAKEALKQNTPNNNNNNTTTTIDAFYPTLVDDRAVLDLTTNNERCIVHFSHTDFARCTVMDEHLRLLAPRHHEVRFARIDVRNCPFVVEKLNIRVLPCVIGFVDGNGKERIIGFEGLVSIGKSALRGKGADNFRTTDLEKRLVQAGILVRGKYVEEIGRNNDEGDMSESESENERGGKSSRRKGIRDGTSSRRYGQDNSDDDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCJ6</accession>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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            <dbReference type="PubMed" id="25676766"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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            <name>FAD</name>
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        </cofactor>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_4_2_1"/>
    <dbReference type="InParanoid" id="B8MCJ6"/>
    <dbReference type="OMA" id="FGTHANN"/>
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    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="188"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED18812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="461" mass="49059" checksum="C55A90AD2AC7E5CE" modified="2009-03-03" version="1">MGLIDSIVSATLVSAYLGAGSAVNVNDLAPSLTAAGTTVTSKSSYVPPLFHGEIIQLTDQALADAAIQIHNATISDLFSFGTHANNTSESPGHLHSCKVLPGDPSWPSDDVWETSSSLLGNRLIRVVPLAASCYPDWPNYNLESCATVVGQWLNSSLHTGDPTSIMYPLYEGRSCMASGFNYTGTCLQGAYPSFVVNASTVAQIQLAVNFARNSNIRLVVKNTDHDFIGKGSGKGALSIWTHWLKDKAYYPSFTAANGYQGPAIKFGAGIQVFEAYEFAKGFGVTVIGGEAITVGLAGGYTAGGGRSPLSSLYGMAADQVLALEVVLADGSFVTATAKENPDIYWILRGGGGSTIGVVVSLTTRVYAQLQTTTATFNFTVANTPSVDAFWSAVQSYIDNIERFVDAGTFGYYDVVASAIEFGTDYTGDRDYYFRMQSFVAPNMTIPRLRSCWIPGSELSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCS6</accession>
    <name>B8MCS6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_126860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482970.1">
        <property type="nucleotide sequence ID" value="XM_002482925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCS6"/>
    <dbReference type="STRING" id="441959.B8MCS6"/>
    <dbReference type="GeneID" id="8099113"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_126860"/>
    <dbReference type="eggNOG" id="ENOG502SJ8Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004804_0_2_1"/>
    <dbReference type="InParanoid" id="B8MCS6"/>
    <dbReference type="OMA" id="YEYSRIT"/>
    <dbReference type="OrthoDB" id="5392779at2759"/>
    <dbReference type="PhylomeDB" id="B8MCS6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="29"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED18978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="755" mass="84895" checksum="B2D984B2C39DD603" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDB8</accession>
    <name>B8MDB8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_114530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481635.1">
        <property type="nucleotide sequence ID" value="XM_002481590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MDB8"/>
    <dbReference type="GeneID" id="8109215"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_114530"/>
    <dbReference type="HOGENOM" id="CLU_128542_0_0_1"/>
    <dbReference type="InParanoid" id="B8MDB8"/>
    <dbReference type="OMA" id="KSRITHH"/>
    <dbReference type="OrthoDB" id="4354814at2759"/>
    <dbReference type="PhylomeDB" id="B8MDB8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20731" checksum="9DDDF360CFA24F32" modified="2009-03-03" version="1">MAYKAQAVRNSFTATGLVPFNPDRVYQQLTVRLKTPTPPPSRSSDTQSSCLQTPQNPRQFKRQMTTMKKRISWHTRSSSEAIGEVFTRASKAYEKELHDLRAAHEKEKQKRQKSKKQISHDHGITREEAQALVQGQIEASQAVTTAPAEPELPVSHPPVRRQFRCSGCGIEGHKITGCPNRTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDE1</accession>
    <name>B8MDE1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Efflux pump antibiotic resistance protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_116920</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481896.1">
        <property type="nucleotide sequence ID" value="XM_002481851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MDE1"/>
    <dbReference type="FunCoup" id="B8MDE1">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="GeneID" id="8102084"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_116920"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="InParanoid" id="B8MDE1"/>
    <dbReference type="OMA" id="GSAYFMC"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="PhylomeDB" id="B8MDE1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF177">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="57"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED17904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="561" mass="60880" checksum="F6A899A1563066F4" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDY5</accession>
    <name>B8MDY5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_011710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483296.1">
        <property type="nucleotide sequence ID" value="XM_002483251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MDY5"/>
    <dbReference type="STRING" id="441959.B8MDY5"/>
    <dbReference type="GeneID" id="8100160"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_011710"/>
    <dbReference type="eggNOG" id="ENOG502S9BI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_571312_0_0_1"/>
    <dbReference type="InParanoid" id="B8MDY5"/>
    <dbReference type="OrthoDB" id="66095at2759"/>
    <dbReference type="PhylomeDB" id="B8MDY5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="478" mass="53837" checksum="5A2D1BCEC43D32AC" modified="2009-03-03" version="1">MYLAFFRKVMLYGERCISADESLGSHENQAHLFTTISSNIVLRNPVFKEIEGLPPASRGRIRTPTNKYLATSSQKLPASRHRHSTLRLSVQAEVLQSLNIHTCHSLKPPSSGRPMSFLAEVFLLLVFYTVTRYFANDGMNHTGNRVPLRYRGRGGRRTVLPSYPQHNEAETTSKISGSVDSDDTEDTDVPDDTQHKEFYPSLEDVSEVRNILRRLWSSSSKSSSRRNVMLPDEVIDIILDEAEYWPSMVTKLDTTPFVISADGDRECLKTPPLCYSLAKEGKKSQEEASPTGQESSPRILLHRGIHPCRKIVFDISSHDQGWGGESAHRGTFTGSWTWFDAYIRPSTPKDDADDGRKASDTTTATTTRSADSDSSSEGTPSSHLRPFLPEPTKLQCNRTATINSTDYHIFWHYRDNLPADSPEAERIERETGRGRATLDGNAVRNMKVGDEVSVWLRARFAGWRNHVDKMSVRVFWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEH7</accession>
    <name>B8MEH7_TALSN</name>
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        <recommendedName>
            <fullName evidence="1">Alpha-L-rhamnosidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_016790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483838.1">
        <property type="nucleotide sequence ID" value="XM_002483793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEH7"/>
    <dbReference type="STRING" id="441959.B8MEH7"/>
    <dbReference type="GeneID" id="8103652"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_016790"/>
    <dbReference type="HOGENOM" id="CLU_2559863_0_0_1"/>
    <dbReference type="InParanoid" id="B8MEH7"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="PhylomeDB" id="B8MEH7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307:SF6">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="1">
        <location>
            <begin position="22"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="82" mass="9047" checksum="1C376C68BCA60E77" modified="2009-03-03" version="1">MTSFNHYALGSIINWLHKTVAGVSPLEPGWRKILIHPLPGGTVTSAEAVYDTPYDRLECRCCAAQFDGEGDPSIWSIEDGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8MES8</accession>
    <name>B8MES8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_020200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484195.1">
        <property type="nucleotide sequence ID" value="XM_002484150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MES8"/>
    <dbReference type="STRING" id="441959.B8MES8"/>
    <dbReference type="GeneID" id="8108831"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_020200"/>
    <dbReference type="HOGENOM" id="CLU_1284038_0_0_1"/>
    <dbReference type="InParanoid" id="B8MES8"/>
    <dbReference type="OrthoDB" id="6910977at2759"/>
    <dbReference type="PhylomeDB" id="B8MES8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED16961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="215" mass="24183" checksum="208C2B9F049F3002" modified="2009-03-03" version="1">MSPDSVQVKAEAQDYAHQSTFLYDMAHGLPLTPSVSAHGWQDHSIAGTTACYSTALSAPDYGGLSFYQQQQYTDPTMVSTASVQYPLFTSSPQVQGLYYHAGYSFNQTSHPEFAQITRGHHPHSPTKIQEGMKERILNPSSDHPLKKPSPYLVPSRAKAGHIMDRFLLGFMSQRWDQVAGRNQVLERRARLNLIPIYVAQYVIRFLRDGRIARSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEV5</accession>
    <name>B8MEV5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ndc10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_022920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484472.1">
        <property type="nucleotide sequence ID" value="XM_002484427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEV5"/>
    <dbReference type="STRING" id="441959.B8MEV5"/>
    <dbReference type="GeneID" id="8107129"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_022920"/>
    <dbReference type="eggNOG" id="ENOG502QTWE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1983058_0_0_1"/>
    <dbReference type="InParanoid" id="B8MEV5"/>
    <dbReference type="OrthoDB" id="4325529at2759"/>
    <dbReference type="PhylomeDB" id="B8MEV5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.20">
        <property type="entry name" value="Centromere DNA-binding protein complex CBF3 subunit, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038279">
        <property type="entry name" value="Ndc10_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031872">
        <property type="entry name" value="NDC10_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16787">
        <property type="entry name" value="NDC10_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ndc10" evidence="1">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="126" mass="14455" checksum="4E4938AA3AA2F6C6" modified="2009-03-03" version="1">MAGLSALAIYFFWRWHYSRESFPCFWTSQDWYNIKVLKRDNNHLTEPLSDSTAASWTRRLYSEAGIKSSKVTHAGWVSGARLAELNGVSEDQIRRGGRWNADQMTGCYLTTLPQSFMHGIADFDPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEW5</accession>
    <name>B8MEW5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_023020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002484437.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="8107139"/>
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    <dbReference type="eggNOG" id="ENOG502T439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_680034_0_0_1"/>
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    <dbReference type="OrthoDB" id="5084510at2759"/>
    <dbReference type="PhylomeDB" id="B8MEW5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED17248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="405" mass="46827" checksum="9F7D04F569D89641" modified="2009-03-03" version="1">MLPNEEIEEAVGSPSPVIEISDEEEDNHTRPQPRRRHPGRPDYTYQDYQDTVEHVILAPPLRKRKSEDSDAADFQSKIKRFVKEIQGPYEALEKENKRLTQERHQWKNDKKQLWLQIRYLQRQLDGQKRRNILKFYRPSHLVQPISKRQYTDGINAVNEPITPKSPILECEIPETEDALESMICVDAAELRSAYEHESKPDVHSTTLVMHGEDLLKSENIDYSTMPICPDGEQVESPPVPEEDLTKGLSFLDTVYQMVDIVHLLKKHPSDLPRTVHQSILQSLRTNQGPIIDSTVSHWSDGKMWMKVLERGSATNRRCTVLNMLEYMGASKWYDGQIELARRTVCTKDNKAVGEKGAAMHVMNRITDEHSLLSRKVIINQFSRGKRLRVLVEEIRLGILISPKIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEX6</accession>
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            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="1" type="ORF">TSTA_023130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="8109965"/>
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    <dbReference type="HOGENOM" id="CLU_136368_0_0_1"/>
    <dbReference type="InParanoid" id="B8MEX6"/>
    <dbReference type="OMA" id="LEWGERE"/>
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    <dbReference type="PhylomeDB" id="B8MEX6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED17259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="12716" checksum="3929B34F1FA87465" modified="2009-03-03" version="1">MTASLLTLDVKGAFDAVLPGRLIRRLRNPRNRFGYTDDAANLAISTSLATNCEALSDSLQEALNWGAAEGITFALDKYELLHFSQHKADQDPTYTPSVKAGSIIISENTKWLYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B8MF08</accession>
    <name>B8MF08_TALSN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">TSTA_009020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483011.1">
        <property type="nucleotide sequence ID" value="XM_002482966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MF08"/>
    <dbReference type="GeneID" id="8100763"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_009020"/>
    <dbReference type="HOGENOM" id="CLU_2160107_0_0_1"/>
    <dbReference type="InParanoid" id="B8MF08"/>
    <dbReference type="OrthoDB" id="5233426at2759"/>
    <dbReference type="PhylomeDB" id="B8MF08"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED15777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="111" mass="12630" checksum="869A56B5CF4009AC" modified="2009-03-03" version="1">MADKTALSNTEHIAGENALKHYVLTGGWRNAHFIKEPDLPKSSIIDYYCDSLERIANFAKKWGTSFHRSHMTPSLSQHHCVLHDMDARHLDFNIDPEVGKDGCKPLDQEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFK6</accession>
    <name>B8MFK6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_020530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFK6"/>
    <dbReference type="GeneID" id="8108863"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_020530"/>
    <dbReference type="HOGENOM" id="CLU_145601_0_0_1"/>
    <dbReference type="InParanoid" id="B8MFK6"/>
    <dbReference type="OrthoDB" id="4439444at2759"/>
    <dbReference type="PhylomeDB" id="B8MFK6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED16996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="151" mass="16900" checksum="6A699C1DD0A3C6ED" modified="2009-03-03" version="1">MEYNSVTDLYYGVSLKNGPITLTPNLPEPRVAKTQQTITPTTLPSLRHRDSTALMAPINFRNGHHCQACNNIHIHSSRQVALDEDIIALELAQEELKFVSQSVEQLLDVMRNGDGQQLETLFAAARSGVSQDEILAMARQFTRGKEREDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFY4</accession>
    <name>B8MFY4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_009720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483085.1">
        <property type="nucleotide sequence ID" value="XM_002483040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFY4"/>
    <dbReference type="STRING" id="441959.B8MFY4"/>
    <dbReference type="GeneID" id="8102768"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_009720"/>
    <dbReference type="eggNOG" id="ENOG502S3CQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8MFY4"/>
    <dbReference type="OMA" id="WGMEISA"/>
    <dbReference type="OrthoDB" id="4223075at2759"/>
    <dbReference type="PhylomeDB" id="B8MFY4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="611"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="728"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="626"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="743"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED15851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="752" mass="81894" checksum="E267103670A3766D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B8MI93</accession>
    <name>B8MI93_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_040570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484530.1">
        <property type="nucleotide sequence ID" value="XM_002484485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MI93"/>
    <dbReference type="GeneID" id="8110014"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_040570"/>
    <dbReference type="HOGENOM" id="CLU_1897605_0_0_1"/>
    <dbReference type="InParanoid" id="B8MI93"/>
    <dbReference type="OrthoDB" id="10636042at2759"/>
    <dbReference type="PhylomeDB" id="B8MI93"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="134" mass="14426" checksum="E31B370C2F03E638" modified="2009-03-03" version="1">MHDPVHAPLDAGYAAPQSILKRAMSTAAQPWSLISALLDAYTVIDHIQLTSQTQQAEIRKSCAINLAKARTEGGCSSQLSIGTQETPMALDEMPSQPPTHEIISPFRSVTPPPRAPTEDPPITARAVRFTTSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIM4</accession>
    <name>B8MIM4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_045730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485069.1">
        <property type="nucleotide sequence ID" value="XM_002485024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIM4"/>
    <dbReference type="STRING" id="441959.B8MIM4"/>
    <dbReference type="GeneID" id="8107560"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_045730"/>
    <dbReference type="eggNOG" id="ENOG502RZG9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005297_0_0_1"/>
    <dbReference type="InParanoid" id="B8MIM4"/>
    <dbReference type="OrthoDB" id="10248252at2759"/>
    <dbReference type="PhylomeDB" id="B8MIM4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF2">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G04300)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="471"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED15116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1022" mass="114205" checksum="1F1B7D7158169E6E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJP9</accession>
    <name>B8MJP9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_051850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485701.1">
        <property type="nucleotide sequence ID" value="XM_002485656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJP9"/>
    <dbReference type="STRING" id="441959.B8MJP9"/>
    <dbReference type="GeneID" id="8103406"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_051850"/>
    <dbReference type="eggNOG" id="KOG1121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017134_1_0_1"/>
    <dbReference type="InParanoid" id="B8MJP9"/>
    <dbReference type="OMA" id="NDKRINW"/>
    <dbReference type="OrthoDB" id="2677621at2759"/>
    <dbReference type="PhylomeDB" id="B8MJP9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="9">
        <location>
            <begin position="67"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED15748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="388" mass="43768" checksum="CB1D9EB965989FDA" modified="2009-03-03" version="1">MSQLSRFSDAGPSSFLGSDIPDDFTSYSMTTPATSLAQDQPAISFKSFLSTTDTGSPIPESLQLVGPDRRKSWVLWSEMNKDDFIRDPQVMCKQCGKTLPHPQKTSNGTNSMKRHLSGAKCVKAAFDTTQQQNIQESLQFATIKVFNDEDWTQTQIELIANSHLPFQFLAHKGLINLIQYACLAPTMPNLLSPTTARRQLGLQVKRRQAEILSYLPPGAKISVALDCWTSPFQQAFIAITRYFIDKNWQYREILLGFEPLYDRHTSINLSAVLLETLQQHDLVDRVLALTTDNASNNKTLLRAFNDAIESPDIPEELRLVRIPCLAHVIQLSLKDLLCLMKVNLKNDNPDQAWSDEEAERLRQIRREKGISYTLAKIRGLAIFINASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJX4</accession>
    <name>B8MJX4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vitamin B6 transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_042660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484744.1">
        <property type="nucleotide sequence ID" value="XM_002484699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJX4"/>
    <dbReference type="STRING" id="441959.B8MJX4"/>
    <dbReference type="GeneID" id="8103358"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_042660"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_5_1"/>
    <dbReference type="InParanoid" id="B8MJX4"/>
    <dbReference type="OMA" id="WFAFTSS"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="PhylomeDB" id="B8MJX4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF36">
        <property type="entry name" value="MEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
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        <source>
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    <sequence length="461" mass="51929" checksum="6B3DDC758F9A3904" modified="2009-03-03" version="1">MAATNVMTAPALPDPPIMNETPETYHYVPQDLSSKIPQTASLEVSQEIPQEEQSQESSHVVEPEIPETIQELPKEVAQELSTEEVKVTRQKPSTREGKPIIPVKDDLPPSERVTFDPAKHIKFTPPSKVWTMQELDYAEGQGISPVGVSEPFPLFSEEAVKQMRAEILSEKVWDKYKYSSNLSQCQLRGYAPECAPFIYDAWKSPEVLEIISKIAGIDLVPVMDWEIAHINIAVKSEEEKAKELEIVHRNADEGVADCALEEDDQPVVDWHTDSYPFVCVTMLSDCTTMVGGETMLRKGNGGTVKVRGPQMGSAVILQGRYIEHQALRALGAAERITSVTSFRPRSAAVKDDTVLTTVRGISDLKELYHQYAEYRFEILQDRFQAMGRKLRDRKRASRPFDTAATKRFIREQIEFLEAMDREMVSDELVQKGYIGDGHLVSEETRQTAKRRGLYVEETVAA</sequence>
</entry>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED15362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="234" mass="23460" checksum="458A2D3AD9239C90" modified="2009-03-03" version="1">MRPFFSLALASVATAHFTLDWPVSRGFNEDTMPTFPCGGFNTPVSNRTVIALDAHSIPVDITFHHTQTAVSYLLALGNDPGSSFNITLGPTLAATGLGEFCLPDISLSSLNLTDGQNATLQVITDGDSGGGLFACADITFSSSVAKNSPSKCANNTGVTATALSGADGARTANFSNPDGSPRSASPSSSTSSGSSSTSATASAASSTHTGAAVTLETAGWGVLGSAFVACLALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B8ML41</accession>
    <name>B8ML41_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_048970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485410.1">
        <property type="nucleotide sequence ID" value="XM_002485365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ML41"/>
    <dbReference type="GeneID" id="8100613"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_048970"/>
    <dbReference type="HOGENOM" id="CLU_3034004_0_0_1"/>
    <dbReference type="InParanoid" id="B8ML41"/>
    <dbReference type="OrthoDB" id="5420958at2759"/>
    <dbReference type="PhylomeDB" id="B8ML41"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="55" mass="6188" checksum="B7EC3B9C3AB20024" modified="2009-03-03" version="1">MLNIGDLDRNSPVDQLQKRRTRRTRPLQAEGILTVSEGRELAQEAEEAVNPPCSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLY2</accession>
    <name>B8MLY2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposable element tc3 transposase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_097500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485732.1">
        <property type="nucleotide sequence ID" value="XM_002485687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLY2"/>
    <dbReference type="STRING" id="441959.B8MLY2"/>
    <dbReference type="GeneID" id="8108389"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_097500"/>
    <dbReference type="eggNOG" id="ENOG502QUTZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033666_0_1_1"/>
    <dbReference type="InParanoid" id="B8MLY2"/>
    <dbReference type="OMA" id="CIEVILA"/>
    <dbReference type="OrthoDB" id="4349822at2759"/>
    <dbReference type="PhylomeDB" id="B8MLY2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052338">
        <property type="entry name" value="Transposase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022:SF119">
        <property type="entry name" value="TC1-LIKE TRANSPOSASE DDE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022">
        <property type="entry name" value="TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13384">
        <property type="entry name" value="HTH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="2">
        <location>
            <begin position="104"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="3">
        <location>
            <begin position="159"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED13494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="355" mass="41407" checksum="5CC5DC3339D7579D" modified="2009-03-03" version="1">MATPEPTSPPRATSAAALEPSDSRQNSARLNRDERIRVLTLRDAGFTYLQISQQLQISYRQVQYTCQSQQATPKKARGNSPKLSEAEVDHIIEWITSSKRTRQLNLSIGKHALARALKKRGYTRCKALNKPPLSDKHKQVRLAWALEHLNWTTEQWNRILWSDETWVTSGFHTRIWVTRKAGEELEETCIRSSPARKRGWMFWATFHGNNKGPCLFWEKEWGTINSERYCQRVIPIIDGYICLLRDDIWLQFMQDGAPGHASKETLEELHSRGIYPIYWPAFSPDLNPIEAVWNWMKDWIQEQYPDDEQLSYDRLREIVRAAWDALPEQFLKELIDSMHARCQAVIDARGGHTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MM12</accession>
    <name>B8MM12_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbonyl reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_097800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485762.1">
        <property type="nucleotide sequence ID" value="XM_002485717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MM12"/>
    <dbReference type="STRING" id="441959.B8MM12"/>
    <dbReference type="GeneID" id="8108419"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_097800"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="InParanoid" id="B8MM12"/>
    <dbReference type="OMA" id="ASHAHRM"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="PhylomeDB" id="B8MM12"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED13524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="342" mass="37735" checksum="0A64B5C98068797C" modified="2009-03-03" version="1">MESFQKNFSVENIPNLTGKVVIVTGGATGIGKEAVKQLLKHNAKVYVASRSKGKFEQLCNHLESIDPHMTAGLHFLELNLSDARSCISAAKQFSELEERLDVLIANAALSVVPETLSSDGIEIQFGTNYFGHFVFTHNLLDLIQRTSEQYDEARIVVVASHAHVMYKPVQPDKIDFEGLRTEGSKTIQSLAEVQASLQRYARSKLANILFARHLHTHFQETGYTNILVNCLNPGTVGAAPGTDSAALPPVFKFLNSSIVRLMSIPPEDGALTILLLATDPEIKDKSLSGRYFDVGPLAGKFYYGYSWDATDSKLSDLAKDKKLSERLWDWSVRTQASIDTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMM8</accession>
    <name>B8MMM8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_100270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486020.1">
        <property type="nucleotide sequence ID" value="XM_002485975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMM8"/>
    <dbReference type="STRING" id="441959.B8MMM8"/>
    <dbReference type="GeneID" id="8105470"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_100270"/>
    <dbReference type="eggNOG" id="KOG1680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_1"/>
    <dbReference type="InParanoid" id="B8MMM8"/>
    <dbReference type="OMA" id="VGRAFCT"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="PhylomeDB" id="B8MMM8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000074">
        <property type="entry name" value="Enoyl-CoA hydratase (AFU_orthologue AFUA_2G10650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF152">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G03410)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED13782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="276" mass="30113" checksum="E1F409383B4B15C4" modified="2009-03-03" version="1">MSIYFPDRSKTLQYDNFYVSFPQGNVLQITLNRPEKLNCINKATSLEIQKIWDYFDKDESLWVGIITGSGRAFCTGADLREWNEMNKAGVVSSMDAPGLAGIPRRSGRKPIIAAVNGICMGGGFEMIANCDMVLASSTAVFSLPEVKRGIVPVAGCLPRLTRTIGLQRTMDLVLTGRNVTARTLYEWGLVSRVIDSDSDVVKAAVQVAQEMCKNSPDALIIARQGIRMSWEIGSVEEAVSALAAESYPSLVAGPNFAEGIEAFVDKRPPAWINSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMS9</accession>
    <name>B8MMS9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongator complex protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_100770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486073.1">
        <property type="nucleotide sequence ID" value="XM_002486028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMS9"/>
    <dbReference type="GeneID" id="8097961"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_100770"/>
    <dbReference type="eggNOG" id="ENOG502QSI3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059771_0_0_1"/>
    <dbReference type="InParanoid" id="B8MMS9"/>
    <dbReference type="OMA" id="LYFIQRD"/>
    <dbReference type="OrthoDB" id="9995306at2759"/>
    <dbReference type="PhylomeDB" id="B8MMS9"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19495">
        <property type="entry name" value="Elp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018627">
        <property type="entry name" value="ELP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184:SF6">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="124"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED13835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="40080" checksum="BD81F504CF34825F" modified="2009-03-03" version="1">MPSQPPIPHILSPYLTHSTRSAQSLTLITSVLAATSNWLLLRYLHSVLSATALSEEDGYNETIESGPGRQKRRRRARRVVLVSFLREWMFWRGEGKRLGLDLQRFVDGDRFRYVDGLSGLFDRPQQEQGSVRPMTGGVMGSGRSIPMRGAIDSTRPTTSSIPTSPQSKNPTPQQKQKQLLLSGQGITALNQLENDILAVIKSITKSDIMSGNEEHAEDDILLILDQPDLILATTPDINENDISEWIMGLQQHVHSTVITTSADSPLIHNANTYTPDAGNIVTPLEKNHSAFVVGLAHRASMVLQLRTLDTGAAKDVSGVLRMSRGGGYETQRAEEDEDDVTEKEVLYFVQRDGGVRVFGRGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8MN96</accession>
    <name>B8MN96_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_107520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486783.1">
        <property type="nucleotide sequence ID" value="XM_002486738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MN96"/>
    <dbReference type="STRING" id="441959.B8MN96"/>
    <dbReference type="GeneID" id="8106781"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_107520"/>
    <dbReference type="eggNOG" id="ENOG502RQI6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_26_1_1"/>
    <dbReference type="InParanoid" id="B8MN96"/>
    <dbReference type="OMA" id="TANAWPN"/>
    <dbReference type="PhylomeDB" id="B8MN96"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED14545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="15263" checksum="F0489982A97B8F89" modified="2009-03-03" version="1">MLPSTLAAADFTAFQRTIPSSDIVIFSDGSRLIDGRAGGGYIGFQAHHQFLRSSLSYGHEKEVFDTEAEAALAGAQAAITYPTAQFATNLWICLDNLEVATRLLSPSTGSSQEVFESFRTLAAAWPLRERLPHTKSGSIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8MND8</accession>
    <name>B8MND8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_102580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486265.1">
        <property type="nucleotide sequence ID" value="XM_002486220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MND8"/>
    <dbReference type="GeneID" id="8100834"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_102580"/>
    <dbReference type="HOGENOM" id="CLU_425245_0_0_1"/>
    <dbReference type="InParanoid" id="B8MND8"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="PhylomeDB" id="B8MND8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="631" mass="69734" checksum="F6169A51A55CC360" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MP63</accession>
    <name>B8MP63_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_105140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486540.1">
        <property type="nucleotide sequence ID" value="XM_002486495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MP63"/>
    <dbReference type="STRING" id="441959.B8MP63"/>
    <dbReference type="GeneID" id="8098735"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_105140"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_4_1"/>
    <dbReference type="InParanoid" id="B8MP63"/>
    <dbReference type="OMA" id="ADRCERS"/>
    <dbReference type="OrthoDB" id="4215944at2759"/>
    <dbReference type="PhylomeDB" id="B8MP63"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED14302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="171" mass="18508" checksum="6165BE75D6E494F3" modified="2009-03-03" version="1">MPSYFGHFIHRQWVLNVPKPTASFASKVAIVTGGNSGLGKESVKHLVRLGASKVIIACRSKSKGEQAKLEILSALRCSADVLEAFVERANKLDRLDVLLNNAGVSTVKYKLSYGTEQAVGVSVIGTILLAIQLVPKLKETARAFGVTPHMTFTQSALYRLAKYPENPGARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPM3</accession>
    <name>B8MPM3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRAL/TRIO domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_106720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486700.1">
        <property type="nucleotide sequence ID" value="XM_002486655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPM3"/>
    <dbReference type="STRING" id="441959.B8MPM3"/>
    <dbReference type="GeneID" id="8103572"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_106720"/>
    <dbReference type="eggNOG" id="KOG1471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014001_4_0_1"/>
    <dbReference type="InParanoid" id="B8MPM3"/>
    <dbReference type="OMA" id="QFRREKD"/>
    <dbReference type="OrthoDB" id="30289at2759"/>
    <dbReference type="PhylomeDB" id="B8MPM3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF20">
        <property type="entry name" value="CRAL_TRIO DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G00680)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="85"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="351" mass="39610" checksum="F46AEEECF3D7D2E8" modified="2009-03-03" version="1">MMATDNTAVLSKFNGLCAEHGLLDRRDGMEESDRADGITDATTLLRFLKANRMDVSAALKQFREATKFHCTKNVTQLYDLINVDDFEDTRKLYPHWTGRRDSRGLPIFMIDVAHLDQEAISHWRETTEISSHDSCADINNTRPDMAQRACVLHDYITRFVFPLCSAMHDRPQSPEPVSRSVYLIDASSLGFKQAWDLRDFAREITWILSTCYPETIDRIHVCNAPTYFSQMWNILKKFVDPVTAEKIVVLKSVDVYPVLNQSIHHDDIPTQFGGGFDFSNGMLPNLCPAIQYTLNWSDPSSTTLPPGPIKWKENGDDRIAIATGTVDGVQRAIKVASLVGCDEKCPEALFS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-02-08" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPW2</accession>
    <name>ATP25_TALSN</name>
    <protein>
        <recommendedName>
            <fullName>ATPase synthesis protein 25, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">atp25</name>
        <name type="ORF">TSTA_053660</name>
    </gene>
    <organism>
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable mitochondrial mRNA stabilization factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP25 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486963.1">
        <property type="nucleotide sequence ID" value="XM_002486918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPW2"/>
    <dbReference type="SMR" id="B8MPW2"/>
    <dbReference type="STRING" id="441959.B8MPW2"/>
    <dbReference type="GeneID" id="8098317"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_053660"/>
    <dbReference type="eggNOG" id="ENOG502S5IB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016140_0_0_1"/>
    <dbReference type="InParanoid" id="B8MPW2"/>
    <dbReference type="OMA" id="CLSSWVP"/>
    <dbReference type="OrthoDB" id="107372at2759"/>
    <dbReference type="PhylomeDB" id="B8MPW2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140053">
        <property type="term" value="P:mitochondrial gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000044">
        <property type="entry name" value="ATPase synthesis protein 25, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040152">
        <property type="entry name" value="Atp25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28087">
        <property type="entry name" value="ATPASE SYNTHESIS PROTEIN 25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28087:SF1">
        <property type="entry name" value="ATPASE SYNTHESIS PROTEIN 25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000404487" description="ATPase synthesis protein 25, mitochondrial">
        <location>
            <begin position="61"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="286"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="338"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="680" mass="76017" checksum="1C6DB43F07906085" modified="2009-03-03" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPY9</accession>
    <name>B8MPY9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_053910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486990.1">
        <property type="nucleotide sequence ID" value="XM_002486945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPY9"/>
    <dbReference type="GeneID" id="8100331"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_053910"/>
    <dbReference type="eggNOG" id="ENOG502TAVW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2086399_0_0_1"/>
    <dbReference type="InParanoid" id="B8MPY9"/>
    <dbReference type="OrthoDB" id="4226581at2759"/>
    <dbReference type="PhylomeDB" id="B8MPY9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED12879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="117" mass="13790" checksum="65D7D02339C0D07A" modified="2009-03-03" version="1">MDLRNTLEPFALQSCLFQFEHPGFGLKRVLQVKDKHFYNLNGNDEELRRGEIMICLLEEISGQLRRPRYFTHMIAPGPQHARVIKAYFDGNNIVMRPTKLYDLRHKDSEALTTLTQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQI5</accession>
    <name>B8MQI5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">fumarate reductase (NADH)</fullName>
            <ecNumber evidence="7">1.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NADH-dependent fumarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_058750</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="7"/>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487498.1">
        <property type="nucleotide sequence ID" value="XM_002487453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQI5"/>
    <dbReference type="FunCoup" id="B8MQI5">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MQI5"/>
    <dbReference type="GeneID" id="8106477"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_058750"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011398_4_5_1"/>
    <dbReference type="InParanoid" id="B8MQI5"/>
    <dbReference type="OMA" id="EDLWVVV"/>
    <dbReference type="OrthoDB" id="10252157at2759"/>
    <dbReference type="PhylomeDB" id="B8MQI5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000007">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF1">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="10">
        <location>
            <begin position="544"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="493"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="509"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED13387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="628" mass="68106" checksum="3DF174D76B17866C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQR6</accession>
    <name>B8MQR6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_052360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486824.1">
        <property type="nucleotide sequence ID" value="XM_002486779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQR6"/>
    <dbReference type="GeneID" id="8098185"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_052360"/>
    <dbReference type="HOGENOM" id="CLU_1961061_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQR6"/>
    <dbReference type="OrthoDB" id="4526357at2759"/>
    <dbReference type="PhylomeDB" id="B8MQR6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED12713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="128" mass="13834" checksum="0BDFD25B12E693F5" modified="2009-03-03" version="1">MSDKPERVFSGSRRRVPWDRTKTSVRLLEASECAKDWAAQGILDTLLARPLTRLNAPGNTMARKGSGTDGPLQTALLESTFAATTRASEGQKIFSPIAAFLDKHRSQTAGLAPHLLRALTTLSDDLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQU3</accession>
    <name>B8MQU3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Monocarboxylate transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_052960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486889.1">
        <property type="nucleotide sequence ID" value="XM_002486844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQU3"/>
    <dbReference type="GeneID" id="8098245"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_052960"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_1_1"/>
    <dbReference type="InParanoid" id="B8MQU3"/>
    <dbReference type="OMA" id="TQAFLMF"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="PhylomeDB" id="B8MQU3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="43"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED12778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="434" mass="45956" checksum="ED89C16AD322D996" modified="2009-03-03" version="1">MEQANIFELPDPVSREAGGDAEKSSHITTSSPPAKSAPAENWFAWLQVLGAFSLNLNTWGLMNAFGVFQTFYQLDLLSSKSSADISWIGSTQSFLMFLVSVIAGPIVDAGHLKSLLALGSLLTILGMFMTSLCSTYWQVLLAQAVTMGLGFGCLYVPAPTIVSQYFHARTALAMGASSAGSALGGIIYPIIFTHLQPSIGFGWATRIIAFIILATLIPPLVLMKARSPPTSNYRLLDTSAFKDTPYILLNLGLVFGFMGFYIIFYYIQLYALQETSISSLVASYLLVIINAGSLPGRLIPGYYADRIGSINVQTTVALVGAILTFCLIANKNSAGLIVYSVLYGFSAGAFMGLPAAGVVNLTSDKSRIGTRLGMTLACVGCGVLVSSPIAGAILNGKGGWVGLVVWCGVLLTASCIAMAASRVCKVGWRAGRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQU5</accession>
    <name>B8MQU5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="1">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_052980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.2.9" evidence="1"/>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486891.1">
        <property type="nucleotide sequence ID" value="XM_002486846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQU5"/>
    <dbReference type="FunCoup" id="B8MQU5">
        <property type="interactions" value="276"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MQU5"/>
    <dbReference type="GeneID" id="8098247"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_052980"/>
    <dbReference type="eggNOG" id="KOG3082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033347_0_1_1"/>
    <dbReference type="InParanoid" id="B8MQU5"/>
    <dbReference type="OMA" id="LPTHEID"/>
    <dbReference type="OrthoDB" id="10268103at2759"/>
    <dbReference type="PhylomeDB" id="B8MQU5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138:SF5">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="3">
        <location>
            <begin position="36"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED12780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="261" mass="28601" checksum="91529E3314CE1C92" modified="2009-03-03" version="1">MSTYMYSALLILRTQARCNRANGRRWYSDKPIDPLRILFCGSDEFSIASLKALHAEQLQAPQSIKSIDVVCRPGKRVGRGLKQIREVPIKSTASELGLRIHELDTFRGWTPPDGPIDLIVAVSFGLFVPSRLLTAAKYGGVNVHPSLLPDLRGPAPLHHTLLSGKTTTGITLQTLHHKHFDQGMILDQTPAPGITIPNPDSCTVPELLGLLAPKGAEMLVNGIRHRVFVPPLKGVKSQFKESDAKDLTHAAKITPQDSHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRA0</accession>
    <name>B8MRA0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-1,3-glucan synthase</fullName>
            <ecNumber evidence="2">2.4.1.183</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_055010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[(1-&gt;3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19749"/>
            <dbReference type="Rhea" id="RHEA-COMP:11150"/>
            <dbReference type="Rhea" id="RHEA-COMP:11151"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28100"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.183" evidence="2"/>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487105.1">
        <property type="nucleotide sequence ID" value="XM_002487060.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MRA0"/>
    <dbReference type="GeneID" id="8100507"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_055010"/>
    <dbReference type="eggNOG" id="ENOG502QQX3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000488_0_0_1"/>
    <dbReference type="InParanoid" id="B8MRA0"/>
    <dbReference type="OMA" id="FLWYWGS"/>
    <dbReference type="OrthoDB" id="512920at2759"/>
    <dbReference type="PhylomeDB" id="B8MRA0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047657">
        <property type="term" value="F:alpha-1,3-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070600">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11323">
        <property type="entry name" value="AmyAc_AGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000058">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000052">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058659">
        <property type="entry name" value="Mok11-13/Ags1-like_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058656">
        <property type="entry name" value="Mok11-13/Ags1-like_GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058657">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058658">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058655">
        <property type="entry name" value="Mok11-14/Ags1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058654">
        <property type="entry name" value="Mok11-14/Ags1-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182:SF2">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26127">
        <property type="entry name" value="12TM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26122">
        <property type="entry name" value="CBM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26108">
        <property type="entry name" value="GH_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26114">
        <property type="entry name" value="Ig_2_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26111">
        <property type="entry name" value="Ig_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002875316" description="alpha-1,3-glucan synthase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="2393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1080"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1967"/>
            <end position="1989"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2001"/>
            <end position="2018"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2025"/>
            <end position="2048"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2133"/>
            <end position="2159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2180"/>
            <end position="2197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2217"/>
            <end position="2240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2247"/>
            <end position="2266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2291"/>
            <end position="2311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2318"/>
            <end position="2337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2365"/>
            <end position="2385"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="10">
        <location>
            <begin position="69"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1723"/>
            <end position="1743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1760"/>
            <end position="1793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1920"/>
            <end position="1946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1723"/>
            <end position="1736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1762"/>
            <end position="1793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED12994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="2393" mass="269324" checksum="AC72505758EA7F8F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRE0</accession>
    <name>B8MRE0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Molybdenum cofactor biosynthesis protein Gephyrin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_055390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>adenylyl-molybdopterin + molybdate = Mo-molybdopterin + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>molybdopterin + ATP + H(+) = adenylyl-molybdopterin + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:31331"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the MoaB/Mog family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487146.1">
        <property type="nucleotide sequence ID" value="XM_002487101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRE0"/>
    <dbReference type="STRING" id="441959.B8MRE0"/>
    <dbReference type="GeneID" id="8102232"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_055390"/>
    <dbReference type="eggNOG" id="KOG2371">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010186_2_2_1"/>
    <dbReference type="InParanoid" id="B8MRE0"/>
    <dbReference type="OMA" id="ESPYPMI"/>
    <dbReference type="OrthoDB" id="4349954at2759"/>
    <dbReference type="PhylomeDB" id="B8MRE0"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061598">
        <property type="term" value="F:molybdopterin adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.190.11:FF:000002">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.980.10:FF:000011">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="entry name" value="MoeA, C-terminal, domain IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.10">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.190.11">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192:SF5">
        <property type="entry name" value="GEPHYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="MOLYBDOPTERIN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="MoeA C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="MoeA N-terminal region -like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01079">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="7">
        <location>
            <begin position="9"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="MoaB/Mog" evidence="7">
        <location>
            <begin position="440"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="189"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="555"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED13035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="718" mass="75764" checksum="941578C7C9904CA9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSL8</accession>
    <name>B8MSL8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pogo transposable element, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_003980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488000.1">
        <property type="nucleotide sequence ID" value="XM_002487955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSL8"/>
    <dbReference type="STRING" id="441959.B8MSL8"/>
    <dbReference type="GeneID" id="8100110"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_003980"/>
    <dbReference type="eggNOG" id="KOG3105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_4_0_1"/>
    <dbReference type="InParanoid" id="B8MSL8"/>
    <dbReference type="OrthoDB" id="4457643at2759"/>
    <dbReference type="PhylomeDB" id="B8MSL8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="5"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="419"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="348"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED12346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="500" mass="57653" checksum="812A435105B4E115" modified="2009-03-03" version="1">MAKFDQFVKPHVLTQNEEESLLKWILDLDKRGLPPRPSLVQDMADLLLSQNGNKHVSERWVYRFVDRHPEVKLRFSRRYNYERAKCEDIKIIREHFNRVQEVIQEYGILSEDIYNFDETGFAMGLCASAKVITGSDRYGRPYLLQPGNREWVTAIEAVNSTGWALPSYVIFKATTYYQQGWFETLPQDWRLDISKNGWTTDEIGIRWLQKHFIPHTTSRTKGRYRMLILDGHGSHLTPQFDQICTENNIIPVCMPPHSSHLLQPLDVSCFAVLKRQYGRLVEQRVRLGFNHIDKYDFLTAFPEPRAMAYKAENVQNGFKATGLVPYNPDHVYEKLTVQLRTPTPPPSRSSNSQSSCQQTPQNPRQFNRQTATIKKRINDRTIGPFEVVDQAINRLSKAYEMSRNELLIIQKEVHDLRAANEKEKKKRKRSRAQISHEGSLTAQEAQELIGSRNEASQPIPTAPVESEPQTSQPRLRAPPKCSGCGIIGHKINRCPNRTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSU4</accession>
    <name>B8MSU4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Efflux pump antibiotic resistance protein, putative</fullName>
        </submittedName>
    </protein>
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        </source>
    </evidence>
    <sequence length="335" mass="37427" checksum="50EFA4EC589D843C" modified="2009-03-03" version="1">MPAFTCGCRQGATKRVGPTNRISGNLNSIRGFTSSRTTIATLDDVRLLSSLTCPHDKFHDACPALLSSTYVVSVNRQKIELFWERHPRRLMLYPEQSMGKRPLTRTASVASGSSCPGGRRPGPPPKRTFVPSTEDPIDHGRNFTNDSKEENIYYGDISPEDAMAQDAGYEADVEIVRPYAIEEPDEETDQTPTSTTTPKLLESTEQWQKELLNSLRGLYCDSDSTDTPPLVRHKRGRKRKTDFSMTAYPDFHSPPQPVRDWDADMGGGNILLSPKRRRRKSARSGEDIGVSHGSLLSSEYASTTSSPPYLSPINHENERPVLKRELSAKDRMDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTU2</accession>
    <name>B8MTU2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Phosphatidyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_005220</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488139.1">
        <property type="nucleotide sequence ID" value="XM_002488094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTU2"/>
    <dbReference type="FunCoup" id="B8MTU2">
        <property type="interactions" value="372"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MTU2"/>
    <dbReference type="GeneID" id="8104506"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_005220"/>
    <dbReference type="eggNOG" id="KOG1617">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051314_0_0_1"/>
    <dbReference type="InParanoid" id="B8MTU2"/>
    <dbReference type="OrthoDB" id="10020554at2759"/>
    <dbReference type="PhylomeDB" id="B8MTU2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043337">
        <property type="term" value="F:cardiolipin synthase (CMP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000017">
        <property type="entry name" value="Phosphatidyl synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF60">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE (CMP-FORMING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED12485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="397" mass="43863" checksum="389B343F65185BB5" modified="2009-03-03" version="1">MIDIKSRAKLNQAYFGFNGQEKSFRGSFDASTTSVHTLEISLPSDNLLLACQRVSRTPSRRQMRLFTPLKSTISTACASHHGMLSAVLRRRQLLSTRSSGVYSAFRQRRVVHTIFSNPLVGNTDGWRCNNTNPFLQPRVVTLNQKRRNGSTNSPPDKPEKELKLKPKSKLLSRLPVPVHENIYTVPNILTFSRLLAAPAVGYLLVHNHHTAALSLFAYAGITDLIDGYIARRYNLQTVVGTIIDPAADKLLMTISVVCLALNGWMPAWLAVLILGRDVGLSISAIYYRWISLPPPKTMARYWDFSLPSAEVKPTAISKVNTALQLLLVGSSIALPVLPESLAGAWGLYNGLVGLQLLVAATTVWSGLSYVFSKDAVKILSDKEIQQRIARASKNDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTW2</accession>
    <name>B8MTW2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_006060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488230.1">
        <property type="nucleotide sequence ID" value="XM_002488185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTW2"/>
    <dbReference type="FunCoup" id="B8MTW2">
        <property type="interactions" value="503"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MTW2"/>
    <dbReference type="GeneID" id="8105579"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_006060"/>
    <dbReference type="eggNOG" id="KOG3497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143122_2_1_1"/>
    <dbReference type="InParanoid" id="B8MTW2"/>
    <dbReference type="OMA" id="YCCRRMF"/>
    <dbReference type="OrthoDB" id="10258858at2759"/>
    <dbReference type="PhylomeDB" id="B8MTW2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00250">
        <property type="entry name" value="RNApol_arch_Rpo10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003089">
        <property type="entry name" value="PRK04016.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005653">
        <property type="entry name" value="RNA_pol_N/8_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED12576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="74" mass="8569" checksum="A2EB9684C34CFF3F" modified="2009-03-03" version="1">MIIPVRCFSCGKVVGDLWERYLQLLDDGVPDGDAMDQLGCKRYCCRRMVMTHVDLIEKLLRYNSSEREKAKTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MU26</accession>
    <name>B8MU26_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF1716 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_006780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488313.1">
        <property type="nucleotide sequence ID" value="XM_002488268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MU26"/>
    <dbReference type="STRING" id="441959.B8MU26"/>
    <dbReference type="GeneID" id="8105363"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_006780"/>
    <dbReference type="eggNOG" id="KOG2734">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017098_0_0_1"/>
    <dbReference type="InParanoid" id="B8MU26"/>
    <dbReference type="OMA" id="TDWREQE"/>
    <dbReference type="OrthoDB" id="1898821at2759"/>
    <dbReference type="PhylomeDB" id="B8MU26"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000354">
        <property type="entry name" value="DUF1716 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039678">
        <property type="entry name" value="CTNNBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013180">
        <property type="entry name" value="CTNNBL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978:SF0">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1 NUCLEAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08216">
        <property type="entry name" value="CTNNBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01156">
        <property type="entry name" value="DUF1716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta-catenin-like protein 1 N-terminal" evidence="7">
        <location>
            <begin position="96"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED12659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="596" mass="66643" checksum="5EBAA123E7DEBF8F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUK2</accession>
    <name>B8MUK2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposable element tc3 transposase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_108560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488426.1">
        <property type="nucleotide sequence ID" value="XM_002488381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUK2"/>
    <dbReference type="STRING" id="441959.B8MUK2"/>
    <dbReference type="GeneID" id="8103112"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_108560"/>
    <dbReference type="eggNOG" id="ENOG502SCE0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033666_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUK2"/>
    <dbReference type="OMA" id="EAYWENI"/>
    <dbReference type="OrthoDB" id="4737581at2759"/>
    <dbReference type="PhylomeDB" id="B8MUK2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052338">
        <property type="entry name" value="Transposase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022:SF119">
        <property type="entry name" value="TC1-LIKE TRANSPOSASE DDE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022">
        <property type="entry name" value="TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="1">
        <location>
            <begin position="78"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="2">
        <location>
            <begin position="222"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED11670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="344" mass="40373" checksum="E85D90F3189E0EF2" modified="2009-03-03" version="1">MPPPQRRTARRELDPCMRARICELHTEAHWGYKRIHRAHPEIPISTIRNTIKKEQERINQRSMPRTGPPEKLTDEDKQKLIELTIQYPHIKYMELRNAIDNKVTIRTIQGMFQKIHKRKWKQRKRPEILPLNAQKRLAWALRYEAYTPREWQRILWSDECTVERGKGGQLIWTWHSLSEQLMEHDMFWGGFKFDERSPLVPLTPDGSSAGGGITATVIKQLYMEQLPGLLREGDIFMQDNAPVHRAHIIRNLLRELGLDLMEWPPYSPDLNPIENIWAIMKTIIHNDHPELQNAPDNEQTLLALIQAAKEAWGSIEARVLKNLSNTMPNRVRAVIEADGWYTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUN3</accession>
    <name>B8MUN3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_108830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488457.1">
        <property type="nucleotide sequence ID" value="XM_002488412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUN3"/>
    <dbReference type="GeneID" id="8103139"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_108830"/>
    <dbReference type="HOGENOM" id="CLU_1866465_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUN3"/>
    <dbReference type="OrthoDB" id="197419at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="137" mass="15526" checksum="47317CEBD570B30A" modified="2009-03-03" version="1">MQAYTLVTEEDMINGIYSNINSCQALPLHGPLKYYQGAYGETALYAAASSGNYSAVFWFFGLPEITHGQYGLSDQRTGAFSRLEPATAFQLEPRNREQERRVASPLDPVYMENTEPQEADKRLRQTKRQRKIGTPDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUZ1</accession>
    <name>B8MUZ1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_110120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488588.1">
        <property type="nucleotide sequence ID" value="XM_002488543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUZ1"/>
    <dbReference type="STRING" id="441959.B8MUZ1"/>
    <dbReference type="GeneID" id="8107244"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_110120"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131109_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUZ1"/>
    <dbReference type="OrthoDB" id="4307211at2759"/>
    <dbReference type="PhylomeDB" id="B8MUZ1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="18996" checksum="90E8A85FF0855575" modified="2009-03-03" version="1">MASTAALEVEAYVLPTNLRLKQRAQIVAARLSTLPEDHPGRSGPRFPLAETLRTMDLTRLQALETIDPTPPPPWQTPAFVEIDIELDWDKAKDKASARQKASGIIVFSDALGQQNALGAAAVTLVGQQELVTILSDSMSALQAISNTWNKSGQRIIQAVRQAAQELKARGIPLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8MV01</accession>
    <name>B8MV01_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_110700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488647.1">
        <property type="nucleotide sequence ID" value="XM_002488602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MV01"/>
    <dbReference type="STRING" id="441959.B8MV01"/>
    <dbReference type="GeneID" id="8101442"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_110700"/>
    <dbReference type="HOGENOM" id="CLU_013929_4_0_1"/>
    <dbReference type="InParanoid" id="B8MV01"/>
    <dbReference type="OMA" id="WERNIIC"/>
    <dbReference type="OrthoDB" id="71166at2759"/>
    <dbReference type="PhylomeDB" id="B8MV01"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="27"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED11891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="356" mass="40618" checksum="96388BDEBD9E2A43" modified="2009-03-03" version="1">MGLCATAKVITGSDRYTWPKLLQPGDREWVTAIEAVNSTGWALPSYIIFKAKKYMWLGWFEDLPANWIINISDNGWTTDKIGLEWLKLHFIPLTNDRSIGKYQMLILDGHRSHLTAEFDCICTKNNISPPLDVGYFAILKRYYGQLVEQRMRLGFNHIDKFDFLTAFPKARTMAYKAQNIWNSFAATGLVPFNPDRVYQQLTVQLKTPTPPPSRSSDTQPSCLQTPQNARQFKRQMTTIGKQISQHTENSSEVFYKAITQASKAYETTMNDLLLSRKENHDLRTAHEKEKQKRQKSKKQVSNEQGISTEEAQVLIQDQIEASQAVTTVPAEPELPVSHPPVRCQFRCSGCGIKERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MV35</accession>
    <name>B8MV35_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_109300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488507.1">
        <property type="nucleotide sequence ID" value="XM_002488462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MV35"/>
    <dbReference type="GeneID" id="8107162"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109300"/>
    <dbReference type="HOGENOM" id="CLU_1397172_0_0_1"/>
    <dbReference type="InParanoid" id="B8MV35"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="PhylomeDB" id="B8MV35"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED11751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="195" mass="22595" checksum="74AC828FF61507D8" modified="2009-03-03" version="1">MVSRDRRAKIKPKGTLSSVSCPVCEQTFPRRNDWKRHVKPHYVEKIWTCPLCPKTTTKIGKSKERFNRPDLLRSHLRRSTEHYEMTKEAIEEIISSQTPTKTELKPSECPRCNRRFDSLELLIGHFIRNPLQRIQPRRTVKQRNPKTLGGPSITGTRTEELRIIYEYGLVPLRRKGLETIAVSKGAAKLKGLLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTW8</accession>
    <name>B8LTW8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_071940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341185.1">
        <property type="nucleotide sequence ID" value="XM_002341144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTW8"/>
    <dbReference type="FunCoup" id="B8LTW8">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LTW8"/>
    <dbReference type="GeneID" id="8103909"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_071940"/>
    <dbReference type="eggNOG" id="ENOG502S4DK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042191_0_0_1"/>
    <dbReference type="InParanoid" id="B8LTW8"/>
    <dbReference type="OMA" id="GITWLEW"/>
    <dbReference type="OrthoDB" id="5552842at2759"/>
    <dbReference type="PhylomeDB" id="B8LTW8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000402">
        <property type="term" value="F:crossed form four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16963">
        <property type="entry name" value="CCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039197">
        <property type="entry name" value="Mrs1/Cce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015242">
        <property type="entry name" value="Ydc2_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28072">
        <property type="entry name" value="CRUCIFORM CUTTING ENDONUCLEASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28072:SF1">
        <property type="entry name" value="CRUCIFORM CUTTING ENDONUCLEASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09159">
        <property type="entry name" value="Ydc2-catalyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED23798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="411" mass="45891" checksum="1B94507F7FC1E9D6" modified="2009-03-03" version="1">MRLALPNLSKLPSTGVETYLTSLKATQLKNLARETGIPSSGRKDELRHRISEELLTSILLHENKNHSTSEHKSKTKERKKSGKELSILSIDMGIQNLAFAHLIVRPLGEHAPGTGAGVDRGLIMLNAWHRINVQELRSCAPATQTTDTEIRNDEIEEESIPQTETTTNKNFEPDSLSYNAYVLLSSLLQAYKPTHILIERQRFRSGGQSAVLEWSLRVGVFEGMLHAVLCTMREVSRLLHDTHSDIYGLDGVVDGLKVYAISPARIKQFWDEGKSESLLDNEEEGRKGKGQNQRGVKTFKMDIVGDLLSASTKTGKSLSCWDLAVNTDKGEKGLGVSDVVDAYLRRWDPQAVDSQPTGLKGRKKSMSATTEKAHKIDKMDDLADCLLQGVTWLEWQARRARIVRGEFLIHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B8LU18</accession>
    <name>B8LU18_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_072410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341235.1">
        <property type="nucleotide sequence ID" value="XM_002341194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LU18"/>
    <dbReference type="GeneID" id="8109445"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_072410"/>
    <dbReference type="HOGENOM" id="CLU_2135212_0_0_1"/>
    <dbReference type="InParanoid" id="B8LU18"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED23848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="113" mass="12184" checksum="A5845D543449AF7D" modified="2009-03-03" version="1">MRISEATAHEAFTERKMYVTGDYPIIAQSPNGESVITGNADLVVCYKSGIWPLTSMSERTTDTYQGPAQAVTYMVGAHQKSVSLGPSDATETTAYGIVSGIELQFMKLNENVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUD4</accession>
    <name>B8LUD4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_071100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341094.1">
        <property type="nucleotide sequence ID" value="XM_002341053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUD4"/>
    <dbReference type="GeneID" id="8107616"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_071100"/>
    <dbReference type="eggNOG" id="ENOG502SJI1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094639_0_0_1"/>
    <dbReference type="InParanoid" id="B8LUD4"/>
    <dbReference type="OMA" id="GRYEDDC"/>
    <dbReference type="OrthoDB" id="5332384at2759"/>
    <dbReference type="PhylomeDB" id="B8LUD4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877230" evidence="1">
        <location>
            <begin position="28"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="184" mass="19819" checksum="35EDD1BAD0692050" modified="2009-03-03" version="1">MHSSTSTSILATTALTLLLSLPNLISACSVQGDVTTTFYGYPDNSPPGASIAYTQCGRSVAGGTGTYDDPLTFASAEGEFQICDVIYAPYLKKYLRFEDECDQCTSDWQNDGTWHIDVWTGSSSQDGGQNQIDCEDALTPDSQSIILNPDSGLEVDTTPLYDPDSQTCNTGNTYTGYDTSEYCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUM6</accession>
    <name>B8LUM6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_072730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341270.1">
        <property type="nucleotide sequence ID" value="XM_002341229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUM6"/>
    <dbReference type="STRING" id="441959.B8LUM6"/>
    <dbReference type="GeneID" id="8100165"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_072730"/>
    <dbReference type="eggNOG" id="ENOG502S89B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074184_0_0_1"/>
    <dbReference type="InParanoid" id="B8LUM6"/>
    <dbReference type="OMA" id="WHDEWML"/>
    <dbReference type="OrthoDB" id="4850648at2759"/>
    <dbReference type="PhylomeDB" id="B8LUM6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37827:SF1">
        <property type="entry name" value="HNH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37827">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="29364" checksum="297AEE0C5AE6DA13" modified="2009-03-03" version="1">MSDGGNNFEVFRECVSGVIVQKSQGGRKNSGKRRLKGKKRGDITKTSKDEQSSGGLEKQDPEELAEFIDFIVSEVFHALPETVQTLSYSKIQNDASLASRYSDATELTDSDMETLTATIPVSVSESLSVYGILPESMDITAAFLRPVLTDYITSVTAAPPAWATTKTEACEICERDWIPLSYHHLIPREVHTKALKRGWHEEFMLNSVAWLCRACHNFVHKMASNEELAREYYTIDRILERDDVQDWAKWVGRVRWKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUY9</accession>
    <name>B8LUY9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Endo-beta-1,4-mannanase F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_061010</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Has endoglucanase activity on substrates containing beta-1,4 glycosidic bonds, like in carboxymethylcellulose (CMC), hydroxyethylcellulose (HEC) and beta-glucan. Involved in the degradation of complex natural cellulosic substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002339997.1">
        <property type="nucleotide sequence ID" value="XM_002339956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUY9"/>
    <dbReference type="STRING" id="441959.B8LUY9"/>
    <dbReference type="GeneID" id="8101269"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_061010"/>
    <dbReference type="eggNOG" id="ENOG502QXN4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029718_0_1_1"/>
    <dbReference type="InParanoid" id="B8LUY9"/>
    <dbReference type="OMA" id="FRMERLI"/>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="PhylomeDB" id="B8LUY9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142:SF1">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002874485" description="cellulase" evidence="11">
        <location>
            <begin position="24"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="12">
        <location>
            <begin position="23"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED22610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="394" mass="42557" checksum="A29677B500BAB309" modified="2009-03-03" version="1">MTPRPTIVAIASFAVLAVTFVQAQQSGYGQCGGANWTGATSCVSGWTCTFLNDYYSQCLPSSTTLTTSSHSTTSTTSSTATSTPTNTNGGKLKWFGVDESCAEFGTAMPGTWGVDYTFANTATIGEFINQGFNIFRIPFAMERMARGSVGATLDNAYLTNYSVAVDYITSNGAYAVLDAHNYGRYNGNIITDTSAFKTFWSNMATAFKNNSKVIFDTNNEYHDMDESLVFDLNQAAIDGIRGSGATTQYIFAEGNSWTGAWTWNTTNDSLKNLKDPENLLIYEMHQYLDSDGSGTSATCVSSTIGVERIEGATAWLKANGKIGVLGEYAGGPNSVCQEAVTGMLDHLTANNDVWFGAVWWAAGPWWPSSTWSSIEPPSGQAYVYYDNILQAYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVC5</accession>
    <name>B8LVC5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AAA family ATPase/60S ribosome export protein Rix7, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_073340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341331.1">
        <property type="nucleotide sequence ID" value="XM_002341290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVC5"/>
    <dbReference type="FunCoup" id="B8LVC5">
        <property type="interactions" value="995"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LVC5"/>
    <dbReference type="GeneID" id="8105602"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_073340"/>
    <dbReference type="eggNOG" id="KOG0733">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_8_3_1"/>
    <dbReference type="InParanoid" id="B8LVC5"/>
    <dbReference type="OMA" id="GLWSTHR"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="PhylomeDB" id="B8LVC5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19518">
        <property type="entry name" value="RecA-like_NVL_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000081">
        <property type="entry name" value="AAA family ATPase/60S ribosome export protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000018">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000365">
        <property type="entry name" value="Ribosome biogenesis ATPase RIX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="207"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="513"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED23944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="740" mass="81298" checksum="FCC6C602D7897BE7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVD3</accession>
    <name>B8LVD3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CTP:phosphocholine cytidylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phosphorylcholine transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_073410</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="9"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341339.1">
        <property type="nucleotide sequence ID" value="XM_002341298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVD3"/>
    <dbReference type="STRING" id="441959.B8LVD3"/>
    <dbReference type="GeneID" id="8109472"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_073410"/>
    <dbReference type="eggNOG" id="KOG2804">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034585_5_1_1"/>
    <dbReference type="InParanoid" id="B8LVD3"/>
    <dbReference type="OMA" id="IPDCPWI"/>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="PhylomeDB" id="B8LVD3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042564">
        <property type="term" value="C:NLS-dependent protein nuclear import complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000147">
        <property type="entry name" value="Cholinephosphate cytidylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="167"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="358"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="438"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED23952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="475" mass="52684" checksum="3CC776EBB72CB18D" modified="2009-03-03" version="1">MSSPSSSSGKRKRTASIAHNNNHNNNTIPNTLKPAELLQPSSRDASGEEGDDSTAPTDERPLSRHKKTPSLTIDPNAHPSKRARTRSGADTTSKSENHHEDPGEPSETTDASADIETRSKRKASTQVVAANGDVDDKDAFVPLRAGLQDPVGYHTNPPPTGRAVRVYADGVFDLFHLGHMRQLEQAKKAFPEVYLIVGVTGDEETHKRKGLTVLSGAERAETVRHCKWVDEVIPNCPWIVTPEFLEEHRIDYVAHDDLPYQADEGDDIYAPIKAQGKFLVTQRTEGVSTTGIITKIVRDYDKYIARQFKRGASRQELNVSWLKKNELEIKRHVNELRESIRNNWNMTGQELSKEFRQFWGNSRSNSPSRTSIKNGVDMHSPRSSFSISKTHLSRGLDSPTGRPESPGPAGRNEDFATGYSLGLIGGVRAWMSRTRTPYLSGPTSPVASDDDRDAVSTFESGDERRRPSLLRGDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVK8</accession>
    <name>B8LVK8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_074100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341414.1">
        <property type="nucleotide sequence ID" value="XM_002341373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVK8"/>
    <dbReference type="STRING" id="441959.B8LVK8"/>
    <dbReference type="GeneID" id="8105652"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_074100"/>
    <dbReference type="eggNOG" id="ENOG502SH94">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014819_3_2_1"/>
    <dbReference type="InParanoid" id="B8LVK8"/>
    <dbReference type="OMA" id="KWNGRFQ"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="PhylomeDB" id="B8LVK8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF8">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED24027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="514" mass="56299" checksum="917E42BFC0D2E145" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVL4</accession>
    <name>B8LVL4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_075180</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341531.1">
        <property type="nucleotide sequence ID" value="XM_002341490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVL4"/>
    <dbReference type="STRING" id="441959.B8LVL4"/>
    <dbReference type="GeneID" id="8106195"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_075180"/>
    <dbReference type="eggNOG" id="KOG1964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8LVL4"/>
    <dbReference type="OrthoDB" id="3098at2759"/>
    <dbReference type="PhylomeDB" id="B8LVL4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3450.20:FF:000003">
        <property type="entry name" value="Nuclear pore complex protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="834"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="834"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED24144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1046" mass="118975" checksum="01E3A6C511D7D53E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVR1</accession>
    <name>B8LVR1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_075620</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341578.1">
        <property type="nucleotide sequence ID" value="XM_002341537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVR1"/>
    <dbReference type="STRING" id="441959.B8LVR1"/>
    <dbReference type="GeneID" id="8106201"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_075620"/>
    <dbReference type="eggNOG" id="KOG4711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001788_0_1_1"/>
    <dbReference type="InParanoid" id="B8LVR1"/>
    <dbReference type="OMA" id="FYSCMHT"/>
    <dbReference type="OrthoDB" id="2274698at2759"/>
    <dbReference type="PhylomeDB" id="B8LVR1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF4">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="658"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="688"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="710"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="736"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="804"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="7">
        <location>
            <begin position="74"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="8">
        <location>
            <begin position="684"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="606"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="945"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1108"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="958"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1122"/>
            <end position="1133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED24191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1147" mass="129575" checksum="24A11E5A5DA1224C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVY2</accession>
    <name>B8LVY2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable E3 ubiquitin ligase complex SCF subunit sconB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Sulfur controller B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Sulfur metabolite repression control protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_077150</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the SCF(sconB) E3 ubiquitin ligase complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341735.1">
        <property type="nucleotide sequence ID" value="XM_002341694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVY2"/>
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        <property type="entry name" value="WD40_rpt"/>
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        <property type="entry name" value="UBIQUITIN-BINDING SDF UBIQUITIN LIGASE COMPLEX SUBUNIT"/>
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        <property type="match status" value="4"/>
    </dbReference>
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        <location>
            <begin position="95"/>
            <end position="141"/>
        </location>
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            <begin position="305"/>
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        </location>
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        <location>
            <begin position="346"/>
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        </location>
    </feature>
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        <location>
            <begin position="391"/>
            <end position="430"/>
        </location>
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        <location>
            <begin position="479"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="519"/>
            <end position="558"/>
        </location>
    </feature>
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        <location>
            <begin position="165"/>
            <end position="257"/>
        </location>
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        <location>
            <begin position="722"/>
            <end position="768"/>
        </location>
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        <location>
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            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="733"/>
            <end position="752"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00002730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011725"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00015819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00030034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00032113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED24348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="853" mass="95273" checksum="00739198EE9115FC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8LW32</accession>
    <name>B8LW32_TALSN</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">TSTA_074380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24060.1"/>
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    <dbReference type="GeneID" id="8107641"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075090_1_0_1"/>
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    </dbReference>
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        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED24060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="243" mass="26647" checksum="B96533112C0BE04D" modified="2009-03-03" version="1">MASLSSRSLSRLALHSRIGLNPITTVRSAVLRRYTSIIPDGSRTSSYTRPFSLQKSFRPPVTGTNLQHRGYADLKASGGKTEADLIVEELQELYDNAKDELEIATDSTNSATIYAASDRESARELLDQLLYVYKVYTEMTRSSSAGGPDLVSPLSQNEQSTTPNAQQANADRLDANAAKEASNPILDGTGEALSGNSYVGITPNYDPEYISVEVKEEVKERVGQRIRELKSAVERLEEMASHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8LX05</accession>
    <name>B8LX05_TALSN</name>
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        <recommendedName>
            <fullName evidence="1">Rhamnogalacturonase A/B/Epimerase-like pectate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_079930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002341984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LX05"/>
    <dbReference type="STRING" id="441959.B8LX05"/>
    <dbReference type="GeneID" id="8106609"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_079930"/>
    <dbReference type="HOGENOM" id="CLU_2499401_0_0_1"/>
    <dbReference type="InParanoid" id="B8LX05"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="PhylomeDB" id="B8LX05"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED24638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="86" mass="8825" checksum="737D9662EDBB896F" modified="2009-03-03" version="1">MQQQGSSPYAPAGYQVFRNVKDYGAKGDGVTDDTAAINKAISDGDRCGADCGLSTVYPAIVFFPGDPRVCGPGESVASAEGHPARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8LY48</accession>
    <name>B8LY48_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_067330</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340680.1">
        <property type="nucleotide sequence ID" value="XM_002340639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LY48"/>
    <dbReference type="FunCoup" id="B8LY48">
        <property type="interactions" value="247"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LY48"/>
    <dbReference type="GeneID" id="8101015"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_067330"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    </feature>
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        </location>
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        <location>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
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</entry>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="725" mass="84191" checksum="EBC55F237233565E" modified="2009-03-03" version="1"> </sequence>
</entry>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </feature>
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            <end position="173"/>
        </location>
    </feature>
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        <location>
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            <end position="399"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF26053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED22839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="653" mass="71173" checksum="DE79A98B17DA8FB0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYD3</accession>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Trichocomaceae</taxon>
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    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    </comment>
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    <dbReference type="GeneID" id="8109411"/>
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    <dbReference type="eggNOG" id="KOG3855">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_14_2_1"/>
    <dbReference type="InParanoid" id="B8LYD3"/>
    <dbReference type="OMA" id="ADLSEYW"/>
    <dbReference type="OrthoDB" id="2690153at2759"/>
    <dbReference type="PhylomeDB" id="B8LYD3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21274">
        <property type="entry name" value="Rng_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="13"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED22862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="560" mass="61276" checksum="BA699EE13EA17692" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYN8</accession>
    <name>B8LYN8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Ubiquitin-like protein ATG12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_068230</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate functions as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Forms a conjugate with ATG5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Preautophagosomal structure membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ATG12 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340783.1">
        <property type="nucleotide sequence ID" value="XM_002340742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYN8"/>
    <dbReference type="STRING" id="441959.B8LYN8"/>
    <dbReference type="GeneID" id="8108625"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_068230"/>
    <dbReference type="eggNOG" id="KOG3439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106795_1_2_1"/>
    <dbReference type="InParanoid" id="B8LYN8"/>
    <dbReference type="OMA" id="DLPMNMS"/>
    <dbReference type="OrthoDB" id="10003551at2759"/>
    <dbReference type="PhylomeDB" id="B8LYN8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01612">
        <property type="entry name" value="Ubl_ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000148">
        <property type="entry name" value="Ubiquitin-like protein ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007242">
        <property type="entry name" value="Atg12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385">
        <property type="entry name" value="AUTOPHAGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04110">
        <property type="entry name" value="APG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6 12" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <keyword evidence="7 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED23396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="172" mass="18664" checksum="E57AFB9F0B08D2DA" modified="2009-03-03" version="1">MDSPSPSDSSRRDSPQPALSSPALAQRPKPTGRSDSSAAGNTAIPDEDHGVDIPLTMSASVVLTGLPHDTHRALADAEAIDVGKVTVRFQPLPSAPILRKTVFKISASQKFETVVNFLRKKLDCKDTDTVFCYINSVFAPSLDEGIGGLHRCFKNETDDQLWVQYSMTPFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZB4</accession>
    <name>B8LZB4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosidase 2 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_089030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478630.1">
        <property type="nucleotide sequence ID" value="XM_002478585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZB4"/>
    <dbReference type="FunCoup" id="B8LZB4">
        <property type="interactions" value="543"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LZB4"/>
    <dbReference type="GeneID" id="8104870"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_089030"/>
    <dbReference type="eggNOG" id="KOG2397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016834_2_1_1"/>
    <dbReference type="InParanoid" id="B8LZB4"/>
    <dbReference type="OMA" id="YENGQHC"/>
    <dbReference type="OrthoDB" id="28322at2759"/>
    <dbReference type="PhylomeDB" id="B8LZB4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036607">
        <property type="entry name" value="PRKCSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028146">
        <property type="entry name" value="PRKCSH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF1">
        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12999">
        <property type="entry name" value="PRKCSH-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13015">
        <property type="entry name" value="PRKCSH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877335" description="Glucosidase 2 subunit beta" evidence="6">
        <location>
            <begin position="22"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="7">
        <location>
            <begin position="442"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="174"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="251"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED21667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="568" mass="63269" checksum="DC31C38C5AC2FD3F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZL7</accession>
    <name>B8LZL7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_096890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479403.1">
        <property type="nucleotide sequence ID" value="XM_002479358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZL7"/>
    <dbReference type="STRING" id="441959.B8LZL7"/>
    <dbReference type="GeneID" id="8103532"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_096890"/>
    <dbReference type="HOGENOM" id="CLU_2428558_0_0_1"/>
    <dbReference type="InParanoid" id="B8LZL7"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="PhylomeDB" id="B8LZL7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED22440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="9534" checksum="D4C10DA4A807D9F9" modified="2009-03-03" version="1">MARSTIRVAIVGGGMAGGSLLHAFIPHLHLDVHIFESASAFRQAGMAIGVARNALDTLDLLGAVPVRHVRFMLAQGEGIGNMIDQANDDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8M043</accession>
    <name>B8M043_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">UPF0023 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_083720</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478103.1">
        <property type="nucleotide sequence ID" value="XM_002478058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M043"/>
    <dbReference type="FunCoup" id="B8M043">
        <property type="interactions" value="1017"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M043"/>
    <dbReference type="GeneID" id="8101465"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_083720"/>
    <dbReference type="eggNOG" id="KOG2917">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043216_1_0_1"/>
    <dbReference type="InParanoid" id="B8M043"/>
    <dbReference type="OMA" id="AVNPQMD"/>
    <dbReference type="OrthoDB" id="10253092at2759"/>
    <dbReference type="PhylomeDB" id="B8M043"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990932">
        <property type="term" value="F:5.8S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046928">
        <property type="entry name" value="SDO1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20268">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="9">
        <location>
            <begin position="14"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="10">
        <location>
            <begin position="110"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS C-terminal" evidence="11">
        <location>
            <begin position="266"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="142"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="219"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED21140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="332" mass="36717" checksum="99D13AC595E9B225" modified="2009-03-03" version="1">MPINQPSNQIKFTNVSIVRLKKGKKRFELACYKNKLLEYRSGVEKDLDNVLQIHTVFLSVNKAQTAPSAELAKAFGAGVSQDEIIQEILRKGEVQVGERERKDILERVQKEVVDIVSGRLVDPTTKRVYTPTMIEKALDQLSAASGHQQQQQNGEETPEHGATTGEQRKPLWKGVSATKSAKSQALEAMKALIAWQPIPVMRARMRLRVTCPVSLLKQSVKGASSGAPKEESKPSKGNNKKGQKGKGKKHQDSEDEDETEDQEASPKAPSNVKEKILSFIESVESQEIVGEEWETVGFAEPGAFKGLSEFVTSETRGRGRVEVLDMAVTHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0G2</accession>
    <name>B8M0G2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF659 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_084900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478222.1">
        <property type="nucleotide sequence ID" value="XM_002478177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0G2"/>
    <dbReference type="STRING" id="441959.B8M0G2"/>
    <dbReference type="GeneID" id="8106096"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_084900"/>
    <dbReference type="HOGENOM" id="CLU_1563919_0_0_1"/>
    <dbReference type="InParanoid" id="B8M0G2"/>
    <dbReference type="OMA" id="LAMIGHW"/>
    <dbReference type="OrthoDB" id="2976890at2759"/>
    <dbReference type="PhylomeDB" id="B8M0G2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47501:SF5">
        <property type="entry name" value="HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47501">
        <property type="entry name" value="TRANSPOSASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED21259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="19857" checksum="26BB139881A9730D" modified="2009-03-03" version="1">MYALYTSKNNLPILAMIGHWLTEDFFYKERVLEFIELHGIHSSENIAIAIQTTLSQLNLGEKLITITGDNASNNETMASELFHLLNSDWERSSQIHRTLTKFNELTLFVSKRKSQISLAIPVYYELHDLLCEGSESQWSFKELDPDIASALKEGLKKYMKYYTFMNESEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0I7</accession>
    <name>B8M0I7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_085150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478247.1">
        <property type="nucleotide sequence ID" value="XM_002478202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0I7"/>
    <dbReference type="GeneID" id="8106121"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_085150"/>
    <dbReference type="eggNOG" id="ENOG502SATA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124525_1_0_1"/>
    <dbReference type="InParanoid" id="B8M0I7"/>
    <dbReference type="OMA" id="SGMMMKL"/>
    <dbReference type="PhylomeDB" id="B8M0I7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="115" mass="12976" checksum="1422F5EC5FB4BD93" modified="2009-03-03" version="1">MFGRRTRTTRTTKPTLMTRLKGPNARHKTYKTEVTRHGHGSTTTTGATRRRRGYNHHTTTRTAPAHHHRRRPSLGDKISGAMMRLKGSLTGRPAEKAAGTRRMRGTDGRGSRRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1A1</accession>
    <name>B8M1A1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lysozyme</fullName>
            <ecNumber evidence="11">3.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_082760</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">This enzyme has both lysozyme (acetylmuramidase) and diacetylmuramidase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="11"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478006.1">
        <property type="nucleotide sequence ID" value="XM_002477961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1A1"/>
    <dbReference type="GeneID" id="8105154"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_082760"/>
    <dbReference type="eggNOG" id="ENOG502RYP2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044973_4_0_1"/>
    <dbReference type="InParanoid" id="B8M1A1"/>
    <dbReference type="OMA" id="TSWWTQC"/>
    <dbReference type="OrthoDB" id="6590422at2759"/>
    <dbReference type="PhylomeDB" id="B8M1A1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06412">
        <property type="entry name" value="GH25_CH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000060">
        <property type="entry name" value="Lysozyme M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008270">
        <property type="entry name" value="Glyco_hydro_25_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018077">
        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34135">
        <property type="entry name" value="LYSOZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34135:SF2">
        <property type="entry name" value="LYSOZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
        <property type="entry name" value="Glyco_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00953">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="6" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002874688" description="Lysozyme" evidence="12">
        <location>
            <begin position="21"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED21043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="227" mass="24021" checksum="C36D347497FA531E" modified="2009-03-03" version="1">MNAFVSTLAVSASLVGIAKATVQGFDISSYQPNVDFSSAYSSGARFVIIKATEGTTYTDSTFSSHYEGATNAGFIRGGYHFAHPDRSSGATQAQYFISHGGGWSGDGITLPGMLDIEYNPSGATCYGLSASEMVSWISDFVDTYHASEGVYPLIYTTNDWWTTCTGDSTAFSSTCPLVLARYASSPGTIPGGWGYETIWQNADSYAYGGDSDVFNGDLSQLKAIASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1N0</accession>
    <name>B8M1N0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UPF0052 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_093630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479080.1">
        <property type="nucleotide sequence ID" value="XM_002479035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1N0"/>
    <dbReference type="FunCoup" id="B8M1N0">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M1N0"/>
    <dbReference type="GeneID" id="8102607"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_093630"/>
    <dbReference type="eggNOG" id="ENOG502QUXN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019029_3_0_1"/>
    <dbReference type="InParanoid" id="B8M1N0"/>
    <dbReference type="OMA" id="IHLITPF"/>
    <dbReference type="OrthoDB" id="10267139at2759"/>
    <dbReference type="PhylomeDB" id="B8M1N0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07187">
        <property type="entry name" value="YvcK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="entry name" value="CofD-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240:SF0">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="CofD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED22117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="549" mass="58725" checksum="C8ACDB79DB265BD4" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2A3</accession>
    <name>B8M2A3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_088030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478530.1">
        <property type="nucleotide sequence ID" value="XM_002478485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2A3"/>
    <dbReference type="GeneID" id="8101095"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_088030"/>
    <dbReference type="HOGENOM" id="CLU_051551_1_0_1"/>
    <dbReference type="InParanoid" id="B8M2A3"/>
    <dbReference type="OrthoDB" id="4526357at2759"/>
    <dbReference type="PhylomeDB" id="B8M2A3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="200" mass="21531" checksum="DFC6234813A0BE19" modified="2009-03-03" version="1">MARKGPGTDGPLQIALLESMSASTTRASEGQKIFSPIATFLNKYRSQTISLAPHLLRALTTLSDDLILVVQQHFNAYISNILTTSILPALSPSPSSSPTSNSLPPSLPPSHPPSGLEQLTYATITQYTPVKSTPTTHSKAPIKKPMPLTGFALCPSSPEALLAFEAQKEIISTFFVNCQIERSSQWVSYRVVNVPVTAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2H5</accession>
    <name>B8M2H5_TALSN</name>
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        <recommendedName>
            <fullName evidence="8">Developmental and secondary metabolism regulator veA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Velvet complex subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_088750</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the velvet family. VeA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478602.1">
        <property type="nucleotide sequence ID" value="XM_002478557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2H5"/>
    <dbReference type="STRING" id="441959.B8M2H5"/>
    <dbReference type="GeneID" id="8106972"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_088750"/>
    <dbReference type="eggNOG" id="ENOG502QVY9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022491_2_0_1"/>
    <dbReference type="InParanoid" id="B8M2H5"/>
    <dbReference type="OMA" id="TDITFSY"/>
    <dbReference type="OrthoDB" id="5384689at2759"/>
    <dbReference type="PhylomeDB" id="B8M2H5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034250">
        <property type="term" value="P:positive regulation of amide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051176">
        <property type="term" value="P:positive regulation of sulfur metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043455">
        <property type="term" value="P:regulation of secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.3960:FF:000001">
        <property type="entry name" value="Sexual development activator VeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF14">
        <property type="entry name" value="DEVELOPMENTAL AND SECONDARY METABOLISM REGULATOR VEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="11">
        <location>
            <begin position="25"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="238"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="550"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED21639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="573" mass="62866" checksum="6635CDBAF9F2D3EF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2U0</accession>
    <name>B8M2U0_TALSN</name>
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        <submittedName>
            <fullName evidence="5">AMP binding domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_094410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479158.1">
        <property type="nucleotide sequence ID" value="XM_002479113.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B8M2U0">
        <property type="interactions" value="46"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M2U0"/>
    <dbReference type="GeneID" id="8103769"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_094410"/>
    <dbReference type="eggNOG" id="KOG3628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000737_0_0_1"/>
    <dbReference type="InParanoid" id="B8M2U0"/>
    <dbReference type="OMA" id="LVWTYWT"/>
    <dbReference type="OrthoDB" id="69964at2759"/>
    <dbReference type="PhylomeDB" id="B8M2U0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056881">
        <property type="entry name" value="Mug62_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754:SF32">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23024">
        <property type="entry name" value="AMP-dom_DIP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24919">
        <property type="entry name" value="Mug62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="240"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Meiotically up-regulated gene 62 protein-like alpha-beta" evidence="4">
        <location>
            <begin position="786"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="1000"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="1475"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1602"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1698"/>
            <end position="1840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1602"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1749"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1782"/>
            <end position="1809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED22195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1840" mass="204818" checksum="27DCFBB07247298E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8M391</accession>
    <name>B8M391_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-conjugating enzyme, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_095090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479226.1">
        <property type="nucleotide sequence ID" value="XM_002479181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M391"/>
    <dbReference type="STRING" id="441959.B8M391"/>
    <dbReference type="GeneID" id="8103839"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_095090"/>
    <dbReference type="eggNOG" id="KOG0429">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040072_0_0_1"/>
    <dbReference type="InParanoid" id="B8M391"/>
    <dbReference type="OMA" id="DGIWAKR"/>
    <dbReference type="OrthoDB" id="5596422at2759"/>
    <dbReference type="PhylomeDB" id="B8M391"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23814">
        <property type="entry name" value="UEV_AKTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="12"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED22263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="345" mass="37430" checksum="B618439922EFD8F8" modified="2009-03-03" version="1">MASSRLPNIPSLRKQQLFLEFRSLKHAPPAGVYVSITNPTDPTHWSGVIFIRKGPYASAILRFNIKFPPTYPELPPLITFTTDIFHPLIVPLTTYTFTTGSSNEAPVSATDEERLSPGAFSLRHGFPHWFGRARRTANNSAAGSRNVSGGSIPPATVTDQEANEQTQPDAGSSSPAPGNSIPQEGAEPTAESSLQETPKAPENNPHISKAPTANPFEKKDETVHVVTLLDYIRSTFDDEAVLDSLPLDAAGNPGAWHAWKAHRSGPGTPNKRGTPQTRLPGEWNWEGVWAKRVQSGIQASQSDAALFASTPRAETDSIRFLDLDPSVLNSVKEKLIAGLKEKESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3Q3</accession>
    <name>B8M3Q3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyrroline-5-carboxylate reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_038520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481080.1">
        <property type="nucleotide sequence ID" value="XM_002481035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3Q3"/>
    <dbReference type="STRING" id="441959.B8M3Q3"/>
    <dbReference type="GeneID" id="8107894"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_038520"/>
    <dbReference type="eggNOG" id="KOG3124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042344_1_0_1"/>
    <dbReference type="InParanoid" id="B8M3Q3"/>
    <dbReference type="OMA" id="ERITEWM"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="PhylomeDB" id="B8M3Q3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF0">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="3">
        <location>
            <begin position="7"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="4">
        <location>
            <begin position="208"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED20646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="328" mass="35036" checksum="F7F5149D0DE5D9F3" modified="2009-03-03" version="1">MRGGTTLAIIGCGQIGTSILEVLLTTLSQPCPNQQHNPLPILSMKLKPSRFIACVISQDSVSRLRTKFGHFARSSYPNVQISQGRVVEVVQQADIILLTLQASQGADLLSDPSLREHLAGKLLLSTCADLSVQQIEQLIYNDAIEEGGTVSERCFIVQAIPNTAAGVRQSATLISETVAGADTTLPPDFQSLTTWIFSSIGTVTYMPESLMNSASMISGLAPAFYTVALEGIAKEAIARGLSEPDALFLAAQALKGTAEMVLSKKEENKGLFALDEVRDQAIASSNGSGARGTLVLRQATVKDSFAEAMSQGMEKRDTEDCLLSVTWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8M422</accession>
    <name>B8M422_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aconitase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_039610</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481199.1">
        <property type="nucleotide sequence ID" value="XM_002481154.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M422"/>
    <dbReference type="GeneID" id="8109299"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_039610"/>
    <dbReference type="eggNOG" id="KOG0454">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_256911_0_0_1"/>
    <dbReference type="InParanoid" id="B8M422"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="PhylomeDB" id="B8M422"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170034">
        <property type="term" value="P:L-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170038">
        <property type="term" value="P:proteinogenic amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011827">
        <property type="entry name" value="LeuD_type2/HacB/DmdB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02087">
        <property type="entry name" value="LEUD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF2">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="8">
        <location>
            <begin position="207"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="9">
        <location>
            <begin position="673"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="10">
        <location>
            <begin position="941"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="834"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED20765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1362" mass="150668" checksum="8C7B0C4B1703DCB2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B8M428</accession>
    <name>B8M428_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS alpha-glucoside transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_039660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481205.1">
        <property type="nucleotide sequence ID" value="XM_002481160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M428"/>
    <dbReference type="GeneID" id="8109304"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_039660"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="InParanoid" id="B8M428"/>
    <dbReference type="OMA" id="TLAYIQH"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="PhylomeDB" id="B8M428"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF53">
        <property type="entry name" value="ALPHA-GLUCOSIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="58"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED20771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="555" mass="61867" checksum="BD5E019F07A054BE" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8M496</accession>
    <name>B8M496_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS peptide transporter Ptr2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_024210</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479525.1">
        <property type="nucleotide sequence ID" value="XM_002479480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M496"/>
    <dbReference type="FunCoup" id="B8M496">
        <property type="interactions" value="1113"/>
    </dbReference>
    <dbReference type="GeneID" id="8109603"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_024210"/>
    <dbReference type="eggNOG" id="KOG1237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004790_4_2_1"/>
    <dbReference type="InParanoid" id="B8M496"/>
    <dbReference type="OMA" id="WMHGAEG"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="PhylomeDB" id="B8M496"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17350">
        <property type="entry name" value="MFS_PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="506"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED19091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="582" mass="64317" checksum="4B42D5CC1C4614C7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4C7</accession>
    <name>B8M4C7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_024460</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479556.1">
        <property type="nucleotide sequence ID" value="XM_002479511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4C7"/>
    <dbReference type="STRING" id="441959.B8M4C7"/>
    <dbReference type="GeneID" id="8097977"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_024460"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010365_7_2_1"/>
    <dbReference type="InParanoid" id="B8M4C7"/>
    <dbReference type="OMA" id="LVFYIRH"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="PhylomeDB" id="B8M4C7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF23">
        <property type="entry name" value="FERRIC-CHELATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="298"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED19122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="632" mass="72350" checksum="6C58E999C72DA314" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4V5</accession>
    <name>B8M4V5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Metaphase-anaphase transition protein (Mlo2), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_026920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479824.1">
        <property type="nucleotide sequence ID" value="XM_002479779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4V5"/>
    <dbReference type="STRING" id="441959.B8M4V5"/>
    <dbReference type="GeneID" id="8098972"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_026920"/>
    <dbReference type="eggNOG" id="KOG2752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025221_1_0_1"/>
    <dbReference type="InParanoid" id="B8M4V5"/>
    <dbReference type="OMA" id="GAMVYNH"/>
    <dbReference type="OrthoDB" id="10262564at2759"/>
    <dbReference type="PhylomeDB" id="B8M4V5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19677">
        <property type="entry name" value="UBR-box_UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040204">
        <property type="entry name" value="UBR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047506">
        <property type="entry name" value="UBR7-like_UBR-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="6">
        <location>
            <begin position="61"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="4">
        <location>
            <begin position="61"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="291"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="395"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="493"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="325"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="397"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="502"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED19390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="523" mass="58146" checksum="7BCBF3A00E7C772E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5G1</accession>
    <name>B8M5G1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">S-(hydroxymethyl)glutathione dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.284</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_030340</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-nitrosoglutathione + NADH + H(+) = S-(hydroxysulfenamide)glutathione + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:78371"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:145544"/>
            <dbReference type="ChEBI" id="CHEBI:229723"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.284" evidence="12"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480201.1">
        <property type="nucleotide sequence ID" value="XM_002480156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5G1"/>
    <dbReference type="FunCoup" id="B8M5G1">
        <property type="interactions" value="750"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M5G1"/>
    <dbReference type="GeneID" id="8101713"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_030340"/>
    <dbReference type="eggNOG" id="KOG0022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_14_0_1"/>
    <dbReference type="InParanoid" id="B8M5G1"/>
    <dbReference type="OMA" id="IKGRSEM"/>
    <dbReference type="OrthoDB" id="417550at2759"/>
    <dbReference type="PhylomeDB" id="B8M5G1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033833">
        <property type="term" value="F:hydroxymethylfurfural reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106322">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106321">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080007">
        <property type="term" value="F:S-nitrosoglutathione reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000947">
        <property type="term" value="P:amino acid catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033859">
        <property type="term" value="P:furaldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000001">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02818">
        <property type="entry name" value="adh_III_F_hyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 12 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="20"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED19767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="380" mass="39991" checksum="233FE54CD0435301" modified="2009-03-03" version="1">MADTVGKTITCKAAIAWEAGQPLSVEDVEVAPPKAHEVRIQIFHTGVCHTDAYTLSGKDPEGAFPVILGHEGAGIVESVGEGVTNVKPGDTVIALYTPECGECKFCKSGKTNLCGKIRATQGRGVMPDGTSRFRARGKDILHFMGTSTFSQYTVVADISVVAVTDKAGTDKTCLLGCGITTGYGAAVVTAKVEEGSNVAVFGAGCVGLSVIQGALKNKAGKIIAVDVNDSKEAWARKFGATDFVNPTKLGNQSVQEKLIEMTDGGCDYTFDCTGNVGVMRAALEACHKGWGQSIVIGVAAAGQEISTRPFQLVTGRVWKGCAFGGIKGRSQLPSLVDDYLNGKLKVDEFITHRETLANINTAFEQMKAGDCIRCVVDVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5Q2</accession>
    <name>B8M5Q2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSTA_032050</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480380.1">
        <property type="nucleotide sequence ID" value="XM_002480335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5Q2"/>
    <dbReference type="FunCoup" id="B8M5Q2">
        <property type="interactions" value="827"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M5Q2"/>
    <dbReference type="GeneID" id="8099818"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_032050"/>
    <dbReference type="eggNOG" id="KOG0340">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_1_1"/>
    <dbReference type="InParanoid" id="B8M5Q2"/>
    <dbReference type="OMA" id="GMPYPKQ"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="PhylomeDB" id="B8M5Q2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17955">
        <property type="entry name" value="DEADc_DDX49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="139"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="350"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EED19946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="538" mass="59033" checksum="C0ED808E431B1CB0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5R2</accession>
    <name>B8M5R2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydroxybutyrate dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_032920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480473.1">
        <property type="nucleotide sequence ID" value="XM_002480428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5R2"/>
    <dbReference type="STRING" id="441959.B8M5R2"/>
    <dbReference type="GeneID" id="8105031"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_032920"/>
    <dbReference type="eggNOG" id="KOG1209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="InParanoid" id="B8M5R2"/>
    <dbReference type="OMA" id="WRGQMAG"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="PhylomeDB" id="B8M5R2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED20039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="275" mass="29510" checksum="5FCCEA27F053FCBD" modified="2009-03-03" version="1">MPQQSVLITGCSDDGIGYGLALTFQQRGYLVFATTRDAKKMSKLQDLPNVTLLALDVTEPSQIAAAAKVVSNQTGGTLDYLINNAGRNHFMPILDEDLNATRAIFETNVWGPVAVTQAFAPLLIKAKGNIVFITSISGYVNVPWMGSYAASKRSIEIIAETLRLELGPFNVGVLSIVTGAVKTQGQTYFGDFKLPSDSLYHSIEDTIAARAQGNDGTTRMNLMTYCDQVVTKITKGATGKFWCGDSAGAVKFGSSYLPTSIMDRGLVKGTGLDKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6D0</accession>
    <name>B8M6D0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_026160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479739.1">
        <property type="nucleotide sequence ID" value="XM_002479694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6D0"/>
    <dbReference type="STRING" id="441959.B8M6D0"/>
    <dbReference type="GeneID" id="8108028"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_026160"/>
    <dbReference type="eggNOG" id="ENOG502SHVM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_3_7_1"/>
    <dbReference type="InParanoid" id="B8M6D0"/>
    <dbReference type="OMA" id="QSACCCL"/>
    <dbReference type="OrthoDB" id="5417887at2759"/>
    <dbReference type="PhylomeDB" id="B8M6D0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF155">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="35"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED19305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="344" mass="38093" checksum="4A61E34032B8BD7F" modified="2009-03-03" version="1">MSSFNPDVDFNESRGYQINIIGWVFTGIAIATVGLKLFTRGHMAKNLGWDDFFIFFSMGLSIIATAFVSYSVTLGLGRHSAAVVAEHGMDGYALAAKWQIIAFRSFSFPNISIAILIHNLLDPNRFRSISLYAMAILQVVIAMISAVLVFVQCKPIAILWDPRLLSEGSCWSPDVFNDFTYWVSAYTTVTDIILAVVPVSAFWKLQMRTSTKVAVCTMMSLTLLSAVVTIVKATYLHLFTDHADPLYNVVTLVLWGLVEQNVVIVAACIPTLRPFFRTVFTKDSRSGTTSGGSEIYSGHAYKLSSNTAHATSKRPESESEIPLGNRDGIWQTREVMVESEEDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6H7</accession>
    <name>B8M6H7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_027360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479873.1">
        <property type="nucleotide sequence ID" value="XM_002479828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6H7"/>
    <dbReference type="STRING" id="441959.B8M6H7"/>
    <dbReference type="GeneID" id="8109655"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_027360"/>
    <dbReference type="eggNOG" id="ENOG502S55E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008206_0_0_1"/>
    <dbReference type="InParanoid" id="B8M6H7"/>
    <dbReference type="OMA" id="TMEKDDF"/>
    <dbReference type="OrthoDB" id="5354458at2759"/>
    <dbReference type="PhylomeDB" id="B8M6H7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056687">
        <property type="entry name" value="DUF7785"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057199">
        <property type="entry name" value="DUF7877"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25009">
        <property type="entry name" value="DUF7785"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF25289">
        <property type="entry name" value="DUF7877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7877" evidence="3">
        <location>
            <begin position="62"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7785" evidence="2">
        <location>
            <begin position="452"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="767"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="632"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED19439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="809" mass="88091" checksum="4DE560316A643A93" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-24" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6L1</accession>
    <name>RSSA_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">40S ribosomal protein S0</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">rps0</name>
        <name type="ORF">TSTA_027670</name>
    </gene>
    <organism>
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with rps21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479907.1">
        <property type="nucleotide sequence ID" value="XM_002479862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6L1"/>
    <dbReference type="SMR" id="B8M6L1"/>
    <dbReference type="FunCoup" id="B8M6L1">
        <property type="interactions" value="1265"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M6L1"/>
    <dbReference type="GeneID" id="8109686"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_027670"/>
    <dbReference type="eggNOG" id="KOG0830">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058171_0_1_1"/>
    <dbReference type="InParanoid" id="B8M6L1"/>
    <dbReference type="OMA" id="VKNFFEP"/>
    <dbReference type="OrthoDB" id="414863at2759"/>
    <dbReference type="PhylomeDB" id="B8M6L1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="40S ribosomal protein S0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
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        <property type="entry name" value="Ribosomal_uS2_C"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16122">
        <property type="entry name" value="40S_SA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000389291" description="Small ribosomal subunit protein uS2">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="290" mass="31241" checksum="42BCF60FDFD30DB8" modified="2009-03-03" version="1">MAPSNLPPVFNATSQDIEMLLAAQCHLGSKNLQVHMEPYLWKTRPDGINVINIGKTWEKIVLAARIIAAIDNPADVAVISARPYGQRAVLKFASHTGATAIAGRFTPGNFTNYITRSFKEPRLIIVTDPRTDAQAIKEASYVNIPVIALCDTDSPTEFVDVAIPTNNKGRHAIGLVWWLLAREVLRLRGTLATRETEWDVVVDLYFYRDPEAEETKEIADESKVPGAEEVGPAAIETGYVGDSWDAAAPGAAAPGSAFAAASATAGATWEAEAGGDWAAESAQPNPETKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B8M812</accession>
    <name>B8M812_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable E3 ubiquitin ligase complex SCF subunit sconB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Sulfur controller B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Sulfur metabolite repression control protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_032300</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SCF(sconB) E3 ubiquitin ligase complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480408.1">
        <property type="nucleotide sequence ID" value="XM_002480363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M812"/>
    <dbReference type="STRING" id="441959.B8M812"/>
    <dbReference type="GeneID" id="8099843"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_032300"/>
    <dbReference type="eggNOG" id="KOG0281">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_103_4_1"/>
    <dbReference type="InParanoid" id="B8M812"/>
    <dbReference type="OMA" id="KDISICV"/>
    <dbReference type="OrthoDB" id="19711at2759"/>
    <dbReference type="PhylomeDB" id="B8M812"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF745">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="11">
        <location>
            <begin position="250"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="354"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="441"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="482"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="522"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="562"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="604"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED19974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="690" mass="75824" checksum="7DA1E12E2C45F4F3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8Q4</accession>
    <name>B8M8Q4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2 transcription factor (Con7), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_037830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481001.1">
        <property type="nucleotide sequence ID" value="XM_002480956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8Q4"/>
    <dbReference type="STRING" id="441959.B8M8Q4"/>
    <dbReference type="GeneID" id="8102159"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_037830"/>
    <dbReference type="eggNOG" id="ENOG502S48N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030366_1_0_1"/>
    <dbReference type="InParanoid" id="B8M8Q4"/>
    <dbReference type="OMA" id="TSHMYSA"/>
    <dbReference type="OrthoDB" id="1939603at2759"/>
    <dbReference type="PhylomeDB" id="B8M8Q4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039327">
        <property type="entry name" value="CON7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167:SF3">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="96"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED20567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="248" mass="27688" checksum="24DC0E17E95DDB12" modified="2009-03-03" version="1">MAQATNPSIAASSPTYPPPYSPYQPQGHDMSQYQGHPPPQMYARPEWSHGYPHQQHPMQGPYSSPAPPTVYSFVPIPGAQQHKRPRRRYEEIERMYKCGWNGCEKAYGTLNHLNAHVTMQSHGNKRTPEEFKEIRKEWKARKKEEENQRKAAEERERQAAAQAQAQAGQVEGGAPPDPSQGGQPPSYAGGVRPQLPPIGYQPAENQVPGQYAPGGAGGMVYPQGNGQMYGNYPHSPYAQNNQVYQQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8W3</accession>
    <name>B8M8W3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_038330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481060.1">
        <property type="nucleotide sequence ID" value="XM_002481015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8W3"/>
    <dbReference type="STRING" id="441959.B8M8W3"/>
    <dbReference type="GeneID" id="8107875"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_038330"/>
    <dbReference type="HOGENOM" id="CLU_000384_6_3_1"/>
    <dbReference type="InParanoid" id="B8M8W3"/>
    <dbReference type="OMA" id="INVHRIF"/>
    <dbReference type="OrthoDB" id="4364638at2759"/>
    <dbReference type="PhylomeDB" id="B8M8W3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED20626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="190" mass="21529" checksum="FC11BA9138BD0483" modified="2009-03-03" version="1">MSFDWKKLVPPRKLTLNEKEAQAWIKRIQSVWEFARENMKIAQDRQALQANKKRRPPNFTVNDLVVVQKVGNSFELDLPEDINVHRIFSLDKLRLASSSELLAGQLEDPSPESQVNGNSEWVVELAWARSGSQVVSGGIFEERTARLEGFPRSISGKPGPPVRLKTWLEAAEEDKFVDDHPDDDIPVTNA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-10-14" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9H9</accession>
    <name>FAEB_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Feruloyl esterase B</fullName>
            <ecNumber evidence="7">3.1.1.73</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Ferulic acid esterase B</fullName>
            <shortName>FAE</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">faeB</name>
        <name type="ORF">TSTA_115370</name>
    </gene>
    <organism>
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="J. Biotechnol." volume="108" first="227" last="241">
            <title>The feruloyl esterase system of Talaromyces stipitatus: production of three discrete feruloyl esterases, including a novel enzyme, TsFaeC, with a broad substrate specificity.</title>
            <authorList>
                <person name="Garcia-Conesa M.T."/>
                <person name="Crepin V.F."/>
                <person name="Goldson A.J."/>
                <person name="Williamson G."/>
                <person name="Cummings N.J."/>
                <person name="Connerton I.F."/>
                <person name="Faulds C.B."/>
                <person name="Kroon P.A."/>
            </authorList>
            <dbReference type="PubMed" id="15006424"/>
            <dbReference type="DOI" id="10.1016/j.jbiotec.2003.12.003"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 19-56; 185-211 AND 266-295</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <source>
            <strain>ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Involved in degradation of plant cell walls. Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans as well as the feruloyl-galactose and feruloyl-arabinose ester bonds in pectin (By similarity). Active against methyl esters of caffeate (MCA), but not sinapate (MSA) (PubMed:15006424).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate esterase 1 (CE1) family. Feruloyl esterase type B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.73" evidence="7"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481731.1">
        <property type="nucleotide sequence ID" value="XM_002481686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9H9"/>
    <dbReference type="SMR" id="B8M9H9"/>
    <dbReference type="STRING" id="441959.B8M9H9"/>
    <dbReference type="ESTHER" id="talsn-faeb">
        <property type="family name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="B8M9H9">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="GeneID" id="8101347"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_115370"/>
    <dbReference type="eggNOG" id="ENOG502QTDU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027551_1_1_1"/>
    <dbReference type="InParanoid" id="B8M9H9"/>
    <dbReference type="OMA" id="VMLKFFG"/>
    <dbReference type="OrthoDB" id="2425929at2759"/>
    <dbReference type="PhylomeDB" id="B8M9H9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000203">
        <property type="entry name" value="Feruloyl esterase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050955">
        <property type="entry name" value="Plant_Biomass_Hydrol_Est"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01840">
        <property type="entry name" value="esterase_phb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037:SF3">
        <property type="entry name" value="FERULOYL ESTERASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0719">Serine esterase</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000433997" description="Feruloyl esterase B">
        <location>
            <begin position="19"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="5">
        <location>
            <begin position="322"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Catalytic" evidence="3">
        <location>
            <begin position="19"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Gly/Thr-rich linker" evidence="9">
        <location>
            <begin position="292"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="O42807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q4WBW4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="15006424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="8">
        <source>
            <dbReference type="PubMed" id="15006424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="9"/>
    <sequence length="358" mass="37584" checksum="47EBBB6321EF55E1" modified="2009-03-03" version="1" precursor="true">MAIPLVLLLAWLLPTVFAASLTQVSNFGDNPGSLQMYIYVPNNLASKPAIIVAMHPCGGSATQYYGMYDYHTPADQYGYILIYPSATRDLNCFDADTAASLTHNGGSDSLSIVNMVKYTISKYGADSSKVYMTGSSSGAIMTNVLAGTYPDVFAAGAAFSGMPFACLSGAGGADPAMSNQTCSRGQINHTPQEWAAYVHNAYPGYTGQYPRLQVWHGTADNVISYTDFNQEISQWTTVMGLSFTSNQTNTPLSGYTKMIYGDGSRFQAFSASGVGHFVPTDVSVVLDWFGITGGGGGNGGGSGSTTTTTSATTTSTGPTGGCTAAHWDQCGGNGYTGCTSCASPYTCQKVNDYYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9P0</accession>
    <name>B8M9P0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Succinate dehydrogenase cytochrome b560 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_118140</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome b560 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482034.1">
        <property type="nucleotide sequence ID" value="XM_002481989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9P0"/>
    <dbReference type="FunCoup" id="B8M9P0">
        <property type="interactions" value="365"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M9P0"/>
    <dbReference type="GeneID" id="8099738"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_118140"/>
    <dbReference type="eggNOG" id="KOG0449">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094691_0_2_1"/>
    <dbReference type="InParanoid" id="B8M9P0"/>
    <dbReference type="OMA" id="LTWMLSG"/>
    <dbReference type="OrthoDB" id="588261at2759"/>
    <dbReference type="PhylomeDB" id="B8M9P0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000008">
        <property type="entry name" value="Succinate dehydrogenase cytochrome b560 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01000">
        <property type="entry name" value="SDH_CYT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01001">
        <property type="entry name" value="SDH_CYT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED18042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="188" mass="20336" checksum="ED708C11E5D18473" modified="2009-03-03" version="1">MISQKVAQQSLRRLAIQSPSGLTLSMAKFATPAAIATGRYMQMRPTSTTPNTTDPTKILAQQRLKRPVSPHLSIYRPQITWYASGLHRITGSIASGGLYVFATAYLVAPVFGWHLESASIAAAFGALPFAAKFLVKLGLALPVTFHSFNGVRHLLWDTGRFLTNKQVIQTGWTVVGLSTISALALALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9P5</accession>
    <name>B8M9P5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MobA-like NTP transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_118170</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482039.1">
        <property type="nucleotide sequence ID" value="XM_002481994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9P5"/>
    <dbReference type="GeneID" id="8099741"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_118170"/>
    <dbReference type="eggNOG" id="ENOG502SR1X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_357216_0_0_1"/>
    <dbReference type="InParanoid" id="B8M9P5"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="PhylomeDB" id="B8M9P5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02503">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013482">
        <property type="entry name" value="Molybde_CF_guanTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MobA-like NTP transferase" evidence="9">
        <location>
            <begin position="574"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED18047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="785" mass="89168" checksum="B64BEA89BCC31F7F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9Q6</accession>
    <name>B8M9Q6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Terpene cyclase/mutase family member</fullName>
            <ecNumber evidence="7">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_118280</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="7"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482050.1">
        <property type="nucleotide sequence ID" value="XM_002482005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9Q6"/>
    <dbReference type="FunCoup" id="B8M9Q6">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M9Q6"/>
    <dbReference type="GeneID" id="8099752"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_118280"/>
    <dbReference type="eggNOG" id="KOG0497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009074_2_1_1"/>
    <dbReference type="InParanoid" id="B8M9Q6"/>
    <dbReference type="OMA" id="CWARQTI"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="PhylomeDB" id="B8M9Q6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000250">
        <property type="term" value="F:lanosterol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000003">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002365">
        <property type="entry name" value="Terpene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF76">
        <property type="entry name" value="TERPENE CYCLASE_MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01074">
        <property type="entry name" value="TERPENE_SYNTHASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Squalene cyclase N-terminal" evidence="9">
        <location>
            <begin position="94"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase C-terminal" evidence="8">
        <location>
            <begin position="400"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED18058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="739" mass="85134" checksum="2A03A2D42C097BA7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8MA92</accession>
    <name>B8MA92_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pectinesterase</fullName>
            <ecNumber evidence="3">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_123230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pectinesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="3"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482586.1">
        <property type="nucleotide sequence ID" value="XM_002482541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MA92"/>
    <dbReference type="STRING" id="441959.B8MA92"/>
    <dbReference type="GeneID" id="8108238"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_123230"/>
    <dbReference type="eggNOG" id="ENOG502R6WA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012243_2_0_1"/>
    <dbReference type="InParanoid" id="B8MA92"/>
    <dbReference type="OMA" id="TWAQANH"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="PhylomeDB" id="B8MA92"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000045">
        <property type="entry name" value="Pectin methylesterase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF137">
        <property type="entry name" value="PECTIN METHYL ESTERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011115820" description="pectinesterase" evidence="6">
        <location>
            <begin position="26"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="7">
        <location>
            <begin position="173"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED18594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="405" mass="44214" checksum="8C220FEF33FE7CB8" modified="2009-03-03" version="1">MKFLTKNNLWKTLVSISILIPTALSAPASRIDSRLPCQAGIISACPANTIIVSNDHSSPSSQHAHFTSIQSAILSLPHDNSSATILIRAGNYTEQLNITRPGPVTLLGETWDPLTATENQVTVYWSAANSNSRYMDNAFTSILTVAPTQNASLTGAGPTGWPVPADTPYGNSDFRAYNIDFRNVFSEYSAGPSLAVSVSYANAGFYYSGFYSYQDTVYIGKLGNAYFFNSIIAGQTDFLYGFGTAWLQACSLQLRSCGGGITAWKGTNTTYPNKFGVYIVDSTINAANASIAASIKGKCALGRPWNSLHRSIFARTYEDESIESSGYTHWVNGGAENYKLGVTLQAEFETYGPGWNETGRLSGGWDTILNRSIWEEYGEPAKVFQFGYESGGFGYVDWIDWTPWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBB6</accession>
    <name>B8MBB6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldo/keto reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_126150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482897.1">
        <property type="nucleotide sequence ID" value="XM_002482852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBB6"/>
    <dbReference type="STRING" id="441959.B8MBB6"/>
    <dbReference type="GeneID" id="8098127"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_126150"/>
    <dbReference type="eggNOG" id="ENOG502QU2T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1205468_0_0_1"/>
    <dbReference type="InParanoid" id="B8MBB6"/>
    <dbReference type="OMA" id="LRWASHH"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="PhylomeDB" id="B8MBB6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="37"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="135"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED18905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="230" mass="26622" checksum="968C812A8892BD1E" modified="2009-03-03" version="1">MGTWRLTPREYMASTRLLYLGQLKWQERGIVTGTKLNARGPYSHKKKALSLDFVDLWYLHAPDHNTPYEETLDAVNELYKAGYFKRFGISNYAAWEVAQICELCEKRDWKKPDVYQGVYHALHSHSPNDRGSNYFRRQYWNDAYFDALDVIRPVARKLGMTTAEAASRWASHHSMMKKEYGDAIIIGASNITQLEENLRSLEKGPLPEDMVRAFDEAWAIVKSACGPYFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBH9</accession>
    <name>B8MBH9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calponin homology domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_116330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481835.1">
        <property type="nucleotide sequence ID" value="XM_002481790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBH9"/>
    <dbReference type="STRING" id="441959.B8MBH9"/>
    <dbReference type="GeneID" id="8102025"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_116330"/>
    <dbReference type="eggNOG" id="KOG2046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024074_0_0_1"/>
    <dbReference type="InParanoid" id="B8MBH9"/>
    <dbReference type="OMA" id="HFLHACQ"/>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="PhylomeDB" id="B8MBH9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21210">
        <property type="entry name" value="CH_SCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF14">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="21"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="620"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED17843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="632" mass="71523" checksum="6B3EB80B6A6BDB4A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCA1</accession>
    <name>B8MCA1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF833 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_122770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482538.1">
        <property type="nucleotide sequence ID" value="XM_002482493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCA1"/>
    <dbReference type="FunCoup" id="B8MCA1">
        <property type="interactions" value="385"/>
    </dbReference>
    <dbReference type="GeneID" id="8097742"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_122770"/>
    <dbReference type="eggNOG" id="KOG2342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8MCA1"/>
    <dbReference type="OrthoDB" id="191601at2759"/>
    <dbReference type="PhylomeDB" id="B8MCA1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008551">
        <property type="entry name" value="TANGO2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985">
        <property type="entry name" value="SER/THR-RICH PROTEIN T10 IN DGCR REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985:SF8">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05742">
        <property type="entry name" value="TANGO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="351" mass="39272" checksum="839412435B0010ED" modified="2009-03-03" version="1">MCIALISTAHPAYELIIIDNRDEYLHRPTAPANWWQSPNTHVLGSRDLARPEQGTWMGVTRQGRVAVLTNYREASPVGSVSRGAIVNDFLTETGPAHLSGDRNGTGKEKEKEKEKENGGVRTTRAFVQDMINSQIAAKAGGFSLVCGRIGEPLAIISNRMSDNIDSVTWIASTRGETVGLSNTFLKDRTWPKIINGEILTREAIDSHIAAYPHTHHHPTGGEEEADLIQRLFQVLSTNTMPYLSNTEPVKEQYMNQLKESIFIPLLGDRPQFEAEEEHLAHMGLAGYMTGLYGTQKQTVLLVDFNGRVKYVERTLYDEHVHPIPLGEGDRVFEFVIEGWEAKSEQQNFSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCK2</accession>
    <name>B8MCK2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_125320</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482810.1">
        <property type="nucleotide sequence ID" value="XM_002482765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCK2"/>
    <dbReference type="FunCoup" id="B8MCK2">
        <property type="interactions" value="1110"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MCK2"/>
    <dbReference type="GeneID" id="8100311"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_125320"/>
    <dbReference type="eggNOG" id="KOG0546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_37_0_1"/>
    <dbReference type="InParanoid" id="B8MCK2"/>
    <dbReference type="OMA" id="EMEQNCN"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="PhylomeDB" id="B8MCK2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000029">
        <property type="entry name" value="peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000009">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="8 11" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="12">
        <location>
            <begin position="10"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="308"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED18818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="371" mass="41115" checksum="77A6201F77B1D5B3" modified="2009-03-03" version="1">MADKGRSRVYLDIEIDGRKEGRIALELFNDVVPKTAENFRALCTGEKGVGKQGKPLSFKGSIFHRVIKNFMIQGGDFTAFNGTGGESIYGEKFEDENFELKHDRPFLLSMANSGPATNGSQFFITTVETPHLDSKHVVFGQVINGKSLVRKIENMPTQADKPLRDVIIADCGELKGEDYDNADKKVVDATGDPYEDYPADHEGELNAQTAFEIASKLKELGNIAFKSGKTWVGLSKYQKALRYLNEVPEVDEKDPKELDAQMKVLRFTLHSNSALLANKLQHFPDGKTWAGYALDTADAANAKDADRAKAYYRRAVAEVGLKEEDDAIKDLEEALKLAPGDAAISNEITRVKKIIAEADKKQKEAARKFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDH1</accession>
    <name>B8MDH1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_117200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481926.1">
        <property type="nucleotide sequence ID" value="XM_002481881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MDH1"/>
    <dbReference type="GeneID" id="8105778"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_117200"/>
    <dbReference type="HOGENOM" id="CLU_2250980_0_0_1"/>
    <dbReference type="InParanoid" id="B8MDH1"/>
    <dbReference type="OMA" id="MTNMAGA"/>
    <dbReference type="OrthoDB" id="4498167at2759"/>
    <dbReference type="PhylomeDB" id="B8MDH1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="122" mass="13000" checksum="A2CF2024F833FC7A" modified="2009-03-03" version="1">MYWDMHSLPMAMNPAEGLPTEDISGRTSGIALLETTPGIDPRASVDDYNRVMLQYTQRQIEAFTQAGDNMLGRRNSGNSRSSGSSGQSNTSSMTNMAGAGSGLPPQQTRRDGSTQSPGSARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B8ME09</accession>
    <name>B8ME09_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_011950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483320.1">
        <property type="nucleotide sequence ID" value="XM_002483275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ME09"/>
    <dbReference type="GeneID" id="8104043"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_011950"/>
    <dbReference type="HOGENOM" id="CLU_1603848_0_0_1"/>
    <dbReference type="InParanoid" id="B8ME09"/>
    <dbReference type="PhylomeDB" id="B8ME09"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED16086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="166" mass="18762" checksum="FF32587874095412" modified="2009-03-03" version="1">MPTNSSRTNVSTAHGHTHCIEAAHRANALFRKAGNGAFYKKHVDQLILEYEGTRDDEELPEEFLSVVDKLILTDEYELEPQLQDASSNLFITMFFTTNNNDNANYGPLIIMELANRPTSHRIASLFSKTDSNVDIKPMKQPMRPRTLNRVICTSTRAAIPQKTLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8ME21</accession>
    <name>B8ME21_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_012070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483332.1">
        <property type="nucleotide sequence ID" value="XM_002483287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ME21"/>
    <dbReference type="GeneID" id="8104055"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_012070"/>
    <dbReference type="eggNOG" id="ENOG502QTNB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035756_0_0_1"/>
    <dbReference type="InParanoid" id="B8ME21"/>
    <dbReference type="OMA" id="WALRIHK"/>
    <dbReference type="OrthoDB" id="2566866at2759"/>
    <dbReference type="PhylomeDB" id="B8ME21"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF7">
        <property type="entry name" value="PA-PHOSPHATASE RELATED-FAMILY PROTEIN DDB_G0268928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="7">
        <location>
            <begin position="158"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="7">
        <location>
            <begin position="238"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="7">
        <location>
            <begin position="360"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED16098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="454" mass="51257" checksum="29CBB60186E58737" modified="2009-03-03" version="1">MGVGAVLEPLTVIVLLFGGTWINRRKENSYHSSRSASQYRLSSGSSSDSDVDEETGLQSTTDKDAYAESRPLSPSLLHHEAKWRTRTIALGPYKFKAHSPNTAIFRNRTLSRLLCRLPFLVECWYWALVYWTYQLGRAFTAMTLKDDTVDIARTHALQLVQIEKALGIFVETDIQKFFLARPMLMNVTNWVYSFIHIPGTIAFLVWLYYYTTTRNSLDDPRYSPLDHRINGSPGGPPLYAARRRTLAVCNLAAFVVFTLWPCMPPRLLSDEHVAGSVGDLARSYGFVDTVHGEKGAGSVWTENRFCNQYAAMPSLHFGYSLMIGLSIMTIPLSPQHRQSTSIRLPLVSNRINLRFGLPSWRRALCVALGVAYPLTILAAIIATANHFILDAVAGTLVCFFGWWANSILLNLLPLEDYFLWALRMHKPERQVMDVYEDTDEQDEPKVLAHASLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEF9</accession>
    <name>B8MEF9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Vacuolar ABC heavy metal transporter (Hmt1), putative</fullName>
            <ecNumber evidence="13">3.6.3.44</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_016630</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
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        <property type="protein sequence ID" value="EED16586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002483775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEF9"/>
    <dbReference type="STRING" id="441959.B8MEF9"/>
    <dbReference type="GeneID" id="8103636"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_016630"/>
    <dbReference type="eggNOG" id="KOG0056">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_6_1_1"/>
    <dbReference type="InParanoid" id="B8MEF9"/>
    <dbReference type="OMA" id="YYGAEHY"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="PhylomeDB" id="B8MEF9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044604">
        <property type="term" value="F:ABC-type phytochelatin transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036249">
        <property type="term" value="P:cadmium ion import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098849">
        <property type="term" value="P:cellular detoxification of cadmium ion"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071996">
        <property type="term" value="P:glutathione transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:phytochelatin 2 import into vacuole"/>
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        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
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        <property type="entry name" value="Vacuolar ABC heavy metal transporter (Hmt1)"/>
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        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF651">
        <property type="entry name" value="HEAVY METAL TOLERANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="560"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="326"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="647"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="889"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="889"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="905"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
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            <dbReference type="ARBA" id="ARBA00024363"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50929"/>
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    </evidence>
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            <dbReference type="EMBL" id="EED16586.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="922" mass="102839" checksum="10CF6BE0177E3CFA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEQ5</accession>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="228" mass="25345" checksum="47B8F6BBBBCE1C35" modified="2009-03-03" version="1">MATNMAGSPLYSYTVAPHLAAEFDVPFADFALAHPQYKFFVVAGFVFTKRSHSQPLPASASEYVKIKHLSSSATTSKSERGQNEPLMLIIQRALDDSYGGYWDFPGGSLEPHDQTILDGVAREVLEETGLHVSKIRDIVRIDTWIGSKSQMLVAGKFSFVVDVHEAADTVGWEEKIKLAPEEHVRWLWVSEEEIEKSAVRPGEDRIVPYAFVGVQGETAWEAFKTCPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEY9</accession>
    <name>B8MEY9_TALSN</name>
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        <submittedName>
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    </protein>
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    <organism evidence="1 2">
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="eggNOG" id="KOG0351">
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    <dbReference type="OMA" id="HENSQAG"/>
    <dbReference type="OrthoDB" id="4507197at2759"/>
    <dbReference type="PhylomeDB" id="B8MEY9"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED17272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="180" mass="21127" checksum="6C6981749790431C" modified="2009-03-03" version="1">MVDTFMIRGSQSLMQWMLDLRIYGLKIHYNTTTEGHVGWQNHDELLYKDLQFTMSEFRGMVDRTTREAWRILMEDLLQCSPEDAPAIPWDWLYDNPHIQRHPALRRKFMHADEQTFLEKLIACTQFTWGQPARAPELLSICHENSQAGGIRNVFIEDGLVVLVTKYHKGYQMSGDIKIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFG7</accession>
    <name>B8MFG7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_017750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483935.1">
        <property type="nucleotide sequence ID" value="XM_002483890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFG7"/>
    <dbReference type="STRING" id="441959.B8MFG7"/>
    <dbReference type="GeneID" id="8109032"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_017750"/>
    <dbReference type="eggNOG" id="KOG4169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_283729_0_0_1"/>
    <dbReference type="InParanoid" id="B8MFG7"/>
    <dbReference type="OMA" id="CKMARRT"/>
    <dbReference type="OrthoDB" id="4325529at2759"/>
    <dbReference type="PhylomeDB" id="B8MFG7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060963">
        <property type="term" value="P:positive regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.20">
        <property type="entry name" value="Centromere DNA-binding protein complex CBF3 subunit, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052146">
        <property type="entry name" value="HOT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038279">
        <property type="entry name" value="Ndc10_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031872">
        <property type="entry name" value="NDC10_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022210">
        <property type="entry name" value="TF_GCR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37784:SF2">
        <property type="entry name" value="HIGH-OSMOLARITY-INDUCED TRANSCRIPTION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37784">
        <property type="entry name" value="PROTEIN MSN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12550">
        <property type="entry name" value="GCR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16787">
        <property type="entry name" value="NDC10_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ndc10" evidence="4">
        <location>
            <begin position="126"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription activator GCR1-like" evidence="3">
        <location>
            <begin position="641"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="584"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="593"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED16701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1097" mass="124520" checksum="2CF3185B678CCECA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MG95</accession>
    <name>B8MG95_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenases/reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_013210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483449.1">
        <property type="nucleotide sequence ID" value="XM_002483404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MG95"/>
    <dbReference type="STRING" id="441959.B8MG95"/>
    <dbReference type="GeneID" id="8108197"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_013210"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_15_2_1"/>
    <dbReference type="InParanoid" id="B8MG95"/>
    <dbReference type="OMA" id="HTVLYLM"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="PhylomeDB" id="B8MG95"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051122">
        <property type="entry name" value="SDR_DHRS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057571">
        <property type="entry name" value="SDR_PhqE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477:SF1">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23441">
        <property type="entry name" value="SDR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED16215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="222" mass="24158" checksum="BECF6DB537350B40" modified="2009-03-03" version="1">MHKEFKWVNKLSGARLFIIGGTSGIGFGVAEASVEHGVSSRILSSSPKTRLEEANSKLNESYPNSSTDITARIVDHIVFTAGVALALKPFGEVDFESMKQTGTVRFFGALLVARYGHKNHAPSHKSSIILTSSVSSKKPISGWTVTRSYLSGLHGTMRGLAYDLKPIRVSLVTPGGVDTEMWNILDQKSRVTLIKGLKRQTTTGHVGTVESVAEAYLYRLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGA2</accession>
    <name>B8MGA2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pal1 cell morphology protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_013270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483456.1">
        <property type="nucleotide sequence ID" value="XM_002483411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGA2"/>
    <dbReference type="GeneID" id="8108202"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_013270"/>
    <dbReference type="eggNOG" id="ENOG502RB1B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087332_0_0_1"/>
    <dbReference type="InParanoid" id="B8MGA2"/>
    <dbReference type="OMA" id="CIRNHRP"/>
    <dbReference type="OrthoDB" id="5389892at2759"/>
    <dbReference type="PhylomeDB" id="B8MGA2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013226">
        <property type="entry name" value="Pal1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307:SF1">
        <property type="entry name" value="PAL1 CELL MORPHOLOGY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08316">
        <property type="entry name" value="Pal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="27714" checksum="E3DBE0A5670E483F" modified="2009-03-03" version="1">MDGPGNHFYPEDKNPFRNRKLNSMTLERRRSNSSPSTAIEESRNEFRETLKQQHDIQRRKTQRSSNSHNGKRHSHRRNRVNPDVIDQLDNVNFMQYHHEGPYDAVYPERNVCSKRSPLEAVKDSNEETLRATPMYMIIDSVQRHRPLDGVAFYPPGTTDKEGQTYEYTEGDNMMAEREGLFPRVPGEKITDEDLKNDPFYQQDNQRPPKRMGSLRKALTSLKGRSRRYSATTSGVVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGJ6</accession>
    <name>B8MGJ6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Polyadenylate-binding protein</fullName>
            <shortName evidence="14">PABP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSTA_018190</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and regulates mRNA decay through translation termination-coupled poly(A) shortening, probably mediated by PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EED16747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002483936.1"/>
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    <dbReference type="eggNOG" id="KOG0123">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_22_4_1"/>
    <dbReference type="InParanoid" id="B8MGJ6"/>
    <dbReference type="OMA" id="QQPGFMP"/>
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    <dbReference type="PhylomeDB" id="B8MGJ6"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
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    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RRM3_I_PABPs"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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        <property type="entry name" value="PABP_1234"/>
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        <property type="entry name" value="PABP_HYD_C"/>
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        <property type="entry name" value="RBD_domain_sf"/>
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        <property type="entry name" value="RRM2_I_PABPs"/>
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        <property type="entry name" value="RRM_euk-type"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MLLE"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="4"/>
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        <property type="match status" value="4"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
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    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 13 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="50"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
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            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
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            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="17">
        <location>
            <begin position="649"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
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            <end position="52"/>
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    <feature type="region of interest" description="Disordered" evidence="15">
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            <end position="751"/>
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    </feature>
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        <location>
            <begin position="1"/>
            <end position="42"/>
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    </feature>
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        <location>
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            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="610"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024761"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED16747.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="751" mass="80899" checksum="0453052043B19435" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8MH16</accession>
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            <fullName evidence="1">protein S-acyltransferase</fullName>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
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            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
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    <dbReference type="PANTHER" id="PTHR24161:SF85">
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    <feature type="repeat" description="ANK" evidence="4">
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED16830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1079" mass="117349" checksum="7A1D2C2D15E04971" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8MH38</accession>
    <name>B8MH38_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TMEM205-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_019140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484086.1">
        <property type="nucleotide sequence ID" value="XM_002484041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MH38"/>
    <dbReference type="GeneID" id="8104610"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_019140"/>
    <dbReference type="eggNOG" id="KOG2886">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094297_2_1_1"/>
    <dbReference type="InParanoid" id="B8MH38"/>
    <dbReference type="OMA" id="CYQALPM"/>
    <dbReference type="OrthoDB" id="1641132at2759"/>
    <dbReference type="PhylomeDB" id="B8MH38"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025423">
        <property type="entry name" value="TMEM205-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053009">
        <property type="entry name" value="Xanthocillin_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT PLANTS LEA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241:SF102">
        <property type="entry name" value="LD23009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13664">
        <property type="entry name" value="DUF4149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM205-like" evidence="6">
        <location>
            <begin position="14"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED16852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="183" mass="20302" checksum="49B7AD5EA56D5DC0" modified="2009-03-03" version="1">MLSTLLNPLPYHILAYGTFLGSQLYQSFINTNICFRSLPPQNFNNLNKRLFPVYFRCQLGFAVLTFVTRPPGTWLQLSAVNDVGNLLLGLATVMAGLNWYIFGPRTSDAMVEKARVLKEVQDEKDGDNVKAEGSHDSAETDAFVAKVKKTFSRNHAMSIHLNAIAMIATVGYGFVLGGRLQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHB3</accession>
    <name>B8MHB3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mediator complex subunit 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MED11</name>
        <name evidence="6" type="ORF">TSTA_021490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the Mediator complex subunit 11 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484326.1">
        <property type="nucleotide sequence ID" value="XM_002484281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHB3"/>
    <dbReference type="STRING" id="441959.B8MHB3"/>
    <dbReference type="GeneID" id="8107797"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_021490"/>
    <dbReference type="eggNOG" id="ENOG502S9BX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094325_1_0_1"/>
    <dbReference type="InParanoid" id="B8MHB3"/>
    <dbReference type="OMA" id="HSIDVRM"/>
    <dbReference type="OrthoDB" id="5418434at2759"/>
    <dbReference type="PhylomeDB" id="B8MHB3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019404">
        <property type="entry name" value="Mediator_Med11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22890">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10280">
        <property type="entry name" value="Med11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED17092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="177" mass="18812" checksum="E43419167989D6FD" modified="2009-03-03" version="1">MDESATSNSQTFSSADRIRQLNEIDKDIAKLVNSAGLAIQALTNAKSTEIMTGNSVNDRKAAFKASTSQYFALLSSIDVRLRRQVYALEEAGILESESATANNVSFKSDSGIGSTTTGGAGAGTAAGTFNPLEVSWLNSRKDTVGKDKEAESWAAAREFLNRGQDTAPKTETMDTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHC3</accession>
    <name>B8MHC3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_021590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484336.1">
        <property type="nucleotide sequence ID" value="XM_002484291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHC3"/>
    <dbReference type="STRING" id="441959.B8MHC3"/>
    <dbReference type="GeneID" id="8098425"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_021590"/>
    <dbReference type="eggNOG" id="ENOG502SU10">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1887165_0_0_1"/>
    <dbReference type="InParanoid" id="B8MHC3"/>
    <dbReference type="OrthoDB" id="1049195at2759"/>
    <dbReference type="PhylomeDB" id="B8MHC3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED17102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="135" mass="15089" checksum="FB64C8861EB5AF4D" modified="2009-03-03" version="1">MFFTYKGWQELKDFIRQTALHIRQAVVYDDQHGYPTGLGQIIVKNEDEAWRTYRESYLLSRQYYGANILIGKLSATGWDGQPLTVTLARASSPTRPIAGPAKSSSPSSYTVSYRENFARHSVAGTPTPESPVTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHE9</accession>
    <name>B8MHE9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit delta, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">F-ATPase delta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSTA_021850</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484362.1">
        <property type="nucleotide sequence ID" value="XM_002484317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHE9"/>
    <dbReference type="FunCoup" id="B8MHE9">
        <property type="interactions" value="729"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MHE9"/>
    <dbReference type="GeneID" id="8098451"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_021850"/>
    <dbReference type="eggNOG" id="KOG1758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084338_0_0_1"/>
    <dbReference type="InParanoid" id="B8MHE9"/>
    <dbReference type="OMA" id="PHQTIYR"/>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="PhylomeDB" id="B8MHE9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048938">
        <property type="entry name" value="ATPD_C_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21334">
        <property type="entry name" value="ATPD_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="14">
        <location>
            <begin position="36"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="F1F0-ATP synthase subunit delta C-terminal" evidence="15">
        <location>
            <begin position="122"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EED17128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="165" mass="17780" checksum="C4F869C4C10456F9" modified="2009-03-03" version="1">MSSLRFARAALRVRPTAIRVPAGHRTYADAVADKIKLSLAMPHQSLFKSTDVVQVNIPAESGEMGILANHVPSIEQLKPGLVEVIEESGGTKQFFLSGGFAVVQPDSRLSINAVEGYPLEDFSADAIRAQITEAQKIANGSGSEQDIAEAKIELEVLETLQMHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHN7</accession>
    <name>B8MHN7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translocation protein (Sec66), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_011270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483252.1">
        <property type="nucleotide sequence ID" value="XM_002483207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHN7"/>
    <dbReference type="FunCoup" id="B8MHN7">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MHN7"/>
    <dbReference type="GeneID" id="8109900"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_011270"/>
    <dbReference type="eggNOG" id="KOG4699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066294_0_0_1"/>
    <dbReference type="InParanoid" id="B8MHN7"/>
    <dbReference type="OMA" id="KPWFPAH"/>
    <dbReference type="OrthoDB" id="73168at2759"/>
    <dbReference type="PhylomeDB" id="B8MHN7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018624">
        <property type="entry name" value="Sec66"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229:SF1">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09802">
        <property type="entry name" value="Sec66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="266" mass="29559" checksum="ADA4D9D1F23B3D5F" modified="2009-03-03" version="1">MVDWISLAIPFAYLGILIGSLATFSSLYRKRKSARALSLAPWFPAHLQRDIYFSLLHLEQPAATNEKKTTAVPETVLKAALLRRAAEDIKRVIAIRDQKQALSLLLQRGSVGDDLWQRFLRAEKEMEEEVRDVVQEANAYVPNWGQVIFQSAREMDQNNLFRQRIEEYQSKVGEEVEWWTRRRAEIQEGFMKELDAEKAGTTTPAAAAAVTTAASATPAKAESTTVTAAPPSVTAVSDDDGVLVEAEVPKINSGTSSVKKKKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHZ9</accession>
    <name>B8MHZ9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="3">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_022170</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="3"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484395.1">
        <property type="nucleotide sequence ID" value="XM_002484350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHZ9"/>
    <dbReference type="STRING" id="441959.B8MHZ9"/>
    <dbReference type="GeneID" id="8098483"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_022170"/>
    <dbReference type="eggNOG" id="KOG1448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_4_0_1"/>
    <dbReference type="InParanoid" id="B8MHZ9"/>
    <dbReference type="OMA" id="LLPEHKC"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="PhylomeDB" id="B8MHZ9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000005">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF32">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="12">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED17161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="318" mass="33814" checksum="912589635D68D36E" modified="2009-03-03" version="1">MNEIKLISGTSHPDLSAKVADRLGISLTNTLCQPSSIGEISVSIGESVRGDDVYILQSTAPGTVNDGLMELLNLIHACRTASARSITAVIPNYPYARQDKKDKSRAPISARLVANMLQSAGTTHVITMDLHASQIQGFFNVPVDNLFAEPCVLDWVKRNVDASNCVIVSPDAGGAKRVASLADRLGVGFALIHKERPRPNVVGRMILVGDVSNRTAILIDDMADTCGTLAKAASTLEEHGAREVYAIVTHGVLSGSAIETINNSCLSGLVVTNTVPLGDKIARCPKIKVIDVSGVLAEAVRRTHNGESVSYLFNNVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MI09</accession>
    <name>B8MI09_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hyaluronan synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_022250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NodC/HAS family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484405.1">
        <property type="nucleotide sequence ID" value="XM_002484360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MI09"/>
    <dbReference type="STRING" id="441959.B8MI09"/>
    <dbReference type="GeneID" id="8098491"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_022250"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024200_0_0_1"/>
    <dbReference type="InParanoid" id="B8MI09"/>
    <dbReference type="OMA" id="KSATYVW"/>
    <dbReference type="OrthoDB" id="9876900at2759"/>
    <dbReference type="PhylomeDB" id="B8MI09"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050501">
        <property type="term" value="F:hyaluronan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085029">
        <property type="term" value="P:extracellular matrix assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030213">
        <property type="term" value="P:hyaluronan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22913">
        <property type="entry name" value="HYALURONAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22913:SF12">
        <property type="entry name" value="MANNURONAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="546"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="8">
        <location>
            <begin position="267"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED17171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="597" mass="68013" checksum="9C1409BC2EC2107F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIP3</accession>
    <name>B8MIP3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17 18">Plasma membrane ATPase</fullName>
            <ecNumber evidence="4 18">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TSTA_045910</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 18">Cell membrane</location>
            <topology evidence="2 18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="4 18"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485088.1">
        <property type="nucleotide sequence ID" value="XM_002485043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIP3"/>
    <dbReference type="FunCoup" id="B8MIP3">
        <property type="interactions" value="476"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MIP3"/>
    <dbReference type="GeneID" id="8107578"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_045910"/>
    <dbReference type="eggNOG" id="KOG0205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_6_0_1"/>
    <dbReference type="InParanoid" id="B8MIP3"/>
    <dbReference type="OMA" id="VIEFHPF"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="PhylomeDB" id="B8MIP3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02076">
        <property type="entry name" value="P-type_ATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000011">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000008">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 18" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 18" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="329"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="695"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="722"/>
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</entry>
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        </source>
    </evidence>
    <sequence length="414" mass="46575" checksum="2A061CE3C6DE8EA8" modified="2009-03-03" version="1">MEYHFVPQEERARDDKGNLLPWGYVYKDESRNPRRPPEESGPFGRRRNARYDHARSRTRTGTPAKKENPSVAEFSRLFSKQQEDERTNNTLPKSSSSSTLEGSRKVIEKVATECILYGYKNKETEWKVIDKYERISQGMICEDYPRNDPAVSNKYSQLLSGGDVVIRANLSADANRKSKRYAGGLHWIKVTFDSTIAADRACFFSPQEIDGHLVFCELYHGQGPAEDIPIPKESAEATCTRSKAHRTLTSSRSTAFLSDIEPECSTLPRSFGMGNLAAIKDIDEGNSQLSTPTASSATATAVAADPPSSLRQRTIQDTQLEQKPESEFMTHMPNVRRAVLRPISEALPPQPTVTERFLRSIPILSWFTGDIVGDGPQLGDDGKFDYSKSSFYWRFWFMMDQVLGTDICGLKEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8ML35</accession>
    <name>B8ML35_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_048910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485404.1">
        <property type="nucleotide sequence ID" value="XM_002485359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ML35"/>
    <dbReference type="GeneID" id="8100607"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_048910"/>
    <dbReference type="eggNOG" id="ENOG502SKBH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039661_0_0_1"/>
    <dbReference type="InParanoid" id="B8ML35"/>
    <dbReference type="OMA" id="RHLWTGK"/>
    <dbReference type="OrthoDB" id="3763672at2759"/>
    <dbReference type="PhylomeDB" id="B8ML35"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF3">
        <property type="entry name" value="NUCLEOTIDE-DIPHOSPHO-SUGAR TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED15451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="35244" checksum="4ECEC9029994A23C" modified="2009-03-03" version="1">MNAPFIHPITAPYFSTYEGYNFTLKNDPIWTKPLGKDLCVVDIDNRPFSKKHELFNEQPLNWDSFDKFSAGLLNHYLYAMIHGYRYAFVHLAQKPSDRYMSWAKVPAVIEHLKECKYLLNVEADAIFKELTLPMEWQMNYWNFTKNTKVAIPSDPNEDFNLDWEGKVNLNTGFILAQNTPRTFEIWEGWKSCVDDHVRFPGCEKFRDNWPAEQGAYSSIIRHAYNDPDDLLVIRCSEANEYPESGSDCIGSLNYQHFWIKKEQLLKDKAVVPMMQLMMQSLRLDLLIGKNEVLVKKQGFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B8ML49</accession>
    <name>B8ML49_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_049050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485418.1">
        <property type="nucleotide sequence ID" value="XM_002485373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ML49"/>
    <dbReference type="GeneID" id="8100621"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_049050"/>
    <dbReference type="HOGENOM" id="CLU_1670568_0_0_1"/>
    <dbReference type="InParanoid" id="B8ML49"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="158" mass="17568" checksum="B6D644F6689F189F" modified="2009-03-03" version="1">MNFERSPLDFQFLAPDFSSFWRFDKKEFGDVEDEEEGVGQHSADEEVVVEEPCLRTHEPSDELCNVDGAYRDMLYTTGVLQTKMWHAKRTALGIGAAQIREAFTTAQVPLVIDAYMVGLKAVFAITLAAFGIATLVGFMGHWKRLQMSELKKTAGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLL5</accession>
    <name>B8MLL5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Beta-1,6 glucan synthetase Kre6, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_049860</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485501.1">
        <property type="nucleotide sequence ID" value="XM_002485456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLL5"/>
    <dbReference type="FunCoup" id="B8MLL5">
        <property type="interactions" value="191"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MLL5"/>
    <dbReference type="GeneID" id="8108750"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_049860"/>
    <dbReference type="eggNOG" id="ENOG502QR13">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010811_4_1_1"/>
    <dbReference type="InParanoid" id="B8MLL5"/>
    <dbReference type="OMA" id="LPACTCK"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="PhylomeDB" id="B8MLL5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="13">
        <location>
            <begin position="261"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED15548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="673" mass="74700" checksum="C4784D8509687893" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLN8</accession>
    <name>B8MLN8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_101410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.24" evidence="3"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486139.1">
        <property type="nucleotide sequence ID" value="XM_002486094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLN8"/>
    <dbReference type="FunCoup" id="B8MLN8">
        <property type="interactions" value="261"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MLN8"/>
    <dbReference type="GeneID" id="8101829"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_101410"/>
    <dbReference type="eggNOG" id="KOG4342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003442_0_1_1"/>
    <dbReference type="InParanoid" id="B8MLN8"/>
    <dbReference type="OMA" id="DVFGFSW"/>
    <dbReference type="OrthoDB" id="10261055at2759"/>
    <dbReference type="PhylomeDB" id="B8MLN8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000004">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000002">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017:SF1">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="7">
        <location>
            <begin position="392"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED13901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="876" mass="99022" checksum="10BAA1571689B2C4" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLY3</accession>
    <name>B8MLY3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyltransferase family 28 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_097510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485733.1">
        <property type="nucleotide sequence ID" value="XM_002485688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLY3"/>
    <dbReference type="STRING" id="441959.B8MLY3"/>
    <dbReference type="GeneID" id="8108390"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_097510"/>
    <dbReference type="HOGENOM" id="CLU_1661969_0_0_1"/>
    <dbReference type="InParanoid" id="B8MLY3"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="PhylomeDB" id="B8MLY3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF27">
        <property type="entry name" value="GLUCOSYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED13495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="17910" checksum="9B00444C4712283F" modified="2009-03-03" version="1">MDHQKEAWIISGPSLLCPESVVEIEKNCKCKLNIVIQVVGSRGDVQPFIAFGNELQRWTPCVTSYAQCVRKLRQKVRVGILHSTHCVQASSIPVHLMFTMPWSSTESFPHSLASMSGGNADESLKNYVPYGVVDWLTWQVSLCFLLSSREFFDIVGLQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMN3</accession>
    <name>B8MMN3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_100320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486025.1">
        <property type="nucleotide sequence ID" value="XM_002485980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMN3"/>
    <dbReference type="STRING" id="441959.B8MMN3"/>
    <dbReference type="GeneID" id="8097916"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_100320"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_0_1"/>
    <dbReference type="InParanoid" id="B8MMN3"/>
    <dbReference type="OMA" id="KRWYERY"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="PhylomeDB" id="B8MMN3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF283">
        <property type="entry name" value="RETINOL DEHYDROGENASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED13787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="359" mass="39313" checksum="CC86EF5427649D98" modified="2009-03-03" version="1">MPATTHPEYNDSTEALEVAQAFAGNIRGRTVVITGVNRGGIGYATAEAFASQAPTHLIVIGRTMSKLEESIDAMKVKYPDVDYRALHIDLSSQQSVRSAAAKLLSWTDVPTIDFIINSAGIALLPERTFSVDGIEMVFATNHIGHFLFTCLLMPKLIKAAEKSPKGATRIVNVSSGSPTVARMRWSDMKYEKLNKDLPEQEQPFYDLQKAWGIDDPENKSYTPLEAYNVSKVANVLFGIGITKRLYEKHGILGLALHPGIIETELGRNAEPKIKDAVNSLREKGVYSYRPLGAGASTSMVAALDPKLGPGETKDGKENYGSFLSDCQISSNAQPLAVSSSEAEKLWKLSEEMVNQKFEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMT7</accession>
    <name>B8MMT7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome c oxidase subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cytochrome c oxidase polypeptide VIa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_100840</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome c oxidase subunit 6A family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486081.1">
        <property type="nucleotide sequence ID" value="XM_002486036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMT7"/>
    <dbReference type="FunCoup" id="B8MMT7">
        <property type="interactions" value="249"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MMT7"/>
    <dbReference type="GeneID" id="8097968"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_100840"/>
    <dbReference type="eggNOG" id="KOG3469">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122515_0_0_1"/>
    <dbReference type="InParanoid" id="B8MMT7"/>
    <dbReference type="OrthoDB" id="5947505at2759"/>
    <dbReference type="PhylomeDB" id="B8MMT7"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.95.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6A, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.95.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001349">
        <property type="entry name" value="Cyt_c_oxidase_su6a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018507">
        <property type="entry name" value="Cyt_c_oxidase_su6a_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036418">
        <property type="entry name" value="Cyt_c_oxidase_su6a_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02046">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81411">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01329">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED13843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="191" mass="22315" checksum="5FE961981568D715" modified="2009-03-03" version="1">MSWRGRMKLGSGTPANHGAKLTDFVRPPEPSSHFNLEQEQQTRPIALYRTMLPQHNMQRLGLRMVKQTRSTPARNVVQRRFNSTQVNKPDWIVDNAFNREREAVKHHAASTSKLWLRLSIFGVIPCLIGGSINAYNLWNEHWEHWNHLPPLEERTEYSYQNIRTKNFPWGDGDKTIFWNSAVNYHNPDKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8MND5</accession>
    <name>B8MND5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_102550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486262.1">
        <property type="nucleotide sequence ID" value="XM_002486217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MND5"/>
    <dbReference type="STRING" id="441959.B8MND5"/>
    <dbReference type="GeneID" id="8100831"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_102550"/>
    <dbReference type="eggNOG" id="ENOG502SMKX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033726_0_1_1"/>
    <dbReference type="InParanoid" id="B8MND5"/>
    <dbReference type="OMA" id="PDHCLLT"/>
    <dbReference type="OrthoDB" id="2245989at2759"/>
    <dbReference type="PhylomeDB" id="B8MND5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF1">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED14024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="271" mass="31247" checksum="1586EEF5FA7D5292" modified="2009-03-03" version="1">MPMATVELAPMPQLAEARCKDDDWTGLSDKAERRRRQTRLALRALRKRKAAQRAVRLESGTEKFITHYREPGQNSQLHLASTLIIPSYVSVNGRIVPERYLYPLSRDHLLPLLEYNIYRATITNLLIIGHMHLIHENCGFHGPLTIFPNPYQGISIPPALRRTILQQTVSYPDWVDLIPSPQMRDNAIRTQHLFTNKDLASDILTGMMGQEDRKDPGMLVWSDPWDPSGWELTEGFVKKWGFLVQGCYDLFRSTNYWRNVRGERPLSLAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8MP21</accession>
    <name>B8MP21_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_104740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486498.1">
        <property type="nucleotide sequence ID" value="XM_002486453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MP21"/>
    <dbReference type="STRING" id="441959.B8MP21"/>
    <dbReference type="GeneID" id="8098695"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_104740"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1001760_0_0_1"/>
    <dbReference type="InParanoid" id="B8MP21"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="PhylomeDB" id="B8MP21"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="278" mass="30971" checksum="AA06AB4DEC453C24" modified="2009-03-03" version="1">MIALDLASIEKTPVLYRHLELALKSNNKFVKDVNSSGSMEICSLRLVENRTMQYSIGACGLLSKEVDHSSMGLRDGEGRSEKGWYNKEVLQTYDSERRAAPRHLLQTDKVLPTVICGQIPKEYKTASTHCRKLFSESRAPDVLVYQPGSHIPNRLSQLRYDMDSWPILLFTGQHKVTEAKLPAITNKLDNMAKNFPSYMIGSITIVAGSMEDNQRCNLATVGYTYYDPGGWAHLTYRISPKTGALVVLRPDFLIGYATTPDDAGSVRAFLANPILAPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPL3</accession>
    <name>B8MPL3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NACHT and WD40 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_106620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486690.1">
        <property type="nucleotide sequence ID" value="XM_002486645.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MPL3"/>
    <dbReference type="GeneID" id="8103562"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_106620"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_6_16_1"/>
    <dbReference type="InParanoid" id="B8MPL3"/>
    <dbReference type="OMA" id="ERTRTHE"/>
    <dbReference type="OrthoDB" id="4226663at2759"/>
    <dbReference type="PhylomeDB" id="B8MPL3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <sequence length="1813" mass="202332" checksum="096B036659F7FE6C" modified="2009-03-03" version="1"> </sequence>
</entry>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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                <person name="Fedorova-Abrams N.D."/>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="248" mass="29001" checksum="8CFEAF7A413FA08F" modified="2009-03-03" version="1">MISKALRLRKEVTQFIREHPDIREIQIQKVLKPFWDHTNSVSKHCLSITESLPIYWSLNDILDNIKNNKGDFQEITKEIQNAVEGGIRKMDKFTKKMDSNIIYYVAAILNPQVKTSFIQAQISKSDADMIVSDIREYLKKQYPASPTSSSSAERPPDSSPEMWFHNMIEDRDPNWILKWWKANAFNYPLMLKAVQDYLPIPSAEVGVERLFSNARDVLGIRRHCLNSEMFRWLMFLKGQYGKERRDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPV3</accession>
    <name>B8MPV3_TALSN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">TSTA_052820</name>
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        <lineage>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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    <dbReference type="STRING" id="441959.B8MPV3"/>
    <dbReference type="GeneID" id="8098231"/>
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    <dbReference type="HOGENOM" id="CLU_2063046_0_0_1"/>
    <dbReference type="InParanoid" id="B8MPV3"/>
    <dbReference type="OrthoDB" id="3598698at2759"/>
    <dbReference type="PhylomeDB" id="B8MPV3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED12761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="119" mass="13506" checksum="0AF39D7C881F2479" modified="2009-03-03" version="1">MLKGQALDFYYDNKEIWEASDCDPVEGIRAYFEGPEYHRTILDKWSGISLQNIVDENPEKTLKVTRTHPACQLATSKQQDTVPGLTRDLQSGVSQYEDMIKATNGRRTANPSTNAYFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B8MR98</accession>
    <name>B8MR98_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="17">RSC complex subunit (Sth1), putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="17" type="ORF">TSTA_055020</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
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    </dbReference>
    <dbReference type="STRING" id="441959.B8MR98"/>
    <dbReference type="GeneID" id="8100508"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_055020"/>
    <dbReference type="eggNOG" id="KOG0386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_15_3_1"/>
    <dbReference type="InParanoid" id="B8MR98"/>
    <dbReference type="OMA" id="VNYISHT"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="PhylomeDB" id="B8MR98"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
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    <sequence length="1420" mass="162071" checksum="228A32D71393CA85" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRJ0</accession>
    <name>B8MRJ0_TALSN</name>
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        <recommendedName>
            <fullName evidence="8">Probable transporter MCH1</fullName>
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        <name evidence="11" type="ORF">TSTA_056260</name>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
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    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
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        <text evidence="2">Belongs to the major facilitator superfamily.</text>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
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        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED13127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="633" mass="69562" checksum="5DA30FDDD74C1508" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRZ0</accession>
    <name>B8MRZ0_TALSN</name>
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        <submittedName>
            <fullName evidence="6">Monocarboxylate permease, putative</fullName>
        </submittedName>
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        <name evidence="6" type="ORF">TSTA_059140</name>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <dbReference type="NCBI Taxonomy" id="441959"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
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    <dbReference type="OMA" id="LYWHFVL"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="PhylomeDB" id="B8MRZ0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
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            <end position="115"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="506" mass="55500" checksum="AA3CD9BF95F24911" modified="2009-03-03" version="1">MALESSSSSIHPTQDNGRLFSTPRSDDYNTLSIEISNFLPFGNIATATDRTTKHLIPPQEDAHGDAFPPSDHPPVSPETVVVDSFPDGGTRSWLVVLGSFFLLMASYGMLNSVGVFQSYLEANQLSSYSSTDVGWIPSIFVFVTLLLGVYIGPLFDSHGPKMLVYVGSAIFMLSLFLFAECKRYWQFLLTFGILGGIGAALVSTVGMACVPHWFEMRAGMAIGTALAGGGLGGAVFPFVLRAGFSNIGFKWTMRTLAFVVGFLCLLGSFMVRARLPRRKTSKVVIDLRCFKDLKFSWMTFSTFCTSHSSNSLDKPVGQATDKRLTGLELQYFSLLGMYPTFITTLGFSTNTSIYLIVIMNICGMIGRLVAGRIADGYGRLNTLNIVVVLTVIWLFALLYPFQTSLPILYIFSCMYGLTSGSFISLAPVCIRQISDAKEIGLRFGTCYSVVSFALLVSIPVTGELMQKGGPKAMIIWSGALLLWTTGLLALTRWTCLSYNWKWKVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8MS32</accession>
    <name>B8MS32_TALSN</name>
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        <recommendedName>
            <fullName evidence="2">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_002740</name>
    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002487819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MS32"/>
    <dbReference type="STRING" id="441959.B8MS32"/>
    <dbReference type="GeneID" id="8102885"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_002740"/>
    <dbReference type="eggNOG" id="ENOG502RXW6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033263_0_0_1"/>
    <dbReference type="InParanoid" id="B8MS32"/>
    <dbReference type="OMA" id="MTGNWGQ"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="PhylomeDB" id="B8MS32"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36459:SF1">
        <property type="entry name" value="FATTY ACID DESATURASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36459">
        <property type="entry name" value="ORF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
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            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="2">
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            <begin position="157"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED12210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="443" mass="51957" checksum="6F97596159B294D0" modified="2009-03-03" version="1">MDLQAFIDPNLPEADLLVLKHLHHDIDSYEDTNNASSSSRQQIPDNSITKRNVPAAVENVDALITQLDALNDPSQSSFEPTVFVTFDMGYLRTKLHPYIYKNFLVPYISIARKIVRVDTDVVMLTHLLLYFSTSVPSAIFLYRHFTYLHGVLHWLMQSYYVGTYTLMMHQHIHMGGILTKSNPFIHAFDVLFPYITNPLMGHTWNSYYYHHIKHHHVEGNGPGDLSSTIRYQRDSIPDFLHYVLRFMFFVWIELPLYFFRHGKFLLGLKAFFWEFSTYITIAVLYSYVDARATIFAFILPLFMLRIGLMVGNWGQHALVDEEEPTSDLRSSITLIDVASNRFCFNDGYHTSHHLNPRRHWRDHPAAFLRAKEKYATERALVFKNIDYIMMTVKLMQKDYIYLAKCLVPIGEKQIRMSLQERAEMLRSKTRRFSEDEIRVKYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTZ0</accession>
    <name>B8MTZ0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc knuckle nucleic acid binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_006450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488277.1">
        <property type="nucleotide sequence ID" value="XM_002488232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTZ0"/>
    <dbReference type="STRING" id="441959.B8MTZ0"/>
    <dbReference type="GeneID" id="8105330"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_006450"/>
    <dbReference type="eggNOG" id="KOG4400">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058879_0_2_1"/>
    <dbReference type="InParanoid" id="B8MTZ0"/>
    <dbReference type="OMA" id="GTIGHYA"/>
    <dbReference type="OrthoDB" id="3863715at2759"/>
    <dbReference type="PhylomeDB" id="B8MTZ0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000012">
        <property type="entry name" value="Cellular nucleic acid-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000016">
        <property type="entry name" value="Cellular nucleic acid-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000085">
        <property type="entry name" value="Zinc knuckle nucleic acid binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051714">
        <property type="entry name" value="Znf_CCHC_NABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23002">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="199"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED12623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="265" mass="26727" checksum="3D845E782E36ECED" modified="2009-03-03" version="1">MLLSRRACYKCGNIGHYAEVCSSAERLCYNCTYRCHESNACPRPRTTETKQCYHCQGLGHVQADCPTLRLNGGANGGRCYGCGQPGHLARNCPTPNIQTGAGRGSGAPRGNFGGSLRGGFGGYPRAATCYKCGGPNHFARDCQAQAMKCYACGKLGHISRDCTAPNGGPLSSAGKVCYKCSQAGHISRDCPTNENKPQPSADKATPVAAAATTTTPAAPGATSTAVATSPVAAPAAPAAPAAAIDGSADVVAAAPSAAATTTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B8MU75</accession>
    <name>B8MU75_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_111080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488687.1">
        <property type="nucleotide sequence ID" value="XM_002488642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MU75"/>
    <dbReference type="STRING" id="441959.B8MU75"/>
    <dbReference type="GeneID" id="8110137"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_111080"/>
    <dbReference type="eggNOG" id="ENOG502S7QN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_872033_0_0_1"/>
    <dbReference type="InParanoid" id="B8MU75"/>
    <dbReference type="OrthoDB" id="7171700at2759"/>
    <dbReference type="PhylomeDB" id="B8MU75"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="319" mass="34844" checksum="3F2AE26A03F804AA" modified="2009-03-03" version="1">MIKPPTVNVPNRQLLTFLNHQLSIGNWINRELAQPPTVNLPNYQLFNDQRPSWLNRHLAPCSIVNCLLRSANCQLTLPVTGNLLIHQLSTNLAGDWQLAQPSTDNSQLQLAQPPTVNWLPRSTTNWSTGSSSTTFLAEPSSSQLSTVKRLNRHLSTGSITNCQMFEPPSRTLLNRQLSTCSIVNCQLSNGSTVNCQTAQLPSGNLVNRQLSTGSADNCQMLDPRSATLLNHQLSTVNCQLSTCPTTNCPLAQSSTVNRQLAQPPTVNLSASDWQLAQLSTDNSQLATCSTTANYQFVQSLIDNCELPACLIVHCQPSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUC9</accession>
    <name>B8MUC9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_108210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488389.1">
        <property type="nucleotide sequence ID" value="XM_002488344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUC9"/>
    <dbReference type="STRING" id="441959.B8MUC9"/>
    <dbReference type="GeneID" id="8106885"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_108210"/>
    <dbReference type="eggNOG" id="KOG1121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009123_10_3_1"/>
    <dbReference type="InParanoid" id="B8MUC9"/>
    <dbReference type="OMA" id="THIRCSA"/>
    <dbReference type="OrthoDB" id="4505704at2759"/>
    <dbReference type="PhylomeDB" id="B8MUC9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED11633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="39761" checksum="DDC6D21EBDBD9403" modified="2009-03-03" version="1">MGHGKKLQSASSSIHLSLDIWTSPNRILFLGICAHFVEQSQERLCKGLLALRTVGNHSGDEQFATLLPVLKDYGIQQKLCRVLGKYLQEEGIKWDPTYRRIFCIGHVINLAVQAFLFQNILEIEQLSSWDEIEVTEATEDEELQRQVTIYKIGPLGKLHNIVTHIRCSAGRTKEFKDLAGRLIPLDNRTRWNSWYHILYVVLQFDGAIDTYTKRHFAILEIEYLSPLDWERLHRTSKFLSLFNHATLKTQEDQATIDNVLFVMDIIIKHFEKALEEYRQKAPTYMVVQSYERNTQDLDDFDQIAHDLGKFARPASQDEYEDYNSESPYEIRTSALTWWCQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUW8</accession>
    <name>B8MUW8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_109150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488492.1">
        <property type="nucleotide sequence ID" value="XM_002488447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUW8"/>
    <dbReference type="GeneID" id="8107147"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109150"/>
    <dbReference type="HOGENOM" id="CLU_1971963_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUW8"/>
    <dbReference type="PhylomeDB" id="B8MUW8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="127" mass="14409" checksum="702DBA1D0B1012F2" modified="2009-03-03" version="1">MTFLRNYGIFEFKPLLRELFTTVGKIEEFGHIILISSPTTKSISPPSTVTALRRYINKIEESIEGINDILEKSKPDLVRRIKVVNSSSLAMAGLGELHREDFVRLHDTAKRKNNKKNKRQVKASGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUX0</accession>
    <name>B8MUX0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_109170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488494.1">
        <property type="nucleotide sequence ID" value="XM_002488449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUX0"/>
    <dbReference type="GeneID" id="8107149"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109170"/>
    <dbReference type="HOGENOM" id="CLU_000680_26_1_1"/>
    <dbReference type="InParanoid" id="B8MUX0"/>
    <dbReference type="OrthoDB" id="4357294at2759"/>
    <dbReference type="PhylomeDB" id="B8MUX0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="230" mass="24634" checksum="1AF7DF1ACE37E67D" modified="2009-03-03" version="1">MGCTKEQAAADFLDFRHTIPGSDITVFSGGPKLENGHAGEVFDTEEEAALAGAQAALSTARFATNMWICLGNLEAATRLLTPSTGSSQEAFESFCALAATWPLRERLPHTKSGSIQVRWVPGHAKIPENETADLAAKEGVASTSPPPHTISYASLERNAKAQSFAAAQTLWQNVLLQTYQDLGITTSPNLLSAQLSFNSPDLTSAISPRPVLDVETSRTTMKDSTMKIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8MV02</accession>
    <name>B8MV02_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_110710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488648.1">
        <property type="nucleotide sequence ID" value="XM_002488603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MV02"/>
    <dbReference type="GeneID" id="8101443"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_110710"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051551_2_1_1"/>
    <dbReference type="InParanoid" id="B8MV02"/>
    <dbReference type="OrthoDB" id="4526357at2759"/>
    <dbReference type="PhylomeDB" id="B8MV02"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="134" mass="14160" checksum="33882DFB123F0872" modified="2009-03-03" version="1">MARKGPGTDGPLQTALLESTSAATTRASEGQKIFSPIAAFLDKHRSQTTGLAPHLLRALTALSDDLAAVAQQHFNAYISALKEVQATKTGFALCPSSPEALLALKAQKETISAFFVNCQIERSSDGSHTESPMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MV08</accession>
    <name>B8MV08_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nonsense-mediated mRNA decay protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_110770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488654.1">
        <property type="nucleotide sequence ID" value="XM_002488609.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MV08"/>
    <dbReference type="GeneID" id="8101449"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_110770"/>
    <dbReference type="eggNOG" id="KOG1807">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001490_1_1_1"/>
    <dbReference type="InParanoid" id="B8MV08"/>
    <dbReference type="OMA" id="QCGHFLT"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="PhylomeDB" id="B8MV08"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17936">
        <property type="entry name" value="EEXXEc_NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001660">
        <property type="entry name" value="NF-X1 finger and helicase protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046439">
        <property type="entry name" value="ZF_RZ_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF445">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20173">
        <property type="entry name" value="ZnF_RZ-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51981">
        <property type="entry name" value="ZF_RZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RZ-type" evidence="8">
        <location>
            <begin position="1763"/>
            <end position="1835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED11898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1842" mass="208239" checksum="02091CFD17F89FC1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MVD2</accession>
    <name>B8MVD2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_007820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962663">
        <property type="protein sequence ID" value="EED11492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488808.1">
        <property type="nucleotide sequence ID" value="XM_002488763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MVD2"/>
    <dbReference type="STRING" id="441959.B8MVD2"/>
    <dbReference type="GeneID" id="8103456"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_007820"/>
    <dbReference type="eggNOG" id="ENOG502S0H3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_26_1_1"/>
    <dbReference type="InParanoid" id="B8MVD2"/>
    <dbReference type="OMA" id="DICWRNV"/>
    <dbReference type="OrthoDB" id="5080849at2759"/>
    <dbReference type="PhylomeDB" id="B8MVD2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="55"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED11492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="290" mass="31774" checksum="BD6F094869636C03" modified="2009-03-03" version="1">MADKPADLPAINPLQYAPWHPREPRGNAQARIGAPMGRTKEQAAANFMAFQRTIPSSDIVIFSDGSRLADGRAGGGYIRLQAHHQFLRSSLSYRHGKEVFDAEAEAALAGAQAAIAYPTAQFATNLWICLDNLEVAIRLLSPSTGSSQEIFESFRTLAAAWPLRKRLPHTKSGSIQIRWVPGHAKIPENEAADLTAKEGAASTPPAPQKSSYASLKRHAKTQSLSAAQSQWQKVAPQSYQDLEITTSPKRPGELQLNRLDLGRIIAARTGHGDFADYHERFNHDDAYLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>H9CNM7</accession>
    <name>H9CNM7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Intron-encoded LAGLIDADG endonuclease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_m0440</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="3"/>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="BMC Genomics" volume="13" first="698" last="698">
            <title>Sequencing of mitochondrial genomes of nine Aspergillus and Penicillium species identifies mobile introns and accessory genes as main sources of genome size variability.</title>
            <authorList>
                <person name="Joardar V."/>
                <person name="Abrams N.F."/>
                <person name="Hostetler J."/>
                <person name="Paukstelis P.J."/>
                <person name="Pakala S."/>
                <person name="Pakala S.B."/>
                <person name="Zafar N."/>
                <person name="Abolude O.O."/>
                <person name="Payne G."/>
                <person name="Andrianopoulos A."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="23234273"/>
            <dbReference type="DOI" id="10.1186/1471-2164-13-698"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JQ354994">
        <property type="protein sequence ID" value="AFD95921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9CNM7"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_m0440"/>
    <dbReference type="InParanoid" id="H9CNM7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051289">
        <property type="entry name" value="LAGLIDADG_Endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36181">
        <property type="entry name" value="INTRON-ENCODED ENDONUCLEASE AI3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36181:SF4">
        <property type="entry name" value="LAGLIDADG ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00961">
        <property type="entry name" value="LAGLIDADG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003618777" evidence="1">
        <location>
            <begin position="29"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Homing endonuclease LAGLIDADG" evidence="2">
        <location>
            <begin position="210"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFD95921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="348" mass="40029" checksum="48DF5AB7E0AC6730" modified="2012-05-16" version="1">MASPYSNISVYFFAICLDSFMLISTLNGKNLISTTQWANNLSLYFLENKIQSVSETTCETSFNFSLFRIYYYKLFNSNSEHLSDNWLIWFIGFVEGDGAIQTYDNGNRVRFVLTQKESAILYFIHNKLNIGIVKHFPQGKSGKNNDFYRLIVDNPSQILLLAFLFNGNLAMDHRIKQLSLWIQSLNMRFGDNTITFLNNPVFISLQDAWLSGFTDAEGCFNVSITSNSRYKLGHVIKMRFLLNQKDSIILAKIRDLFNTGKVNIRSGTTGVFRYTVTGYKSINTIKNYFEMFPLYTKKADSLKKWCIIHDMVINKIHLTKEGLAKIRMLQKQINVNNSITNKTGVSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTJ4</accession>
    <name>B8LTJ4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial dicarboxylate carrier protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_065280</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340459.1">
        <property type="nucleotide sequence ID" value="XM_002340418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTJ4"/>
    <dbReference type="FunCoup" id="B8LTJ4">
        <property type="interactions" value="915"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LTJ4"/>
    <dbReference type="GeneID" id="8104699"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_065280"/>
    <dbReference type="eggNOG" id="KOG0759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_14_1_1"/>
    <dbReference type="InParanoid" id="B8LTJ4"/>
    <dbReference type="OMA" id="TLWRGAI"/>
    <dbReference type="OrthoDB" id="756301at2759"/>
    <dbReference type="PhylomeDB" id="B8LTJ4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000009">
        <property type="entry name" value="Mitochondrial 2-oxoglutarate/malate carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="41"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="142"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="231"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED23072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="324" mass="34631" checksum="B18E58E0971C30B5" modified="2009-03-03" version="1">MASRSITESASSATKSARESTKAAIENPSATATSFLRHPYMQAALPFINGGLAGMTATVVIQPVDMIKVRLQLAGEGQKTGPKPTALGITKNIIASGKVLDLYTGLSAGLLRQAVYTTARLGFFDTFITIAKTRAAEQGRSVSFGERALAGLTAGGLAAMIGNPADLALIQSRANYRSVIDALSRISKTEGIGALWAGATPTVVRAMALNLGQLAFFSESKSQLKAHTNLSPQVQTFAASAIAGFFASFLSLPFDFVKTRLQKQQKNPVTGELPYKGVLDCTRKVIKDEGWLRFYRGFGTYYIRIAPHAMVTLIVADYLNLITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>B8LU71</accession>
    <name>B8LU71_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_060380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002339930.1">
        <property type="nucleotide sequence ID" value="XM_002339889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LU71"/>
    <dbReference type="GeneID" id="8102645"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_060380"/>
    <dbReference type="HOGENOM" id="CLU_1714524_0_0_1"/>
    <dbReference type="InParanoid" id="B8LU71"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED22543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="153" mass="17467" checksum="CD774EC9E598B7D5" modified="2009-03-03" version="1">MENKLGPHHIHNESDDEIIYEPDCLCTTKHLWDSGDFCPGSIARLLFLGITLLDFTQGRLNEPTSTRFDFVNLTITKGIIKDAFQTIYSKIEARPANVDQWTRIHSRLQLEYTRAMSIGGPYTPARVESVKPIIEILIQNIKEIAEEIQQLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8LV18</accession>
    <name>B8LV18_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_061300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340026.1">
        <property type="nucleotide sequence ID" value="XM_002339985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LV18"/>
    <dbReference type="GeneID" id="8103891"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_061300"/>
    <dbReference type="HOGENOM" id="CLU_013929_14_2_1"/>
    <dbReference type="InParanoid" id="B8LV18"/>
    <dbReference type="OrthoDB" id="4230168at2759"/>
    <dbReference type="PhylomeDB" id="B8LV18"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="34"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="363"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED22639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="404" mass="45594" checksum="99E6758A6D6BC2F1" modified="2009-03-03" version="1">MTPKLYKEEEALIAKALARANTKEKPPNFSKLAHYMGTPPTNQQIEESANYLLAKDFTGPGEPPRAGKTWVYNFVGRLPEKYVRIVQKPQEKEPFPKTSKRVSSLSSRESITIVEGVSAKGKIIPPLLIPKGKVHLEEWYRHLQDDEWLQYKHVHGRVVNKVARLGGFDFDKNDFFEELRDIRIKTFTTRTIRNGWRERGIWPLNPQLILDKMSSPEEAFEAMVAEGDTLKIYGEAYDTIPSSPTTKSISPPSTVIKLRRYINKIEKSIDSIKDILDGASPGLSKRIKTVNQGSLTLAELGNLHRESFAKVRETAERKNQKSTRRHVKASGALYVKDANRLIKRRHDGDLLRIHKSHVLGVLQPEEEEAPTEPQNYGFFFDTQGPPADSQPQGGGGDATGSDPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVH5</accession>
    <name>B8LVH5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_073800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341381.1">
        <property type="nucleotide sequence ID" value="XM_002341340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVH5"/>
    <dbReference type="STRING" id="441959.B8LVH5"/>
    <dbReference type="GeneID" id="8103936"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_073800"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="InParanoid" id="B8LVH5"/>
    <dbReference type="OMA" id="YFFDPAM"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="PhylomeDB" id="B8LVH5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF18">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="54"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED23994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="551" mass="60299" checksum="4BB3A0C3D9E348BD" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVS1</accession>
    <name>B8LVS1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutaredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_075730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341588.1">
        <property type="nucleotide sequence ID" value="XM_002341547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVS1"/>
    <dbReference type="GeneID" id="8100172"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_075730"/>
    <dbReference type="eggNOG" id="ENOG502SC8X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1273016_0_0_1"/>
    <dbReference type="InParanoid" id="B8LVS1"/>
    <dbReference type="OrthoDB" id="429967at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008554">
        <property type="entry name" value="Glutaredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052565">
        <property type="entry name" value="Glutaredoxin-like_YDR286C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33558">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33558:SF1">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05768">
        <property type="entry name" value="Glrx-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED24201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24961" checksum="D1AEC1CEE5D8E2D2" modified="2009-03-03" version="1">MRFTRTLLNSQPARLTLFTRAQCGLCDTAKLTLSQLQQRRTFRYNEVDIMAPKNKKWKDVYEFDVPVLHVQPANSDEESKLRKLFHRFSEVEIVKVVDEVVSVAKYHGHEFAESIKCFGNEKTATSAKESPTMIAICTRRPVACTARRSRRFINGKPSWPVAYWEVEAAYQKCKREMLNSKTGYMLASEHALSDNLAVAVDEFYIITNRAISSRVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWM1</accession>
    <name>B8LWM1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_077770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341805.1">
        <property type="nucleotide sequence ID" value="XM_002341764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWM1"/>
    <dbReference type="GeneID" id="8110230"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_077770"/>
    <dbReference type="eggNOG" id="ENOG502SU37">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141137_1_0_1"/>
    <dbReference type="InParanoid" id="B8LWM1"/>
    <dbReference type="OMA" id="SLGRVWN"/>
    <dbReference type="OrthoDB" id="5201563at2759"/>
    <dbReference type="PhylomeDB" id="B8LWM1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED24418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="133" mass="15375" checksum="963C983C5ADE3009" modified="2009-03-03" version="1">MSRTSTLLSSTETLARLRVVGYLSDYDIHHSSTSHIPNSEIIDELPSPPLQSPDLNRESPEWPNHYRRIPPYRPVNHDLDQGQRRVYTSGPERAFIAIMFLGVRNNARLNKLWRMTGEKINDQVFGYKIGGEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWN0</accession>
    <name>B8LWN0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_077880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341814.1">
        <property type="nucleotide sequence ID" value="XM_002341773.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LWN0"/>
    <dbReference type="GeneID" id="8102387"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_077880"/>
    <dbReference type="eggNOG" id="KOG2029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003781_1_0_1"/>
    <dbReference type="InParanoid" id="B8LWN0"/>
    <dbReference type="OrthoDB" id="427518at2759"/>
    <dbReference type="PhylomeDB" id="B8LWN0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056251">
        <property type="entry name" value="Arm_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055496">
        <property type="entry name" value="DUF7068"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23948">
        <property type="entry name" value="ARM_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23238">
        <property type="entry name" value="DUF7068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1657"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="445"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED24427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1676" mass="190999" checksum="3FA055C306BEEC74" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXU7</accession>
    <name>B8LXU7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_062490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340149.1">
        <property type="nucleotide sequence ID" value="XM_002340108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXU7"/>
    <dbReference type="STRING" id="441959.B8LXU7"/>
    <dbReference type="GeneID" id="8104192"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_062490"/>
    <dbReference type="eggNOG" id="ENOG502SIP1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1284034_0_0_1"/>
    <dbReference type="InParanoid" id="B8LXU7"/>
    <dbReference type="OMA" id="CFANETH"/>
    <dbReference type="OrthoDB" id="4232626at2759"/>
    <dbReference type="PhylomeDB" id="B8LXU7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED22762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="215" mass="24047" checksum="3224596CB75C3D5C" modified="2009-03-03" version="1">MCTIAVAREVDRGIFCLEESGFISSNNELASQAETWEQTSLYAPTPGNLDRHTPSVYCPSTSRLNAERSSSLPLPAGLGYHDEAGNGNLRSRQDDAQTYINYPIEYRALVNNRSVARATEKDVVLKPSSYWQQIKEKADQAVRQRWRKASNRHVRSDETTIVVSVNDRSKRDLTCNISFFLGGKSPSDSQNWTPNFEEVRASIPFAIATGRLDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8LY80</accession>
    <name>B8LY80_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Telomere silencing protein Zds1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_067600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340712.1">
        <property type="nucleotide sequence ID" value="XM_002340671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LY80"/>
    <dbReference type="STRING" id="441959.B8LY80"/>
    <dbReference type="GeneID" id="8107327"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_067600"/>
    <dbReference type="eggNOG" id="ENOG502S3J1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004908_0_0_1"/>
    <dbReference type="InParanoid" id="B8LY80"/>
    <dbReference type="OMA" id="VDYNWTR"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="PhylomeDB" id="B8LY80"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040206">
        <property type="entry name" value="Zds1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013941">
        <property type="entry name" value="ZDS1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089:SF1">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08632">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01327">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein Zds1 C-terminal" evidence="2">
        <location>
            <begin position="690"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="748"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="809"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="756"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED23325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="842" mass="94373" checksum="55627E2B90F10095" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYT3</accession>
    <name>B8LYT3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_068640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340828.1">
        <property type="nucleotide sequence ID" value="XM_002340787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYT3"/>
    <dbReference type="STRING" id="441959.B8LYT3"/>
    <dbReference type="GeneID" id="8110208"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_068640"/>
    <dbReference type="eggNOG" id="ENOG502S3ED">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013866_1_1_1"/>
    <dbReference type="InParanoid" id="B8LYT3"/>
    <dbReference type="OrthoDB" id="3525185at2759"/>
    <dbReference type="PhylomeDB" id="B8LYT3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="43642" checksum="5B00F2C52F839153" modified="2009-03-03" version="1">MVNYGVSRACETCRNGERRSGRVCLGYRSNDELRFHHHIVTMNVPVQSFPISEGSIAEDAVGFFLNQYVVYSTDPRVSRGFLDGLPSLLSNAHRSSNLVQAVEIVAWTSIGIQLARPESLVRARREYVLLQSCQTHAPTVEALVIAILLDLYEIVSGGEISSEQQSMLPMSGESNPLGTLQELQTTLDCALAIELAFSLWNVNLDPSWKAHIVGHITQTDAEASSCPFARSDPVHTYFDIYVAAVMNTYRKTYLMLLDISIHLASRIEESIQTNIVMGWEQQVHILINDIIASVLYHLTNNLHDYLQAIISSSKSPGIGRSVEGLLLLHHLYVLSTCSIVSSLIRSYARKCPAWSWRHMRIGQGTLMSKQREKKKPLPSENRTAHAPNKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZK4</accession>
    <name>B8LZK4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Salicylate hydroxylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_096760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479390.1">
        <property type="nucleotide sequence ID" value="XM_002479345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZK4"/>
    <dbReference type="STRING" id="441959.B8LZK4"/>
    <dbReference type="GeneID" id="8103519"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_096760"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_2_1"/>
    <dbReference type="InParanoid" id="B8LZK4"/>
    <dbReference type="OMA" id="QSCLHAN"/>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="PhylomeDB" id="B8LZK4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000201">
        <property type="entry name" value="Salicylate hydroxylase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF172">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="15"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED22427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="425" mass="47332" checksum="C4E47FDD2F77E5BF" modified="2009-03-03" version="1">MISKTESATWQPLSIAVVGGGIGGLAAGISLRRAGHAVTIYERADYAGEVGASISCAANGTRWLHEWGVNVEMGDPVILRKLINRDWETGEATNVYDLADYEEKWGHVYNMFHRQYMHAMLMDSALGEAGEGTPVKLVVNHKCVNIDSESGLITFENGNTAQHDVVIGADGIGSVVRGLIDIHQEKKPSSSSCLHTNVTTEEAVALGLIDYSKNSAIEYWGGHGTPNKIVLSPCNGGKLLSYYCFFPREKGDYATQKWDEEATVEELLAPYPDLDRNVFKHLSIGKDIRPWRLWVHQPYEWWQKGVVCLMGDAAHPMMPDQSQGACMAIEDAACLGLVFSKEHFRGDIRKALEVYEEIRKPRATRVQVASQRARENIYERIGFSSNTNNEKYTVQNESNKLTIEEMNSYDMKEHAASVFGQRAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZQ2</accession>
    <name>B8LZQ2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_080670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477797.1">
        <property type="nucleotide sequence ID" value="XM_002477752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZQ2"/>
    <dbReference type="STRING" id="441959.B8LZQ2"/>
    <dbReference type="GeneID" id="8101376"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_080670"/>
    <dbReference type="eggNOG" id="ENOG502TCE4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_718004_0_0_1"/>
    <dbReference type="InParanoid" id="B8LZQ2"/>
    <dbReference type="OrthoDB" id="4493315at2759"/>
    <dbReference type="PhylomeDB" id="B8LZQ2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022698">
        <property type="entry name" value="OrsD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12013">
        <property type="entry name" value="OrsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED20834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="462" mass="53134" checksum="B2D9EFE99A70CB18" modified="2009-03-03" version="1">MSPSHLLAHLAKKHGHDYRIKTQIQRQQILEEMLKKPWIDPQKQSLQFPLSTSAPIPYLPIFQGYQCPSTTCPYVAVAKETMRIHILKHPEIPKNPRGPPRAFTHHIHIYPRVHCQRFFLSRVGSQYFAVTPSLSLINQELQTTPLSRANRIEAEVNTALAQSEAIIDTASNMIQSHRAPTEASPWLEMTRWGDYLCGYSFQQVALLGARPDPLQEPLLAEFASSVSRIIQQAHQSIQEDKINVFDQVQINSFLQHRRAWDRPLFIQLKKATYRSYEHLWQRLLSFVHRSTQPEQPVQLRHRLTPRQLQHLDEMVEYGIEVLAYQGQITRPLPTVIRGSTLAEAQALLDQACLRDLYESAVVGFLAVLGVDAEKRTFRDAYSYTPSLSGLVKMAQMLVVQEAIIQADEDQVEHPADALDEMRERFLIHGTRSPFAWITRLRTYGKKIQNTTTSLGYIYWSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZR8</accession>
    <name>B8LZR8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TSTA_080830</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477813.1">
        <property type="nucleotide sequence ID" value="XM_002477768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZR8"/>
    <dbReference type="FunCoup" id="B8LZR8">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LZR8"/>
    <dbReference type="GeneID" id="8101388"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_080830"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_351309_0_0_1"/>
    <dbReference type="InParanoid" id="B8LZR8"/>
    <dbReference type="OrthoDB" id="4529483at2759"/>
    <dbReference type="PhylomeDB" id="B8LZR8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0229">DNA integration</keyword>
    <keyword evidence="17" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="15" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="19">
        <location>
            <begin position="345"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="193"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="283"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EED20850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="801" mass="90654" checksum="027B51A92BA5B3D5" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZS4</accession>
    <name>B8LZS4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GRHL1/CP2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_080890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477819.1">
        <property type="nucleotide sequence ID" value="XM_002477774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZS4"/>
    <dbReference type="STRING" id="441959.B8LZS4"/>
    <dbReference type="GeneID" id="8101394"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_080890"/>
    <dbReference type="eggNOG" id="KOG4091">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1769343_0_0_1"/>
    <dbReference type="InParanoid" id="B8LZS4"/>
    <dbReference type="OrthoDB" id="9996779at2759"/>
    <dbReference type="PhylomeDB" id="B8LZS4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057520">
        <property type="entry name" value="GRHL1/CP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040167">
        <property type="entry name" value="TF_CP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037:SF20">
        <property type="entry name" value="PROTEIN GRAINYHEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037">
        <property type="entry name" value="TRANSCRIPTION FACTOR CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25416">
        <property type="entry name" value="GRHL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRHL1/CP2 C-terminal" evidence="1">
        <location>
            <begin position="45"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="147" mass="16478" checksum="65E86CE5BAF58C3C" modified="2009-03-03" version="1">MRWRDAISITQQVKIKKGTTGYTEALDLNPLCEPPVKRPPKPIACFYIRFPDEEKGDYYRALYLSERTVSNLTVKIAEKCKVNPGCIVRIVRVSLSGVETAVDDDIVQQVPEGQDMVAKVTEVSRLQTSTTSISTPPMATVEIRLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8M063</accession>
    <name>B8M063_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_083920</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478123.1">
        <property type="nucleotide sequence ID" value="XM_002478078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M063"/>
    <dbReference type="STRING" id="441959.B8M063"/>
    <dbReference type="GeneID" id="8101485"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_083920"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_11_1"/>
    <dbReference type="InParanoid" id="B8M063"/>
    <dbReference type="OMA" id="FIAYLMA"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="PhylomeDB" id="B8M063"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED21160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="460" mass="52882" checksum="315FB49BE037C3EB" modified="2009-03-03" version="1">MIVLPEVAQNLPFPHLLLAILSVIVTATAARIIYNLYFHPLHSYPGPLLGRATILYPILCELRGSLHLKVKEWHDEYGEVVRVAPNQLLYNSGRAWEKICGHRTSSNQSLFDKDQTFFFESPQGKHTMIGENGEKHRRLRRLLAHAFSDRALRAQEDILQSYVESLISQLRKRAATFDTNTVDMMRWFNYITFDIIGDLSFGDSFGLLEKGIWQRYLSSIFGLLQFGVRYRAIKRTFPLSWRFFLARWITPKDMREDRLYQHDLAQSKLTKRVSVDTGRQDFVHYMLKGSKDAIGPDGLSMDEIVNLSEFLMLAGSETTATVLSGMLYHLLQNPQCLSRLTSEIRSSFKSENDINLNSAAQLRYLHAVLEESMRIYPPVPNSLPRVTPEPGQIICDKFVPAGTSVGLHHYSSYHSSDNFFEPDAFHPERWLEGEDPRFRSDRKDAFHPFSHGPRNCLGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-09-13" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B8M082</accession>
    <name>B8M082_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_084110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478142.1">
        <property type="nucleotide sequence ID" value="XM_002478097.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478143.1">
        <property type="nucleotide sequence ID" value="XM_002478098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M082"/>
    <dbReference type="GeneID" id="8101504"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_084110"/>
    <dbReference type="HOGENOM" id="CLU_2224953_0_0_1"/>
    <dbReference type="InParanoid" id="B8M082"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007645144" evidence="1">
        <location>
            <begin position="20"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="106" mass="11091" checksum="FE291767473A82AA" modified="2009-03-03" version="1">MKVTLFALSLLSAIGLAAASPVAEIDLAERKACTYGIGEIFENVSCGVVEANPCVDPFTGKCDYPLGCMCVDDSTCCYGLAYVTQILHTPTGTNCLMACAAYIIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0I6</accession>
    <name>B8M0I6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_085140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478246.1">
        <property type="nucleotide sequence ID" value="XM_002478201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0I6"/>
    <dbReference type="STRING" id="441959.B8M0I6"/>
    <dbReference type="GeneID" id="8106120"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_085140"/>
    <dbReference type="eggNOG" id="ENOG502S2ZX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_4_0_1"/>
    <dbReference type="InParanoid" id="B8M0I6"/>
    <dbReference type="OrthoDB" id="4457643at2759"/>
    <dbReference type="PhylomeDB" id="B8M0I6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="107"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED21283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="446" mass="51206" checksum="A07B0A4581873325" modified="2009-03-03" version="1">MADYLLSQRGNRRVGENWVYNLVKRRPEIESKSSRKYNYERAKCEDPKIIQEYFDRVREVILEYGILPEDIYNFDETGFAMGLRATAKVITGSDRYARPKLLQPGNREWVTAIEAVNSIGWALPSYIIFKAKKYTRLGWFEDLPDDWKINISDNGWTTDKIGLEWLKTHFIPLTDGRTLGKYQMLILDGHGSHLTAEFDRTCTENNIIPPLDVGCFAVLKREYGRLIEQRMRLGFNHIDKIDFLTAFPKARTMAYKAQTVRNSFMVTGLVPFNPDRVYQQLTVRLKTPTPPPSRSSDTQSSCLQTPQNACQFKRQMTNTKKRISRHTRSSSEAIGEVFTRASKAYEMSINKLTIAQKELHDLRAAHEKEKQKHRRSKQQISHEQGITREEAQALVQGRVEASQAVTTAPAEPELPVCHPPVRRQFRCSGCGVAGHKITGCPNRIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0V3</accession>
    <name>B8M0V3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_089700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS41 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478696.1">
        <property type="nucleotide sequence ID" value="XM_002478651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0V3"/>
    <dbReference type="GeneID" id="8108059"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_089700"/>
    <dbReference type="eggNOG" id="ENOG502SCMV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087049_0_0_1"/>
    <dbReference type="InParanoid" id="B8M0V3"/>
    <dbReference type="OMA" id="GMWEDRR"/>
    <dbReference type="OrthoDB" id="18595at2759"/>
    <dbReference type="PhylomeDB" id="B8M0V3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039603">
        <property type="entry name" value="Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019083">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28235">
        <property type="entry name" value="PROTEIN FYV4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28235:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09597">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01238">
        <property type="entry name" value="IGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS41 SAM" evidence="6">
        <location>
            <begin position="15"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED21733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="214" mass="23529" checksum="30C47AE894E7C0B3" modified="2009-03-03" version="1">MPPVIPQPTPFVPDVPTFLSLIGREMSKHASKFTSWDSLFSLSSAELQDLGIEPARQRRYLLRQREKFKHGIYGPGGDLDVVVDGAAQLRVVEVPVGSSTKQGDEVNGTLPSASATLSPGMRKVLVNIAPDAEKYEYKPSDVIKKYAHMKIHRGSTVKGPYVQPLKGTNGSAVLIKATEGMWEDRRGHKVDGGERRRAEVRAKKRSAERRAANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1B7</accession>
    <name>B8M1B7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_090520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478776.1">
        <property type="nucleotide sequence ID" value="XM_002478731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1B7"/>
    <dbReference type="GeneID" id="8101543"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_090520"/>
    <dbReference type="HOGENOM" id="CLU_2147544_0_0_1"/>
    <dbReference type="InParanoid" id="B8M1B7"/>
    <dbReference type="PhylomeDB" id="B8M1B7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED21813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="112" mass="13230" checksum="5903FAFEFFB7184B" modified="2009-03-03" version="1">MTTQWLANDTPSYKLFGVPANTPEYRFRNEQQGTRLLAHEHDLFEQDQSGQQSQYVIFSNVDDKTYNRYFIYFHDHDRGSERTPQKRLALVKMTINELGVATEELNVNLMRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1Q3</accession>
    <name>B8M1Q3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucan endo-1,3-alpha-glucosidase agn1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_093860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479103.1">
        <property type="nucleotide sequence ID" value="XM_002479058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1Q3"/>
    <dbReference type="STRING" id="441959.B8M1Q3"/>
    <dbReference type="GeneID" id="8103714"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_093860"/>
    <dbReference type="eggNOG" id="ENOG502RZ85">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019141_1_0_1"/>
    <dbReference type="InParanoid" id="B8M1Q3"/>
    <dbReference type="OMA" id="DGHWPQD"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="PhylomeDB" id="B8M1Q3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877233" evidence="1">
        <location>
            <begin position="25"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="435" mass="47192" checksum="1263089E99043014" modified="2009-03-03" version="1">MKRTTSLFLSAVAATSSFTRLTTAQKLAFAHVVVGDTAAHTQSTWENDIKLAHAAGLDAFALNGGFPDSNVPKQIANAFAACESLANGFKLFVAFDYLGGGQPWPASEVVSILQNYSSSDCYLHYSNRPFVSTFEGTGNIDDWAPGGAVRGAVDVYFVPDWTSLGPTGIGAHLDNIDGFFSWDMWPNGASDMTADHDLAWVNAIGSEKTYMMGVSPWFFHSASGGTDWVWRGDDLWADRWNQVMTVDPQFVQVVTWNDWGEASYIGPFVTDNEVPSGSSVYVDNMPHESFRDFLPYYIATFKGDKFDISRDQMQYWYRLAPAAGGSECGVLGNNPDQGQTVVDVNSVVQDKVFFSALLTSPATVQVQIGNNPAVSYDGVAGINHWNQDFNGQTGVVKFSVVRNGATVKSNTGAEITASTSLANGCTNYNTWVGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1R1</accession>
    <name>B8M1R1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_093940</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479111.1">
        <property type="nucleotide sequence ID" value="XM_002479066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1R1"/>
    <dbReference type="STRING" id="441959.B8M1R1"/>
    <dbReference type="GeneID" id="8103722"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_093940"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006602_0_0_1"/>
    <dbReference type="InParanoid" id="B8M1R1"/>
    <dbReference type="OrthoDB" id="4217853at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="834"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="870"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="902"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="931"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="959"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="990"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1068"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1099"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1177"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1210"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1243"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="domain" description="HTH CENPB-type" evidence="12">
        <location>
            <begin position="60"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="836"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="692"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="692"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="733"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="743"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED22148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1280" mass="143942" checksum="49E3A9DC0AA860BA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1W8</accession>
    <name>B8M1W8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_085770</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CybS family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478309.1">
        <property type="nucleotide sequence ID" value="XM_002478264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1W8"/>
    <dbReference type="FunCoup" id="B8M1W8">
        <property type="interactions" value="243"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M1W8"/>
    <dbReference type="GeneID" id="8104542"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_085770"/>
    <dbReference type="eggNOG" id="KOG4097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096618_0_1_1"/>
    <dbReference type="InParanoid" id="B8M1W8"/>
    <dbReference type="OMA" id="SEGSYHW"/>
    <dbReference type="OrthoDB" id="18577at2759"/>
    <dbReference type="PhylomeDB" id="B8M1W8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03496">
        <property type="entry name" value="SQR_TypeC_CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] cytochrome b small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007992">
        <property type="entry name" value="CybS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05328">
        <property type="entry name" value="CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <note>ligand shared with SDHC</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <note>ligand shared with IP/SDHB</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007294"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED21346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="190" mass="20545" checksum="47200C1BD4CB10F4" modified="2009-03-03" version="1">MAAFIRPSSGAMLGQIMRVPASQSMLYNSAKSAPLAMTIIRQAQLNKTSQVTLFHSSAKREILTPLPQVIKGTMNDAAPVPHTSPSHGSYHWSFERLIAAGLVPLTIAPFVGGSLNPVMDSILAATLVLHSHIGFQALIIDYLPEKRVPKTLALFKWGLRAATLAVAVGLYEFETNDVGITEAIKRIWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2C9</accession>
    <name>B8M2C9_TALSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">TSTA_088290</name>
    </gene>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002478511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2C9"/>
    <dbReference type="STRING" id="441959.B8M2C9"/>
    <dbReference type="GeneID" id="8106926"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_088290"/>
    <dbReference type="eggNOG" id="ENOG502S1AV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048445_0_0_1"/>
    <dbReference type="InParanoid" id="B8M2C9"/>
    <dbReference type="OMA" id="HLWAVVQ"/>
    <dbReference type="OrthoDB" id="21214at2759"/>
    <dbReference type="PhylomeDB" id="B8M2C9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="304" mass="33820" checksum="06AE32C1F931F467" modified="2009-03-03" version="1">MPLDFPGLFSDAPTRESNRTTNSTSSAAMGNYMDNSPNVVNMANMSRQSMSPSPQQMNGVGGGGGGGVGNGVGGNNMGNNNNNMMMNGLPMNAGHQMDLNNLYDMVVEFSDILKNNREMTRGIVASAEEIMRRSTAEGTSPDINQVSGEISAARIAELERALARERRTVEALEREQFENTTLIGEFETSMGIMVEQIRNYCQNNNMYFLAQKKEYNALLQAERDAHLASRLDRDHWHAQTMRLAEMLRTAYRLRCEEDQAPTRIIQALQSEVRALRSAVGLEPEKPEEETGWEFLKDLETPAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3D6</accession>
    <name>B8M3D6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="8">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_095570</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>deamido-NAD(+) + L-glutamine + ATP + H2O = L-glutamate + AMP + diphosphate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="8"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479271.1">
        <property type="nucleotide sequence ID" value="XM_002479226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3D6"/>
    <dbReference type="FunCoup" id="B8M3D6">
        <property type="interactions" value="736"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M3D6"/>
    <dbReference type="GeneID" id="8105868"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_095570"/>
    <dbReference type="eggNOG" id="KOG2303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011884_2_0_1"/>
    <dbReference type="InParanoid" id="B8M3D6"/>
    <dbReference type="OMA" id="DETCHGI"/>
    <dbReference type="OrthoDB" id="2020662at2759"/>
    <dbReference type="PhylomeDB" id="B8M3D6"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07570">
        <property type="entry name" value="GAT_Gln-NAD-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000036">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000003">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="5"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED22308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="723" mass="81920" checksum="ABB75DC511EB935C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3R7</accession>
    <name>B8M3R7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stress protein DDR48, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_038650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481094.1">
        <property type="nucleotide sequence ID" value="XM_002481049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3R7"/>
    <dbReference type="STRING" id="441959.B8M3R7"/>
    <dbReference type="GeneID" id="8107907"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_038650"/>
    <dbReference type="eggNOG" id="ENOG502QUR8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_953677_0_0_1"/>
    <dbReference type="InParanoid" id="B8M3R7"/>
    <dbReference type="OMA" id="NTKRDND"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="258" mass="26356" checksum="CE0DC3B725D1BD1D" modified="2009-03-03" version="1">MSYNDNNDSYGSGSRSGGRSGGFGGNDDSYGSSGRGGSSYGSGNNDSYGSSNKSDSYGSSNNDSSYGSSRGGRDNSDSYGSNNNDSYGSGNKNSSYGSSNNDSYGSSNSDSYGSSNKSSSYGSSNNDSYGSSNNDSYGSSNKSSSYGSNNNDSNNDSYGSNKKSSSYGSSNDDSYGSSNNDSYGSSNKNSYGSGNNDSSYGSSRGGRDNSDSYGASNNDSYGSSNKNSSYGSSNNDSYGSSNNDSYGSSRGGRNNDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3Z3</accession>
    <name>B8M3Z3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_039360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481170.1">
        <property type="nucleotide sequence ID" value="XM_002481125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3Z3"/>
    <dbReference type="STRING" id="441959.B8M3Z3"/>
    <dbReference type="GeneID" id="8109274"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_039360"/>
    <dbReference type="eggNOG" id="ENOG502QTQ8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044876_1_1_1"/>
    <dbReference type="InParanoid" id="B8M3Z3"/>
    <dbReference type="OMA" id="YEWSLAC"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="PhylomeDB" id="B8M3Z3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF7">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="31"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED20736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="324" mass="35494" checksum="313D36D197189A40" modified="2009-03-03" version="1">MSLKSLTNTNEELNSAIKVTSNYITKVAIVGAGGNSGKFMTEALLRTDKHTVTAITRPDSKSKLPEGVIPKVVDYEKPETIVEALKGQDALVITLGAFALSNEVKLIVAADEAGVQWILPNEWSTYPGAHELIKDMLFYQMKISTGFWYEWSLPMPSAFGFDIINRSVTFFDDGEAKISVSTWPQVGRAVAALLGLPINAEGGRGDGSLESLNNKDVYINSFTINQTEMLESLLRVTGTKSEDWNITKVPADERLAEGLKEIQEGKHSGFAKKLYTRAFYPDGFGDFEHNEGTLNSLLGLPKEDLDEATKVAVERAGLPQWAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8M473</accession>
    <name>B8M473_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_040100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481250.1">
        <property type="nucleotide sequence ID" value="XM_002481205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M473"/>
    <dbReference type="STRING" id="441959.B8M473"/>
    <dbReference type="GeneID" id="8109769"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_040100"/>
    <dbReference type="eggNOG" id="ENOG502SVBM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051551_0_0_1"/>
    <dbReference type="InParanoid" id="B8M473"/>
    <dbReference type="OrthoDB" id="4526357at2759"/>
    <dbReference type="PhylomeDB" id="B8M473"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED20816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="300" mass="32190" checksum="AABACEA1F386F7F0" modified="2009-03-03" version="1">MARKGPGTDGPLQTALLESTSAAMTRASEGQKIFSPIAAFLDKHRSQTTGLAPHLLRALTALSDDLASVAQRHFSAYISSLEQSTYATITQYAPVKSTPTTHSKAQVKKPMPLVKQPLPDNQLFVRLPADHGARKMEAYTIYSSLQSQLNSNSSALKEVQATKTGFALCPSSPEALLTLKAQKEIISAFFVNYQIERSSRWVSKVGQILDGQYSLIPVNPTLLSLEISETTGLKPISISETATSAANPDTLSSSCYTFLALLLMLVTSLREQQLSNAYNAGNGIMHNPVPAPLNAGSVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4Q9</accession>
    <name>B8M4Q9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_025700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479688.1">
        <property type="nucleotide sequence ID" value="XM_002479643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4Q9"/>
    <dbReference type="STRING" id="441959.B8M4Q9"/>
    <dbReference type="GeneID" id="8107982"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_025700"/>
    <dbReference type="eggNOG" id="ENOG502RPYX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_712088_0_0_1"/>
    <dbReference type="InParanoid" id="B8M4Q9"/>
    <dbReference type="OrthoDB" id="4422004at2759"/>
    <dbReference type="PhylomeDB" id="B8M4Q9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED19254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="388" mass="45708" checksum="557AF1926A56AAEA" modified="2009-03-03" version="1">MRTRPSFPHHIYNDSDTALRYCRLIEDLAGQYPGYSYLDFYLNSENVQPRKEPYQIDLVQLSNGQSDAQFDINTFTDVNKLIDQVRKNDSHKLIILEDPTPEVIAHMGSELEIDPQFWADFLVGSFWFDSGKLRIDHRKEYKYFQDDSLLEKVWLLPTDARQQDHCCIRFVAQRALDRKDNAQMKKYKSLEKTHGITDGAETGPPNYANTVPEHCKLTLWNNFRNRRGNEKLMSQSSFKAYLDWQRRPQTALKSNASLREIINSQLNEQLNWKAFRNAAAYAPDYLLIDLCRLIASFWVAEIESQHLYLFWVEKFYQREITRQKQELTFQELFAYNWLSEKLNADDIELWSHRTATGCYSHSIKELSQCCDTQKPREAQLSTLKDTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5I2</accession>
    <name>B8M5I2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Crossover junction endonuclease MUS81</fullName>
            <ecNumber evidence="16">3.1.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSTA_031360</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 16">Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="15 16">Interacts with EME1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the XPF family.</text>
    </comment>
    <dbReference type="EC" id="3.1.22.-" evidence="16"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480310.1">
        <property type="nucleotide sequence ID" value="XM_002480265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5I2"/>
    <dbReference type="FunCoup" id="B8M5I2">
        <property type="interactions" value="196"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M5I2"/>
    <dbReference type="GeneID" id="8107747"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_031360"/>
    <dbReference type="eggNOG" id="KOG2379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014329_1_0_1"/>
    <dbReference type="InParanoid" id="B8M5I2"/>
    <dbReference type="OMA" id="ELGDAMW"/>
    <dbReference type="OrthoDB" id="5963188at2759"/>
    <dbReference type="PhylomeDB" id="B8M5I2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048257">
        <property type="term" value="F:3'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21036">
        <property type="entry name" value="WH_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20074">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000307">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000003">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000001">
        <property type="entry name" value="Putative Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033309">
        <property type="entry name" value="Mus81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047417">
        <property type="entry name" value="WHD_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047416">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451">
        <property type="entry name" value="CLASS II CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451:SF0">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21136">
        <property type="entry name" value="WHD_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 16" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 16" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="18">
        <location>
            <begin position="290"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="78"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00064962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU369042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EED19876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="616" mass="68892" checksum="1D010827FDC5081D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5Q5</accession>
    <name>B8M5Q5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_032080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480383.1">
        <property type="nucleotide sequence ID" value="XM_002480338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5Q5"/>
    <dbReference type="STRING" id="441959.B8M5Q5"/>
    <dbReference type="GeneID" id="8099821"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_032080"/>
    <dbReference type="eggNOG" id="ENOG502QTW2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021105_1_2_1"/>
    <dbReference type="InParanoid" id="B8M5Q5"/>
    <dbReference type="OMA" id="HYYLLIG"/>
    <dbReference type="OrthoDB" id="511599at2759"/>
    <dbReference type="PhylomeDB" id="B8M5Q5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056808">
        <property type="entry name" value="HTH_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168:SF1">
        <property type="entry name" value="ORC1-LIKE AAA ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24913">
        <property type="entry name" value="WHD_AAA_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="1">
        <location>
            <begin position="130"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="AAA protein C-terminal winged helix" evidence="2">
        <location>
            <begin position="379"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="546" mass="61987" checksum="62C70A9169DE167D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5R8</accession>
    <name>B8M5R8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acyl-coenzyme A diphosphatase SCS3</fullName>
            <ecNumber evidence="8">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">FIT family protein SCS3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SCS3</name>
        <name evidence="8" type="synonym">FIT2B</name>
        <name evidence="11" type="ORF">TSTA_032960</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization. Involved in phospholipid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65568"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:156554"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(9Z)-octadecenoyl-CoA + H2O = S-(9Z-octadecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:156553"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an acyl-CoA + H2O = an acyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132023"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>hexadecanoyl-CoA + H2O = S-hexadecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50032"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132018"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the FIT family. Fungal FIT2B/SCS3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="8"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480479.1">
        <property type="nucleotide sequence ID" value="XM_002480434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5R8"/>
    <dbReference type="FunCoup" id="B8M5R8">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M5R8"/>
    <dbReference type="GeneID" id="8105035"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_032960"/>
    <dbReference type="eggNOG" id="KOG3750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048143_0_0_1"/>
    <dbReference type="InParanoid" id="B8M5R8"/>
    <dbReference type="OMA" id="FTSWFFG"/>
    <dbReference type="OrthoDB" id="5579088at2759"/>
    <dbReference type="PhylomeDB" id="B8M5R8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03231">
        <property type="entry name" value="SCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019388">
        <property type="entry name" value="FIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046400">
        <property type="entry name" value="SCS3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10261">
        <property type="entry name" value="FIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED20045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="341" mass="37726" checksum="CB8E2C219913C791" modified="2009-03-03" version="1">MATSTAYPRSGSPSQTKRHTNAKTHPPATVLLIYPLTLILGSIYSVISPTARSSQNFGSSSSLTPTIATDINLPTSQRQHRPNPVNYFARKNNIFNLYFVKIGWVWITFAFLSLLLTRPYYTKAPGNLRGKRSVQALLRYAIVTCAWFLTTQWFFGPAIIDRTFVITGGKCERLPAAMANADDNTAWEDLKVVFTAAACKASGGLWKGGHDVSGHVFMLVLGSAFLALEVLGTSQSVSNGTAENSQVHDKCESDGEYTVVNEHSSTDPVARYSTKFVWVVIGLSWWMLFMTAIWFHTWLEKLSGLLISVSVVYITYFLPRSLPAWADIIGIPGFEPAVRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8M675</accession>
    <name>B8M675_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7514 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_024080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479509.1">
        <property type="nucleotide sequence ID" value="XM_002479464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M675"/>
    <dbReference type="GeneID" id="8109590"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_024080"/>
    <dbReference type="eggNOG" id="ENOG502SNYF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032499_1_0_1"/>
    <dbReference type="InParanoid" id="B8M675"/>
    <dbReference type="OMA" id="YWGTLIN"/>
    <dbReference type="OrthoDB" id="5420895at2759"/>
    <dbReference type="PhylomeDB" id="B8M675"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055936">
        <property type="entry name" value="DUF7514"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39611:SF2">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN DZ-HRGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39611">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN DZ-HRGP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24355">
        <property type="entry name" value="DUF7514"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7514" evidence="2">
        <location>
            <begin position="15"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="474" mass="53695" checksum="BFDD42699FBAE4EB" modified="2009-03-03" version="1">MENHNNSGENGNYWGTLINADKSPAPLLEELCIGLAQLMVKLDGGCGSTDLTPDKVARFYREVGGNYDTLFLETKGSALSFIYQSLGCFHTLQPTTNPFEPPSIPALLPTGFVRWLVINLLLCPDEHAQYLQEAVSRWDVPNPKGGTFPKVIPREAFPEAPDKDMCEWHENVSQRLQQDHAGHHSFRRSPPPEFVRYYSASTSARNYRHPFYDRSHQFHDGNPAPKSRNFSDHAEDIRYHRRRHSPDSREYRSRMFGIDPDVHSNSRTSSRNPSPRQTTSATGVPMRSKTTSARSRDIASERLASHYKHRPRNSSDSSNNDDDLLPPRRHASIDDHRHGRSTHLSPARPSRPPRRHSHDATSPVAEDSDTSTDDRSYRYHRDIAPKTKFREHIFDAPRPSQKASQPLPYEINPNVPNTPRVHVKYEGSPTEYRTSKRERGSSGSDRTRSSSDGSGGEANWKYSSHRAGGAKVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6H6</accession>
    <name>B8M6H6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_027350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479872.1">
        <property type="nucleotide sequence ID" value="XM_002479827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6H6"/>
    <dbReference type="STRING" id="441959.B8M6H6"/>
    <dbReference type="GeneID" id="8109654"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_027350"/>
    <dbReference type="eggNOG" id="ENOG502QRPA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_539890_0_0_1"/>
    <dbReference type="InParanoid" id="B8M6H6"/>
    <dbReference type="OMA" id="TWMRENA"/>
    <dbReference type="OrthoDB" id="5416037at2759"/>
    <dbReference type="PhylomeDB" id="B8M6H6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF6">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="486"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="4">
        <location>
            <begin position="302"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="342"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED19438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="505" mass="56252" checksum="E8F102E5017435C1" modified="2009-03-03" version="1">MSASVSSRRKGSRAARSKKPSSTPSKVPASHVPSTAVVGANPNVQLKSQTESGVQKKTRPDIQVGSELVKTQNGASSNKPNVFQFLQEGDSSSTSSDNSDSDSDDNDQDQEGLPALAQERPQPDRDTHSSYLISPESSFRASSPEQTFSVTSRDSIATDGGSVTSPDGSPATAYLRLVNKHNLQKAAQARSRRDAVQRQSPHRTDDEDDGHSDYSAPEDFYLAERMHYHQQKQQQQQQQHRSHIHRPHVHRQRNNRDHSGSRRGPSLSPGRSAGQLVTTETRDKNNKLVKTPTTKPRLSSGYALLASKLDSSTASPSQNPKYGDNSLIPVYRRFENMNHRILLHLQDEISQLEEELQMMDEYEAKHRASIAEKEGSEQLEPASRRMDVEAGRYSAFHARRLELVDRLTYKVNQYNDALTSYTKLSRMLPKASPKDIQTYRNWMNENTPIAKNETRFLDHDLDLVALNMAVPAVAAVGGQNQNNNSILYFIIGVLSTALLLPLLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6S8</accession>
    <name>B8M6S8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_033900</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480582.1">
        <property type="nucleotide sequence ID" value="XM_002480537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6S8"/>
    <dbReference type="FunCoup" id="B8M6S8">
        <property type="interactions" value="388"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M6S8"/>
    <dbReference type="GeneID" id="8097807"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_033900"/>
    <dbReference type="eggNOG" id="KOG1152">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004134_0_0_1"/>
    <dbReference type="InParanoid" id="B8M6S8"/>
    <dbReference type="OMA" id="MDESECR"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="PhylomeDB" id="B8M6S8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14004">
        <property type="entry name" value="STKc_PASK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000320">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000314">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057213">
        <property type="entry name" value="DUF7891"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF51">
        <property type="entry name" value="PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25421">
        <property type="entry name" value="DUF7891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="873"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="218"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="410"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="732"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="780"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="412"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="439"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="737"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="797"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED20148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1136" mass="125821" checksum="166A0A9A7DFF0234" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7C5</accession>
    <name>B8M7C5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_035710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480779.1">
        <property type="nucleotide sequence ID" value="XM_002480734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7C5"/>
    <dbReference type="STRING" id="441959.B8M7C5"/>
    <dbReference type="GeneID" id="8107521"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_035710"/>
    <dbReference type="eggNOG" id="KOG1121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_716065_0_0_1"/>
    <dbReference type="InParanoid" id="B8M7C5"/>
    <dbReference type="OMA" id="KINWDST"/>
    <dbReference type="OrthoDB" id="4364441at2759"/>
    <dbReference type="PhylomeDB" id="B8M7C5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED20345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="45665" checksum="4545DC55BDA96159" modified="2009-03-03" version="1">MAHNDWVDWWLQTNFGRKSKINWDSTRHAEIWDYYHQVAHSVDGALKVMCQRCGAILEHPYTVNSKTKGKIQYHGTSTMQKHLKTAGRLKSERGKRAEITEFLKNSAFIAITGYFIDADWVYREVLLGFKPLYGPHTSVNLSSVVLQTLMEHNLESRVFGLTTDNASNNKTLIPCLAHVIQLNFNQLLDRIKSRLAQANAQHQGREISYTLNKVRYLVIYVNASPQRRETFYNLQTSSVKLVPIQDVRTRWNSTFLMLRQAKRLRSIFTPFCAEYDCEEMLLQDEEWRQVDYLLSHYVFKIYNKLFEHLKQLMKQLRRKRAPWKQQMLHALEAGQTKLDEYYSQTDYIPGHIYAVSTMLAPVNKFKFFLTKDWDQKWRDIYRKSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7E3</accession>
    <name>B8M7E3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-rRNA-processing protein PNO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pre-rRNA-processing protein pno1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_035890</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480797.1">
        <property type="nucleotide sequence ID" value="XM_002480752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7E3"/>
    <dbReference type="FunCoup" id="B8M7E3">
        <property type="interactions" value="909"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M7E3"/>
    <dbReference type="GeneID" id="8107538"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_035890"/>
    <dbReference type="eggNOG" id="KOG3273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064992_0_2_1"/>
    <dbReference type="InParanoid" id="B8M7E3"/>
    <dbReference type="OMA" id="TPLRNNW"/>
    <dbReference type="OrthoDB" id="1932641at2759"/>
    <dbReference type="PhylomeDB" id="B8M7E3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042255">
        <property type="term" value="P:ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22391">
        <property type="entry name" value="KH-I_PNO1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055212">
        <property type="entry name" value="KH-I_PNO1_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="10">
        <location>
            <begin position="170"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED20363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="257" mass="28712" checksum="1232C2E0ED7592E4" modified="2009-03-03" version="1">MPAPTALLNKPQNAEDTALNSSLQEQNDDEVLIDASQNAPDFTVESIQEDNTEDVMHVDEEGRPVFTPAKDTPGVYRVEQRKVPIPPHRMTPLKTYWPKIYPPLVEHLKLQVRMNVKSRTVELRNSRLTTDPSALQRGADFVKAFALSFDVDDAIALLRLDDLYINSFEIKDVKTLSGDHLSRAIGRIAGHNGKTKFAIENATRTRVVLAGQKVHILGTFKNAKMAQEAIVSLILGSPPSKVYGNLRTIASRMKERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7U4</accession>
    <name>B8M7U4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_030860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480257.1">
        <property type="nucleotide sequence ID" value="XM_002480212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7U4"/>
    <dbReference type="STRING" id="441959.B8M7U4"/>
    <dbReference type="GeneID" id="8101765"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_030860"/>
    <dbReference type="eggNOG" id="ENOG502SQ0K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089360_0_0_1"/>
    <dbReference type="InParanoid" id="B8M7U4"/>
    <dbReference type="OrthoDB" id="2326446at2759"/>
    <dbReference type="PhylomeDB" id="B8M7U4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED19823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="27302" checksum="0564DAEE398513F9" modified="2009-03-03" version="1">MKVSADISALLTTDNDPVQHAEFKRQREICGWDYLDEDLQAFKEKQKKKLKSLFWIMIQLKAQAIGKKENSDSLPESNTLIQDATRGDTAGSSPSAGLFTVRAGHISLDSYADPPDPELALEDRSILTVQTFFILPEYRTGGVGRAAMDLVEVLATKEPYGGPRCHTLTLTTASKKYLEIDEPEWKGIWKKFGMDIPKFSAQIWYEKLGYVYWKEEPRYRSPTLDGSTLVVIASFMRKKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7V9</accession>
    <name>B8M7V9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_031030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480272.1">
        <property type="nucleotide sequence ID" value="XM_002480227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7V9"/>
    <dbReference type="STRING" id="441959.B8M7V9"/>
    <dbReference type="GeneID" id="8101780"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_031030"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_970365_0_0_1"/>
    <dbReference type="InParanoid" id="B8M7V9"/>
    <dbReference type="OMA" id="RHAYLYI"/>
    <dbReference type="OrthoDB" id="4807664at2759"/>
    <dbReference type="PhylomeDB" id="B8M7V9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039323">
        <property type="entry name" value="ANKRD_45/46/60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22677">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22677:SF4">
        <property type="entry name" value="USHER SYNDROME TYPE-1G PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="236"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="269"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED19838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="326" mass="35857" checksum="1B0436E815F41C7D" modified="2009-03-03" version="1">MNNQIHPQDAIEAVQRRRYQNRIAQRNHRKRQAELEQKRMRELDEKIESQRNQGSEPRVSVEGAYHGGAGIKPLNRPENIFPDQNTSDVPIPKPVGSQAEITQHQPRAFTESEPAWPPDNLASATSYMDIYGNMDETMPSLVLTSGFESQRRSIRSPTLRSLPSPSRIIKSSKTPQEGSNHLEGSKVFGGSGTFPSESGSQNLGKTALHISSERGSLGIVQFLLLSGVDVNGTDNCGRTALHYAAHAGHLDIVSQLLRGGADLDARDHEGRSPLHLAAHAECEEVIRFLAQEGADLDAAIGISRQMSSEDDDDLDLDYDNCETMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8M841</accession>
    <name>B8M841_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleotide-sugar transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_032580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480437.1">
        <property type="nucleotide sequence ID" value="XM_002480392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M841"/>
    <dbReference type="STRING" id="441959.B8M841"/>
    <dbReference type="GeneID" id="8099871"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_032580"/>
    <dbReference type="eggNOG" id="KOG3912">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025028_3_1_1"/>
    <dbReference type="InParanoid" id="B8M841"/>
    <dbReference type="OMA" id="FIYKHNV"/>
    <dbReference type="OrthoDB" id="29773at2759"/>
    <dbReference type="PhylomeDB" id="B8M841"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012404">
        <property type="entry name" value="UCP036436"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036436">
        <property type="entry name" value="UCP036436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED20003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="455" mass="50681" checksum="E359ECAE749500C3" modified="2009-03-03" version="1">MAREAIIPFLVTMMLVTGVCNTILNKYQDMQCVRNCDSLNPADHKLFEQPVIQTAQMFVGELGCFLVVLLSYLYTRFVASRTSSTAPLFAGGYRRIREDDHIPEYHDGEEEAEEYAEGVETNPNVVNNHPSDPTITKPIDETDAGGRRILNGWRILMLAAPACCDILGTTMMNAGLLFVAASIYQMTRGALVLFVGLFSVLFLRRRLYMYQWFALVIVVLGVGIVGLSGALFGHDQGVHDPESGISNAMSRFARDVNTTARTPEAVRVIIGVLLIAAAQIFTATQFVLEEWILEHYAMDPLNVVGWEGFFGLLVTTIGMVILHLAIGSTDAGRYGYFDLKEGWRQITHNRAIAVSSFLIMISIGGFNFFGLSVTRTVSATSRSTIDTSRTLFIWLVSLGLGWESFKWLQVLGFALLVYGTFLFNDIIRAPLKACLPARREFEHEELLPEEPIEHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B8M892</accession>
    <name>B8M892_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_036310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480839.1">
        <property type="nucleotide sequence ID" value="XM_002480794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M892"/>
    <dbReference type="GeneID" id="8101902"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_036310"/>
    <dbReference type="HOGENOM" id="CLU_127252_0_0_1"/>
    <dbReference type="InParanoid" id="B8M892"/>
    <dbReference type="OrthoDB" id="2976890at2759"/>
    <dbReference type="PhylomeDB" id="B8M892"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED20405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="136" mass="15658" checksum="EB183A545316DFE8" modified="2009-03-03" version="1">MDWSQLSQIHNILSKFNELTLLAVPIYYKLHDLLDKASKRKERFLDLDKDISLAVKEDTSDTYYTALILDPQIKGDLLLNKLEDKTTGREILQALRDSLHHDYSVATIELSLPTGQSLLEHNTKHSDVESQLLKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8M896</accession>
    <name>B8M896_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptide hydrolase</fullName>
            <ecNumber evidence="3">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_036350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480843.1">
        <property type="nucleotide sequence ID" value="XM_002480798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M896"/>
    <dbReference type="FunCoup" id="B8M896">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M896"/>
    <dbReference type="GeneID" id="8101906"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_036350"/>
    <dbReference type="eggNOG" id="KOG3946">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045003_0_0_1"/>
    <dbReference type="InParanoid" id="B8M896"/>
    <dbReference type="OMA" id="THWAYQK"/>
    <dbReference type="OrthoDB" id="3907302at2759"/>
    <dbReference type="PhylomeDB" id="B8M896"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03880">
        <property type="entry name" value="M28_QC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000074">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037457">
        <property type="entry name" value="M28_QC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040234">
        <property type="entry name" value="QC/QCL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283:SF6">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M28" evidence="5">
        <location>
            <begin position="105"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED20409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="377" mass="42400" checksum="0DA08F722C2A314D" modified="2009-03-03" version="1">MTSVPSLSQLSEETLKKLPRPGNDFDIHEGKLLAPILRTRIPGTPGSIAVLNHFNDFFKQTLPDWTVEFQNSSARTPISGNKEVPFVNFIASRDPPWASKGDVGRLTLVAHYDSKYEPKGFIGAIDSAAPCAMIMHAMRSIDAALTRKWDDMQAKGDGLDSGLDAHTGIQVLFLDGEEAFKTWTDSDSLYGSRSLAETWDETTHSAMSIFRTPLSSISLFMLLDLLGSKDPTIQSYFPTTHWAYQNLASLEGRLRNLKQFKSSPNYDIKSGHVDEPQWLVDAEKSEHLLKSWTAIQDDHVPFMRRGVDVLHIIDTPGRANFPTVWHTIHDDGEHLDLPTVEDWSMLITAFAAEWMELEGYFDAQDAAEKMYIRKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8A1</accession>
    <name>B8M8A1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aspartyl-tRNA synthetase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_036400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480848.1">
        <property type="nucleotide sequence ID" value="XM_002480803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8A1"/>
    <dbReference type="FunCoup" id="B8M8A1">
        <property type="interactions" value="631"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M8A1"/>
    <dbReference type="GeneID" id="8101911"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_036400"/>
    <dbReference type="eggNOG" id="KOG2411">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014330_2_1_1"/>
    <dbReference type="InParanoid" id="B8M8A1"/>
    <dbReference type="OMA" id="LCGWVDR"/>
    <dbReference type="OrthoDB" id="439710at2759"/>
    <dbReference type="PhylomeDB" id="B8M8A1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070146">
        <property type="term" value="P:mitochondrial aspartyl-tRNA aminoacylation"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAD-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001750">
        <property type="entry name" value="PRK00476.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="7">
        <location>
            <begin position="201"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED20414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="665" mass="73803" checksum="3B22D1FFC71A58F6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8G9</accession>
    <name>B8M8G9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_037030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480916.1">
        <property type="nucleotide sequence ID" value="XM_002480871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8G9"/>
    <dbReference type="GeneID" id="8100549"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_037030"/>
    <dbReference type="HOGENOM" id="CLU_180951_0_0_1"/>
    <dbReference type="InParanoid" id="B8M8G9"/>
    <dbReference type="OrthoDB" id="10303519at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED20482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="84" mass="9543" checksum="C0F465EE7A5ECBB0" modified="2009-03-03" version="1">MNAANLHSDNGIALPPYTEVNTDPDLEAPQQNHTRRTAVCRNLELVLIYSFALLVILVLLGVFAYEMYIQYRHAVTSRVKAQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8H3</accession>
    <name>B8M8H3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA repair helicase rad5,16, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_037070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480920.1">
        <property type="nucleotide sequence ID" value="XM_002480875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8H3"/>
    <dbReference type="STRING" id="441959.B8M8H3"/>
    <dbReference type="GeneID" id="8100553"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_037070"/>
    <dbReference type="eggNOG" id="KOG0389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_278505_0_0_1"/>
    <dbReference type="InParanoid" id="B8M8H3"/>
    <dbReference type="OMA" id="KFWQPVA"/>
    <dbReference type="OrthoDB" id="4227097at2759"/>
    <dbReference type="PhylomeDB" id="B8M8H3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF17">
        <property type="entry name" value="HELICASE-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="925"/>
            <end position="1080"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED20486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1135" mass="129782" checksum="9389D6B3B98E3236" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8Y5</accession>
    <name>B8M8Y5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_111240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481272.1">
        <property type="nucleotide sequence ID" value="XM_002481227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8Y5"/>
    <dbReference type="STRING" id="441959.B8M8Y5"/>
    <dbReference type="GeneID" id="8109804"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_111240"/>
    <dbReference type="eggNOG" id="KOG0351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004144_0_0_1"/>
    <dbReference type="InParanoid" id="B8M8Y5"/>
    <dbReference type="OMA" id="MARREWK"/>
    <dbReference type="OrthoDB" id="5153301at2759"/>
    <dbReference type="PhylomeDB" id="B8M8Y5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF154">
        <property type="entry name" value="RECQ HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="465"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="657"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="830"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="833"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED17280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1035" mass="117641" checksum="E4C5A40A927CFB53" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8M932</accession>
    <name>B8M932_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_111630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481319.1">
        <property type="nucleotide sequence ID" value="XM_002481274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M932"/>
    <dbReference type="STRING" id="441959.B8M932"/>
    <dbReference type="GeneID" id="8098818"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_111630"/>
    <dbReference type="eggNOG" id="KOG0502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1111964_0_0_1"/>
    <dbReference type="InParanoid" id="B8M932"/>
    <dbReference type="OMA" id="AFNGHEE"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="PhylomeDB" id="B8M932"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED17327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="250" mass="27362" checksum="6129F0C335DAB90C" modified="2009-03-03" version="1">MTEICVKYLLMNELVIDDERPVGSLLNYSAEHWVDHFRDVLSPKSGLLDLAEMPYYKDPKMNALHLAAFNGHEEILLRVALNKKEAIDQTDNSATSALQWACLRGHSRIVERLIKKGANINAQGGYYSNAVQAASTKGHLKIVQHLLENGADINAQGGAYGNSLQAACAGGHIQIVQHLFENGADINAQGGIYGYALYAASAKGYLKIVQQLLDKGANINSEDRYYRHALHSASVGEYLEIVQLLMGKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9Q2</accession>
    <name>B8M9Q2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cysteine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSTA_118240</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="4"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482046.1">
        <property type="nucleotide sequence ID" value="XM_002482001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9Q2"/>
    <dbReference type="FunCoup" id="B8M9Q2">
        <property type="interactions" value="933"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M9Q2"/>
    <dbReference type="GeneID" id="8099748"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_118240"/>
    <dbReference type="eggNOG" id="KOG2007">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013528_3_1_1"/>
    <dbReference type="InParanoid" id="B8M9Q2"/>
    <dbReference type="OMA" id="FHNDMKS"/>
    <dbReference type="OrthoDB" id="438179at2759"/>
    <dbReference type="PhylomeDB" id="B8M9Q2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000228">
        <property type="entry name" value="Cysteinyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000186">
        <property type="entry name" value="Putative Cysteinyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1910">
        <property type="entry name" value="Cysteine-tRNA ligase, C-terminal anti-codon recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="14">
        <location>
            <begin position="74"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Cysteinyl-tRNA synthetase class Ia DALR" evidence="15">
        <location>
            <begin position="552"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF09190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EED18054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="828" mass="93446" checksum="8BE41DBBD03A74F6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9R5</accession>
    <name>B8M9R5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">20S-pre-rRNA D-site endonuclease NOB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_118360</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NOB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482059.1">
        <property type="nucleotide sequence ID" value="XM_002482014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9R5"/>
    <dbReference type="FunCoup" id="B8M9R5">
        <property type="interactions" value="1041"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M9R5"/>
    <dbReference type="GeneID" id="8099760"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_118360"/>
    <dbReference type="eggNOG" id="KOG2463">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024666_2_0_1"/>
    <dbReference type="InParanoid" id="B8M9R5"/>
    <dbReference type="OMA" id="GYELECE"/>
    <dbReference type="OrthoDB" id="446759at2759"/>
    <dbReference type="PhylomeDB" id="B8M9R5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09876">
        <property type="entry name" value="PIN_Nob1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000026">
        <property type="entry name" value="20S-pre-rRNA D-site endonuclease NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.10">
        <property type="entry name" value="Nin one binding (NOB1), Zn-ribbon-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017117">
        <property type="entry name" value="Nob1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036283">
        <property type="entry name" value="NOB1_Zf-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014881">
        <property type="entry name" value="NOB1_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08772">
        <property type="entry name" value="Zn_ribbon_NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037125">
        <property type="entry name" value="D-site_20S_pre-rRNA_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144206">
        <property type="entry name" value="NOB1 zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ribonuclease PIN" evidence="11">
        <location>
            <begin position="14"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Nin one binding (NOB1) Zn-ribbon-like" evidence="10">
        <location>
            <begin position="292"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="118"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="415"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037125-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED18067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="442" mass="48507" checksum="B6C37ED7EA10AA7B" modified="2009-03-03" version="1">MAEQPAPTKPVHTIVLDAGPILKNVPPLSTLLAQAEDLVTTPAVVGEIRDPVARSRFETLYLPFLKQRSPSPKSVQVISEFARKTGDRAVLSKVDIEVLALAYEIECEKNGGDWRLRSVPGQKRVNGKPPVKEGESAAENTTAQEGVDKATEETKEKEEINGETSTADVSKVAEELAETTIKDDTTGSNEGTEAVPETTTPIVGTTVEDGTEDISVEIVEDEEEGEDSDGGGEWITPSNIKKKQARDEEAGLSATPEPKVMQVATMTTDFACQNVLLQMNLNLLSTTTLQRIRHLRTFVKRCHACFSITKEMNKQFCPRCGKDTLTRVSCSTDANGQFKLHLKKNMQWNNRGNVFSVPKPIHGSANGKWKGGGGQGGWGTGLILAEDQKEYVRAVTDEKRQQRRERDLMDEDYLPGILTGERHRSGGRVKVGAGRNVNSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MA17</accession>
    <name>B8MA17_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_120900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482338.1">
        <property type="nucleotide sequence ID" value="XM_002482293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MA17"/>
    <dbReference type="FunCoup" id="B8MA17">
        <property type="interactions" value="1016"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MA17"/>
    <dbReference type="GeneID" id="8100074"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_120900"/>
    <dbReference type="eggNOG" id="KOG3295">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075696_1_1_1"/>
    <dbReference type="InParanoid" id="B8MA17"/>
    <dbReference type="OMA" id="IQKNHFR"/>
    <dbReference type="OrthoDB" id="10264538at2759"/>
    <dbReference type="PhylomeDB" id="B8MA17"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_eL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018256">
        <property type="entry name" value="Ribosomal_eL13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01104">
        <property type="entry name" value="RIBOSOMAL_L13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED18346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="226" mass="25527" checksum="09A53422E8B9487E" modified="2009-03-03" version="1">MAIKHNNVIPNTHFHKDWQRRVRVHFDQPGRKHRRRQARLSKAAAVAPRPVDKLRPVVRCPTIKYNRRSRAGRGFTLQELKEAGIPRKLAPTIGISVDHRRKNVSQESLAANVARLQEYKSRLILFPRKSGQYKKLDSSAEDVAAATKAFSADGKVEGYTTRVSSALPVKNISAAEAVTEISRSDLPEGEKAAYRRLREARAEARYRGAREKRAKDKAEAEEASKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAW0</accession>
    <name>B8MAW0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UPF0047 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_115920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481792.1">
        <property type="nucleotide sequence ID" value="XM_002481747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAW0"/>
    <dbReference type="STRING" id="441959.B8MAW0"/>
    <dbReference type="GeneID" id="8099619"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_115920"/>
    <dbReference type="eggNOG" id="KOG3267">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096980_0_0_1"/>
    <dbReference type="InParanoid" id="B8MAW0"/>
    <dbReference type="OMA" id="TWQGIFF"/>
    <dbReference type="OrthoDB" id="10255963at2759"/>
    <dbReference type="PhylomeDB" id="B8MAW0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047_YjbQ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YJBQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615:SF8">
        <property type="entry name" value="UPF0047 PROTEIN C4A8.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01314">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="144" mass="16274" checksum="D64E9DB173AEE95E" modified="2009-03-03" version="1">MSWFQKQFTLPSRSRGSYLITDTVINELPEIRDYKCGLLNLFIQHTSCALSLNENWDEDVRADMSDALDRIAPYDKKGNLYRHSAEGEDDMPAHIKSALVGASVTIPITNGRLATGTWQGIWYLEFRASKHTRKVVATIQGEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MB12</accession>
    <name>B8MB12_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Presequence translocated-associated motor subunit PAM17, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_124370</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAM17 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482705.1">
        <property type="nucleotide sequence ID" value="XM_002482660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MB12"/>
    <dbReference type="STRING" id="441959.B8MB12"/>
    <dbReference type="GeneID" id="8098388"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_124370"/>
    <dbReference type="eggNOG" id="ENOG502S1B1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_479941_0_0_1"/>
    <dbReference type="InParanoid" id="B8MB12"/>
    <dbReference type="OrthoDB" id="5970083at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013875">
        <property type="entry name" value="Pam17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021:SF1">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08566">
        <property type="entry name" value="Pam17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="472"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED18713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="568" mass="62624" checksum="229FD73EF0F1FEB1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBK2</accession>
    <name>B8MBK2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF159 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_116560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481858.1">
        <property type="nucleotide sequence ID" value="XM_002481813.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481859.1">
        <property type="nucleotide sequence ID" value="XM_002481814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBK2"/>
    <dbReference type="FunCoup" id="B8MBK2">
        <property type="interactions" value="619"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MBK2"/>
    <dbReference type="GeneID" id="8102048"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_116560"/>
    <dbReference type="eggNOG" id="KOG2618">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035990_0_3_1"/>
    <dbReference type="InParanoid" id="B8MBK2"/>
    <dbReference type="OMA" id="GMWTTMK"/>
    <dbReference type="OrthoDB" id="2111841at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106300">
        <property type="term" value="P:protein-DNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="entry name" value="SOS response associated peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604:SF0">
        <property type="entry name" value="ABASIC SITE PROCESSING PROTEIN HMCES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="DC12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="BB1717-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="288"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="292"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED17866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="425" mass="48643" checksum="219D78E665F18FD8" modified="2009-03-03" version="1">MCGRYALGVRMFFVRRRMQEQGMQVDEAPEDDEIRETYNFAPGYYGAVYRADSPDHGFDDEPPPHDQDSENISSSPAEKDGEEEKTIKYKLQKMRWGLIPFWTKRQPDYGSMMRTINCRADSLAENKGMWTSMKRKKRCVIICQGFYEWLKKGPGGKEKVPHFIKRKDGDLMYFAGLWDCVQYEDSNEKLYTYTIITTDSNPYLKFLHDRMPVILDPASKEMQAWLDPRQTTWNKELQSILKPYEGELECYPVSKEVGKVGNNSAEFLVPVNSRENKSNIANFFANAGAKKKKEEEEKGEEAAKGADKEEEKGRIRNETDPEVRETVDAEWTEDNAPKPVPRSDRDKKTSPQSGLKRKFSTDESPPVTKRQKSLSPVKERDTAVGGRKMKSATSSSPSKPKSIRNKRAAAAATTGSQRITDFFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCD3</accession>
    <name>B8MCD3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal specific transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_123090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482571.1">
        <property type="nucleotide sequence ID" value="XM_002482526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCD3"/>
    <dbReference type="STRING" id="441959.B8MCD3"/>
    <dbReference type="GeneID" id="8108224"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_123090"/>
    <dbReference type="eggNOG" id="ENOG502S5RK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008828_1_3_1"/>
    <dbReference type="InParanoid" id="B8MCD3"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="PhylomeDB" id="B8MCD3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="298"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="608"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="416"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="880"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED18579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1012" mass="114126" checksum="6E040A400A378EC0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCH9</accession>
    <name>B8MCH9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_125120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482786.1">
        <property type="nucleotide sequence ID" value="XM_002482741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCH9"/>
    <dbReference type="GeneID" id="8100291"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_125120"/>
    <dbReference type="eggNOG" id="ENOG502SVX1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039063_0_0_1"/>
    <dbReference type="InParanoid" id="B8MCH9"/>
    <dbReference type="OMA" id="QHVENYY"/>
    <dbReference type="OrthoDB" id="5421765at2759"/>
    <dbReference type="PhylomeDB" id="B8MCH9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED18794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="384" mass="41293" checksum="370267C6F0FA4D1E" modified="2009-03-03" version="1">MATASTISSKAVVPSSSHVVPATTNLPDPNIGSTTPGRGKGLSNGTLAGAIVGSIAGTALLVFLAAWLFFRKSQNTRSGFRRYEGGEYTTAAMEKAGRSDHPDQNRLPSAELKATGANDQIFSGNTGEKWLLTSSLSRYIPEPASDETVVKHALTFFDQASLHVDNYYSQTLSVSSLLSSGKTSQISDFGTPYLPGSLTSLLENSTTRRLIITHTLVHSLLQAIQPHSAARESLLPLPFTIGPLKQVQQAINSDKELSQAFYTWRMLTAYLSQLATPEAAKRNLAVQDTAVHKFVETFTSSFAPYADSSHSRGNRVRHLGTVTTTAADLGRWLFGQPCTFEFVYTSPAGSGEIVVLPAIVKVLDEEGQRLANKVILCEAVTAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCP2</accession>
    <name>B8MCP2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Neurolysin, putative</fullName>
            <ecNumber evidence="9">3.4.24.37</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_126520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.37" evidence="9"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482936.1">
        <property type="nucleotide sequence ID" value="XM_002482891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCP2"/>
    <dbReference type="GeneID" id="8099079"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_126520"/>
    <dbReference type="eggNOG" id="KOG2089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001805_1_1_1"/>
    <dbReference type="InParanoid" id="B8MCP2"/>
    <dbReference type="OMA" id="EPMLKNR"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="PhylomeDB" id="B8MCP2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
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    </dbReference>
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        <property type="entry name" value="Endopeptidase. Chain P, domain 1"/>
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        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
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    </dbReference>
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    <keyword evidence="4 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="8">
        <location>
            <begin position="194"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED18944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="685" mass="78511" checksum="74B49102FBA62E62" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCS5</accession>
    <name>B8MCS5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_126850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482969.1">
        <property type="nucleotide sequence ID" value="XM_002482924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCS5"/>
    <dbReference type="GeneID" id="8099112"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_126850"/>
    <dbReference type="HOGENOM" id="CLU_1696676_0_0_1"/>
    <dbReference type="InParanoid" id="B8MCS5"/>
    <dbReference type="OMA" id="GEIMANM"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="PhylomeDB" id="B8MCS5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED18977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="155" mass="17882" checksum="772A3926C9FB5DFF" modified="2009-03-03" version="1">MYLIAPDLSIDLVELPETVPGNNSFCDHELFMFRPATRKITNFTIEIVSDPVCSWCYIGKKKLDNAIKIHQSSQPDNPFIKIWKPFYVKPHSSEIGKQLFSLIHLKTEVPILPNFRKQHGEIMANMMIERVRIIGADISIEFKFSGRTGRTHETH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCZ9</accession>
    <name>B8MCZ9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_113510</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481517.1">
        <property type="nucleotide sequence ID" value="XM_002481472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCZ9"/>
    <dbReference type="GeneID" id="8101663"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_113510"/>
    <dbReference type="eggNOG" id="KOG0762">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_16_1_1"/>
    <dbReference type="InParanoid" id="B8MCZ9"/>
    <dbReference type="OMA" id="WVTATPF"/>
    <dbReference type="OrthoDB" id="193856at2759"/>
    <dbReference type="PhylomeDB" id="B8MCZ9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF10">
        <property type="entry name" value="SLC (SOLUTE CARRIER) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="97"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="191"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED17525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="311" mass="34119" checksum="6CBEA952CE74745B" modified="2009-03-03" version="1">MSSDFVAGYVSGAVGILIGNPLDLVKVRLQARRGDESLRASSQGHGYFETKSSLIKGAAAPILGYGALNALLFVAYNRSLKFLDPSVINPTNLDANVSLMNIWLAGAAGGMASWVISSPTELVKCRTQLSRNQNISSWTVFRDILRVQGVRGLYFGGLITSIRDSVGYGFYFWSYELCKRSLSSLDDSSQQEALKVLLCGGVAGIITWASVFPLDVVKTRLQAQPFIAHTVSEVPDFQRRLLPPTSSSRPRILNSLEIARDAYRSEGFSVFFRGLGICSVRAFIVNAAQWAVYEWLMKEFNRASTAPHVSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8MD55</accession>
    <name>B8MD55_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HRQ family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_113950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481572.1">
        <property type="nucleotide sequence ID" value="XM_002481527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MD55"/>
    <dbReference type="STRING" id="441959.B8MD55"/>
    <dbReference type="GeneID" id="8109157"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_113950"/>
    <dbReference type="eggNOG" id="ENOG502QQRB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025462_3_0_1"/>
    <dbReference type="InParanoid" id="B8MD55"/>
    <dbReference type="OMA" id="QFICARY"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="PhylomeDB" id="B8MD55"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED17580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="56877" checksum="103895D16A53A792" modified="2009-03-03" version="1">MTFHIWSLQWLVGLALLGTTVIYVAFTRVRGRSILSRARKTSTSKTPPRSLSPEKKPSASSGAPDTCYSDALPPPRREAMLNMKSKIPKTASKHISEEHILKNILPMTQNYETASDGLYTSMGFSVKEIKEMGDFLDYSALSGVPLPNAHQEFKIEKALPRPYRPFRWNYHQTMSLKKLETDWWVELENTYKERIAQRKALYEKHGKDVLDWMPGSELACKELMEMVLQFICARYPQYFSIRDDRILVNKILETEQDIRSKQPLEILMDNVPEDFAITLRDDKTGYYVFRAGVICSSLGWNVGTKIGLQLHEIHAPVPDYKEKMRFSMDRFFTKMPADKPIQRGSWGLEIDKPLYMPAGHPHEQHRLSQKPDLALKDCFLRVDWQTLRRLPISGGIVFNFKAIFTPVQEFRDEPKIPALVAKILRNGKENLMKYKSTWHVEHVVLPALDKWNKEQEDSGAIERNWEVTTLDEDPWYKGWEDKWHRQQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDQ2</accession>
    <name>B8MDQ2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="14">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSTA_120300</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="14"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482273.1">
        <property type="nucleotide sequence ID" value="XM_002482228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MDQ2"/>
    <dbReference type="FunCoup" id="B8MDQ2">
        <property type="interactions" value="503"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MDQ2"/>
    <dbReference type="GeneID" id="8100014"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_120300"/>
    <dbReference type="eggNOG" id="KOG2124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007676_0_0_1"/>
    <dbReference type="InParanoid" id="B8MDQ2"/>
    <dbReference type="OMA" id="QSYFHRE"/>
    <dbReference type="OrthoDB" id="2748310at2759"/>
    <dbReference type="PhylomeDB" id="B8MDQ2"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000015">
        <property type="entry name" value="GPI ethanolamine phosphate transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="463"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="554"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="590"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="618"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="642"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="673"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="707"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="739"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="763"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="826"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="865"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="900"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="931"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="15">
        <location>
            <begin position="453"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EED18281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="994" mass="110763" checksum="0395817EB591414F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDW4</accession>
    <name>B8MDW4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Monocarboxylate permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_011510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483275.1">
        <property type="nucleotide sequence ID" value="XM_002483230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MDW4"/>
    <dbReference type="GeneID" id="8104992"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_011510"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="InParanoid" id="B8MDW4"/>
    <dbReference type="OMA" id="CANGSFF"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="PhylomeDB" id="B8MDW4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF305">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED16041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="407" mass="42644" checksum="1159A51F11CDF171" modified="2009-03-03" version="1">MEIRQENIVLQAIPESTTTIINNQAGNDAFAPASSAHPPVDAIPDGGYGWTIVFACFIQTSWVNAWAGSWGIFQSSLIQTTLKTIPTSTLTFVGSLGLVLTVSLGLVCIRLSRLIGARWAVLIGTLLFGASNIVGGLAVNSLGGLFVSGVLYGLGGALMYTMSNSLPVQWFSTRLGTANGLVKLGGGIGATIMVIVVQLLIERVEISWTFHIMGLMSLASGVPAALLIKERAPSYYGPSIDLSTFRRLPFSCLFAAGAIGVFPLYVPAFFLPFGSTNTLLFAMVLNSVTMFAIWPVSSTLALLLLFAALNGLANGAFFVTMPTAVGRFLGPGQAAVGIGMAVTGWSVGDFLGAPIAGFLIQATGANQAKTIGPYKPAIFYAAGTALVSTVFVLVARLKMDGSPFRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8ME24</accession>
    <name>B8ME24_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_012100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HscB family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483335.1">
        <property type="nucleotide sequence ID" value="XM_002483290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ME24"/>
    <dbReference type="FunCoup" id="B8ME24">
        <property type="interactions" value="329"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8ME24"/>
    <dbReference type="GeneID" id="8104058"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_012100"/>
    <dbReference type="eggNOG" id="KOG3192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068529_1_0_1"/>
    <dbReference type="InParanoid" id="B8ME24"/>
    <dbReference type="OMA" id="TVELKYW"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="PhylomeDB" id="B8ME24"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.20">
        <property type="entry name" value="HscB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004640">
        <property type="entry name" value="HscB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036386">
        <property type="entry name" value="HscB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009073">
        <property type="entry name" value="HscB_oligo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00714">
        <property type="entry name" value="hscB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021:SF15">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07743">
        <property type="entry name" value="HSCB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47144">
        <property type="entry name" value="HSC20 (HSCB), C-terminal oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="66"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED16101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="252" mass="28515" checksum="3CDC36F14B0BB019" modified="2009-03-03" version="1">MQGAITLRPQRLMSSVRARGPLSYSPSRPICLLCQQKQFTSNTLKLASQRQKVNPSSNPLTPDITNHYTIFPNTLPQGPPPNSSFSFDTSALRREFLQLQNAFHPDKFPQGPEKQRSEALSSRINDAYRTLIDPLSRAQYLLSHFHGIDVLAEDSAQTHPLDSETLMEVMDVQEAVEELSSAPVAEAEATVARLREENATRIEETVDKLHKAFDSGDIETAQRETVRLRFWYSLRDGLREWEHGHGAIRIVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8ME59</accession>
    <name>B8ME59_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_015710</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483720.1">
        <property type="nucleotide sequence ID" value="XM_002483675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ME59"/>
    <dbReference type="FunCoup" id="B8ME59">
        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8ME59"/>
    <dbReference type="GeneID" id="8106310"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_015710"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010228_0_1_1"/>
    <dbReference type="InParanoid" id="B8ME59"/>
    <dbReference type="OMA" id="RNADLIH"/>
    <dbReference type="OrthoDB" id="1405469at2759"/>
    <dbReference type="PhylomeDB" id="B8ME59"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000306">
        <property type="entry name" value="IKS protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000699">
        <property type="entry name" value="Probable serine/threonine-protein kinase iksA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF138">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE IKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="155"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="477"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="483"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED16486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="731" mass="82235" checksum="99BB59551083B961" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8ME81</accession>
    <name>B8ME81_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTPase activating protein for Arf, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_015920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483742.1">
        <property type="nucleotide sequence ID" value="XM_002483697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ME81"/>
    <dbReference type="STRING" id="441959.B8ME81"/>
    <dbReference type="GeneID" id="8106365"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_015920"/>
    <dbReference type="eggNOG" id="KOG0703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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</entry>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
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        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED16511.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="620" mass="70443" checksum="63D53BFE51227946" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8MF47</accession>
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        <recommendedName>
            <fullName evidence="10">Small nuclear ribonucleoprotein G</fullName>
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        <name evidence="12" type="ORF">TSTA_012540</name>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
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        <text evidence="10">Plays a role in pre-mRNA splicing.</text>
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    <comment type="subunit">
        <text evidence="9">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
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        <property type="protein sequence ID" value="EED16146.1"/>
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        <property type="nucleotide sequence ID" value="XM_002483335.1"/>
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    <dbReference type="HOGENOM" id="CLU_076902_10_1_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:catalytic step 2 spliceosome"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0034719">
        <property type="term" value="C:SMN-Sm protein complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="C:U2 snRNP"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:U2-type prespliceosome"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:U4 snRNP"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:U5 snRNP"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:7-methylguanosine cap hypermethylation"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Small nuclear ribonucleoprotein G"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034098">
        <property type="entry name" value="Sm_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF2">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037188">
        <property type="entry name" value="U6_snRNA_Lsm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="3"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED16146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="77" mass="8718" checksum="633F41ECC3173D8D" modified="2009-03-03" version="1">MPQAQPELKKYMEKRLFVQLNGNRKVIGILRGYDVFMNIVLDDAVEEKPDGGKDRLGMVVIRGNSVVMLEALERIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8MF62</accession>
    <name>B8MF62_TALSN</name>
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        <recommendedName>
            <fullName evidence="4">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_012680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
            <location evidence="1 4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RPF2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EED16161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002483350.1"/>
    </dbReference>
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        <property type="interactions" value="983"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MF62"/>
    <dbReference type="GeneID" id="8108144"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_012680"/>
    <dbReference type="eggNOG" id="KOG3031">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049783_0_0_1"/>
    <dbReference type="InParanoid" id="B8MF62"/>
    <dbReference type="OMA" id="VGLKPMF"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="PhylomeDB" id="B8MF62"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="28"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="250"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED16161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="357" mass="40514" checksum="D7DBEBDC9CB63E99" modified="2009-03-03" version="1">MLREVKPKNPRTARLLKKKEPQLIESSKRTLLLHGTKCPLPLNTLLKTIHGLTNPNSVLFHKKNDNIHPFESTESIEFLADKNECGIVVYGSSNKKRPNCMTLTRIYNKKVLDMFELLLLPPADGETIPPPNALKLEIGIGMKPMMLFAGSIWEDATSRTYAMIKSVLLDMFKGEETDKIDVEGLQYLMMVGAEEPAEAGLLPIIHLRWYKIRTRRSGHKLPRVELDEVGPKFDFRIGRVRNADPDVMKEAMKQGKRPNEEARTKKNITMDSIGDKVGRVHLGKQDLSNLQTRKMKGLKRRAGVDTDSEEDDDDEPSNYGSDVSEEITFVDEDEPSDVDMMDVDEEEKGRSKKPRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MG46</accession>
    <name>B8MG46_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_010310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483147.1">
        <property type="nucleotide sequence ID" value="XM_002483102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MG46"/>
    <dbReference type="GeneID" id="8105670"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_010310"/>
    <dbReference type="eggNOG" id="ENOG502SJR6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013296_2_1_1"/>
    <dbReference type="InParanoid" id="B8MG46"/>
    <dbReference type="OMA" id="CLARASH"/>
    <dbReference type="OrthoDB" id="4898680at2759"/>
    <dbReference type="PhylomeDB" id="B8MG46"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF53">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="335"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="42"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED15913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="694" mass="78366" checksum="77F179318EBEA7A3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGT8</accession>
    <name>B8MGT8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycoside hydrolase family 76 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_014150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483553.1">
        <property type="nucleotide sequence ID" value="XM_002483508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGT8"/>
    <dbReference type="STRING" id="441959.B8MGT8"/>
    <dbReference type="GeneID" id="8099214"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_014150"/>
    <dbReference type="eggNOG" id="ENOG502S9QC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028686_0_0_1"/>
    <dbReference type="InParanoid" id="B8MGT8"/>
    <dbReference type="OrthoDB" id="9984024at2759"/>
    <dbReference type="PhylomeDB" id="B8MGT8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF1">
        <property type="entry name" value="ENDO MANNANASE, GH76 FAMILY (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED16319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="26062" checksum="1601ECC8A873C95B" modified="2009-03-03" version="1">MAGDGVELQVLFYDDEGWWGIAWLAVYNLTENPDYLNLAISIYNDIQGGVDMPCGGLWWDKSKGYIASIANELYIALAAGLANHVSSDQAQSYLDAATIGWDWFTNIGVVGDDWLVVDGVDTSSCEPTGAKWSYNQIAAVELAQATGNSSYLDYAGNISNATTAINGTFPDANGVIKDCTGGCDIQSDMFKGSLFRGLRQLQLADPHDNWKNFIETNAQSLWNYALKVTNGGECNTGMMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHD1</accession>
    <name>B8MHD1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(II)2Cys6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_021670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484344.1">
        <property type="nucleotide sequence ID" value="XM_002484299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHD1"/>
    <dbReference type="STRING" id="441959.B8MHD1"/>
    <dbReference type="GeneID" id="8098433"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_021670"/>
    <dbReference type="eggNOG" id="ENOG502S89D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036096_1_0_1"/>
    <dbReference type="InParanoid" id="B8MHD1"/>
    <dbReference type="OMA" id="VMQIVNH"/>
    <dbReference type="OrthoDB" id="3469225at2759"/>
    <dbReference type="PhylomeDB" id="B8MHD1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED17110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="40556" checksum="018AC253EA69AFD0" modified="2009-03-03" version="1">MALTDATAFQLCMANAAMFMAQRKQPDTFQYEKCSEALEYYGQCLRQVTKRLECRDDCTSEGVIVTVLGLICHDIYVGSWTRWETHMKGLHRIIQVRGGYKNIDSNLALWASWYDVLGSATHDTYPHFPEYMNNLPSRLPGRTPLLEHIICKLMHENNAAMCPVINALDRIKVIADIVNARHHEPEFWRREDDLSPLHTIGPVAHILLSTPRLDLQTDGTIDSAKLFCEMTRLCMLILLAALKRLYSFALDEIELTTLTAKFSLVLSIYWRSPSLYQPDDALQSLQLWSILIVAALQPFVDRTLYVAEIRRCMHHMGIQSATDALQRSRDIAWVDVVCGMGAENETLLTAIDNAAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHE2</accession>
    <name>B8MHE2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_021780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484355.1">
        <property type="nucleotide sequence ID" value="XM_002484310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHE2"/>
    <dbReference type="STRING" id="441959.B8MHE2"/>
    <dbReference type="GeneID" id="8098444"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_021780"/>
    <dbReference type="eggNOG" id="ENOG502S03T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069181_0_0_1"/>
    <dbReference type="InParanoid" id="B8MHE2"/>
    <dbReference type="OMA" id="HFQYCKL"/>
    <dbReference type="OrthoDB" id="4436466at2759"/>
    <dbReference type="PhylomeDB" id="B8MHE2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED17121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="233" mass="26549" checksum="8CCF83B942A3E83E" modified="2009-03-03" version="1">MASFARYKQRIPPAILSIGKYSSVAGLFIAGAWQPWSRQCYFEPFGPENDPLFQTRFLRMYNPNNNPSVNDSCVRKVPLDKIRPELVEDALAGGSMLLERFCAGVWGGYGYALQRRIMTWSCRDESNKHMLWDKKQLLDSAYKEVLKKSSKSIIMRGGMSPSINPDKPREMDNLSEITVNIDLKQGQVEFRLKNIFFNGSENGSGALFPKPVLWLHFQYCKLLVEAGVSHCVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHM0</accession>
    <name>B8MHM0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_011130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483235.1">
        <property type="nucleotide sequence ID" value="XM_002483190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHM0"/>
    <dbReference type="GeneID" id="8109886"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_011130"/>
    <dbReference type="eggNOG" id="ENOG502S2VB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021590_1_0_1"/>
    <dbReference type="InParanoid" id="B8MHM0"/>
    <dbReference type="OMA" id="HYLSIRL"/>
    <dbReference type="OrthoDB" id="16772at2759"/>
    <dbReference type="PhylomeDB" id="B8MHM0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF13">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="68"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="486"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="123"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="534"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED16001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="565" mass="63281" checksum="84F53FD27031C5C2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHM9</accession>
    <name>B8MHM9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_011190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483244.1">
        <property type="nucleotide sequence ID" value="XM_002483199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHM9"/>
    <dbReference type="STRING" id="441959.B8MHM9"/>
    <dbReference type="GeneID" id="8109892"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_011190"/>
    <dbReference type="eggNOG" id="ENOG502RAR1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061205_0_0_1"/>
    <dbReference type="InParanoid" id="B8MHM9"/>
    <dbReference type="OMA" id="QISLHCE"/>
    <dbReference type="OrthoDB" id="5365739at2759"/>
    <dbReference type="PhylomeDB" id="B8MHM9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="354" mass="39428" checksum="BA7358BD04DD1240" modified="2009-03-03" version="1">MTPLYGADFAYKDQDLEEGTKHVSLNLPNLEHDLVCTLNFSVHIASNANIRLTRAFSSGTSHQSESDSKPSLVKRTPVSRPRVIDARSLGTRHAAPNQSNIIRAPQLRLRRGTLARGRPGAGGARKTGKSRTANAAAANKRTQRRKRDNEEDGEEVGRGNDLEAVFNEVKNASKPKPVRYTPVNYDMTALKDTWPSLPTGKTGSTGTVVERLNLLSRRYGAGYVSPIELAKRLFDGERVFFTGEEEKKTVMAEVSRLAQERADKLTQRKGDLIEPEDSSFASIKDDEKKALVGQIVRGQYEGWQKGDVRHPVLDEVQRQLYNNETYRMTGKQAEFMGKFQSLLASVQRAKRAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIF7</accession>
    <name>B8MIF7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_041190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484594.1">
        <property type="nucleotide sequence ID" value="XM_002484549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIF7"/>
    <dbReference type="GeneID" id="8109704"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_041190"/>
    <dbReference type="HOGENOM" id="CLU_2039636_0_0_1"/>
    <dbReference type="InParanoid" id="B8MIF7"/>
    <dbReference type="OrthoDB" id="4225498at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="121" mass="13257" checksum="353977EC36E785A8" modified="2009-03-03" version="1">MGKMIIVSAIELDVAIMASNAASMKAVWRKYVSKKPLTGEQGSSSCSKQKPNEPVNLPYSSRAKRSGHTRMASIDGSGSSGRKEPYENESEEELFMITELCKKGASSASADLNRPYFEFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJ55</accession>
    <name>B8MJ55_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD-binding monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_051540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485670.1">
        <property type="nucleotide sequence ID" value="XM_002485625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJ55"/>
    <dbReference type="STRING" id="441959.B8MJ55"/>
    <dbReference type="GeneID" id="8103375"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_051540"/>
    <dbReference type="eggNOG" id="ENOG502QTX9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_1_1_1"/>
    <dbReference type="InParanoid" id="B8MJ55"/>
    <dbReference type="OMA" id="AYCPSAM"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="PhylomeDB" id="B8MJ55"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051704">
        <property type="entry name" value="FAD_aromatic-hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865:SF7">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="43"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED15717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="471" mass="53139" checksum="2F9F509BB6F2BE62" modified="2009-03-03" version="1">MSALSVQRKQTVETTQLHQRKMVLDSAEYLSTSDLKNQMMPLKILICGAGITGNALAFWLSKIGHKITVIEHFPDLRATGLQLDLRGPGIQVLRKMGLEETFRRSTVKEQGMKLVDKKGRSWGYFSANRSGEGLQSLTTDFEIMRGDLCRLLYDATKVHVTYKFGMHAISIEQNTYFAEVTFSNGAQERFDIVIGADGQGSRTRKMMLDSEVTDGTLRADPFQTLGAFAGYFTVQEDIRKDEGYDATMYMTTKSRGIMTRRHDPHKYQAYLFCSTDSSERLKSSKKGDIIKEKEGFKEVFHGTGWRSEEILKALETSDDFYCERIGVIVLDHWSPGRIALVGDAAYCPSVMTGMGTSCGMTGAYVLAGEIARHYGNQSKAGTESNAITAAFNSYERKLRPLMTQVQKGLTNNPRYMESLPSSEWGVGMVYVLFWFASLLRLDVLARWVLREDTNGWKLPEYPEMVDEKRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJ67</accession>
    <name>B8MJ67_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Haloacid dehalogenase, type II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_041340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484609.1">
        <property type="nucleotide sequence ID" value="XM_002484564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJ67"/>
    <dbReference type="STRING" id="441959.B8MJ67"/>
    <dbReference type="GeneID" id="8109719"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_041340"/>
    <dbReference type="eggNOG" id="ENOG502SIF8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_3_0_1"/>
    <dbReference type="InParanoid" id="B8MJ67"/>
    <dbReference type="OMA" id="DLMGTCT"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="PhylomeDB" id="B8MJ67"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF3">
        <property type="entry name" value="HALOACID DEHALOGENASE, TYPE II (AFU_ORTHOLOGUE AFUA_2G07750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="25285" checksum="467EEB3586BC361A" modified="2009-03-03" version="1">MPNPKIKAVLFDFMGTCLDWHSGTINILPQSIPAKIGSEFALQWRQTYFDSNAARLAANLPPEDIDLTLRRTLDEMLDSGKWDEVKAGFDTHHDPNIKDKCVSAWHSMRAWPDVKPAIDQLKGLGYEVFVHANGTTRLQLDLCRSSGLSFHMLFSSELLGVYKPAAENYEKVLRFLKLRAEECVLVAAHAWTDDVEEDMEVVKRENDFFLEDMSGLVDVVGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJ89</accession>
    <name>B8MJ89_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="28">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">TSTA_041560</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
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        <source>
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        <source>
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    <sequence length="1493" mass="170669" checksum="0005F49C944645AE" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJQ5</accession>
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        <recommendedName>
            <fullName evidence="4">Dipeptidyl-peptidase V</fullName>
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        <name evidence="6" type="ORF">TSTA_051910</name>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
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        <text evidence="1">Belongs to the peptidase S9C family.</text>
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        <property type="entry name" value="DIPEPTIDYL PEPTIDASE FAMILY MEMBER 6"/>
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        <property type="entry name" value="DPP6 N-terminal domain-like"/>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED15754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="729" mass="79728" checksum="362BBC8E197FDE62" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJV4</accession>
    <name>B8MJV4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_042450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484724.1">
        <property type="nucleotide sequence ID" value="XM_002484679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJV4"/>
    <dbReference type="GeneID" id="8103338"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_042450"/>
    <dbReference type="eggNOG" id="ENOG502QQPD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031812_1_1_1"/>
    <dbReference type="InParanoid" id="B8MJV4"/>
    <dbReference type="OMA" id="LMVHPDE"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="PhylomeDB" id="B8MJV4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF8">
        <property type="entry name" value="PEPTIDASE M20 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="3">
        <location>
            <begin position="189"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED14771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="413" mass="44429" checksum="4DF9D9948065D502" modified="2009-03-03" version="1">MPSATTTKIDISQVKDVIDAAIEKSQIQLRELNRQIWSNPELAYKEHHAHDTICNFLESQGFQVTRHAFGLETAFEARSSSGDGSEAGPLINFNAEYDALPDIGHACGHNLIATSSITAFLALSAALKKFGVPGRTQLLGTPAEENGGGKAVLIENGAYKGVDISLMGHGGPSLMGDGIAGTLFNARKQIHVEFTGKNAHAGGNPWDGINALDALVAAYNNVAVLRQQILPEERIHCAFLDTPKVANVIPSFTKGYWQVRSPTLKGLNSLAARVRNCIEAAALATGCQVKLKEDSLYKDIKLNDTLCQHYQKNMGLYDRTIMKKLDKVMTASSDIGNVSYVVPTLHSAFTIRAPEGSSPHHPSFAAAAGTDAAHEEALIVGKGLALTGWDIVADVGLLKQAREQWKHEIESDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJW0</accession>
    <name>B8MJW0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_042510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484730.1">
        <property type="nucleotide sequence ID" value="XM_002484685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJW0"/>
    <dbReference type="STRING" id="441959.B8MJW0"/>
    <dbReference type="GeneID" id="8103344"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_042510"/>
    <dbReference type="eggNOG" id="ENOG502R995">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025638_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJW0"/>
    <dbReference type="OMA" id="CDHYPHP"/>
    <dbReference type="OrthoDB" id="72851at2759"/>
    <dbReference type="PhylomeDB" id="B8MJW0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06423">
        <property type="entry name" value="CESA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050321">
        <property type="entry name" value="Glycosyltr_2/OpgH_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867:SF2">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="8">
        <location>
            <begin position="246"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED14777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="512" mass="59515" checksum="FA10C8AF7EF47EE9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MK08</accession>
    <name>B8MK08_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH-ubiquinone oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_042990</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the complex I NDUFA8 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484778.1">
        <property type="nucleotide sequence ID" value="XM_002484733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MK08"/>
    <dbReference type="STRING" id="441959.B8MK08"/>
    <dbReference type="GeneID" id="8104854"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_042990"/>
    <dbReference type="eggNOG" id="KOG3458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081931_1_0_1"/>
    <dbReference type="InParanoid" id="B8MK08"/>
    <dbReference type="OMA" id="FRTHWQC"/>
    <dbReference type="OrthoDB" id="276296at2759"/>
    <dbReference type="PhylomeDB" id="B8MK08"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016680">
        <property type="entry name" value="NDUFA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017016">
        <property type="entry name" value="NDUA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED14825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="159" mass="18073" checksum="929D573B6E91399F" modified="2009-03-03" version="1">MAARQPQFSQHILVDTTPMPSDIPKVQEIGTTSAPLMSASFFIGDRCRAYNDDYMKCKAEANGRGEFECLKEGRKVTRCAASVIKDINTHCLKQFNAHWQCLENNNHHMFECRKPEVELNSCIFDKLGLKKTIPGTPENVTPVHLRPKQIYAQYPGPQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLQ2</accession>
    <name>B8MLQ2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_098810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485862.1">
        <property type="nucleotide sequence ID" value="XM_002485817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLQ2"/>
    <dbReference type="STRING" id="441959.B8MLQ2"/>
    <dbReference type="GeneID" id="8099709"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_098810"/>
    <dbReference type="eggNOG" id="ENOG502SHYH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_368051_0_0_1"/>
    <dbReference type="InParanoid" id="B8MLQ2"/>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="PhylomeDB" id="B8MLQ2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="4"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED13624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="831" mass="93418" checksum="4424A39C181C78E3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MM76</accession>
    <name>B8MM76_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_098450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485826.1">
        <property type="nucleotide sequence ID" value="XM_002485781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MM76"/>
    <dbReference type="STRING" id="441959.B8MM76"/>
    <dbReference type="GeneID" id="8099673"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_098450"/>
    <dbReference type="eggNOG" id="ENOG502RZ6Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013987_1_0_1"/>
    <dbReference type="InParanoid" id="B8MM76"/>
    <dbReference type="OMA" id="NSMIAVR"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="PhylomeDB" id="B8MM76"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF90">
        <property type="entry name" value="CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="287"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED13588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="680" mass="77615" checksum="AE731EF5D8B72922" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNB1</accession>
    <name>B8MNB1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sugar transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_102300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486238.1">
        <property type="nucleotide sequence ID" value="XM_002486193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNB1"/>
    <dbReference type="GeneID" id="8099275"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_102300"/>
    <dbReference type="eggNOG" id="KOG0253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_52_4_1"/>
    <dbReference type="InParanoid" id="B8MNB1"/>
    <dbReference type="OMA" id="FMSNFSC"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="PhylomeDB" id="B8MNB1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="68"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED14000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="522" mass="56690" checksum="E4BCD5C54566513D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNR9</accession>
    <name>B8MNR9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dihydrolipoyllysine-residue succinyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_103790</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="5"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486396.1">
        <property type="nucleotide sequence ID" value="XM_002486351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNR9"/>
    <dbReference type="FunCoup" id="B8MNR9">
        <property type="interactions" value="892"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MNR9"/>
    <dbReference type="GeneID" id="8103082"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_103790"/>
    <dbReference type="eggNOG" id="KOG0559">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_0_1_1"/>
    <dbReference type="InParanoid" id="B8MNR9"/>
    <dbReference type="OMA" id="NMPQTAV"/>
    <dbReference type="OrthoDB" id="5391403at2759"/>
    <dbReference type="PhylomeDB" id="B8MNR9"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000006">
        <property type="entry name" value="Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004309">
        <property type="entry name" value="PRK05704.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="14">
        <location>
            <begin position="72"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="141"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED14158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="459" mass="50578" checksum="45D8ACEFE3B83389" modified="2009-03-03" version="1">MASRTNLARLTRQNVLRSVHNVQKPLLSSRAYSAVALTSQRALLRPQRPVQFTRVQSPEFKLSLQQTRHYADTIVKVPEMAESITEGTLKQFSKQVGDFVERDEEIATIETDKIDVAVNAPESGTIKELLVNEEDTVTVGQPIVKLEPGSGDGAAAAEKPKDEPAPQKTEEKTETAPSKPETKEPAAPSKPEPVQEKKSEQPKPKPAESKKTEPEPSKPAQPGSREERRVKMNRMRLRIAERLKQSQNTAASLTTFNEVDMSSLMEFRKLYKDDVLKKTGVKLGFMSAFSRACVLAMKELPAVNASIEGPNGGDTIVYRDYVDISVAVATEKGLVTPVVRNAETMDMVGIEKAIADLGKKARDNKLTIEDMAGGTFTISNGGVFGSMMGTPIINLPQTAVLGLHAIKERAVVINGKVEIRPMMYLALTYDHRLLDGREAVTFLVKVKEYIEDPRRMLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNS4</accession>
    <name>B8MNS4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine protease</fullName>
            <ecNumber evidence="11">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_103830</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase C54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="11"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486401.1">
        <property type="nucleotide sequence ID" value="XM_002486356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNS4"/>
    <dbReference type="FunCoup" id="B8MNS4">
        <property type="interactions" value="299"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MNS4"/>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
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    <sequence length="454" mass="51083" checksum="51A4F5C8B48B4716" modified="2009-03-03" version="1">MNNIDLGRYKRMIQYFWDAEPKNEEGPGSKIWCLGNEYVTPEKDEFPAGSNSNINAGQTADSSRNTAPENIQIHDSKDHRPSKSDNQDPTTTDSAPTTTETAAGTESTKSLGWPKAFLDDFECRIWMTYRSGFPPIARSEDANAAQAMTLSVRLRSQLTEHHQGFTSDTGWGCMIRSGQSLLANALAISRLGRDWRRGSNSTEENRLLSLFADDPAAPFSIHKFVRHGALYCGKHPGEWFGPSATATCIQALSDEYKDAGMNVYVSSDNTYVYEDKFKAVAYNQSDRMRPTLILLGTRLGIDRITPVYRKGLEDLLKLPQALGIAGGRPSASHYFIGVQNSFFFYLDPHHTRPALPYKTGDLAYTQEEIDSCHTRRLRRIHIDDMDPSMLVGFLIRDENDWMDWKRRITSSRPENGKAIIHIVDTKNVPTPTMEREAALDEVEVLDDDEDSELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNX1</accession>
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        <name evidence="3" type="ORF">TSTA_104300</name>
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        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">ATCC 10500</strain>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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            <dbReference type="PROSITE" id="PS50213"/>
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    <evidence type="ECO:0000313" key="3">
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="528" mass="58901" checksum="52FBFDEF47FF2F48" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQF2</accession>
    <name>B8MQF2_TALSN</name>
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        <recommendedName>
            <fullName evidence="7">DUF202 domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="8" type="ORF">TSTA_058420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002487420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQF2"/>
    <dbReference type="STRING" id="441959.B8MQF2"/>
    <dbReference type="GeneID" id="8106444"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_058420"/>
    <dbReference type="eggNOG" id="ENOG502SQUP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053359_1_2_1"/>
    <dbReference type="InParanoid" id="B8MQF2"/>
    <dbReference type="OMA" id="RRFWTRN"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF1">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="7">
        <location>
            <begin position="170"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="90"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED13354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="286" mass="32068" checksum="E783CDB782C8EDA5" modified="2009-03-03" version="1">MAEVIADYEDDTISPRATRRNDGEQWNNSPDEEEHPQTQVNEEEQPCTRERESQTERTNLPRRESIESFESISSRAREATELDEIRRMSSESTSEGSLSSGEYRVTPRHSGATTTVTSTSNNTTRGSRNKNKRFQAIRRFWARNITLEVPQKGNRDYFGISFILEIHGKALERTFLAYLRTSTTFSIQGVLVAQLFRLQTSNSQASGRPPSRVNFHSVGVPLSVAYQVCAILVALLGAYRFWRQQNAIARGKVLAGGWELHGIGIMTFLAGVVLLVLAIVIIAESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRK7</accession>
    <name>B8MRK7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nucleoporin NUP49/NSP49, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_056650</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487275.1">
        <property type="nucleotide sequence ID" value="XM_002487230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRK7"/>
    <dbReference type="STRING" id="441959.B8MRK7"/>
    <dbReference type="GeneID" id="8100728"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_056650"/>
    <dbReference type="eggNOG" id="KOG0845">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027081_1_0_1"/>
    <dbReference type="InParanoid" id="B8MRK7"/>
    <dbReference type="OMA" id="KLPTHYH"/>
    <dbReference type="OrthoDB" id="2538017at2759"/>
    <dbReference type="PhylomeDB" id="B8MRK7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024882">
        <property type="entry name" value="NUP58/p45/49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437">
        <property type="entry name" value="NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437:SF2">
        <property type="entry name" value="NUCLEOPORIN P58_P45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21121">
        <property type="entry name" value="Nup49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="26"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED13164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="476" mass="49406" checksum="4A9FFF9D14ADD72D" modified="2009-03-03" version="1">MFSAKTSAPATGGLSINTSTANSLFSNTSTSTTQPATAGLFGNQQKPTGSLFGNAGSTQTTGGGLFGGQGANTSSSTQQGGMASGGLFGNTAKPATPSSGLFGNTNTQQTGTTGGGLFGNTANTQQQNTAGGSSLFGGNQGTNTQTQTKSLFGTTPSTTGTGLFGNTQNATQQQQKPTLSIFGAQNTTTQQPQAAAAQGTVVQGVRIDASNLLPTTKFESCADEIKRTIEQIDTYILTQIKTCNEVADIIPTVASQGSTVPNDVEFVSGKLETIQLALENDARDIDAVRNMVARNAAEAQVAFRAIDNLKLPLQYQSTGGGWWSVSEQQLSERQTLRSSIRNRKSTLALPDGVEGDPSTADSINGIPTNLVEYFSHRSDEMSTVLDNYRKNLKEIEDHLHGVEGSLNRQINEFLSSRNRDDGAPGGGAKNQLADLAAALGDVEAGILGVASRLGGVKEEVQELILGPPTLGMGRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8MS03</accession>
    <name>B8MS03_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-polygalacturonase</fullName>
            <ecNumber evidence="3">3.2.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_001200</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15" evidence="3"/>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487702.1">
        <property type="nucleotide sequence ID" value="XM_002487657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MS03"/>
    <dbReference type="FunCoup" id="B8MS03">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MS03"/>
    <dbReference type="GeneID" id="8098614"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_001200"/>
    <dbReference type="eggNOG" id="ENOG502QTAW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040116_0_0_1"/>
    <dbReference type="InParanoid" id="B8MS03"/>
    <dbReference type="OMA" id="GYCHGGH"/>
    <dbReference type="OrthoDB" id="1546079at2759"/>
    <dbReference type="PhylomeDB" id="B8MS03"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000002">
        <property type="entry name" value="Endopolygalacturonase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF1">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877674" description="endo-polygalacturonase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED12048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="376" mass="38128" checksum="198918A4D62FCA8C" modified="2009-03-03" version="1">MRSFITLTGLAIFCSSVALAAPAPAPIAAAKFENRASACTFSGSNGAALASKSKTSCSTIVLSNVAVPAGTTLDLTGLNEGTKVIFEGTTTFGYKEWAGPLVSVSGSDVTVEGAPGAVLNGDGARWWDGKGSNGGKKKPKFFFAHNLKSSNISNIKIENSPVQVFSINGAETLILDSITIDNSVGDSTGAHNTDAFDVGDSNGVTISNANVQNQDDCLAINSGTNIIFTGGTCSGGHGLSIGSVGGRSDNTVKTVHIENSTIKNSQNGVRIKTVSGATGSVSGVTYKDITLSGITKYGIVIEQDYENGSPTGKPTSGVPITGLAIDGVTGSVSNSATGVYILCGKGSCSNWTWEGVKITGGKKSSKCENIPSAASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MS40</accession>
    <name>B8MS40_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LRR-containing protein second PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_004860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488099.1">
        <property type="nucleotide sequence ID" value="XM_002488054.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MS40"/>
    <dbReference type="GeneID" id="8104470"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_004860"/>
    <dbReference type="eggNOG" id="ENOG502RSHR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003789_0_0_1"/>
    <dbReference type="InParanoid" id="B8MS40"/>
    <dbReference type="OMA" id="CEDAPCF"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="PhylomeDB" id="B8MS40"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057334">
        <property type="entry name" value="PH_2nd_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF41">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25353">
        <property type="entry name" value="PH_2nd_LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LRR-containing protein second PH" evidence="2">
        <location>
            <begin position="302"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1214"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1236"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1263"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1288"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1321"/>
            <end position="1334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED12445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1355" mass="149777" checksum="34535E1C3E3945FD" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSG9</accession>
    <name>B8MSG9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupin 2 conserved barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_000710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED11997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487651.1">
        <property type="nucleotide sequence ID" value="XM_002487606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSG9"/>
    <dbReference type="STRING" id="441959.B8MSG9"/>
    <dbReference type="GeneID" id="8108694"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_000710"/>
    <dbReference type="eggNOG" id="ENOG502SCP9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068080_1_0_1"/>
    <dbReference type="InParanoid" id="B8MSG9"/>
    <dbReference type="OMA" id="MSMFDAG"/>
    <dbReference type="OrthoDB" id="9976870at2759"/>
    <dbReference type="PhylomeDB" id="B8MSG9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02208">
        <property type="entry name" value="cupin_RmlC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="26958" checksum="B3C0BC2F9F6F575F" modified="2009-03-03" version="1">MATKADRVIVAFNGAIETHIFNESIDPPRAFAFEVIFYPHLWPATLLTKKPPMHFHPFQKEYIQVLAGRLCVEQSGQVRTLTPTDGEVCIKPWVNHRLYPSDDDLLRAAEDGRGDPVRFLIAGQETNKVFRLDTIFFENWYGYQDEILTEKQLDLVQVLTMFDAGGSYLSLPWWIPFGRTLSMSIGIVVGRWIGPLLGYQPYYPKWTSDWELACEKMRQSFFQRRFAERKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTD9</accession>
    <name>B8MTD9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Arabinogalactan endo-beta-1,4-galactanase</fullName>
            <ecNumber evidence="3 6">3.2.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_002500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>The enzyme specifically hydrolyzes (1-&gt;4)-beta-D-galactosidic linkages in type I arabinogalactans.</text>
            <dbReference type="EC" id="3.2.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 53 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.89" evidence="3 6"/>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487838.1">
        <property type="nucleotide sequence ID" value="XM_002487793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTD9"/>
    <dbReference type="STRING" id="441959.B8MTD9"/>
    <dbReference type="GeneID" id="8102861"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_002500"/>
    <dbReference type="eggNOG" id="ENOG502QU6R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011259_0_0_1"/>
    <dbReference type="InParanoid" id="B8MTD9"/>
    <dbReference type="OMA" id="KYIHDEW"/>
    <dbReference type="OrthoDB" id="110914at2759"/>
    <dbReference type="PhylomeDB" id="B8MTD9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031218">
        <property type="term" value="F:arabinogalactan endo-1,4-beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000077">
        <property type="entry name" value="Arabinogalactan endo-beta-1,4-galactanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011683">
        <property type="entry name" value="Glyco_hydro_53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34983">
        <property type="entry name" value="ARABINOGALACTAN ENDO-BETA-1,4-GALACTANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34983:SF1">
        <property type="entry name" value="ARABINOGALACTAN ENDO-BETA-1,4-GALACTANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07745">
        <property type="entry name" value="Glyco_hydro_53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005124044" description="Arabinogalactan endo-beta-1,4-galactanase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED12184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="353" mass="38652" checksum="41C911033429D74A" modified="2009-03-03" version="1">MKLFSLFLSLPTFASLASAALQYRGADISSLLVEEGKGISYKNVNGASAKLENILASNGVNTVRQRLWVNPSDGVYGLDYNVKLAQRMVNAGMKIYLDMHFSDTWADPSHQATPSGWSTTDIDTLTWQLYNYTMDVCNSFAEKSIPLEIVSIGNEIRAGLLWPLGSTSNYYNIARLLHSAAWGIKDSNLQTKPKILIHLDNGWSWSEQSYFYKTVLAEGPLLTSDFDLMGVSYYPFYTSSATLSSLKSTLADMASTWGKGLVVAETNWPYACPNPAYAFPSDLKSIPFSAAGQTTFLKDVANVVAETKNGLGLFYWEPAWIGNGALGSSCGDNLLVDSSTDVFRTSVQVFSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MU43</accession>
    <name>B8MU43_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Efflux pump antibiotic resistance protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_006930</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488330.1">
        <property type="nucleotide sequence ID" value="XM_002488285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MU43"/>
    <dbReference type="GeneID" id="8106826"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_006930"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="InParanoid" id="B8MU43"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="PhylomeDB" id="B8MU43"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000429">
        <property type="entry name" value="MFS drug efflux transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="47"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED12676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="532" mass="56856" checksum="5E4CEF21BCBDA02F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8MU65</accession>
    <name>B8MU65_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_109620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002488493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MU65"/>
    <dbReference type="GeneID" id="8107194"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109620"/>
    <dbReference type="eggNOG" id="ENOG502SVBM">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051551_0_0_1"/>
    <dbReference type="InParanoid" id="B8MU65"/>
    <dbReference type="OrthoDB" id="4526357at2759"/>
    <dbReference type="PhylomeDB" id="B8MU65"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="282" mass="30359" checksum="F1FA9EFDFE7A6389" modified="2009-03-03" version="1">MAQSRSEPDKRSLQTALQETTTAATTRAAEGQKIFSPIAAFLDKHRNQSASLSPHLQRALATLSDNLATMAQHHFNAYISGIIPTPSTPSPAPAPSPTPSPVPPTPPPSHPPSGLAQSSYATITKPTLAKPATAAQQTKPPIKKPISDAKQSLPDHRLFVRLPPNHVARKMDTYAIFSSLWSQLGTNSNALKEVQMIKTGFALCPTSKEALLTLEAQKEVISTYFGDCQIEQSSHWISYRYSMILVDLTILSAEITEQTGYRPISVSETTASATNANSLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-09-13" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>B8MU72</accession>
    <name>B8MU72_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_080520</name>
        <name evidence="2" type="ORF">TSTA_111050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962664">
        <property type="protein sequence ID" value="EED11441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488684.1">
        <property type="nucleotide sequence ID" value="XM_002488639.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488851.1">
        <property type="nucleotide sequence ID" value="XM_002488806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MU72"/>
    <dbReference type="GeneID" id="8108975"/>
    <dbReference type="GeneID" id="8110134"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_080520"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_111050"/>
    <dbReference type="HOGENOM" id="CLU_1422300_0_0_1"/>
    <dbReference type="InParanoid" id="B8MU72"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="191" mass="22257" checksum="952899882BF77AC3" modified="2009-03-03" version="1">MVFIEYDLNEFGSNITILQPSFNPDLTQDPVVISISRDQFVAFRIPNEYGISVIIEQHLTPKEIVVLLVNNDYALIGRVSVYNARDPSYWGKQLNGALTEQLHWRDKLADSKLFVWEPKEEIPEEFTTSFLKSWTSNWNLHATREVYEVMAKETITAMEFNKHKITRTLDSWTKCGVESKTLYRSDYLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUF7</accession>
    <name>B8MUF7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_109760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488552.1">
        <property type="nucleotide sequence ID" value="XM_002488507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUF7"/>
    <dbReference type="GeneID" id="8107208"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109760"/>
    <dbReference type="HOGENOM" id="CLU_2962483_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUF7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="59" mass="6547" checksum="6F70A78EF023BF8B" modified="2009-03-03" version="1">MLPYWHNNVSPVFDSVSSIFDSVPSIFDSISNSISSNFNYSNFSYISTKLNSVSVYGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUG2</accession>
    <name>B8MUG2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">endo-1,3(4)-beta-glucanase</fullName>
            <ecNumber evidence="4">3.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_109810</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;3)- or (1-&gt;4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.</text>
            <dbReference type="EC" id="3.2.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.6" evidence="4"/>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488557.1">
        <property type="nucleotide sequence ID" value="XM_002488512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUG2"/>
    <dbReference type="STRING" id="441959.B8MUG2"/>
    <dbReference type="GeneID" id="8107213"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109810"/>
    <dbReference type="eggNOG" id="ENOG502QUM3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016972_1_1_1"/>
    <dbReference type="InParanoid" id="B8MUG2"/>
    <dbReference type="OMA" id="NTMTLHT"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="PhylomeDB" id="B8MUG2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000114">
        <property type="entry name" value="Probable endo-1,3(4)-beta-glucanase NFIA_089530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002878018" description="endo-1,3(4)-beta-glucanase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="21"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED11801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="315" mass="34662" checksum="B7EB8342A074DECF" modified="2009-03-03" version="1">MFFLTIIASIFLFFHLVKASYHLKKSFTKNGAFFENFEFFTGADPTKGYVNYMGREAATEAGLAKTLANGTVYLGVDSHTIMKSSGRPSVRLTSNDSFKYGLLMLDLIHMPDSVCGTWPAFWLLGSDWPTNGEIDIIEGVNIDSNNTMTLHTSSNCQMTQSDFSGTMVTSNCNVAAAGQPANAGCSIISDSNVSYGTKFNQQGGGIYAMEWTDSEINIWLFTRNGNLFPDMSCDNMDPTFWGKPTAQFKGDCNFNDYLGPQAVVFDTTFCGDWAGSVWKASSCAELASSCEQFVAENPSAFANTYWQIKTLNLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUT8</accession>
    <name>B8MUT8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_110380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488614.1">
        <property type="nucleotide sequence ID" value="XM_002488569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUT8"/>
    <dbReference type="STRING" id="441959.B8MUT8"/>
    <dbReference type="GeneID" id="8107270"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_110380"/>
    <dbReference type="eggNOG" id="ENOG502QXCA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_883330_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUT8"/>
    <dbReference type="OrthoDB" id="4509126at2759"/>
    <dbReference type="PhylomeDB" id="B8MUT8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="315" mass="35508" checksum="CDC86C46DBC72C1D" modified="2009-03-03" version="1">MTRNQSIYGLVLLALGFENKYKPLEIVTYNPTVPEGGPQTPENSARNEAIPTAPGRRQNHQAETLRAPVVEFPSLDDGKRIIYQTVASLISSLKKVITQQTNIIKLARAEIHEIKTDNPQNQLINDQHNPMTPERTELRPNQYCTAKAADNNGNNKDNFTRSLPTDAANKHIKIALSITEPTKEVQVVGISTTKTGYVIRFRDAQSAETARNNTEWLEELGNETKLEKKKGIEKIMEENDLAEKGFEIDDIAWLKKKDRPLGKSASMGIWLNTPEAAELIISNGLLVRQRYIGSVELYKVELKRYHHCQKFGHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8MVG6</accession>
    <name>B8MVG6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450 monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_007650</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962663">
        <property type="protein sequence ID" value="EED11475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488791.1">
        <property type="nucleotide sequence ID" value="XM_002488746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MVG6"/>
    <dbReference type="STRING" id="441959.B8MVG6"/>
    <dbReference type="GeneID" id="8103294"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_007650"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020492_2_0_1"/>
    <dbReference type="InParanoid" id="B8MVG6"/>
    <dbReference type="OMA" id="IYNCNSI"/>
    <dbReference type="OrthoDB" id="10029320at2759"/>
    <dbReference type="PhylomeDB" id="B8MVG6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11051">
        <property type="entry name" value="CYP59-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF50">
        <property type="entry name" value="BIFUNCTIONAL ALBAFLAVENONE MONOOXYGENASE_TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="524"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED11475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="588" mass="66683" checksum="EDDCC153B96377FE" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B8MVI9</accession>
    <name>B8MVI9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ankyrin repeat-containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_080300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962664">
        <property type="protein sequence ID" value="EED11416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488826.1">
        <property type="nucleotide sequence ID" value="XM_002488781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MVI9"/>
    <dbReference type="STRING" id="441959.B8MVI9"/>
    <dbReference type="GeneID" id="8108953"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_080300"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_307209_0_0_1"/>
    <dbReference type="InParanoid" id="B8MVI9"/>
    <dbReference type="OrthoDB" id="4207519at2759"/>
    <dbReference type="PhylomeDB" id="B8MVI9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="M-PHASE PHOSPHOPROTEIN 8"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="16"/>
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    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="7">
        <location>
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            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
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    <feature type="repeat" description="ANK" evidence="6">
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    <feature type="repeat" description="ANK" evidence="6">
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    <feature type="repeat" description="ANK" evidence="6">
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    <feature type="repeat" description="ANK" evidence="6">
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="963" mass="107499" checksum="CE48D21DA84B57F9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8LSX0</accession>
    <name>B8LSX0_TALSN</name>
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        <recommendedName>
            <fullName evidence="11">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="11">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
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        <name evidence="15" type="ORF">TSTA_064350</name>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
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        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6 11 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="188"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="418"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="32"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
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            <end position="521"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="725"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="486"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="506"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="732"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="770"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED22966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="802" mass="87475" checksum="D1E12BD59942E4DF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTT9</accession>
    <name>B8LTT9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="2 12">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_070860</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <text evidence="9 12">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
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            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NrdE_NrdA_C"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
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        <property type="entry name" value="Rrm1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="815"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
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            <end position="850"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047754"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED23681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="873" mass="97975" checksum="94330C1F0AFE9EBD" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-09-13" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>B8LU47</accession>
    <name>B8LU47_TALSN</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_060170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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        </lineage>
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            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="EED22519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="160" mass="18133" checksum="69C8E658CF0BC102" modified="2009-03-03" version="1">MSWLVSILEWCFGGDDDLTPLTNNEIEPVNARDPEKGVRIIDVDSNTIFTVSISGECKRITFGELQQKNIYLEALIRYFQERPPEAKRPSEDSKITEVNYKEGTLSSASFISKDNMANPPSWNWRAVMENPSGFNALHWYYYGGDLGDSPHAFLCTSESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
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    <name>B8LU98_TALSN</name>
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        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LU98"/>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_060620"/>
    <dbReference type="eggNOG" id="ENOG502S2ZX">
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    <dbReference type="HOGENOM" id="CLU_330985_0_0_1"/>
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    <dbReference type="OMA" id="NHENEQH"/>
    <dbReference type="OrthoDB" id="7477068at2759"/>
    <dbReference type="PhylomeDB" id="B8LU98"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
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    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
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        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="391"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="780"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED22570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="866" mass="99120" checksum="48AD6232C2C804FA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUM1</accession>
    <name>B8LUM1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S ribosomal protein S2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_072680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341265.1">
        <property type="nucleotide sequence ID" value="XM_002341224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUM1"/>
    <dbReference type="FunCoup" id="B8LUM1">
        <property type="interactions" value="717"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LUM1"/>
    <dbReference type="GeneID" id="8104396"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_072680"/>
    <dbReference type="eggNOG" id="KOG0832">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040318_4_2_1"/>
    <dbReference type="InParanoid" id="B8LUM1"/>
    <dbReference type="OMA" id="PYIFMEK"/>
    <dbReference type="OrthoDB" id="2320368at2759"/>
    <dbReference type="PhylomeDB" id="B8LUM1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000061">
        <property type="entry name" value="40S ribosomal protein S2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_uS2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_uS2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S2 PROKARYOTIC AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED23878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="344" mass="37893" checksum="DF235F6E71C9A978" modified="2009-03-03" version="1">MIIRQLGLRQGRNVSLIRQGLVRFSSTETTTTTTTITAEQTLPLSGNGESSSTIVQSVQASRTSTSVSPALKSRKAFLQAARQRQKLKSIGTTISQTYDPNTLLKNPPKPAEVTLELLLASQSHLGHTTSRWNPQNSRYIFGIREGVHIISLDVTAAYLRRAAKVVEEVARRGGLILFAGTRPGQKECVVRAAEMARGYHVFERWIPGSLTNGQQILGNCEIKVVNALDEELPDYKQYLTERPVLKPDLVICLNPIENEVLLHECGLNNIPTIGIIDTDADPTRVTYPIPANDDSLRCVQLIAGALGRAGEEGQRLRLLEAQQGRFTYTPVGERDVKRSSEGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUR1</accession>
    <name>B8LUR1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetylglucosaminyl transferase component Gpi1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_073080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341305.1">
        <property type="nucleotide sequence ID" value="XM_002341264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUR1"/>
    <dbReference type="FunCoup" id="B8LUR1">
        <property type="interactions" value="92"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LUR1"/>
    <dbReference type="GeneID" id="8110231"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_073080"/>
    <dbReference type="eggNOG" id="KOG1183">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007914_2_0_1"/>
    <dbReference type="InParanoid" id="B8LUR1"/>
    <dbReference type="OMA" id="HPTRMQY"/>
    <dbReference type="OrthoDB" id="70250at2759"/>
    <dbReference type="PhylomeDB" id="B8LUR1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="552"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="597"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED23918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="805" mass="91478" checksum="09B95C6A37FAC5A3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUW7</accession>
    <name>B8LUW7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_060800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002339975.1">
        <property type="nucleotide sequence ID" value="XM_002339934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUW7"/>
    <dbReference type="GeneID" id="8108515"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_060800"/>
    <dbReference type="eggNOG" id="ENOG502RS53">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_829433_0_0_1"/>
    <dbReference type="InParanoid" id="B8LUW7"/>
    <dbReference type="OrthoDB" id="4216327at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002874511" description="RNase H type-1 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="207"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED22588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="335" mass="37780" checksum="798EA53D34DD5C98" modified="2009-03-03" version="1">MKLSIFARLGALSPLILTAANAADCTAPNQQWYDLSAVQMMWSIRAWVCPNAWWQSITAGPDGAWCHVNGDLAGSYWGSWTISGMQSEQECWDVLEQIIDQCMWYDYKLTSYNGGTWKWGNTYAGGWFWADNSKPCVHAVQARGSEETETETETIGYGAPTNFTLANGTVMKINRQVWLNLSEDGSPKLVREETYEGEHNGVRKKPVIFSDSQAALRTLMNPRMVSGQTYFRDCVELLKKCMDKDIDVTLRWIPGHEGVPGNEAADRAAKRAALIGARRQVVPGDIYGWIMLAAAAKRRIRQSTKDAWERSWDRQKAGKPIKKLINKPSKRTLQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUX0</accession>
    <name>B8LUX0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_060830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002339978.1">
        <property type="nucleotide sequence ID" value="XM_002339937.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LUX0"/>
    <dbReference type="GeneID" id="8108612"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_060830"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002055_0_1_1"/>
    <dbReference type="InParanoid" id="B8LUX0"/>
    <dbReference type="OMA" id="WELENTW"/>
    <dbReference type="OrthoDB" id="3562262at2759"/>
    <dbReference type="PhylomeDB" id="B8LUX0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="807"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1065"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1114"/>
            <end position="1127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED22591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1712" mass="194602" checksum="72BFC0C3C41CB85B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUX6</accession>
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        </recommendedName>
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        <name evidence="9" type="ORF">TSTA_060880</name>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="8104734"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_060880"/>
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    </dbReference>
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    <dbReference type="PhylomeDB" id="B8LUX6"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:DNA-templated transcription"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        </location>
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        <location>
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        </location>
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    </feature>
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            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="758" mass="84448" checksum="44933CB635E831AE" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8LV71</accession>
    <name>B8LV71_TALSN</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">TSTA_065740</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Trichocomaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="441959.B8LV71"/>
    <dbReference type="GeneID" id="8105992"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_065740"/>
    <dbReference type="eggNOG" id="ENOG502S0DI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028621_0_0_1"/>
    <dbReference type="InParanoid" id="B8LV71"/>
    <dbReference type="OMA" id="KVVFRWK"/>
    <dbReference type="OrthoDB" id="3357341at2759"/>
    <dbReference type="PhylomeDB" id="B8LV71"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="252"/>
            <end position="508"/>
        </location>
    </feature>
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        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
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        </location>
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            <end position="384"/>
        </location>
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            <end position="406"/>
        </location>
    </feature>
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        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED23121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="508" mass="57484" checksum="ED6B5F51FEDA01B7" modified="2009-03-03" version="1">MLDENLPTFYLSNDKKKKSNNVLFTQHGDEPEPAYTLRRLDPTDPASRNRYAVALYDPYIPDVLYGEVLIIPEWTQPTLSAEAIRQNGGAPPPPEPIMPSQFTVHLYNPDQEVIVRHKPKTWNSQPSWEFEMPQQSFKQPSNSTLDQIQSGPAASEVTPKLKFVWRKDGSLSKDFACYLSGKTTTPDGRKKNKEPDITVSIFKGLKEITLYEPNLYRVEMEDFKGLEVVLMLGAVVIRDVFFAPLKDAFNVVSSPTSSRTNSAAAAVPTVPNNTNTKKPAAAANVNSNPPRPTTALPLRDTRPPPNHQSLDPRAKWEIDAENARIKQQEEAARKERRRKAEEEERRTRKLLEAEQRAQRKKQAEIDKETERLKKMYGKEDEKSRQQRPNHSQRHSASPAIIVSSSSHTNPSHQARYSHYMPTPPQQPPRPGPYMQPSAGYHSTVNLRPPQPHPRPQSSMSYLGVPNAHPTASTPEIPRLKERRSIFNLFKPSDGGDSNRLSKKRSSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVD5</accession>
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        <submittedName>
            <fullName evidence="9">DUF6 domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_073430</name>
    </gene>
    <organism evidence="9 10">
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        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <end position="177"/>
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        <location>
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            <end position="213"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="266"/>
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    </feature>
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        <location>
            <begin position="308"/>
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    </feature>
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    </feature>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="437"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="461"/>
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    </feature>
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        <location>
            <begin position="122"/>
            <end position="262"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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    </feature>
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        <location>
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            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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            <dbReference type="EMBL" id="EED23954.1"/>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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        <subcellularLocation>
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            <end position="89"/>
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            <end position="904"/>
        </location>
    </feature>
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            <end position="1572"/>
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        <location>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF16507"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF23096"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
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    </evidence>
    <sequence length="1966" mass="223053" checksum="DB93DD550F3E1716" modified="2009-03-03" version="1"> </sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
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        <subcellularLocation>
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    <dbReference type="PhylomeDB" id="B8LWL7"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF139">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="57"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED24414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="540" mass="59367" checksum="2507E31DA0C968E7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>B8LX15</accession>
    <name>B8LX15_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10 11">Catalase-peroxidase</fullName>
            <shortName evidence="10">CP</shortName>
            <ecNumber evidence="10 11">1.11.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Peroxidase/catalase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">katG</name>
        <name evidence="14" type="ORF">TSTA_061530</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 10 11">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10 11">
            <text>H2O2 + AH2 = A + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30275"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="10">Binds 1 heme b (iron(II)-protoporphyrin IX) group per monomer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the peroxidase family. Peroxidase/catalase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.21" evidence="10 11"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340052.1">
        <property type="nucleotide sequence ID" value="XM_002340011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LX15"/>
    <dbReference type="STRING" id="441959.B8LX15"/>
    <dbReference type="GeneID" id="8106623"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_061530"/>
    <dbReference type="eggNOG" id="ENOG502QTDY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025424_2_0_1"/>
    <dbReference type="InParanoid" id="B8LX15"/>
    <dbReference type="OMA" id="GPETTWL"/>
    <dbReference type="OrthoDB" id="407695at2759"/>
    <dbReference type="PhylomeDB" id="B8LX15"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00649">
        <property type="entry name" value="catalase_peroxidase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08200">
        <property type="entry name" value="catalase_peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000002">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000004">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000002">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01961">
        <property type="entry name" value="Catal_peroxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000763">
        <property type="entry name" value="Catalase_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00198">
        <property type="entry name" value="cat_per_HPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011635">
        <property type="entry name" value="PRK15061.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555:SF0">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555">
        <property type="entry name" value="HYDROPEROXIDASE I, BIFUNCTIONAL CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00460">
        <property type="entry name" value="BPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10 11" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="5 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="3 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 10 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="13">
        <location>
            <begin position="131"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="290"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="cross-link" description="Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-97)" evidence="10">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED22665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="768" mass="84442" checksum="C780A72DB8FCD0C7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8LY20</accession>
    <name>B8LY20_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Ile)-lysidine synthetase</fullName>
            <ecNumber evidence="1">6.3.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_067070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(34) in tRNA(Ile2) + L-lysine + ATP = lysidine(34) in tRNA(Ile2) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="1"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340652.1">
        <property type="nucleotide sequence ID" value="XM_002340611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LY20"/>
    <dbReference type="STRING" id="441959.B8LY20"/>
    <dbReference type="GeneID" id="8102356"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_067070"/>
    <dbReference type="eggNOG" id="ENOG502RZPD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015599_1_0_1"/>
    <dbReference type="InParanoid" id="B8LY20"/>
    <dbReference type="OMA" id="ARIPECH"/>
    <dbReference type="OrthoDB" id="434144at2759"/>
    <dbReference type="PhylomeDB" id="B8LY20"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032267">
        <property type="term" value="F:tRNA(Ile)-lysidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="TRNA(ILE)-LYSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033:SF1">
        <property type="entry name" value="TRNA(ILE)-LYSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="8">
        <location>
            <begin position="45"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED23265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="630" mass="71851" checksum="BF914C062926F617" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8LY32</accession>
    <name>B8LY32_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Porphobilinogen deaminase</fullName>
            <ecNumber evidence="5">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Hydroxymethylbilane synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_067180</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="5"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340664.1">
        <property type="nucleotide sequence ID" value="XM_002340623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LY32"/>
    <dbReference type="FunCoup" id="B8LY32">
        <property type="interactions" value="648"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LY32"/>
    <dbReference type="GeneID" id="8108526"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_067180"/>
    <dbReference type="eggNOG" id="KOG2892">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019704_0_2_1"/>
    <dbReference type="InParanoid" id="B8LY32"/>
    <dbReference type="OMA" id="LWQANHI"/>
    <dbReference type="OrthoDB" id="564646at2759"/>
    <dbReference type="PhylomeDB" id="B8LY32"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000005">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000086">
        <property type="entry name" value="Probable porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="entry name" value="Porphobilinogen deaminase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobilinogen deaminase N-terminal" evidence="13">
        <location>
            <begin position="14"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobilinogen deaminase C-terminal" evidence="14">
        <location>
            <begin position="240"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED23277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="335" mass="36400" checksum="2AC610B3A71167A8" modified="2009-03-03" version="1">MSTAPLASERKTFNIGTRKSKLALAQTYMVVDALKKEYPQYEFNIKSKDTAGDRDKITAFKDMQTKNLWTEELEELLIGGQLDFIVHSLKDVPTLLPPTCALGGVLPREDPRDVLIVKPGLPYTSLAEIPAGSVVGTSSIRRTAQLAMKFPHLKVQSLRGNIDTRLAKLDGEDSPYTCIILAAAGLLRTGMGHRITQYLDSRSGSLLYAVGQGAIGIEVRSDDGLVLEMLNKVGDQKTFKEVLAERSLLRTIEGGCSAPLGVESEWINEVEGTTKLHVRSIIVSVDGKRHSTAELEKVIESAAAAETFGLELAQELIANGAGPILEEIKQNKVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYR4</accession>
    <name>B8LYR4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSTA_068470</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340809.1">
        <property type="nucleotide sequence ID" value="XM_002340768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYR4"/>
    <dbReference type="FunCoup" id="B8LYR4">
        <property type="interactions" value="959"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LYR4"/>
    <dbReference type="GeneID" id="8108596"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_068470"/>
    <dbReference type="eggNOG" id="KOG0347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_13_0_1"/>
    <dbReference type="InParanoid" id="B8LYR4"/>
    <dbReference type="OMA" id="QMIQKAR"/>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="PhylomeDB" id="B8LYR4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
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        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
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            <begin position="213"/>
            <end position="426"/>
        </location>
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        <location>
            <begin position="478"/>
            <end position="626"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
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        <location>
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            <end position="164"/>
        </location>
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        <location>
            <begin position="369"/>
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        <location>
            <begin position="680"/>
            <end position="705"/>
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        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
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        <location>
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        </location>
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            <end position="150"/>
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            <end position="393"/>
        </location>
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        <source>
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        </source>
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            <dbReference type="ARBA" id="ARBA00047984"/>
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        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS51194"/>
        </source>
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            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="EED23422.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="765" mass="84227" checksum="08ADF2205EF9E6AC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZR1</accession>
    <name>B8LZR1_TALSN</name>
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        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">TSTA_080760</name>
    </gene>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED20843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED20843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="43166" checksum="D5048A1881F03FC4" modified="2009-03-03" version="1">MVVEIRDITQAYTQAKTKLQRIIIVNLPKEMRGKYPLDSLLLVEGALYGIPKASVHWFGTYHEYYKVKIDMETSMYDPCLLMIKLGAKSFGLVDMQTNNILIIAIEKFARDEERALQEVRFKAKPKTQLSQDTPLEFNGIEPVGTIDRAQKYIEQQARGAYLASICQPEASYDLAITAQLQEKDRFKDDYLALNKRLIWQAENPERGLRFIPLDLTKAKIMIFTDESFTNNQDLTSQIGFLIAMVNEDFSEEGHFIATGNIIHWTSSKCKRVTRSVLALEIYGLTTGFDYGITLVSTIKMIMDRLNLPTIPVVVYTNSYSLYECLVKLGTTKEKRLMIDLMVLRQSYEKREIDEIRWIHGDNNPADAFTKANLNGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0J1</accession>
    <name>B8M0J1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_085190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002478206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0J1"/>
    <dbReference type="STRING" id="441959.B8M0J1"/>
    <dbReference type="GeneID" id="8106125"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_085190"/>
    <dbReference type="eggNOG" id="KOG0710">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_769817_0_0_1"/>
    <dbReference type="InParanoid" id="B8M0J1"/>
    <dbReference type="OMA" id="YHGPWGW"/>
    <dbReference type="OrthoDB" id="5511210at2759"/>
    <dbReference type="PhylomeDB" id="B8M0J1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="144"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="106"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED21288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="360" mass="40199" checksum="00DF4AD2E26B1529" modified="2009-03-03" version="1">MSLFCDPQHPCWGAPVSFQPQFPPNIGNHPGHNNGEHHGPSRGGPHHRGHRGHPIFGGWGHPHHGHYRLQRAPGLGDQADGLFGTSRGGRGDMFGHRGGHRPYYGNPRGQHRGRGRATHDVLPDPHHGGSTFEFPSPGRDSNESERVDFEPPADVFDTSTEYIIHVSLPGANKSDINVEYDAEKSIVRIEGVVYRPEITEELHAAMIWNGRRREVGAFERCFEIMPFSFGAADFDGQKITAKMVNGILIVRLPKSPKEVQGEKQNKKVVINIDDDLYDADFVEEKGKAVEHEQEDIETTSKNEQYASVVEVEDEMDSMHLSSETETGDLLEEIDNTIYTPSQMSDEDIEEAAEYVRVDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1B4</accession>
    <name>B8M1B4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isochorismatase domain-containing protein 2, mitochondrial, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_090490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478773.1">
        <property type="nucleotide sequence ID" value="XM_002478728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1B4"/>
    <dbReference type="STRING" id="441959.B8M1B4"/>
    <dbReference type="GeneID" id="8101540"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_090490"/>
    <dbReference type="eggNOG" id="KOG4044">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066901_0_1_1"/>
    <dbReference type="InParanoid" id="B8M1B4"/>
    <dbReference type="OMA" id="DFCAVET"/>
    <dbReference type="OrthoDB" id="269496at2759"/>
    <dbReference type="PhylomeDB" id="B8M1B4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050993">
        <property type="entry name" value="Isochorismatase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119:SF3">
        <property type="entry name" value="ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="2">
        <location>
            <begin position="19"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED21810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="183" mass="20574" checksum="A75434228C15F429" modified="2009-03-03" version="1">MKLFRDKKLIQHNFSEKSICTLAEIIKPFGIPAIITTQCVPRYGPCVPSIKKHLGDNTPEFDKSKFSMMTKEVFDFLKREKRDHVVVVGVEAHICVSQTVFELQKHGYKVVVLADAVSSSSFQERNLALRRMLASGISVNSLEGWTFELLGSSDHPLYDKSESSQCGLLVQSDFCAVETDEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1L9</accession>
    <name>B8M1L9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Integral membrane protein (Ptm1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_093520</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LU7TM family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479069.1">
        <property type="nucleotide sequence ID" value="XM_002479024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1L9"/>
    <dbReference type="FunCoup" id="B8M1L9">
        <property type="interactions" value="748"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M1L9"/>
    <dbReference type="GeneID" id="8102596"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_093520"/>
    <dbReference type="eggNOG" id="KOG2568">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024065_1_0_1"/>
    <dbReference type="InParanoid" id="B8M1L9"/>
    <dbReference type="OMA" id="TWGFYDF"/>
    <dbReference type="OrthoDB" id="19932at2759"/>
    <dbReference type="PhylomeDB" id="B8M1L9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053938">
        <property type="entry name" value="PTM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21902">
        <property type="entry name" value="PTM1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002874695" evidence="9">
        <location>
            <begin position="21"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="PTM1-like N-terminal" evidence="11">
        <location>
            <begin position="31"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="10">
        <location>
            <begin position="185"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="474"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="508"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED22106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="540" mass="60632" checksum="9B6A126B662D4DD0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2Z1</accession>
    <name>B8M2Z1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipin Smp2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_094920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lipin family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479209.1">
        <property type="nucleotide sequence ID" value="XM_002479164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2Z1"/>
    <dbReference type="FunCoup" id="B8M2Z1">
        <property type="interactions" value="460"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M2Z1"/>
    <dbReference type="GeneID" id="8103822"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_094920"/>
    <dbReference type="eggNOG" id="KOG2116">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002546_3_0_1"/>
    <dbReference type="InParanoid" id="B8M2Z1"/>
    <dbReference type="OMA" id="QDYSMKL"/>
    <dbReference type="OrthoDB" id="4567at2759"/>
    <dbReference type="PhylomeDB" id="B8M2Z1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000063">
        <property type="entry name" value="Nuclear elongation and deformation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057124">
        <property type="entry name" value="Ned1-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24565">
        <property type="entry name" value="Ned1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="4">
        <location>
            <begin position="442"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="153"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="332"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="648"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="653"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="671"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="710"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED22246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="731" mass="80119" checksum="067CF4F1E59773AC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8M309</accession>
    <name>B8M309_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_092270</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478948.1">
        <property type="nucleotide sequence ID" value="XM_002478903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M309"/>
    <dbReference type="STRING" id="441959.B8M309"/>
    <dbReference type="GeneID" id="8099409"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_092270"/>
    <dbReference type="eggNOG" id="KOG1397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008721_4_0_1"/>
    <dbReference type="InParanoid" id="B8M309"/>
    <dbReference type="OMA" id="WNPFRHV"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="PhylomeDB" id="B8M309"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000011">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF20">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="153"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="376"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED21985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="526" mass="56914" checksum="6A59B752B01EEC13" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3N9</accession>
    <name>B8M3N9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calcineurin binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_096600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RCAN family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479374.1">
        <property type="nucleotide sequence ID" value="XM_002479329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3N9"/>
    <dbReference type="STRING" id="441959.B8M3N9"/>
    <dbReference type="GeneID" id="8103503"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_096600"/>
    <dbReference type="eggNOG" id="KOG4019">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050705_0_0_1"/>
    <dbReference type="InParanoid" id="B8M3N9"/>
    <dbReference type="OMA" id="RIVCSFH"/>
    <dbReference type="OrthoDB" id="17212at2759"/>
    <dbReference type="PhylomeDB" id="B8M3N9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008597">
        <property type="term" value="F:calcium-dependent protein serine/threonine phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000503">
        <property type="entry name" value="Calcineurin binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006931">
        <property type="entry name" value="Calcipressin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300">
        <property type="entry name" value="CALCIPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300:SF14">
        <property type="entry name" value="PROTEIN SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04847">
        <property type="entry name" value="Calcipressin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="207"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED22411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="324" mass="35070" checksum="A19914F73C5C36EE" modified="2009-03-03" version="1">MTVAIASTSLQQSHARIRKFSERNNKMASVEASSNQSSPRPKPALTLDLSNLPPLSRPSPPSNTLIITELHNLLVFQPASLTSIREKIISIAPLNSFSPLPSFRRIVCSFLSVDDAVKVRQGLESSKTVIDECGLRARIYFGEPTPIIENTEEAKRKKLLEAPHSQKMFFISPPPSPPHGWVVRNEEPPNKEVHASDLADALAKLGTQQQQQQQQQQTTSDSDPLSPVSVVSSAENNQRETTPGVTRSNGSWPSSAGGAGGRSRSSTLIYHPNDHGGSPNLPAVMVEDTSIGEDDDAEDDDLMLMGGGGKILAHTARPPVELMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3S4</accession>
    <name>B8M3S4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8035 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_038720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481101.1">
        <property type="nucleotide sequence ID" value="XM_002481056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3S4"/>
    <dbReference type="STRING" id="441959.B8M3S4"/>
    <dbReference type="GeneID" id="8107914"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_038720"/>
    <dbReference type="eggNOG" id="ENOG502SSBZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053162_0_0_1"/>
    <dbReference type="InParanoid" id="B8M3S4"/>
    <dbReference type="OMA" id="YREVEVH"/>
    <dbReference type="OrthoDB" id="5428245at2759"/>
    <dbReference type="PhylomeDB" id="B8M3S4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26118">
        <property type="entry name" value="DUF8035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8035" evidence="2">
        <location>
            <begin position="215"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED20667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="485" mass="57335" checksum="E5A9F8A2DD56A1D8" modified="2009-03-03" version="1">MPTYDEIRSATESLDSGGGRWDTERFTRERDERIYRGPAPAPLRERSRSRPPPPPPEFDRRRPGGFDDRFERRVVEEDRYGLPGRRRERFVEEDDYYAARGSGPLVHRREPSPSFRPPRLVRRQSSLDTFDRLPARRIERVPPPPVRGFRGGPPRRSSPPRFVGRDELYEEIDIAEPDEYGDEEFRHFREREMRRPVREEIVKERIIEKEKPYPRKGKTKMPKRLVHPRAVQQLGYPYIEEDRVIIIQKALSKELIDEIVTLSKEIRRRSETVYRTYRSPSPPPVRERELVERVVIASPSPRRSERLYVERSPSPVRAERLIVEHSPARTERLVVEHSPARTEHLIVERSPSPLRYRSPSRVRTSRYLERPDIIETRPRSVSVNLPQRSSEPVIVERRDDSAGQVVLVERPRRTELDVSEEIRMLEDERRMLQIERRPEHVGSVDIIRDKVIRRSDGETDEIIEVNKNRRAPDSRLIRAMMATLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3W2</accession>
    <name>B8M3W2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_039090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481139.1">
        <property type="nucleotide sequence ID" value="XM_002481094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3W2"/>
    <dbReference type="STRING" id="441959.B8M3W2"/>
    <dbReference type="GeneID" id="8109247"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_039090"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009184_2_0_1"/>
    <dbReference type="InParanoid" id="B8M3W2"/>
    <dbReference type="OMA" id="YGYCSGD"/>
    <dbReference type="OrthoDB" id="4225813at2759"/>
    <dbReference type="PhylomeDB" id="B8M3W2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="150"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED20705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="643" mass="72144" checksum="652A3BBF0718EA03" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4C0</accession>
    <name>B8M4C0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspergillopepsin-2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_024390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479549.1">
        <property type="nucleotide sequence ID" value="XM_002479504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4C0"/>
    <dbReference type="STRING" id="441959.B8M4C0"/>
    <dbReference type="GeneID" id="8097970"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_024390"/>
    <dbReference type="eggNOG" id="ENOG502RJF6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066466_0_1_1"/>
    <dbReference type="InParanoid" id="B8M4C0"/>
    <dbReference type="OMA" id="EWYPEFS"/>
    <dbReference type="OrthoDB" id="2862635at2759"/>
    <dbReference type="PhylomeDB" id="B8M4C0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00977">
        <property type="entry name" value="SCYTLDPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002874707" evidence="2">
        <location>
            <begin position="21"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="282" mass="29333" checksum="1452BFD886B2261C" modified="2009-03-03" version="1">MKASTLALSQILLLAASVAAAVTRGHGLAARVAARGEIARLTHPKVPAVDVNEDEAANRTNVDYSSNWSGGVLTAPPSGTKFTSVTAQFTVPKPSLPSGATQDSYASAWVGIDGDTYTTAILQTGVDFGISTSGQISYDAWYEWYPDYAYDFSGIDISTGDTIRLTVTSTNNDAGVAVIENLSNGQSVTQSLKAPSSTATLGGQNAEWIVEDFDSNGRQVPFADFGTVRFIDAAAGTEDGGTVGTSEADLLDISQNGKVLTSASAPSDTEIVVEWTVTSMGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4J4</accession>
    <name>B8M4J4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH64 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_025110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479623.1">
        <property type="nucleotide sequence ID" value="XM_002479578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4J4"/>
    <dbReference type="GeneID" id="8106728"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_025110"/>
    <dbReference type="eggNOG" id="ENOG502SJJ1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032886_0_0_1"/>
    <dbReference type="InParanoid" id="B8M4J4"/>
    <dbReference type="OMA" id="RIIHANM"/>
    <dbReference type="OrthoDB" id="5290283at2759"/>
    <dbReference type="PhylomeDB" id="B8M4J4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09220">
        <property type="entry name" value="GH64-GluB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.50">
        <property type="entry name" value="Beta-1,3-glucanase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032477">
        <property type="entry name" value="Glyco_hydro_64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037398">
        <property type="entry name" value="Glyco_hydro_64_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042517">
        <property type="entry name" value="Glyco_hydro_64_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38165">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38165:SF1">
        <property type="entry name" value="GLUCANASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16483">
        <property type="entry name" value="Glyco_hydro_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52006">
        <property type="entry name" value="GH64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="GH64" evidence="3">
        <location>
            <begin position="79"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS52006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED19189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="463" mass="48546" checksum="B9E80DE5929395C6" modified="2009-03-03" version="1">MKQVILSRTLPVIYLIMLGLSKYAVVVATVLSIIAPTVARPTELHPGDASDLIINAQDTINGTISASASKTQGIHATNGTALKFTITNNIAGNVNCYINGQDPNKNNAPVMLTPNFLWYYPTASTNADGTPAPVTESVAIPLNAQGLTTTIMIPSYVVSARVWFAVGELQFFTVAGDNGSFSVVQPSQSNPADPSAGINWGFIEFSYTADGGIYANISYVDFVGLPLGMSLTDTSNGVQTALGLKADAVTNVCNDLAAQAVKDSLPWDALCQSINGTVMRVLSPNDYMAANKSSGFETYFDDYVNEVWDNYTSKPLVIDTQNNAGNVSCTVSGDTLQCPDDGINYSKPSTADIFGCNSGPFVTNPTDSSVHQATVPRLCAAFNRGTLLLPGGDVQPSLGADSYYTSGPSNFYSAIVHKYEVDGKGYAFAYDDVNPSGDGENASGTVSSANPSVLGVTVGGPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4Q1</accession>
    <name>B8M4Q1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_025630</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479680.1">
        <property type="nucleotide sequence ID" value="XM_002479635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4Q1"/>
    <dbReference type="GeneID" id="8107975"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_025630"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1094892_0_0_1"/>
    <dbReference type="InParanoid" id="B8M4Q1"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="PhylomeDB" id="B8M4Q1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877538" evidence="9">
        <location>
            <begin position="21"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED19246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="254" mass="27781" checksum="EBE2ECD05668755A" modified="2009-03-03" version="1">MVRILMLFIQSQFLLDEAIADAFMQKTANNSSHSSVVLMRNTTSSHEQHQYRQEEAEFPTPTGRTITGLRRVLAYLTSFAIFEVGSALCGTAPDMDAPIVRRDIAGMGDRGERGTYITECGLHWGLGAVLGPVVRGGFTSPSLTWRFSFYINLIIAAVFIPGTLLALPSVDPAAGVSLVDRLKRFGLVGLVLGAGTRVAFTMTFTMAGEQWLWADGRTIATIVVFGVLFVLWAVQQTFCIFTTTVDRSVLVHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4Q8</accession>
    <name>B8M4Q8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal recognition particle receptor subunit alpha homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Docking protein alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_025690</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479687.1">
        <property type="nucleotide sequence ID" value="XM_002479642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4Q8"/>
    <dbReference type="FunCoup" id="B8M4Q8">
        <property type="interactions" value="789"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M4Q8"/>
    <dbReference type="GeneID" id="8107981"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_025690"/>
    <dbReference type="eggNOG" id="KOG0781">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_8_1_1"/>
    <dbReference type="InParanoid" id="B8M4Q8"/>
    <dbReference type="OMA" id="HLGWIDK"/>
    <dbReference type="OrthoDB" id="1727884at2759"/>
    <dbReference type="PhylomeDB" id="B8M4Q8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005785">
        <property type="term" value="C:signal recognition particle receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14826">
        <property type="entry name" value="SR_alpha_SRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17876">
        <property type="entry name" value="SRalpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000566">
        <property type="entry name" value="Signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.140:FF:000009">
        <property type="entry name" value="Signal sequence receptor alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000023">
        <property type="entry name" value="Signal sequence receptor alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007222">
        <property type="entry name" value="Sig_recog_particle_rcpt_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04086">
        <property type="entry name" value="SRP-alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="12">
        <location>
            <begin position="617"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="128"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED19253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="644" mass="69679" checksum="D73F84947AB4FF75" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8M567</accession>
    <name>B8M567_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase II Elongator complex associated protein Kti12, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_029490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the KTI12 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480107.1">
        <property type="nucleotide sequence ID" value="XM_002480062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M567"/>
    <dbReference type="FunCoup" id="B8M567">
        <property type="interactions" value="652"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M567"/>
    <dbReference type="GeneID" id="8106516"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_029490"/>
    <dbReference type="eggNOG" id="KOG3062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027147_2_1_1"/>
    <dbReference type="InParanoid" id="B8M567"/>
    <dbReference type="OMA" id="THSRWDK"/>
    <dbReference type="OrthoDB" id="9972657at2759"/>
    <dbReference type="PhylomeDB" id="B8M567"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12435">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="146"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED19673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="429" mass="47345" checksum="F2C370B7A85B2EDA" modified="2009-03-03" version="1">MPLIILTGYPSSGLSYRAKQLAHLLEQTQTQLFDALDNETTDGQAKPKQKRFTFHIVPSHDPGHPRTVYDNARTEKEARAVAYARVKRALAKDAFVILDGMNYIKGYRYQLWCEAKAVGTTCCVVHVGTPIDKCVAINNSRLNRQQRQVNLPDASSNTDDLAEPDTEDPYPSDLHQNLIFRYEEPSTHSRWDKPLFTVPWTDARPPIEEIWTATTGIEIEKNIPPDSTPINPLASLLHTDPNTPSPPSTAQQDTASIAYTIRTTATTNANGSNRLGRPRIKPHQATVLPTQTDSSALYTYEKKTSAIITAIRNYTSSNPSVEAALARSAQIGGVKRADEEGISITVPDSSIAVFIPAHIVRSAPTDDLAGAGGLLTLPRLQRLRRQWISQNRTYIGMTHNQVKGALGSDQVGDAFVRFLNFEFAGDTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8M575</accession>
    <name>B8M575_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_029560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480115.1">
        <property type="nucleotide sequence ID" value="XM_002480070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M575"/>
    <dbReference type="GeneID" id="8106523"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_029560"/>
    <dbReference type="eggNOG" id="ENOG502T2RY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094265_2_0_1"/>
    <dbReference type="InParanoid" id="B8M575"/>
    <dbReference type="OMA" id="VPVSVIW"/>
    <dbReference type="OrthoDB" id="5419608at2759"/>
    <dbReference type="PhylomeDB" id="B8M575"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877549" description="GPI anchored protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="18910" checksum="A3B861E43FB036E1" modified="2009-03-03" version="1">MRPTVFSFYFLLSAVFASAAIEKRDSASPTITSDSSYATISAILGSLASAVSSATPAAGVTPVPAQTANLSNIAEPPAGFIPAIMTAIPLSVLGDLIDSSSRSSLASEFRNGSTPAWYQSLPASIKSYISVVNSQINAGALSANTSAPVVATSTSTAMAMHRVVVPTEVAMGANLLGVLGVAGLAMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5C0</accession>
    <name>B8M5C0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_029970</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOP16 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480160.1">
        <property type="nucleotide sequence ID" value="XM_002480115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5C0"/>
    <dbReference type="FunCoup" id="B8M5C0">
        <property type="interactions" value="266"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M5C0"/>
    <dbReference type="GeneID" id="8106564"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_029970"/>
    <dbReference type="eggNOG" id="KOG4771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078857_0_0_1"/>
    <dbReference type="InParanoid" id="B8M5C0"/>
    <dbReference type="OMA" id="MQQTEAD"/>
    <dbReference type="OrthoDB" id="285729at2759"/>
    <dbReference type="PhylomeDB" id="B8M5C0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019002">
        <property type="entry name" value="Ribosome_biogenesis_Nop16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243">
        <property type="entry name" value="HSPC111 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09420">
        <property type="entry name" value="Nop16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED19726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="249" mass="28495" checksum="E4AE068CC048CED4" modified="2009-03-03" version="1">MGRELQKRKNRAKVPKLKKKRKLLRNGDKKINVLGNALIAENWNKNETLIQNYRRLGLTTRLNAPTGGVERPKGVDALTADKLTSDSLHITGTKNPNATTLFDPEEVQVERDPETGKILRVITNNEEDDEIEVAGRKVKRSNPLSDPINDIENGVKSLHKKAGLDTGSSSSASEFVRQLEMRALQEEEAVKKRRPRQQSKREEEWVERLVARHGDDIKAMVRDKKLNPMQQSEGDIRRRVRIWKERRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5D2</accession>
    <name>B8M5D2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HLH transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_030070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480172.1">
        <property type="nucleotide sequence ID" value="XM_002480127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5D2"/>
    <dbReference type="STRING" id="441959.B8M5D2"/>
    <dbReference type="GeneID" id="8106574"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_030070"/>
    <dbReference type="eggNOG" id="KOG2588">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008057_0_0_1"/>
    <dbReference type="InParanoid" id="B8M5D2"/>
    <dbReference type="OMA" id="RVKTWDI"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="PhylomeDB" id="B8M5D2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        </source>
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</entry>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20643" checksum="D988FE8AB1CCD212" modified="2009-03-03" version="1">MKTQTKDKIALLKENFFPRMKEVDLSDLQDYIYPDPVDWPPFTLREVQVALSSVATRKAPGPDGISNLLEIIYEQCKKWEEKHASKFNPKKFKLIHLLSKYSKITDKEHPVWLDGREVKPVPKCRILGLIIDNKLNWNGHIEHIETKMTKSLGALSSLAGSTWGTGYKGLRQVYQAIILP</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="Proteomes" id="UP000001745">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF337">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="55"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="396"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="570"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="570"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="583"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="621"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="678"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="707"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED20147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="729" mass="82067" checksum="132D3A6523C3BB19" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8M710</accession>
    <name>B8M710_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-carboxymuconate cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_034670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480664.1">
        <property type="nucleotide sequence ID" value="XM_002480619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M710"/>
    <dbReference type="STRING" id="441959.B8M710"/>
    <dbReference type="GeneID" id="8104309"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_034670"/>
    <dbReference type="eggNOG" id="ENOG502S2T1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037887_1_0_1"/>
    <dbReference type="InParanoid" id="B8M710"/>
    <dbReference type="OMA" id="TCWATIS"/>
    <dbReference type="OrthoDB" id="10006285at2759"/>
    <dbReference type="PhylomeDB" id="B8M710"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877354" description="3-carboxymuconate cyclase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="40096" checksum="387B140A9E2AB788" modified="2009-03-03" version="1">MLVSFKSCITNALLVLLATAHPLDAGHRSCEAPSGAKAIYFLTNEHSNSVVAIAVGANGTLSGGVKVATGGNGGSTVNSTGGSNGPDALGSQSALTVVDNYLFAVNPGSNTLSMMKIASTDATDLKLIGKPVAVSGQFPVTVAASSKNRLVCVGTTGAQAAISCASYTSKGLGSMSTRAVFDLNQTTPPSGPLNGVAHTFFSADETRLFTTVKGDPTSNKTGFVSVLPIENPSAKDTRSSPNGTAVLFGASVLPGTSNIFVTDASFGAGIFHVNPSTNDVSLVSKAAIQDQKATCWAAFSKQRGSVFVSDVANNHLVEMSAVDSHIISTVNLDNGDPGLIDLKVSGRFVYALSPGNGTTPAAVTVVDSSVGKQIQHFHVSQLGAGKSSQGMAVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7X5</accession>
    <name>B8M7X5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_031170</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480288.1">
        <property type="nucleotide sequence ID" value="XM_002480243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7X5"/>
    <dbReference type="STRING" id="441959.B8M7X5"/>
    <dbReference type="GeneID" id="8107728"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_031170"/>
    <dbReference type="eggNOG" id="KOG2246">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8M7X5"/>
    <dbReference type="OMA" id="ERTRPYN"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="PhylomeDB" id="B8M7X5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF43">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="12">
        <location>
            <begin position="187"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED19854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="500" mass="58296" checksum="0D8A36C63F694BAB" modified="2009-03-03" version="1">MRLLIRHQYLSLVPVAALFFIFGTIYSTHRWESTRQLNKDQWTQRLGNQGTQQSHNGQNYDDPNCVDFPRDRLRDIQIVFRIGSTQPFDQISSHINNITNCISNLIVISDRVEEIGNGFWSHDIIADLPKVYWEGIDKDDDETDQTAGLKAYANINKGDSSWKQGKYASDRLTHRQGWLLDRFKFLPMVEYAYNVNPQAKWFYFIEADTYVVWDTLFQLLEQYDSRQAWYMGSPSPGRQLHGETTWFAYGGDGFILSRSAIQRLVTKDPVKDEESNNTNRTELSLTERWADIVKSDCCGDSVLGYALVRKGILLSGLYPIFNPHPLHGIPFGPSGKPYWCQPVLSLHKTWPGDVSALTQFVKHRSNEQTLIYADLFYYLNLDRLKPRENWQNSDWNGFEEGPESPVHESIEACVDGCHTHNECFQWTYWTETSWEWNSVPKKKCTFVRSIRLGSRRDREESWTTTVTWTSGWDIEKISTWATENRCEKPEWVEPSSERIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7Y2</accession>
    <name>B8M7Y2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">allantoicase</fullName>
            <ecNumber evidence="3">3.5.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_031230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Utilization of purines as secondary nitrogen sources, when primary sources are limiting.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>allantoate + H2O = (S)-ureidoglycolate + urea</text>
            <dbReference type="Rhea" id="RHEA:11016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="3.5.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Nitrogen metabolism; (S)-allantoin degradation; (S)-ureidoglycolate from allantoate (aminidohydrolase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the allantoicase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.4" evidence="3"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480295.1">
        <property type="nucleotide sequence ID" value="XM_002480250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7Y2"/>
    <dbReference type="FunCoup" id="B8M7Y2">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M7Y2"/>
    <dbReference type="GeneID" id="8107734"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_031230"/>
    <dbReference type="eggNOG" id="KOG4145">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038797_0_0_1"/>
    <dbReference type="InParanoid" id="B8M7Y2"/>
    <dbReference type="OMA" id="MDDGWET"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="PhylomeDB" id="B8M7Y2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004037">
        <property type="term" value="F:allantoicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000078">
        <property type="entry name" value="DAL2p Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000059">
        <property type="entry name" value="Probable allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00813">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005164">
        <property type="entry name" value="Allantoicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02961">
        <property type="entry name" value="allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045">
        <property type="entry name" value="ALLANTOICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045:SF3">
        <property type="entry name" value="INACTIVE ALLANTOICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016516">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Allantoicase" evidence="8">
        <location>
            <begin position="70"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Allantoicase" evidence="8">
        <location>
            <begin position="250"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED19861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="401" mass="43849" checksum="DA2B9585C03DCB02" modified="2009-03-03" version="1">MVVHRRHIPNHSIDLSGLLKMEAPTVPVDKAAELSGITTSGKVTVTRVPNDSIDKTFARTTNLASSALNARILSKSNDYFAAAENLLTPTPPIHKPGVFVHTGAWYDGWETRRHNPEPYDWVVIKLGVSSGAIEGVEVDTAYFVGNYGEKAELQGTYAPAGSADSDEQIASPDYKGWKTILPVVECGPSQRRAWRIDSYDAKNPTPYTHVRLLMYPDGGFARLRLYGHAIPPPVAAASSTEEELSSALVGGLALSASDQHYTPASNTILPGRGKDMGDGWETARSRTPGHVDWAIFRLGLPGTVHKIVVDTKDFRGNFPREVRVHGLVKDDATKDEDVTNEHPGWIELLNGDKKTQADTEHVFEGAELAVGKGDERVFSHVKLTLVPDGGVKRFRVFGQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8D6</accession>
    <name>B8M8D6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase, short-chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_036720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480883.1">
        <property type="nucleotide sequence ID" value="XM_002480838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8D6"/>
    <dbReference type="STRING" id="441959.B8M8D6"/>
    <dbReference type="GeneID" id="8100518"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_036720"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8M8D6"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="PhylomeDB" id="B8M8D6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF16">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED20449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="320" mass="35069" checksum="1AD3BC73B4CE4AB2" modified="2009-03-03" version="1">MIANEPKSLGCIYKSFGLWKKNHAIKEMKQHGTFQPPRVPQSQTKPGLETNMQPASESTKLEDADGFFEYVGSGKLKDKSVLITGGDSGIGRAVAVLMAREGADVTIAHLPEEQEDAEDTKKMVEAEKRSCFLFAGDLTDHENCRRVVDEHYRSYGSLNILVNNASKQYMCKTLTDIDLNTVESVFRSNILQMFAVTKYALTYMKQGDTIINTTSVVTFRGSASMVDYAATKGAIVGFTRSLATQLIPKGIRVNAVAPGAIYTPIQPDTRPAKQMEGWHSKSPLGRPGQPSEVAPTFVFLASPEASLYCELSAISCYVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8E1</accession>
    <name>B8M8E1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carboxylesterase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_036760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480888.1">
        <property type="nucleotide sequence ID" value="XM_002480843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8E1"/>
    <dbReference type="STRING" id="441959.B8M8E1"/>
    <dbReference type="GeneID" id="8100522"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_036760"/>
    <dbReference type="eggNOG" id="ENOG502SE29">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_3_0_1"/>
    <dbReference type="InParanoid" id="B8M8E1"/>
    <dbReference type="OMA" id="SERMERC"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="PhylomeDB" id="B8M8E1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002874837" evidence="2">
        <location>
            <begin position="29"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="76"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED20454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="307" mass="33953" checksum="3132B8659E585588" modified="2009-03-03" version="1">MSDFWAFTRYLYLKVLVTLSRLLIKLLASPQSSKLDYKLDIPSRDKNRTIKVHVYKPPVTETGSSTPAPVLINLYGSGLAIPLHGLDDDFCRFIADTTGYVVLDVNYCLAPEYPFPKALNDVEDTLKYVLDHPKEYQASRVSISGFSSGGTLALSASASLPRGTFTSLIAFYPATNLYQDPSLRKAPVPGGKDRSPFWTRIFRESYIRGMDARDPRISPAFADTTNFPSNMLIVTGELDASAIEAEELAERAKDEGHTTGREVIIRRMKGCGHAFDKKLTGEVSVKAKNETYELAAKILKNGLKVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8S0</accession>
    <name>B8M8S0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH-ubiquinone oxidoreductase 299 kDa subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_037970</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFA5 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481017.1">
        <property type="nucleotide sequence ID" value="XM_002480972.1"/>
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    <dbReference type="eggNOG" id="ENOG502S4WS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084284_0_0_1"/>
    <dbReference type="InParanoid" id="B8M8S0"/>
    <dbReference type="OMA" id="WTYFERG"/>
    <dbReference type="OrthoDB" id="286811at2759"/>
    <dbReference type="PhylomeDB" id="B8M8S0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006806">
        <property type="entry name" value="NDUFA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-B SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04716">
        <property type="entry name" value="ETC_C1_NDUFA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED20583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="241" mass="27034" checksum="B8C7F301E047CE52" modified="2009-03-03" version="1">MRPALRLLANVKQARYLEPFAPTGLTGLVTHPSPRSTLIFLYTQTLEKLKQFPESSAYRQSTEALTRHRLSIIESTKPPGFDEWLQRVKKVVAENPEQFKKARLANGIFAGIQQDDIHGGTKAQEWDGAVGPITEGPTRTPEEVAQWEKILEEATQPESASDFHQETINWESEPSLEAQQIADIENKIGAGLIEEVIQVAEGELNLVDELAKAKVWEELAEKPQPGQWTYFSRDTHTPGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8M992</accession>
    <name>B8M992_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Efflux pump antibiotic resistance protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_112200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481379.1">
        <property type="nucleotide sequence ID" value="XM_002481334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M992"/>
    <dbReference type="GeneID" id="8098875"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_112200"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="InParanoid" id="B8M992"/>
    <dbReference type="OMA" id="HASTGQW"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="PhylomeDB" id="B8M992"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF187">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="507"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="42"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED17387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="542" mass="58359" checksum="CC000FDDDDE63817" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8MA07</accession>
    <name>B8MA07_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7605 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_119230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482151.1">
        <property type="nucleotide sequence ID" value="XM_002482106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MA07"/>
    <dbReference type="STRING" id="441959.B8MA07"/>
    <dbReference type="GeneID" id="8104373"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119230"/>
    <dbReference type="eggNOG" id="ENOG502QU12">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036528_0_0_1"/>
    <dbReference type="InParanoid" id="B8MA07"/>
    <dbReference type="OMA" id="MINHVEN"/>
    <dbReference type="OrthoDB" id="3598281at2759"/>
    <dbReference type="PhylomeDB" id="B8MA07"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056024">
        <property type="entry name" value="DUF7605"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681:SF3">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24564">
        <property type="entry name" value="DUF7605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7605" evidence="2">
        <location>
            <begin position="42"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED18159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="387" mass="42896" checksum="356D2CCC2498F51A" modified="2009-03-03" version="1">MQELVQHIKNICDQIAEEIESDITEACNKATPTAAKLATETVSRWGAPVNRSNRAEGGYYWATYKALCRRDGVYANAQGQHDWNAELIEPIIKAVAPGWEKIFSRRIFTIFSNAGSEGANFLKKFHDNVYKKITQTTGPLGSIHMLSQQLRVYQQSVKELFNQQALDISAQSKDINRMFEPVIVESMIPAYTSCVEERGPGSFMRMKATMSSHVSDNRDSMFEKSVDVVEAALNRMLESVEEALLASTDTTLMSLKRDYRSAVVGSQSAAGGILPREKRAALQELLKHIMESETSYKELIQPEIKKDVSSEAVADVQDQETTPELKENPVLVKKEGATETLLSSSAAASPIKQEPTDAVSFENHEIKIKPDPDDDDMANSQLAAGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MA11</accession>
    <name>B8MA11_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_120840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482332.1">
        <property type="nucleotide sequence ID" value="XM_002482287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MA11"/>
    <dbReference type="STRING" id="441959.B8MA11"/>
    <dbReference type="GeneID" id="8100068"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_120840"/>
    <dbReference type="eggNOG" id="ENOG502SIT3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004083_7_3_1"/>
    <dbReference type="InParanoid" id="B8MA11"/>
    <dbReference type="OMA" id="GYVQWHS"/>
    <dbReference type="OrthoDB" id="4226956at2759"/>
    <dbReference type="PhylomeDB" id="B8MA11"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF50">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="109"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED18340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="432" mass="49002" checksum="328047450495BFC1" modified="2009-03-03" version="1">MAVSLSVFHPTMAHRRILWNVFEENVIPVVMIFHKPSIRDIMASVAADGSGIDRALEAVIFAVYFAAVTSMDPEQCAETLGEDHSYLQQHYRTTLFLTCLRAPEDAAFVWTMTAAVHRMAQGLGLHRDGTYFGLSPFEVEIRRRLWWSIYLLDSRSSEFRAIGPQITEHSYDTRLPLNIDDSALSPDSIEAPEEKVGFTEMTFCLARCEMIVRHRRFHLNIHSGTSSSQGEQTSHQLGERMHALEQISGQLQDRYLRSCDVSVPIQWVTATVIRLALARSWLIAHLPERVTAEEITLRGTSSVQDPTREQLFQTAVEVLEFAYLLDTDPRTKQWSWFFESYPQWHSVVFVLSELCARPRTILTDRAWAVTVRAVARWTNTDFRKGGITLKIILQLMEQAATAHGRVWAGIGTQTSPLSGVSQESDGQMLYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAY2</accession>
    <name>B8MAY2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein kinase Yak1, putative</fullName>
            <ecNumber evidence="13">2.7.12.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_124120</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="13"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482675.1">
        <property type="nucleotide sequence ID" value="XM_002482630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAY2"/>
    <dbReference type="FunCoup" id="B8MAY2">
        <property type="interactions" value="341"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MAY2"/>
    <dbReference type="GeneID" id="8098363"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_124120"/>
    <dbReference type="eggNOG" id="KOG0667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_88_1_1"/>
    <dbReference type="InParanoid" id="B8MAY2"/>
    <dbReference type="OMA" id="QPYQDPL"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="PhylomeDB" id="B8MAY2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14212">
        <property type="entry name" value="PKc_YAK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000087">
        <property type="entry name" value="Dual specificity tyrosine-phosphorylation-regulated kinase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000380">
        <property type="entry name" value="Serine/threonine-protein kinase ppk15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF17">
        <property type="entry name" value="HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="345"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="836"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="862"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED18683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="898" mass="100125" checksum="5D0BDBE26A321911" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MB93</accession>
    <name>B8MB93_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Raffinose synthase protein Sip1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_125940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha-D-galactosyl-(1-&gt;3)-1D-myo-inositol + sucrose = raffinose + myo-inositol</text>
            <dbReference type="Rhea" id="RHEA:20161"/>
            <dbReference type="ChEBI" id="CHEBI:16634"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:17505"/>
            <dbReference type="ChEBI" id="CHEBI:17992"/>
            <dbReference type="EC" id="2.4.1.82"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolases 36 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482874.1">
        <property type="nucleotide sequence ID" value="XM_002482829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MB93"/>
    <dbReference type="STRING" id="441959.B8MB93"/>
    <dbReference type="GeneID" id="8098106"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_125940"/>
    <dbReference type="eggNOG" id="ENOG502QPVE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006630_0_0_1"/>
    <dbReference type="InParanoid" id="B8MB93"/>
    <dbReference type="OMA" id="AGWSNEV"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="PhylomeDB" id="B8MB93"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047274">
        <property type="term" value="F:galactinol-sucrose galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000222">
        <property type="entry name" value="Raffinose synthase Sip1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008811">
        <property type="entry name" value="Glycosyl_hydrolases_36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31268">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31268:SF32">
        <property type="entry name" value="GALACTINOL--SUCROSE GALACTOSYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05691">
        <property type="entry name" value="Raffinose_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED18882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="958" mass="106095" checksum="13684875426EC30F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBC1</accession>
    <name>B8MBC1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Polyketide synthase, putative</fullName>
            <ecNumber evidence="10">2.3.1.94</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_126190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.94" evidence="10"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482902.1">
        <property type="nucleotide sequence ID" value="XM_002482857.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MBC1"/>
    <dbReference type="GeneID" id="8098131"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_126190"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_6_1_1"/>
    <dbReference type="InParanoid" id="B8MBC1"/>
    <dbReference type="OMA" id="CKTWDAT"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="PhylomeDB" id="B8MBC1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047879">
        <property type="term" value="F:erythronolide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000017">
        <property type="entry name" value="Non-reducing polyketide synthase aptA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000002">
        <property type="entry name" value="Probable polyketide synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000011">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.110:FF:000001">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000031">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030918">
        <property type="entry name" value="PT_fungal_PKS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04532">
        <property type="entry name" value="PT_fungal_PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="8">
        <location>
            <begin position="403"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="9">
        <location>
            <begin position="1331"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1708"/>
            <end position="1785"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="5">
        <location>
            <begin position="1331"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="5">
        <location>
            <begin position="1494"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1661"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1672"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="5">
        <location>
            <position position="1363"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="5">
        <location>
            <position position="1552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED18910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1786" mass="195188" checksum="E6345738B5D74AA2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBD9</accession>
    <name>B8MBD9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_126360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482920.1">
        <property type="nucleotide sequence ID" value="XM_002482875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBD9"/>
    <dbReference type="GeneID" id="8099063"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_126360"/>
    <dbReference type="HOGENOM" id="CLU_1971954_0_0_1"/>
    <dbReference type="InParanoid" id="B8MBD9"/>
    <dbReference type="OrthoDB" id="4363062at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED18928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="127" mass="14741" checksum="1BEAF475A1FE3ADD" modified="2009-03-03" version="1">MPNLEPSGNITKINSLEWRGLHEISYDVYVYITEGDSEVTSLPETQYRVSGRVRKRLRVIKAKQVDLQILIYAPRDLMMFALFYYPEGRVMALRNLRGPGRGPGRQGDPRVVARSMWKSVFKQRPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBP6</accession>
    <name>B8MBP6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytanoyl-CoA dioxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_119410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482171.1">
        <property type="nucleotide sequence ID" value="XM_002482126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBP6"/>
    <dbReference type="STRING" id="441959.B8MBP6"/>
    <dbReference type="GeneID" id="8105216"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119410"/>
    <dbReference type="eggNOG" id="ENOG502SK8A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056749_0_0_1"/>
    <dbReference type="InParanoid" id="B8MBP6"/>
    <dbReference type="OMA" id="SFARCYF"/>
    <dbReference type="OrthoDB" id="2106152at2759"/>
    <dbReference type="PhylomeDB" id="B8MBP6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40470">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G15850)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40470:SF1">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G15850)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED18179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="336" mass="37462" checksum="7F2828FCC3B29BA4" modified="2009-03-03" version="1">MTDKRKANMTDASPYLSSLQRDGFVVIPSLLSSPEITTLRDAATKATTLTRTGQWPYFRTVPKQFPPWPKDVPPASEGGIWGVQHLLHPDMPGRREFAKFYFSEKVLGIVEELLGLKATNNIQKGSGEEEEPLVMELLNLLVAPETRDFELRWHRDDIPPTVTPEEELQLLKSKSPQGRQSHAQYNLALCPDTSLIVIPGSHRRVRTETERNADPYEAELPGQLTVRLEPGDAVFYDSNILHRGVYKPKPEGGEETRLTLHGSVGLNQTSITKDGDTEAAADKAKVRATAVLQHGVGIWIDRDDADLSYTSDRAERMRRNLIAMGRGENVGFSLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBY7</accession>
    <name>B8MBY7_TALSN</name>
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        <recommendedName>
            <fullName evidence="3">UFSP1/2/DUB catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_121720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482425.1">
        <property type="nucleotide sequence ID" value="XM_002482380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBY7"/>
    <dbReference type="STRING" id="441959.B8MBY7"/>
    <dbReference type="GeneID" id="8098161"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_121720"/>
    <dbReference type="eggNOG" id="KOG4696">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013053_3_0_1"/>
    <dbReference type="InParanoid" id="B8MBY7"/>
    <dbReference type="OMA" id="PFCPFSD"/>
    <dbReference type="OrthoDB" id="288987at2759"/>
    <dbReference type="PhylomeDB" id="B8MBY7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012462">
        <property type="entry name" value="UFSP1/2_DUB_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07910">
        <property type="entry name" value="Peptidase_C78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UFSP1/2/DUB catalytic" evidence="3">
        <location>
            <begin position="254"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED18433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="481" mass="54103" checksum="BF38DD71631DC396" modified="2009-03-03" version="1">MSDPDTKEQVLLSCPFCEFEEYDSEFLSQHVAYCHPEDPDVASQSTYTHQSLTAAEEDRRATQADESLTVLDNMEDLYTPCPHGCGETVAKAELQLHLDLHVAESIALNETGGLHLQSVDSDDDGRIDRSSEDKNGNDDEDLHQDDLVVHGKDIVLKGKDTDNHRRKKKDVSKSSQHGNKGTRRLGRKELGPYAHEKRMPSWLQKLLLSGHIENTQTKIGPNGSLIKEKDLSENETSRVIPTLIELCRHDTSIQRAFFCSPRVRHIFKFMREGGFCGYRNIQMLISHIIDARRPGYEHFSGRIPSILELQDMIEQAWDMGFNSSGRIETGGIKGTRKYIGTPEAQALFQSLGIKCIPGAFASTGGFRAYDMLLQDVANYFRSGCPASLLDSDEKILETDLPPVYLQHQGHSLTIVGFEINSAGSADLLVFDPMFRTSPAIQRLIGKFVRPSDPSRILKAWRRGPPYLQKYKEFEVLKLVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MC44</accession>
    <name>B8MC44_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SIP5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Protein sip5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_122260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May negatively regulate the SNF1 kinase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SIP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482482.1">
        <property type="nucleotide sequence ID" value="XM_002482437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MC44"/>
    <dbReference type="FunCoup" id="B8MC44">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MC44"/>
    <dbReference type="GeneID" id="8097691"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_122260"/>
    <dbReference type="eggNOG" id="KOG2789">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009068_1_0_1"/>
    <dbReference type="InParanoid" id="B8MC44"/>
    <dbReference type="OMA" id="CFLTYPP"/>
    <dbReference type="OrthoDB" id="21471at2759"/>
    <dbReference type="PhylomeDB" id="B8MC44"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24139">
        <property type="entry name" value="SIP5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039301">
        <property type="entry name" value="Sip5/DA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315">
        <property type="entry name" value="PROTEIN SIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315:SF1">
        <property type="entry name" value="PROTEIN SIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="151"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="194"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="315"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="384"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="459"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="504"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="556"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="558"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="594"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="642"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="672"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="692"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="735"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="757"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="781"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED18490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="819" mass="88425" checksum="AF7F5A6110D2F1DE" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MC68</accession>
    <name>B8MC68_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_122470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482506.1">
        <property type="nucleotide sequence ID" value="XM_002482461.1"/>
    </dbReference>
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    <dbReference type="STRING" id="441959.B8MC68"/>
    <dbReference type="GeneID" id="8097712"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_122470"/>
    <dbReference type="HOGENOM" id="CLU_1349699_0_0_1"/>
    <dbReference type="InParanoid" id="B8MC68"/>
    <dbReference type="OrthoDB" id="197419at2759"/>
    <dbReference type="PhylomeDB" id="B8MC68"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
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    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
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        <property type="match status" value="2"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="203" mass="22672" checksum="DFADC65DFFCA4A14" modified="2009-03-03" version="1">MNYVYWKHFPIHNASRYGLRSMPTFSGPYATSWKAPLLSAYIEGRLNNCTPLTLAIAHGHAEVCQYLVDGFKEIRKNAPRDFWITNIRNGEDIIKGIYSNINSCQALPLYGPFKDYQGAHGETALYAAASSRNYSAVSFLLQKKANVNIPKKSRGWNPPSSSPLSNDMGRLHSSLNPAQIKIIGIVLVGEQFIMQKLGVIRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCF7</accession>
    <name>B8MCF7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_124920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002482720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCF7"/>
    <dbReference type="STRING" id="441959.B8MCF7"/>
    <dbReference type="GeneID" id="8100271"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_124920"/>
    <dbReference type="eggNOG" id="ENOG502RX0Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_530162_0_0_1"/>
    <dbReference type="InParanoid" id="B8MCF7"/>
    <dbReference type="OMA" id="RRRVWCG"/>
    <dbReference type="OrthoDB" id="3862662at2759"/>
    <dbReference type="PhylomeDB" id="B8MCF7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED18773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="57731" checksum="F2A6639A727A6F70" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCY0</accession>
    <name>B8MCY0_TALSN</name>
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        <recommendedName>
            <fullName evidence="2">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_113320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481498.1">
        <property type="nucleotide sequence ID" value="XM_002481453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCY0"/>
    <dbReference type="STRING" id="441959.B8MCY0"/>
    <dbReference type="GeneID" id="8101644"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_113320"/>
    <dbReference type="HOGENOM" id="CLU_518848_0_0_1"/>
    <dbReference type="InParanoid" id="B8MCY0"/>
    <dbReference type="OMA" id="KYWHVYT"/>
    <dbReference type="OrthoDB" id="5424234at2759"/>
    <dbReference type="PhylomeDB" id="B8MCY0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED17506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="515" mass="56346" checksum="D9E1905632814045" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEQ0</accession>
    <name>B8MEQ0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Small oligopeptide transporter, OPT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_019920</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484167.1">
        <property type="nucleotide sequence ID" value="XM_002484122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEQ0"/>
    <dbReference type="GeneID" id="8108803"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_019920"/>
    <dbReference type="eggNOG" id="KOG2262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004965_1_1_1"/>
    <dbReference type="InParanoid" id="B8MEQ0"/>
    <dbReference type="OMA" id="DAIHWPI"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="PhylomeDB" id="B8MEQ0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="480"/>
            <end position="506"/>
        </location>
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        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="566"/>
            <end position="587"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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        </location>
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        </location>
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        <location>
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        </location>
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            <end position="11"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED16933.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="774" mass="86538" checksum="6FDA14582F068427" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFB1</accession>
    <name>B8MFB1_TALSN</name>
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        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">TSTA_017200</name>
    </gene>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED16645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="441959.B8MFB1"/>
    <dbReference type="GeneID" id="8103693"/>
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    <dbReference type="eggNOG" id="KOG1075">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_919979_0_0_1"/>
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    <dbReference type="OrthoDB" id="4362013at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="162"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="332" mass="37995" checksum="D9A3EC6553B2E7EF" modified="2009-03-03" version="1">MEENDLAEKGFEIEDIAWLKKKDRPLGKAASMGIWLNTPEAAESIINNGLLVGQRYIGKQVKCGHCSGQHDQHNCPLGIRPRAGMEALINDHQSQNLNLLLIQEPSVTTYRTHVNHSAWRLYQPTYLNTNESTRYRSLIYVNKRILTSSYRQIQCNHPDLFLIFSVYIPPLDAHQATSTTAAELILAEIKNTIEEYTKEPNKTTRLILAGDFNRHHPAWSHRLVSHVFTSQAEELINFFQTYKLQWCLPPGTPTYWSPSLPGKASVLDLTLTNDPAKLMKCQLYRDNYGSDYHGTYSEWDLRPECNKNPKPKRAYDRADWDKIGSALLELLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHE8</accession>
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            <fullName evidence="4">60S ribosomal protein L29</fullName>
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        <name evidence="6" type="ORF">TSTA_021840</name>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL29 family.</text>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="441959.B8MHE8"/>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_021840"/>
    <dbReference type="eggNOG" id="KOG3504">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169255_2_0_1"/>
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    <dbReference type="OMA" id="PRTNKYP"/>
    <dbReference type="OrthoDB" id="996720at2759"/>
    <dbReference type="PhylomeDB" id="B8MHE8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002673">
        <property type="entry name" value="Ribosomal_eL29"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L29e"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED17127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="65" mass="7580" checksum="7F9A91F0698B8FB0" modified="2009-03-03" version="1">MAKSKNSSQHNQSKKAHRNGIKKPKTYRYPSLKGTDPKFRRNHRHALHGTMKALKERKEGKREVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8MI17</accession>
    <name>B8MI17_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Homeobox and C2H2 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_022330</name>
    </gene>
    <organism evidence="7 8">
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        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484413.1">
        <property type="nucleotide sequence ID" value="XM_002484368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MI17"/>
    <dbReference type="STRING" id="441959.B8MI17"/>
    <dbReference type="GeneID" id="8107070"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_022330"/>
    <dbReference type="eggNOG" id="KOG0773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020539_0_0_1"/>
    <dbReference type="InParanoid" id="B8MI17"/>
    <dbReference type="OMA" id="LDSWVCT"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="PhylomeDB" id="B8MI17"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="233"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="235"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="283"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED17179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="595" mass="67520" checksum="71B0A14CB2972FC6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MI26</accession>
    <name>B8MI26_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_022420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484422.1">
        <property type="nucleotide sequence ID" value="XM_002484377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MI26"/>
    <dbReference type="GeneID" id="8107079"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_022420"/>
    <dbReference type="eggNOG" id="KOG3098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030884_2_0_1"/>
    <dbReference type="InParanoid" id="B8MI26"/>
    <dbReference type="OMA" id="NTWFPIL"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="PhylomeDB" id="B8MI26"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF59">
        <property type="entry name" value="UNC93-LIKE PROTEIN C922.05C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED17188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="44862" checksum="4DFED1350D59AC03" modified="2009-03-03" version="1">MTVLGFISGLVCNRIGVRWTLVIGTLGYAPYAAALYTNAAFGNTWFPILGAATCGISAVFLWTASGAINLVVPFVHHRGRAVATKFAFQNVGGFIGGAISLGLNINQNRAGRVSDATYFAFISIMCLGLPLAATIPRPSRVKRSDGSRVVEHRFKSWNEELLSLKSVLSLKGFLLLVPFALYCQWDLSYMWGWNAVYHTVRARALLSTLFYLVGPTILGPVQGWLMDRKRWSRRTRARYGMTIYTIVTALTWVYGLIVQYQYDKREAATAIDIVDPVFVKSCLLFILYGLIENSGMMVIYWLIGSLGLDPGKVASIVGLVTGIGSFGSTMAFVLGACNVSLKWQLWANVIAFLASLPGLLYVSWTMITEDDKLEEATTANYSITSLEDSVEQNIPEVYTKRGETSSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIS5</accession>
    <name>B8MIS5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_050270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>precorrin-2 + NAD(+) = sirohydrochlorin + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="2"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485542.1">
        <property type="nucleotide sequence ID" value="XM_002485497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIS5"/>
    <dbReference type="FunCoup" id="B8MIS5">
        <property type="interactions" value="118"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MIS5"/>
    <dbReference type="GeneID" id="8108789"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_050270"/>
    <dbReference type="eggNOG" id="ENOG502RYIW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011276_8_5_1"/>
    <dbReference type="InParanoid" id="B8MIS5"/>
    <dbReference type="OMA" id="TQIWKLC"/>
    <dbReference type="OrthoDB" id="1721126at2759"/>
    <dbReference type="PhylomeDB" id="B8MIS5"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.110">
        <property type="entry name" value="Siroheme synthase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3280.10">
        <property type="entry name" value="Siroheme synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330:SF1">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="8">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="7">
        <location>
            <begin position="187"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED15589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="264" mass="28809" checksum="583B87E0F37FE34B" modified="2009-03-03" version="1">MKLSADNCFFKTSSSINSLQLRYSLSKMSQKFPEVQGGGSLIVAWQVRNKNVLVVGGGEVASGRILHALNADANVTVVCPSSGLNEEVAYRVAENQVSHIDRNFEPHDLDNADMVLCAIDDPEASTQVWKLCKERRIPANIADVPPECDFYFGSMHRDGPLQIMVSTNGNGPKLANIVRQKIASALPQNTGAAIENVGLLRKKLRAIAPDANEGPKRMKWMSNVCVSWSLEDLVAMTDKDMDGLLTHYQSGDVPSLQDIRAALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIX1</accession>
    <name>B8MIX1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_050710</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485586.1">
        <property type="nucleotide sequence ID" value="XM_002485541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIX1"/>
    <dbReference type="FunCoup" id="B8MIX1">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MIX1"/>
    <dbReference type="GeneID" id="8109113"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_050710"/>
    <dbReference type="eggNOG" id="KOG0770">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_3_2_1"/>
    <dbReference type="InParanoid" id="B8MIX1"/>
    <dbReference type="OMA" id="FFGVYEF"/>
    <dbReference type="OrthoDB" id="415315at2759"/>
    <dbReference type="PhylomeDB" id="B8MIX1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990616">
        <property type="term" value="P:magnesium ion export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000095">
        <property type="entry name" value="Mitochondrial carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="90"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="198"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="225"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="251"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED15633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="355" mass="38650" checksum="E62E9782D227637B" modified="2009-03-03" version="1">MLAGGIGGSSGDMLMHSLDTVKTRQQGDPHMPPRYGSTSASYLKIFREEGFRRGLYSGVSPALMGSFPGTVIFFGTYEWSKRHMIDAGINPTISYLSAGFIADLAASVVYVPSEVLKTRLQLQGRYNNPYFKSGYNYRGTVDAFRTIVRTEGFGAMFSGYKATIFRDLPFSALQFAFYEQEQEWAKNWVGSRDIGLTLEILTATTAGGMAGVLTCPLDVVKTRIQTQQNPDASPQKSSQASVSSKKDSRPHGPSQHTSSSSSSPSSSSSKTHSRPISTSSPSTSTPQPGAPILRTSSVFTGLRLIYKTEGFAGWFRGVGPRAVWTSVQSGTMLVMYQYLLKKLESLQESETAPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJ24</accession>
    <name>B8MJ24_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_051240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485639.1">
        <property type="nucleotide sequence ID" value="XM_002485594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJ24"/>
    <dbReference type="GeneID" id="8106326"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_051240"/>
    <dbReference type="eggNOG" id="ENOG502RQI6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_26_1_1"/>
    <dbReference type="InParanoid" id="B8MJ24"/>
    <dbReference type="OrthoDB" id="4357294at2759"/>
    <dbReference type="PhylomeDB" id="B8MJ24"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="163" mass="17693" checksum="BBC707FA4509C696" modified="2009-03-03" version="1">MAFQRTIPSSDIFLRSSLSYGHGKEVFDVEVEAALAGAQAAIAYPTAQFTTNLWICLDNLEVAICLLSPSTGSSQEIFESFRTLAAVWPLRKRLPHTKSGSIQIRWVPGHAKIPENEAADLAAKEGAASIPPAPYKSSYASLKRYAKTQSLSAAQSQWQKVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJ92</accession>
    <name>B8MJ92_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Long-chain-fatty-acid-CoA ligase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_041590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484634.1">
        <property type="nucleotide sequence ID" value="XM_002484589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJ92"/>
    <dbReference type="FunCoup" id="B8MJ92">
        <property type="interactions" value="589"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MJ92"/>
    <dbReference type="GeneID" id="8109744"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_041590"/>
    <dbReference type="eggNOG" id="KOG1177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_7_1"/>
    <dbReference type="InParanoid" id="B8MJ92"/>
    <dbReference type="OMA" id="ELNMTEY"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="PhylomeDB" id="B8MJ92"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000003">
        <property type="entry name" value="Long-chain-fatty-acid--CoA ligase FadD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF6">
        <property type="entry name" value="ACYL COA SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="58"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="490"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED14681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="598" mass="66485" checksum="D2E574FB80DAD281" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJC0</accession>
    <name>B8MJC0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS sugar transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_041850</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484662.1">
        <property type="nucleotide sequence ID" value="XM_002484617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJC0"/>
    <dbReference type="GeneID" id="8102962"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_041850"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="InParanoid" id="B8MJC0"/>
    <dbReference type="OMA" id="FMQTFAP"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="PhylomeDB" id="B8MJC0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
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        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF46">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G11830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="16"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="208"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED14709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="504" mass="55917" checksum="DE7D3E0AA717CFE9" modified="2009-03-03" version="1">MAVTPFHSKRVYNWYISCIAAACMVLYGYDASVFNSVQGSARWKAWFNHPSSSLIGTINTVYSVGAIVGGFFFGGPLSDYLGRKVGMGIGCMFVIVATFMQAFAPYHSIGCFLAGRCLIGIGQGIALTSGPIYIGELAPPHIRGKIMTLWQTFYSVGSFICFWVNYGCTKHTSRLGEWDWKMVVIFQLLVPVIILTLLPTIPGTPRWYIQKNNNIDKARAALRRVRETEEEVEEELTQIRGALEYEKEAISSSYSALWKDHSIRKRLLLALVINAGQQLTGQGSLNSYSTIIYQKVFSSASQIALINALNATFGILFTLNAIWMVDRFGRKFLLIVGGIGMGLVMIMVAAVETETPTLPNGAKTQSVGIALVFLLFFFIFFYKPSWGATVWIWTSEVFSMNVRAQAVGMASQTQNVANTIFQQFFPTFLKHDGFYAFYFFAGINMLLAAFVYFFIPETKNVSLEEIDVLFGGANHSAQGENMLAESKLHGAAHIEHIPAGKPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJZ6</accession>
    <name>B8MJZ6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCP-like extracellular protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_042860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484766.1">
        <property type="nucleotide sequence ID" value="XM_002484721.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484767.1">
        <property type="nucleotide sequence ID" value="XM_002484722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJZ6"/>
    <dbReference type="STRING" id="441959.B8MJZ6"/>
    <dbReference type="GeneID" id="8104763"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_042860"/>
    <dbReference type="eggNOG" id="KOG3017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035730_5_0_1"/>
    <dbReference type="InParanoid" id="B8MJZ6"/>
    <dbReference type="OMA" id="NHNVHRS"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000018">
        <property type="entry name" value="SCP-like extracellular protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007645149" evidence="2">
        <location>
            <begin position="18"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="144"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED14813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="308" mass="32125" checksum="5191BAB843786D2D" modified="2009-03-03" version="1">MKGSLIIGALCALGAVASPLNMRVLVTDIEVTVVTITVTETPGYTPAAATTTVPASTTSVAPTTVPVAGAANLNNEYPRPPLTSTSTSTTLVVPSSSSTTFVAPEPTTTVAAAPAPTPVEPSTTSTSTSASTSPSVAPSSAGSSYQSLILNSHNIHRSNHSAPALTWNETLAESALKLANTCDYHHDTSLGPAANYGQNIAFGIDSDKVDEIITNMMYNDEMMFYQDLYGQANPDMSKFEKWGHFSQIVWLDTTSVGCATVTCQPLAESHSSLALPFTVCNYYPAGNYGGEYADNVLQPKGNAMVVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJZ8</accession>
    <name>B8MJZ8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_042870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484768.1">
        <property type="nucleotide sequence ID" value="XM_002484723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJZ8"/>
    <dbReference type="STRING" id="441959.B8MJZ8"/>
    <dbReference type="GeneID" id="8104764"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_042870"/>
    <dbReference type="eggNOG" id="KOG3857">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007207_0_2_1"/>
    <dbReference type="InParanoid" id="B8MJZ8"/>
    <dbReference type="OMA" id="TLCNPEC"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="PhylomeDB" id="B8MJZ8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08192">
        <property type="entry name" value="MAR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF107">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06800)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="2">
        <location>
            <begin position="19"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED14815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="366" mass="39660" checksum="4481CF90A6D8F763" modified="2009-03-03" version="1">MSKQRIQQLPLDSHRGHDAIFNASYLGDIPSALQEWNSKRVLLVVSKALDTKTSIVSDLEARLTDSVKLEHLQKKTGVGSHSPYADIIDIANRVQTNNIDAVISLGSGSYSDACKIAVMLSATLQPGFTETDMENLIDQKHGLAGYEKLNVPTSLSAGEWNSYASGTNSRGKKQHFGHASGSPTLILCDPRVAATTPAHLWLASGVRAVDHCVEGLGNVKCHEEAFRHFENGLKCFGDRKELLEGISECQAGSRKALLPFIKWHVSFGASHAIGHQLGSVAGVQHGSHDQVLSIFNKTLNWHEQSASDAVAKFVKLLGLPTRLSEVGVTNDEQIRKIAEMALTDVLARDNGLPAYEGIVEILDSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKE0</accession>
    <name>B8MKE0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_047440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485248.1">
        <property type="nucleotide sequence ID" value="XM_002485203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKE0"/>
    <dbReference type="GeneID" id="8099294"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_047440"/>
    <dbReference type="eggNOG" id="KOG1121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_440177_0_0_1"/>
    <dbReference type="InParanoid" id="B8MKE0"/>
    <dbReference type="OrthoDB" id="2976890at2759"/>
    <dbReference type="PhylomeDB" id="B8MKE0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED15295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="70556" checksum="AB850DB19D721D27" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKH3</accession>
    <name>B8MKH3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoglycerate mutase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_047740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485281.1">
        <property type="nucleotide sequence ID" value="XM_002485236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKH3"/>
    <dbReference type="GeneID" id="8099324"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_047740"/>
    <dbReference type="eggNOG" id="KOG4754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1012588_0_0_1"/>
    <dbReference type="InParanoid" id="B8MKH3"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="PhylomeDB" id="B8MKH3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07040">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED15328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="31379" checksum="A37D62827DE2E7BB" modified="2009-03-03" version="1">MAITESMTTAKRNEESYLTYSAVKGYFLQDEEDTDASRFDYVAKNFGLINRKYDYEEGLSARHKGHEDAAEETKPMTQWAGFEQQVRTLNGEAGPNVQYKVLYLGRHGEGFHNVAQNWYGDEAWDCYWSMQDGNETSTWSDAKLTEVGKAQAQTAHDAWWKQIENEIPFPEIFYVSPLNRCLQTAFITFYGLEKDIVKPFTPTVKEEYTPATVARANQIFKENTQTTLSKRALLKKTSYGSLNTANQTLCVTHASRVSLMIYSPLIATMTNTLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKP1</accession>
    <name>B8MKP1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PQ loop repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_043610</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the laat-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484843.1">
        <property type="nucleotide sequence ID" value="XM_002484798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKP1"/>
    <dbReference type="STRING" id="441959.B8MKP1"/>
    <dbReference type="GeneID" id="8097869"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_043610"/>
    <dbReference type="eggNOG" id="KOG2913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019699_3_2_1"/>
    <dbReference type="InParanoid" id="B8MKP1"/>
    <dbReference type="OMA" id="NDRLEWI"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="PhylomeDB" id="B8MKP1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034488">
        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000009">
        <property type="entry name" value="PQ loop repeat family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF34">
        <property type="entry name" value="LYSOSOMAL AMINO ACID TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="205"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED14890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="430" mass="47467" checksum="C4BF8329709B5839" modified="2009-03-03" version="1">MSSPVLSPLHSLTGYSLPQHCEPSSNFLALLSSTLHICIPNELGLISSSLGCLSIVSWLFAQLPQIYKNYKLQSTAGLSAFFLVEWCLGDTANLVGALFTRQATWQVTIASYYVFVDVVLVIQYYWYTYVKKKGKGKDSVDGSFDEDNAPIYDGIRVRDENQPVDDVYSTKIMRPSEPKDVELFKSSANSPPRFYSPSYSEKFGNRRVRNTGYPSGTNASPTPSMATSPTHSPLPSNFDAITDSHDMDIETIGRILSWMSTILYLGSRLPQLYKNYVRKSTSGLSPLLFMAAFCGNFFYSASLLTNPNAWYDYPAYGGGGWADKDGNNRAEWVALATPFFLGAAGVLSLDAFMGVQFLIYGDQGGEPLVTVDDPTDPGHKRWRRVSGWMRGWIPSGELNKYLRSNSGSQLAETRSLLGDSNTSGHNYGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8ML47</accession>
    <name>B8ML47_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NACHT and TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_049030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485416.1">
        <property type="nucleotide sequence ID" value="XM_002485371.1"/>
    </dbReference>
    <dbReference type="GeneID" id="8100619"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_049030"/>
    <dbReference type="eggNOG" id="ENOG502SKQS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001466_4_0_1"/>
    <dbReference type="InParanoid" id="B8ML47"/>
    <dbReference type="OMA" id="STIESAW"/>
    <dbReference type="OrthoDB" id="448455at2759"/>
    <dbReference type="PhylomeDB" id="B8ML47"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031350">
        <property type="entry name" value="Goodbye_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17109">
        <property type="entry name" value="Goodbye"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="301"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="640"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="658"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="683"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED15463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1440" mass="163044" checksum="227DEF6B14766D8A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLL2</accession>
    <name>B8MLL2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EF-hand calcium-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_049830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485498.1">
        <property type="nucleotide sequence ID" value="XM_002485453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLL2"/>
    <dbReference type="GeneID" id="8108747"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_049830"/>
    <dbReference type="eggNOG" id="KOG2551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051938_4_1_1"/>
    <dbReference type="InParanoid" id="B8MLL2"/>
    <dbReference type="OMA" id="CRIAGTH"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="PhylomeDB" id="B8MLL2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF7">
        <property type="entry name" value="SERINE HYDROLASE FSH DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED15545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="253" mass="27851" checksum="0BC0CC9127CAF795" modified="2009-03-03" version="1">MKFLCLHGRGTNSDIFESQLVNLRSCLSSAHIFDFIDAQFDCPPAPGIGDFYPPPYLCWHERYEPKDVQAVHDYINSVIEEDGPYDGIIGFSEGAALAASLLLCEEYTRSGGAAASIKVAIFLNGVVALSPSEKIGYNIGEAIMADQDRYIGLLHGFESEDVDKSNDEKRFSHIYGFSPDDFPCRISIPTLHVIGEGDSFAKHARAIADLCQQEKAEVFLHDGGHELPRSEATIRRCADVFERVVTMASLDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLM3</accession>
    <name>B8MLM3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_049940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485509.1">
        <property type="nucleotide sequence ID" value="XM_002485464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLM3"/>
    <dbReference type="GeneID" id="8108758"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_049940"/>
    <dbReference type="HOGENOM" id="CLU_2160106_0_0_1"/>
    <dbReference type="InParanoid" id="B8MLM3"/>
    <dbReference type="OrthoDB" id="4357294at2759"/>
    <dbReference type="PhylomeDB" id="B8MLM3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="12415" checksum="0F2321FF0C720610" modified="2009-03-03" version="1">MADKPAVLPAHPRESRENAQTRIGAPMGRTKEQVAADFADFQRTIPSSDIVIFSDGSRLVDGCAGGGYIGLQAYHQFLRSSLSYGHGKEVFNTEAEAALAGAQAAIAYPTAQFATNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMN5</accession>
    <name>B8MMN5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_100340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486027.1">
        <property type="nucleotide sequence ID" value="XM_002485982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMN5"/>
    <dbReference type="STRING" id="441959.B8MMN5"/>
    <dbReference type="GeneID" id="8097918"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_100340"/>
    <dbReference type="eggNOG" id="ENOG502T05A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065174_0_0_1"/>
    <dbReference type="InParanoid" id="B8MMN5"/>
    <dbReference type="OMA" id="YIFSEVY"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="PhylomeDB" id="B8MMN5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="32659" checksum="785F1AC6B4845719" modified="2009-03-03" version="1">MSRLSSDFRLNSDILYSEFLSSDIITLATENSERTFKIHRALLESKTKGVFGRLDKFKEGTENIYRFQDTSDNTLLRFIEWAYRGDYPENIAKPSLASTNPTLASSSSDNDTTTAEDPLSCHIQVYIFAHVYGISRLGLVAYDRITDRLRAINKPKDGKVKLQVISLMDLAFKKIHRGDRLLTWLGNYASFCLSELRVVSEFQKVVEEAPSLSLAMLKYNNPASVAPWSPDPGPNSFSGFGSFSASNGLSSLSSSSASTTLLQNRNLFGRPVSPAPPAPPGSIFGPPAFGGSGPGLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8MN81</accession>
    <name>B8MN81_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_107370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486768.1">
        <property type="nucleotide sequence ID" value="XM_002486723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MN81"/>
    <dbReference type="GeneID" id="8106766"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_107370"/>
    <dbReference type="HOGENOM" id="CLU_1074329_0_0_1"/>
    <dbReference type="InParanoid" id="B8MN81"/>
    <dbReference type="PhylomeDB" id="B8MN81"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="259" mass="29498" checksum="B00F29EDAE0D6C91" modified="2009-03-03" version="1">MTLKSESTTSHQSEAESEPTGIPDDNFMAETRFNTVTRHKKINLTLWEKDAGPGDSVEALVNYIIRAMYKAALHNYFKEWTLVKFNKLDRTTRSKLKDFLQIDIPPRWPDDMIAGKKFNSRSRMALGQQAQLIPRSDTTPPAKRIKNYNRNHLIGLPYSNKEKEETTLRRDLERRINNNPLQLETHVRDLNSRTPLTGANAVPIGTPAPSPIKISTTPPPRPSTSLTSARQLDEYMRLPPTEYEQEDIDPSLAAKFSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNA8</accession>
    <name>B8MNA8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="2">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_102270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="2"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486235.1">
        <property type="nucleotide sequence ID" value="XM_002486190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNA8"/>
    <dbReference type="STRING" id="441959.B8MNA8"/>
    <dbReference type="GeneID" id="8099272"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_102270"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_4_1"/>
    <dbReference type="InParanoid" id="B8MNA8"/>
    <dbReference type="OMA" id="ETESIMW"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="PhylomeDB" id="B8MNA8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="13"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED13997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="163" mass="17924" checksum="0161E762301095A2" modified="2009-03-03" version="1">MDKYLALVNERTDKLQFDRVMGFIERGRVQGTLVTGGHRIGEKGYFIAPTVFTGVIKDSEINQQEIFGPIAIVNSFKTEEEAISLANDTAYGLMAGVLTQDINRALRISTELDTGMVGINAVSMAFRQAPFGGTKESGIGRESGVHALREYTEPKTLFVNLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNH3</accession>
    <name>B8MNH3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_102890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486300.1">
        <property type="nucleotide sequence ID" value="XM_002486255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNH3"/>
    <dbReference type="GeneID" id="8102908"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_102890"/>
    <dbReference type="HOGENOM" id="CLU_900730_0_0_1"/>
    <dbReference type="InParanoid" id="B8MNH3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="309" mass="36813" checksum="5814D6530633568F" modified="2009-03-03" version="1">MANQSAEDEAVRWIPVIVSVPTGLSIIIGTLKWIYKAQHDWAVSIYGLAVDKDKMDPLLPTMSKIIKLGEYEFNSSMFEWMSPVYTEISWVPLYEEVFRELEWNLEIRGHGEQFWEKCPCTYHRFLRFINDAWLHIKNILRRQPSRFPPVIRQALKDAKKDISKHIKEYHNWKLEQKPRREFLVEEWRQNEWLQGGLAQSEISQSELPQGEFEEDEWPRTRWLSVNWKGAPISWRPNNWSQSKELNYRHFHYPRILQNCVLRLDGPRCWEPFRPERLFKTHVQDLDLQTIVICDGVPAIPISSKELGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNI3</accession>
    <name>B8MNI3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-PSP endoribonuclease family protein Brt1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_102990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486310.1">
        <property type="nucleotide sequence ID" value="XM_002486265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNI3"/>
    <dbReference type="STRING" id="441959.B8MNI3"/>
    <dbReference type="GeneID" id="8102918"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_102990"/>
    <dbReference type="eggNOG" id="KOG2317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_7_2_1"/>
    <dbReference type="InParanoid" id="B8MNI3"/>
    <dbReference type="OMA" id="VKLNIFM"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="PhylomeDB" id="B8MNI3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF22">
        <property type="entry name" value="ENDORIBONUCLEASE FAMILY PROTEIN BRT1, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03780)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="128" mass="13804" checksum="F76875E6AE723C73" modified="2009-03-03" version="1">MATKTPVLTSKAPKPLPGIYSQAIIANGVVYCSGAVALDPETGKLIDGDVKAHTHQCIKNLTHVLEAAGTTIDKVVKVNVFLDNMDNFADMNEVYTQYWGDVKPCRTCVAVKTLPLNTDVEIECIAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNI6</accession>
    <name>B8MNI6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reverse transcriptase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_103020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486313.1">
        <property type="nucleotide sequence ID" value="XM_002486268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNI6"/>
    <dbReference type="STRING" id="441959.B8MNI6"/>
    <dbReference type="GeneID" id="8102921"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_103020"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_23_2_1"/>
    <dbReference type="InParanoid" id="B8MNI6"/>
    <dbReference type="OMA" id="HRAQNTI"/>
    <dbReference type="OrthoDB" id="4226558at2759"/>
    <dbReference type="PhylomeDB" id="B8MNI6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877605" evidence="1">
        <location>
            <begin position="25"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="405"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="3">
        <location>
            <begin position="877"/>
            <end position="1024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED14075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1193" mass="134580" checksum="541F86BBD6711916" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNJ7</accession>
    <name>B8MNJ7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_103130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-50 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486324.1">
        <property type="nucleotide sequence ID" value="XM_002486279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNJ7"/>
    <dbReference type="FunCoup" id="B8MNJ7">
        <property type="interactions" value="640"/>
    </dbReference>
    <dbReference type="GeneID" id="8103016"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_103130"/>
    <dbReference type="eggNOG" id="KOG3012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066239_1_2_1"/>
    <dbReference type="InParanoid" id="B8MNJ7"/>
    <dbReference type="OMA" id="YRNFMYR"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="PhylomeDB" id="B8MNJ7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007881">
        <property type="entry name" value="UNC-50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841:SF6">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05216">
        <property type="entry name" value="UNC-50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED14086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="292" mass="32814" checksum="76DCDA1CA28F6245" modified="2009-03-03" version="1">MNPHISVPRQHSIPSSFGGSSGAGSAGRGSSSIKMPRFFKRLFKFPQMDFEMAIWEMTSLLIAPKKVFKSMYYHKQTKNTWHRPDPSFTYLLSFFLLLTALAWGLAYSPSFGSIFRLSILFVFVHFIGTSLLISTIAYFAVGRIFGPKGAAASLTGLSRGSRMPRRGAAQGLFAQPGEKEQIEFGYCFDVSNRAFFPLYLHLYVLQFLLLPILTRNPPNFLTTFLGNTLYLSALLYYTYITFLGYNALPFLHNTELLLLPILVLSILWLVSLIAGWNVVTQGRGVEGLFWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPB3</accession>
    <name>B8MPB3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-protein thioesterase 1,2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_105630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486590.1">
        <property type="nucleotide sequence ID" value="XM_002486545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPB3"/>
    <dbReference type="STRING" id="441959.B8MPB3"/>
    <dbReference type="GeneID" id="8100422"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_105630"/>
    <dbReference type="eggNOG" id="KOG2112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049413_2_1_1"/>
    <dbReference type="InParanoid" id="B8MPB3"/>
    <dbReference type="OMA" id="PKSEHTH"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="PhylomeDB" id="B8MPB3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF63">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="3">
        <location>
            <begin position="67"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="3">
        <location>
            <begin position="265"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED14352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="338" mass="37359" checksum="6B707E109F3E147E" modified="2009-03-03" version="1">MQKQERKNPYPILLCVEPLRPQHTHTFIILHGRGSNAEKFGRELLASANLPARLPTVNLDDPNQRTDLQADGLMETAKFLRELVDAEARVLDNGAGETGYKRVIIGGLSQGCAAAIFTLLGGGFGKSGNERPGAFFGMSGWLPFEKQLNSMVSNERIHETEDEDEEEDDSESSDDDDRSESDVGINVSFSDAESDNFASDAEVNLASFDAFQLDPQDNPENNIADALNFVRDILDLPPVVIGPSAPDDDDNETNHKMTTKTFPILQTPIFLGHGLADPKVSVRLGEKMAEILSKKIKIDVTWKAYEGFGHWYKVPDEIDDILEFLQQNLGLPVEMLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQ17</accession>
    <name>B8MQ17_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_054190</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="4"/>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487018.1">
        <property type="nucleotide sequence ID" value="XM_002486973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQ17"/>
    <dbReference type="STRING" id="441959.B8MQ17"/>
    <dbReference type="GeneID" id="8100358"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_054190"/>
    <dbReference type="eggNOG" id="KOG2277">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002806_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQ17"/>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="PhylomeDB" id="B8MQ17"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF113">
        <property type="entry name" value="POLY(A) RNA POLYMERASE CID11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="10">
        <location>
            <begin position="113"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="9">
        <location>
            <begin position="334"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="437"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="570"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="610"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="758"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="892"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="441"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="636"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="686"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="785"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="821"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="925"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="939"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="977"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED12907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1073" mass="119322" checksum="AE91E0CF5C9FD7B4" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQ38</accession>
    <name>B8MQ38_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nonribosomal peptide synthase GliP-like, putative</fullName>
            <ecNumber evidence="6">6.3.2.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_055660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.26" evidence="6"/>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487175.1">
        <property type="nucleotide sequence ID" value="XM_002487130.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MQ38"/>
    <dbReference type="GeneID" id="8102259"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_055660"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_0_5_1"/>
    <dbReference type="InParanoid" id="B8MQ38"/>
    <dbReference type="OMA" id="CCIKEVF"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050564">
        <property type="term" value="F:N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF11">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="511"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1535"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="2072"/>
            <end position="2148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED13064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="2151" mass="239511" checksum="C1063A72EE1F64CE" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQH6</accession>
    <name>B8MQH6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable beta-glucosidase btgE</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Beta-D-glucoside glucohydrolase btgE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Cellobiase btgE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Gentiobiase btgE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSTA_058670</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487489.1">
        <property type="nucleotide sequence ID" value="XM_002487444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQH6"/>
    <dbReference type="STRING" id="441959.B8MQH6"/>
    <dbReference type="GeneID" id="8106469"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_058670"/>
    <dbReference type="eggNOG" id="ENOG502QS0R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027285_2_0_1"/>
    <dbReference type="InParanoid" id="B8MQH6"/>
    <dbReference type="OMA" id="VVCPYAT"/>
    <dbReference type="OrthoDB" id="4082933at2759"/>
    <dbReference type="PhylomeDB" id="B8MQH6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF24">
        <property type="entry name" value="FAMILY 17 GLUCOSIDASE SCW11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877919" description="Probable beta-glucosidase btgE" evidence="16">
        <location>
            <begin position="19"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="245"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="245"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EED13378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="587" mass="59790" checksum="B9BC055B21C7C5C8" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQI9</accession>
    <name>B8MQI9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BZIP transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_058790</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487502.1">
        <property type="nucleotide sequence ID" value="XM_002487457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQI9"/>
    <dbReference type="STRING" id="441959.B8MQI9"/>
    <dbReference type="GeneID" id="8106481"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_058790"/>
    <dbReference type="eggNOG" id="ENOG502QVAF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017851_2_0_1"/>
    <dbReference type="InParanoid" id="B8MQI9"/>
    <dbReference type="OMA" id="KKVHTEQ"/>
    <dbReference type="OrthoDB" id="644067at2759"/>
    <dbReference type="PhylomeDB" id="B8MQI9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416:SF8">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="263"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="254"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED13391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="644" mass="72289" checksum="904A028016B5838D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MR41</accession>
    <name>B8MR41_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NADH-ubiquinone oxidoreductase B12 subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_054480</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB3 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="NDUFB3"/>
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        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 3"/>
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    </dbReference>
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        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B12 SUBUNIT"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF08122">
        <property type="entry name" value="NDUF_B12"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="13" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED12936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="86" mass="9898" checksum="8542157103B31503" modified="2009-03-03" version="1">MSSRNPTGFDLKEFKAAAHPRSVWAKKDPWARHEAWRYTGPFSRWNRFKGLFPGLGTATVLFAGYLAYEQVFLSNDHGHGHEESHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MR75</accession>
    <name>B8MR75_TALSN</name>
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        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_054800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EED12970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002487036.1"/>
    </dbReference>
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    <dbReference type="STRING" id="441959.B8MR75"/>
    <dbReference type="GeneID" id="8100487"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_054800"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_3_1"/>
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    <dbReference type="OMA" id="YEETKFC"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="PhylomeDB" id="B8MR75"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF50">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="485"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="517"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="553"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED12970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="599" mass="67088" checksum="61248030AB6A8EB3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRC0</accession>
    <name>B8MRC0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1770 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_055200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487126.1">
        <property type="nucleotide sequence ID" value="XM_002487081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRC0"/>
    <dbReference type="STRING" id="441959.B8MRC0"/>
    <dbReference type="GeneID" id="8102213"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_055200"/>
    <dbReference type="eggNOG" id="ENOG502SAKD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101474_0_0_1"/>
    <dbReference type="InParanoid" id="B8MRC0"/>
    <dbReference type="OMA" id="GWRHWNR"/>
    <dbReference type="OrthoDB" id="2430343at2759"/>
    <dbReference type="PhylomeDB" id="B8MRC0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140580">
        <property type="term" value="F:mitochondrion autophagosome adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013898">
        <property type="entry name" value="Atg43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699:SF1">
        <property type="entry name" value="MITOPHAGY RECEPTOR ATG43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08589">
        <property type="entry name" value="ATG43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="20246" checksum="4B51850705D1841B" modified="2009-03-03" version="1">MSHAALGIAETIQTASIKRHPSPRHDINPSTAASEKLPYEDADHSDTASIATDILDRPAALRPAARRRDLPPLPDLRFEQSYLASIRGAETWQRVTWITIRDQVFLPLIQGTLWTLALCGWRFWNRNAQLHGNTLGTRLRRWWYGVNNWPIPPQGIKSNKKFAERVQDFYTAQFSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRW4</accession>
    <name>B8MRW4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_057870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487409.1">
        <property type="nucleotide sequence ID" value="XM_002487364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRW4"/>
    <dbReference type="STRING" id="441959.B8MRW4"/>
    <dbReference type="GeneID" id="8108923"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_057870"/>
    <dbReference type="eggNOG" id="ENOG502T5S7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1511590_0_0_1"/>
    <dbReference type="InParanoid" id="B8MRW4"/>
    <dbReference type="OrthoDB" id="3259102at2759"/>
    <dbReference type="PhylomeDB" id="B8MRW4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED13298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="178" mass="18960" checksum="5ED833FB6E69FEA3" modified="2009-03-03" version="1">MRRVASGGICGGWYACILDRKPNGAQIRVKIKGIDCSKITNDNKRSIEDEAFTPHTLLGRARSGAVLGNDSKVTFVDSDVYGNKTNGSVAMIIPFDVPDDIVGIFTVDYTIASGPLKSGSLVDDWGNGLGPVPISDSGQTTSATVEVGPDGVGNVMMFAWVDTFAVFHELLDKLLHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSR1</accession>
    <name>B8MSR1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Ubiquitin-related modifier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">URM1</name>
        <name evidence="7" type="ORF">TSTA_005560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of UBA4, then thiocarboxylated (-COSH) via the rhodanese domain of UBA4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the URM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488173.1">
        <property type="nucleotide sequence ID" value="XM_002488128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSR1"/>
    <dbReference type="FunCoup" id="B8MSR1">
        <property type="interactions" value="882"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MSR1"/>
    <dbReference type="GeneID" id="8105530"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_005560"/>
    <dbReference type="eggNOG" id="KOG4146">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148208_0_0_1"/>
    <dbReference type="InParanoid" id="B8MSR1"/>
    <dbReference type="OMA" id="DYELQPN"/>
    <dbReference type="OrthoDB" id="10248987at2759"/>
    <dbReference type="PhylomeDB" id="B8MSR1"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01764">
        <property type="entry name" value="Ubl_Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03048">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015221">
        <property type="entry name" value="Urm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14986">
        <property type="entry name" value="RURM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09138">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037379">
        <property type="entry name" value="Ubiquitin-related_modifier_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="modified residue" description="1-thioglycine" evidence="5">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)" evidence="5">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED12519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="117" mass="13207" checksum="F5D7EE9F3B9FED38" modified="2009-03-03" version="1">MVSNPDTENPSQPDETISISVEFTGGLEMLFANERKHNLTIPAKTNDGKQPTIGWLIQYLVENLMQDTRKELFILDDHVRPGILVLINDADWELEGEEAYDIQPKDNILFVSTLHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSR7</accession>
    <name>B8MSR7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_006250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488253.1">
        <property type="nucleotide sequence ID" value="XM_002488208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSR7"/>
    <dbReference type="STRING" id="441959.B8MSR7"/>
    <dbReference type="GeneID" id="8105310"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_006250"/>
    <dbReference type="eggNOG" id="ENOG502RNRR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_577685_0_0_1"/>
    <dbReference type="InParanoid" id="B8MSR7"/>
    <dbReference type="OMA" id="YAGHEHI"/>
    <dbReference type="OrthoDB" id="5308957at2759"/>
    <dbReference type="PhylomeDB" id="B8MSR7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="7"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED12599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="487" mass="54771" checksum="3CEC0CEE8A2C5562" modified="2009-03-03" version="1">MKTSIPSDVWEKKKALIARLYKDEEWPLKQVIKQIRTEDFNPSETQLRSRLKKWRVTKPSRQIRKKPAGEQGNNNDEEDEEDPSEEMSPMERRNNKSDMKKNTPTTSAAMAIPTPPQSQHSQSDNLAITREWYPTDVWVQSQQEQQHIPPQQTVVVTQPEAVATQAWTASIPSPSPITATTPERHPSHGAVSTPAVTQYATHGLSAYDLPHPQPQQPSPTNSIPPPQTTHVLSPAYVSPISPTYAMAPISYPQPAPPTATHWPTGNDYIEPDSNPAAAMTMQPSSWYTAMYDAANTTAVTANAAYYQRAVNPAAPVAGYNPVMQHMPSPQEMATSYQVQAHAHAQAQARPMTAPGYHGYDEGVSVRPWRRATASHYTPEYVPGVVRVDRQGRQRKPLPDRKKESVTEQMDIMAAQQQQQQKQQHQQRELEHLQSMQQSMHTAIQPVYQHPHHPQQHPHYIAAGHSMIPQDMYAYAGHEHILQRPMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSZ2</accession>
    <name>B8MSZ2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7881 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_002150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487802.1">
        <property type="nucleotide sequence ID" value="XM_002487757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSZ2"/>
    <dbReference type="STRING" id="441959.B8MSZ2"/>
    <dbReference type="GeneID" id="8102826"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_002150"/>
    <dbReference type="eggNOG" id="ENOG502SKV9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055165_2_0_1"/>
    <dbReference type="InParanoid" id="B8MSZ2"/>
    <dbReference type="OMA" id="PEPYGKQ"/>
    <dbReference type="OrthoDB" id="2142759at2759"/>
    <dbReference type="PhylomeDB" id="B8MSZ2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057203">
        <property type="entry name" value="DUF7881"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25324">
        <property type="entry name" value="DUF7881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7881" evidence="1">
        <location>
            <begin position="9"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="266" mass="30697" checksum="DDA01F0169FBEDE8" modified="2009-03-03" version="1">MPIDRSRVRNVFIYDGATRDCFGGMRQNGSITEAVFLWILNYILILTDDECQVKARASQQIILPTSNPLEPGDYDVYCNGRWYDLKSTIELTNEPWVQRILSHSVSGREDSFRDGLRTRDGRCVLSGFPNLNADIGDWSPFEGAHIFPLEKEAIWITYNFGRWITDMDYTNGVIFIRLFNRDIFGLDGRVLDPVCRIPADPHRVSDELLRWHFRQSVLANMRGAGEPIFEHDFPPGTDMIKEIREGPSAQERFEMEIASRLRAFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MT31</accession>
    <name>B8MT31_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_001790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487765.1">
        <property type="nucleotide sequence ID" value="XM_002487720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MT31"/>
    <dbReference type="GeneID" id="8098673"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_001790"/>
    <dbReference type="eggNOG" id="ENOG502SC56">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_30_1_1"/>
    <dbReference type="InParanoid" id="B8MT31"/>
    <dbReference type="OMA" id="HINRADA"/>
    <dbReference type="OrthoDB" id="4226558at2759"/>
    <dbReference type="PhylomeDB" id="B8MT31"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF25">
        <property type="entry name" value="RNASE H TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="66"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED12111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="395" mass="44792" checksum="A1824D70CF153D93" modified="2009-03-03" version="1">MVGLFQANPPTVTTHTPINRKLGRDTSQRIETIYPFVVPPWWEPPEARIDDTREEAIKAIEAISGTDTTIQFFTDWSGFDNGIGAAVYSSIGQAYKPVGSSDTHTVYAGELEGIDAALEILLRSQPCDDNPHEATIYTDNQAAIRATCQPGRSSGQYILRRIVRHLGLLRDNRSRWRVRLQWVPGHEGVPGNEKADQLAKLAAVEATRRTQENARIARISAPNQTTPHAARMSYIPNQSTILMAVCRQRLHAGFAKRWKEQWEHANHGRHLYRIIKAPTKMVLQLHEGLRRAWSSVLIQLQTGKSALRSFLASVRIEDSPQCECGLGDQDTAHVLIRCPTHINLRMETLWKEARETDYRKLLSEPQWVRQSIEFMMRTGLLTQFHHVTPLTTTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MT61</accession>
    <name>B8MT61_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_003250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487917.1">
        <property type="nucleotide sequence ID" value="XM_002487872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MT61"/>
    <dbReference type="FunCoup" id="B8MT61">
        <property type="interactions" value="532"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MT61"/>
    <dbReference type="GeneID" id="8098021"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_003250"/>
    <dbReference type="eggNOG" id="KOG3386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8MT61"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="PhylomeDB" id="B8MT61"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF115">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED12263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="187" mass="20739" checksum="E0AE845F20603842" modified="2009-03-03" version="1">MDHSHMDHGDMDMGHGGGKCVTNMLFTWSTHNMCIIFPEWRVQGTGSLLASLFAIILLTAGYEAVRNFTRLYEASHTQRLKAFSSSVLADTETTSGDNSPEEDTRREGLARFTNSLLVGRDSKQVLERRGRLIMATLYAVQVFYSFFIMLLFMTYNGWVMISVAVGAFVGYLVFGGDAPATKSAACH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTC0</accession>
    <name>B8MTC0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SH3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_004190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488024.1">
        <property type="nucleotide sequence ID" value="XM_002487979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTC0"/>
    <dbReference type="FunCoup" id="B8MTC0">
        <property type="interactions" value="126"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MTC0"/>
    <dbReference type="GeneID" id="8100130"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_004190"/>
    <dbReference type="eggNOG" id="KOG3601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064525_1_1_1"/>
    <dbReference type="InParanoid" id="B8MTC0"/>
    <dbReference type="OMA" id="EWWKGRN"/>
    <dbReference type="OrthoDB" id="6250593at2759"/>
    <dbReference type="PhylomeDB" id="B8MTC0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF7">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="110"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED12370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="242" mass="25910" checksum="DAE03043976CF7AA" modified="2009-03-03" version="1">MASQGEFSAAMTNRSLRTIRTELEFLTDASVITPQQLANLLSQLPNQTVLHAPVMSASGPIPAPVQSPDPTPAFNPPTAQLQNTSLNEKAPISQYPSPAPPPPAYAQGPPVLSISSAMYAYTPTDAGDLALQPNDRIQVLEHMNNDWWRGRNERTNQEGIFPRSYVRVLDEKPAPPVLSPQPTNYGNMPLEVAQSGSPATDASGHRPSKFEEQGKKFGKKIGNAAIFGAGATIGSNIVNGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUX8</accession>
    <name>B8MUX8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_109250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488502.1">
        <property type="nucleotide sequence ID" value="XM_002488457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUX8"/>
    <dbReference type="STRING" id="441959.B8MUX8"/>
    <dbReference type="GeneID" id="8107157"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109250"/>
    <dbReference type="eggNOG" id="ENOG502SKFN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028906_4_1_1"/>
    <dbReference type="InParanoid" id="B8MUX8"/>
    <dbReference type="OMA" id="MRPSNML"/>
    <dbReference type="OrthoDB" id="5412996at2759"/>
    <dbReference type="PhylomeDB" id="B8MUX8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="68"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="467" mass="54059" checksum="D956F429575021AE" modified="2009-03-03" version="1">MPQQKTSSLKTYLDEIEETNGDDECKAWLKRVFDLKVELANFVATRRAGEGSGKYIGFLKGSFNFSFRFSFDDGGPDAIIRFPKPGHTATAYRDEKVTNEVQIMEYLRQNTNIPIPRVHSWGLSAESPQLGPFIIMDYIEGVLLSTILKQPDQEDVILNPDIDNTILDKIYRQIAHYMLQLSQLTFPRIGAISKDHDSDTWYVAGRPLTYNMNELATVSGYLDNKFPITPFDRASDYLRSIANEHITHLWTQRNLADNAEIAQKRFIARHRFTQLIQKYYVEDSGPFIPFSDDMRPSNMLVNPETLSITAVLDLKFTNAMPAEFTYDPPWWLLLSGPEMWLERCAKDEFLTLYEPRLTQFLRALEQVEDETALECKQSSGPPLSTRMRDSWRTGRFWFDYAARKSFDVDIIYWAALHDGSMGAESLDDKTRAEVELFAQAKMEQLKAYKEEYERLDVRRGVWRIFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MVF2</accession>
    <name>B8MVF2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyketide synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_007510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962663">
        <property type="protein sequence ID" value="EED11461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488777.1">
        <property type="nucleotide sequence ID" value="XM_002488732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MVF2"/>
    <dbReference type="STRING" id="441959.B8MVF2"/>
    <dbReference type="GeneID" id="8103280"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_007510"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_619906_0_0_1"/>
    <dbReference type="InParanoid" id="B8MVF2"/>
    <dbReference type="OrthoDB" id="3799328at2759"/>
    <dbReference type="PhylomeDB" id="B8MVF2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF50">
        <property type="entry name" value="HIGHLY REDUCING POLYKETIDE SYNTHASE SRDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="2">
        <location>
            <begin position="36"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED11461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="442" mass="48962" checksum="E3D45D373E6D3D32" modified="2009-03-03" version="1">MLGKHLLPCLVKHQPVSTLPLTLLQLFDRDPLKRHLQWHTMGSQLVKYCVFQAAIRFLDCALAPLSTQDFCQTAEISQTVCTAIQIGLVDLLASWSIRPSGVVEHSSGEMAAAYAAGCITAAEAITIAYFRGQAVGKNKKKGAMLAVGLGINEICNYLKLEHFEDKVVVAAINSPENITLSGEVETITESMTILTKDGIFNRLLNTGGNAYHSHHMIALGSTYINILANGLTHMMQLGLSDNKKRYARIPWVSSVTPDKGLSGFDVTTGYWKANLESPVCFSEAVSILVGSEHNTVDVLIEIGPHGALKTPLNRILTSLGQSILYAPSLIKNEDSRVSILRLAGTLFCRNAKVDLVSVNAVDQPLVTGLQVVHGCTTIDLPPYQYTYGPISYTNKSKEQNTIEWSLTIYHFKIHLYRWKEMRRYLERWIKQSSPYQTADYMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>H9CNL6</accession>
    <name>H9CNL6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Intron-encoded GIY-YIG endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_m0060</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="2"/>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="BMC Genomics" volume="13" first="698" last="698">
            <title>Sequencing of mitochondrial genomes of nine Aspergillus and Penicillium species identifies mobile introns and accessory genes as main sources of genome size variability.</title>
            <authorList>
                <person name="Joardar V."/>
                <person name="Abrams N.F."/>
                <person name="Hostetler J."/>
                <person name="Paukstelis P.J."/>
                <person name="Pakala S."/>
                <person name="Pakala S.B."/>
                <person name="Zafar N."/>
                <person name="Abolude O.O."/>
                <person name="Payne G."/>
                <person name="Andrianopoulos A."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="23234273"/>
            <dbReference type="DOI" id="10.1186/1471-2164-13-698"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JQ354994">
        <property type="protein sequence ID" value="AFD95910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9CNL6"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_m0060"/>
    <dbReference type="InParanoid" id="H9CNL6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="11"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFD95910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="49" mass="5644" checksum="75AF958FEF032696" modified="2012-05-16" version="1">MLLNLLVIKKNKGGIYSFVNTVNGNQYIGSVKDLYIRLLEHIRNKKNPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8LT41</accession>
    <name>B8LT41_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vacuolar transporter chaperone complex subunit 4</fullName>
            <ecNumber evidence="3">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Polyphosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">SPX-dependent polyphosphate polymerase VTC subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Vacuolar membrane polyphosphate polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSTA_069670</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19574"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the VTC4 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="3"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340936.1">
        <property type="nucleotide sequence ID" value="XM_002340895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LT41"/>
    <dbReference type="FunCoup" id="B8LT41">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LT41"/>
    <dbReference type="GeneID" id="8101177"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_069670"/>
    <dbReference type="eggNOG" id="KOG1161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009308_0_0_1"/>
    <dbReference type="InParanoid" id="B8LT41"/>
    <dbReference type="OMA" id="NVNAYMR"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="PhylomeDB" id="B8LT41"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016237">
        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07751">
        <property type="entry name" value="PolyPPase_VTC4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.100.30:FF:000001">
        <property type="entry name" value="Vacuolar transporter chaperone 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
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    <sequence length="823" mass="94818" checksum="7629E16A81D0CD58" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8LU84</accession>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="137" mass="14733" checksum="7055B5AB2F9A6CB0" modified="2009-03-03" version="1">MSQYTTKQPISSSALNVRCINISPGTVSARSAAQNVHIKDPAKRLNTKHFAYARECPIQATCLAEAHQRRTYSPQYHTPVIRPGNIQPGAISPNDPTPAEAANTERSPRAPARIATTRQSANSSSKSAAAAQKRVAE</sequence>
</entry>
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    <accession>B8LUM3</accession>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <subcellularLocation>
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    <dbReference type="eggNOG" id="KOG0758">
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="18"/>
            <end position="101"/>
        </location>
    </feature>
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        <location>
            <begin position="116"/>
            <end position="205"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED23880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="307" mass="33826" checksum="70B823B835EC0FDB" modified="2009-03-03" version="1">MALEEFDKVEQELSQGWVRTAKDLFAGASGGITQVLLGQPFDIVKVRLQTTSQYSSALDCAKQIFKNEGPLAFYKGTLTPLIGIGACVSVQFGAFHQARRYFEEENLKKSPLSPGLSYTQYYLAGAFAGVTNSVISGPIEHVRIRLQAQPHGAGRLYNGPMDCVRKLSAHNGVLRGLYRGEVVTILREAQAYGMWFLAFEYLMNQDAKRNNIKREDISSLKVATYGGLAGEALWIFSYPFDVVKSKMQTDGFGTEQKYKSMTDCFKKTLAAEGYAGFWKGLGPTLLRAMPVSAGTFATVELVMRAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUM9</accession>
    <name>B8LUM9_TALSN</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002341232.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="B8LUM9">
        <property type="interactions" value="84"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LUM9"/>
    <dbReference type="GeneID" id="8099967"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_072760"/>
    <dbReference type="eggNOG" id="ENOG502SH72">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062645_0_1_1"/>
    <dbReference type="InParanoid" id="B8LUM9"/>
    <dbReference type="OMA" id="REFWPLF"/>
    <dbReference type="OrthoDB" id="2107885at2759"/>
    <dbReference type="PhylomeDB" id="B8LUM9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005619">
        <property type="term" value="C:ascospore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059112">
        <property type="entry name" value="CysZ/EI24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OUTER SPORE WALL PROTEIN RRT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07264">
        <property type="entry name" value="EI24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED23886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="267" mass="30504" checksum="98237FC38786BAEC" modified="2009-03-03" version="1">MLGSPKLRNATWLHPLRGIAYFISHPFLWPLLRSRLLPIFLLSGFIYTLLFFFAYLPQVAFLAIFQGHSAWVNGAFLVLGEGAAIVALLFEAFFVDETLVDVFDAVLINEGFEQLVNKERVIHPDGVTPVKKLGKPTTSAVYAPFSFRQIVEFIFLLPLNFVPVAGVPMFLVLAGYRAGPFHHWRYFQLLEFTKDKRKRFIRSRQLKYTAFGTVALILQLIPMFSMLFLLTSAAGSALWAAEMEKHEAFLEAHRPEREEHLYHDDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUW2</accession>
    <name>B8LUW2_TALSN</name>
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        <submittedName>
            <fullName evidence="8">C2H2 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_074340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341441.1">
        <property type="nucleotide sequence ID" value="XM_002341400.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341443.1">
        <property type="nucleotide sequence ID" value="XM_002341402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUW2"/>
    <dbReference type="STRING" id="441959.B8LUW2"/>
    <dbReference type="GeneID" id="8106600"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_074340"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035240_1_0_1"/>
    <dbReference type="InParanoid" id="B8LUW2"/>
    <dbReference type="OMA" id="FHMLGMC"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001704">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zinc finger protein Gfi-1b isoform X1"/>
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    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="469"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="498"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="275"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED24054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="546" mass="61194" checksum="CA84BF2E79B2E455" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVK0</accession>
    <name>B8LVK0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome c oxidase assembly protein Cox19, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_074040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the assembly of mitochondrial cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the COX19 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341406.1">
        <property type="nucleotide sequence ID" value="XM_002341365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVK0"/>
    <dbReference type="FunCoup" id="B8LVK0">
        <property type="interactions" value="308"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LVK0"/>
    <dbReference type="GeneID" id="8107643"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_074040"/>
    <dbReference type="eggNOG" id="KOG3477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141947_3_1_1"/>
    <dbReference type="InParanoid" id="B8LVK0"/>
    <dbReference type="OMA" id="GTNDEAC"/>
    <dbReference type="OrthoDB" id="268594at2759"/>
    <dbReference type="PhylomeDB" id="B8LVK0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051383">
        <property type="entry name" value="COX19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED24019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="96" mass="10510" checksum="07AC897ACC93CA2F" modified="2009-03-03" version="1">MSFGAPGGAAANFKPTPPERGSFPLDHDGECKHLIQNYLKCLKSQGGVNNEDCRKLAKGYLGCRMDKNLMAPDEFENLGLEFKEKSTGDDTTVKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVQ3</accession>
    <name>B8LVQ3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_075550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341570.1">
        <property type="nucleotide sequence ID" value="XM_002341529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVQ3"/>
    <dbReference type="STRING" id="441959.B8LVQ3"/>
    <dbReference type="GeneID" id="8099994"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_075550"/>
    <dbReference type="eggNOG" id="KOG0221">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1797744_0_0_1"/>
    <dbReference type="InParanoid" id="B8LVQ3"/>
    <dbReference type="OrthoDB" id="29596at2759"/>
    <dbReference type="PhylomeDB" id="B8LVQ3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED24183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="144" mass="16317" checksum="2EA498CBE107BC48" modified="2009-03-03" version="1">MASLKSKRESAPRNSFRASSAQRRVATDPVNPVRLRPLSLGASVITTNNIEESQDQQRRVIKQGAECDLDLFKGRMLYLKQDAIDIASIIPEEPQIEVNVIYFCQLGFNIPIPFDNIGRVTYTGSGGTWEQVFKDERMRELDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVW3</accession>
    <name>B8LVW3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_076960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341716.1">
        <property type="nucleotide sequence ID" value="XM_002341675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVW3"/>
    <dbReference type="GeneID" id="8102014"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_076960"/>
    <dbReference type="eggNOG" id="ENOG502SM8K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034380_0_0_1"/>
    <dbReference type="InParanoid" id="B8LVW3"/>
    <dbReference type="OMA" id="TDSWNTD"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="PhylomeDB" id="B8LVW3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED24329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="412" mass="46259" checksum="6F463C9ADE8FAAAC" modified="2009-03-03" version="1">MWLARGVQSAIFYYATCTPCAAAEDRRRRKKEAIRTQREQAKSAVIVTDQPRLFPQPTPFSTNVGWMEEIALGPGPPARRHRARNCQNDGLPRLSSTSSMTVEGSVLSGGREKVTSLSEKLHWSRFQREDEILWGEEEDNTVQGSSVGISGRARAGTGHSNKYYIARAPPVNDLHPPIVSGPTSRAETRWMLQPPPSAKVMAGKARHDVSRESRGSSIRRRSRIDMKIKESDEEEEMIQEGQLSSITDRPDWLIRKATNSYRRTGDKKSRPTMLEIDTKLSPGKVDGNYGSLQPPPTAATTETGRSTSMTNVRAYDEWHLQLSPSFDSRSSSPSSMGSPDDSLHWPDTPYSRPDSKRTATDPGKVFHPSYLNLAASANRDENKSIEAIHLEVNEPRSREQMQPLKWRWSFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVW6</accession>
    <name>B8LVW6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_077000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341719.1">
        <property type="nucleotide sequence ID" value="XM_002341678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVW6"/>
    <dbReference type="GeneID" id="8104695"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_077000"/>
    <dbReference type="eggNOG" id="ENOG502RZ72">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035633_0_0_1"/>
    <dbReference type="InParanoid" id="B8LVW6"/>
    <dbReference type="OMA" id="AWGFEDP"/>
    <dbReference type="OrthoDB" id="5360701at2759"/>
    <dbReference type="PhylomeDB" id="B8LVW6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED24332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="250" mass="27902" checksum="CF3D1399BCD92285" modified="2009-03-03" version="1">MPRPENPEYPRRDEKVFISPEVLELYTKIHVLLKRADYLPQVFSLYANKPIPEPNTSPIQFRQQNPKSVKNAISSKLANEALEIALEQKNLSLALAIIDTTFCAPAFTRAKLLKNAAVPLAGLATAPLASYVVATWAASMQNTMDPSMATGITFTATLAYIGFTSSVGVIAIATSNDQMERVSWAPGIPLRNRWLREEERGALDRVAVAWGFKDPYRRGEEEGEEWESLREFIGIRGMVLDKTELMEGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWJ2</accession>
    <name>B8LWJ2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_076690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341690.1">
        <property type="nucleotide sequence ID" value="XM_002341649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWJ2"/>
    <dbReference type="GeneID" id="8105628"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_076690"/>
    <dbReference type="HOGENOM" id="CLU_2980681_0_0_1"/>
    <dbReference type="InParanoid" id="B8LWJ2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED24303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="58" mass="6592" checksum="08F0729AA6C95FA1" modified="2009-03-03" version="1">MLEKSLCPDTEDCFYRADHEKDSKLRDKLAQDFGATMRGDGSCRIDEHVPVPGHSRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWQ5</accession>
    <name>B8LWQ5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTPase-activating protein GYP5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_078150</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GYP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341839.1">
        <property type="nucleotide sequence ID" value="XM_002341798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWQ5"/>
    <dbReference type="STRING" id="441959.B8LWQ5"/>
    <dbReference type="GeneID" id="8109441"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_078150"/>
    <dbReference type="eggNOG" id="KOG1102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008177_0_0_1"/>
    <dbReference type="InParanoid" id="B8LWQ5"/>
    <dbReference type="OMA" id="HDMPGLH"/>
    <dbReference type="OrthoDB" id="295078at2759"/>
    <dbReference type="PhylomeDB" id="B8LWQ5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000044">
        <property type="entry name" value="GTPase-activating protein GYP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="12">
        <location>
            <begin position="375"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="25"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="275"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="410"/>
            <end position="475"/>
        </location>
    </feature>
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        <location>
            <begin position="740"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00072088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED24452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="876" mass="96490" checksum="3BD1FD28789CE716" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B8LX01</accession>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_079890"/>
    <dbReference type="HOGENOM" id="CLU_2147545_0_0_1"/>
    <dbReference type="InParanoid" id="B8LX01"/>
    <dbReference type="PhylomeDB" id="B8LX01"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED24634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="100" mass="11149" checksum="FB961A5A2BE2610A" modified="2009-03-03" version="1">MLRMLKFAFGAMPGLFGGSVSVLTKILEFLTFVKDILDVVKDIVAIVKELKGQPRWGHQISTLSAIPYLSQPIYQLFLGFFKALPSAESSFVSVFILFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B8LX12</accession>
    <name>B8LX12_TALSN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_080000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Trichocomaceae</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
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    <dbReference type="InParanoid" id="B8LX12"/>
    <dbReference type="OrthoDB" id="3919880at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="EED24645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="279" mass="31908" checksum="FDB484F388632AC1" modified="2009-03-03" version="1">MFNVSNRPVVTEIDEARGVGLNTHAYGSPTTTARVNKDMKWAYMDGLSDAEREHRNKKDTWEYMPRLSNVQREKSILEFLRSAHHWSIKDFIQQLAHPEKVPYAHGAQVRIYQLRQAIIEQPEVLKIFMEDKQLIPSMLVEGVSAIVREELYTLMQEVPLLSKFHVDSSPKDLNVKDFYKEVGGKAPILWRLLQTISAQLEDDTVSNQQNGSFGLIAALLSHALAPRLSSGFQAYIGLYFHSLGARRRLIDLLHSLNISLSYDSILRYHNEIAKIAQVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8LX81</accession>
    <name>B8LX81_TALSN</name>
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        <recommendedName>
            <fullName evidence="5">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <lineage>
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            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002340077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LX81"/>
    <dbReference type="STRING" id="441959.B8LX81"/>
    <dbReference type="GeneID" id="8103956"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_062190"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_417475_0_0_1"/>
    <dbReference type="InParanoid" id="B8LX81"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="PhylomeDB" id="B8LX81"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
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        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF26">
        <property type="entry name" value="FAD-BINDING 8 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
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        <location>
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            <end position="47"/>
        </location>
    </feature>
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        <location>
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        <location>
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            <end position="144"/>
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        <location>
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            <end position="177"/>
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        </location>
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        <location>
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            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED22731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="657" mass="75294" checksum="DB8ADAB36017029B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8LX95</accession>
    <name>B8LX95_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_066270</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340563.1">
        <property type="nucleotide sequence ID" value="XM_002340522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LX95"/>
    <dbReference type="STRING" id="441959.B8LX95"/>
    <dbReference type="GeneID" id="8101020"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_066270"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010365_8_1_1"/>
    <dbReference type="InParanoid" id="B8LX95"/>
    <dbReference type="OMA" id="FPDYDSI"/>
    <dbReference type="OrthoDB" id="4216461at2759"/>
    <dbReference type="PhylomeDB" id="B8LX95"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF26">
        <property type="entry name" value="FAD-BINDING 8 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
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    </dbReference>
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        <property type="entry name" value="FAD_FR"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="244"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED23176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="506" mass="56892" checksum="C4B71FF1B216BCFA" modified="2009-03-03" version="1">MDIISIYAITAGGVFVALFLISILPYLCQLTKSLEVYISRYLIFPLFLRRHRFVGPWTRGAVLIHLLYTGVNLFCLCFGVSSPTEFADRSGTLAVVNMVASYTAGHVSFYSDILSISRHTCLQIHRATAWMVSGLLVLHVVLISTIQRGLSLDRTSNLFALIGAGCVVGLAVFALPYIHRHIFEVFLRTHQVLAYFLLYATWRHVGSDNRLSRICIITTFVLLSMALLLQLGFLIYRNKIFSLHGWPRARVSCNRPKIEGKDDSDVIIQVRVALTRPARIEAGQYINLWMPSVTWWSWAQVHPFMVTSWSHSAQEALDILIQPRHGFSRELLKHARAAPQGSASLRALIIGPHGMSENVDRYESVVLVASGFGIAAAIPYLKKLVYSYNTSASRTRRVHLVWEVETLDIAIAVQATLNSLLEDDVLKKRYILTISIYVKSGQIIGDVMKFGNHDRAVVYNGNANYDQILQAEMSGELIERLPNANEEKGESVVMGKRRPREPIYVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXF8</accession>
    <name>B8LXF8_TALSN</name>
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        <recommendedName>
            <fullName evidence="2">YMC020W-like alpha/beta hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_066840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED23239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002340585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXF8"/>
    <dbReference type="GeneID" id="8101051"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_066840"/>
    <dbReference type="eggNOG" id="ENOG502QR2T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010834_0_1_1"/>
    <dbReference type="InParanoid" id="B8LXF8"/>
    <dbReference type="OrthoDB" id="5598028at2759"/>
    <dbReference type="PhylomeDB" id="B8LXF8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058934">
        <property type="entry name" value="YMC020W-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058933">
        <property type="entry name" value="YMC020W-like_ab_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349:SF1">
        <property type="entry name" value="AER328WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26147">
        <property type="entry name" value="AB_HYDROLASE_YMC0-YMC35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="466"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="414"/>
        </location>
    </feature>
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        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
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        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
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        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED23239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="859" mass="94208" checksum="A9B21D2C089846C6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYC6</accession>
    <name>B8LYC6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_063360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340242.1">
        <property type="nucleotide sequence ID" value="XM_002340201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYC6"/>
    <dbReference type="STRING" id="441959.B8LYC6"/>
    <dbReference type="GeneID" id="8101173"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_063360"/>
    <dbReference type="HOGENOM" id="CLU_1876816_0_0_1"/>
    <dbReference type="InParanoid" id="B8LYC6"/>
    <dbReference type="OrthoDB" id="3598281at2759"/>
    <dbReference type="PhylomeDB" id="B8LYC6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED22855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="136" mass="15456" checksum="D34BAB51D07542FB" modified="2009-03-03" version="1">MKYTSKTTGKELNVFCISNKTYKKFSDQGNAGMVCTSGIPELRRFCLSMAAEPRLLEAKDFLQSKLPSLLNSITFWTKSAPTPKSDHTPSVSQFFQDVKAKFLTRTDNKKLRADWINAAIIKAQDWVKEKSERSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZ86</accession>
    <name>B8LZ86_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_083620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478093.1">
        <property type="nucleotide sequence ID" value="XM_002478048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZ86"/>
    <dbReference type="GeneID" id="8103325"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_083620"/>
    <dbReference type="HOGENOM" id="CLU_2122720_0_0_1"/>
    <dbReference type="InParanoid" id="B8LZ86"/>
    <dbReference type="OrthoDB" id="4206436at2759"/>
    <dbReference type="PhylomeDB" id="B8LZ86"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED21130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="114" mass="12881" checksum="2D9C8D7A299D4AF6" modified="2009-03-03" version="1">MRISKAYELTVNDLLLVRKENHDLRAAHEKEKEKRQISKKQISTKQVITREEAQALVQSQAEASQAVTTTPGEPELPASQPVKSRFGINIVYGFGKRWRLACDGGSLVDYVNWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8M067</accession>
    <name>B8M067_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aminotransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_083960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
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        <property type="entry name" value="PRK07483.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMINOTRANSFERASE"/>
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    </dbReference>
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        <property type="entry name" value="AMINOTRANSFERASE CLASS-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED21164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="962" mass="106616" checksum="5CF1CCDB2CC52017" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8M069</accession>
    <name>B8M069_TALSN</name>
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        <submittedName>
            <fullName evidence="2">RanGTP-binding protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_083980"/>
    <dbReference type="eggNOG" id="ENOG502R7I3">
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    <dbReference type="HOGENOM" id="CLU_014536_1_0_1"/>
    <dbReference type="InParanoid" id="B8M069"/>
    <dbReference type="OMA" id="WDPYNES"/>
    <dbReference type="OrthoDB" id="512915at2759"/>
    <dbReference type="PhylomeDB" id="B8M069"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008812">
        <property type="entry name" value="Ran_GTP-bd-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31010:SF2">
        <property type="entry name" value="RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31010">
        <property type="entry name" value="RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN 30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05508">
        <property type="entry name" value="Ran-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="379"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="680" mass="75957" checksum="53E0CCBBF3D0C7CA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8M104</accession>
    <name>B8M104_TALSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">TSTA_090230</name>
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    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    <dbReference type="AlphaFoldDB" id="B8M104"/>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_090230"/>
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    <dbReference type="HOGENOM" id="CLU_027731_1_0_1"/>
    <dbReference type="InParanoid" id="B8M104"/>
    <dbReference type="OMA" id="KFMERWG"/>
    <dbReference type="OrthoDB" id="5314201at2759"/>
    <dbReference type="PhylomeDB" id="B8M104"/>
    <dbReference type="Proteomes" id="UP000001745">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="516" mass="58750" checksum="EBCC557CF45B3A75" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8M144</accession>
    <name>B8M144_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NRPS-like enzyme, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_082190</name>
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    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477949.1">
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    <dbReference type="AlphaFoldDB" id="B8M144"/>
    <dbReference type="STRING" id="441959.B8M144"/>
    <dbReference type="GeneID" id="8107677"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_082190"/>
    <dbReference type="eggNOG" id="KOG1178">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002220_0_0_1"/>
    <dbReference type="InParanoid" id="B8M144"/>
    <dbReference type="OMA" id="KPGLWKF"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="PhylomeDB" id="B8M144"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="4">
        <location>
            <begin position="687"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED20986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1048" mass="116279" checksum="8ECB78121A4AE157" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8M156</accession>
    <name>B8M156_TALSN</name>
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        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">TSTA_082310</name>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477961.1">
        <property type="nucleotide sequence ID" value="XM_002477916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M156"/>
    <dbReference type="STRING" id="441959.B8M156"/>
    <dbReference type="GeneID" id="8107689"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_082310"/>
    <dbReference type="eggNOG" id="KOG2688">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017745_0_0_1"/>
    <dbReference type="InParanoid" id="B8M156"/>
    <dbReference type="OMA" id="IPCNIIM"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="PhylomeDB" id="B8M156"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF8">
        <property type="entry name" value="NUCLEAR MRNA EXPORT PROTEIN THP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED20998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="609" mass="67519" checksum="11F76B7C4F8CCC5F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1D6</accession>
    <name>B8M1D6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CorA family metal ion transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_090720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
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        <property type="protein sequence ID" value="EED21832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002478750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1D6"/>
    <dbReference type="FunCoup" id="B8M1D6">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M1D6"/>
    <dbReference type="GeneID" id="8101562"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_090720"/>
    <dbReference type="eggNOG" id="ENOG502QPTQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007127_10_0_1"/>
    <dbReference type="InParanoid" id="B8M1D6"/>
    <dbReference type="OMA" id="NEQWDIA"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="PhylomeDB" id="B8M1D6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000008">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000014">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="812"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="847"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="421"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="687"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="451"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="497"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="688"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED21832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="875" mass="99156" checksum="7C36F73A075D1A21" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1E3</accession>
    <name>B8M1E3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA ligase/cyclic nucleotide phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_090790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478802.1">
        <property type="nucleotide sequence ID" value="XM_002478757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1E3"/>
    <dbReference type="STRING" id="441959.B8M1E3"/>
    <dbReference type="GeneID" id="8101569"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_090790"/>
    <dbReference type="eggNOG" id="ENOG502S7CF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051290_0_0_1"/>
    <dbReference type="InParanoid" id="B8M1E3"/>
    <dbReference type="OMA" id="FVDPRNC"/>
    <dbReference type="OrthoDB" id="2967263at2759"/>
    <dbReference type="PhylomeDB" id="B8M1E3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="35479" checksum="E72526429F1F7A29" modified="2009-03-03" version="1">MAAVMFEDLSGTATPVSKSDNPYQPLLDSANDDPLQIQARYTTHRTTRTALQKSKILDPSFSEWTVDPILAKLDGPNKDPAFKDERNCIVFWARPPQHIRDMIRDIQEELRNVAPDMWFMPLQNLHITVLEVIFSVTEPEVNQIVSALLKDGAAENIANITLRYRPRLVKPMISYDAAAMALSFVPAAGEGSKSVDEDKYTYHHLRRDVYDKVVAAGVKPASRYAVPSAHLTIGRFINQNGFTLDGPDGTAFDREKAKKVIDKVEEINDRLQKRFWPTEAGVPKGGEWTIGEEKGLDFRKGTLWYGGGETVVLGKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1I3</accession>
    <name>B8M1I3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_091200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478842.1">
        <property type="nucleotide sequence ID" value="XM_002478797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1I3"/>
    <dbReference type="FunCoup" id="B8M1I3">
        <property type="interactions" value="106"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M1I3"/>
    <dbReference type="GeneID" id="8101609"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_091200"/>
    <dbReference type="eggNOG" id="KOG0335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_18_0_1"/>
    <dbReference type="InParanoid" id="B8M1I3"/>
    <dbReference type="OMA" id="HSTIDFI"/>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="PhylomeDB" id="B8M1I3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="199"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="468"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="40"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED21879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="640" mass="71776" checksum="9D3001BC19A028D1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1K9</accession>
    <name>B8M1K9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="9">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_093420</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 9">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="9"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479059.1">
        <property type="nucleotide sequence ID" value="XM_002479014.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B8M1K9">
        <property type="interactions" value="713"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M1K9"/>
    <dbReference type="GeneID" id="8102586"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_093420"/>
    <dbReference type="eggNOG" id="KOG1140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000684_1_0_1"/>
    <dbReference type="InParanoid" id="B8M1K9"/>
    <dbReference type="OMA" id="GEASYMC"/>
    <dbReference type="OrthoDB" id="26387at2759"/>
    <dbReference type="PhylomeDB" id="B8M1K9"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16482">
        <property type="entry name" value="RING-H2_UBR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19673">
        <property type="entry name" value="UBR-box_UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase UBR2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2670:FF:000004">
        <property type="entry name" value="Ubiquitin-protein ligase E3 component (UBR1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="11">
        <location>
            <begin position="83"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="8">
        <location>
            <begin position="83"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="389"/>
            <end position="435"/>
        </location>
    </feature>
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        <location>
            <begin position="458"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1596"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="396"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1616"/>
            <end position="1625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED22096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="2142" mass="242585" checksum="8292AEBA56232945" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1T2</accession>
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        <name evidence="4" type="ORF">TSTA_085410</name>
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        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    <dbReference type="EMBL" id="EQ962653">
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    </dbReference>
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    <dbReference type="GeneID" id="8106147"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_085410"/>
    <dbReference type="eggNOG" id="ENOG502QV54">
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051801">
        <property type="entry name" value="GH28_Enzymes"/>
    </dbReference>
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        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
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        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
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        <property type="entry name" value="PECTIN LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31339:SF9">
        <property type="entry name" value="PLASMIN AND FIBRONECTIN-BINDING PROTEIN A"/>
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    </dbReference>
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    </dbReference>
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            <end position="18"/>
        </location>
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            <end position="906"/>
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        <location>
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            <end position="599"/>
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            <end position="515"/>
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        </location>
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        </location>
    </feature>
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            <begin position="490"/>
            <end position="507"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED21310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="906" mass="94909" checksum="06D6DFCA52BFA494" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2B0</accession>
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        <submittedName>
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        </submittedName>
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        <name evidence="4" type="ORF">TSTA_088100</name>
    </gene>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="protein sequence ID" value="EED21574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002478492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2B0"/>
    <dbReference type="STRING" id="441959.B8M2B0"/>
    <dbReference type="GeneID" id="8106907"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_088100"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_15_2_1"/>
    <dbReference type="InParanoid" id="B8M2B0"/>
    <dbReference type="OMA" id="EMGYWDN"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="PhylomeDB" id="B8M2B0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051122">
        <property type="entry name" value="SDR_DHRS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057571">
        <property type="entry name" value="SDR_PhqE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477:SF1">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23441">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED21574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="300" mass="32279" checksum="9B0BF0AAF9875205" modified="2009-03-03" version="1">MAGSMPLKYMSKLAGSRVLILGGTSGIGFAVAEAALEHGATVIISSSRENKLQNALSRLREAYPDPTYHARINGYTCDLGTPENLDENIAKLLAQVTKNSPSERADDQRDDPALLDHIIYTAGDAIKVTPVPDLTVDTIQRMGTVRFMGPLLLSKLAPRYMKKSSTSSITLTSGSQSLKPMPNWTAVVAYSTGTEGMMRGLAVDLAPIRVNCVAPGAVHTELFNDISADRLDSVLESMASATLVGKVGKPEDVAEAYLYAMKDGFYCFSGGLEVYTLLILCNLWRLEAKGISVFKSLVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2F4</accession>
    <name>B8M2F4_TALSN</name>
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        <recommendedName>
            <fullName evidence="3">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_088540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478581.1">
        <property type="nucleotide sequence ID" value="XM_002478536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2F4"/>
    <dbReference type="STRING" id="441959.B8M2F4"/>
    <dbReference type="GeneID" id="8106951"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_088540"/>
    <dbReference type="eggNOG" id="KOG1840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1788104_0_0_1"/>
    <dbReference type="InParanoid" id="B8M2F4"/>
    <dbReference type="OMA" id="VEWEVDN"/>
    <dbReference type="OrthoDB" id="4226826at2759"/>
    <dbReference type="PhylomeDB" id="B8M2F4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED21618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="15306" checksum="C240CD9184E9A34B" modified="2009-03-03" version="1">MCKSGVTQDDYTGMDLCLAAGNDGGEPSTDHNSYTLGRVSGHNVVVACLPSGVSGTTSAAIMLAHMLPTFPSLRFGLMVGIGGAVPSKTADIRLGDVVISMPTANSGDVTQYDYGKKIRDGVFKRTGSLNKPLQYWQYPKYAVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2G2</accession>
    <name>B8M2G2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA binding protein Ligatin/Tma64, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_088620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478589.1">
        <property type="nucleotide sequence ID" value="XM_002478544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2G2"/>
    <dbReference type="FunCoup" id="B8M2G2">
        <property type="interactions" value="484"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M2G2"/>
    <dbReference type="GeneID" id="8106959"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_088620"/>
    <dbReference type="eggNOG" id="KOG2522">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012487_1_1_1"/>
    <dbReference type="InParanoid" id="B8M2G2"/>
    <dbReference type="OMA" id="MFLKPYR"/>
    <dbReference type="OrthoDB" id="199771at2759"/>
    <dbReference type="PhylomeDB" id="B8M2G2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11608">
        <property type="entry name" value="eIF2D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21156">
        <property type="entry name" value="PUA_eIF2d-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000008">
        <property type="entry name" value="eukaryotic translation initiation factor 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.400.20:FF:000008">
        <property type="entry name" value="RNA binding protein Ligatin/Tma64, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039757">
        <property type="entry name" value="EIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039759">
        <property type="entry name" value="eIF2D_SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048248">
        <property type="entry name" value="PUA_eIF2d-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057429">
        <property type="entry name" value="WH_eIF2D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26292">
        <property type="entry name" value="PUA_elF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25304">
        <property type="entry name" value="WHD_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="2">
        <location>
            <begin position="559"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED21626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="649" mass="71675" checksum="BDB6F253770D5EA6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2Q4</accession>
    <name>B8M2Q4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_092070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478928.1">
        <property type="nucleotide sequence ID" value="XM_002478883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2Q4"/>
    <dbReference type="STRING" id="441959.B8M2Q4"/>
    <dbReference type="GeneID" id="8098592"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_092070"/>
    <dbReference type="eggNOG" id="ENOG502SBKV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097632_0_1_1"/>
    <dbReference type="InParanoid" id="B8M2Q4"/>
    <dbReference type="OMA" id="GFAESMH"/>
    <dbReference type="OrthoDB" id="6222486at2759"/>
    <dbReference type="PhylomeDB" id="B8M2Q4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09271">
        <property type="entry name" value="RNase_H2-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013924">
        <property type="entry name" value="RNase_H2_suC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47204">
        <property type="entry name" value="OS02G0168900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47204:SF1">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08615">
        <property type="entry name" value="RNase_H2_suC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED21965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="153" mass="17127" checksum="2AEEE99DA3B62AFB" modified="2009-03-03" version="1">MLALRSAPKSSNSKEALTGNCTPNILPCRIHYDGPIDTSKRHWHAINDEKEDKQTAYFRGRKLQGRTVQLPEAYQGVVAFPTDRMVPAANREGAVPEEPVKILESQATFDQFVVWGHENLPAADDTFVKGVNEWIKLAEAMHGDSREPETITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2X0</accession>
    <name>B8M2X0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_094710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479188.1">
        <property type="nucleotide sequence ID" value="XM_002479143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2X0"/>
    <dbReference type="GeneID" id="8103801"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_094710"/>
    <dbReference type="eggNOG" id="ENOG502T1RW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1349697_0_0_1"/>
    <dbReference type="InParanoid" id="B8M2X0"/>
    <dbReference type="OrthoDB" id="4147798at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="203" mass="23430" checksum="00572E9044FF4F76" modified="2009-03-03" version="1">MGQRHNRRRTRPRSRNRAASLDSLRSSSSSIDYRQEPAASSPVHKFSEPVVLVPLAHTRHNWLEEWQSSEFNESFDAEQQQCRYFGGEPGDDENLCYYMLDYFEIIQHRRMKKDKTITTTDRREPSIVSASSGLLLLSCLSIRLVNESTIVTNQSFSDVIPYRNSANPKHLVTSVRTIRAVRLVAMKRVVLLKGRTYTWIGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3K4</accession>
    <name>B8M3K4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxidative stress-induced growth inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_096250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479339.1">
        <property type="nucleotide sequence ID" value="XM_002479294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3K4"/>
    <dbReference type="STRING" id="441959.B8M3K4"/>
    <dbReference type="GeneID" id="8103468"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_096250"/>
    <dbReference type="eggNOG" id="ENOG502QRUQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026100_0_0_1"/>
    <dbReference type="InParanoid" id="B8M3K4"/>
    <dbReference type="OMA" id="ASWDIQT"/>
    <dbReference type="OrthoDB" id="412005at2759"/>
    <dbReference type="PhylomeDB" id="B8M3K4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029731">
        <property type="entry name" value="OSGIN1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15192:SF8">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15192">
        <property type="entry name" value="PROTEIN CBG05349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED22376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="58373" checksum="FE9B69F9C3DBFB5E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3N8</accession>
    <name>B8M3N8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginyltransferase</fullName>
            <ecNumber evidence="2">2.3.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_096590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the R-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.8" evidence="2"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479373.1">
        <property type="nucleotide sequence ID" value="XM_002479328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3N8"/>
    <dbReference type="FunCoup" id="B8M3N8">
        <property type="interactions" value="616"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M3N8"/>
    <dbReference type="GeneID" id="8103502"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_096590"/>
    <dbReference type="eggNOG" id="KOG1193">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020349_0_0_1"/>
    <dbReference type="InParanoid" id="B8M3N8"/>
    <dbReference type="OMA" id="KYQTAIH"/>
    <dbReference type="OrthoDB" id="74183at2759"/>
    <dbReference type="PhylomeDB" id="B8M3N8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007471">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04376">
        <property type="entry name" value="ATE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-end aminoacyl transferase N-terminal" evidence="5">
        <location>
            <begin position="74"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="6">
        <location>
            <begin position="225"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED22410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="494" mass="56829" checksum="B7661FA0694DF543" modified="2009-03-03" version="1">MSTVVDAETARNLSLFRPLGEYFSPASQSESLQPPRAASTGLGVRLHPGSRASVLQSSFCLHADWLRIGYQRNSCGYCKSPDGSASYYASSVSVRPEHYEILVNRGWRRSGTLYYKQNLQRSCCPHYTLRLDVSEYKPRRDQRKAINRWNKYVLGQEYIRKAAMLAPKSREEKRQRKKHFDIVRAVHEAEYSNLRRPIDPKTKRPIEPAHKFEVSIEGDSISQRKYEVFLEYQQTIHQESTDRWKNADFKRFLCSGLKRNTPKEGSGEKRLGSWHQCYRLDGRLIAVAVLDLLPEGVSSVYLYYDPEFGDWELGKLSALREIAFALEEGYKYYYMGYYIHTCQKMRYKALYRPQYVLDPESMTWDPLDGELTGKLNKRKYVSLSRDRARGLSASENNETEAEKEDELPELVNEESLSLFEINMPGVLTAEEVLTQFDLDHWLLLVHGTFVHMEDLVGWESAKITDSQSVKGIVGELVAVLGLEVASMSGCVLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4L8</accession>
    <name>B8M4L8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_025310</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479647.1">
        <property type="nucleotide sequence ID" value="XM_002479602.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479648.1">
        <property type="nucleotide sequence ID" value="XM_002479603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4L8"/>
    <dbReference type="FunCoup" id="B8M4L8">
        <property type="interactions" value="299"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M4L8"/>
    <dbReference type="GeneID" id="8106748"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_025310"/>
    <dbReference type="eggNOG" id="KOG1589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099502_0_1_1"/>
    <dbReference type="InParanoid" id="B8M4L8"/>
    <dbReference type="OMA" id="FRQNFYQ"/>
    <dbReference type="OrthoDB" id="869189at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED19213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="183" mass="19925" checksum="B4698359D58801CB" modified="2009-03-03" version="1">MSSSRVGLRFLANSRAAFRNFRQNVSNNSKGFRFSSTDASATAGEQQSTFQRLWNSPVGVKTVHFWAPVMKWSLVIAGISDLARPAEKLSLTQNLALMATGSIWTRWCFVITPKNMLLAAVNFFLACTGLAQVTRIFLWRRSQDGSATEAAKDLAEDTVGSAKAVTDSAKGVVKAAEEKVKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4Y2</accession>
    <name>B8M4Y2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Cation transporting ATPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSTA_027160</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[protein]-with a C-terminal TM segment(out) + ATP + H2O = [protein]-with a C-terminal TM segment(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66168"/>
            <dbReference type="Rhea" id="RHEA-COMP:16963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:90782"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479851.1">
        <property type="nucleotide sequence ID" value="XM_002479806.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B8M4Y2">
        <property type="interactions" value="1138"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M4Y2"/>
    <dbReference type="GeneID" id="8109635"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_027160"/>
    <dbReference type="eggNOG" id="KOG0209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001828_4_0_1"/>
    <dbReference type="InParanoid" id="B8M4Y2"/>
    <dbReference type="OMA" id="QKTKYVW"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="PhylomeDB" id="B8M4Y2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07543">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000049">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000054">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000071">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
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        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047820">
        <property type="entry name" value="P5A-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23143">
        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="P5A-ATPase transmembrane helical hairpin" evidence="17">
        <location>
            <begin position="33"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="16">
        <location>
            <begin position="273"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1279"/>
            <end position="1298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048588"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23143"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED19417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1298" mass="144910" checksum="C0195894774D44CA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4Z1</accession>
    <name>B8M4Z1_TALSN</name>
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        <submittedName>
            <fullName evidence="3">Siderophore biosynthesis enzyme, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_027230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002479815.1"/>
    </dbReference>
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    <dbReference type="STRING" id="441959.B8M4Z1"/>
    <dbReference type="GeneID" id="8109642"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_027230"/>
    <dbReference type="eggNOG" id="ENOG502SQMT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_685453_0_0_1"/>
    <dbReference type="InParanoid" id="B8M4Z1"/>
    <dbReference type="OrthoDB" id="3942074at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877543" evidence="2">
        <location>
            <begin position="18"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="402" mass="41736" checksum="C447D4C0CCCD1D9D" modified="2009-03-03" version="1">MLPYTLSLLMLVASVFADCATISFTHCADNIVHWYNPNTGEICDPLDCGGGRAPPKTDVPGCPLYKGTETRATSASYLPCWTPLNAAPATVAVAATTSTSVAEAATSATAPLLASSATSTGAPVPESSTTTTTTAAVSSAGTTTVPTTITSAATTSIPSTTAASSVSYAAPSVSSAAGDTGAHSTSSAAVPPKPTGSNAGNILDGSLMAVAGAAIDQIYPHYYTVNSKRSCNLKPRRSEVTPFMSWILSIQTALGGSAEDFNISIQATRCSAMISEGLRLDPGLRACFPDKIRSKAYCSGVSIPVAPHGLYSRLESSNVDPVFEDLDSLDEVQVFFETAENPDVPDIDPSPIYSVTHVDISPEFKRRLVKANSPDPKLSKAFQDSDLNDDKEASLPSVVHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8M535</accession>
    <name>B8M535_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_029180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="protein sequence ID" value="EED19641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002480030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M535"/>
    <dbReference type="STRING" id="441959.B8M535"/>
    <dbReference type="GeneID" id="8099037"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_029180"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="InParanoid" id="B8M535"/>
    <dbReference type="OMA" id="YMTGTDF"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="PhylomeDB" id="B8M535"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF63">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED19641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="280" mass="29635" checksum="1CCE02CFD1FF91E7" modified="2009-03-03" version="1">MATAPRGRLQGKNAIITGAAGGIGLETSILFAREGASVLMADISEPALATALAKVKSLAPSSARVETIKCDVSKESDVQAMVESQDSWGGTDIIFNNAGIMHADDADAVDTSDKIWDLTHNINVKGVWYGCKHTVLSLRRHKKTKGSIINTASVVALVGSATPQLAYTASKGAVLALTRELAIVHAREGFRFNALCPAPLNTPLLQDWLGDDQAKRHRREVHFPTGRFGEAIEQANAVVFLASDEASFVNGTDFVVDGGMTKAYVTPEGPPTAAPQNLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8M541</accession>
    <name>B8M541_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_029240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480081.1">
        <property type="nucleotide sequence ID" value="XM_002480036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M541"/>
    <dbReference type="STRING" id="441959.B8M541"/>
    <dbReference type="GeneID" id="8099043"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_029240"/>
    <dbReference type="eggNOG" id="KOG3425">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120161_2_0_1"/>
    <dbReference type="InParanoid" id="B8M541"/>
    <dbReference type="OMA" id="MPLITDF"/>
    <dbReference type="OrthoDB" id="78947at2759"/>
    <dbReference type="PhylomeDB" id="B8M541"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000304">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.12, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045108">
        <property type="entry name" value="TXNDC17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010357">
        <property type="entry name" value="TXNDC17_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452">
        <property type="entry name" value="42-9-9 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06110">
        <property type="entry name" value="TXD17-like_Trx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="19"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="133" mass="14857" checksum="FBFE263144A0165E" modified="2009-03-03" version="1">MPIITDYKLPSSVDALDLTAESNSPFFISFHASRDPNTGEPWCPDVRAALPPLKAAFSADAGPRVAFIEVGHRPEWRDTTNVYRTKWNVRNLPTLARYERVDGKVKEVGRLVEGEILDSKRLKEFINGSSASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8M551</accession>
    <name>B8M551_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_029340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480091.1">
        <property type="nucleotide sequence ID" value="XM_002480046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M551"/>
    <dbReference type="STRING" id="441959.B8M551"/>
    <dbReference type="GeneID" id="8099053"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_029340"/>
    <dbReference type="eggNOG" id="ENOG502QWD2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073157_0_0_1"/>
    <dbReference type="InParanoid" id="B8M551"/>
    <dbReference type="OMA" id="GADTMCL"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="PhylomeDB" id="B8M551"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF22">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="33857" checksum="93833AD86FC61F6B" modified="2009-03-03" version="1">MLELTDDTFKRKVSSVTGLALQPNTEHCQDLSKLGAKIIPHEPGRGFKQAVQTLKDAQIDAICLIPPAHRDKLEITLELIEVAKQAGVPNVCLLSSAGCDLAERDRQPRLREFVDIEAQMMATKGDASTSTGHSPVIIRAGFSAENLLLYSKQAQEEGILPLLIGKDHKFGPVALGVFAPHVMTGKGKHGFADKHRGQLMVVTGPMLATGDELATAASKALDTNLKFEDISLFQAKKILKAESTSDEAELEYLLEYYSLVREGKTNYISTTAFHDVTGIHPQEPPEFFNVYAESFHPKHASKKRKVNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8M596</accession>
    <name>B8M596_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycerol-3-phosphate O-acyltransferase, putative</fullName>
            <ecNumber evidence="4">2.3.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_029750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.15" evidence="4"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480136.1">
        <property type="nucleotide sequence ID" value="XM_002480091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M596"/>
    <dbReference type="FunCoup" id="B8M596">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M596"/>
    <dbReference type="GeneID" id="8106542"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_029750"/>
    <dbReference type="eggNOG" id="ENOG502QQ2N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007860_1_0_1"/>
    <dbReference type="InParanoid" id="B8M596"/>
    <dbReference type="OMA" id="IMALGCM"/>
    <dbReference type="OrthoDB" id="2427554at2759"/>
    <dbReference type="PhylomeDB" id="B8M596"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07992">
        <property type="entry name" value="LPLAT_AAK14816-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="470"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="3">
        <location>
            <begin position="50"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED19702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="701" mass="78617" checksum="72B5B3AE0B7A8648" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5J4</accession>
    <name>B8M5J4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1168 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_031470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480322.1">
        <property type="nucleotide sequence ID" value="XM_002480277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5J4"/>
    <dbReference type="STRING" id="441959.B8M5J4"/>
    <dbReference type="GeneID" id="8107758"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_031470"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_079129_1_1_1"/>
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    <dbReference type="PhylomeDB" id="B8M5J4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:double-stranded RNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:protein kinase binding"/>
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    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
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    <dbReference type="InterPro" id="IPR009548">
        <property type="entry name" value="Prkrip1"/>
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        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507:SF0">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06658">
        <property type="entry name" value="DUF1168"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="205"/>
        </location>
    </feature>
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        <location>
            <begin position="91"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="205" mass="23355" checksum="CDB6582C79963A3A" modified="2009-03-03" version="1">MSEPGKESIPTSADPRSKRPTKRRQLTPVSEQANQINVLFKDPIREVHLPPISKPRTLDSLAPPPEIVANVQGSSAGAGSGEFHVYKASRRREYERIRLMEEESKREKSNEEFEKKRAETIRKDQEKTERNRRKREKRKAAAAKTKNGNSSTAMDVDGDAEKKPKQALSRLGPLPPRDRDQDTQVDDNNEEQRSHEEQGVIIHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5L5</accession>
    <name>B8M5L5_TALSN</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="3" type="ORF">TSTA_031690</name>
    </gene>
    <organism evidence="3 4">
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        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002480298.1"/>
    </dbReference>
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        <property type="interactions" value="140"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M5L5"/>
    <dbReference type="GeneID" id="8107779"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_031690"/>
    <dbReference type="eggNOG" id="KOG1983">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006030_0_0_1"/>
    <dbReference type="InParanoid" id="B8M5L5"/>
    <dbReference type="OMA" id="QIYVFGQ"/>
    <dbReference type="OrthoDB" id="19944at2759"/>
    <dbReference type="PhylomeDB" id="B8M5L5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000848">
        <property type="entry name" value="SNARE-dependent exocytosis protein (Sro7), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013905">
        <property type="entry name" value="Lgl_C_dom"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="TOMOSYN, ISOFORM C"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lethal giant larvae (Lgl)-like C-terminal" evidence="2">
        <location>
            <begin position="518"/>
            <end position="907"/>
        </location>
    </feature>
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        <location>
            <begin position="918"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="998" mass="108812" checksum="1C53877478DC35E3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8M638</accession>
    <name>B8M638_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBF1-interacting co-repressor CIR N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_023730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479472.1">
        <property type="nucleotide sequence ID" value="XM_002479427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M638"/>
    <dbReference type="GeneID" id="8109555"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_023730"/>
    <dbReference type="eggNOG" id="ENOG502RR25">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047019_0_0_1"/>
    <dbReference type="InParanoid" id="B8M638"/>
    <dbReference type="OMA" id="KRYSAQF"/>
    <dbReference type="OrthoDB" id="2159131at2759"/>
    <dbReference type="PhylomeDB" id="B8M638"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039875">
        <property type="entry name" value="LENG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER LRC MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093:SF0">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="339" mass="40031" checksum="E15F9A129B88BF59" modified="2009-03-03" version="1">MPLHLLGKKSWNVYNPENIARVHRDEAQAKAREEEEERRMQEIDAERRIQLLRGEYPSNLPPSIPPAPTETAQPGSYGRPESEFGVFRHKKRRRIAGEDDTDRDIRFAREDAVQYDARRDELLSSGRKGKNREEHVPIVDGTGHINLFTEDMTRQQRAEKNAEAEAEKHKKQRVFEDQYTMRLSNASGFKESAGQTPWYSANSKDAQAPNAMRGTDVWGNEDPLRQEREKARTNANDPLAAMKSGVRGLKNSQRERKEWQKQRLREIEDLERAQRSEHRRRRRRRPHSPDSLNSLEGFSLDKDSRKHSDESHETLRRSHKHEYQEHQRRHRHHHRRHHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6B2</accession>
    <name>B8M6B2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_026020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479721.1">
        <property type="nucleotide sequence ID" value="XM_002479676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6B2"/>
    <dbReference type="FunCoup" id="B8M6B2">
        <property type="interactions" value="96"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M6B2"/>
    <dbReference type="GeneID" id="8108014"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_026020"/>
    <dbReference type="eggNOG" id="KOG2852">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_14_0_1"/>
    <dbReference type="InParanoid" id="B8M6B2"/>
    <dbReference type="OMA" id="DDTVYAC"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="PhylomeDB" id="B8M6B2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF150">
        <property type="entry name" value="OXIDOREDUCTASE TDA3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="403" mass="42679" checksum="EC90929FCD952864" modified="2009-03-03" version="1">MASETQRNIVIIGGGIIGSCSAYYLTRHPSYDPALHKITLIEASEIAGGASGKAGGLLALWAYPSSIVPLSYKLHAELAKEHNGKDNWGYREVNCGQLIVKGQVIDKKSNADDASVSLQKRDAAAIGKLRAAGIPAGLDWVLSDGIRGYESMSGPGETAQVHPYQFTTSIAKLAEEKGVNIILGKVTRINQEAGAVQSVTFTDKASGEAHTVPATDVIVSAGPWTKRIIPSAPITATRAHSVVIRPTRPVSAYTLFTNIELPSKHNPKRSTVETPEIYARPDTTVYACGDGDRAVPLPETSADVEVDPKRCQDIIDSVGSISDELRLGEVVKQQACYLPNVDARGGGGPLIGHSGTKGLYVATGHTCWGIQNAPGTGKLISEFVFEGGARSAKIAALDPQRFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8M790</accession>
    <name>B8M790_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA polymerase I-specific transcription initiation factor RRN6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_035370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480744.1">
        <property type="nucleotide sequence ID" value="XM_002480699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M790"/>
    <dbReference type="STRING" id="441959.B8M790"/>
    <dbReference type="GeneID" id="8107487"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_035370"/>
    <dbReference type="eggNOG" id="ENOG502QRAW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005807_0_0_1"/>
    <dbReference type="InParanoid" id="B8M790"/>
    <dbReference type="OMA" id="DLPMTQV"/>
    <dbReference type="OrthoDB" id="4090074at2759"/>
    <dbReference type="PhylomeDB" id="B8M790"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001179">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001163">
        <property type="term" value="F:RNA polymerase I transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019350">
        <property type="entry name" value="RNA_pol_I-sp_TIF_RRN6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048535">
        <property type="entry name" value="RRN6_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048537">
        <property type="entry name" value="RRN6_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048536">
        <property type="entry name" value="Rrn6_K-rich"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221:SF2">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10214">
        <property type="entry name" value="Rrn6_beta-prop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20640">
        <property type="entry name" value="Rrn6_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20639">
        <property type="entry name" value="Rrn6_K-rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRN6 beta-propeller" evidence="2">
        <location>
            <begin position="101"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="RRN6 helical bundle" evidence="4">
        <location>
            <begin position="575"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="RRN6 K-rich C-terminal" evidence="3">
        <location>
            <begin position="839"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="862"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="947"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="872"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="889"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="955"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED20310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="968" mass="108672" checksum="8D86D62F8B9268F9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7U0</accession>
    <name>B8M7U0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF636 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_030820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480253.1">
        <property type="nucleotide sequence ID" value="XM_002480208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7U0"/>
    <dbReference type="STRING" id="441959.B8M7U0"/>
    <dbReference type="GeneID" id="8101761"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_030820"/>
    <dbReference type="eggNOG" id="ENOG502S2MN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055491_3_1_1"/>
    <dbReference type="InParanoid" id="B8M7U0"/>
    <dbReference type="OMA" id="RYICVGS"/>
    <dbReference type="OrthoDB" id="4213482at2759"/>
    <dbReference type="PhylomeDB" id="B8M7U0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="4"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED19819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="141" mass="15452" checksum="9F629BC798142543" modified="2009-03-03" version="1">MTTLTGSCYCQNIKYEVTLNSPDDARTSLCHCRNCKKAFGANYGLTAKIPKDALKITQGKPKGHSADNGSGMVINREFCGNCGSFILEYGEAVKNKFRYIVVGSLDDPEALPPKGEFFCKDRVSWMPEVPSKSTFHADLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7V3</accession>
    <name>B8M7V3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dimethylaniline monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_030970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480266.1">
        <property type="nucleotide sequence ID" value="XM_002480221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7V3"/>
    <dbReference type="STRING" id="441959.B8M7V3"/>
    <dbReference type="GeneID" id="8101774"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_030970"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019225_1_0_1"/>
    <dbReference type="InParanoid" id="B8M7V3"/>
    <dbReference type="OMA" id="ILGQIHT"/>
    <dbReference type="OrthoDB" id="2915840at2759"/>
    <dbReference type="PhylomeDB" id="B8M7V3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED19832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="600" mass="67476" checksum="EAE832EF169D7BDA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8M809</accession>
    <name>B8M809_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RTA1 domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_032270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480405.1">
        <property type="nucleotide sequence ID" value="XM_002480360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M809"/>
    <dbReference type="STRING" id="441959.B8M809"/>
    <dbReference type="GeneID" id="8099840"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_032270"/>
    <dbReference type="eggNOG" id="ENOG502QU4U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033465_6_1_1"/>
    <dbReference type="InParanoid" id="B8M809"/>
    <dbReference type="OMA" id="HEPSFIV"/>
    <dbReference type="OrthoDB" id="4521223at2759"/>
    <dbReference type="PhylomeDB" id="B8M809"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED19971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="331" mass="35926" checksum="299481B79DF36358" modified="2009-03-03" version="1">MPSSHASCTEVSAQCPVEATTLGYYPNLGANIFFVVLYALCTIFTLGVGLWKKTWVFGVVVSAGFALETCGYIGRVLMHYNPWSDPGFKLDLVCIILAPTLICAGIYLTLKHVARTVGPDFSRITPRLYTWIFIPFDVFCLCLQGVGGGVDAAASDKTPIDEKTLKTGNDIIIAGIALQVVNLAVFGLLSLDFFVSAMKHFKNPSEKVRNSANAQIWYSRRFRVFCSAIACAYAGILVRCIYRVAEMAGGWGNSIMRNEVLFYVLEGAMVLYPAMLLTIFAPGFYFPEMGSSNALLTSSTDTATGTENNAVVSNEGYKPGTPEEGAESSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8N2</accession>
    <name>B8M8N2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hscarg dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_037630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480979.1">
        <property type="nucleotide sequence ID" value="XM_002480934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8N2"/>
    <dbReference type="STRING" id="441959.B8M8N2"/>
    <dbReference type="GeneID" id="8102139"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_037630"/>
    <dbReference type="eggNOG" id="ENOG502SHS9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_8_6_1"/>
    <dbReference type="InParanoid" id="B8M8N2"/>
    <dbReference type="OMA" id="HHPPGTD"/>
    <dbReference type="OrthoDB" id="3358371at2759"/>
    <dbReference type="PhylomeDB" id="B8M8N2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF26">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED20545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="327" mass="36386" checksum="377216B8E9A8506B" modified="2009-03-03" version="1">MSKLIVIVGVTGLQGSSVANTFLNLPGWKVRGISRNPSSPTAQALISKGAEIIQADLDDEKSLYPAFESANVIFSNTDFFGIFFHALMSKNDSPQQYAYDREVEQGINIARAAASPTVLRTLDRFVLSSLSDARKWSQGKYPNVYHNNSKIEIIQTIETQFPELAERMSMVQVGHYATNWKQSPSLAPQKQSDGSFIVKRTFTSDFKMPFVVPHKDTGEFVRALTLDLPAGTHILGASEILTLPEWTKIWAETLGVKAVFEQVTFDIFFQGVPDEMKRELSETFAYTNEFGYTGGDPAIKTAEQLGIKLSLTSMEEYIKGEDWSSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9I7</accession>
    <name>B8M9I7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_117650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481981.1">
        <property type="nucleotide sequence ID" value="XM_002481936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9I7"/>
    <dbReference type="STRING" id="441959.B8M9I7"/>
    <dbReference type="GeneID" id="8105823"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_117650"/>
    <dbReference type="eggNOG" id="ENOG502S6H7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045947_1_0_1"/>
    <dbReference type="InParanoid" id="B8M9I7"/>
    <dbReference type="OMA" id="KVMHVQD"/>
    <dbReference type="OrthoDB" id="2017497at2759"/>
    <dbReference type="PhylomeDB" id="B8M9I7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08589">
        <property type="entry name" value="PI-PLCc_SaPLC1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032075">
        <property type="entry name" value="PI-PLC-C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16670">
        <property type="entry name" value="PI-PLC-C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002874867" description="Acid phosphatase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="49923" checksum="AF8E322A3127662F" modified="2009-03-03" version="1">MAMTMREIVLCAALIFVIGVSVLNQTVNSTSSLSNQLLQNDQSALSSTSPSMIHLQQQQKQHDQDQKLRLNNLQVIGTHNSYHREVSLPERIHFPYLMADVDQHVEGYYYSHASVHDQLEHQQVRSFEFDVYVDTHGGLFADPLIRRIANMSESDNAHYGLPEDVMRQPGTKVLHIADADVGTICHTLVECLTQVKAWSESKKGLHVPIPILIEFKKTEPGLELQGGVVAEDWTVDALDRVDAEIRSVFSDDQLITPDDLRKHAMDNGVVSRNSNKNITLEEAILAFEHGGGWPTLSSSRGKFFFVMDNEPTHPIQIRDPYRSGGRTNLEGRVIFTNSLPGEPDAAFIKRNNPITGNNQHQIQELVSKGYFIRTRADEPIQMLLTDEVPAMRDAALASGAQIVSSDWVGAGVSARYNSDYFVALPLGGAARCNPVNAPKGCVDEYLELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAX4</accession>
    <name>B8MAX4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_124040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482667.1">
        <property type="nucleotide sequence ID" value="XM_002482622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAX4"/>
    <dbReference type="STRING" id="441959.B8MAX4"/>
    <dbReference type="GeneID" id="8098355"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_124040"/>
    <dbReference type="eggNOG" id="ENOG502S2ZX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_4_2_1"/>
    <dbReference type="InParanoid" id="B8MAX4"/>
    <dbReference type="OMA" id="MAYQMAK"/>
    <dbReference type="OrthoDB" id="4033386at2759"/>
    <dbReference type="PhylomeDB" id="B8MAX4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="60"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED18675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="372" mass="43083" checksum="F76B007CD3D4D11C" modified="2009-03-03" version="1">MPPIRNKNEKNLAEQEGRILLAISDLKNGKISSVYQAAIIYNIPRTTLYDRLNGIQQRSIIRANGHKLSQFEEESLVKWVLDLDKRGLPPRHSLVREMANYLLSQRGNQQVGEKWVYNLIQRRPEIESKFSRKYNYERAKCEDPKLIQEYFDRVREVISKYGILLEDIYNFDETGFAMGLCATAKVITGSDRYARPKLLQPGNREWVTAIEVINSTGWALPSYIIFKAKKYTWLGWFEDLPDDWRINISDNGWTTDKIGLEWLKTHFIPLTNGRAMGNYRMLILDGHGSHLTAEFDRTCTENNIIPPLDVGCFAVLKRHYGQLVEQQMRLGFNHIDKLDFLTAFPKARTMAYKAQTVRNSFTVTGLVPFNPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8MB19</accession>
    <name>B8MB19_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_124440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482712.1">
        <property type="nucleotide sequence ID" value="XM_002482667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MB19"/>
    <dbReference type="GeneID" id="8098395"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_124440"/>
    <dbReference type="eggNOG" id="ENOG502SPS8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053555_1_0_1"/>
    <dbReference type="InParanoid" id="B8MB19"/>
    <dbReference type="OMA" id="NCCEISG"/>
    <dbReference type="OrthoDB" id="3538998at2759"/>
    <dbReference type="PhylomeDB" id="B8MB19"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002874930" description="GPI anchored protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="36079" checksum="996CF1B2AF8B0C10" modified="2009-03-03" version="1">MLSRTIFRALIALEAAATLALAQTNITADVCADPSAFTSCTTQALATSKGCTDMCNGSKMCVLGCGCAMYQSYINCVAESCWNQAYSCEYDKLVAAYFSQCSTAAEPIPFWPAPDSAPGGCSCNLGKVLQSVTKAQQEYNTCITNDTSTSVIQQGNQNTACGCCEVSAGLSAMYETCPDTIPADMGADIWLQASTIYGTVIHWDKCGSVLDQYNCHNLGFAPPSSNSSTFYKPANLPPNGTLTLYNTGPANAVTAPPSGSVFTWSQSSVMYTVTASPWKNGQIMVTSTSIATTKTSSTVTGTSSTVPPGATSAATGTAKTGAAMSMKELSLVGPAAWLQVIGVLMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBF5</accession>
    <name>B8MBF5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_116090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481811.1">
        <property type="nucleotide sequence ID" value="XM_002481766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBF5"/>
    <dbReference type="FunCoup" id="B8MBF5">
        <property type="interactions" value="422"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MBF5"/>
    <dbReference type="GeneID" id="8099636"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_116090"/>
    <dbReference type="eggNOG" id="KOG0446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008964_5_2_1"/>
    <dbReference type="InParanoid" id="B8MBF5"/>
    <dbReference type="OMA" id="IQRRKEC"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="PhylomeDB" id="B8MBF5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000473">
        <property type="entry name" value="Vacuolar sorting-associated 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF220">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="8">
        <location>
            <begin position="36"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="7">
        <location>
            <begin position="613"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="538"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED17819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="700" mass="78170" checksum="519873F2542D11BB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBW8</accession>
    <name>B8MBW8_TALSN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_121560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002482361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBW8"/>
    <dbReference type="STRING" id="441959.B8MBW8"/>
    <dbReference type="GeneID" id="8098146"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_121560"/>
    <dbReference type="eggNOG" id="ENOG502S68H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018876_0_1_1"/>
    <dbReference type="InParanoid" id="B8MBW8"/>
    <dbReference type="OrthoDB" id="2364732at2759"/>
    <dbReference type="PhylomeDB" id="B8MBW8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED18414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="495" mass="56671" checksum="9A7B11A597D771CE" modified="2009-03-03" version="1">MSTMAANLFSWVFRPNRSSPTMAEPSQRRLWCAFSDNIDNMFPIHCNINVDSIADAKEKIWVKSQPKLAQVASWELNLYSPSSPVKNIPTRENLVHLHPRKRILSDFPRSNDPDIDIIVIQPEEQQHSIATQVSNSPRLEPCQMICTRDETVSKLAEVIDSQNIVHVRGTPASGKSTLSLLLRDYYRRNGRAVFWLGIWQQNLDCLDGESPWMNFARNLRHKYPSIQRAEDFFANGNVIIIDEAQTSYGDTALWNQIIKDIRGGIGYKVKMCLFCSYGSPSTGMPYNRRDHGTPVDFAPTQRISLTPSTELGSPPIGLFYNKDEFEVVVTRLCSCDVVEKYTIDRDARNYIFSLTNGHPGAVKSIVSYIFELYRSEVKHRVIPTITEDIVIQALRDDKEVFSRLRGTVVSRSFPFGNRFTTEAANTIRKVLEDGYVLFDESLCGIRCCYENGWIHRATLVDDTEQQNSVGVLPSRLHEKYYFLSFDVFFVLYRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCB7</accession>
    <name>B8MCB7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCT-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_122920</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
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        <property type="protein sequence ID" value="EED18563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002482510.1"/>
    </dbReference>
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        <property type="interactions" value="1427"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MCB7"/>
    <dbReference type="GeneID" id="8097757"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_122920"/>
    <dbReference type="eggNOG" id="KOG0363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_6_2_1"/>
    <dbReference type="InParanoid" id="B8MCB7"/>
    <dbReference type="OMA" id="CAEMVMS"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="PhylomeDB" id="B8MCB7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03336">
        <property type="entry name" value="TCP1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="T-complex protein 1 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012716">
        <property type="entry name" value="Chap_CCT_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02341">
        <property type="entry name" value="chap_CCT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED18563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="528" mass="56727" checksum="CE1E0C52087D3C60" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8MD73</accession>
    <name>B8MD73_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PQ loop repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_114120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481590.1">
        <property type="nucleotide sequence ID" value="XM_002481545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MD73"/>
    <dbReference type="GeneID" id="8109174"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_114120"/>
    <dbReference type="eggNOG" id="KOG2913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040201_4_0_1"/>
    <dbReference type="InParanoid" id="B8MD73"/>
    <dbReference type="OMA" id="IDWNGAF"/>
    <dbReference type="OrthoDB" id="407617at2759"/>
    <dbReference type="PhylomeDB" id="B8MD73"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF37">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED17598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="288" mass="31817" checksum="D1CC75E9C8137A1F" modified="2009-03-03" version="1">MSGQDIPVAANVLGTIGTVFWCIQLVPQIWHNWRYKKTDGLPASMMLLWALCSVPFGVYMIVQNVNIPLQIQPQIFGFFGFVSWGQILHYHDGYSQLKVSLLVIGSCILAGGIEALLILTLRIPYRKGITWPDLIFGVIAAIMLASGFVPLYSEVWKRRGRVVGVNWVFLSIDSLGALFSLFALAAQGTFDILGGILYIVVFLAEVFIFLSHVIWRFRHRKLLREAKESGKTVDDLLAEKDGDPVDDNEKSNSSVTQTPVDQGVVAGEQTEAGVSASTEDKDLERGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDU7</accession>
    <name>B8MDU7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ion channel nompc, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_120720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482318.1">
        <property type="nucleotide sequence ID" value="XM_002482273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MDU7"/>
    <dbReference type="STRING" id="441959.B8MDU7"/>
    <dbReference type="GeneID" id="8100056"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_120720"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_318361_0_0_1"/>
    <dbReference type="InParanoid" id="B8MDU7"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="PhylomeDB" id="B8MDU7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="43"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="420"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="467"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="694"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="727"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED18326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="914" mass="104544" checksum="39DC94B6B58C4EF0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDY1</accession>
    <name>B8MDY1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADH-ubiquinone oxidoreductase 178 kDa subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_011670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483292.1">
        <property type="nucleotide sequence ID" value="XM_002483247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MDY1"/>
    <dbReference type="STRING" id="441959.B8MDY1"/>
    <dbReference type="GeneID" id="8105473"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_011670"/>
    <dbReference type="eggNOG" id="ENOG502S7GA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095735_1_0_1"/>
    <dbReference type="InParanoid" id="B8MDY1"/>
    <dbReference type="OMA" id="RNIQAGH"/>
    <dbReference type="OrthoDB" id="2120038at2759"/>
    <dbReference type="PhylomeDB" id="B8MDY1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034444">
        <property type="entry name" value="Nuo17.8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42100">
        <property type="entry name" value="OXIDOREDUCTASE 178 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42100:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 178 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED16058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="169" mass="19140" checksum="653409B28DA0614F" modified="2009-03-03" version="1">MFVVRRSAAPVRQLLRQQPRRFESHAAHDHHHHGPVNESFGPSFYVAVSTFAAGFLLYRISKSSEDSFISRLITKYSPDQKIFEERNAIHTVALEEAAADRHLFVGQGHQEYVDLRSNEVFNTGSPFNVAPGSQADLNAIAAHYRKYNQDLEKDRVARTKDGKVVSVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEB7</accession>
    <name>B8MEB7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydroxybutyrate dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_016230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483778.1">
        <property type="nucleotide sequence ID" value="XM_002483733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEB7"/>
    <dbReference type="STRING" id="441959.B8MEB7"/>
    <dbReference type="GeneID" id="8106396"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_016230"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="InParanoid" id="B8MEB7"/>
    <dbReference type="OMA" id="AGWHADP"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="PhylomeDB" id="B8MEB7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED16544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="291" mass="31624" checksum="1D62547FA71BEAD1" modified="2009-03-03" version="1">MEPRVWLITGCSSGFGEQFVRQNIARGDKVIATGRNAATKLAHLKDTGAAILDLDVTISEAEIFSKINEAHQIYGRIDVLVNNAGYIESGAVEDIFIDRIQRSLDTNFFGSLKVTRAVLSIMREQKSGVVGFIGSMGGWTGYPASIAYSSSKFALECLADCLQAEFAALFENCVRFIIFEPGYFRTEVFAPTKPLVLPANIPGYEPFNQVLAKGLNELYGNEAGDLVKGVARMIDVLTGTGMAAGKELPPRLPLGTDGLESIRAKCQATLKICEDWEDLITSTDVVIEAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEP0</accession>
    <name>B8MEP0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Double-strand break repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">TSTA_019830</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the MRN complex composed of two heterodimers RAD50 and MRE11 associated with a single NBS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17 19">Belongs to the MRE11/RAD32 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EED16923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484157.1">
        <property type="nucleotide sequence ID" value="XM_002484112.1"/>
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        <property type="interactions" value="1016"/>
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    <dbReference type="STRING" id="441959.B8MEP0"/>
    <dbReference type="GeneID" id="8108794"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_019830"/>
    <dbReference type="eggNOG" id="KOG2310">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009535_1_1_1"/>
    <dbReference type="InParanoid" id="B8MEP0"/>
    <dbReference type="OMA" id="ESCMFNA"/>
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    <dbReference type="PhylomeDB" id="B8MEP0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
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        <property type="term" value="F:G-quadruplex DNA binding"/>
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        <property type="term" value="F:manganese ion binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
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        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
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    </dbReference>
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        <property type="term" value="P:ascospore formation"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010791">
        <property type="term" value="P:DNA double-strand break processing involved in repair via synthesis-dependent strand annealing"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035753">
        <property type="term" value="P:maintenance of DNA trinucleotide repeats"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010780">
        <property type="term" value="P:meiotic DNA double-strand break formation involved in reciprocal meiotic recombination"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062176">
        <property type="term" value="P:R-loop processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.110:FF:000003">
        <property type="entry name" value="Double-strand break repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000011">
        <property type="entry name" value="Double-strand break repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.110">
        <property type="entry name" value="Mre11, capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003701">
        <property type="entry name" value="Mre11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038487">
        <property type="entry name" value="Mre11_capping_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00583">
        <property type="entry name" value="mre11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000882">
        <property type="entry name" value="DSB_repair_MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 17 19" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 17 19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 17 19" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 17 19" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 17 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 17 19" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 17 19" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 17 19" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14 17 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="22">
        <location>
            <begin position="290"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="531"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="568"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="601"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="635"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="678"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="723"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="741"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="758"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="18">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00064981"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01347"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED16923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="779" mass="86453" checksum="1ED98295D8ACBC58" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8MF21</accession>
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        <recommendedName>
            <fullName evidence="6">DUF1446 domain protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">TSTA_009150</name>
    </gene>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="AtuA_N"/>
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    <dbReference type="InterPro" id="IPR025496">
        <property type="entry name" value="DUF4387"/>
    </dbReference>
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        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14330">
        <property type="entry name" value="DUF4387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="2">
        <location>
            <begin position="103"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4387" evidence="3">
        <location>
            <begin position="512"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED15790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="67032" checksum="E1237805759F1494" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MF64</accession>
    <name>B8MF64_TALSN</name>
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        <submittedName>
            <fullName evidence="12">Lectin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_012700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483397.1">
        <property type="nucleotide sequence ID" value="XM_002483352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MF64"/>
    <dbReference type="STRING" id="441959.B8MF64"/>
    <dbReference type="GeneID" id="8108146"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_012700"/>
    <dbReference type="eggNOG" id="ENOG502SQAP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1111388_0_0_1"/>
    <dbReference type="InParanoid" id="B8MF64"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="PhylomeDB" id="B8MF64"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11618">
        <property type="entry name" value="ChtBD1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF2">
        <property type="entry name" value="CHITIN DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 9" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="11">
        <location>
            <begin position="7"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="11">
        <location>
            <begin position="82"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED16163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="244" mass="24737" checksum="BB37B6E21264C52D" modified="2009-03-03" version="1">MASISTDGNCGSNSKTNSTCLGSTYGDCCSAKGYCGGTSDYCGGGCQSAFGNSTAGAMNPTKASSTTASASTSTTTGTVSEDGNCGSNSAVFATCLGSEWGNCCSSHGFCGGNISYCSAGCQSEFGNCGLAAMTTNTTSNSDSSSGHLGAGAIAGISVGSAIGGLALVAVLVWLAFFRTKKKIKYSVRIEDELKPYPPSKPFVDSHELDGHGNLKHEIDGRGGYVRQELDTRMISELPAEPGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGR2</accession>
    <name>B8MGR2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">General stress response phosphoprotein phosphatase Psr1/2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_018800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484047.1">
        <property type="nucleotide sequence ID" value="XM_002484002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGR2"/>
    <dbReference type="STRING" id="441959.B8MGR2"/>
    <dbReference type="GeneID" id="8100990"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_018800"/>
    <dbReference type="eggNOG" id="KOG1605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020262_2_0_1"/>
    <dbReference type="InParanoid" id="B8MGR2"/>
    <dbReference type="OMA" id="SMVLDCT"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="PhylomeDB" id="B8MGR2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009651">
        <property type="term" value="P:response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000043">
        <property type="entry name" value="General stress response phosphoprotein phosphatase Psr1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="357"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED16813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="531" mass="58445" checksum="861BCA6BAFE39638" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGU9</accession>
    <name>B8MGU9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_014240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483563.1">
        <property type="nucleotide sequence ID" value="XM_002483518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGU9"/>
    <dbReference type="STRING" id="441959.B8MGU9"/>
    <dbReference type="GeneID" id="8107807"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_014240"/>
    <dbReference type="eggNOG" id="ENOG502R9IK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8MGU9"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="PhylomeDB" id="B8MGU9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF7">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED16329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="35899" checksum="43458F166C172DA6" modified="2009-03-03" version="1">MHVQMRPHSAAEEGTWAIHSPMRNARYIHSSNNRECTPACAVKMLNGDEDDTATAPLYTACDEEHDSAPEKEVQYYDRRRFRSIHVFTAICYLILMGMHVKLWIHSKKLESDLRTMKPDLFPSLAHSSAFRKDNRVFSLTVADTPFAGDPSLELDQAWHNLLEDSTIRVSKEDLDYYNITSLPLADGSGFASELFVTHELHCLKKIRQYIYKETYFEHVQGFARNELKRHVDHCIETLRQGIMCRGDVSLATYTYLQGSNDVTARSWGSHQCIDFESLTAWTRERAVDIFRPGVLPNPESLGPEHITAKKEPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGY0</accession>
    <name>B8MGY0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Efflux pump antibiotic resistance protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_014520</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483595.1">
        <property type="nucleotide sequence ID" value="XM_002483550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGY0"/>
    <dbReference type="GeneID" id="8107835"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_014520"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="InParanoid" id="B8MGY0"/>
    <dbReference type="OMA" id="RRRPVYM"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="PhylomeDB" id="B8MGY0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="540"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="65"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED16361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="571" mass="61645" checksum="40A1076F733B84BE" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8MH77</accession>
    <name>B8MH77_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 17">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">TSTA_019530</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 17">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 17">Cytoplasmic vesicle</location>
            <location evidence="1 17">COPII-coated vesicle membrane</location>
            <topology evidence="1 17">Peripheral membrane protein</topology>
            <orientation evidence="1 17">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 17">Endoplasmic reticulum membrane</location>
            <topology evidence="2 17">Peripheral membrane protein</topology>
            <orientation evidence="2 17">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Golgi apparatus membrane</location>
            <topology evidence="17">Peripheral membrane protein</topology>
            <orientation evidence="17">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484125.1">
        <property type="nucleotide sequence ID" value="XM_002484080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MH77"/>
    <dbReference type="FunCoup" id="B8MH77">
        <property type="interactions" value="1046"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MH77"/>
    <dbReference type="GeneID" id="8104648"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_019530"/>
    <dbReference type="eggNOG" id="KOG1986">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008658_3_0_1"/>
    <dbReference type="InParanoid" id="B8MH77"/>
    <dbReference type="OMA" id="FPPHYAE"/>
    <dbReference type="OrthoDB" id="10256289at2759"/>
    <dbReference type="PhylomeDB" id="B8MH77"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01478">
        <property type="entry name" value="Sec23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11287">
        <property type="entry name" value="Sec23_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.730:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000006">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000008">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037550">
        <property type="entry name" value="Sec23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
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        <property type="entry name" value="Znf_Sec23_Sec24"/>
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        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec23_helical"/>
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        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15 17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9 17" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 17" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="13 17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0653">Protein transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0813">Transport</keyword>
    <keyword evidence="10 17" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="19">
        <location>
            <begin position="60"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="20">
        <location>
            <begin position="127"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="22">
        <location>
            <begin position="405"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="21">
        <location>
            <begin position="523"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="18">
        <location>
            <begin position="637"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED16891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="771" mass="85826" checksum="9F8E7246FF18C879" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MH98</accession>
    <name>B8MH98_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1776-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_021350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484311.1">
        <property type="nucleotide sequence ID" value="XM_002484266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MH98"/>
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        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MH98"/>
    <dbReference type="GeneID" id="8109392"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_021350"/>
    <dbReference type="eggNOG" id="ENOG502QWSS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8MH98"/>
    <dbReference type="OMA" id="HDVRRYS"/>
    <dbReference type="OrthoDB" id="5308060at2759"/>
    <dbReference type="PhylomeDB" id="B8MH98"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013952">
        <property type="entry name" value="DUF1776_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF1">
        <property type="entry name" value="3BETA-HYDROXYSTEROID DEHYDROGENASE DHS-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08643">
        <property type="entry name" value="DUF1776"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="50490" checksum="A1B45F98517F021B" modified="2009-03-03" version="1">MTSDDQFFLDFLSSIPHDVKRYSANVADSIDRHVDHAASVIKETLTVYFPNILPVGARNVPALRQPPPKSLTDKAYDWVMRNRAWTAAVVAFFGTSAVLYLGSRTFDNRKRRARRAGNGARKEIVVIAGSPHEPMTRAIAEDLERRGFIVYVVVQSAEEEHTIQMQNRSDIRALHLDLTITPSTPSEIHPALHGLYSLISQPQYPAPGIQPHTCQLSGLIILPSLNYPTGPIPTITASSWADTINTRVLAPILITQLFIPLLTHRNHSSSIVFLYPSISSSLSAPYAGPEVAATRALSGFATSLRQELRLLQFGNGTQCNVDVVEMKLGNVDLGPHYRVPQVAGTEVLAWSQHHRSLYGPSYLASVEQRPVASAGPNAIRGSPARALHNAIFDSIAPPRKSILGRKTRRKAVVYVGRGSRSYGIIGAWIPTNLVGWMLGQGNLPHSAPDSGNSSETSWERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHA8</accession>
    <name>B8MHA8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protoplast secreted protein 2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_021440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WrbA family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484321.1">
        <property type="nucleotide sequence ID" value="XM_002484276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHA8"/>
    <dbReference type="FunCoup" id="B8MHA8">
        <property type="interactions" value="431"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MHA8"/>
    <dbReference type="GeneID" id="8109401"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_021440"/>
    <dbReference type="eggNOG" id="KOG3135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051402_0_0_1"/>
    <dbReference type="InParanoid" id="B8MHA8"/>
    <dbReference type="OMA" id="QAGGLWM"/>
    <dbReference type="OrthoDB" id="504689at2759"/>
    <dbReference type="PhylomeDB" id="B8MHA8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED17087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="198" mass="21159" checksum="7DE959991B46F184" modified="2009-03-03" version="1">MAKIAIVFYSMYGHIAKLAEAEKKGVEAAGGQADIYQIAETLPEEVLAKMGAAPKTDYPIAKAETLLEYDAILFGIPTRFGNFPAQWKTFWDRTGGIWANGGYWGKSAGVFISTGTLGGGQESTAISAMSTLVHHGFSFVPLGYKHSFGQLSNLSEIHGGSPWGAGTFAGADGSRQPTALELEIAEIQGKTFYERVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHP5</accession>
    <name>B8MHP5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_011360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
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    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002483215.1"/>
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    <dbReference type="GeneID" id="8109988"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_011360"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_001116_0_0_1"/>
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    <dbReference type="OMA" id="PNHYMGL"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
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    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
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    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007817">
        <property type="entry name" value="Isocyanide_synthase_DIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054710">
        <property type="entry name" value="Tri101-like_N"/>
    </dbReference>
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        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05141">
        <property type="entry name" value="DIT1_PvcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22664">
        <property type="entry name" value="TRI-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="996"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="396"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED16026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1614" mass="179629" checksum="9CCC01F133BEDD8B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHV9</accession>
    <name>B8MHV9_TALSN</name>
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        <submittedName>
            <fullName evidence="9">MFS multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_015270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483673.1">
        <property type="nucleotide sequence ID" value="XM_002483628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHV9"/>
    <dbReference type="STRING" id="441959.B8MHV9"/>
    <dbReference type="GeneID" id="8106269"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_015270"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_0_5_1"/>
    <dbReference type="InParanoid" id="B8MHV9"/>
    <dbReference type="OMA" id="IWQEKYV"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="PhylomeDB" id="B8MHV9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000061">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF134">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="520"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="544"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="117"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED16439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="580" mass="63515" checksum="A19C9155A487F7A7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-09-13" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHY1</accession>
    <name>B8MHY1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_015470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483695.1">
        <property type="nucleotide sequence ID" value="XM_002483650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHY1"/>
    <dbReference type="GeneID" id="8106289"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_015470"/>
    <dbReference type="HOGENOM" id="CLU_1797748_0_0_1"/>
    <dbReference type="InParanoid" id="B8MHY1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED16461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16641" checksum="1529C57543426C57" modified="2009-03-03" version="1">MPNFSYLIPDRTFVFRLQNPENVLVEVEYGRVAFQNESQLISSGTDKRRWQWRVVLKNGCFNFRNVYFGGLLQIAGSNPSGPRARFCVGEESNNGCFKLYHNDEGQLDPWSTAALRDPNSTYPILFDDVANRHICHFKFELIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8MI59</accession>
    <name>B8MI59_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_022750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484455.1">
        <property type="nucleotide sequence ID" value="XM_002484410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MI59"/>
    <dbReference type="STRING" id="441959.B8MI59"/>
    <dbReference type="GeneID" id="8107112"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_022750"/>
    <dbReference type="eggNOG" id="ENOG502SWJ5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122502_1_0_1"/>
    <dbReference type="InParanoid" id="B8MI59"/>
    <dbReference type="OMA" id="EQYFLIA"/>
    <dbReference type="OrthoDB" id="4365579at2759"/>
    <dbReference type="PhylomeDB" id="B8MI59"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED17221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="119" mass="13306" checksum="F87C963EEAEB8243" modified="2009-03-03" version="1">MFKDPKNVDQVKVKEAAQKINILGIRVLRDQLYPVKIDNTNRTAILDADGNILLEAAEALGKENNVNIAKISWLSKKDSNKAYGSMVVYITKGTDAKRLIDSNYFDIAGESAYTRIFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJP4</accession>
    <name>B8MJP4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_051800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485696.1">
        <property type="nucleotide sequence ID" value="XM_002485651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJP4"/>
    <dbReference type="GeneID" id="8103401"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_051800"/>
    <dbReference type="HOGENOM" id="CLU_094692_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJP4"/>
    <dbReference type="OrthoDB" id="4230168at2759"/>
    <dbReference type="PhylomeDB" id="B8MJP4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED15743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="160" mass="17604" checksum="AD5258ED9BEA85D2" modified="2009-03-03" version="1">MLQPEEAFEALVAEGDALKIYGEADDTIPSSPTTKSISPPSTAVKLRRYVNKIEKSIDGIKDILDEVSPGLSRHIKVVNQGSLTLAELGDLHRESFAKRQVKASGALYAKDANRLIKRRHDGDLLKIYKSHVVGVPQPMEEVASTEPQNSGFFFDTQGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8MK76</accession>
    <name>B8MK76_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_046830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485184.1">
        <property type="nucleotide sequence ID" value="XM_002485139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MK76"/>
    <dbReference type="STRING" id="441959.B8MK76"/>
    <dbReference type="GeneID" id="8108047"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_046830"/>
    <dbReference type="eggNOG" id="ENOG502SIJF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014597_0_0_1"/>
    <dbReference type="InParanoid" id="B8MK76"/>
    <dbReference type="OMA" id="PWTGIAR"/>
    <dbReference type="OrthoDB" id="4835445at2759"/>
    <dbReference type="PhylomeDB" id="B8MK76"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF11">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED15231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="690" mass="77276" checksum="BFD9EF95EDA5D0A9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MK97</accession>
    <name>B8MK97_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_047030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485205.1">
        <property type="nucleotide sequence ID" value="XM_002485160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MK97"/>
    <dbReference type="FunCoup" id="B8MK97">
        <property type="interactions" value="335"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MK97"/>
    <dbReference type="GeneID" id="8098496"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_047030"/>
    <dbReference type="eggNOG" id="KOG3311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103849_2_4_1"/>
    <dbReference type="InParanoid" id="B8MK97"/>
    <dbReference type="OMA" id="MNVKRLM"/>
    <dbReference type="OrthoDB" id="525520at2759"/>
    <dbReference type="PhylomeDB" id="B8MK97"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000015">
        <property type="entry name" value="30S ribosomal protein-like protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED15252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="119" mass="13642" checksum="E3E3231359699488" modified="2009-03-03" version="1">MVFILGVNFPERNLVKKSLETFFGIGNNVSSRLLARFHIHPTAKIGDLQNQQVLDITAALSEMKIENDLRRQILDDIKRLRDTGTYRGRRHALGLPVRGQNTRSQIKTAYKLNSAERRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKC2</accession>
    <name>B8MKC2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_047280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485230.1">
        <property type="nucleotide sequence ID" value="XM_002485185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKC2"/>
    <dbReference type="FunCoup" id="B8MKC2">
        <property type="interactions" value="1103"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MKC2"/>
    <dbReference type="MEROPS" id="T01.P02"/>
    <dbReference type="GeneID" id="8099278"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_047280"/>
    <dbReference type="eggNOG" id="KOG0180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_10_0_1"/>
    <dbReference type="InParanoid" id="B8MKC2"/>
    <dbReference type="OMA" id="CSEQLYG"/>
    <dbReference type="OrthoDB" id="204949at2759"/>
    <dbReference type="PhylomeDB" id="B8MKC2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03759">
        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000003">
        <property type="entry name" value="Proteasome subunit beta type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED15277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="206" mass="22569" checksum="D370D1C6628BF01C" modified="2009-03-03" version="1">MSSPFDINGGACVAMVGKDCVAIACDLRLGMQALTVSNNFPKIFNYAPSTYLGLTGLATDVTTVSDLFRYKVNMYRLREERHISPQTLANLVSSSLYERRFGPYFVSPVIAGINHTTGKPFICGFDSIGCIDFAKDFIVSGTASDQLFGTCEGLWEPDLGPEDLFETISQALLNAVDRDALSGWGANVYIIEKDKVTKRLLKGRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKK1</accession>
    <name>B8MKK1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_048000</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485309.1">
        <property type="nucleotide sequence ID" value="XM_002485264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKK1"/>
    <dbReference type="FunCoup" id="B8MKK1">
        <property type="interactions" value="234"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MKK1"/>
    <dbReference type="GeneID" id="8099348"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_048000"/>
    <dbReference type="eggNOG" id="KOG0605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_67_4_1"/>
    <dbReference type="InParanoid" id="B8MKK1"/>
    <dbReference type="OMA" id="KLRVDQF"/>
    <dbReference type="OrthoDB" id="18472at2759"/>
    <dbReference type="PhylomeDB" id="B8MKK1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035974">
        <property type="term" value="C:meiotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120105">
        <property type="term" value="C:mitotic actomyosin contractile ring, intermediate layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034973">
        <property type="term" value="C:Sid2-Mob1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044878">
        <property type="term" value="P:mitotic cytokinesis checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903501">
        <property type="term" value="P:positive regulation of mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903473">
        <property type="term" value="P:positive regulation of mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902846">
        <property type="term" value="P:positive regulation of mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902854">
        <property type="term" value="P:positive regulation of nuclear migration during mitotic telophase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905758">
        <property type="term" value="P:positive regulation of primary cell septum biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031028">
        <property type="term" value="P:septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05600">
        <property type="entry name" value="STKc_Sid2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000141">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000319">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000109">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF417">
        <property type="entry name" value="CELL CYCLE PROTEIN KINASE DBF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="266"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="570"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED15356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="667" mass="76115" checksum="BE8F22EB88308ECC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKL7</accession>
    <name>B8MKL7_TALSN</name>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
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        <property type="protein sequence ID" value="EED15372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485325.1">
        <property type="nucleotide sequence ID" value="XM_002485280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKL7"/>
    <dbReference type="STRING" id="441959.B8MKL7"/>
    <dbReference type="GeneID" id="8106997"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_048150"/>
    <dbReference type="eggNOG" id="KOG2088">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001871_0_0_1"/>
    <dbReference type="InParanoid" id="B8MKL7"/>
    <dbReference type="OMA" id="SWKVHKG"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="PhylomeDB" id="B8MKL7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF7">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G02710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="16">
        <location>
            <begin position="802"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="410"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
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        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="594"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="630"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EED15372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1136" mass="124175" checksum="012BBF7F1EA931E1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLX7</accession>
    <name>B8MLX7_TALSN</name>
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        <recommendedName>
            <fullName evidence="2">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">TSTA_097450</name>
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    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002485682.1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_097450"/>
    <dbReference type="eggNOG" id="ENOG502SJFZ">
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    <dbReference type="HOGENOM" id="CLU_016056_0_0_1"/>
    <dbReference type="InParanoid" id="B8MLX7"/>
    <dbReference type="OMA" id="HNTHTPW"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="PhylomeDB" id="B8MLX7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052701">
        <property type="entry name" value="GAG_Ulvan_Degrading_Sulfatases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43751">
        <property type="entry name" value="SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43751:SF3">
        <property type="entry name" value="SULFATASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="2">
        <location>
            <begin position="425"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED13489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="843" mass="95613" checksum="7EFD0CAB9CF74875" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMF0</accession>
    <name>B8MMF0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acc synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_099560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485942.1">
        <property type="nucleotide sequence ID" value="XM_002485897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMF0"/>
    <dbReference type="STRING" id="441959.B8MMF0"/>
    <dbReference type="GeneID" id="8105399"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_099560"/>
    <dbReference type="eggNOG" id="KOG0256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_1_2_1"/>
    <dbReference type="InParanoid" id="B8MMF0"/>
    <dbReference type="OMA" id="TGWYRIT"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="PhylomeDB" id="B8MMF0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF39">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="2">
        <location>
            <begin position="41"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED13704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="461" mass="52062" checksum="574AE17AEC504703" modified="2009-03-03" version="1">MANFHVSQRGAYNLKYRDNFEAQSARHQELWTPTNPNGRIFMDVAENSLLHDEVADFISRKIKIEPNDHLTYGSGPRGSLRLKKAAASFLENSFKGRDPVKSEDILVFPGLAGAIDAVTWAICDEGEGVLVCLPMYNGFNVDIPTRTGAVVVEVPFHSVDGYSGLEDVFDPDTNRRALEAAMDHAKKNGVSIRALLISQPHNPLGRCYPQETLLEMAAFCGRNGIHLISDEIYAHSVFDNPALHHWPVFTSILALDISSHIDKSMVHVLYGASKDFCVNGLRLGLLYSRNAALLGAISTNCVFSWVPHIVQDIWASMLEDHEWRKTFFAKNQSIMANNYALVIKFFKEQDIGFFHMNAATFVWVDLRRYMLPRNMRSRDAYPMLQVTDPNVGLYLEREAKVIRICSRNGVMIKPGSAYKTEELGWFRVTFTLPEHVLLEGLRRIRKSLKEIEKLGGDSTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMP4</accession>
    <name>B8MMP4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_098680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485849.1">
        <property type="nucleotide sequence ID" value="XM_002485804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMP4"/>
    <dbReference type="STRING" id="441959.B8MMP4"/>
    <dbReference type="GeneID" id="8099696"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_098680"/>
    <dbReference type="eggNOG" id="ENOG502RVTY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011409_13_0_1"/>
    <dbReference type="InParanoid" id="B8MMP4"/>
    <dbReference type="OMA" id="ESWPHRE"/>
    <dbReference type="OrthoDB" id="3172332at2759"/>
    <dbReference type="PhylomeDB" id="B8MMP4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED13611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="538" mass="61744" checksum="DA44907C3E9EE2DA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MN93</accession>
    <name>B8MN93_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_107490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486780.1">
        <property type="nucleotide sequence ID" value="XM_002486735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MN93"/>
    <dbReference type="STRING" id="441959.B8MN93"/>
    <dbReference type="GeneID" id="8106778"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_107490"/>
    <dbReference type="eggNOG" id="ENOG502SMNT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_1_1_1"/>
    <dbReference type="InParanoid" id="B8MN93"/>
    <dbReference type="OMA" id="NLITRGM"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="PhylomeDB" id="B8MN93"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED14542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="323" mass="35661" checksum="6938D3AF8E3BADC7" modified="2009-03-03" version="1">MVPHFIFGTATLGMDQTQFQNAESVTALLKTLEKLDIYRLDTGARYPPLNPGRSEQLIGEVPKELGSKFTVDTKIYTNTKTDGSGDLSSEAIEKSVNASLQRLQRVEGVNVLYVHRPDPATPLEEQIEEFNRQISQGRCKAWGISNMQPETLQAVLDLCENRGWQKPICYQGNYNLITRGMETRLLPILRARGISYNAFQPLAAGFLTGKLVNNQHAGSRFGDENPLGKSAQKLFGAAELLDAMNAFDTRVKACGLSSLEVAIRWIAHHSALSNEDGIILGASKTPQISETVELVRKGPLPAKVLDLTEELWDAVKEIRGQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPY3</accession>
    <name>B8MPY3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_053860</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486984.1">
        <property type="nucleotide sequence ID" value="XM_002486939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPY3"/>
    <dbReference type="STRING" id="441959.B8MPY3"/>
    <dbReference type="GeneID" id="8100326"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_053860"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_533211_0_0_1"/>
    <dbReference type="InParanoid" id="B8MPY3"/>
    <dbReference type="OMA" id="KEWVTHE"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="PhylomeDB" id="B8MPY3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="VerF-like"/>
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        <property type="entry name" value="XnlR_reg_dom"/>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
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    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
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        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="11">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED12873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="480" mass="53141" checksum="B8906787D8CE9234" modified="2009-03-03" version="1">MNKSCGPCAASKLRCDLARESSSCSRCLRKGLVCQRIERKKRKGNSSTNNSASGTPNSPDHEGPSFIEDHALTGLTADDDNHFLSQLADIGSLIDMSAWAWESEASSAISQQFNSLSQGIFLSKQASSDATSVPIHRLEKYARLYFSHFHQFFPILHVPTFCLQSSCPALVRAICFIGSGFDHQLETASDANLLFDSLPIILARSCVQSGGVKLSFDELQAWLLILFASMTNGGDPERAASRLLHPLLVTAVRQAGFLKIHGECTKASRNPEAWSKWITMESKKRILWGVYTVDCYQSILCGSRPLLSPTDTRASYPCDEESWNALSASSWAQLPAQDPSSCFLSSLKGLLVGQYPTSQNLTSFGMRLLILCLHSLLLEAQTSILPTGMFALEQALQTWYNIWISSQWPAYSELSARCSFLTNNLALYHLAIHFLQNGRPRLDEKAFIGESTDANNPLIAKEGAYQDEMMRCVREIMLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQ07</accession>
    <name>B8MQ07_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA biogenesis protein RRP5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ribosomal RNA-processing protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_054090</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biogenesis of rRNA. Required for the formation of 18S and 5.8S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487008.1">
        <property type="nucleotide sequence ID" value="XM_002486963.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B8MQ07">
        <property type="interactions" value="1107"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MQ07"/>
    <dbReference type="GeneID" id="8107436"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_054090"/>
    <dbReference type="eggNOG" id="KOG1070">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000845_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQ07"/>
    <dbReference type="OMA" id="GQYLRAY"/>
    <dbReference type="OrthoDB" id="412781at2759"/>
    <dbReference type="PhylomeDB" id="B8MQ07"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05702">
        <property type="entry name" value="S1_Rrp5_repeat_hs11_sc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05703">
        <property type="entry name" value="S1_Rrp5_repeat_hs12_sc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05693">
        <property type="entry name" value="S1_Rrp5_repeat_hs1_sc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05697">
        <property type="entry name" value="S1_Rrp5_repeat_hs5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05698">
        <property type="entry name" value="S1_Rrp5_repeat_hs6_sc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04461">
        <property type="entry name" value="S1_Rrp5_repeat_hs8_sc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05706">
        <property type="entry name" value="S1_Rrp5_repeat_sc10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05707">
        <property type="entry name" value="S1_Rrp5_repeat_sc11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000103">
        <property type="entry name" value="protein RRP5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000467">
        <property type="entry name" value="Putative rRNA biogenesis protein RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000155">
        <property type="entry name" value="rRNA biogenesis protein RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000159">
        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000196">
        <property type="entry name" value="rRNA biogenesis protein RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000266">
        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000278">
        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000279">
        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000367">
        <property type="entry name" value="rRNA biogenesis protein RRP5, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045209">
        <property type="entry name" value="Rrp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057301">
        <property type="entry name" value="Rrp5_OB_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057302">
        <property type="entry name" value="Rrp5_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048058">
        <property type="entry name" value="Rrp5_S1_rpt_hs11_sc8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048059">
        <property type="entry name" value="Rrp5_S1_rpt_hs1_sc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270:SF10">
        <property type="entry name" value="PROTEIN RRP5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24685">
        <property type="entry name" value="OB_RRP5_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23459">
        <property type="entry name" value="S1_RRP5"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="159"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="275"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="457"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="548"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="642"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="826"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="936"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="1044"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="1130"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="1224"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="1313"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="92"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="898"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1410"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="907"/>
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    </feature>
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            <begin position="1481"/>
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    </feature>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50126"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED12897.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1810" mass="199327" checksum="1A543C0DEDB065F1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQ89</accession>
    <name>B8MQ89_TALSN</name>
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        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_057270</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487347.1">
        <property type="nucleotide sequence ID" value="XM_002487302.1"/>
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    <dbReference type="FunCoup" id="B8MQ89">
        <property type="interactions" value="209"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MQ89"/>
    <dbReference type="GeneID" id="8109958"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_057270"/>
    <dbReference type="eggNOG" id="KOG0605">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_000709_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQ89"/>
    <dbReference type="OMA" id="HNRRFVG"/>
    <dbReference type="OrthoDB" id="162894at2759"/>
    <dbReference type="PhylomeDB" id="B8MQ89"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="STKc_Rim15_like"/>
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    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
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        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
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    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
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        <location>
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    </feature>
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    </feature>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50110"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51285"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED13236.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="2040" mass="223121" checksum="061368410224D495" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQM0</accession>
    <name>B8MQM0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_059290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487554.1">
        <property type="nucleotide sequence ID" value="XM_002487509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQM0"/>
    <dbReference type="GeneID" id="8107399"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_059290"/>
    <dbReference type="HOGENOM" id="CLU_874865_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQM0"/>
    <dbReference type="OrthoDB" id="5022096at2759"/>
    <dbReference type="PhylomeDB" id="B8MQM0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="318" mass="35094" checksum="1E7FFDB5F868815A" modified="2009-03-03" version="1">MDYGNTLIPNCVFIEVLLLSSSSSCSGKSIEKDRIWGGVGLRGFGGGLCIFISVLPLFFDSEWLAGLLTLRIEVYSLLFDTMVTLIPLGISVVYKLGIRERIVMIVLASLGCLVTASAVIEVIMVDHLSGGSLLESYKAAIFANIELHIGMIALNTAYCYYPRQRRITTNKHNSLNQYGCSLRSDFKNYSLDDVSSETKINKTSSSIYTPATVHTADTQSTMSGHDNTQTRILKSPLSPLSLLKLFLQRNQSSSSVQDIHDDTDIYTLKVYEEETESIPLKDTIQKITEYAVVSTRLSESSVYLPGNGNWFISGKVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQM7</accession>
    <name>B8MQM7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Quinone oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_059360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487561.1">
        <property type="nucleotide sequence ID" value="XM_002487516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQM7"/>
    <dbReference type="STRING" id="441959.B8MQM7"/>
    <dbReference type="GeneID" id="8107406"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_059360"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1042738_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQM7"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="PhylomeDB" id="B8MQM7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050129">
        <property type="entry name" value="Zn_alcohol_dh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401:SF2">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="2">
        <location>
            <begin position="101"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED13450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="267" mass="29390" checksum="7E8163A0BCA6200C" modified="2009-03-03" version="1">MAGVVEEVGLGVSQFAKGQNVVLIPSQSSYDSLDGYDYGENGLTDSNGTFSAPSSYLYPLPASISIRSATYLAALATAYHALLRMSLFRPLDNVLIVSSNPISLFLIRLLSLQNAYQIIVVEHHPIWKRLATQFGATHVINPRDIDISESVRLLTDDVGADVVFHIDDQYDYEVDQDIAAPPSAMLNRSRGMAYSATSAISACRTRGTIVNIAPRRMYEASKSKFRNELMMHEVQFVGFAGYDITSLRAALRLIERGDVQFEGLSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQT5</accession>
    <name>B8MQT5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_052910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486881.1">
        <property type="nucleotide sequence ID" value="XM_002486836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQT5"/>
    <dbReference type="GeneID" id="8098240"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_052910"/>
    <dbReference type="eggNOG" id="ENOG502T5P1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2706568_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQT5"/>
    <dbReference type="OMA" id="KVDESWV"/>
    <dbReference type="OrthoDB" id="4665822at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012677680" evidence="1">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="70" mass="7517" checksum="5456EE59912ED49A" modified="2009-03-03" version="1">MQIRVLLLLVAAVRAIPLATSGDVTDADEAVAYPAQVDQSWVDTTRRSVDADEAVAYPAQVDQSWVDSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MR39</accession>
    <name>B8MR39_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phenylacetyl-CoA ligase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_054460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487045.1">
        <property type="nucleotide sequence ID" value="XM_002487000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MR39"/>
    <dbReference type="STRING" id="441959.B8MR39"/>
    <dbReference type="GeneID" id="8100384"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_054460"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="InParanoid" id="B8MR39"/>
    <dbReference type="OMA" id="RDPYTCG"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="PhylomeDB" id="B8MR39"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="47"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="476"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED12934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="577" mass="64021" checksum="BB66FB4362EEC7E8" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRM6</accession>
    <name>B8MRM6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_056820</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487294.1">
        <property type="nucleotide sequence ID" value="XM_002487249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRM6"/>
    <dbReference type="STRING" id="441959.B8MRM6"/>
    <dbReference type="GeneID" id="8109913"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_056820"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8MRM6"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="PhylomeDB" id="B8MRM6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000127">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710:SF228">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="321"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="42"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="166"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="369"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="439"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED13183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="473" mass="51922" checksum="B6078C6C7B6F8DD7" modified="2009-03-03" version="1">MPERGEDVLCYHCNNVFPKDEFGLMCPRCGSDFTEIIEGSAEEQHQIGDHNSHPSSTPLAPSLSPHEHQPQSPQSLRSARYDAENPFFNHNPWSETNDDEPQRFGSPPRVSRHSYRSPDGRITFTSTTFTTGMGGRHRIPPSPDMYGGEPLLRTFGTIFQELAGAYNTQNRNGPPPDREEPWETPGASRGANFHGGSSPRNTDSPQPPPLPLGSLNEYVIFDLLRTDAAGYGFDRPGGGIHIMGTTGMGPLHPLSLLATILGGGRIGDAVYSQEELDRVISQLVDQNMNQGAPPAAESAIRSLPKRTVDKEMLGAEGMAECSICMDAVDLGSEVTELPCKHWFHGDCIEMWLKQHNTCPHCRRPIDQGESAPGTMNNPVVIPSSPPQSPRRRRSSAFGYDTNRDHNGSPYRTRRHRTSSGSSFNNNHRSPPHQAASAPPEERREQSNRDEPEPQPQSSGGGVTGWLRSHFGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B8MS34</accession>
    <name>B8MS34_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial outer membrane translocase receptor (TOM70), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_002760</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Tom70 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487866.1">
        <property type="nucleotide sequence ID" value="XM_002487821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MS34"/>
    <dbReference type="FunCoup" id="B8MS34">
        <property type="interactions" value="784"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MS34"/>
    <dbReference type="GeneID" id="8102887"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_002760"/>
    <dbReference type="eggNOG" id="KOG0547">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017516_0_1_1"/>
    <dbReference type="InParanoid" id="B8MS34"/>
    <dbReference type="OMA" id="QWRGDIE"/>
    <dbReference type="OrthoDB" id="2942533at2759"/>
    <dbReference type="PhylomeDB" id="B8MS34"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005687">
        <property type="entry name" value="Tom70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00990">
        <property type="entry name" value="3a0801s09"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="404"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="472"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="60"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED12212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="623" mass="69057" checksum="104A20D0021B9AE8" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8MS56</accession>
    <name>B8MS56_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AIG1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_000120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED11934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487588.1">
        <property type="nucleotide sequence ID" value="XM_002487543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MS56"/>
    <dbReference type="STRING" id="441959.B8MS56"/>
    <dbReference type="GeneID" id="8107440"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_000120"/>
    <dbReference type="eggNOG" id="ENOG502S5RV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047275_0_0_1"/>
    <dbReference type="InParanoid" id="B8MS56"/>
    <dbReference type="OMA" id="WKWWEIA"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="PhylomeDB" id="B8MS56"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIG1-type G" evidence="3">
        <location>
            <begin position="88"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED11934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="420" mass="47409" checksum="89EB3BA92A5ABD00" modified="2009-03-03" version="1">MEIGMSFSTPKHIPSGEPNGEQSNKEEVFSGDEQTKDTPPENGAIMSKNSISTWPFRTLFDLLKIAKGRVNQSMLNFIKQHLNGTRLIFVVGETGSGKTTLLGEITGQDLKIGHSANSGTLGYQVLPAIIHGKQYLFVDTPGFGAADLQNREVYEDIMSCVCTLGQWVTVAGIMFVHDARQQRLTQSEMTTIRWLECFCGPQFFQNVTIVQTQWDRITEDDVDQARDIAEELQTSAFKDILFPKHVRGGCVYNHGVRVGNGSDWDIFSRKRNPAERSQMAADFVQYQYERCDGVGRLQVLEELAQGWGPYETEAAKTLFNASSTPMICVLRYKAFVVDLDEEVMPKVKEEDEATAAEPSAKQQAAESSTWKWWEIAKEVAWTFWGFERTGTTKFTEYMESVTTDVWERLKGWWSGKTPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSC3</accession>
    <name>B8MSC3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_000510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED11974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487628.1">
        <property type="nucleotide sequence ID" value="XM_002487583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSC3"/>
    <dbReference type="GeneID" id="8108674"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_000510"/>
    <dbReference type="eggNOG" id="ENOG502SVBM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_935567_0_0_1"/>
    <dbReference type="InParanoid" id="B8MSC3"/>
    <dbReference type="OMA" id="VINEPEM"/>
    <dbReference type="OrthoDB" id="4159828at2759"/>
    <dbReference type="PhylomeDB" id="B8MSC3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="33725" checksum="2BD546DC2D96818F" modified="2009-03-03" version="1" fragment="single">LISDIDCPTHERGNMLDLSFALSPLALTGAKASIVSHLDATSDHQPLITTVPWDQRYKETAQKLRFDTLDHTSFLSLLASNLADIESSAAIEEDLDALAEKLTSAIQGVYRGSAKRTIIQGIGQPWWNEDCKKALHNYRLGLCSKTDFRRITRWSQRQFWREKLSTVTQMKDVFDIITVHEKRDVLVRNLLQNSAEAGDIPLDSPVPSTSLYFPDISMLQVEESVLQAGNTAPGADEIPTCILKVAWPLIKDKQSSRNQKRLISLHLDHTDQLLSYQYLAKDWSAWWHGIWHGSLYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSV0</accession>
    <name>B8MSV0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_000670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED11993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487647.1">
        <property type="nucleotide sequence ID" value="XM_002487602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSV0"/>
    <dbReference type="GeneID" id="8108690"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_000670"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_842435_0_0_1"/>
    <dbReference type="InParanoid" id="B8MSV0"/>
    <dbReference type="OrthoDB" id="5151590at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="330" mass="38241" checksum="C24366C187036D3E" modified="2009-03-03" version="1">MPPPQRRTARRELDPCMRARICELHTEAHWGYKRIHRAHPEIPISTIRNTIKKEQERINQRSMPRTGPPEKLTDENKQKLIELTIQYPHIKYMELRNAIDNKVTIRTIQGMFQKIHKRKWKCRNINLMIRRFCTPVQKQARTLVGLALLPSMLRDTDLLRCCEIGAMNLDYRGSVVPGETVVLTTVASAVYNMTVQASSIIGTNIYWSNDAPLYLRGSKVLIGIASLSLFLFLFAKVYYDPKNYYRARKWNAMSSEERDAYLAANKDSDYLHGSKGHTIFDVIGRSVDIRAEFPSTYRIWITSGRDSTSIDDSFNIEYITILETILMAYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MT23</accession>
    <name>B8MT23_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphoryl diester phosphodiesterase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_001740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487757.1">
        <property type="nucleotide sequence ID" value="XM_002487712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MT23"/>
    <dbReference type="FunCoup" id="B8MT23">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MT23"/>
    <dbReference type="GeneID" id="8098668"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_001740"/>
    <dbReference type="eggNOG" id="KOG2258">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030006_1_2_1"/>
    <dbReference type="InParanoid" id="B8MT23"/>
    <dbReference type="OMA" id="ECSWEYL"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="PhylomeDB" id="B8MT23"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08570">
        <property type="entry name" value="GDPD_YPL206cp_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43805">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43805:SF1">
        <property type="entry name" value="GP-PDE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="31"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="343" mass="39486" checksum="5D29F12E011B7DC5" modified="2009-03-03" version="1">MAESMPLLERKMEIPLPTFTFAKDTPQGKRPQAIAHRGYKARNPENTMSAFKDAVEVGAHAIETDVRLTKDGVVVLTHDPSLKRCFGQDRNVADCTWDDIKTLRSVQKPHEPVPRLKDLLDYLATPGLEDIWLLLDIKVLVPSLMQALVGDKDVQKTFDDYADDLHRSIAVTLADVKPSRPWNQRVVVGCWAAKYLPLCTKYFPGYPLTYIGFGIDYAHQFLKVPNVGINMFLMLIVGPRGQALLREVKKKRSDRSILLWTVNGESWMKWSIRQEVDGVITDDPKKYLEVCKNYNEVEKLYHSWESWKAIFYWHMRNLAFGLTFRYKHGFWVDLKKVTGNSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MT70</accession>
    <name>B8MT70_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LysR family regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_002330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487821.1">
        <property type="nucleotide sequence ID" value="XM_002487776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MT70"/>
    <dbReference type="STRING" id="441959.B8MT70"/>
    <dbReference type="GeneID" id="8102844"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_002330"/>
    <dbReference type="eggNOG" id="ENOG502S6KB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_785680_0_0_1"/>
    <dbReference type="InParanoid" id="B8MT70"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="PhylomeDB" id="B8MT70"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="39843" checksum="608FB6BBA8FC8D00" modified="2009-03-03" version="1">MRPQMIPLHYFDNTHLLRRSMVMCLTLKFDDDLDADMLRDSLIRLIKNDRWRKIGGHLHRGNRPFLHVFLVSEISKGESVVEFSKVHIDMSTRGHPLASNLHQSTCYPSAQSGVEQYRYLSGPAHRPTSFGDYLNRNLPQISLHVVRFTDGTLVSLTWPHTMSDVSGWAEIFRAWSAVLAGKRRQVPNLAGFDADFLEYFGTSSGVPRLLIEPAGRQRAYIQNATFPYVAQMPPKDIAGKWFGQTATAIRKAYKILGDSEQLMTTANLLQTPNVRSRFPVLGDRAGHHIFFVNWASARLQSAIDFRAAVTHPTNTTEAKAKSGTMDHNMRNKKGVGKPSYFHSDILNKSDLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUX7</accession>
    <name>B8MUX7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Adiponectin receptor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_109240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488501.1">
        <property type="nucleotide sequence ID" value="XM_002488456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUX7"/>
    <dbReference type="STRING" id="441959.B8MUX7"/>
    <dbReference type="GeneID" id="8107156"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109240"/>
    <dbReference type="eggNOG" id="KOG0748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023075_2_2_1"/>
    <dbReference type="InParanoid" id="B8MUX7"/>
    <dbReference type="OMA" id="WGHPAIF"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="PhylomeDB" id="B8MUX7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED11745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="222" mass="25789" checksum="50E9AD5A956E4CB2" modified="2009-03-03" version="1">MNPTNDPIYQPERTVTGQKIFGWQFDNKYILRGYRPANADYPKIFRSLTFLHNESCNVYTHLIGALLLPLVATTLLRYLAEPKFLNVSTMDYAVFGIYFWCSEVCLILSALYHLMQPHSYQVEQFWHGMDLLGIVFMTVGTLFSGIYYVFFCEASWQQLHWAMVLAMGTVTSILISNPLLKTPRWRNIKFRIPERLAPGKFDIWGSSHQIFHVAICWRCGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8MVE7</accession>
    <name>B8MVE7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_007460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962663">
        <property type="protein sequence ID" value="EED11456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488772.1">
        <property type="nucleotide sequence ID" value="XM_002488727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MVE7"/>
    <dbReference type="STRING" id="441959.B8MVE7"/>
    <dbReference type="GeneID" id="8103275"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_007460"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1409665_0_0_1"/>
    <dbReference type="InParanoid" id="B8MVE7"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="PhylomeDB" id="B8MVE7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="20830" checksum="13B4AD591303D394" modified="2009-03-03" version="1">MENGTKDRPVGLVMDSNLTLVIYLFALIGLGVPTVLLSTRLSAEAVRHLVQKTRTSTILVPARLDGTAGEALSSWDTNDSPPPSKYYPAAYRNFLTEEASSSTAFSQNNVSRKPFCLPEVGTIFTGPSITQLLRSSGAKSLLTVPSILEEIALLPDNEEIHALQQLHFIAFGGRLPKETIGDKLTAAGEHLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8LSY5</accession>
    <name>B8LSY5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase, 2OG-Fe(II) oxygenase family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_064480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340368.1">
        <property type="nucleotide sequence ID" value="XM_002340327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LSY5"/>
    <dbReference type="STRING" id="441959.B8LSY5"/>
    <dbReference type="GeneID" id="8100225"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_064480"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_4_0_1"/>
    <dbReference type="InParanoid" id="B8LSY5"/>
    <dbReference type="OMA" id="RDRNEFY"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="PhylomeDB" id="B8LSY5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000045">
        <property type="entry name" value="Oxidoreductase, 2OG-Fe(II) oxygenase family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="185"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED22981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="355" mass="40239" checksum="C7CEEB17EBE4EAB8" modified="2009-03-03" version="1">MDHENLDSLPPFPDDVPTILLDRLSLTKLLRYDSDEYRKFCRACENIGFFYLDLRNEGQGDSILSDADELFKISEQLFALDFEEKSKYDHSKKRSYYGYKPLGAGQVDEKGNLDSVEFYNIAKDDLFGIMEPLPQPDIIQNNRYKLKTFVTNAHAIVRLVLDLLNEHLQLPPSTLANMHCIDQHSGDQIRMTRSPPQPMNDGVPRLAGHTDFGSITVLFNRLGGLQVLPPGPDAEWKWVKPLPGHCIINLGDSLVKFTNGLLRSNIHRVISSPGEQARSTRYSLVYFSRPEDNVLLKRLEGSAVIPPLPEGVVEEDVSSKDWVIRRALANRTNLHDKVNMESALGTEKISRRIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8LT19</accession>
    <name>B8LT19_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_069470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340914.1">
        <property type="nucleotide sequence ID" value="XM_002340873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LT19"/>
    <dbReference type="STRING" id="441959.B8LT19"/>
    <dbReference type="GeneID" id="8107366"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_069470"/>
    <dbReference type="eggNOG" id="KOG0742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004471_4_7_1"/>
    <dbReference type="InParanoid" id="B8LT19"/>
    <dbReference type="OMA" id="HLGKIWG"/>
    <dbReference type="OrthoDB" id="4227295at2759"/>
    <dbReference type="PhylomeDB" id="B8LT19"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF2">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="1">
        <location>
            <begin position="353"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="546" mass="62496" checksum="E1B96640153CB1AC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTA7</accession>
    <name>B8LTA7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_059790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002339868.1">
        <property type="nucleotide sequence ID" value="XM_002339827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTA7"/>
    <dbReference type="STRING" id="441959.B8LTA7"/>
    <dbReference type="GeneID" id="8102427"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_059790"/>
    <dbReference type="HOGENOM" id="CLU_1918481_0_0_1"/>
    <dbReference type="InParanoid" id="B8LTA7"/>
    <dbReference type="OrthoDB" id="4220776at2759"/>
    <dbReference type="PhylomeDB" id="B8LTA7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="132" mass="15122" checksum="EFA29F56B29E3267" modified="2009-03-03" version="1">MNLQGLRQIQQDPEVRELAAVRDKLCAQIEDMFSVVEMAKKKPIYNDYQAVKACLAATIQKKERALLKWIQKAYNLNAPVLAIQRQLNGEQSNNDNNNDNKGNIPTKTAPTRIAERRYIMECMVRDPSIFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUA8</accession>
    <name>B8LUA8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Polyketide synthase, putative</fullName>
            <ecNumber evidence="12">2.3.1.94</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_060720</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.94" evidence="12"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002339967.1">
        <property type="nucleotide sequence ID" value="XM_002339926.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LUA8"/>
    <dbReference type="GeneID" id="8108601"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_060720"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_6_3_1"/>
    <dbReference type="InParanoid" id="B8LUA8"/>
    <dbReference type="OMA" id="KDNIGHT"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="PhylomeDB" id="B8LUA8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047879">
        <property type="term" value="F:erythronolide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041068">
        <property type="entry name" value="HTH_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF21">
        <property type="entry name" value="NON-REDUCING POLYKETIDE SYNTHASE AUSA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18558">
        <property type="entry name" value="HTH_51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="401"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="1308"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="1672"/>
            <end position="1749"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="1779"/>
            <end position="1853"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1308"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1463"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1628"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1869"/>
            <end position="1895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1650"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1869"/>
            <end position="1883"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="1340"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="1528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED22580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="2635" mass="290043" checksum="24291A12B0607B66" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUF6</accession>
    <name>B8LUF6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Casein kinase II subunit beta</fullName>
            <shortName evidence="4">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_071280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer composed of two alpha chains, one beta chain and one beta' chain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341115.1">
        <property type="nucleotide sequence ID" value="XM_002341074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUF6"/>
    <dbReference type="FunCoup" id="B8LUF6">
        <property type="interactions" value="576"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LUF6"/>
    <dbReference type="GeneID" id="8106638"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_071280"/>
    <dbReference type="eggNOG" id="KOG3092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8LUF6"/>
    <dbReference type="OrthoDB" id="2275560at2759"/>
    <dbReference type="PhylomeDB" id="B8LUF6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000004">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="349"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00062110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED23728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="364" mass="40335" checksum="DC5BF81615EA72D2" modified="2009-03-03" version="1">MSSSDGAPESWISSFCSLMGHEYFAEVSEDFIEDDFNLTGLQSQVPMYKEALEMILDVEPEDDEEEEEEEEEEEDDDDDVLGDEKTDLSMIESSAELLYGLIHQRYITSRPGIQQMLEKYEVHHFGVCPRVNCYGCKVLPVGRTDTPGQETVKLFCPSCYDIYTPPNSRFQSVDGAFFGTTFGCLFFMTFPELDVGGNRAESILSPAALAAGNTSKRSRVSSLHKSVSLTMSPTTEQPPTNQPAQINGILTSNFAPGLGFGKIYEPRIYGFRVSERAKSGPRMQWLRIKPRDINELDESAIYQATHGADEEGGYEEGDTEMGSTAATASQQSAIGMRRKAPMRKRRHLPSSTVNQTSTKNGEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUG8</accession>
    <name>B8LUG8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_071380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341128.1">
        <property type="nucleotide sequence ID" value="XM_002341087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUG8"/>
    <dbReference type="GeneID" id="8103902"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_071380"/>
    <dbReference type="HOGENOM" id="CLU_1687897_0_0_1"/>
    <dbReference type="InParanoid" id="B8LUG8"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="PhylomeDB" id="B8LUG8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED23741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="156" mass="16613" checksum="A102A4CE19F21CDA" modified="2009-03-03" version="1">MALPYGVLTDRVGRKPFVLSSTIATALSEVRPGVVCSSYVLIHVATLFRLVSLTIIAELVASPMATYTLSIEPWILYMLDVVIMLAGAACSIFVPETLDEAKAREAETASDPDDEKKIEETSQTSLLKSSVFGMTTYNHSSLSLKRGGGGGVNPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUI1</accession>
    <name>B8LUI1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RAD52 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_071510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341141.1">
        <property type="nucleotide sequence ID" value="XM_002341100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUI1"/>
    <dbReference type="FunCoup" id="B8LUI1">
        <property type="interactions" value="273"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LUI1"/>
    <dbReference type="GeneID" id="8101043"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_071510"/>
    <dbReference type="eggNOG" id="KOG4141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011431_4_0_1"/>
    <dbReference type="InParanoid" id="B8LUI1"/>
    <dbReference type="OMA" id="NLHRHAD"/>
    <dbReference type="OrthoDB" id="206565at2759"/>
    <dbReference type="PhylomeDB" id="B8LUI1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.80:FF:000001">
        <property type="entry name" value="DNA repair protein RAD52 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004585">
        <property type="entry name" value="DNA_recomb/repair_Rad52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00607">
        <property type="entry name" value="rad52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="210"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="417"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="521"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00077224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED23754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="599" mass="64464" checksum="A6D641E152CFD37F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUM7</accession>
    <name>B8LUM7_TALSN</name>
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        <submittedName>
            <fullName evidence="3">Haloacid dehalogenase, type II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_072740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341271.1">
        <property type="nucleotide sequence ID" value="XM_002341230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUM7"/>
    <dbReference type="STRING" id="441959.B8LUM7"/>
    <dbReference type="GeneID" id="8099925"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_072740"/>
    <dbReference type="eggNOG" id="ENOG502S2CI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_3_1_1"/>
    <dbReference type="InParanoid" id="B8LUM7"/>
    <dbReference type="OMA" id="TTFWINR"/>
    <dbReference type="OrthoDB" id="3256520at2759"/>
    <dbReference type="PhylomeDB" id="B8LUM7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019120">
        <property type="term" value="F:hydrolase activity, acting on acid halide bonds, in C-halide compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02588">
        <property type="entry name" value="HAD_L2-DEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006328">
        <property type="entry name" value="2-HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01428">
        <property type="entry name" value="HAD_type_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF3">
        <property type="entry name" value="HALOACID DEHALOGENASE, TYPE II (AFU_ORTHOLOGUE AFUA_2G07750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED23884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="239" mass="26741" checksum="7A644CBE8D73C929" modified="2009-03-03" version="1">MAQSGSLIAFDLYGTLLSTESISKRLSEILGSQETGTQVAASWRKYQLEYSWRLTCMESYDDFYNITRNALRHALSEAAVRLEEDQIDQLMDEYDHLSTFPDVTPALQNLTKRPDIKTVIFSNGTKQMVSNSVFRSQDLSPHASLFTDLVTVEDVKAYKPAPAVYEHLAVSTGTQMGDIWLISANPFDIVGAGDYGLKTAWIDRNGRGWEDAAVPRLRPRIIGKSLDEVIKAILDDLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUT4</accession>
    <name>B8LUT4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome c oxidase assembly factor 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_073310</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341328.1">
        <property type="nucleotide sequence ID" value="XM_002341287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUT4"/>
    <dbReference type="FunCoup" id="B8LUT4">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LUT4"/>
    <dbReference type="GeneID" id="8105594"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_073310"/>
    <dbReference type="eggNOG" id="ENOG502S7HF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142408_0_0_1"/>
    <dbReference type="InParanoid" id="B8LUT4"/>
    <dbReference type="OMA" id="CAKAWVK"/>
    <dbReference type="OrthoDB" id="5545577at2759"/>
    <dbReference type="PhylomeDB" id="B8LUT4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.140:FF:000003">
        <property type="entry name" value="Cytochrome c oxidase assembly factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048281">
        <property type="entry name" value="COA6_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED23941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="12976" checksum="65EE7F006DBDB7E8" modified="2009-03-03" version="1">MSWFGFGSSNAGPKSAKASDGGRIAPNRSSREVCYNGRDLFFSCLDRNDILDAIKHDSEVRKKCGKEIAEFESACSKAWVKYFKEKRVMEYNRDQTIARIQKADAEKAAEEAKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>B8LV30</accession>
    <name>B8LV30_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Polyketide synthase, putative</fullName>
            <ecNumber evidence="12">2.3.1.94</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_061410</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.94" evidence="12"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340038.1">
        <property type="nucleotide sequence ID" value="XM_002339997.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LV30"/>
    <dbReference type="GeneID" id="8106644"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_061410"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_6_2_1"/>
    <dbReference type="InParanoid" id="B8LV30"/>
    <dbReference type="OMA" id="FRINTMI"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="PhylomeDB" id="B8LV30"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047879">
        <property type="term" value="F:erythronolide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041068">
        <property type="entry name" value="HTH_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050444">
        <property type="entry name" value="Polyketide_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681:SF6">
        <property type="entry name" value="POLYKETIDE SYNTHASE 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681">
        <property type="entry name" value="POLYKETIDE SYNTHASE 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18558">
        <property type="entry name" value="HTH_51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="375"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="1277"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="1649"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="1757"/>
            <end position="1831"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1277"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1437"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1625"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1724"/>
            <end position="1743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1828"/>
            <end position="1851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1633"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1726"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="1312"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="1493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED22651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="2664" mass="293150" checksum="9B1E2244355CEADB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVC4</accession>
    <name>B8LVC4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_066250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340561.1">
        <property type="nucleotide sequence ID" value="XM_002340520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVC4"/>
    <dbReference type="STRING" id="441959.B8LVC4"/>
    <dbReference type="GeneID" id="8099923"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_066250"/>
    <dbReference type="HOGENOM" id="CLU_943916_0_0_1"/>
    <dbReference type="InParanoid" id="B8LVC4"/>
    <dbReference type="OrthoDB" id="4223277at2759"/>
    <dbReference type="PhylomeDB" id="B8LVC4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="196"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="32"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="143"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED23174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="257" mass="29634" checksum="CD71AB9B9CB1CF6A" modified="2009-03-03" version="1">METQQPPTPAQIDNWHDLGFIYGVEEGIATGAPTDILLESPASPPSTIPFDEDSPPRQLPSERVPSGEEVGEAAGSPSPVIEISDDEENHHTRPRRRRRGRPDYAYRDYQDTMEHAISAPPLSKRKREDSDVVDFGSKIKRFVKDITEPYAALNEENKRLKQERDEWRKKEKQFQNQIQFLERQNEEQRRRNILKCALCHRTFNDSWKVLGCGHTLCEDCVKDIKSKGFVFEYPCPYPACKKPIQSCQDFYPNVVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVP2</accession>
    <name>B8LVP2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pru domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_075440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341559.1">
        <property type="nucleotide sequence ID" value="XM_002341518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVP2"/>
    <dbReference type="STRING" id="441959.B8LVP2"/>
    <dbReference type="GeneID" id="8106173"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_075440"/>
    <dbReference type="eggNOG" id="KOG3037">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041798_4_0_1"/>
    <dbReference type="InParanoid" id="B8LVP2"/>
    <dbReference type="OMA" id="RSPQFMQ"/>
    <dbReference type="OrthoDB" id="340431at2759"/>
    <dbReference type="PhylomeDB" id="B8LVP2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2020.20:FF:000004">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="7">
        <location>
            <begin position="2"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="147"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED24172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="398" mass="42864" checksum="92BDA51BB748163C" modified="2009-03-03" version="1">MSIAAPIITFKAGICDLDTSANPPQVKPKPTPGYIYLYSEDDLIHFCWRPRSAPITEPELDLVMVPSDGTFTPYRSTQANTHAPTNGRIYVLKFSSSSQRYLFWLQSKSQHERGDLSYFSPRDLKLGEIVNTLLQGEEVDVQQEIANLPSNNRGGDDGDDDATMEDVEGTHHTSEHHGGHGSGGAGFDATGGDIREEGEESREGGADGGRAASAAQPDASSVIQGLLNSLQGEIQPAQSRSDEYLYTTLADLLSPSSTIPMIESADDEKVDHLLSFLPPSLLLLAQNIDDIPVSDMNAETAQAVLLSLDLEQKRDILRRVLRSPQFTQSLGSLTVAIRDGGLPSISEALKIPVENGGFVRRGGVPLGSGVAVEAFVEGIHKQVTEKAHGSRGDTMETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8LW38</accession>
    <name>B8LW38_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Low affinity iron transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_074440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341453.1">
        <property type="nucleotide sequence ID" value="XM_002341412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LW38"/>
    <dbReference type="FunCoup" id="B8LW38">
        <property type="interactions" value="238"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LW38"/>
    <dbReference type="GeneID" id="8101234"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_074440"/>
    <dbReference type="eggNOG" id="ENOG502QRCK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028340_0_0_1"/>
    <dbReference type="InParanoid" id="B8LW38"/>
    <dbReference type="OMA" id="WQVVMQD"/>
    <dbReference type="OrthoDB" id="2224262at2759"/>
    <dbReference type="PhylomeDB" id="B8LW38"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007251">
        <property type="entry name" value="Iron_permease_Fet4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04120">
        <property type="entry name" value="Iron_permease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED24066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="541" mass="61361" checksum="1D042504CFC9D93F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8LW89</accession>
    <name>B8LW89_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin subunit 5, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_074950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341504.1">
        <property type="nucleotide sequence ID" value="XM_002341463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LW89"/>
    <dbReference type="FunCoup" id="B8LW89">
        <property type="interactions" value="1014"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LW89"/>
    <dbReference type="GeneID" id="8100235"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_074950"/>
    <dbReference type="eggNOG" id="KOG3048">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091867_0_0_1"/>
    <dbReference type="InParanoid" id="B8LW89"/>
    <dbReference type="OMA" id="QAKFKAC"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="PhylomeDB" id="B8LW89"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990113">
        <property type="term" value="P:RNA polymerase I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990114">
        <property type="term" value="P:RNA polymerase II core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990115">
        <property type="term" value="P:RNA polymerase III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23157">
        <property type="entry name" value="Prefoldin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000004">
        <property type="entry name" value="Probable prefoldin subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
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        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
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    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674:SF2">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED24117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="170" mass="18222" checksum="5F1A245F16631C7B" modified="2009-03-03" version="1">MPPSDTPASGSVPPGAVDVTTLSVPQLRALQSRLNSELEQLTNSHAKLRAAQSKFRDCVRTINDGVVGKKSQQAAQSADNSILVPLTSSLYVKGKLADREKVIVDVGTGFYVEKTTAKAIEFYNKKVKELEANITDLEKIVQGKSTNLKIIEDALRQKVVSGEAVTAPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWI4</accession>
    <name>B8LWI4_TALSN</name>
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        <recommendedName>
            <fullName evidence="6">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_076610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002341641.1"/>
    </dbReference>
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    <dbReference type="STRING" id="441959.B8LWI4"/>
    <dbReference type="GeneID" id="8104697"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_076610"/>
    <dbReference type="eggNOG" id="ENOG502SK6S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043314_1_0_1"/>
    <dbReference type="InParanoid" id="B8LWI4"/>
    <dbReference type="OMA" id="QYSAPYR"/>
    <dbReference type="OrthoDB" id="5425848at2759"/>
    <dbReference type="PhylomeDB" id="B8LWI4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861">
        <property type="entry name" value="GLYCOPROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861:SF10">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877264" description="GPI anchored protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED24295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="38006" checksum="0838159AF27F7A33" modified="2009-03-03" version="1">MRSFSSIPFLTLFAAITQPACSQIVTALPYDIALEQRACANPCGYYAQLCCTSSQTCITNNLGQAECSNGGGNSGSGSWQYFTTTYTQTDLSTVTSVYSSYVTTPPTATTTCAVSLGQSTCGTTCCSASETCENGVCVAGASSEEAPTGTATPALRPTSSGAETITATQSATTTVAFIAPVSTNGTTVISEADHGGGLSGGAIAGIVIGVIAGVFLLILLCACLCVRGAIDGLLALLGLRPRRRKETTYVEERISHHSHGEAPPPRRTWFGTRPSRPPRTDDNGKSGLGWLGWFAIIAGALALCLGLRRRKHEDEKSEYSYGPGSSYYYYSDYYSGSSEQSDDRQTRHTRDSRRSRSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8LX41</accession>
    <name>B8LX41_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_061790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340078.1">
        <property type="nucleotide sequence ID" value="XM_002340037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LX41"/>
    <dbReference type="STRING" id="441959.B8LX41"/>
    <dbReference type="GeneID" id="8106055"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_061790"/>
    <dbReference type="eggNOG" id="ENOG502SIP1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1305592_0_0_1"/>
    <dbReference type="InParanoid" id="B8LX41"/>
    <dbReference type="OrthoDB" id="4364447at2759"/>
    <dbReference type="PhylomeDB" id="B8LX41"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="211" mass="23521" checksum="EB215AB91725A343" modified="2009-03-03" version="1">MSSSSDDTSIVVLVTRHQDKLTRLFEQTNIDWPVVEKQLLDWGDLFLAGKRMKLIISFNYIEDSQTLAASRKATDKRGPSSATQGMLQDCEREIDAEEEATGEPVAWKQVDELVSLVKYVQSGKTLKSHEDVPGMIREQIYRAERRRHEGQKGHSRPSSESTYPPINITNVIPAQSSQYDMSSTSPSKNLNQSANTPRLGITGARDAAVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8LX86</accession>
    <name>B8LX86_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DUF221 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_062240</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340123.1">
        <property type="nucleotide sequence ID" value="XM_002340082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LX86"/>
    <dbReference type="GeneID" id="8105985"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_062240"/>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_359390_0_0_1"/>
    <dbReference type="InParanoid" id="B8LX86"/>
    <dbReference type="OMA" id="FSVTFIR"/>
    <dbReference type="OrthoDB" id="4494408at2759"/>
    <dbReference type="PhylomeDB" id="B8LX86"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF20">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="9">
        <location>
            <begin position="60"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="10">
        <location>
            <begin position="172"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="8">
        <location>
            <begin position="332"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED22736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="689" mass="78297" checksum="60CD41069D960D00" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXD4</accession>
    <name>B8LXD4_TALSN</name>
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        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_066610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340602.1">
        <property type="nucleotide sequence ID" value="XM_002340561.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B8LXD4">
        <property type="interactions" value="610"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LXD4"/>
    <dbReference type="GeneID" id="8106041"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_066610"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001650_18_4_1"/>
    <dbReference type="InParanoid" id="B8LXD4"/>
    <dbReference type="OMA" id="NDAGHMI"/>
    <dbReference type="OrthoDB" id="4501190at2759"/>
    <dbReference type="PhylomeDB" id="B8LXD4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF440">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="625"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="276"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED23215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1674" mass="191880" checksum="F05EC29E693F270A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXP8</accession>
    <name>B8LXP8_TALSN</name>
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        <submittedName>
            <fullName evidence="2">Cleavage and polyadenylation specific factor 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_079060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXP8"/>
    <dbReference type="STRING" id="441959.B8LXP8"/>
    <dbReference type="GeneID" id="8102520"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_079060"/>
    <dbReference type="eggNOG" id="KOG1689">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068704_0_0_1"/>
    <dbReference type="InParanoid" id="B8LXP8"/>
    <dbReference type="OMA" id="NDEWEIG"/>
    <dbReference type="OrthoDB" id="277288at2759"/>
    <dbReference type="PhylomeDB" id="B8LXP8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18871">
        <property type="entry name" value="NUDIX_Cfim25_Nudt21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000005">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016706">
        <property type="entry name" value="Cleav_polyA_spec_factor_su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13047">
        <property type="entry name" value="PRE-MRNA CLEAVAGE FACTOR IM, 25KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13869">
        <property type="entry name" value="NUDIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED24549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="277" mass="31482" checksum="C589AC566A97CB9E" modified="2009-03-03" version="1">MSTVTVTAMQSSKPPIIPKSFDANQPQTIRLYPLSNYTFGTKENQPEEDPSVLARLKRLEEHYEKHGMRRTCEGVLVCHEHNHPHVLMLQIANAFFKLPGDYLHHDDDEITGFKTRLNERLAPVGSQFTGEGVNEDWEVGDTLAQWWRPNFETFMYPFLPGHVTRPKECKKLYLIQLPKKKVLSVPKNMKLLAVPLFELYDNTARYGPQLSAIPHLLSRYNFEFVDENDNVVAVTPGTPHPGIDEFKTKVLAGSAGEGEDTGMEDASEMKQENDQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYM8</accession>
    <name>B8LYM8_TALSN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_068130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340773.1">
        <property type="nucleotide sequence ID" value="XM_002340732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYM8"/>
    <dbReference type="GeneID" id="8102679"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_068130"/>
    <dbReference type="eggNOG" id="ENOG502RR7Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_721943_0_0_1"/>
    <dbReference type="InParanoid" id="B8LYM8"/>
    <dbReference type="OMA" id="WIEQDAP"/>
    <dbReference type="OrthoDB" id="4502952at2759"/>
    <dbReference type="PhylomeDB" id="B8LYM8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED23386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="383" mass="43868" checksum="A2214DF6BB00FD61" modified="2009-03-03" version="1">MESGVSAALSLGAEAIKKLNGLLEDKQTAKAWYGDVYDLFTSNQWRFWNGRRINRVFVIKKEDWVPVIRKWLPHTNGECSWLHIYWAIHESRLKHNKFNKLRLYSGLLEIPYLESAMSSLSSIGSISSLPAANLDSWGLIVLALANGADVDYEDSGKGGFVASLEARNFIITIQRDNVATQMTGHLEPRDHPEPGCRVISEQKWTNLLWYGHTFEEDDPTMSWPRINEQGGPPEDLVDGKLDAALHNTVMDDARRKVLADKLRGCIRECHNAWEEVEKEIGLFDYGDAAEIDMIKENLRKKKVILCDDRKTDFALEQTPQDTCDYAHSQLDQAEKYKGKFRRGDLVKMHKEVYDTPQKYKYQITGHKHRLGIALQTDQTVKDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZ27</accession>
    <name>B8LZ27_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_083040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478034.1">
        <property type="nucleotide sequence ID" value="XM_002477989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZ27"/>
    <dbReference type="STRING" id="441959.B8LZ27"/>
    <dbReference type="GeneID" id="8105182"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_083040"/>
    <dbReference type="HOGENOM" id="CLU_1185711_0_0_1"/>
    <dbReference type="InParanoid" id="B8LZ27"/>
    <dbReference type="OrthoDB" id="4221240at2759"/>
    <dbReference type="PhylomeDB" id="B8LZ27"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED21071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="234" mass="26457" checksum="4FB15CF993C921CD" modified="2009-03-03" version="1">MARLGVSHWQGKTTFQKHLQKEVGFDCLVLDEITKFSTFGHDVINLLYKFCAHRAPMGHIHAHSEEYQSWLNSIEHKLLDIRANLKHEEAETGSTTTQSESILVKELFILAVLLYIERTSNGTSDRPTIKNTEWTCAAFDIFSRIDSCNKPFAYVVFGCEARTDQDRTIILDVLDRTIESKANGLLHPLRDVMIKTWVHDDLKATVTLTEMSAEALCSSSCLILSTSHSVKCLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8M075</accession>
    <name>B8M075_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)</fullName>
            <ecNumber evidence="3">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_084040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="3"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478135.1">
        <property type="nucleotide sequence ID" value="XM_002478090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M075"/>
    <dbReference type="STRING" id="441959.B8M075"/>
    <dbReference type="GeneID" id="8101497"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_084040"/>
    <dbReference type="eggNOG" id="KOG2653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024540_4_0_1"/>
    <dbReference type="InParanoid" id="B8M075"/>
    <dbReference type="OMA" id="FMFSITH"/>
    <dbReference type="OrthoDB" id="434986at2759"/>
    <dbReference type="PhylomeDB" id="B8M075"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000634">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="8">
        <location>
            <begin position="222"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="519"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED21172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="543" mass="60169" checksum="5A132F2B3E8531BA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0B2</accession>
    <name>B8M0B2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_084400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478172.1">
        <property type="nucleotide sequence ID" value="XM_002478127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0B2"/>
    <dbReference type="GeneID" id="8101533"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_084400"/>
    <dbReference type="eggNOG" id="ENOG502RX0W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1273017_0_0_1"/>
    <dbReference type="InParanoid" id="B8M0B2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED21209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="217" mass="25035" checksum="7619A336D35BDE3C" modified="2009-03-03" version="1">MYSYAEYMAESEEIQVHFEGNNRPPYMMMYNNLAEICAEQYRIIDQSLDAITLASVINHMPKLKAIDITFRSPAPQWLRPLLYRGLILDNEGSFRYHLKTILPALNALGGHTLKFRNLQLPKSFLRRYPHFEHISKSIPHVIRISDAIRYERADMVSSDNWICRSAFGMFLAYHTGSSTPLPVGAILHPSTDNGERGCAFQMWEPGWCVRVQRRASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0N6</accession>
    <name>B8M0N6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_086520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478382.1">
        <property type="nucleotide sequence ID" value="XM_002478337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0N6"/>
    <dbReference type="GeneID" id="8110058"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_086520"/>
    <dbReference type="HOGENOM" id="CLU_322644_0_0_1"/>
    <dbReference type="InParanoid" id="B8M0N6"/>
    <dbReference type="OMA" id="PREFVNC"/>
    <dbReference type="OrthoDB" id="4222685at2759"/>
    <dbReference type="PhylomeDB" id="B8M0N6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED21419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="858" mass="99476" checksum="B0BBEC3044DE480F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0N9</accession>
    <name>B8M0N9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosome assembly protein Noc2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_086550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478385.1">
        <property type="nucleotide sequence ID" value="XM_002478340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0N9"/>
    <dbReference type="FunCoup" id="B8M0N9">
        <property type="interactions" value="1027"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M0N9"/>
    <dbReference type="GeneID" id="8110061"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_086550"/>
    <dbReference type="eggNOG" id="KOG2256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011272_0_0_1"/>
    <dbReference type="InParanoid" id="B8M0N9"/>
    <dbReference type="OMA" id="GCLRYYL"/>
    <dbReference type="OrthoDB" id="10266662at2759"/>
    <dbReference type="PhylomeDB" id="B8M0N9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030691">
        <property type="term" value="C:Noc2p-Noc3p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687">
        <property type="entry name" value="NUCLEOLAR COMPLEX 2 AND RAD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687:SF4">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03715">
        <property type="entry name" value="Noc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="80"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="710"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="710"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="730"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED21422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="754" mass="85375" checksum="82E4A54F1A1F1788" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0X6</accession>
    <name>B8M0X6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_089950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Lipid-anchor</topology>
            <topology evidence="1 8">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478719.1">
        <property type="nucleotide sequence ID" value="XM_002478674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0X6"/>
    <dbReference type="GeneID" id="8108083"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_089950"/>
    <dbReference type="HOGENOM" id="CLU_1230630_0_0_1"/>
    <dbReference type="InParanoid" id="B8M0X6"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="PhylomeDB" id="B8M0X6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF2">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED21756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="225" mass="25100" checksum="47C33DE611583816" modified="2009-03-03" version="1">MTTYEYFVQGRKSLDIAPTFLEAPKLHAGGFSRCRQSLNYSISRRDSCREWLKIQPSFSDQRCTMTNGLPWETCHTILSGIVVAYIGDNSASNIDTLTNSNAHQCAIDAPIIKELGANAISVHYIDPAQSHDKCMQAFQDNEIYIIATWQGSEIILMGTSNQADLTPFLKGAVRDMKAYVVARQYRNIPIGYYTSDDDNWAQQMADYLVCGGSKSEAIDFLGVND</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8M116</accession>
    <name>B8M116_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box domain and ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_090350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478759.1">
        <property type="nucleotide sequence ID" value="XM_002478714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M116"/>
    <dbReference type="STRING" id="441959.B8M116"/>
    <dbReference type="GeneID" id="8108123"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_090350"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_596085_0_0_1"/>
    <dbReference type="InParanoid" id="B8M116"/>
    <dbReference type="OMA" id="FRSICHE"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="PhylomeDB" id="B8M116"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF83">
        <property type="entry name" value="SOCS BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="204"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="300"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED21796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="511" mass="57353" checksum="5D67F78D09213066" modified="2009-03-03" version="1">MISTNLHGPDNWVCLEEQSNIFHQSCPQMDPKLATLPSELIHLVAGYLRTKDLCSYAATCCRNWDILQDTCHKEAVRVAGPTYDDYRKHMATWDPLNLVQVQKLYRIWEKKSLLIDAVSTGHLNAVRSFLDHGISPNSHNIYGKRLFHLAITIFRLPKRFPYELYWMTVRWRPCHEEGMSEAYEMIKLLLSYGADPSLSDVDDPDTTPLSLAAELGMNELVCLLINSGANVRQKGVLGKVCAYCDLEVLQFALDVGGDINDVDSGGSTLLYHAAKNKDVEVIKYLLQAGLANQINTPNRKGKTPLLKAIMADKSDNVVVLAEHGADVNIVHPSTFLPALHIACGHWMSFVAVSALIDAGADLNREAAFGSRPLHAAMRGKVETVRAILQSGKPFDIAARNSILGNTALHCAIDPPWRPKSWRRDVVRMLLAAGAPKEAENYFGCTPIDMAFEHKEFEFVYWMLTRDLEFCEDDSMFDDDEKARWLHDHQTEYEELKVLGLINLEPGIYLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1T6</accession>
    <name>B8M1T6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_085450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478277.1">
        <property type="nucleotide sequence ID" value="XM_002478232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1T6"/>
    <dbReference type="STRING" id="441959.B8M1T6"/>
    <dbReference type="GeneID" id="8106151"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_085450"/>
    <dbReference type="eggNOG" id="KOG0022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_1"/>
    <dbReference type="InParanoid" id="B8M1T6"/>
    <dbReference type="OMA" id="GWSESTC"/>
    <dbReference type="OrthoDB" id="256333at2759"/>
    <dbReference type="PhylomeDB" id="B8M1T6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08231">
        <property type="entry name" value="MDR_TM0436_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050129">
        <property type="entry name" value="Zn_alcohol_dh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="15"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED21314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="370" mass="39277" checksum="800C82763D0121F6" modified="2009-03-03" version="1">MSISGTKSKLLVLTSPAKSLEIRERIVPPPSPLCINIEVLRAGVCGTDVHLWKGDQPLPGSVVLGHEGLGRVIELGAGVKTDHASNPIAVGDVIYWNPIRPCNACYHCTISQDFTACENGTFWSLAENATVWASYTQVATLLPNNSFYKVDPNVPFDAYIALGCALPTILQAIDHLGQIPGGSNVVVQGAGPVGLAAIMMAKLAGAAHIICIEGNPVRLEQAKSFGATALVDFHQEGLQTVNARKSHINDIVGIRGVNLVIECSGNAAAFEEGIELLTRSGTYLLVGTWAGSSKVQISPFDVVQKALKIIGSTYCSPSCYYRAAHLVQANYQKFPLASCVTKTYSLERAQQALEDVAAGKVVKAVIDPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2E1</accession>
    <name>B8M2E1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_088410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478568.1">
        <property type="nucleotide sequence ID" value="XM_002478523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2E1"/>
    <dbReference type="GeneID" id="8106938"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_088410"/>
    <dbReference type="HOGENOM" id="CLU_950533_0_0_1"/>
    <dbReference type="InParanoid" id="B8M2E1"/>
    <dbReference type="OMA" id="LYIQITP"/>
    <dbReference type="OrthoDB" id="6085154at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877378" evidence="1">
        <location>
            <begin position="19"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="293" mass="31944" checksum="F7677748D1AFF2D9" modified="2009-03-03" version="1">MKLLKCLVLGIVLQHASATVGFTTYKEIDEGADNSGTILYSDLFNRSSTLFLYIQITPDGAEHTDIINDFKTLAQNYGQHGVSVIPRVRYGWPNGTIATEPEESILMDDVSTFASIFTDVTGTINIPVIQAGYCQSHGSADTPEDLAIKIKIVNTLLSTSHKVALRYPSDHQALFNGSRSVTLHDDCIFDGGFNGTDGGTWPSGDRQTWIDYIVQVAGNNTFGGEGCNDAGDAMFDWSDYTALCGGEGIAAYINTLQIAYMNYDYPQPYEELIEDPSQSTCVDAIQAALESWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2S1</accession>
    <name>B8M2S1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_094220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479139.1">
        <property type="nucleotide sequence ID" value="XM_002479094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2S1"/>
    <dbReference type="STRING" id="441959.B8M2S1"/>
    <dbReference type="GeneID" id="8103750"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_094220"/>
    <dbReference type="eggNOG" id="ENOG502SJA8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033227_1_0_1"/>
    <dbReference type="InParanoid" id="B8M2S1"/>
    <dbReference type="OMA" id="FYTYIYT"/>
    <dbReference type="OrthoDB" id="2017677at2759"/>
    <dbReference type="PhylomeDB" id="B8M2S1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033922">
        <property type="term" value="F:peptidoglycan beta-N-acetylmuramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12170">
        <property type="entry name" value="Uncharacterised protein PF07075, DUF1343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008302">
        <property type="entry name" value="NamZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048503">
        <property type="entry name" value="NamZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048502">
        <property type="entry name" value="NamZ_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42915">
        <property type="entry name" value="HYPOTHETICAL 460 KDA PROTEIN IN FEUA-SIGW INTERGENIC REGION [PRECURSOR]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42915:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN BETA-N-ACETYLMURAMIDASE NAMZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20732">
        <property type="entry name" value="NamZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07075">
        <property type="entry name" value="NamZ_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016719">
        <property type="entry name" value="UCP016719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877250" evidence="1">
        <location>
            <begin position="17"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidoglycan beta-N-acetylmuramidase NamZ N-terminal" evidence="2">
        <location>
            <begin position="42"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidoglycan beta-N-acetylmuramidase NamZ C-terminal" evidence="3">
        <location>
            <begin position="254"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED22176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="430" mass="46680" checksum="ABBE91612F3D0942" modified="2009-03-03" version="1">MKGLAILSALSSVAWAKHAVKTGLDVLIQSNYTQLAGRKVIALTNPTGVTPDLDLGVDVMFNSGAVNLVGVMGPEHGFRGTAQAGGSEGTFVDPGTGLTVYDAYNVNTSTIVSYIKESGADTVLFDIQDVGARFYTYTWALYDTMVAAAVANVSFVVVDRPNPITGVNAFGPVLNESYASYVGRRPIAQAHGMTTGELASMFVGEKWIKQAANGSDLILEVIPMKGWKRSMTWKDTGLPWVMPSPNMPTPDTALIYPGACMFEGTSISEGRGTTRPFEPQLLGGSFTNGSWVEKMRSLNIPHTNFRSACFSPTTSKFQSQTVCGLQSYVFLDSTRDYEEFDSVYLGVSLLWSAKHLYTVGNNDTGFGNTTQSFHWLFNGSNTSRYDVDVLAGGPLVREGIEAGLSPDEIRSQWEADLQAFRKKRASYLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3C4</accession>
    <name>B8M3C4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">histidinol-phosphate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_095450</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="4"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479259.1">
        <property type="nucleotide sequence ID" value="XM_002479214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3C4"/>
    <dbReference type="FunCoup" id="B8M3C4">
        <property type="interactions" value="217"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M3C4"/>
    <dbReference type="GeneID" id="8105856"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_095450"/>
    <dbReference type="eggNOG" id="KOG0633">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_3_1_1"/>
    <dbReference type="InParanoid" id="B8M3C4"/>
    <dbReference type="OMA" id="NFVQFGR"/>
    <dbReference type="OrthoDB" id="2015537at2759"/>
    <dbReference type="PhylomeDB" id="B8M3C4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885:SF2">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="12">
        <location>
            <begin position="70"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED22296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="431" mass="47506" checksum="4ABD913AFA980A38" modified="2009-03-03" version="1">MASQKQAFDLSKCARPNILKLHPYRCARDDYKDDGTNILLDANENAYGPGLLLNRDGNIEGTATTSTSPQVDFLGLNRYPDPHQIDLKQLICNLRNTKVHTQKDLKPENLFVGVGSDEAIDALLRCFCVPGQDKILTCPPTYGMYAVSADVNDVGIVKVPLDVNNGFQLQPDKINEALSADDRIKIVYICSPGNPTANLIRKEDIQKVLEHPTWNGIVVVDEAYIDFAPEGSSLAEWVNEWPNLVIMQTLSKAFGLAGIRLGTAFSSPEIAVLLNSMKAPYNISSPTSAIAQAAFTPANLAVMRKNCAKIIEQRDRMLREMPKIPGVGRFLGGQASNFLLVEMLNKDGKPDNVVALATYEAMAEKKGVVVRFRGKEYGCEGCLRITVGTEEEVTRFLKELRVVLENLHSNTPIQSSKEEQEKEIEANEVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3I5</accession>
    <name>B8M3I5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_096060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479320.1">
        <property type="nucleotide sequence ID" value="XM_002479275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3I5"/>
    <dbReference type="GeneID" id="8105917"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_096060"/>
    <dbReference type="eggNOG" id="ENOG502RQVW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081029_0_0_1"/>
    <dbReference type="InParanoid" id="B8M3I5"/>
    <dbReference type="OMA" id="QVMLFFA"/>
    <dbReference type="OrthoDB" id="4160190at2759"/>
    <dbReference type="PhylomeDB" id="B8M3I5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="300" mass="34443" checksum="7879BD4711DB5E9A" modified="2009-03-03" version="1">MNTVASSQDFEDWPDWPLRDTRYMSYASTATEDSEASLLSISRFQPPPSPTTSISPTVSDKGKSSPPVDVVRVNLSPSVTISFVRKTRLFRMQYSYIDIVKELNGTLKHLVLGGSNGSHSTFLHDFTGTRLPIPHLEYPRLSEDTPHRVSFLDEQTVQTANTSFSTQLAYTFDHWDDCVRFQELLLSSKLVFIAGLAEAKSKGRGEECISQNLRLLRGRHERLTLLFFANSQRKERKRYVSVPLNCIDKIDVPKKTSKPVLLYLRPNFEILAEMKVLHFHFLDDDERKRFGEIISHYIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B8M433</accession>
    <name>B8M433_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_039710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481210.1">
        <property type="nucleotide sequence ID" value="XM_002481165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M433"/>
    <dbReference type="GeneID" id="8109309"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_039710"/>
    <dbReference type="HOGENOM" id="CLU_2741763_0_0_1"/>
    <dbReference type="InParanoid" id="B8M433"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="71" mass="8016" checksum="C0F42D09C967F0E5" modified="2009-03-03" version="1">MRKTIPGKGKTLAIGQVTADSTDSRLLFKVLRGNERAFDHFRRPTPSVRPSSPYLVSLGTLKSKQHRRPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8M443</accession>
    <name>B8M443_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_039800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481220.1">
        <property type="nucleotide sequence ID" value="XM_002481175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M443"/>
    <dbReference type="GeneID" id="8109320"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_039800"/>
    <dbReference type="eggNOG" id="ENOG502S4VJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042303_0_1_1"/>
    <dbReference type="InParanoid" id="B8M443"/>
    <dbReference type="OMA" id="IHGTHTE"/>
    <dbReference type="OrthoDB" id="203796at2759"/>
    <dbReference type="PhylomeDB" id="B8M443"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848:SF1">
        <property type="entry name" value="SUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED20786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="488" mass="55260" checksum="8093E4AC36676125" modified="2009-03-03" version="1">MGKPSSTQPVAGSSSQSVHSLQLLDHDETDLLVDADNYENPPSYDAAISNGDGNGLNHSTSTTQNTIGQSLPSARLIDTDYRLLGGRRAQSVRSSIRNAHIVTLEPAYTRYAEELASLMAQQIRLPPRPQIVITGSHTESSTNHKDNKKQTNSVTDFDFRLDLAETLLTGWEIGSITATREILPQSTWHNATVSFDYDERKTYRGTRLKTLTWKGSKANKNLPSAAGDIQSLNRNNSYRDEEEGVPPVNIDQERLIQGDKTGLFEWCSRYCTDTSPVKSFTLTRHVHNFNATAMVDYLKSQIRETNYRGQISAHMEIVNSKVTIYSPHWINKLRNNSFVFWTCIILQLWIITWPIIWLLEKKYAVIYSCWYSSHSIDDGTGAVARRMYARGRDEHTLAEFWAPAVKQAAWARRKDDEIILLEDAERLQGLTTEQILRARTNDSEAEIERRRRVDRGDGTFMDSVVGLARGVSEVRQDWNLTMGWGGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8M544</accession>
    <name>B8M544_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxysterol binding protein (Osh5), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_029270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480084.1">
        <property type="nucleotide sequence ID" value="XM_002480039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M544"/>
    <dbReference type="FunCoup" id="B8M544">
        <property type="interactions" value="92"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M544"/>
    <dbReference type="GeneID" id="8099046"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_029270"/>
    <dbReference type="eggNOG" id="KOG2210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012334_0_2_1"/>
    <dbReference type="InParanoid" id="B8M544"/>
    <dbReference type="OMA" id="SSYWTEH"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="PhylomeDB" id="B8M544"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008142">
        <property type="term" value="F:oxysterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000003">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3490:FF:000016">
        <property type="entry name" value="Oxysterol binding protein (Osh5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000010">
        <property type="entry name" value="Oxysterol-binding protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF184">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="418" mass="46789" checksum="D269D80C06B98D39" modified="2009-03-03" version="1">MATKDEASAVPASSKSSWSSFLKSIASFNGDLSSLTAPPFILSTTSLTEYSAYWCEHPALFVAPAREANPAKRALLVLKWFLSTLHQQYCSRSEKLGSEKKPLNPFLGELFLGKWIEDEEVGETRLISEQVSHHPPATAYSIVNEKHGIELQGYNAQKASFSSTIYVKQLGHAYLSLTPPGKDVNNEADREYYLITLPSLHIESLIYGTPYVELEKTTKIASSTGYISKIDFSGKGWLSGKKNTFSAVLYKESDGEKNPLYTADGQWSSNFTIRDVRAKKDIETFTITSMKTTPLTVAPLEEQDIWETRRAWRDVAQAIERGDMEATSAAKTKIEVAQRELRKKEKEEGEEWERRFFKRVNENDDQIFMRLATMLDLTQGNGAGIESDRTGGVWRFDPSRAVDASPPYHKIGGEGLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6D5</accession>
    <name>B8M6D5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_026210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479744.1">
        <property type="nucleotide sequence ID" value="XM_002479699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6D5"/>
    <dbReference type="STRING" id="441959.B8M6D5"/>
    <dbReference type="GeneID" id="8098902"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_026210"/>
    <dbReference type="eggNOG" id="ENOG502T03H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_347537_0_0_1"/>
    <dbReference type="InParanoid" id="B8M6D5"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="PhylomeDB" id="B8M6D5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF310">
        <property type="entry name" value="FATTY ALCOHOL:CAFFEOYL-COA ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="812" mass="90684" checksum="F1BE903D718E876D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6K4</accession>
    <name>B8M6K4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin-related protein RO7, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_027600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479900.1">
        <property type="nucleotide sequence ID" value="XM_002479855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6K4"/>
    <dbReference type="STRING" id="441959.B8M6K4"/>
    <dbReference type="GeneID" id="8109679"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_027600"/>
    <dbReference type="eggNOG" id="KOG0676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023246_0_0_1"/>
    <dbReference type="InParanoid" id="B8M6K4"/>
    <dbReference type="OMA" id="GDYRGWI"/>
    <dbReference type="OrthoDB" id="337660at2759"/>
    <dbReference type="PhylomeDB" id="B8M6K4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="417"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="423"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="549" mass="61457" checksum="C7A5804E6D15E8C3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8M713</accession>
    <name>B8M713_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GMP synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_034700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480667.1">
        <property type="nucleotide sequence ID" value="XM_002480622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M713"/>
    <dbReference type="FunCoup" id="B8M713">
        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M713"/>
    <dbReference type="GeneID" id="8104312"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_034700"/>
    <dbReference type="eggNOG" id="KOG3179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054974_0_2_1"/>
    <dbReference type="InParanoid" id="B8M713"/>
    <dbReference type="OMA" id="HRDIVYG"/>
    <dbReference type="OrthoDB" id="4520676at2759"/>
    <dbReference type="PhylomeDB" id="B8M713"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED20233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="23948" checksum="0952B015C9042352" modified="2009-03-03" version="1">MSSPFRIAILECDEPIGETKRKYGSFGNLFHLLFAADGVRLQRDSSREGPEIVESSYDIRLGRNYPLLGDIDAVVLRHQIIGRALGVMPVRNENGWEVAVTEIEMTSKGRRLFGLPSLALHQMHRDMLPACPANVELLGWSERCPVQVMYQKGRLLSMQGHPEYHRSIADELLERRGPIVFGEETYNEAKSRVHLPHDGAVIAAIMLEFLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7Z2</accession>
    <name>B8M7Z2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_031310</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480305.1">
        <property type="nucleotide sequence ID" value="XM_002480260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7Z2"/>
    <dbReference type="STRING" id="441959.B8M7Z2"/>
    <dbReference type="GeneID" id="8107742"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_031310"/>
    <dbReference type="eggNOG" id="KOG0592">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_44_1_1"/>
    <dbReference type="InParanoid" id="B8M7Z2"/>
    <dbReference type="OMA" id="VDTRDKH"/>
    <dbReference type="OrthoDB" id="347657at2759"/>
    <dbReference type="PhylomeDB" id="B8M7Z2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05581">
        <property type="entry name" value="STKc_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000163">
        <property type="entry name" value="3-phosphoinositide-dependent protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000128">
        <property type="entry name" value="Serine/threonine-protein kinase ksg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039046">
        <property type="entry name" value="PDPK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF163">
        <property type="entry name" value="3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="456"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="202"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="329"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="607"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="750"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="826"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="991"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="826"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="991"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1005"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED19871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1022" mass="112436" checksum="89BF2CAA208B0643" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8M3</accession>
    <name>B8M8M3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_037560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480970.1">
        <property type="nucleotide sequence ID" value="XM_002480925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8M3"/>
    <dbReference type="GeneID" id="8102132"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_037560"/>
    <dbReference type="eggNOG" id="ENOG502SRTS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_183191_0_0_1"/>
    <dbReference type="InParanoid" id="B8M8M3"/>
    <dbReference type="OMA" id="SGAFKSY"/>
    <dbReference type="OrthoDB" id="2565331at2759"/>
    <dbReference type="PhylomeDB" id="B8M8M3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="102" mass="9404" checksum="EB5A1747BD1CF752" modified="2009-03-03" version="1">MSNNQDNNNNLVSGLGDTLGQTVGGVTSTAGGLLGNVGKTVGDATSGLGNTVSGASQGLGNTASGAGKTVGGGISNATGGGSGSGEQQIGGKEQTAENPLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8Q3</accession>
    <name>B8M8Q3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSTA_037820</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Associates with polysomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481000.1">
        <property type="nucleotide sequence ID" value="XM_002480955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8Q3"/>
    <dbReference type="FunCoup" id="B8M8Q3">
        <property type="interactions" value="1205"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M8Q3"/>
    <dbReference type="GeneID" id="8102158"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_037820"/>
    <dbReference type="eggNOG" id="KOG0331">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_16_9_1"/>
    <dbReference type="InParanoid" id="B8M8Q3"/>
    <dbReference type="OMA" id="STMPKFE"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="PhylomeDB" id="B8M8Q3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002151">
        <property type="term" value="F:G-quadruplex RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:RNA helicase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:nuclear polyadenylation-dependent mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
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        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="147"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="350"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="500"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="500"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038583"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EED20566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="543" mass="59217" checksum="AC31250964E59AF8" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8T6</accession>
    <name>B8M8T6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_038100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002480988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8T6"/>
    <dbReference type="GeneID" id="8102185"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_038100"/>
    <dbReference type="HOGENOM" id="CLU_1134203_0_0_1"/>
    <dbReference type="InParanoid" id="B8M8T6"/>
    <dbReference type="OrthoDB" id="4540540at2759"/>
    <dbReference type="PhylomeDB" id="B8M8T6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF35">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 45 MEMBER 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002874921" evidence="7">
        <location>
            <begin position="18"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED20599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="245" mass="26511" checksum="DE6DB3E673BC66B5" modified="2009-03-03" version="1">MLGTLLLIASLISLAFLDRIISVPQLSSSHTIDLTLSTVFLTFAIFISVQAVQVGLRALITDRGTPTEQAECNAWAGRHTNFASVLGTAPAAMIYTNDGTNGIGRRAAFASSTTFVVHSATGTMILFATVGIIWALNCRIPYSLLGDELYESSPLAERQGLVHGVHNIMICLPQILVTTLMATTWLIAEAERDFGGVGWFFRLAGLSAFVALYFTTKVREQDHYDAVGLPEAYILDEISLSADLH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-09-07" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9K6</accession>
    <name>TROPK_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tropolone cluster transcription factor tropK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Tropolone synthesis protein K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tropK</name>
        <name evidence="3" type="synonym">tsR6</name>
        <name type="ORF">TSTA_117810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="7642" last="7647">
            <title>Genetic, molecular, and biochemical basis of fungal tropolone biosynthesis.</title>
            <authorList>
                <person name="Davison J."/>
                <person name="al Fahad A."/>
                <person name="Cai M."/>
                <person name="Song Z."/>
                <person name="Yehia S.Y."/>
                <person name="Lazarus C.M."/>
                <person name="Bailey A.M."/>
                <person name="Simpson T.J."/>
                <person name="Cox R.J."/>
            </authorList>
            <dbReference type="PubMed" id="22508998"/>
            <dbReference type="DOI" id="10.1073/pnas.1201469109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>FUNCTION</scope>
        <source>
            <strain>ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2014" name="Angew. Chem. Int. Ed. Engl." volume="53" first="7519" last="7523">
            <title>The biosynthesis and catabolism of the maleic anhydride moiety of stipitatonic acid.</title>
            <authorList>
                <person name="al Fahad A."/>
                <person name="Abood A."/>
                <person name="Simpson T.J."/>
                <person name="Cox R.J."/>
            </authorList>
            <dbReference type="PubMed" id="24863423"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>FUNCTION</scope>
        <source>
            <strain>ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis tropolone class of fungal maleic anhydrides, including stipitaldehydic, stipitatonic and stipitatic acids (PubMed:22508998, PubMed:24863423).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="BK008910">
        <property type="protein sequence ID" value="DAA64710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482001.1">
        <property type="nucleotide sequence ID" value="XM_002481956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9K6"/>
    <dbReference type="STRING" id="441959.B8M9K6"/>
    <dbReference type="GeneID" id="8105839"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_117810"/>
    <dbReference type="eggNOG" id="ENOG502SH49">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011017_3_1_1"/>
    <dbReference type="InParanoid" id="B8M9K6"/>
    <dbReference type="OrthoDB" id="3037908at2759"/>
    <dbReference type="PhylomeDB" id="B8M9K6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF3">
        <property type="entry name" value="C6 FINGER DOMAIN TRANSCRIPTION FACTOR DBAA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000437137" description="Tropolone cluster transcription factor tropK">
        <location>
            <begin position="1"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Zn(2)-C6 fungal-type" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="22508998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="24863423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="22508998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7">
        <source>
            <dbReference type="PubMed" id="24863423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED18009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="551" mass="63144" checksum="B14BC1117E8D9744" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBZ9</accession>
    <name>B8MBZ9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_121830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482437.1">
        <property type="nucleotide sequence ID" value="XM_002482392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBZ9"/>
    <dbReference type="STRING" id="441959.B8MBZ9"/>
    <dbReference type="GeneID" id="8098172"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_121830"/>
    <dbReference type="eggNOG" id="KOG0858">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051898_7_0_1"/>
    <dbReference type="InParanoid" id="B8MBZ9"/>
    <dbReference type="OMA" id="LWRCVTS"/>
    <dbReference type="OrthoDB" id="19102at2759"/>
    <dbReference type="PhylomeDB" id="B8MBZ9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="214"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED18445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="256" mass="28562" checksum="FFA6DBB91DD6003B" modified="2009-03-03" version="1">MDVFWAAPPISRTLTAFAFVESLAVHGKFMPFWRIHFSPKLIFFTFLPEPWRLITPFFLTGPGLSFLFDLYFLYTYASGLERGSPRFALPGDFTVYLVFVCTVIMITAYYCTGASIFTRGLIMALTHTWAQANRGRIVTFYVIQIKAELLPPCLLVIDIVSGGWYAAVIDMIGIFASHLYDFLTRLWPIFGGGTNYLKTPGFLHRLYGTTVREQRSRGLGPSHSSSGQTSGQSSSREDSAGSAWSMRGAGRRLGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCC2</accession>
    <name>B8MCC2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HET domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_122970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482560.1">
        <property type="nucleotide sequence ID" value="XM_002482515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCC2"/>
    <dbReference type="STRING" id="441959.B8MCC2"/>
    <dbReference type="GeneID" id="8097762"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_122970"/>
    <dbReference type="eggNOG" id="ENOG502SK6F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_785677_0_0_1"/>
    <dbReference type="InParanoid" id="B8MCC2"/>
    <dbReference type="OMA" id="NCDARAD"/>
    <dbReference type="OrthoDB" id="4227248at2759"/>
    <dbReference type="PhylomeDB" id="B8MCC2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596:SF4">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G03140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED18568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="353" mass="39784" checksum="B452523ED4C48FA3" modified="2009-03-03" version="1">MDLRYEAMGQINNNFLNSKVTLLVDRDLMEIDIDRPSLEAKEAIVATLVVCDWNVRAWTLLEGMRGCWNLHILCKDNHIISLGDTLNDVLAYSNLTLIPPCLALQHYVPTDDRPVEGEIPPAKIEQATCLLNHRHATKDRDVTLIWSLVCGSKLCKASVDFWKSTVGNFLSTGFLVFSSPRLQGEYGFSWAPSHPNLLPPTAGTPSTEQYPAYDGEDSVAGRVTEQGFKAQWLACLIGRSRALPTWLRLKFFEQDESEVPSYIYIYNKEAYTVIAPVFKKYLWVSLLLPAVRDRGASGAASPPRPFQYQGEAKGPLLVIAGSNDGNEWEWQFVHEWDTSFQLPEFVLKDLLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCI4</accession>
    <name>B8MCI4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine transaminase</fullName>
            <ecNumber evidence="4">2.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_125170</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-(phosphooxy)-L-threonine + 2-oxoglutarate = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-serine + 2-oxoglutarate = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="4"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482792.1">
        <property type="nucleotide sequence ID" value="XM_002482747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCI4"/>
    <dbReference type="FunCoup" id="B8MCI4">
        <property type="interactions" value="593"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MCI4"/>
    <dbReference type="GeneID" id="8100296"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_125170"/>
    <dbReference type="eggNOG" id="KOG2790">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034866_0_0_1"/>
    <dbReference type="InParanoid" id="B8MCI4"/>
    <dbReference type="OMA" id="AFVYFCD"/>
    <dbReference type="OrthoDB" id="1703350at2759"/>
    <dbReference type="PhylomeDB" id="B8MCI4"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000006">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003764">
        <property type="entry name" value="PRK05355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247:SF1">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="12">
        <location>
            <begin position="167"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED18800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="424" mass="46251" checksum="1F13C3159724EDCB" modified="2009-03-03" version="1">MKREDVVYFGAGPAGLPTDVLTTAASALLNYQETGLGVAEHSHRSTLAADIVNTMKADLAEFLEIPPSHDVLIMQGGGSGQFDATVYNSVLVWVETQRQKIVRANPSINEEDLIKQLQQKVQSDLRLDYLVTGSWSLKANQEAVRLLGPTHVNVATDSRKLNDGKFGKIADESTWQLSDKPAMIYLCENETVDGVEWPSFPKTLESRASDDQTLVVGDFSSTILSRRIPFDQFSIVYFGAQKNLGLPGITVVVIKKSLLSILSQGKPDLARKIGLPVPPTILDYAVAAKNNSLYNTLSIFDVFVAGQVLKKLLATFPDKVRGQEALSGKKAALLYGVLDSYPEVYKVVPDESVRSRMNLCFRVTKGGNVDEAERAFIRGATERGLLGLKGHRSVGGIRVSNYNVVDEAGAQKLATYLKDFATSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCM9</accession>
    <name>B8MCM9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_126390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482923.1">
        <property type="nucleotide sequence ID" value="XM_002482878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCM9"/>
    <dbReference type="STRING" id="441959.B8MCM9"/>
    <dbReference type="GeneID" id="8099066"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_126390"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_377305_0_0_1"/>
    <dbReference type="InParanoid" id="B8MCM9"/>
    <dbReference type="OrthoDB" id="3562262at2759"/>
    <dbReference type="PhylomeDB" id="B8MCM9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="141"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED18931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="735" mass="83351" checksum="C2E8097976E3CA24" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCT6</accession>
    <name>B8MCT6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_126960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482980.1">
        <property type="nucleotide sequence ID" value="XM_002482935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCT6"/>
    <dbReference type="GeneID" id="8099123"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_126960"/>
    <dbReference type="HOGENOM" id="CLU_1778706_0_0_1"/>
    <dbReference type="InParanoid" id="B8MCT6"/>
    <dbReference type="PhylomeDB" id="B8MCT6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED18988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="146" mass="17143" checksum="8D04FCB81D2B6843" modified="2009-03-03" version="1">MRAKLKPIVWSQDSHLSRKSVILCHYDVYIKRIKMCNQSSIRKSCTASHDTKPLSTEAMKENVWEYINPDPNWMVLESTPAKPTEPVAPKIDFSKTSEAQLLLQKYQIKSNTYKRQLSRYEKHQKCMKYICSYILDTVYIGHKPMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MD84</accession>
    <name>B8MD84_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dynein family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_114220</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481601.1">
        <property type="nucleotide sequence ID" value="XM_002481556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MD84"/>
    <dbReference type="STRING" id="441959.B8MD84"/>
    <dbReference type="GeneID" id="8109184"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_114220"/>
    <dbReference type="eggNOG" id="KOG3905">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024211_1_0_1"/>
    <dbReference type="InParanoid" id="B8MD84"/>
    <dbReference type="OMA" id="FKHNVID"/>
    <dbReference type="OrthoDB" id="27603at2759"/>
    <dbReference type="PhylomeDB" id="B8MD84"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035974">
        <property type="term" value="C:meiotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008467">
        <property type="entry name" value="Dynein1_light_intermed_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022780">
        <property type="entry name" value="Dynein_light_int_chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688:SF0">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05783">
        <property type="entry name" value="DLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
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            <begin position="1"/>
            <end position="34"/>
        </location>
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            <begin position="63"/>
            <end position="83"/>
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        </location>
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            <begin position="515"/>
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        </location>
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            <begin position="482"/>
            <end position="493"/>
        </location>
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            <begin position="524"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED17609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="534" mass="59045" checksum="8446748755D27C70" modified="2009-03-03" version="1"> </sequence>
</entry>
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    <accession>B8MDS3</accession>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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                <person name="Fedorova-Abrams N.D."/>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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    <dbReference type="Proteomes" id="UP000001745">
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF90">
        <property type="entry name" value="CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT B"/>
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    </dbReference>
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        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED18302.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1236" mass="141193" checksum="3D05C940658076E6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8ME86</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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        <name evidence="3" type="ORF">TSTA_015970</name>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
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            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="441959.B8ME86"/>
    <dbReference type="GeneID" id="8106370"/>
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    <dbReference type="HOGENOM" id="CLU_020129_1_0_1"/>
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    <dbReference type="OrthoDB" id="4227473at2759"/>
    <dbReference type="PhylomeDB" id="B8ME86"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="200"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED16513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEB8</accession>
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        <recommendedName>
            <fullName evidence="4">WD repeat-containing protein JIP5</fullName>
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        <alternativeName>
            <fullName evidence="5">WD repeat-containing protein jip5</fullName>
        </alternativeName>
    </protein>
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        <name evidence="7" type="ORF">TSTA_016240</name>
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    <organism evidence="7 8">
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR55 family.</text>
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        <property type="protein sequence ID" value="EED16545.1"/>
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        <property type="nucleotide sequence ID" value="XM_002483734.1"/>
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    <dbReference type="FunCoup" id="B8MEB8">
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    <dbReference type="STRING" id="441959.B8MEB8"/>
    <dbReference type="GeneID" id="8106397"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_016240"/>
    <dbReference type="eggNOG" id="KOG2444">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052691_0_0_1"/>
    <dbReference type="InParanoid" id="B8MEB8"/>
    <dbReference type="OMA" id="QAIHPTE"/>
    <dbReference type="OrthoDB" id="2288928at2759"/>
    <dbReference type="PhylomeDB" id="B8MEB8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <sequence length="991" mass="108281" checksum="82162E4DDF5866EB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEG4</accession>
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        <submittedName>
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        </submittedName>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED16591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="120" mass="13794" checksum="165CE96CFB8EB098" modified="2009-03-03" version="1">MANTRLQYRRRNPYNTRSNRVRIIKTPGGNLRYLHIKKKGTAPKCGDCGVKLPGVPALRPREYSQISRPRKNVSRAYGGSRCGNCVKDRIVRAFLIEEQKIVKKVLKESQEKEKAASRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEM5</accession>
    <name>B8MEM5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_019700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484142.1">
        <property type="nucleotide sequence ID" value="XM_002484097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEM5"/>
    <dbReference type="STRING" id="441959.B8MEM5"/>
    <dbReference type="GeneID" id="8104665"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_019700"/>
    <dbReference type="eggNOG" id="ENOG502SRIH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042688_0_1_1"/>
    <dbReference type="InParanoid" id="B8MEM5"/>
    <dbReference type="OMA" id="CDRRTVD"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="PhylomeDB" id="B8MEM5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="33959" checksum="251E349CCADF7C77" modified="2009-03-03" version="1">MATIDSDDSVKAKIQYLARDDQHQLVKPYHLYLDYDYDLAPTNTTADDHFVQIRNARSLGIPSRDMFFEWGFAQLRLDCPLTPEEYWYRNKVEEILYPKYKSIAQFLFPNAARVEVLEHAIRKRDPRWMSENLERHHLKTNQPSDYVHIDMTASSATKCGIKQFNIHPKDYSRFVVVNLWKPIRGPLYDFPLTLCDRRTVDYASQTTAMDVVSRNFANENTRIYFDEKHEWYYWHGLQVDEVIAFVQADSEAENRAGVPHTAFRDPRNSDNKQLRESIEARVFVYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MES6</accession>
    <name>B8MES6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DENN (AEX-3) domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_020180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484193.1">
        <property type="nucleotide sequence ID" value="XM_002484148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MES6"/>
    <dbReference type="STRING" id="441959.B8MES6"/>
    <dbReference type="GeneID" id="8108829"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_020180"/>
    <dbReference type="eggNOG" id="ENOG502QW1Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007774_0_0_1"/>
    <dbReference type="InParanoid" id="B8MES6"/>
    <dbReference type="OMA" id="IQDPDWW"/>
    <dbReference type="OrthoDB" id="6019893at2759"/>
    <dbReference type="PhylomeDB" id="B8MES6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF31">
        <property type="entry name" value="DENN (AEX-3) DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="84"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="688"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="799"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="526"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="603"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="688"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="724"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="853"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="899"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED16959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="923" mass="103748" checksum="4236988BAB7895AD" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEX4</accession>
    <name>B8MEX4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_023110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484491.1">
        <property type="nucleotide sequence ID" value="XM_002484446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEX4"/>
    <dbReference type="STRING" id="441959.B8MEX4"/>
    <dbReference type="GeneID" id="8109963"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_023110"/>
    <dbReference type="HOGENOM" id="CLU_2607636_0_0_1"/>
    <dbReference type="InParanoid" id="B8MEX4"/>
    <dbReference type="OrthoDB" id="3645574at2759"/>
    <dbReference type="PhylomeDB" id="B8MEX4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED17257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="79" mass="9108" checksum="675ABCA193CF8114" modified="2009-03-03" version="1">MYLIYISNTNKQNPYSQKAQFFALLESKHRLIQAIVAQHLGLRSANACQVAPLRDWLHGSYNVCVKILEEDLVAKDYEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFA9</accession>
    <name>B8MFA9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_013140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483442.1">
        <property type="nucleotide sequence ID" value="XM_002483397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFA9"/>
    <dbReference type="STRING" id="441959.B8MFA9"/>
    <dbReference type="GeneID" id="8108190"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_013140"/>
    <dbReference type="HOGENOM" id="CLU_2074709_0_0_1"/>
    <dbReference type="InParanoid" id="B8MFA9"/>
    <dbReference type="OMA" id="GEHIAIN"/>
    <dbReference type="OrthoDB" id="4812218at2759"/>
    <dbReference type="PhylomeDB" id="B8MFA9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="118" mass="13209" checksum="0C90E6C1C4E974B9" modified="2009-03-03" version="1">MPNPGEHIAINEVTATAEMKKSVTGETVIVFDPPYAMVLFAEGINRRNPELKFPENEPAGDWLVTYNLNKSLTTRGRAHQCHRHMPPELLEEGRRTKGGWRDGRQLLSEDGQIALGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFG3</accession>
    <name>B8MFG3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_017710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483931.1">
        <property type="nucleotide sequence ID" value="XM_002483886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFG3"/>
    <dbReference type="GeneID" id="8109028"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_017710"/>
    <dbReference type="HOGENOM" id="CLU_3070300_0_0_1"/>
    <dbReference type="InParanoid" id="B8MFG3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="53" mass="6157" checksum="4FB41F9E27194933" modified="2009-03-03" version="1">MPDYRYSRLENDSDEDERQQSFAEPPKKGKDTYRYTAGGQHTLVLIQYVSNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MG60</accession>
    <name>B8MG60_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sarcosine oxidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_010450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483161.1">
        <property type="nucleotide sequence ID" value="XM_002483116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MG60"/>
    <dbReference type="STRING" id="441959.B8MG60"/>
    <dbReference type="GeneID" id="8105684"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_010450"/>
    <dbReference type="eggNOG" id="KOG2820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_0_1_1"/>
    <dbReference type="InParanoid" id="B8MG60"/>
    <dbReference type="OMA" id="VWNPTAG"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="PhylomeDB" id="B8MG60"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF26">
        <property type="entry name" value="L-SACCHAROPINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="8"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED15927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="424" mass="47443" checksum="3E1D119C4DB716A1" modified="2009-03-03" version="1">MTVSTNSRIIIVGAGAFGTSTAYHLSQRGYKSIRVLDRHAAPSCEAASTDISKVIRSDYNEPLYCKMGIESIEAWRDWDMFKGLYHVPGWILSARSIETSKKLGVEGLEILTPQRIKEKLPLVTGKLDGWNINVWNPTAGWAKSGEALRRMLEVSERNGVEFVSGSKGYVRKLRYASDGTTCRAVITQDGTVHEADLVILAAGAWMPSLIDLQGQLTAKGHSVAHIQLTPAETKQYSTLPILDNLELGYFFPPQEDGTFKIAHSQFITNTKTDPVSGITTSIPHTFVESPTDDLPLEIEATMRRNLRQVFPELADRPFCYTRLCWDADTADRHFLITPHPTQKNLFIATAGSAHGFKFLPIIGKYIADHIEGKLDADIVHNWRWRVGEDVNTKNLAHLDPELELSDLTGWKGRREREGRLKAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGA9</accession>
    <name>B8MGA9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_013320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483463.1">
        <property type="nucleotide sequence ID" value="XM_002483418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGA9"/>
    <dbReference type="STRING" id="441959.B8MGA9"/>
    <dbReference type="GeneID" id="8108208"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_013320"/>
    <dbReference type="eggNOG" id="ENOG502QTB6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026024_0_0_1"/>
    <dbReference type="InParanoid" id="B8MGA9"/>
    <dbReference type="OMA" id="DWWGVSA"/>
    <dbReference type="OrthoDB" id="4218385at2759"/>
    <dbReference type="PhylomeDB" id="B8MGA9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="341" mass="38293" checksum="E054D14E21AD03B7" modified="2009-03-03" version="1">MYLPNFTANIQHVQRRENTMNYVLPNITLDAAGLVAIAEITAVAQRTVLTGTSIYSDSLILCPGLHRQQSAPELNRGEFPAVAAMTSGYVFRVENPATVSFLQRHGVTGHLVTLEVLPISDGKKKRFSCCMRDLTSHLFYWVSAALSPVVLSYFLYVREWWGVFCLLVLMFARLCNVFVIRRRTKDIGWKGASEPGAKGDLLILMSGDCWIRLQGAVDDLKAVTSGKWWRERTMAEDCLTAVATVLVYINTALVSNIHTFNQIILLVMFVLSAALLFLANITTRAMHMYGRKIQVKGQPKKYYRRRDMADELIAESGRKDWARRLGLIVDVDGVANTPVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGV5</accession>
    <name>B8MGV5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_014270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483570.1">
        <property type="nucleotide sequence ID" value="XM_002483525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGV5"/>
    <dbReference type="STRING" id="441959.B8MGV5"/>
    <dbReference type="GeneID" id="8107810"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_014270"/>
    <dbReference type="eggNOG" id="ENOG502S1WE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020076_1_0_1"/>
    <dbReference type="InParanoid" id="B8MGV5"/>
    <dbReference type="OMA" id="HPCWFIP"/>
    <dbReference type="OrthoDB" id="722566at2759"/>
    <dbReference type="PhylomeDB" id="B8MGV5"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045048">
        <property type="entry name" value="FBXO31/39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10706">
        <property type="entry name" value="F-BOX FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10706:SF130">
        <property type="entry name" value="F-BOX ONLY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12014">
        <property type="entry name" value="Cyclin_D1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED16336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="486" mass="56446" checksum="605562C250933462" modified="2009-03-03" version="1">MGQLTDLPDELLHDVLSLLPAVDLVSVSATCRTLYRLSQDEKLWQRLVNANIPHKIDKPGVFDTFRDLYSAHHPYWFLPRNKIWFSDGEYTGTLIISRYDNRRGVVEAFRLVAEYREETAVPWRSHPDVEIQPFNPRLRLWLDDPVIELRNPKLLHFRDRQYSPDQFRMTMVGQNTRVCSSFSLCRGNLGNAPKIKNDLLWPPVTIPGERSARRHHEHLVDEKSNTYQQIQKLCQDPERISETSFYLRKWLHFGVGQPVIPRQPVDQTYIFATLDPALYTPTKDKPFQGIWVGDYNFHKCEFLLFLQRDPGEPAPLLNNARRHLRAMIGGARIFEETNNDDNDDGIEEEEQEVALLNGRFEDAFERASPPVTQPSDEVEEFNGTRFQGRLEGIKLTGDPNIPRGEISFVAEDIGPRGLIGVSQDGEFRGARVVQSKGHIAFQHYTDDQWVNTQLFLISPDYVAQYWEPMRHISFFRRVDIDQFTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHG8</accession>
    <name>B8MHG8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">laccase</fullName>
            <ecNumber evidence="4">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSTA_022040</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="4"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484381.1">
        <property type="nucleotide sequence ID" value="XM_002484336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHG8"/>
    <dbReference type="SMR" id="B8MHG8"/>
    <dbReference type="STRING" id="441959.B8MHG8"/>
    <dbReference type="GeneID" id="8098470"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_022040"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_3_2_1"/>
    <dbReference type="InParanoid" id="B8MHG8"/>
    <dbReference type="OMA" id="QAWQGIF"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="PhylomeDB" id="B8MHG8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000038">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000046">
        <property type="entry name" value="Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF502">
        <property type="entry name" value="MULTICOPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002875173" description="laccase" evidence="13">
        <location>
            <begin position="22"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="71"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="192"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="405"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EED17147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="563" mass="62988" checksum="5021AE952B3E1BF2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHJ6</accession>
    <name>B8MHJ6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gag-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_010930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483211.1">
        <property type="nucleotide sequence ID" value="XM_002483166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHJ6"/>
    <dbReference type="GeneID" id="8109866"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_010930"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016400_0_0_1"/>
    <dbReference type="InParanoid" id="B8MHJ6"/>
    <dbReference type="OrthoDB" id="4226988at2759"/>
    <dbReference type="PhylomeDB" id="B8MHJ6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="626" mass="67126" checksum="7C76F611E125244C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHP0</accession>
    <name>B8MHP0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytoskeleton-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_011300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483255.1">
        <property type="nucleotide sequence ID" value="XM_002483210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHP0"/>
    <dbReference type="STRING" id="441959.B8MHP0"/>
    <dbReference type="GeneID" id="8109903"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_011300"/>
    <dbReference type="eggNOG" id="ENOG502SE0J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052832_0_0_1"/>
    <dbReference type="InParanoid" id="B8MHP0"/>
    <dbReference type="OMA" id="EPKTQYI"/>
    <dbReference type="OrthoDB" id="5385189at2759"/>
    <dbReference type="PhylomeDB" id="B8MHP0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877507" description="Cytoskeleton-associated protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="39229" checksum="2BA76811FB91A196" modified="2009-03-03" version="1">MALRSDNSILWLVLGLSLGFVAARRIIHDLYEIRTLTEITRPENDERMISKGTEDALKLETLQKLSESPSYELRGASLRIISERATKEPSWDLLLEDLAGKNKRRRNRAVNAIHFLFASRALSRVTLSPRLNDFSTYKAIVDCLCNFLEEHNVEYTTTESPILPRTRPPGEKKLLATLNILLVQNIPAALEAGVVSRWLSKYPFPCLRESTTTTTHGNDYRRKDVVWLMKMYWPDDTFMSSIITTLVGTREGIRQLRKYGLMGSVMEEGKDMDDHDDGGDDEDSDVWMINGESTAGTSWVPERLSFPEESYEEQVLRRRRREAMVFSEDGGPIRSDNIIQLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8MI05</accession>
    <name>B8MI05_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_022210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484401.1">
        <property type="nucleotide sequence ID" value="XM_002484356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MI05"/>
    <dbReference type="FunCoup" id="B8MI05">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MI05"/>
    <dbReference type="GeneID" id="8098487"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_022210"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="InParanoid" id="B8MI05"/>
    <dbReference type="OMA" id="DSEHIQW"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="PhylomeDB" id="B8MI05"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF7">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="85"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="246"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED17167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="544" mass="59652" checksum="ED4F6A6B65EEC871" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B8MI74</accession>
    <name>B8MI74_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_040380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484511.1">
        <property type="nucleotide sequence ID" value="XM_002484466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MI74"/>
    <dbReference type="GeneID" id="8109994"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_040380"/>
    <dbReference type="HOGENOM" id="CLU_2689489_0_0_1"/>
    <dbReference type="InParanoid" id="B8MI74"/>
    <dbReference type="OrthoDB" id="4509585at2759"/>
    <dbReference type="PhylomeDB" id="B8MI74"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED14558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="74" mass="8158" checksum="148B8AE474B118AB" modified="2009-03-03" version="1">MPFNGSGYQGYIGTFMVIPAFGKQRTECIRTEGTSTVYAAEACGIKFALERDGFQAMRTFPETKPQTGLQNVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIB9</accession>
    <name>B8MIB9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_040820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484556.1">
        <property type="nucleotide sequence ID" value="XM_002484511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIB9"/>
    <dbReference type="GeneID" id="8099890"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_040820"/>
    <dbReference type="eggNOG" id="ENOG502SIDW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_746343_0_0_1"/>
    <dbReference type="InParanoid" id="B8MIB9"/>
    <dbReference type="OrthoDB" id="5169850at2759"/>
    <dbReference type="PhylomeDB" id="B8MIB9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED14603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="371" mass="42462" checksum="BF8E6CC10CEA8ED1" modified="2009-03-03" version="1">MSIPTDLTPRFEVRKLEAKHLAVASAILSETNIFHSPMWEIAHPDNQTKRCYDVFNAVDYLVRAAIESGLTYGVFDKEWKFKRPESVATDGALYWDQTDLTATSEQLLEQIDSPLVSICLAYDGFYPLNLDNLKDFFEILPLFATMHEHFHTIDKRDPKSWEPTAPGQVIMRTGTSTRADYEGMGLMKLMAHWEMKDAAAKGFRGINMETLHPAVDHVWMNPPAPFKATRVNIFNMNELTVEKNGQRVVACPQVDVLAGRIGPWLWHGYEFLLARVLHRLQRHHVTLLVNIPVSVLFRRCIRRHQIGGAFRRPVSSAVVRRDKAGLQARHEQLQVRDARSNNRGGLNNLRANDEFIRRKHKIGFEQSTNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIQ5</accession>
    <name>B8MIQ5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fructose-2,6-bisphosphate 2-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_050050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.46" evidence="2"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485520.1">
        <property type="nucleotide sequence ID" value="XM_002485475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIQ5"/>
    <dbReference type="FunCoup" id="B8MIQ5">
        <property type="interactions" value="479"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MIQ5"/>
    <dbReference type="GeneID" id="8108769"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_050050"/>
    <dbReference type="eggNOG" id="KOG0234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006383_1_1_1"/>
    <dbReference type="InParanoid" id="B8MIQ5"/>
    <dbReference type="OMA" id="RWIQERC"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="PhylomeDB" id="B8MIQ5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000005">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000644">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF44">
        <property type="entry name" value="6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="9">
        <location>
            <begin position="16"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="239"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED15567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="455" mass="51500" checksum="5EA5115C5F294A25" modified="2009-03-03" version="1">MSSGESGRTESASKTFYASSDDTKICVVMVGLPARGKSLIAGKALRYLAWVGISARIFNVGTYRRKLSPHPLANFFDPHNPEGEKMRWAAAEAAVSDMLKWFKESNGVVGIFDATNSTKQRRAWIHKTCTEAGIETLFVESSCDDEEIIMHNILEVKTTSPDYKGQDPEVAAQDFRNRIRNYEKVYETIDDDEKSYTYVKLINVGSTVIINQIKDYLSSRLVYYIQNLHIKPRSIWLSRHGESEFNLTGKIGGDSDISTRGEAYARALPGLLKQSGVPPGAKLTIWTSTLKRTIQTARHLAAETGYDKLEWKALDELDSGVCDGLTYEEIAEKYPEDFAARDEDKYNYRYRGGESYRDVVIRLEPIIMELERSDNIIIVTHQAVLRCIYSYFHNMSQEQSPWMEVPLHTLIKLTPRAYGTEEQRFKANIPAVSTWRGKGSSAKHQDPVDGTQPNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIQ9</accession>
    <name>B8MIQ9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UbiE/COQ5 methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_050090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485524.1">
        <property type="nucleotide sequence ID" value="XM_002485479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIQ9"/>
    <dbReference type="STRING" id="441959.B8MIQ9"/>
    <dbReference type="GeneID" id="8108773"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_050090"/>
    <dbReference type="eggNOG" id="KOG1269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057148_1_0_1"/>
    <dbReference type="InParanoid" id="B8MIQ9"/>
    <dbReference type="OMA" id="LHVWAKE"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="PhylomeDB" id="B8MIQ9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF11">
        <property type="entry name" value="GERANYL DIPHOSPHATE 2-C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="257" mass="28516" checksum="589397D2285D369C" modified="2009-03-03" version="1">MSQSYTNDHSQAVLRTHSWRNAPNSASYLLPHLKPTMSILDVGCGPGSITISLAGKVPLGYVVGVENVLDPLNGARELANSEKVSNVSFQIGDIHDLPFPDDTFDIVHAHQVLQPIADPVQAFKEMRRVIKQGGIVAARECVSSTIYPESEGLTAWQQLGDRVRRAKGNHIDAGSHMHVWANEAGFLQEYTKDSDERKYWGGLMEERARSSGFATNAVREGFATQKDMEKMAVAWRDFVQDEDGWVGLLHGQILCWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIU4</accession>
    <name>B8MIU4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pentachlorophenol 4-monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_050450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485559.1">
        <property type="nucleotide sequence ID" value="XM_002485514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIU4"/>
    <dbReference type="STRING" id="441959.B8MIU4"/>
    <dbReference type="GeneID" id="8109087"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_050450"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_9_3_1"/>
    <dbReference type="InParanoid" id="B8MIU4"/>
    <dbReference type="OMA" id="IYDIAFW"/>
    <dbReference type="OrthoDB" id="5325318at2759"/>
    <dbReference type="PhylomeDB" id="B8MIU4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF4">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="11"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="399"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED15606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="603" mass="67389" checksum="780DECF82C55A67B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJ01</accession>
    <name>B8MJ01_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_051010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485616.1">
        <property type="nucleotide sequence ID" value="XM_002485571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJ01"/>
    <dbReference type="STRING" id="441959.B8MJ01"/>
    <dbReference type="GeneID" id="8109143"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_051010"/>
    <dbReference type="eggNOG" id="ENOG502SQDU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_946590_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJ01"/>
    <dbReference type="OMA" id="DDNCANA"/>
    <dbReference type="OrthoDB" id="4224364at2759"/>
    <dbReference type="PhylomeDB" id="B8MJ01"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002875226" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="32"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED15663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="29953" checksum="0B2EB987F2EC4B5A" modified="2009-03-03" version="1">MFSTTKLQRTALLLTSFIAVLSPSLSAVALAKPTCYYPDGSIAQNDMPCGNGTDVACCGAGGICLSNGLCMDVGQPNTLARSSCTDKSWNSRNCPNYCLQDTSFNHSGCSIILFSYLEGTAEYCCNNMDAINNTPICAFNYSTFQVPDSSIVPGFALLSDYTTISNASSSTSSGSNNNHVVAVGVGVGVGVGVPLALIALASIGWALRERRKSNRYGVETVASAKTSPYSDAGHQQQSYNMTPMNPNTYVQPQQTYNNQYNSAPLSEMETRGPVELDSRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJ46</accession>
    <name>B8MJ46_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF341 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_051440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485661.1">
        <property type="nucleotide sequence ID" value="XM_002485616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJ46"/>
    <dbReference type="GeneID" id="8103366"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_051440"/>
    <dbReference type="eggNOG" id="KOG2551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051938_4_0_1"/>
    <dbReference type="InParanoid" id="B8MJ46"/>
    <dbReference type="OMA" id="DKPISQA"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="PhylomeDB" id="B8MJ46"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="43"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED15708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="199" mass="22011" checksum="BF8BF196B32763C7" modified="2009-03-03" version="1">MRFLCLHGWGTNSQFVEGHLASEMFPELREVTSSTDEFFSYADIEDMDSCLRALELLDSYVTAEGPFDGVLAFSQGAIIAASYLARRRQLGQLSKKSALPFKCAIFFSAPAVYRIENGQLRAMTRDVDGEMINIPTAHIWGSNDTTINGQAISDLCASDTREIYVHEGGHEVPGARMNSAVKSSVQIIRRVISMASYEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJ62</accession>
    <name>B8MJ62_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_041290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484604.1">
        <property type="nucleotide sequence ID" value="XM_002484559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJ62"/>
    <dbReference type="GeneID" id="8109714"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_041290"/>
    <dbReference type="eggNOG" id="ENOG502R8GX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_3_4_1"/>
    <dbReference type="InParanoid" id="B8MJ62"/>
    <dbReference type="OMA" id="WATVDIA"/>
    <dbReference type="OrthoDB" id="3897607at2759"/>
    <dbReference type="PhylomeDB" id="B8MJ62"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF113">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="26"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED14651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="377" mass="42473" checksum="0C46BD4C964B96E8" modified="2009-03-03" version="1">MADDRSLVVKAVPAVFCSIAFLTVVLRCYVRLSVVKAFGLDDGAMVISMMCYIMFCGCMIGGALYGTGRRFVDLTADQRMTAMEYWWLCEIAYCFSSVFCKISICFFLLRITIRKSHIYLLYCVMILTVIGGFIFMFMMLLQCKPVSFFWARTTLDPVYQGHCISIDIIITMTYVYSALAAFCDFTVGILPIFLVGKLNMRHEAKLAVIGILSMACVASLAVIIRIPFVKTFRDPDFLYATVDIAIWSCIENGLGISAASLATLRPLLRKFRGSYNSRPESSSRMISGPNSKPRRLWNNSLPLGSIDRLPERNDLRPDKTAVILTTIRSDPRENNNLNQSRSSGEREFPVLDIHQTFEAMTTSTSALDDERVPREHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJZ2</accession>
    <name>B8MJZ2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl CoA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_042820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484762.1">
        <property type="nucleotide sequence ID" value="XM_002484717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJZ2"/>
    <dbReference type="STRING" id="441959.B8MJZ2"/>
    <dbReference type="GeneID" id="8104759"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_042820"/>
    <dbReference type="eggNOG" id="KOG0817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043304_1_0_1"/>
    <dbReference type="InParanoid" id="B8MJZ2"/>
    <dbReference type="OMA" id="WMRRKKD"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="PhylomeDB" id="B8MJZ2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF133">
        <property type="entry name" value="COA BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="ACB" evidence="4">
        <location>
            <begin position="5"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED14809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="392" mass="45919" checksum="FE964AFAC8FDA4C1" modified="2009-03-03" version="1">MSDSVDRVFVHALNTVKKIPRTGTARPPAAERLKLYGLYKQSMEGDVEGIMDRPVGDAPDVQAEREKWDAWYSQRGISRTEAKRRYITTLINTMHLYASQTAEARELVAELEFVWDQIKYNASSSTTSSSSPIQPVKTLPVVVHPAAPRRYASIDDRMTRSMPVEMEDQDEDLAIYRRRSGDSRLRVLSPVSQSDEADVVRSHRQDEESIDDDDNDDDEEEEEEEEEEEDFQEARDGTSFSSEPTPHDTPIIEENNNRTRKRRKRTQSSPQPNWRNRMEQALTKMTAEIAALREQLDSTHHHHHHNNFNYRKPSTFFRWLLSWGKWLLYQSLRQLLWHTFILSVLLLWLRVKGDRRLERKVGDVLFKIRGRVVSLLRLVPRRWPRLVHLPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJZ9</accession>
    <name>B8MJZ9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_042880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484769.1">
        <property type="nucleotide sequence ID" value="XM_002484724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJZ9"/>
    <dbReference type="GeneID" id="8104765"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_042880"/>
    <dbReference type="eggNOG" id="ENOG502RR7Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_721943_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJZ9"/>
    <dbReference type="OrthoDB" id="4502952at2759"/>
    <dbReference type="PhylomeDB" id="B8MJZ9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED14816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="333" mass="38100" checksum="9BC798FDF0FDC261" modified="2009-03-03" version="1">MESGVSAALALGAEAVVKLNKLLKDTQTAKSWYGDFYDMFTSNQLCVWNGRQINRVFVVKKEEWVPVIRKCLDDCHRWLPHSNGMLLASYLSGVLALANGANVDYEDSGKGGFVASLDARDFVITIQRDSAATQMTGHLEPRDHPETSCRVISEPKWTNLLWYGHTFEEDDPIMSWPRIDEQGGPPEDLVEEKYHFALCNIVMDDARRKLLAKKLRESIHQCHQAWEQVENENKLRGVEADEVKKIKENLRKKKVILCDERGTDYVLEQTPEDTLDYAKSQRQQADSFGERYKQRDLVGHHKRIYALTRLLTLPKILNKNLSTRSRGINVALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MK37</accession>
    <name>B8MK37_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_043290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="5">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484807.1">
        <property type="nucleotide sequence ID" value="XM_002484762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MK37"/>
    <dbReference type="FunCoup" id="B8MK37">
        <property type="interactions" value="894"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MK37"/>
    <dbReference type="GeneID" id="8104971"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_043290"/>
    <dbReference type="eggNOG" id="KOG3373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097408_1_2_1"/>
    <dbReference type="InParanoid" id="B8MK37"/>
    <dbReference type="OMA" id="KEHEWIR"/>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="PhylomeDB" id="B8MK37"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031405">
        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="65"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="4">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED14854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="170" mass="18245" checksum="7F0A7AED1A6FA843" modified="2009-03-03" version="1">MSLAALTRPLASRMLCQRLPVTVAARRSIPAFPRGTTIRSFSRSSQFEVKKYTESHEWVELDGNVATIGITEYAAKSLGDVVYVELPTADLEVAAGEPVGAVESVKSASDVLSPVSGKVIDGNAVLGDKPKTINESPEGEGWIAKIEVNDPSEVEGLMDQKAYLESVEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLN1</accession>
    <name>B8MLN1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_101340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486132.1">
        <property type="nucleotide sequence ID" value="XM_002486087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLN1"/>
    <dbReference type="GeneID" id="8101822"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_101340"/>
    <dbReference type="eggNOG" id="ENOG502S6NX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136890_0_0_1"/>
    <dbReference type="InParanoid" id="B8MLN1"/>
    <dbReference type="OMA" id="MASMITR"/>
    <dbReference type="OrthoDB" id="3141857at2759"/>
    <dbReference type="PhylomeDB" id="B8MLN1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039965">
        <property type="entry name" value="C3H7.08c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40466">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40466:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="146" mass="16230" checksum="4D6F2DD5BD7CB05A" modified="2009-03-03" version="1">MSSIASFTARRAFAARPALISRTPVRRFASSAKEEANLDKAGKRDPELYVLLGVMSGAFMLAGWFFGRKPTSVTSESNVRIGESAMPWEGESDGKVFKYQYHPHGDKSQPLRNAPSALNTVIVPNVTLPADLHEKFNKYGKEEYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLX9</accession>
    <name>B8MLX9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposable element tc3 transposase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_097470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485729.1">
        <property type="nucleotide sequence ID" value="XM_002485684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLX9"/>
    <dbReference type="STRING" id="441959.B8MLX9"/>
    <dbReference type="GeneID" id="8103445"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_097470"/>
    <dbReference type="eggNOG" id="ENOG502QUTZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033666_0_0_1"/>
    <dbReference type="InParanoid" id="B8MLX9"/>
    <dbReference type="OMA" id="NISKXSA"/>
    <dbReference type="OrthoDB" id="5379619at2759"/>
    <dbReference type="PhylomeDB" id="B8MLX9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052338">
        <property type="entry name" value="Transposase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022:SF135">
        <property type="entry name" value="SI:DKEY-77F5.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022">
        <property type="entry name" value="TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="2">
        <location>
            <begin position="77"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="3">
        <location>
            <begin position="230"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED13491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="376" mass="43349" checksum="1C310B6C01212C51" modified="2009-03-03" version="1">MAPRRRTARKELDPCMRARICELHTSARWGYKRIHKAHPEIPISTIRNTIKKEHQRVNQRSLPRSGQPSKLSSEQKENLVQLTKENPHIKFYELQESVDMRCSKTTIRRAFRNLHMRKWLQRDRPEILPQNAEKRLQWAQRYAHFTPTDWQRVIWSDESTVERGKGGQLIWTWNDPSEQLVEHDVREIRTGKSIKKMFWAAFQYNIRTSLVPLTSDGSSRGGGISATVIRQTYMDQLPELLENGDIFMQDNAPVHTAHIIRDLLQEMQVEVMIWPPYSPDLNHIENLWAIMKTIVRQDHPELENAPDNDTTLCALIQAGIEAWESIGERGGGEVRVVVSDMGGANTTGKALYVDTVIRAGPYTEICSSTINIENLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8MM92</accession>
    <name>B8MM92_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">O-methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_099010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485884.1">
        <property type="nucleotide sequence ID" value="XM_002485839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MM92"/>
    <dbReference type="GeneID" id="8103979"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_099010"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_1_3_1"/>
    <dbReference type="InParanoid" id="B8MM92"/>
    <dbReference type="OMA" id="PLQWIRT"/>
    <dbReference type="OrthoDB" id="4219326at2759"/>
    <dbReference type="PhylomeDB" id="B8MM92"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF16">
        <property type="entry name" value="O-METHYLTRANSFERASE ELCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="6">
        <location>
            <begin position="194"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED13646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="422" mass="48554" checksum="62E34BBA2AE54E84" modified="2009-03-03" version="1">MTIIKRQSLVLEKAREALKQAERLVNYLEENGHEEPNFSSTSPPHPENNEYDSIRIDLSQTAQDLMLLANGPLQWIRTFCCCHHDLAAWQVALRFKFFTIVPLDRPISVKEMATHAKMDEDRLRRVIKFLTTQRCFQELDDDKFEHTSLSAYIARNKDIEQCFAFEADEMFEASSLTATSIEKLPYNSVAEYSAFNLRFGTSPYKWYAENPERGARFASAMAGLVQSIDTTELRDRFPWGKLGNKKVVDVGGGSGHISIYLANEFPELSFVVQDVNTVMLEEGPKRADFPRVKDRVLFMQYSFYDPQPITDAGLFFLRQVIHNYPDDVCVKIFKSFIPALEKCDRGTSLLINDMVLPPPNTEPKVEEHHLRQIDIHMLNGYAAKQRTLREFQHLLKQADPRLEVIKVHGKGIMGLLEVKFQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMK3</accession>
    <name>B8MMK3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_100030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485995.1">
        <property type="nucleotide sequence ID" value="XM_002485950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMK3"/>
    <dbReference type="GeneID" id="8105446"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_100030"/>
    <dbReference type="eggNOG" id="ENOG502SA1Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092860_0_0_1"/>
    <dbReference type="InParanoid" id="B8MMK3"/>
    <dbReference type="OMA" id="SHQYIRA"/>
    <dbReference type="OrthoDB" id="5329332at2759"/>
    <dbReference type="PhylomeDB" id="B8MMK3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED13757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="277" mass="31674" checksum="32EAE5A08417AC5B" modified="2009-03-03" version="1">MVWIPRDIAARYLAETTLLNAYILTPISSTALNKLKSRFEHGAALHYNPQVEFNIQHAPDEYIGKTHSYIRAMENEANRDYPFLLIDEWATTDCAVWYIDSFAAEYELDDDGTGFAAPSTDVLHEILVKASMVAWMHNDVEISSGPSEQLIHSVYKNYRTPVNNWPEIAGCEEELRAEEDEKMCILFHARAGRCVAEPGDYEECTDDEIVHNAVARLKPEVAESNGMISDWKWFHTAKEFDLGDGTVKQFPQGSIWLDVVFDTKFDWPEYKWPKGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMN1</accession>
    <name>B8MMN1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nonribosomal peptide synthase SidD</fullName>
            <ecNumber evidence="7">5.1.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_100300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.11" evidence="7"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486023.1">
        <property type="nucleotide sequence ID" value="XM_002485978.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MMN1"/>
    <dbReference type="GeneID" id="8097914"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_100300"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_60_2_1"/>
    <dbReference type="InParanoid" id="B8MMN1"/>
    <dbReference type="OMA" id="IQYTMLY"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047462">
        <property type="term" value="F:phenylalanine racemase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000050">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000003">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056896">
        <property type="entry name" value="SIDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF3">
        <property type="entry name" value="SIDEROPHORE SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24895">
        <property type="entry name" value="SIDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="774"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1577"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED13785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="2110" mass="234767" checksum="206F9AB0D86438F3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNH0</accession>
    <name>B8MNH0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_102860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486297.1">
        <property type="nucleotide sequence ID" value="XM_002486252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNH0"/>
    <dbReference type="FunCoup" id="B8MNH0">
        <property type="interactions" value="236"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MNH0"/>
    <dbReference type="GeneID" id="8102905"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_102860"/>
    <dbReference type="eggNOG" id="ENOG502S6US">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015493_3_0_1"/>
    <dbReference type="InParanoid" id="B8MNH0"/>
    <dbReference type="OMA" id="CFYDISD"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="PhylomeDB" id="B8MNH0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED14059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="580" mass="65157" checksum="A3BB24C5209936E8" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8MP50</accession>
    <name>B8MP50_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_105010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
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</entry>
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</entry>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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        </source>
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    </dbReference>
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            <end position="23"/>
        </location>
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        <location>
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            <end position="388"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
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        <location>
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            <end position="222"/>
        </location>
    </feature>
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        <location>
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            <end position="267"/>
        </location>
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        </location>
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    </feature>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="388" mass="44087" checksum="1CF203A0B33EF190" modified="2009-03-03" version="1">MVLDDSSSSDSTTLDPSTNTDTWDSPDLSSRYASVFPLKINRQYLQRPNPFLLWVGFAGPWNWERTVMYRLSAQLETVKGLLRRDPTQPEVDALVEYTSREVNTRRIGLPIGVTAGSVHAYYTLRKKLSIPSELSFLEGLKVAWRLSPVLERRQAALQAGLRFGVWVIFTLGNFIALSSDPRLAEFRDAVRRYAEARMQRMEGYKEKTKQRREQRDAARHEGTTVSAEEPEENYKAESTEGTTDDQSHSSPSPSYQTPPRSYETTRSYVPEESPSSDFFDDASPTVPEYQASTASPSRPTPASNENAWDRIRRETASHASISAPSPSSWGRQQPSASSEYSSYESEQQNGQREREAAQRQFDRMLDSERQLSQDGGDDNSNKKGWRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MR45</accession>
    <name>B8MR45_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tetratricopeptide repeat domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_054520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487051.1">
        <property type="nucleotide sequence ID" value="XM_002487006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MR45"/>
    <dbReference type="FunCoup" id="B8MR45">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MR45"/>
    <dbReference type="GeneID" id="8100390"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_054520"/>
    <dbReference type="eggNOG" id="ENOG502S442">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090376_2_0_1"/>
    <dbReference type="InParanoid" id="B8MR45"/>
    <dbReference type="OMA" id="KMYTLAI"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="PhylomeDB" id="B8MR45"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF3">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED12940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23249" checksum="7524A1A76161BAD2" modified="2009-03-03" version="1">MTSDIDSYTQYGLYLDPTTKSISLPSTEGQTPAQIEAINAELQQLNTLHRALIGLDSPNVPPPPLPINPKRSAQITKLRDTANTAFRKSNYAEAIKLYGYAIDMAISRPAWEPVNLVRDELSGLYANRAQAYMSQQSWPEGWIDSKCSAECKPIGNVKAWWRGGKCLVEMGRWDEARAWVEQALGIEGPASEGGKELVALLAEVEEGSKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRE5</accession>
    <name>B8MRE5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar epimerase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_055420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487151.1">
        <property type="nucleotide sequence ID" value="XM_002487106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRE5"/>
    <dbReference type="STRING" id="441959.B8MRE5"/>
    <dbReference type="GeneID" id="8102235"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_055420"/>
    <dbReference type="eggNOG" id="ENOG502SP57">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071330_0_1_1"/>
    <dbReference type="InParanoid" id="B8MRE5"/>
    <dbReference type="OMA" id="ETWILRP"/>
    <dbReference type="OrthoDB" id="3535423at2759"/>
    <dbReference type="PhylomeDB" id="B8MRE5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF9">
        <property type="entry name" value="EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="270" mass="29715" checksum="4AB93AEEDF9ACFCC" modified="2009-03-03" version="1">MATDKEGKQKEKSQSRTPKSRASDHPIKGRQGSSEDPKISSLSQQSCFTKLVKDLVDPLYQLPRSSTVTGFISREVLEQCLQSTRITSIIALSRRDLATTLTGNPKLKGLIMNNFLSYSLSIMQEVQGAEACILALGKARMLDNETNKTISIEYTLTAARAFNESFSAQKETTNDNNSKLRFPYLSGCGRRTGPDKVSMVHAGLQTEVSESYILRPVMVLSKGTTVRSVVFGMGPSVLVDDFAKVMLKLVLDGSQRLQILENSDINNLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRG7</accession>
    <name>B8MRG7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">1-aminocyclopropane-1-carboxylate deaminase, putative</fullName>
            <ecNumber evidence="9">3.5.99.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_056040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16933"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58360"/>
            <dbReference type="EC" id="3.5.99.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ACC deaminase/D-cysteine desulfhydrase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.7" evidence="9"/>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487215.1">
        <property type="nucleotide sequence ID" value="XM_002487170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRG7"/>
    <dbReference type="STRING" id="441959.B8MRG7"/>
    <dbReference type="GeneID" id="8100669"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_056040"/>
    <dbReference type="eggNOG" id="ENOG502QPS1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048897_2_1_1"/>
    <dbReference type="InParanoid" id="B8MRG7"/>
    <dbReference type="OMA" id="ERYHAGT"/>
    <dbReference type="OrthoDB" id="10266364at2759"/>
    <dbReference type="PhylomeDB" id="B8MRG7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008660">
        <property type="term" value="F:1-aminocyclopropane-1-carboxylate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019148">
        <property type="term" value="F:D-cysteine desulfhydrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009310">
        <property type="term" value="P:amine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06449">
        <property type="entry name" value="ACCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005965">
        <property type="entry name" value="ACP_carboxylate_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01274">
        <property type="entry name" value="ACC_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780">
        <property type="entry name" value="1-AMINOCYCLOPROPANE-1-CARBOXYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780:SF2">
        <property type="entry name" value="1-AMINOCYCLOPROPANE-1-CARBOXYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="8">
        <location>
            <begin position="19"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED13104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="347" mass="37386" checksum="7FBD081AEE2CAD20" modified="2009-03-03" version="1">MASVQLPEPFASIPRESFLFGPSPIQHLPKITKALGGKVGIYAKREDCNSGLAFGGNKTRKLEYLASDALAQGCDTLVSIGGFQSNHTRQVAAVATQLGMKVALVQEKWVNWEDPVYDKAGNIQLSRLMGADVRLDPSPFGIEHKGTLQNLKQEIIDKGGKPYYIPAGASDHPLGGLGFARWAFEVEQQETEMGIFFDTVIVCAVTGSTMAGMVAGFKLAQKKNNSKPRKVIGIDASATVKQTFDQILRIAKATGVKIGLSEDDITEEDIILDDRYHAGVYGIPDQQTIDAIKFGASTEAFITDPVYEGKSLAGMMDIVRKEEVAAGSNILYAHLGGQLALNAYTGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSC8</accession>
    <name>B8MSC8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein transport membrane glycoprotein Sec20, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_003720</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEC20 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487969.1">
        <property type="nucleotide sequence ID" value="XM_002487924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSC8"/>
    <dbReference type="STRING" id="441959.B8MSC8"/>
    <dbReference type="GeneID" id="8098068"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_003720"/>
    <dbReference type="eggNOG" id="ENOG502S7WD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038503_1_0_1"/>
    <dbReference type="InParanoid" id="B8MSC8"/>
    <dbReference type="OMA" id="WYLETTF"/>
    <dbReference type="OrthoDB" id="46868at2759"/>
    <dbReference type="PhylomeDB" id="B8MSC8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005606">
        <property type="entry name" value="Sec20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825">
        <property type="entry name" value="BNIP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825:SF0">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Sec20 C-terminal" evidence="12">
        <location>
            <begin position="164"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="345"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED12315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="378" mass="42648" checksum="B3BB42AEA4ABE30F" modified="2009-03-03" version="1">MSTIHTLQARLKETSNALYETKPLIDRLRNFTQAIGQGDEARLELGAEIHSRLKNVEEEMEILNVEVEGLEVTTGAQSKRKTGDNNGEKDAERKMVIGIAERLMSDLKRTRTEFRTAQLQANRNAEAARRKEREMLFARPSERAESTIKGSNKFTQNDIVVNASNDVTAALRRTHELMRTELSRSQFAQETLEQSTAALSSLSESYTNLDTVLSSTRTLVSSLLRSQKSDTWYLETSFYLLIGTIAWLVFRRILYGPMWWLAWMPVKMIYNVVASVIGLATISESIATTTSAVISATQVTSLPGETETASIVMDGADAPVMKTYEQVSAETENENSVLDKINHMVKGDQQHETAEEYDGPRNTKKRMWEEPVERRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSE8</accession>
    <name>B8MSE8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_000210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED11943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487597.1">
        <property type="nucleotide sequence ID" value="XM_002487552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSE8"/>
    <dbReference type="GeneID" id="8107449"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_000210"/>
    <dbReference type="HOGENOM" id="CLU_013929_14_2_1"/>
    <dbReference type="InParanoid" id="B8MSE8"/>
    <dbReference type="OMA" id="GEFAGHY"/>
    <dbReference type="OrthoDB" id="4324149at2759"/>
    <dbReference type="PhylomeDB" id="B8MSE8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="54"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED11943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="510" mass="58773" checksum="C9D9178AD6F417BF" modified="2009-03-03" version="1">MTPKLYKEEEELIAKALSACQHEKKPNFSKLSREYGVSRKKLSRRWHGLPSRSTRPPTRRLLSLDQEKALILWIEYLDNIGAPPTNQQIEESANYLLGKDFSGPGEAPRAGKNWVHDFIKRLPKQYVRIVQKPQEKERTVAEHYGEIERWFIDLELAIQQYKIRPQNLWNFNETGFIVGQEKDEAVVTAYPKTSKRVSSLSSRESITVIEGINAEGKIIPPLLIPKGKVHLEEWYRHIKNDDWLVAPALNGFITDEIAFEWLQHFNHFSRPGAFPDWQLLLMDNHTTHLTIQFVQYCEIWHIRPFRFPPHSTHFLQPLDGVPFQQYKHVHGRVVNKIARLEEAFEALVAEGDALKIYSEADDTIPSSPTTKSISLPSTAVKLRRYVNKIEKSIDSIKDILDKVSPGLSRRIKVVNQGSLTLAELGDLHRESFAKVRDIATRKNQKTTKRQVKASGALYVKDANRLIKRRHDGDLLKIYKSHVVGVPQPMEEVASTEPQNSRFFFDTQGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSK3</accession>
    <name>B8MSK3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribonuclease p/mrp subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_001540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487737.1">
        <property type="nucleotide sequence ID" value="XM_002487692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSK3"/>
    <dbReference type="GeneID" id="8098648"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_001540"/>
    <dbReference type="eggNOG" id="KOG2029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_182_0_1"/>
    <dbReference type="InParanoid" id="B8MSK3"/>
    <dbReference type="OMA" id="SMPDLNR"/>
    <dbReference type="OrthoDB" id="4225476at2759"/>
    <dbReference type="PhylomeDB" id="B8MSK3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED12083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="348" mass="38324" checksum="1FBC9E26A35B245C" modified="2009-03-03" version="1">MDAASSFGIGEPLSNPPEAKVDIVFVHDLGGHRINTWTFEQHKRIPSTFWPKALLRKTCNTSRILSFGYNSSFESFFPPSTDDKKIDDHATALLQCLEQLRSNTQTLGRPIIFVAHGLGGLVCAHALTDKHVANRSQYKPLVDSTRGLVFLGTPFEGSNEAQWASVARHFVKLTGLNTKLDHLDKRSQKLISINGTFIKFLLERLRSTAPVEIACFNEGLPTYFEDGSSKEIVSKSSAKILNIEPQPISADHTDMCKFWNASQDGYTRITKVLGDWIKALEPRSAKDNAKQPSVEMGAVYYSGEIRNNRGVLAGNVLGTTSDAVKITGSSYTFGPTTNAADVMRALDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSN3</accession>
    <name>B8MSN3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcineurin subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Calcineurin regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Protein phosphatase 2B regulatory subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_005080</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Composed of a catalytic subunit (A) and a regulatory subunit (B).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488124.1">
        <property type="nucleotide sequence ID" value="XM_002488079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSN3"/>
    <dbReference type="FunCoup" id="B8MSN3">
        <property type="interactions" value="842"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MSN3"/>
    <dbReference type="GeneID" id="8104492"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_005080"/>
    <dbReference type="eggNOG" id="KOG0034">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061288_10_1_1"/>
    <dbReference type="InParanoid" id="B8MSN3"/>
    <dbReference type="OMA" id="DTNFDRD"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="PhylomeDB" id="B8MSN3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005955">
        <property type="term" value="C:calcineurin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004723">
        <property type="term" value="F:calcium-dependent protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071444">
        <property type="term" value="P:cellular response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006873">
        <property type="term" value="P:intracellular monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000047">
        <property type="entry name" value="Calcineurin subunit B type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01697">
        <property type="entry name" value="PARVALBUMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="39"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="108"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="149"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED12470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="192" mass="21731" checksum="36E665A6BC857B58" modified="2009-03-03" version="1">MESHEVNNAALYNTRRRQGSIGGSQVLDRIIDASNFDRDEVDRLRKRFMKLDKDNSGTIEREEFLSLPQVSSNPLAPRMIAIFDEDGGGDVDFQEFVSGLSAFSSKGNKDEKLHFAFKVYDIDRDGYISNGELFIVLKMMVGSNLKDVQLQQIVDKTIMEADKDGDGKISFEEFKHMVESTDISMNMTLSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8MT24</accession>
    <name>B8MT24_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_001750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487758.1">
        <property type="nucleotide sequence ID" value="XM_002487713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MT24"/>
    <dbReference type="FunCoup" id="B8MT24">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="GeneID" id="8098669"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_001750"/>
    <dbReference type="eggNOG" id="KOG3798">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8MT24"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="PhylomeDB" id="B8MT24"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000048">
        <property type="entry name" value="Zn-dependent hydrolase/oxidoreductase family protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024884">
        <property type="entry name" value="NAPE-PLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038896">
        <property type="entry name" value="NAPE-PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="147"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="321"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine</name>
            <dbReference type="ChEBI" id="CHEBI:62537"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine</name>
            <dbReference type="ChEBI" id="CHEBI:62537"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR038896-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED12104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="432" mass="48265" checksum="6836A479A9EAF97C" modified="2009-03-03" version="1">MSHVLPRIRPQTFINTGMPIHRTMGSKSRGIADTRYTVTVSAPAALSAVPDTASDKSHWLRDTTDRGKVKGFRNPWKSAHDFSFPEIFKAMVHHKFLSGNSQRPDTTPPTVSVVEPTFLSSRTNPQTLRATWLGHACYHVEFPTGLRVLFDPVFEDRCSPFSWLGHKRFTPRPCDISDIPAIDCVIISHSHYDHLSYPTVLEIQKYHPSVQFCVPLGLKKWFADCGINNVIELDWWEDVELTLSKSTEKRPVTSSPTVDPSNDDITARISCLPCQHTSARSPFDKAATLWASWSIASGSKSVYFAGDTGYRAVPRLPKGVDDWGPELAHLPVCPAFKQIGEFRGPFDLGLIPIGAYMPRHVLSPVHSNPYDSVEIFKDTQCKKAMGIHWGTWAVAEENVLEPPQLLKEALTKSGLPETGLFDICNIGESREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTK7</accession>
    <name>B8MTK7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_004590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488067.1">
        <property type="nucleotide sequence ID" value="XM_002488022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTK7"/>
    <dbReference type="STRING" id="441959.B8MTK7"/>
    <dbReference type="GeneID" id="8104443"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_004590"/>
    <dbReference type="HOGENOM" id="CLU_2074714_0_0_1"/>
    <dbReference type="InParanoid" id="B8MTK7"/>
    <dbReference type="OrthoDB" id="331544at2759"/>
    <dbReference type="PhylomeDB" id="B8MTK7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED12413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="118" mass="13102" checksum="86DFB75972CFD047" modified="2009-03-03" version="1">MTNLVTNSILPHQAEGQLSSNGITAFESLSDVHSIFQIINAIVSNQSYGSKATNTEDWINRVPGRGFIDPSTGMDFPSLQKLGWTQSISLDDGIKRTVGWYKENGMTWWGDLQKILNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MU40</accession>
    <name>B8MU40_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_006900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
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    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
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        <property type="protein sequence ID" value="EED12673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="8106653"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_006900"/>
    <dbReference type="eggNOG" id="ENOG502R2RV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004278_0_0_1"/>
    <dbReference type="InParanoid" id="B8MU40"/>
    <dbReference type="OMA" id="DIWAGMM"/>
    <dbReference type="OrthoDB" id="5312224at2759"/>
    <dbReference type="PhylomeDB" id="B8MU40"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF6">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002875517" evidence="9">
        <location>
            <begin position="23"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="10">
        <location>
            <begin position="20"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="708"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="817"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="852"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="782"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="875"/>
            <end position="885"/>
        </location>
    </feature>
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        <location>
            <begin position="900"/>
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        </location>
    </feature>
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            <begin position="915"/>
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    </feature>
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        <location>
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        <location>
            <begin position="1031"/>
            <end position="1041"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED12673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1101" mass="118645" checksum="D17C638AC0E1C31C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
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            <taxon>Eurotiales</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="374"/>
        </location>
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        <location>
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            <end position="708"/>
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            <end position="300"/>
        </location>
    </feature>
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            <end position="321"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="708" mass="77723" checksum="01BCB160E6AD6436" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUU6</accession>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="203" mass="21885" checksum="F01B398F5CEF2445" modified="2009-03-03" version="1">MAENSPNGRTVVRRATYVGSQATPDYVVRSVALKPLSRVDTVRVETISEYEAGCSVHKECFGHMCKAPGGTILVPQSLASSKGETSKDYLKAAKYAFSGDAVGYADAVRNLNLTKSGKMRKDILGSAIAGSARLVIVPQVQFPGGTVAFPRNIASLMRIPVRVEDKDTGMPTNVIVSLDYCSATPNMKLFPDYERTPQYPAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUY0</accession>
    <name>B8MUY0_TALSN</name>
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        <submittedName>
            <fullName evidence="1">Reverse transcriptase, putative</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_110010</name>
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    <organism evidence="1 2">
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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                <person name="Andrianopoulos A."/>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED11821.1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_110010"/>
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    <dbReference type="HOGENOM" id="CLU_607174_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUY0"/>
    <dbReference type="OMA" id="RSSCHEG"/>
    <dbReference type="OrthoDB" id="4446818at2759"/>
    <dbReference type="PhylomeDB" id="B8MUY0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="451" mass="52367" checksum="D37BC22A3BB9AD5E" modified="2009-03-03" version="1" fragment="single">MEENEMGLHGFRISQIAWLQKDKENAIGKHGSLGIWFDSREAAEWLMDHGLLVGRTHIGSVVPFQVKEKRCYQCQGFGHLAWACKEWARHPGSTSTIDLMVTNHPESVVKCHLYHDHYGSDHRATYSQWSLQPVWNAEPKPRKAYDRSDWEKIGKSVHAQMAPLSTIQSITELDRVVEKLISCTTKAIDQHTPEMKPSPYAKRWFSPELKLQQGEVNRARRKWQESCATRGRQHTVLNALFQDMQRKRHAWARTIEKVKSQHWKEFLDKAGEGHLWKAASYMKPRESYSCIPPLKDGINEVVDNACKAKLFMDAFFPKMAAPEAMEDPEHNEEIRWDPITKEEVYRALQRMKTRKAPGEDEIPTLVWKQIWPYLSEEIFQIFTASINLGYYPQQWKRARIVVLRKPNKPDYAIPGAYRPISLLNTLGKVLEAVIAKRLSYYAETYNLLPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MV41</accession>
    <name>B8MV41_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zona occludens toxin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_109360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488513.1">
        <property type="nucleotide sequence ID" value="XM_002488468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MV41"/>
    <dbReference type="STRING" id="441959.B8MV41"/>
    <dbReference type="GeneID" id="8107168"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109360"/>
    <dbReference type="eggNOG" id="ENOG502QQSW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1365969_0_0_1"/>
    <dbReference type="InParanoid" id="B8MV41"/>
    <dbReference type="OMA" id="EDGQCES"/>
    <dbReference type="OrthoDB" id="2316594at2759"/>
    <dbReference type="PhylomeDB" id="B8MV41"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24301" checksum="21610EC9E813E30A" modified="2009-03-03" version="1">MPETQTTHQINKKTGRQKKRIGQAKGTMWKPKTACALFNICLGIFLEQDPAVGRVVALDEAHKYMNSSPESAAFTNSLLSTVRLQRHLGARVIVSTQEPTVSTALLNLCSTTIVHRFTSPEWLRILHRHLAAAAYDSQHDERVFAGAMDDDADAADSDTLFHRIVRLQVGEALLFSPTAMVISQDSEGQEPTFCYLGDKYVTIKIRARVTEDGGKSVLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8LSY7</accession>
    <name>B8LSY7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_064500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340370.1">
        <property type="nucleotide sequence ID" value="XM_002340329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LSY7"/>
    <dbReference type="STRING" id="441959.B8LSY7"/>
    <dbReference type="GeneID" id="8100217"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_064500"/>
    <dbReference type="eggNOG" id="KOG0385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_912695_0_0_1"/>
    <dbReference type="InParanoid" id="B8LSY7"/>
    <dbReference type="OMA" id="HIEYITC"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="PhylomeDB" id="B8LSY7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="163"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="211"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED22983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="305" mass="35267" checksum="08B1B30777D6758B" modified="2009-03-03" version="1">MESDSVFIQKLIRDSQKAVAMTSFDPNDLLAMPWKDVLDLCKKTSDDEEDVHSSSLPPTPRSPTFDQDEKIWLSQIERVQTTLFDGKVFSRHRAQPKTEVLTDLALYERRINKNRRVYDKTIHYYVSKESTLCKYGEAVPTITDSNSLKGKESSKVEFKHLKFCVVCGRTRKLDECLYCPRSYHEKCVNRQKDSTQKKYNPFNNDICPYHWCTKCGMTASNAGGLLLSCNSCPRSFCIDCIDLDEMESIEGELPEFLDLGYESPRHIEYITCGDCMKKARKEPRKREVTSTGGRVLRKRVRRHTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8LT51</accession>
    <name>B8LT51_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_069770</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340946.1">
        <property type="nucleotide sequence ID" value="XM_002340905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LT51"/>
    <dbReference type="FunCoup" id="B8LT51">
        <property type="interactions" value="334"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LT51"/>
    <dbReference type="GeneID" id="8104718"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_069770"/>
    <dbReference type="eggNOG" id="KOG0682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_1"/>
    <dbReference type="InParanoid" id="B8LT51"/>
    <dbReference type="OMA" id="FNAGSWL"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="PhylomeDB" id="B8LT51"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF4">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="54"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="536"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED23559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="570" mass="62026" checksum="390DE356CB581324" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTA6</accession>
    <name>B8LTA6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_059780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002339867.1">
        <property type="nucleotide sequence ID" value="XM_002339826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTA6"/>
    <dbReference type="STRING" id="441959.B8LTA6"/>
    <dbReference type="GeneID" id="8108641"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_059780"/>
    <dbReference type="HOGENOM" id="CLU_442905_0_0_1"/>
    <dbReference type="InParanoid" id="B8LTA6"/>
    <dbReference type="OrthoDB" id="4357294at2759"/>
    <dbReference type="PhylomeDB" id="B8LTA6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="395"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED22480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="617" mass="68196" checksum="5151E68F3C6A6B61" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTG6</accession>
    <name>B8LTG6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitochondrial 37S ribosomal protein S19, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_065040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340431.1">
        <property type="nucleotide sequence ID" value="XM_002340390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTG6"/>
    <dbReference type="FunCoup" id="B8LTG6">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LTG6"/>
    <dbReference type="GeneID" id="8102486"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_065040"/>
    <dbReference type="eggNOG" id="KOG0899">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144911_1_2_1"/>
    <dbReference type="InParanoid" id="B8LTG6"/>
    <dbReference type="OMA" id="EYVAFEV"/>
    <dbReference type="OrthoDB" id="2043at2759"/>
    <dbReference type="PhylomeDB" id="B8LTG6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_uS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF8">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED23044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="94" mass="10654" checksum="59CE9FF41D606B35" modified="2009-03-03" version="1">MYPTRSLLARSVWKGPNLVPLPLPRQIPPPPGTPPIKTQARSATILPNFVGLRFSVHNGKIYQDVLITEDMVGRKLGEFVPTRKRFTYKQSKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTY3</accession>
    <name>B8LTY3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNAse III, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_072070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341200.1">
        <property type="nucleotide sequence ID" value="XM_002341159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTY3"/>
    <dbReference type="STRING" id="441959.B8LTY3"/>
    <dbReference type="GeneID" id="8099993"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_072070"/>
    <dbReference type="eggNOG" id="ENOG502SSJ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000907_3_2_1"/>
    <dbReference type="InParanoid" id="B8LTY3"/>
    <dbReference type="OMA" id="AVYLDCN"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="PhylomeDB" id="B8LTY3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="12"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="142" mass="15552" checksum="EEF10CA9BB0E5687" modified="2009-03-03" version="1">MASLHSHRKDAVQAIQEITGYTFNDQSLLSEAVEAADFRNKDGNKDLALPGGAILKVFIIMEGRQRHQNRKTIASNANLAKKAVELGLKDYIQNNPAQGNLISQGPLATAMEAIIGAIYIDSDRDYSVLSEVITRMGLGWPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUB8</accession>
    <name>B8LUB8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="2">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_070960</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="2"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341078.1">
        <property type="nucleotide sequence ID" value="XM_002341037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUB8"/>
    <dbReference type="STRING" id="441959.B8LUB8"/>
    <dbReference type="GeneID" id="8104682"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_070960"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8LUB8"/>
    <dbReference type="OMA" id="PRIHLGV"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="PhylomeDB" id="B8LUB8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="10">
        <location>
            <begin position="35"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="9">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED23691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="293" mass="32843" checksum="E2389768B8CD7BF6" modified="2009-03-03" version="1">MATSKSTYSLSSTIKLTNGKIMPRIQLGVYLTSGRETETAVKNALEAGYRGIDSAQMYHNEKEVGRSILRFLEAEKHKPDGLKREDIFFTSKLASNVSYDATRQSIKKSIQASGLGYIDLFLIHSPYGGKAKRLECWRALEDAYEENEVRAVGVSNYGVKHLQELLATNPKIYPAVNQIEVHPFNTRTEITTFCQQNGIVVEAYAPLARAYRFGHPTIVSLSEKYGCTPAQLMVRWSLQHGYVPLPKSVNKERIVANARVEGFEIDSTDMNTLDGLDEYLVTGREDWDPVDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUJ8</accession>
    <name>B8LUJ8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14 15">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="3 14 15">4.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSTA_071670</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(R)-5-diphosphomevalonate + ATP = isopentenyl diphosphate + ADP + phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:23732"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.33"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:23733"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="3 14 15"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341158.1">
        <property type="nucleotide sequence ID" value="XM_002341117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUJ8"/>
    <dbReference type="FunCoup" id="B8LUJ8">
        <property type="interactions" value="690"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LUJ8"/>
    <dbReference type="GeneID" id="8102635"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_071670"/>
    <dbReference type="eggNOG" id="KOG2833">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040369_4_2_1"/>
    <dbReference type="InParanoid" id="B8LUJ8"/>
    <dbReference type="OMA" id="LTLHAMM"/>
    <dbReference type="OrthoDB" id="10253702at2759"/>
    <dbReference type="PhylomeDB" id="B8LUJ8"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000018">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000005">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977:SF3">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8 15" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="17">
        <location>
            <begin position="13"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Mvd1 C-terminal" evidence="16">
        <location>
            <begin position="201"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR015950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EED23771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="404" mass="43268" checksum="3D334B6FBC53923D" modified="2009-03-03" version="1">MTDSNVFRATTTAPVNIAVIKYWGKRDATLNLPTNSSLSVTLSQRSLRTVTTASCSPNYPATEGDTLTLNGKPENIQASKRTLACLSSLRALRKELESADPSLPKLSSYPLRVVSENNFPTAAGLASSAAGFAALVRAIADLYELPQSPTELSRIARQGSGSACRSLQGGYVAWRAGVKEDGSDSLAEEIAPASHWPEMRALILVVSAEKKDVPSTTGMQTTVSTSPLFATRAEHIVPRRMTGMEEAITKRDFAAFADLTMRDSNNFHAVCLDSEPPIFYLNDVSRAAIRLVNDINRLAGKTVAAYTFDAGPNAVIYYLDEVSELVGGTFKTILGGELEGWEGPFGDRLKGVSAGVDLNSLDSRAIEVLKTGISRVILTGVGEGPQKIDTHLVSEKGDILSLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8LV00</accession>
    <name>B8LV00_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_061120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340008.1">
        <property type="nucleotide sequence ID" value="XM_002339967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LV00"/>
    <dbReference type="GeneID" id="8101239"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_061120"/>
    <dbReference type="eggNOG" id="ENOG502RK4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005777_0_0_1"/>
    <dbReference type="InParanoid" id="B8LV00"/>
    <dbReference type="OMA" id="MDLRFYH"/>
    <dbReference type="OrthoDB" id="4798501at2759"/>
    <dbReference type="PhylomeDB" id="B8LV00"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045793">
        <property type="entry name" value="PcRGLX/YetA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048330">
        <property type="entry name" value="PcRGLX/YetA_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048331">
        <property type="entry name" value="PcRGLX/YetA_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048329">
        <property type="entry name" value="PcRGLX_1st"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40081">
        <property type="entry name" value="CONCANAVALIN A-LIKE LECTIN/GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40081:SF1">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19501">
        <property type="entry name" value="PcRGLX_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21345">
        <property type="entry name" value="PcRGLX_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21346">
        <property type="entry name" value="PcRGLX_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PcRGLX/YetA-like N-terminal RIFT barrel" evidence="1">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="PcRGLX/YetA-like central beta-sandwich" evidence="2">
        <location>
            <begin position="119"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="PcRGLX/YetA-like C-terminal alpha/alpha toroid" evidence="3">
        <location>
            <begin position="469"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED22621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="905" mass="103229" checksum="10D9C89E828EEE75" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8LV27</accession>
    <name>B8LV27_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monoxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_061380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340035.1">
        <property type="nucleotide sequence ID" value="XM_002339994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LV27"/>
    <dbReference type="STRING" id="441959.B8LV27"/>
    <dbReference type="GeneID" id="8105646"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_061380"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_6_3_1"/>
    <dbReference type="InParanoid" id="B8LV27"/>
    <dbReference type="OMA" id="GEMYEWQ"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="PhylomeDB" id="B8LV27"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000153">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="7"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="284"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED22648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="437" mass="48360" checksum="6422A8351E45F093" modified="2009-03-03" version="1">MIEARAIEVAIIGGGITGLTLALGLQKRNTNFHIYERAQSLREIGAGIGFTPNAERAMLALDPRIHEAFKSVASKNASDWFQWVDGFSGVNNDKDTVKEDLLFNMYLGERGFEGCHRAQFLKELVNHLPQGCVTFGACLDTIIDQGENERILLKFHNGTIAEADLVIGCDGIRSRVRQLILGENNPASYPAYTHKKAYRGLIPMEKALPALGESKVNTRLMHLGPDAHTLTFPVAGGKLMNVVAFVTDPGEWPYTEKLSAPAEKKSAIEGFSKFGGAVRTIMNLLPEDLDEWAIFDTYDHPASTYYHGRICIAGDAAHASSPHHGAGAGAGIEDVTVLATVIEVAQTTLLESPDKSRSGVLNAALATYNAVRLERSQWLVESSRILGEIYEWQYKPTGRDKKKCEEEVYWRSHKIWDYDIGQMLQETTEYYKQRVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8LV48</accession>
    <name>B8LV48_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Efflux pump antibiotic resistance protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_065530</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340485.1">
        <property type="nucleotide sequence ID" value="XM_002340444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LV48"/>
    <dbReference type="GeneID" id="8101275"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_065530"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_25_2_1"/>
    <dbReference type="InParanoid" id="B8LV48"/>
    <dbReference type="OMA" id="WCYYITI"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="PhylomeDB" id="B8LV48"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06179">
        <property type="entry name" value="MFS_TRI12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053791">
        <property type="entry name" value="MFS_Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="553"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="58"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED23098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="612" mass="66138" checksum="9CEA0740CAEC7FFF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVV8</accession>
    <name>B8LVV8_TALSN</name>
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        <submittedName>
            <fullName evidence="5">Nucleoside hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_076910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341711.1">
        <property type="nucleotide sequence ID" value="XM_002341670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVV8"/>
    <dbReference type="STRING" id="441959.B8LVV8"/>
    <dbReference type="GeneID" id="8101975"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_076910"/>
    <dbReference type="eggNOG" id="KOG2938">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036838_9_0_1"/>
    <dbReference type="InParanoid" id="B8LVV8"/>
    <dbReference type="OMA" id="RNVVSMF"/>
    <dbReference type="OrthoDB" id="5783963at2759"/>
    <dbReference type="PhylomeDB" id="B8LVV8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF56">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G11790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED24324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="422" mass="46731" checksum="7D6049EC218B3206" modified="2009-03-03" version="1">MAKNKIIIDTDPGIDDILAMLLAFASSPEEIEVLLISLTFGNIEVESCLRNVVSMLHILEREMAWRKKQGRPEGFDTLRAHKPVIAVGAKQPLDDQKMLADYFHGKDGLGGIHFSHPHLTPGESWEHLFDPISDPEVLPNVGPSPSESHQSFIPSKQPASDEILRVLKENEENTVTIVAVGPLTNLALAAAKDPETFLRVKEVVVMGGTINDPGNVTPVGEFNAYADAVAAARVFALTSPNPQSTLPPSKRLRPYPAKLSKRLTLKLFPLDITSHHDLIRGDFDHTITPLLQSGSPLAEWVDAFMAHVFQTLERLHPGHEGAKASLTLHDPVCVWYALTSDDPRWRPTPTSPEDIRIETVGQWTRGMCVVDRRNRHKVEDEVESHSDHGLWLSSRAGNRIIRIGESPGGDTFGMLLMKKLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8LW61</accession>
    <name>B8LW61_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_074670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341476.1">
        <property type="nucleotide sequence ID" value="XM_002341435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LW61"/>
    <dbReference type="STRING" id="441959.B8LW61"/>
    <dbReference type="GeneID" id="8100195"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_074670"/>
    <dbReference type="eggNOG" id="ENOG502SDRZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008005_1_0_1"/>
    <dbReference type="InParanoid" id="B8LW61"/>
    <dbReference type="OMA" id="LNVMEGN"/>
    <dbReference type="OrthoDB" id="3438840at2759"/>
    <dbReference type="PhylomeDB" id="B8LW61"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="764"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED24089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="857" mass="93344" checksum="CDA60580C4873B01" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXL5</accession>
    <name>B8LXL5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_078710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341903.1">
        <property type="nucleotide sequence ID" value="XM_002341862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXL5"/>
    <dbReference type="GeneID" id="8109412"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_078710"/>
    <dbReference type="eggNOG" id="ENOG502S78C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065192_0_0_1"/>
    <dbReference type="InParanoid" id="B8LXL5"/>
    <dbReference type="OMA" id="KFPMTWP"/>
    <dbReference type="OrthoDB" id="5538558at2759"/>
    <dbReference type="PhylomeDB" id="B8LXL5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050563">
        <property type="entry name" value="4-hydroxybenzoyl-CoA_TE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793">
        <property type="entry name" value="4-HYDROXYBENZOYL-COA THIOESTERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793:SF39">
        <property type="entry name" value="THIOESTERASE_THIOL ESTER DEHYDRASE-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED24516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="38964" checksum="FDF40DF7D7576AA2" modified="2009-03-03" version="1">MTMSPTHGFQRSQFSHLLTLGSAQRNIRLFSAASYRFSSSYLSSPQTPPTQESTAVKKAKPHRIDPRWLTDTKRRIGKCLMFGLKPAQVDEAGRILQRLARDWRELIAGTDGFLTHTTRRALFRRDVVWGDMDSMVRSRPGRLFSTRDLICARADHAYLGFRPGHINNVAYVRYAETARVNLMHNYATHIDPAHQQEWLNTVGNKGIGLILQSIKIDYKFPMTWPDKITVYHRLTQNPSDTLTKSYFQQEALILSECKQRPAARVIEQNFLYDYTQLRKTDTAPEFMLQQFQEAWALQEESKKLWQQQVADIENEVRRLELESWNNPNAVEDMGSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXQ4</accession>
    <name>B8LXQ4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_079110</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received. Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins. Required for the RNA polymerase II and SPT15/TBP recruitment to the target genes. Involved in chromosome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2A.Z forms a heterodimer with H2B. H2A.Z associates with the VPS72/SWC2 subunit of the SWR1 chromatin remodeling complex. Also interacts with RBP1/DNA-directed RNA polymerase II largest subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341942.1">
        <property type="nucleotide sequence ID" value="XM_002341901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXQ4"/>
    <dbReference type="FunCoup" id="B8LXQ4">
        <property type="interactions" value="1056"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LXQ4"/>
    <dbReference type="GeneID" id="8102487"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_079110"/>
    <dbReference type="eggNOG" id="KOG1757">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062828_2_1_1"/>
    <dbReference type="InParanoid" id="B8LXQ4"/>
    <dbReference type="OMA" id="MNKKGAP"/>
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    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140898">
        <property type="term" value="P:CENP-A eviction from euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000021">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="13">
        <location>
            <begin position="22"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="14">
        <location>
            <begin position="102"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED24555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="139" mass="14818" checksum="21390B49A053F3AC" modified="2009-03-03" version="1">MAGGKGKSVGGKAAPGKDAAGKSQKSHSAKAGLQFPCGRVKRFLKNNTQNKMRVGAKAAVYVTAVLEYLTAEVLELAGNAAKDLKVKRITPRHLQLAIRGDEELDTLIRATIAFGGVLPRINRALLLKVEQKKKGKVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXY8</accession>
    <name>B8LXY8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_062900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340190.1">
        <property type="nucleotide sequence ID" value="XM_002340149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXY8"/>
    <dbReference type="GeneID" id="8108479"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_062900"/>
    <dbReference type="eggNOG" id="ENOG502S37A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_1_1"/>
    <dbReference type="InParanoid" id="B8LXY8"/>
    <dbReference type="OMA" id="RKLEHIG"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="PhylomeDB" id="B8LXY8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF16">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="195" mass="21914" checksum="CD704B045B76910A" modified="2009-03-03" version="1">MPTDFSPPPSFSIPTERLHISYIQPGNPDHTSFFMHVWNLEEIKRFIGKRDLDTLEKVDVFIKNQVQAEYNRAGYGRFLVSLKPHPQASLAESKHIGLVSLILREPPNGYPHPDIGYAFVPEHWGKGYATEAAIALINYARREFGVTGVFGRRVLEKIGLEFRGELTLRAFDGIQSAVYALPGMNPDLSVYGIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYL9</accession>
    <name>B8LYL9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SNF2 family helicase/ATPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_068050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340764.1">
        <property type="nucleotide sequence ID" value="XM_002340723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYL9"/>
    <dbReference type="STRING" id="441959.B8LYL9"/>
    <dbReference type="GeneID" id="8101982"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_068050"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_2_8_1"/>
    <dbReference type="InParanoid" id="B8LYL9"/>
    <dbReference type="OMA" id="QSCNHPD"/>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="PhylomeDB" id="B8LYL9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SNF2 family helicase/ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF14">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="290"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="808"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="230"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="687"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="982"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="687"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="722"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="771"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1006"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1030"/>
            <end position="1045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED23377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1045" mass="116801" checksum="80B43433EC044B23" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZN3</accession>
    <name>B8LZN3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_097050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the citrate synthase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EED22456.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002479374.1"/>
    </dbReference>
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    <dbReference type="STRING" id="441959.B8LZN3"/>
    <dbReference type="GeneID" id="8109486"/>
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    </dbReference>
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    <dbReference type="OMA" id="SGVMAHW"/>
    <dbReference type="OrthoDB" id="435022at2759"/>
    <dbReference type="PhylomeDB" id="B8LZN3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
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        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
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        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
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        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42871">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42871:SF1">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED22456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="475" mass="52621" checksum="40EA70B44081909E" modified="2009-03-03" version="1">MAIKPVKIAQDCLLVLDSRTAQSYQIPIKDNAILGSDIGNIVGLADPDFEEEEGEVNSHTNGNSNGHVKSTANGTAVRRKQRGLSVLDPGLENIAIMKSSITFIDGQRGIIKFRDMMIEDLFRDYVYEDVMHLLIWDEIPTEAKKQDTRIIMGSAGVPTEAVRKVIESFPREAESYHMILAGMAAFASGDTIIATARHQQKPVFHGNLSQADPALLRTIQYMATTTALVYCHKHNLEFTNPDPSQSLVENLVMMMGFHDKEYEGKPKPDARIVECLNKLWILYADFEMTASTAAVLQAGSALSDPVSCAISGIVAGHGPLHGGAIELAYESFGKIGSPENVKPYIAAVKAQKARLFGYGHRVLKNRDPRGALMKEIMGGKLAEDFARNPMLQIALTMDRVAREDPYFIERNLHVNVDLYGSFPYIALGFHKDAITAVTILSRFAGPLAHWRESLTQPIKLWRPRQVYESNVQIPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZQ6</accession>
    <name>B8LZQ6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_080710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477801.1">
        <property type="nucleotide sequence ID" value="XM_002477756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZQ6"/>
    <dbReference type="GeneID" id="8101375"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_080710"/>
    <dbReference type="HOGENOM" id="CLU_067893_2_0_1"/>
    <dbReference type="InParanoid" id="B8LZQ6"/>
    <dbReference type="OrthoDB" id="4436005at2759"/>
    <dbReference type="PhylomeDB" id="B8LZQ6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED20838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="11736" checksum="0EF40A784CAE7F33" modified="2009-03-03" version="1" fragment="single">ASDLLFLQIFSPTGKSTLIVNIYNAPAGFIRAGEAAKALTTLPEAYLPQATILAGNLNLLHNRWQPSLHRSPTPFAELFINWLDLQGLVLISDIDCPTHERGNVLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZX5</accession>
    <name>B8LZX5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_081400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477870.1">
        <property type="nucleotide sequence ID" value="XM_002477825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZX5"/>
    <dbReference type="GeneID" id="8104778"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_081400"/>
    <dbReference type="eggNOG" id="ENOG502SVBM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED20907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="146" mass="16063" checksum="D9EA454445E69143" modified="2009-03-03" version="1">MKDVFDMSKWHKSTGIFRSPPLKDPLRPNSFPAVTIHEKQDVLVHNLLQNLAEAGDILLDSPAVPTTSLYFPDITMAQVEESVLQAGNTAPGSDEIPTCILKVAWPLIKDKTNRSPISTWQRTGALGGTEYGMDLYILQSISKATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8M039</accession>
    <name>B8M039_TALSN</name>
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        </submittedName>
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        <name evidence="6" type="ORF">TSTA_083680</name>
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    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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                <person name="Andrianopoulos A."/>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
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    <dbReference type="GeneID" id="8101461"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_083680"/>
    <dbReference type="eggNOG" id="KOG4436">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_005062_1_0_1"/>
    <dbReference type="InParanoid" id="B8M039"/>
    <dbReference type="OMA" id="PNVEMFR"/>
    <dbReference type="OrthoDB" id="159449at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000027">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
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    </dbReference>
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        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00566">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="422"/>
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        </location>
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            <end position="182"/>
        </location>
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            <end position="576"/>
        </location>
    </feature>
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        <location>
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            <end position="812"/>
        </location>
    </feature>
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        </location>
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        <location>
            <begin position="828"/>
            <end position="855"/>
        </location>
    </feature>
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            <end position="56"/>
        </location>
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        </location>
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        </location>
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        </location>
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        <location>
            <begin position="743"/>
            <end position="755"/>
        </location>
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        <location>
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            <end position="765"/>
        </location>
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        <location>
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            <end position="799"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED21136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="901" mass="100470" checksum="0EB84016AAC84ABA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8M052</accession>
    <name>B8M052_TALSN</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="8101474"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_083810"/>
    <dbReference type="eggNOG" id="ENOG502QZQY">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_6_1_1"/>
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    <dbReference type="OMA" id="MRQESCV"/>
    <dbReference type="OrthoDB" id="3945463at2759"/>
    <dbReference type="PhylomeDB" id="B8M052"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="209"/>
        </location>
    </feature>
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            <end position="174"/>
        </location>
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        <location>
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            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED21149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="235" mass="27539" checksum="0FB898D1FBA3E002" modified="2009-03-03" version="1">MAKSGNLQDSWLQDLTTQRCHFAASETGWTNKDWGKNPSKDFKKLSNTVMELTTEVVLLRLRLASAEKALLHEKRRQIRKKPLLLDLPNKQEGGAIFFSPSKIQQARELFQQKEDHATQEKARKDDKKLQQQLAKEAKEQEKQERAQIRQKKRDEREKQAAEKERQKLEQKLAKQADLQLQKDALAKAKQPTSRTNPNSKKLKHKQRSEIEDEVIDEVITTNRRGREIRLPTRFR</sequence>
</entry>
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    <accession>B8M0B8</accession>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="8101539"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_084460"/>
    <dbReference type="eggNOG" id="ENOG502T3RT">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1062360_0_0_1"/>
    <dbReference type="InParanoid" id="B8M0B8"/>
    <dbReference type="OMA" id="WERITHR"/>
    <dbReference type="OrthoDB" id="4207386at2759"/>
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    </dbReference>
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        <location>
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            <end position="31"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="262" mass="30919" checksum="4A6685C136F26AF4" modified="2009-03-03" version="1">MDSSRYWPPPNGVRSRRALENGDFTARNPETGPYGSSLKCLPRERSNYMRWWRQATLHMEQLLWGDHSERQSAKERIDQVNEEIRAFNITCNRNEECGTIDGIDWIRAGRQLDLAVRDKCFYNSTARFEDVRDFIWERIQNRTYPEAWEVTWYKFEDKIRKRSSNFENIRNGNDLDIQDGAYRFYENPMTSSPSVNTPSSSIPRRRSARHQNRHGPLSVQGGGISRRGGAELRLSHRRHRLRLEELETQLASPGWKKMETLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0C3</accession>
    <name>B8M0C3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_084510</name>
    </gene>
    <organism evidence="2 3">
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        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478183.1">
        <property type="nucleotide sequence ID" value="XM_002478138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0C3"/>
    <dbReference type="GeneID" id="8102733"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_084510"/>
    <dbReference type="eggNOG" id="ENOG502RZ04">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062257_0_0_1"/>
    <dbReference type="InParanoid" id="B8M0C3"/>
    <dbReference type="OMA" id="IMVADDR"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="PhylomeDB" id="B8M0C3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052751">
        <property type="entry name" value="Plant_MAPKKK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48011">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTIONAL COMPLEX SUBUNIT CAF120-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48011:SF4">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="267" mass="30441" checksum="EA163032ECC4F50F" modified="2009-03-03" version="1">MALYDILCMAAKSYIDVLEMNEVFEEVDGRFDFSGTLIVYQVNSELHHAFSKARYSSPSEVNAKHFRSDIRIPVSAYNPLFPFNLTRAPDSIPNDAFIKRPRLISYDRICEGPQSNLIAESLLREAYVCELLTEHMHPNIASYLGCQVSNEVNPNNFMKRKSRAMRQTTKDYSNVIAGIESGIRHLHSLGLVHNDINPSNIMLDGDQAVIIDFGSCRPVGESLQDVGRTYEWYDEKVEQSIPENDLSALEEIRIWLGDKSHEFQFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0E1</accession>
    <name>B8M0E1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Gram-negative bacteria binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_084690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478201.1">
        <property type="nucleotide sequence ID" value="XM_002478156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0E1"/>
    <dbReference type="STRING" id="441959.B8M0E1"/>
    <dbReference type="GeneID" id="8106075"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_084690"/>
    <dbReference type="eggNOG" id="ENOG502QRX5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019533_1_2_1"/>
    <dbReference type="InParanoid" id="B8M0E1"/>
    <dbReference type="OMA" id="DTWAPTW"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="PhylomeDB" id="B8M0E1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000178">
        <property type="entry name" value="Glycoside hydrolase family 16 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF55">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="7">
        <location>
            <begin position="112"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED21238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="451" mass="50271" checksum="F8F2AC25206FE2DC" modified="2009-03-03" version="1">MDVRNPFSDSAAPSVVASVASGATHSAQDSIGEFPFRDSTYTRAPVKRRFKSYLLTGEYERPWVNDKRLKRIRVNNYIIWGFLVAGLAVSGYINYHATTQVPKHNYCLILDDDFSSLDTSVWTREVQVGGFGTGEFEWTTTDDRNVFVDEEGLHIVPTLTTDTTPITAAEITNGYTLNLTKAGGDGTCTGTTNEACSVRSNSTLGNVINPVRSARLNTNGSKSITYGRVEVVARFPAGDWLWPAIWMMPTNSAYGPWPASGEIDLSESRGNDISYVNGGRDVMSSSIHWGPNSDLDAFWLSTRGKSLRRTDFSKEFHTFGLEWSEEYLFTWVDNPLQQVMYWSFPKNTNMFQRGRFTGRTANNSLVTDPWSHTGRPNSPFDQPFYLILNVAVGGTNGWFKDGIGNKPWTDAGHGPADFYASMDQWYPTWANGSSRGMTVKSVKMWQQGACP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0E7</accession>
    <name>B8M0E7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flavoprotein oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_084750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478207.1">
        <property type="nucleotide sequence ID" value="XM_002478162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0E7"/>
    <dbReference type="STRING" id="441959.B8M0E7"/>
    <dbReference type="GeneID" id="8106081"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_084750"/>
    <dbReference type="eggNOG" id="ENOG502SAW3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_366051_0_0_1"/>
    <dbReference type="InParanoid" id="B8M0E7"/>
    <dbReference type="OMA" id="EMHTEDA"/>
    <dbReference type="OrthoDB" id="5369448at2759"/>
    <dbReference type="PhylomeDB" id="B8M0E7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="780" mass="86828" checksum="2923257ABBD967BE" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0P2</accession>
    <name>B8M0P2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_086580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478388.1">
        <property type="nucleotide sequence ID" value="XM_002478343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0P2"/>
    <dbReference type="GeneID" id="8110064"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_086580"/>
    <dbReference type="HOGENOM" id="CLU_1489952_0_0_1"/>
    <dbReference type="InParanoid" id="B8M0P2"/>
    <dbReference type="OrthoDB" id="10527154at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED21425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="181" mass="20828" checksum="CCEE8B3F6CA0DC20" modified="2009-03-03" version="1">MTAGYISPHKKLIEREEEYRSAELFDWLPERHDVSEDIGQPFGMGLNEMTGLDRMTHAIVMKKGDTQIFRIKIIIPEGTDEYVFVLNVERIVFVARYSAPTFRAFNPRDLHKSMLNLARSMNARVAVRDGKDFTLSPSTPEDYELAIYSSADEFDTTGARDQSYYETESMHFPNDRVQCGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0Q6</accession>
    <name>B8M0Q6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_086720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478402.1">
        <property type="nucleotide sequence ID" value="XM_002478357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0Q6"/>
    <dbReference type="STRING" id="441959.B8M0Q6"/>
    <dbReference type="GeneID" id="8110078"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_086720"/>
    <dbReference type="eggNOG" id="ENOG502SR2C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042941_2_3_1"/>
    <dbReference type="InParanoid" id="B8M0Q6"/>
    <dbReference type="OMA" id="DMFHTLH"/>
    <dbReference type="OrthoDB" id="4222962at2759"/>
    <dbReference type="PhylomeDB" id="B8M0Q6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED21439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="31356" checksum="4589D3EE931A04A6" modified="2009-03-03" version="1">MFGALYRIKMDEEENEEKENLLETDTTTIRPPAKRNNQILRLLFIIGVSLNTLFGILGIFTFASFLNSGKSSYENGFDTDLEPAREKIDLIVKTFTGGVELDDAGNFYTDDGGHEYVGPPGPEVDEAWETLLGLNLDLDEDEVVLKGSTFQWPESGNYFTGIDVYHSLHCLNRLRQAIYPEYYTRIFNHPSDPSRKNHIETLDHCINHIRQAIQCHADLTPMEWRLDGNKIILKTNTQHTCRNFEQINGWALSKRTKFEDIHSWRNGSLQIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1V4</accession>
    <name>B8M1V4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UBX domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_085630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478295.1">
        <property type="nucleotide sequence ID" value="XM_002478250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1V4"/>
    <dbReference type="FunCoup" id="B8M1V4">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M1V4"/>
    <dbReference type="GeneID" id="8104528"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_085630"/>
    <dbReference type="eggNOG" id="KOG1363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020031_2_0_1"/>
    <dbReference type="InParanoid" id="B8M1V4"/>
    <dbReference type="OMA" id="VYAFVEC"/>
    <dbReference type="OrthoDB" id="1026733at2759"/>
    <dbReference type="PhylomeDB" id="B8M1V4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="3">
        <location>
            <begin position="414"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED21332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="533" mass="60022" checksum="E8772DD63EB4590D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2H7</accession>
    <name>B8M2H7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GABA permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_088770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478604.1">
        <property type="nucleotide sequence ID" value="XM_002478559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2H7"/>
    <dbReference type="FunCoup" id="B8M2H7">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M2H7"/>
    <dbReference type="GeneID" id="8106974"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_088770"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_5_0_1"/>
    <dbReference type="InParanoid" id="B8M2H7"/>
    <dbReference type="OMA" id="LLMAQYT"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="PhylomeDB" id="B8M2H7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF3">
        <property type="entry name" value="POLYAMINE TRANSPORTER TPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED21641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="531" mass="56854" checksum="9DA3D509CE0600D4" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2R0</accession>
    <name>B8M2R0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone acetyltransferase ESA1</fullName>
            <ecNumber evidence="4">2.3.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Histone acetyltransferase esa1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15 24">protein 2-hydroxyisobutyryltransferase ESA1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 25">protein acetyltransferase ESA1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 26">protein crotonyltransferase ESA1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">TSTA_092130</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(2E)-butenoyl-CoA + L-lysyl-[protein] = N(6)-(2E)-butenoyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:137954"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:53909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:131780"/>
            <dbReference type="ChEBI" id="CHEBI:144968"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:24181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:45949"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="4"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478934.1">
        <property type="nucleotide sequence ID" value="XM_002478889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2R0"/>
    <dbReference type="FunCoup" id="B8M2R0">
        <property type="interactions" value="942"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M2R0"/>
    <dbReference type="GeneID" id="8099395"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_092130"/>
    <dbReference type="eggNOG" id="KOG2747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011815_2_0_1"/>
    <dbReference type="InParanoid" id="B8M2R0"/>
    <dbReference type="OMA" id="QYQRHGY"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="PhylomeDB" id="B8M2R0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044016">
        <property type="term" value="F:histone H3K4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106226">
        <property type="term" value="F:peptide 2-hydroxyisobutyryltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140065">
        <property type="term" value="F:peptide butyryltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140064">
        <property type="term" value="F:peptide crotonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140861">
        <property type="term" value="P:DNA repair-dependent chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031453">
        <property type="term" value="P:positive regulation of heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000022">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000002">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF218">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE ESA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="30" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 30" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="29">
        <location>
            <begin position="211"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="80"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="28">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="27">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00074445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00075313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00076782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00077673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="EED21971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="499" mass="57489" checksum="09B4A930C7DBDB03" modified="2009-03-03" version="1">MAGRDDAPTPDPAEKGFATLATLRIGVKAMVEKDGSHRKAEILSMRQRKDTLYVYVHYVDFNKRLDEWIPATRIDLSQEVEWPAPEKPEKKKAPSKSASQKRARAGSRDVSSTPDLLTGKNLNIGKAARPSKAGGKENRSEETPLNLSLTGSEAVSIDGTPKGDSEDVDMADAVDTKLEPQEKMLGDMTREEEIEKLRTSGSMTQNPTEIHRVRNLTRLQMGKHEMEPWYFSPYPESFQDADIVYIDEFCLSYFDNKRQFERHRSKCTLVHPPGNEIYRDDHISFFEVDGRRQRTWCRNLCLLSKLFLDHKTLYYDVDPFLFYCMCTRDETGCHLTGYFSKEKDCAEGYNLACILTLPQYQRRGFGRLLIQFSYELSKREGKLGSPEKPLSDLGLLSYRQYWREVLVELLLESGREAISEFELATLTSMTEKDVHETLLVLNMLRYHKGNWIIVIPDAIVEQHNKRLEKEKIKGVKKIDPAKLQWKPPVFTASSRTWNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8M300</accession>
    <name>B8M300_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_092180</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478939.1">
        <property type="nucleotide sequence ID" value="XM_002478894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M300"/>
    <dbReference type="FunCoup" id="B8M300">
        <property type="interactions" value="705"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M300"/>
    <dbReference type="GeneID" id="8099400"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_092180"/>
    <dbReference type="eggNOG" id="KOG2907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093932_1_1_1"/>
    <dbReference type="InParanoid" id="B8M300"/>
    <dbReference type="OMA" id="EMQYHTL"/>
    <dbReference type="OrthoDB" id="10056816at2759"/>
    <dbReference type="PhylomeDB" id="B8M300"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10507">
        <property type="entry name" value="Zn-ribbon_RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034004">
        <property type="entry name" value="Zn_ribbon_RPA12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF14">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="12">
        <location>
            <begin position="79"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED21976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="121" mass="13048" checksum="C0B80472F4507FBD" modified="2009-03-03" version="1">MSAIGSLIFCTDCGNLLQESTGSPDAILVCEACGAKNKDILPQTIVSESKPNAFPSALRAKRSALQTLTAADRTMEAVTQYTCAECGRKEMFFTTAQLRSADEGTTVFYRCVCGYKETVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3B4</accession>
    <name>B8M3B4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_095350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479249.1">
        <property type="nucleotide sequence ID" value="XM_002479204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3B4"/>
    <dbReference type="GeneID" id="8103862"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_095350"/>
    <dbReference type="eggNOG" id="ENOG502SSR4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087045_2_0_1"/>
    <dbReference type="InParanoid" id="B8M3B4"/>
    <dbReference type="OMA" id="MSSHPLE"/>
    <dbReference type="OrthoDB" id="4227565at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED22286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="236" mass="25762" checksum="DFD9805ADB172F08" modified="2009-03-03" version="1">MAPISFLTDTIFCFVRDISSAFITLSSSTLVARFDPLPESTTSPSSLEQTIHKRQNQILSIPATYAFLNTSPTPGTVIGVVLGVVGGVVILVIVLYQTLGWGNTNESIVVEEEVSEVGVVRTGSRRSAVPRPRSSRPGGRRVVDEIVEVRERPHSSRRSDVDVDDEVIVIEEDGTTGTHYSDDVVEVEEEESSVATSPRPPRRRGTGGSYRRVDPLAYGGGDEPSQIVAWKRIQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3F1</accession>
    <name>B8M3F1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_095720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479286.1">
        <property type="nucleotide sequence ID" value="XM_002479241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3F1"/>
    <dbReference type="GeneID" id="8105883"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_095720"/>
    <dbReference type="eggNOG" id="ENOG502RUBK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013756_2_1_1"/>
    <dbReference type="InParanoid" id="B8M3F1"/>
    <dbReference type="OMA" id="KWMALPF"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="PhylomeDB" id="B8M3F1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="49"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED22323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="509" mass="55621" checksum="6771DF6F086A14E8" modified="2009-03-03" version="1">MGQHDETTPLLTSPHQNINNDSGTTRQRTTRSLLWSPIQRRVMIAGGLLLLSINFGAFMAQAPQLQIFEDIICKNYMQSIDPSLLNDTIDVCKSPAVQKELALVTGWKNTFDILPSIAMALPYGILADRIGRRPVMIMSFASLICSDTWAKIVCWFNLPLRLTWLAGLFQIPGGGNLVATTMVMTVVADVFSAGERNTAIFRLTAMTTVAEIVATPLSAMMLESDPWIPFILGTVIMISSSLFVFLMPETLGQMNVNSGIQEDTFERSPEDSEETSQLLPTKNDTIAEIVLGKTQEFILSSKFLWTSPRILISIVAVFAGSMDRSSWYLLIQYVSTKFRWSIAEASYLISVRGCMTLATLLVILPILSSFLSRTLHYAPVTKDLYIARFSAASGVLGYLMVSIASSAPILLMGTLFMSFSIPFVYSVISVATSFVPSQNQIATLYAAMSVSISIGGVVASPMFAGLYAVGMQLGVEWSGLPFAVGSGLLLLTLVPILYIKVQTQLEDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3Z4</accession>
    <name>B8M3Z4_TALSN</name>
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        <recommendedName>
            <fullName evidence="8">CorA family metal ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_039370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002481126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3Z4"/>
    <dbReference type="STRING" id="441959.B8M3Z4"/>
    <dbReference type="GeneID" id="8109275"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_039370"/>
    <dbReference type="eggNOG" id="ENOG502SJAE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027742_0_0_1"/>
    <dbReference type="InParanoid" id="B8M3Z4"/>
    <dbReference type="OMA" id="STMTHIT"/>
    <dbReference type="OrthoDB" id="3231000at2759"/>
    <dbReference type="PhylomeDB" id="B8M3Z4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050829">
        <property type="entry name" value="CorA_MIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47685">
        <property type="entry name" value="MAGNESIUM TRANSPORT PROTEIN CORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47685:SF1">
        <property type="entry name" value="MAGNESIUM TRANSPORT PROTEIN CORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED20737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="51070" checksum="18E966EF5F51F241" modified="2009-03-03" version="1">MIDFPRDNDGEPTQTLINSNEELRRLFQGYDFNHSPDHSRLFVIEDLSRDVIEAFGSAYDIDPFFWRGHISDYLWYNTRDPWVELEELPHITRSRNFYHFRYVHPRYFKSKESQLRATEEARRMNVLRRLDDDRISASMLDDDQASVNMWRSKASLWLRRNERHQKHTLGILVVDPSIKEGHPLWGKGYNFDSPPSLASNLTPAPIPKDSLFEAVIHWTTRVSMQKLKELEEQPNNFAIAILSIIAVEWLTVKEYVTTRLTQIEWELEVPDFRGHGEKYGLDASLKWLHPFRRNVPRYRKWVTNILNGILSDKNLSPSQSKDQALRDLREDFLIILRDLDTLQAQVQDLVRVVTAIISIEEAKRSAEQNRSLARLTYLAVVFVPLSFVSSFFSMTSDVASLRTTFWIFFAVAVPLTLLSLSVTRWWAITRWLRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4C9</accession>
    <name>B8M4C9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA damage response protein RcaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_024480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Nibrin family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479558.1">
        <property type="nucleotide sequence ID" value="XM_002479513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4C9"/>
    <dbReference type="STRING" id="441959.B8M4C9"/>
    <dbReference type="GeneID" id="8097979"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_024480"/>
    <dbReference type="eggNOG" id="ENOG502RCD5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007951_0_0_1"/>
    <dbReference type="InParanoid" id="B8M4C9"/>
    <dbReference type="OMA" id="GIGDHYW"/>
    <dbReference type="OrthoDB" id="552194at2759"/>
    <dbReference type="PhylomeDB" id="B8M4C9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000082">
        <property type="entry name" value="DNA damage response protein RcaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10980">
        <property type="entry name" value="Nibrin, BRCT2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040227">
        <property type="entry name" value="Nibrin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032429">
        <property type="entry name" value="Nibrin_BRCT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043014">
        <property type="entry name" value="Nibrin_BRCT2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162:SF0">
        <property type="entry name" value="NIBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162">
        <property type="entry name" value="NIBRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16508">
        <property type="entry name" value="NIBRIN_BRCT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="7">
        <location>
            <begin position="24"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="362"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="453"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="634"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="399"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="502"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="535"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="634"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="655"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="696"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="723"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED19124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="744" mass="84023" checksum="3E069A278DC327EA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4M1</accession>
    <name>B8M4M1_TALSN</name>
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        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TSTA_025330</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479650.1">
        <property type="nucleotide sequence ID" value="XM_002479605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4M1"/>
    <dbReference type="FunCoup" id="B8M4M1">
        <property type="interactions" value="166"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M4M1"/>
    <dbReference type="GeneID" id="8106750"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_025330"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003731_0_0_1"/>
    <dbReference type="InParanoid" id="B8M4M1"/>
    <dbReference type="OMA" id="WGDSNRI"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="PhylomeDB" id="B8M4M1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005034">
        <property type="term" value="F:osmosensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007234">
        <property type="term" value="P:osmosensory signaling via phosphorelay pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06225">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000004">
        <property type="entry name" value="Ethylene receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000289">
        <property type="entry name" value="Osmosensing histidine protein kinase SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF34">
        <property type="entry name" value="TWO-COMPONENT SYSTEM PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 14" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="18">
        <location>
            <begin position="563"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="19">
        <location>
            <begin position="988"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="744"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="937"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="522"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="940"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="968"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="14">
        <location>
            <position position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EED19216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1118" mass="121363" checksum="1C3724AA20498637" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5J1</accession>
    <name>B8M5J1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_031440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PhylomeDB" id="B8M5J1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
    <dbReference type="CDD" id="cd00067">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED19885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="313" mass="35387" checksum="2625C6719C4D3C9D" modified="2009-03-03" version="1">MEVNYAIPVHLCSLCGKPFTQERQHRRHQAYCRRNQSRLRTRPRSCRACNQAKIKCNFRDPCNQCTRKGLDCVYEPSRKEPVANDAPITISDFWASHSTHGLEQVSTSNLLGHGLDRDSLGLLRPGDMPDLDSDGLFTMPATEFNWGGSRHKEISSVGDLQMPTTFSSDLDTYMSLLQSDDLDLTSDTSTSKTLDLILPAQVSTPLSIPSTEISTTRVHFSRNKIVTPAQQLFTSMLVDMIRAYPLMMTRRETFPPFVHPHCYLYEGCDTFPQVLTNCMGIAQLFVSRTDDTRPFVWTTVMAEVRSVLTKVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5L2</accession>
    <name>B8M5L2_TALSN</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_031660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480340.1">
        <property type="nucleotide sequence ID" value="XM_002480295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5L2"/>
    <dbReference type="STRING" id="441959.B8M5L2"/>
    <dbReference type="GeneID" id="8107776"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_031660"/>
    <dbReference type="eggNOG" id="ENOG502SBBS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016543_0_0_1"/>
    <dbReference type="InParanoid" id="B8M5L2"/>
    <dbReference type="OMA" id="MLWRWSH"/>
    <dbReference type="OrthoDB" id="3439035at2759"/>
    <dbReference type="PhylomeDB" id="B8M5L2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="737"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="858" mass="95088" checksum="7AF390C1309B6468" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5X7</accession>
    <name>B8M5X7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar import and degradation protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_033470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480538.1">
        <property type="nucleotide sequence ID" value="XM_002480493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5X7"/>
    <dbReference type="STRING" id="441959.B8M5X7"/>
    <dbReference type="GeneID" id="8105085"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_033470"/>
    <dbReference type="eggNOG" id="KOG4635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022561_1_0_1"/>
    <dbReference type="InParanoid" id="B8M5X7"/>
    <dbReference type="OMA" id="GAMNISH"/>
    <dbReference type="OrthoDB" id="432381at2759"/>
    <dbReference type="PhylomeDB" id="B8M5X7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED20104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="70147" checksum="E8E3D81A53B963D9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6A1</accession>
    <name>B8M6A1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_025910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479710.1">
        <property type="nucleotide sequence ID" value="XM_002479665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6A1"/>
    <dbReference type="STRING" id="441959.B8M6A1"/>
    <dbReference type="GeneID" id="8108003"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_025910"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_891675_0_0_1"/>
    <dbReference type="InParanoid" id="B8M6A1"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="PhylomeDB" id="B8M6A1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="335" mass="38969" checksum="75859B042530C4C3" modified="2009-03-03" version="1">MDAPFPHQHSARKLDGFENAGHLNEHWSSRVYPAINLLNPEVEVYNSPTGERICTRCCVSYCCRNLYLLHVELSLEHNLCVLCNYKTDFDRFEDLQEHTERDHFWCEICNWYAPSYEGLQQHFKHWHNMCEICKQTFNNQSELISHGNTHRPMCVPCIMCGEKFNLRSASFNHMESGKCPSGATKGDIRFVVRNFWDHLCMELGYWVPDTHLFHCQTCQRYYQRLSDLFQHRESKSCREGYCKVNSITERLMNYLQEQLPLVVEARKKQEESEKKRLEAVYSAPSTPSALAVASVPADLLAPPVLPAHPRILKLRGEPGKLHNELQLVCKGPREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6M0</accession>
    <name>B8M6M0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase III subunit RPC9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_027750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002479871.1"/>
    </dbReference>
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    <dbReference type="STRING" id="441959.B8M6M0"/>
    <dbReference type="GeneID" id="8109694"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_027750"/>
    <dbReference type="eggNOG" id="ENOG502RMXH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071855_0_0_1"/>
    <dbReference type="InParanoid" id="B8M6M0"/>
    <dbReference type="OMA" id="GNWAPSP"/>
    <dbReference type="OrthoDB" id="1746530at2759"/>
    <dbReference type="PhylomeDB" id="B8M6M0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038846">
        <property type="entry name" value="RPC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561">
        <property type="entry name" value="CALCITONIN GENE-RELATED PEPTIDE-RECEPTOR COMPONENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="23031" checksum="1E9FE1C2FA1E2A77" modified="2009-03-03" version="1">MKIVDPQTATLTNIEVLAYLTANPPRKSPEAPPGVRNYIPKPDLRDHCTVVTEIHNYVERISPHLLDYPRYTHDPNTNPTTHTLQQPSTDQQKPYIQPTEPTPLDNALRKVIHELAPYNLTKGEVMMLINLGVGIKKKRKTDDDGDQAMDVNGEQQQAGNGEEDDLFSDTVLINSIVEEMDDRLNEEDMRNIFKIMNDSLGCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6M1</accession>
    <name>B8M6M1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_027760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002479872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6M1"/>
    <dbReference type="GeneID" id="8109695"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_027760"/>
    <dbReference type="eggNOG" id="ENOG502SKSW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020425_3_1_1"/>
    <dbReference type="InParanoid" id="B8M6M1"/>
    <dbReference type="OMA" id="LLGGQDW"/>
    <dbReference type="OrthoDB" id="422736at2759"/>
    <dbReference type="PhylomeDB" id="B8M6M1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22997">
        <property type="entry name" value="GT_LH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587:SF2">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="503" mass="57441" checksum="BDE89298A3C63449" modified="2009-03-03" version="1">MILDYPPLTLLRPKPESRKGATAKQAAVEKVESMLTFLKTNKRIRERDLLLIVDSKDTVFQLPSDVLINRYLEITRRKNEHLKSKYGTKVIVDPENESNRWVVPKYTQKALFASRKDCSSNVTDGAACASVPQSPLPPDIYGPKTDKKRDGTLNRPRWIESGAVMGQTSDLIPIYERVLEEMKKQPLRANEQLIFTNMFGAQEYSREIERRKTGSPLKDWVWDYMGILDSTNVTGVRAHIQPGSRHEFGMGLDYEGQLFLSTRKTLGDIEWLRYRDSRKVSSVQIQHGVPREVRLNLPLDIEQNPLNPFKKVKLSSSLSSKTANMTSIDVLPPSWNFTWNDLPLVTYIQTAAVPAIIHTSGETSVRQTFWLNSWFHPWARALLRNYLRSAPKIQPGRQISTLGATDLLKHPDRKGGMWTDNDEWMSFEDLCSGLETPMFDDELGPWGNEKPSALRAVYNLWGKLMAGKGRKYVKLGEMGSEAEEIERFILGVDEDEEEDPELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B8M816</accession>
    <name>B8M816_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Forkhead transcription factor Fkh1/2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_032340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480412.1">
        <property type="nucleotide sequence ID" value="XM_002480367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M816"/>
    <dbReference type="FunCoup" id="B8M816">
        <property type="interactions" value="1678"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M816"/>
    <dbReference type="GeneID" id="8099847"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_032340"/>
    <dbReference type="eggNOG" id="KOG2294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007090_1_0_1"/>
    <dbReference type="InParanoid" id="B8M816"/>
    <dbReference type="OMA" id="EKYAFYR"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="PhylomeDB" id="B8M816"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20024">
        <property type="entry name" value="FH_FOXJ2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22701">
        <property type="entry name" value="FHA_FKH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000030">
        <property type="entry name" value="Forkhead box protein K2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000039">
        <property type="entry name" value="Forkhead transcription factor Fkh1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF1">
        <property type="entry name" value="FORK HEAD PROTEIN HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="126"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Fork-head" evidence="9">
        <location>
            <begin position="352"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="352"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="440"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="645"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="478"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="542"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="567"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="680"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="697"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="720"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED19978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="732" mass="80350" checksum="D4A4CFA5E7EDF583" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8M825</accession>
    <name>B8M825_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein EFR3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_032430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480421.1">
        <property type="nucleotide sequence ID" value="XM_002480376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M825"/>
    <dbReference type="STRING" id="441959.B8M825"/>
    <dbReference type="GeneID" id="8099856"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_032430"/>
    <dbReference type="eggNOG" id="KOG1877">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003271_0_0_1"/>
    <dbReference type="InParanoid" id="B8M825"/>
    <dbReference type="OMA" id="ATHVYYT"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="PhylomeDB" id="B8M825"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039786">
        <property type="entry name" value="EFR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049150">
        <property type="entry name" value="EFR3_HEAT-like_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766:SF1">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21072">
        <property type="entry name" value="EFR3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="812"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="904"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="943"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1094"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="817"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="838"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="920"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="967"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1001"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1035"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1053"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1096"/>
            <end position="1110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1125" mass="122485" checksum="F13939DFA3BC5FC2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8F2</accession>
    <name>B8M8F2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-CoA dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_036860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480899.1">
        <property type="nucleotide sequence ID" value="XM_002480854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8F2"/>
    <dbReference type="STRING" id="441959.B8M8F2"/>
    <dbReference type="GeneID" id="8100532"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_036860"/>
    <dbReference type="eggNOG" id="KOG0137">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016513_1_1_1"/>
    <dbReference type="InParanoid" id="B8M8F2"/>
    <dbReference type="OMA" id="IEMVAMT"/>
    <dbReference type="OrthoDB" id="10251155at2759"/>
    <dbReference type="PhylomeDB" id="B8M8F2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052904">
        <property type="entry name" value="Acyl-CoA_dehydrogenase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707:SF2">
        <property type="entry name" value="ACD11 DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="6">
        <location>
            <begin position="190"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="5">
        <location>
            <begin position="306"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED20465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="608" mass="67138" checksum="9D3B98D98AB21BD3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8M933</accession>
    <name>B8M933_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-beta hydroxysteroid dehydrogenase/isomerase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_111640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481320.1">
        <property type="nucleotide sequence ID" value="XM_002481275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M933"/>
    <dbReference type="STRING" id="441959.B8M933"/>
    <dbReference type="GeneID" id="8098819"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_111640"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="InParanoid" id="B8M933"/>
    <dbReference type="OMA" id="KPYGSAM"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="PhylomeDB" id="B8M933"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED17328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="346" mass="37710" checksum="028A37686B3DA817" modified="2009-03-03" version="1">MIMAGDLILITGVSGYIGFKTLILALEAGFPVRAVIRKAEQATKLQSHARVAPHMDNLQWVVIPDLSDTHSFDPHLAGVTGILHIASPPAIESDDYDRDIINPALKVTLSILNAAHRTPSIKRVVITSSAVTLISFAWMFGPAPASPDLTLFTAADINSNIAGPYGTSMEAYFASKTLSRIATKKFMEEEKPEFEFVNLLPTVVFGPDELATNAAELVTSGNSLALGPLLDANIPQMVGATVHVDDVARAHIDALKPSVQGNKDYILSSDAPDGIDWEDAQNYVTKFFPEAVENGTLKLGGSLRARIWRLDTRETEKEFGWEFVSFKETLKELVGQYLKFVAAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8M949</accession>
    <name>B8M949_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_111800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481336.1">
        <property type="nucleotide sequence ID" value="XM_002481291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M949"/>
    <dbReference type="STRING" id="441959.B8M949"/>
    <dbReference type="GeneID" id="8098835"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_111800"/>
    <dbReference type="eggNOG" id="ENOG502S1RM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_12_3_1"/>
    <dbReference type="InParanoid" id="B8M949"/>
    <dbReference type="OMA" id="AWRPAHE"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="PhylomeDB" id="B8M949"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF3">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="316" mass="34676" checksum="7C9715A0F8ACE013" modified="2009-03-03" version="1">MPRILILGATGYIGRRVASRLIESVRTQEKALQLQKEEIIPVLCADPVSNPEPYLATVRSSSIDIVIDVSGANKQSHAFLNDLKRLGQERIESYRKRGIANGPKLGFIYCSGTWVHGSSNRPVTDLDLVGPDSMTAPQELVAWRVKLEDEVIASNDILDAMVLRPALIYGRESTIWSPFFTPVLEAARNKIESPIEIPLEAQSKPGLVHIDDVATAFQNAVEKLPIIAGANVYPVFDLVTSQESMREVFDAVGACFGYAGVIQLKGHGDDLFAKAMSTTFRGTSARAELLLGWRPRRRGGFVKDMDIYCMAFAAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9A5</accession>
    <name>B8M9A5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_114720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481657.1">
        <property type="nucleotide sequence ID" value="XM_002481612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9A5"/>
    <dbReference type="STRING" id="441959.B8M9A5"/>
    <dbReference type="GeneID" id="8101282"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_114720"/>
    <dbReference type="eggNOG" id="ENOG502SD1F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015711_1_0_1"/>
    <dbReference type="InParanoid" id="B8M9A5"/>
    <dbReference type="OMA" id="TQWNVAT"/>
    <dbReference type="OrthoDB" id="10003116at2759"/>
    <dbReference type="PhylomeDB" id="B8M9A5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="583" mass="62928" checksum="55FCE0E117A83122" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9E0</accession>
    <name>B8M9E0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_115020</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481692.1">
        <property type="nucleotide sequence ID" value="XM_002481647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9E0"/>
    <dbReference type="FunCoup" id="B8M9E0">
        <property type="interactions" value="164"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M9E0"/>
    <dbReference type="GeneID" id="8101312"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_115020"/>
    <dbReference type="eggNOG" id="KOG1260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019214_2_2_1"/>
    <dbReference type="InParanoid" id="B8M9E0"/>
    <dbReference type="OMA" id="YVSGWQV"/>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="PhylomeDB" id="B8M9E0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.850:FF:000001">
        <property type="entry name" value="Isocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF3">
        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="8 10 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="99"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="209"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="425"/>
            <end position="429"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED17700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="540" mass="60575" checksum="13B1E36512A6D612" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9Q3</accession>
    <name>B8M9Q3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SGT1 and CS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_118250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SGT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482047.1">
        <property type="nucleotide sequence ID" value="XM_002482002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9Q3"/>
    <dbReference type="FunCoup" id="B8M9Q3">
        <property type="interactions" value="1019"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M9Q3"/>
    <dbReference type="GeneID" id="8099749"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_118250"/>
    <dbReference type="eggNOG" id="KOG1309">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039532_3_1_1"/>
    <dbReference type="InParanoid" id="B8M9Q3"/>
    <dbReference type="OMA" id="KSGPKNW"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="PhylomeDB" id="B8M9Q3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06466">
        <property type="entry name" value="p23_CS_SGT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044563">
        <property type="entry name" value="Sgt1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45862">
        <property type="entry name" value="PROTEIN SGT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05002">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="4">
        <location>
            <begin position="237"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="3">
        <location>
            <begin position="368"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="354"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED18055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="478" mass="51863" checksum="D4F69808A2AC1C79" modified="2009-03-03" version="1">MNAATQGDKAASLSDWPSAITHYTNALIELPRAPSYYIKRSTAYSRRKTVDGGPDLQAALRDVELALALARERGKRELIIEAQLRRAIVFFQLERYGDAGFLFDLLEENVGKKDGAGGDKSVQVKAAMSAQKGSQQKLENELSIWRLKIKGKIGKLEGNDEKLAVTVREYPDIKIPSEEELRKRLKDQFSSTNTEVASAANRTTESTLAVSGSTSAAPPFTAGPGAPTTTPAPVSAPAKIRHEWYQSQDSVVVTIYAKNVDKSKLETELQENILSLEFPLPSGSTYSFTLDPLYAPIDTTQSKVNVLSTKIEITLCKRTPGQKWGALECSATAPVLSNPANTVTVNSTAAVPITQTPTQINNNTGGPAYPTSSKHGVKNWDKLADDLTAKKKKKDEKKKSGEAPNGEEDDDDDTASIDSDFGGGDAVDSFFKKLYAGSDPDTRRAMVKSFYESQGTALSTNWDEVGKEKVPVHPPSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9X3</accession>
    <name>B8M9X3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_118890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482117.1">
        <property type="nucleotide sequence ID" value="XM_002482072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9X3"/>
    <dbReference type="STRING" id="441959.B8M9X3"/>
    <dbReference type="GeneID" id="8108563"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_118890"/>
    <dbReference type="eggNOG" id="ENOG502RW67">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1582316_0_0_1"/>
    <dbReference type="InParanoid" id="B8M9X3"/>
    <dbReference type="OMA" id="QHEYPIL"/>
    <dbReference type="OrthoDB" id="4509917at2759"/>
    <dbReference type="PhylomeDB" id="B8M9X3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="30"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED18125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="197" mass="22591" checksum="ED8F3ABEAF3C490D" modified="2009-03-03" version="1">MALALQLPFQPEANTNDEPTPYLGSSPTKPCSPRVFWKENENNFPVLARLVRDVLTVPATGSGVERLFNSARDICHYCRGSLKSRTIQDLVIFMCTSRLEIESEQLALLEEYISTQEIQTRTEENAANKAAPMVDMEEEEDEDEEGNEEDEIPLPDNTRLHDQNSTQRRKSGRVTKRSKQDDSQWEYLMPQIEQIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAT3</accession>
    <name>B8MAT3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_115680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481765.1">
        <property type="nucleotide sequence ID" value="XM_002481720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAT3"/>
    <dbReference type="STRING" id="441959.B8MAT3"/>
    <dbReference type="GeneID" id="8099595"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_115680"/>
    <dbReference type="HOGENOM" id="CLU_1090326_0_0_1"/>
    <dbReference type="InParanoid" id="B8MAT3"/>
    <dbReference type="OMA" id="FRICKST"/>
    <dbReference type="OrthoDB" id="4662630at2759"/>
    <dbReference type="PhylomeDB" id="B8MAT3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877501" evidence="1">
        <location>
            <begin position="19"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="278" mass="29132" checksum="94E490DFC8059A75" modified="2009-03-03" version="1">MKAFYSFPLLFLPSLVSATPSDLTTIELDKRACTPFKNPLTNASGCCDIVSAQLFWVDILLGIGVCCPIGQVLEGFNCVTPSSGGSVCSGKAVCANKTGVDLGIKYGHCYVLLSLNNNYLGHDNALKYVVMGENPGVVFRVCGDTTTCTTSADQYVPVNGTWYMQDQMGDPNGSGFAWLGGAGDLNIVNSTDQALAMGGSSTCFGGNCAICITFPPGGAHAPCPLTPGQSHLGIAANPNSCQNFYWQEVSCRSENQLAECQISPSTAKSESVGYVAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBA1</accession>
    <name>B8MBA1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_126010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482882.1">
        <property type="nucleotide sequence ID" value="XM_002482837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBA1"/>
    <dbReference type="STRING" id="441959.B8MBA1"/>
    <dbReference type="GeneID" id="8098113"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_126010"/>
    <dbReference type="eggNOG" id="ENOG502S50U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058846_1_0_1"/>
    <dbReference type="InParanoid" id="B8MBA1"/>
    <dbReference type="OMA" id="GKRITWV"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="PhylomeDB" id="B8MBA1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01135">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED18890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="293" mass="31794" checksum="3BF82C6567461F6A" modified="2009-03-03" version="1">MSTQLDAAAIARVSLHDPTHFSIQHSQTVHRLVLLQHWNIPADSKVLELGCGQGDCTTALASAVGEQGRVVAVDPAELDYGAPYTLGQAQSYISQGPLGNRIIWVRQPPLDYLSSLPSPHSSESKAFDATVLAHCLWYFASPELILSTFRALKQHSKRLLLAEWSLVATHPSAQPHVLAALTQAALECRKPNSVSNVRTVLGPKRLTELALAAGWQVESETRVPGREGLLDGQWEVSACLSSSFEQEVEEQVSDERERAVVLASRDACEASLDGIQGGRKGVKAMDVWVASFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCS3</accession>
    <name>B8MCS3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">O-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_126830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482967.1">
        <property type="nucleotide sequence ID" value="XM_002482922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCS3"/>
    <dbReference type="STRING" id="441959.B8MCS3"/>
    <dbReference type="GeneID" id="8099110"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_126830"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_11_0_1"/>
    <dbReference type="InParanoid" id="B8MCS3"/>
    <dbReference type="OMA" id="LLACIQW"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="PhylomeDB" id="B8MCS3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF15">
        <property type="entry name" value="MONODICTYPHENONE CLUSTER TRANSCRIPTIONAL COACTIVATOR MDPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED18975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="48243" checksum="27F646E6FB6A82DC" modified="2009-03-03" version="1">MTDLLQLEVHARELLTSLNHFSTHRQDDRSTLSPPEELELSDSARESALATIAKIQVILSGPSDFIHQMTTQTQILACMRWMGEFHVLAYIPQDGSALMKDISDLINVSESQLCRIIRMVTPMGFLKEPQPGYVAHSALSASFASKQSYVDAMMFLANTLAPAALGMATAQHDSEYHEHARNSLCNHESAISTTFSSIDKTQLPLLQRRWHAYLRHGMGYFCDTATDILTCLEPFRMEKALIVEVGARSTERATILAKLYPMLHITVQLRPTCSTSGKNRVTASNVDRMRPPRITILDRVPGSPQPIQDAAVYIINLPLPDPGMPPSPLAMQIRAEMMAHLNTLRTNRSATMVLVVPSLSDCGAESGKSVSLAGIRDFSLLQLANEREMRLTEIIDLLHKMSDSEGRLVLVNKVISAGRYGIVGLEVKYQAYADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCU0</accession>
    <name>B8MCU0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_127000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482984.1">
        <property type="nucleotide sequence ID" value="XM_002482939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCU0"/>
    <dbReference type="STRING" id="441959.B8MCU0"/>
    <dbReference type="GeneID" id="8099127"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_127000"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001650_6_0_1"/>
    <dbReference type="InParanoid" id="B8MCU0"/>
    <dbReference type="OMA" id="HINTRYH"/>
    <dbReference type="OrthoDB" id="4356562at2759"/>
    <dbReference type="PhylomeDB" id="B8MCU0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF438">
        <property type="entry name" value="REVERSE TRANSCRIPTASE TY1_COPIA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED18992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="27137" checksum="1C126059AE7A3A81" modified="2009-03-03" version="1">MDTPISGNIEASKGEATNQEIHAYQELVESALYASIMTRIDIAKAVNELAKYTKNPSIAHFQQIRRVIQYLYNTRFLAIEFSPPQNPKKDAFICASDASFGDNPDHTSSKGYLVQIYGGSVDWRATKQRLVTTSTTKAELRAATKAAKRLQVWKRVFRSIGFKPDRELSIQCDNKQTVALLTSEEPQFRTNLKHVDIYHHWLRQEISKKRLRIEWVDTKRMAADGLTKILRGHLTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCW2</accession>
    <name>B8MCW2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_113140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481480.1">
        <property type="nucleotide sequence ID" value="XM_002481435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCW2"/>
    <dbReference type="STRING" id="441959.B8MCW2"/>
    <dbReference type="GeneID" id="8101626"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_113140"/>
    <dbReference type="eggNOG" id="ENOG502SK48">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011581_0_2_1"/>
    <dbReference type="InParanoid" id="B8MCW2"/>
    <dbReference type="OMA" id="EHETISY"/>
    <dbReference type="OrthoDB" id="4222536at2759"/>
    <dbReference type="PhylomeDB" id="B8MCW2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF7">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="4"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="587"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED17488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="680" mass="76357" checksum="D400BF034E6A9747" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCY7</accession>
    <name>B8MCY7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_113390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481505.1">
        <property type="nucleotide sequence ID" value="XM_002481460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCY7"/>
    <dbReference type="STRING" id="441959.B8MCY7"/>
    <dbReference type="GeneID" id="8101651"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_113390"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_0_1"/>
    <dbReference type="InParanoid" id="B8MCY7"/>
    <dbReference type="OMA" id="QKKFRCE"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="PhylomeDB" id="B8MCY7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963">
        <property type="entry name" value="CARBONYL REDUCTASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963:SF6">
        <property type="entry name" value="CHAIN DEHYDROGENASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED17513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="295" mass="31655" checksum="EC68E31D8E7DA5B9" modified="2009-03-03" version="1">MSTKEIVLITGGNRGIGYGVARKLSREYSNFHVIIGSRDANQGREAVSSLLAEEGLSGSSISSVELDVTSDESISAAKKTIEEQHGRLDVLINNAGIALDVKEKGKLPLRTIMQRTYDVNVIGAALVTEIFVPLLEKSANPRIVFVSSEIGSLTSAADPSTPWFKDPFLAYKSSKSSLNMVMLWYNALLAEKGFKVNAACPGYVATNLNSFHGTGTVEDGAVNIVRLAVLGKDGETGTFSAKEAVSRRLIDISNLAVPFNSSKSLCRCRPMTGMPHFTIHSILIAFVDIILSEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MD39</accession>
    <name>B8MD39_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_127100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED19002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482994.1">
        <property type="nucleotide sequence ID" value="XM_002482949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MD39"/>
    <dbReference type="STRING" id="441959.B8MD39"/>
    <dbReference type="GeneID" id="8099137"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_127100"/>
    <dbReference type="eggNOG" id="KOG0351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004144_0_0_1"/>
    <dbReference type="InParanoid" id="B8MD39"/>
    <dbReference type="OMA" id="HISEEWH"/>
    <dbReference type="OrthoDB" id="5153301at2759"/>
    <dbReference type="PhylomeDB" id="B8MD39"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF154">
        <property type="entry name" value="RECQ HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="628"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="820"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="993"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="996"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1010"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED19002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1198" mass="136941" checksum="3DB95C714975F6D6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEA4</accession>
    <name>B8MEA4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_016110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483765.1">
        <property type="nucleotide sequence ID" value="XM_002483720.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483766.1">
        <property type="nucleotide sequence ID" value="XM_002483721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEA4"/>
    <dbReference type="STRING" id="441959.B8MEA4"/>
    <dbReference type="GeneID" id="8106384"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_016110"/>
    <dbReference type="eggNOG" id="ENOG502SIHY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043294_0_0_1"/>
    <dbReference type="InParanoid" id="B8MEA4"/>
    <dbReference type="OMA" id="GSWHVSW"/>
    <dbReference type="OrthoDB" id="5344482at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="367" mass="39830" checksum="70F40E6BE55F12C9" modified="2009-03-03" version="1">MSQRTFAAIDDSLSLETPRVSGSSTLSISALARFEFEAGKGNDGTKILMVEWEDDDISRSSTGSWHVSWEGKTTVLPADEQTTENTNRFYFLLPPKTTVPPVIDLTYTPHPESASTVRQPESIQINPLPAIFPPELGATARTAGKKGVLHTIWAKKRLQVLDNEIKSESATNVEGIALQMAIQEKEWIEENYGVSSPPSVIQKASSSDQAIFSTPSSPLTMVSPGGSRSLGEKLKGLRLDTSETTPSKRSEDYKSDGSGQTGDTDRYHLLSPQTRDVAVSSFSAFSHVSQPDNEVQSYVAHNPPASIQKAQSNAGDFVFMSTLTRTESTDSADGLFAKALSPRTPDLPVSPFSFSRSDTMAYVSNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEH3</accession>
    <name>B8MEH3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_016750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483834.1">
        <property type="nucleotide sequence ID" value="XM_002483789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEH3"/>
    <dbReference type="STRING" id="441959.B8MEH3"/>
    <dbReference type="GeneID" id="8103648"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_016750"/>
    <dbReference type="eggNOG" id="ENOG502S3M7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042560_0_0_1"/>
    <dbReference type="InParanoid" id="B8MEH3"/>
    <dbReference type="OMA" id="MSYGNNG"/>
    <dbReference type="OrthoDB" id="5399305at2759"/>
    <dbReference type="PhylomeDB" id="B8MEH3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="33369" checksum="84F7326BEF5780DE" modified="2009-03-03" version="1">MEQREYRVHKHHRRVSSTGGGRAWTEEEEAYLVRTRMHKMPYKHIAAHLKKTELACRLHYHQMSYGNNGRRRSASVSSIGSFNSVSPGGELSDNTRLPRLSPVLSPRSSPEPNSQRVSSDDASPQSHRGPIPILPKPDRDNTPTTFEISMARSYETNVVGYRKEDQQSYIDMSHLHAVYEAYSASFWSKIATEYSRAAPEISPKLAEKAFMGNFSHTIACAHLPPTPNVSPAASPEPQQRDYASNSLPPMSRGFRAVNEPQPERAAGVQPESTHRSLADRCSVSALLTVEREVRPSHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8MF35</accession>
    <name>B8MF35_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_012430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483368.1">
        <property type="nucleotide sequence ID" value="XM_002483323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MF35"/>
    <dbReference type="STRING" id="441959.B8MF35"/>
    <dbReference type="GeneID" id="8104091"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_012430"/>
    <dbReference type="eggNOG" id="ENOG502SJYB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023878_0_2_1"/>
    <dbReference type="InParanoid" id="B8MF35"/>
    <dbReference type="OMA" id="REGACAY"/>
    <dbReference type="OrthoDB" id="4503105at2759"/>
    <dbReference type="PhylomeDB" id="B8MF35"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED16134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="254" mass="28445" checksum="99F8B32FA020B0D7" modified="2009-03-03" version="1">MHEKFVRADAHAFKEKQITESVISMIEGDNGDARCIAGGIPFRNLNHLIDGTLVLGNPDRYYGARPEQLNRRIRSELEDQIVLSTQHDLPIAPNFFLAAKGPDGSASVAKRQASYDGALGARRMHSLQEYGKDEPEFDNNAYTISSIYHDGTLKMFTNNPRTFQEGATWYQNGRDWAKEQRDEAIRRANEKVTQNDIRSSAVNTSFSTVCEISSTESIASITEQSYFSFSGTNTIETHSLQSTRSLSPKPSQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFA3</accession>
    <name>B8MFA3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_013080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483436.1">
        <property type="nucleotide sequence ID" value="XM_002483391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFA3"/>
    <dbReference type="GeneID" id="8108184"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_013080"/>
    <dbReference type="HOGENOM" id="CLU_1305600_0_0_1"/>
    <dbReference type="InParanoid" id="B8MFA3"/>
    <dbReference type="OrthoDB" id="4216719at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877574" evidence="1">
        <location>
            <begin position="23"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="211" mass="23726" checksum="A5CBE53D53D4E83E" modified="2009-03-03" version="1">MNLTITKLGMAWMAIALEAVAAILLAANATEDPMEIQSEFHSSRAGSDDNMIHWARLLTKLNFDPLIIAILSVKGKNKYSDRVEKFRKLAQETVFNLDDLKSGQDRCFWRLSHEYLGTINDFENSRPMKVPRKAYINHQLSPEIVIGMHALDSIGSAYMRCDGAAWLDDAGMDAHIGSALPNDVVYLHTDIHTGETRNTIRLFYPDELSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8MG34</accession>
    <name>B8MG34_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Efflux pump antibiotic resistance protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_010190</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483135.1">
        <property type="nucleotide sequence ID" value="XM_002483090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MG34"/>
    <dbReference type="FunCoup" id="B8MG34">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="GeneID" id="8102815"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_010190"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="InParanoid" id="B8MG34"/>
    <dbReference type="OMA" id="FSDIGWY"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="PhylomeDB" id="B8MG34"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000489">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="302"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="466"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="545"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="76"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED15901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="582" mass="62169" checksum="6DE8C4491645608B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MG75</accession>
    <name>B8MG75_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_010590</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
            <location evidence="2 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CGR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483176.1">
        <property type="nucleotide sequence ID" value="XM_002483131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MG75"/>
    <dbReference type="STRING" id="441959.B8MG75"/>
    <dbReference type="GeneID" id="8109832"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_010590"/>
    <dbReference type="eggNOG" id="ENOG502S7VB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125051_0_0_1"/>
    <dbReference type="InParanoid" id="B8MG75"/>
    <dbReference type="OMA" id="NGKQWHD"/>
    <dbReference type="OrthoDB" id="3942380at2759"/>
    <dbReference type="PhylomeDB" id="B8MG75"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005579">
        <property type="entry name" value="Cgr1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03879">
        <property type="entry name" value="Cgr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BZIP" evidence="10">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="54"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="54"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED15942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="114" mass="13704" checksum="46A500165409003C" modified="2009-03-03" version="1">MSAVEVADSGKTAVGMRKNGKNWHTPKKPFRPTAGLKSYEKRLEERNNLAAMKEREKEMKEEKEAERQRHIQAIKDRRAAKEEKERYEKMAEKMHRKRVERKKRREKRNKLLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGH1</accession>
    <name>B8MGH1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="18">ABC transporter (Adp1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSTA_013900</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483525.1">
        <property type="nucleotide sequence ID" value="XM_002483480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGH1"/>
    <dbReference type="FunCoup" id="B8MGH1">
        <property type="interactions" value="330"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MGH1"/>
    <dbReference type="GeneID" id="8099189"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_013900"/>
    <dbReference type="eggNOG" id="KOG0061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_57_1_1"/>
    <dbReference type="InParanoid" id="B8MGH1"/>
    <dbReference type="OMA" id="FNCQLDA"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="PhylomeDB" id="B8MGH1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000702">
        <property type="entry name" value="ABC transporter (Adp1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF2">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002875093" evidence="15">
        <location>
            <begin position="22"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="832"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="865"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="922"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="948"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="975"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1061"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="77"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="370"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="669"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="676"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="691"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="722"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EED16291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1087" mass="119752" checksum="B4BAA5B48EBD0B56" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGQ0</accession>
    <name>B8MGQ0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_018680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484035.1">
        <property type="nucleotide sequence ID" value="XM_002483990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGQ0"/>
    <dbReference type="STRING" id="441959.B8MGQ0"/>
    <dbReference type="GeneID" id="8100978"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_018680"/>
    <dbReference type="eggNOG" id="ENOG502RNFM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_14_0_1"/>
    <dbReference type="InParanoid" id="B8MGQ0"/>
    <dbReference type="OrthoDB" id="4368338at2759"/>
    <dbReference type="PhylomeDB" id="B8MGQ0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="44"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED16801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="434" mass="50599" checksum="2B288E69B16B5464" modified="2009-03-03" version="1">MTPKLYKEEEELIAKALSAKLSREYGVSRKKLSRRWHGLPSRSTRPPTRRLLSLDQEKALILWIEYLDNIGAHPTNQQIEESANYLLGKDFRGPGEPPRAGKNWVHDFIKRLPKQYVRIVQKPQEKERTVAEHYGEVERWFIDLELAIQQYKIRPQNLWNFDETGFIVGQGKDEAVVTAYPKTSKRVSSLSSRESITIIEGINAEGKIIPPLLIPKGKVHLEEWYRHIKDDDWLVAPASNGFITDEIAFEWLQHFDHFSRPGAFPDWRLLLMDNHTTHLTIQFVQYCEIWHIRPFRFPPHSTHFLQPLDGVPFQQYKHVHGRVVNKIARLGGFDFDKNDFFEELRDIRIKTFTTRTIRHGWRERGIWPLNPRLILDTMLQPDEAFEALVAEGDALKIYGEADDTIPSSPTTKSISPPSTAVKLRRYVNKIEKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGT6</accession>
    <name>B8MGT6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">D-aminopeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_014130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S58 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483551.1">
        <property type="nucleotide sequence ID" value="XM_002483506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGT6"/>
    <dbReference type="MEROPS" id="P01.003"/>
    <dbReference type="GeneID" id="8099212"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_014130"/>
    <dbReference type="eggNOG" id="ENOG502QRNQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024709_0_0_1"/>
    <dbReference type="InParanoid" id="B8MGT6"/>
    <dbReference type="OMA" id="MRCHGYK"/>
    <dbReference type="OrthoDB" id="2107894at2759"/>
    <dbReference type="PhylomeDB" id="B8MGT6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.70.12">
        <property type="entry name" value="L-amino peptidase D-ALA esterase/amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005321">
        <property type="entry name" value="Peptidase_S58_DmpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512:SF3">
        <property type="entry name" value="BLR5678 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512">
        <property type="entry name" value="D-AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03576">
        <property type="entry name" value="Peptidase_S58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="DmpA/ArgJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="42074" checksum="96CC4AE6873B8B73" modified="2009-03-03" version="1">MSSRPRIRDLGYSPGRFKTGVKNSLLDVEGVAVGQSTIHRGQDIHTGVTVILPRGIKNTRYLPCYAATHDLNGMGEMTGTHGLTEWGFISGPIALTNTVSIGKVYDALFLWQLEQGALAGDNEVEVMRRVSIPVVGETFDGLLNDISASVIDKHVVYDAIEASKTQSDVLEGNYGGGTAMRCHGYKGGTGTSSRIVPGVDKDYTLGVLVQANHGQKDDLRIGNVPVGEFLVREEARAAAEEKGTQFPKGGKAAEGSLLVVIITDAPLLPHQLRRIAQHAGMGVTQVGGHAAGRNFSGEIFLALSTGASPNELATSSSGFDYLPPLETQPVETLKNEVIDSLFYATSEATEEAILNAMCKAEPLTGYKGRSQAALPVDRVKELLDKYMVKFEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGZ5</accession>
    <name>B8MGZ5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_014680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483610.1">
        <property type="nucleotide sequence ID" value="XM_002483565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGZ5"/>
    <dbReference type="GeneID" id="8107851"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_014680"/>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011099_0_1_1"/>
    <dbReference type="InParanoid" id="B8MGZ5"/>
    <dbReference type="OMA" id="EYRFSNC"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="PhylomeDB" id="B8MGZ5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF2">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="287"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="613"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="635"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED16376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="755" mass="85516" checksum="240A1808D06725AF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHB5</accession>
    <name>B8MHB5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="14">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSTA_021510</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Interacts with the MHF histone-fold complex to form the FANCM-MHF complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="14"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484328.1">
        <property type="nucleotide sequence ID" value="XM_002484283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHB5"/>
    <dbReference type="FunCoup" id="B8MHB5">
        <property type="interactions" value="215"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MHB5"/>
    <dbReference type="GeneID" id="8098417"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_021510"/>
    <dbReference type="eggNOG" id="KOG0354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002513_0_0_1"/>
    <dbReference type="InParanoid" id="B8MHB5"/>
    <dbReference type="OMA" id="FMMRAIF"/>
    <dbReference type="OrthoDB" id="164902at2759"/>
    <dbReference type="PhylomeDB" id="B8MHB5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18033">
        <property type="entry name" value="DEXDc_FANCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12091">
        <property type="entry name" value="FANCM_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18801">
        <property type="entry name" value="SF2_C_FANCM_Hef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001992">
        <property type="entry name" value="ATP-dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000861">
        <property type="entry name" value="Fanconi anemia, complementation group M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1320.20">
        <property type="entry name" value="hef helicase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like_ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044749">
        <property type="entry name" value="FANCM_DEXDc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025">
        <property type="entry name" value="FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="FANCONI ANEMIA GROUP M PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="283"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="626"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="105"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="187"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="807"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="973"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1074"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="228"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="824"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="973"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="985"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1004"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1020"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1088"/>
            <end position="1101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EED17094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1101" mass="123222" checksum="1C1E396D2789F6EF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHN6</accession>
    <name>B8MHN6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AAA family ATPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_011260</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483251.1">
        <property type="nucleotide sequence ID" value="XM_002483206.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B8MHN6">
        <property type="interactions" value="740"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MHN6"/>
    <dbReference type="GeneID" id="8109899"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_011260"/>
    <dbReference type="eggNOG" id="KOG0732">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000536_3_1_1"/>
    <dbReference type="InParanoid" id="B8MHN6"/>
    <dbReference type="OMA" id="VTPKDFM"/>
    <dbReference type="OrthoDB" id="5421at2759"/>
    <dbReference type="PhylomeDB" id="B8MHN6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140674">
        <property type="term" value="F:ATP-dependent histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED16448.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
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    <sequence length="1353" mass="147383" checksum="B0EFDD48615A9762" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MI63</accession>
    <name>B8MI63_TALSN</name>
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        <submittedName>
            <fullName evidence="10">Multidrug resistance-associated protein, putative</fullName>
        </submittedName>
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        <name evidence="10" type="ORF">TSTA_022790</name>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    <dbReference type="GeneID" id="8107116"/>
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    </dbReference>
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        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
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        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
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        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)-RELATED"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC transporter transmembrane region"/>
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    </dbReference>
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        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="279" mass="30679" checksum="94746C21EEBDBC02" modified="2009-03-03" version="1">MIRGGLVTLVYDATLKLHSSKATDAAAVTHMSTDIDQITQGMTNFDVLWAAPIEVGLAIYILWREIGLACLAPVGIAVGCTLAAFLLGKLSRKAQRVWVDAVQLRTTATVSMLNNIKGIRMSGLSSRFSTNIQDLRVKELAASKSYRHLTVLKNTIGTLPQVMGPITAFVIYVLVRQNQPVSKCLRLLARISSKMSTHEISEHRDIEPCHLDAPPRMPLLSDNPAFKTRQKDRLFNLTGLKGTFRHISGHLDFSPIFTPPDSSQITPPKVSIKDPALKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MII6</accession>
    <name>B8MII6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_045400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002484986.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MII6"/>
    <dbReference type="GeneID" id="8099504"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_045400"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_30_0_1"/>
    <dbReference type="InParanoid" id="B8MII6"/>
    <dbReference type="OMA" id="NIHIYSD"/>
    <dbReference type="OrthoDB" id="4226915at2759"/>
    <dbReference type="PhylomeDB" id="B8MII6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="8">
        <location>
            <begin position="46"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED15078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="361" mass="39788" checksum="61D7ADEF06B00303" modified="2009-03-03" version="1">MWPICQGPLGTLPRLILPEIPYSSKPVGTPNHXXVTVLPHKGLTTRAGVTLQAVPGGPWEHVEVPMGHGHEVFDAELVGVATALEWALERQPLGPIWVFLDAQNAIDRLRSTRPGPGQALVLRAHKAAEKLALRGQPVTIQWVPGHSGIEGNEQADQAAKRAASKQTAPGFEHLSLAHVRRACTEARRAAVSEWAQINAVQGRHRDGRVYKMPRGWNLDPVAGKAPKRLASRYYQLKTGHAPIGTYLYRIGRRESPECQACKEPHETVRHVLFECRGRRTGRRTLYQALKKAGVPLPTAAEEDPEARLFAEPRATQGLLQFVAEANLFNDKERTAREAESSDAWGWDTLEEGGLGVTLEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIU9</accession>
    <name>B8MIU9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glucose transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_050500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485564.1">
        <property type="nucleotide sequence ID" value="XM_002485519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIU9"/>
    <dbReference type="STRING" id="441959.B8MIU9"/>
    <dbReference type="GeneID" id="8109092"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_050500"/>
    <dbReference type="eggNOG" id="KOG0253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_52_2_1"/>
    <dbReference type="InParanoid" id="B8MIU9"/>
    <dbReference type="OMA" id="GTPKYRC"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="PhylomeDB" id="B8MIU9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="523"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="86"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED15611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="549" mass="60278" checksum="38CFF77964B381A1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJF1</accession>
    <name>B8MJF1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_046060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485104.1">
        <property type="nucleotide sequence ID" value="XM_002485059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJF1"/>
    <dbReference type="GeneID" id="8106508"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_046060"/>
    <dbReference type="eggNOG" id="ENOG502SP0W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139288_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJF1"/>
    <dbReference type="OMA" id="QIHQIAR"/>
    <dbReference type="OrthoDB" id="2772415at2759"/>
    <dbReference type="PhylomeDB" id="B8MJF1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED15151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="121" mass="13795" checksum="43F17B419958F3B2" modified="2009-03-03" version="1">MAETPQKGFYRIVTVNTAPERAKRLIGRMVEALKDRYTIIHVDNCETIEEVEPKVKEHQPDVLFCASMWTAEQSTAVFEIARKIRPGIKTHAIPHGLQVERGPDAIVEYLVENVPKLLDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJH6</accession>
    <name>B8MJH6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="9">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_046300</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="9"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485129.1">
        <property type="nucleotide sequence ID" value="XM_002485084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJH6"/>
    <dbReference type="FunCoup" id="B8MJH6">
        <property type="interactions" value="235"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MJH6"/>
    <dbReference type="GeneID" id="8099541"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_046300"/>
    <dbReference type="eggNOG" id="KOG2108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004585_4_2_1"/>
    <dbReference type="InParanoid" id="B8MJH6"/>
    <dbReference type="OMA" id="VCTFHAF"/>
    <dbReference type="OrthoDB" id="1470711at2759"/>
    <dbReference type="PhylomeDB" id="B8MJH6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17932">
        <property type="entry name" value="DEXQc_UvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18807">
        <property type="entry name" value="SF1_C_UvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.486.10:FF:000011">
        <property type="entry name" value="ATP-depentend DNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.486.10">
        <property type="entry name" value="PCRA, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF2">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE SRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="13">
        <location>
            <begin position="8"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="14">
        <location>
            <begin position="286"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="733"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="889"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="917"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="935"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="29"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED15176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1033" mass="114521" checksum="FC07E9A852218670" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJY4</accession>
    <name>B8MJY4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_042750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484754.1">
        <property type="nucleotide sequence ID" value="XM_002484709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJY4"/>
    <dbReference type="GeneID" id="8104752"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_042750"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_6_1"/>
    <dbReference type="InParanoid" id="B8MJY4"/>
    <dbReference type="OMA" id="APPYLFM"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="PhylomeDB" id="B8MJY4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF78">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="49"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED14801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="510" mass="57269" checksum="B3747F7D9B5B5152" modified="2009-03-03" version="1">MAADGIIRDHEAMGEKAELAHEEIVHLTELTPQEKILEKKLLRRIDSIILPFVIIVYLMNYIDRNNYASAKLQGLMASLHMNDSQYQTGLSILFVGYILMQVPSNLALNYIGRPSVYIGFFVAAWGLVSALTSQVKSYGAIIACRFILGIVEAPFFAGILFYLSSWYTKKELALRMSIFYSGSLLSGAFGNLIAAGILSGLEDARGMAAWQWLYIIEGSITIFVGILIMLFLPDFPENWRLLSPEMKAVAMRRLAIDAAEADSDESGGMSQWRGAKLAFTDKRTYLFALAYMCVVAATGFQYFFPTLTKTLGYSNIISLLLVAPPYVFMVFYSILHNHISDKFQKRFIFYVIPIPISIVGFIIFMTTSSFGPRYLSLFLMNFAFCMIATIFGWIGSTIARPPAKRAAAYAFINSIGNSASIWTAYTYRAQDAPHYRPALGICIAMLGVAFLTGLYLYVDLRSENKRLERLENEDSILSERDLRRLQKTAEVEGIDVAAARRLQKGFRYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8MK99</accession>
    <name>B8MK99_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_047050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485207.1">
        <property type="nucleotide sequence ID" value="XM_002485162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MK99"/>
    <dbReference type="STRING" id="441959.B8MK99"/>
    <dbReference type="GeneID" id="8098498"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_047050"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="InParanoid" id="B8MK99"/>
    <dbReference type="OMA" id="MSSPVWF"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="PhylomeDB" id="B8MK99"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED15254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="277" mass="29775" checksum="AF5D31C51303AA35" modified="2009-03-03" version="1">MATESPVWCITGASSGFGREIALQAVQRGHRVIATARDVSKISDIRQKGALTLALDVSDAFDKLAEIAKSAIQEYQRVDYLINAAGYILEGAVEEAGSEEVQRQFAVSRELLQNGDHRATIAVFGSLGSWIGGASYAFYAMTKASMSSLAESLKEELAPFDIRATVIEPGYFRTGFLNPGAKASTAERIPAYEDESTPSGQVRKGLEAHDGKQLGDVKKGVSVCVDILTSSGIAEGRELPLRVIIGSDCVDVIRKKCQSTLELLDSWEEVSVTTDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLK0</accession>
    <name>B8MLK0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RING finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_049710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485486.1">
        <property type="nucleotide sequence ID" value="XM_002485441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLK0"/>
    <dbReference type="STRING" id="441959.B8MLK0"/>
    <dbReference type="GeneID" id="8108735"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_049710"/>
    <dbReference type="eggNOG" id="ENOG502S6DH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047453_0_0_1"/>
    <dbReference type="InParanoid" id="B8MLK0"/>
    <dbReference type="OMA" id="CLQSWRH"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="PhylomeDB" id="B8MLK0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347">
        <property type="entry name" value="RING/FYVE/PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347:SF1">
        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="6">
        <location>
            <begin position="54"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED15533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="328" mass="36902" checksum="DF716DC530283CB8" modified="2009-03-03" version="1">MFSSSRKAPPTWTWPEDLPDSTPGAFPEPSQKEPDATTSAESTQSTSTPNQNPEHRYPPRMCRICLDTVNPTSETESQYLPSMLQSKPRVVYVSPDPELGRLIRPCKCKGSSRYVHEGCLQSWRHADPSYGRRNYFQCPTCGFKYRIQRVIWARWITSSVAQLALTFSILLLTVFILGFIADPIINLYLPPVDTIIDSDFWEETHVLDVPDLGEATTWFEHFLKGLASLGVLSIIKVFLAMSPWGWLHLRSSALFGAGGRTTGRTRVASISWVVILFGVVTFLVAVFKGVRQLVHRTLRRAGESVLDIQGEDDDKDLDEGSDHVKKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLL4</accession>
    <name>B8MLL4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Polyketide synthase, putative</fullName>
            <ecNumber evidence="13">2.3.1.161</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_049850</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.161" evidence="13"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485500.1">
        <property type="nucleotide sequence ID" value="XM_002485455.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MLL4"/>
    <dbReference type="GeneID" id="8108749"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_049850"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_31_0_1"/>
    <dbReference type="InParanoid" id="B8MLL4"/>
    <dbReference type="OMA" id="MACASIV"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="PhylomeDB" id="B8MLL4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050637">
        <property type="term" value="F:lovastatin nonaketide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000002">
        <property type="entry name" value="Probable polyketide synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="20"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="958"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2345"/>
            <end position="2426"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="9">
        <location>
            <begin position="958"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="9">
        <location>
            <begin position="1126"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="9">
        <location>
            <position position="990"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="9">
        <location>
            <position position="1190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED15547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="2434" mass="267301" checksum="B8A7FCA8DE0A49F6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLZ5</accession>
    <name>B8MLZ5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_097630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485745.1">
        <property type="nucleotide sequence ID" value="XM_002485700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLZ5"/>
    <dbReference type="GeneID" id="8108402"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_097630"/>
    <dbReference type="HOGENOM" id="CLU_2074712_0_0_1"/>
    <dbReference type="InParanoid" id="B8MLZ5"/>
    <dbReference type="OrthoDB" id="2976890at2759"/>
    <dbReference type="PhylomeDB" id="B8MLZ5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED13507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="118" mass="13112" checksum="7D3A17F087D17B93" modified="2009-03-03" version="1">MSTLSNEPVPAPHQNISSNELSLALRLHGVLKEAVTEMIDFFCNTITPPAGPLDIFIEPAKSGLDPMQALLRWVIETQQPFTVVEHPTWKELLKSLNANCPIKTADTLQNRVQSEYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMT0</accession>
    <name>B8MMT0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">60S ribosomal protein L37</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_100780</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486074.1">
        <property type="nucleotide sequence ID" value="XM_002486029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMT0"/>
    <dbReference type="FunCoup" id="B8MMT0">
        <property type="interactions" value="566"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MMT0"/>
    <dbReference type="GeneID" id="8097962"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_100780"/>
    <dbReference type="eggNOG" id="KOG3475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1714534_0_0_1"/>
    <dbReference type="InParanoid" id="B8MMT0"/>
    <dbReference type="OrthoDB" id="10259236at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_eL37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED13836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="153" mass="17214" checksum="B16CECF7098A3724" modified="2009-03-03" version="1">MSTSRTLLRSTLTTIRRVPPALVSVTTRRTRSADDAIFEGNCGVNFKSGSEGISMEMNTKGRREWPGYPRRRDGEGLFTNCQGRKRSFHIQKSTCANCGYPAAKTRKYNWSEKAKRRKTTGTGRMRYLKTVDRKFHNGFQTGTPKGARGPTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8MND3</accession>
    <name>B8MND3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_102520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486260.1">
        <property type="nucleotide sequence ID" value="XM_002486215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MND3"/>
    <dbReference type="STRING" id="441959.B8MND3"/>
    <dbReference type="GeneID" id="8100829"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_102520"/>
    <dbReference type="eggNOG" id="ENOG502SN8C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055163_0_0_1"/>
    <dbReference type="InParanoid" id="B8MND3"/>
    <dbReference type="OMA" id="IYRETWF"/>
    <dbReference type="OrthoDB" id="288942at2759"/>
    <dbReference type="PhylomeDB" id="B8MND3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="45148" checksum="6DED7F6D3A8F6B63" modified="2009-03-03" version="1">MTAPSLSLRSNINLQYQSPLFSVLPAEIRSLIFKYALTDYEDITTHMSYDRDTYWYRPGYMAKRRTATELLRTCKRIFQETWFLPFALAEHCFYLTNTARAPSEHVTVARMKEYLTTLRDFARNQDGMEIPQIERIRVFAQMFVLEDSPRLQEVLDMEGFQPKHITITLRYTDFWFWEHNSPIHIDAKWVNTVRFPKSVATISMDFEMVDRRKEEIDYITNLAVDKWFFRRADGIVFKANKEDIKTSRWTGSSTLGDARWIRDESRTNEIDYYVKTVTWKPVPEFDPFTGGGDGCPNLDIPHDFPRQTPPFGRMPNVPVDDLQYLDCSDNLSAQQVYDSILGMDEEMWEEAMSEEEMSEEGMSEEEMSEEGMSEEEMSEEEMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNQ7</accession>
    <name>B8MNQ7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-L-isoaspartate O-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.77</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_103670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12143"/>
            <dbReference type="Rhea" id="RHEA-COMP:12144"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90596"/>
            <dbReference type="ChEBI" id="CHEBI:90598"/>
            <dbReference type="EC" id="2.1.1.77"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="7"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486384.1">
        <property type="nucleotide sequence ID" value="XM_002486339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNQ7"/>
    <dbReference type="STRING" id="441959.B8MNQ7"/>
    <dbReference type="GeneID" id="8103070"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_103670"/>
    <dbReference type="eggNOG" id="KOG1661">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055432_0_0_1"/>
    <dbReference type="InParanoid" id="B8MNQ7"/>
    <dbReference type="OMA" id="HMHASAC"/>
    <dbReference type="OrthoDB" id="73890at2759"/>
    <dbReference type="PhylomeDB" id="B8MNQ7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000259">
        <property type="entry name" value="Protein-L-isoaspartate O-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00080">
        <property type="entry name" value="pimt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579:SF0">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01135">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01279">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED14146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="242" mass="26010" checksum="EB6B2A9C8B885FE5" modified="2009-03-03" version="1">MAWFCSGTNNTELIENLWSAGLIKNKRVKKAMLGVDRDHYAPSSPYSDSPQPIGYGATISAPHMHGHACEYLIDFLHPGSRVLDIGSGSGYLTHVIANLITDPSSPPTDADGHVIGIEHIQELVDLARENMGKSEDGRNFLKSGKVQFVCGDGRRGWPEGGPYDAIHVGAAAVELHAPLIEQLKAPGRMFIPVESEEGEDGLSHVGLGGGQYIWVVDKKADGTVVKEKVFGVSYVPLTDAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPG6</accession>
    <name>B8MPG6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_106140</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486643.1">
        <property type="nucleotide sequence ID" value="XM_002486598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPG6"/>
    <dbReference type="FunCoup" id="B8MPG6">
        <property type="interactions" value="607"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MPG6"/>
    <dbReference type="GeneID" id="8098767"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_106140"/>
    <dbReference type="eggNOG" id="KOG1651">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029507_3_2_1"/>
    <dbReference type="InParanoid" id="B8MPG6"/>
    <dbReference type="OMA" id="TFPMTEK"/>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="PhylomeDB" id="B8MPG6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061692">
        <property type="term" value="P:cellular detoxification of hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000010">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="168"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED14405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="198" mass="21400" checksum="DC2A461FC323E72F" modified="2009-03-03" version="1">MASATTFYDFSPPDKKGNPYPLTNFKGKVVLVVNTASKCGFTPQFAGLEKLYKSIEAKHPGAFTILGFPCNQFGNQDPGSNDDIQSFCQVNYGVTFPVLGKIDVNGSKAEPVFEWIKAQKPGLFGVKRVLWNFEKALINSKGEVVGRWRSITKPESLEATIVKEIENAQKSGDIPAPAPTATETAAAPAQAETEAKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQF5</accession>
    <name>B8MQF5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_058450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487468.1">
        <property type="nucleotide sequence ID" value="XM_002487423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQF5"/>
    <dbReference type="GeneID" id="8106447"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_058450"/>
    <dbReference type="HOGENOM" id="CLU_2575470_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQF5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED13357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="81" mass="8796" checksum="9E522EE54981699E" modified="2009-03-03" version="1">MTEGLKLIMEFSCAEILRAGLYGRIYPGFATVSPNGSTDDVSENSLGPPAIESTVNVMEGLPARECTSDEQVAKYVPWDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQG3</accession>
    <name>B8MQG3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Arabinan-endo 1,5-alpha-L-arabinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_058540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487476.1">
        <property type="nucleotide sequence ID" value="XM_002487431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQG3"/>
    <dbReference type="STRING" id="441959.B8MQG3"/>
    <dbReference type="GeneID" id="8106456"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_058540"/>
    <dbReference type="eggNOG" id="ENOG502SM8A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016508_2_1_1"/>
    <dbReference type="InParanoid" id="B8MQG3"/>
    <dbReference type="OMA" id="KLTEAPH"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="PhylomeDB" id="B8MQG3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09000">
        <property type="entry name" value="GH43_SXA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF12">
        <property type="entry name" value="BETA-XYLOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="8">
        <location>
            <begin position="315"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="6">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED13365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="528" mass="60314" checksum="05F374334121AF7E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQI4</accession>
    <name>B8MQI4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_058740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487497.1">
        <property type="nucleotide sequence ID" value="XM_002487452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQI4"/>
    <dbReference type="STRING" id="441959.B8MQI4"/>
    <dbReference type="GeneID" id="8106476"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_058740"/>
    <dbReference type="eggNOG" id="ENOG502T2AW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041579_1_0_1"/>
    <dbReference type="InParanoid" id="B8MQI4"/>
    <dbReference type="OMA" id="LKMILRH"/>
    <dbReference type="OrthoDB" id="5337545at2759"/>
    <dbReference type="PhylomeDB" id="B8MQI4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="429" mass="47052" checksum="FD5ECB177F08ACE6" modified="2009-03-03" version="1">MSSNPDKTNPPARSDPTKDDHPPSSSETTTKNPSEPSILNRVKNSATSLIQDALTKPSAGTLPSDLAHALNSGNNNKGYASASASASSSTYLENARRRDGASSSPSDGIYDHDAEAFRSGSTHPSTSSGVVLDPLEINSFQNTGRFHSLPDEFSETKGKGKAKQTFENHDYADINEFEYDSTHFNEYEIAWINASRQGSYHSSSTTTNSTPTKRLSSSGSTSSVHNSSVINGVERNEKDGAEVVSLLSDPSFQPGLSTWDDQDSQNMDGYDFTFGADDPLDMDGFPIDPGLSPAELKILESFRLQHQTQNQEENKTKRITPYSLIPDIDSFLSQHMDTNHGISSDENLRDEVLTNLVGAEEWVHVDEQYSDDVWGYLRPALEAAAAEIKEKEAAGKEDEDGPAVKRLKMILRHMARIMILKQETEMIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MR35</accession>
    <name>B8MR35_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF7728 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_054420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487041.1">
        <property type="nucleotide sequence ID" value="XM_002486996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MR35"/>
    <dbReference type="GeneID" id="8100380"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_054420"/>
    <dbReference type="eggNOG" id="ENOG502SC3G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051864_0_0_1"/>
    <dbReference type="InParanoid" id="B8MR35"/>
    <dbReference type="OMA" id="CRGKPKC"/>
    <dbReference type="OrthoDB" id="5409353at2759"/>
    <dbReference type="PhylomeDB" id="B8MR35"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056145">
        <property type="entry name" value="DUF7728"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40622">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40622:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24854">
        <property type="entry name" value="DUF7728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877660" description="DUF7728 domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7728" evidence="4">
        <location>
            <begin position="43"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED12930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="365" mass="40349" checksum="76258F33949B5769" modified="2009-03-03" version="1">MLFRSLVAASALSLSASAFLVVPEVQQPNDLPVTHALELEDAQSEKFQLLCDDCPFPETVSDGIVRWTENTKSSLELNFHAENGNLYVNDAHIFPVTFNSVETVKAVQRRESDGKETEPLTLGFALMALPLAPPQDDLELLQIRFSPLDIDGHPAPLDTVSITAIRTTAGELFILRAEVELPAGEDDHASWKECNGDTECLRHLIFDRIRALVQAAQAHMMNLKSKLGFGKGCHGKSLPGHRKAGHHGPGFGEVEEGHQPPHPHHRHRHMHGLRRTLFAIIRFVIVPAVLGIFAGLTASAIGMLVGQAVVFLWMRYRRGSKNIRSTSSLEQGTESEKAILIMEEEVSNEEDLPPYNDEHHALDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B8MR55</accession>
    <name>B8MR55_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclin Ccl1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_054600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487061.1">
        <property type="nucleotide sequence ID" value="XM_002487016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MR55"/>
    <dbReference type="FunCoup" id="B8MR55">
        <property type="interactions" value="930"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MR55"/>
    <dbReference type="GeneID" id="8100398"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_054600"/>
    <dbReference type="eggNOG" id="KOG2496">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022620_4_1_1"/>
    <dbReference type="InParanoid" id="B8MR55"/>
    <dbReference type="OMA" id="KSIMACA"/>
    <dbReference type="OrthoDB" id="340962at2759"/>
    <dbReference type="PhylomeDB" id="B8MR55"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20524">
        <property type="entry name" value="CYCLIN_CCNH_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000095">
        <property type="entry name" value="Cyclin Ccl1, putative (AFU_orthologue AFUA_5G07030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
        <property type="entry name" value="Cyclin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin C-terminal" evidence="3">
        <location>
            <begin position="191"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED12950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="422" mass="46929" checksum="A828CD91BEA055F9" modified="2009-03-03" version="1">MIEDEIYKTSTQFRIWSFTKESLKSLRANTNAVACEHLRAAQNRAREVPRSATPSTSGNLTPNPSDNEAKAEAALGKDVECLTAEEELMFVSYYCEQALELGDNYKPPLPTMVRATAIQYLRRFYLTNSVMTYHPKTIMPCALFLATKTDNYYLSLNEFAKSVPKIDRPADVIAPEYTLTQALRYTFDVRHPFRGLEGGIMELQAIAQGEGRPGPLNTGQTPEIMKQAINSIEPIPGSDKGSISSRISLAHDNARDILKKAAQMTDAYFFYTPSQIWLSALFIVDKPLAQFYLDAKVGPDVRSGVVDSGNPLEMIRMKLLTTLSDCVSLLESYTPFSANSENLKELKAIAKKVYQCQMIEKLDPAAPGSGQKRSTGISGAEGASESELERVAKKRRLERERREKEGKDIFGGELVARRKKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRB3</accession>
    <name>B8MRB3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_055140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487119.1">
        <property type="nucleotide sequence ID" value="XM_002487074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRB3"/>
    <dbReference type="GeneID" id="8102207"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_055140"/>
    <dbReference type="eggNOG" id="ENOG502SNH2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023880_4_0_1"/>
    <dbReference type="InParanoid" id="B8MRB3"/>
    <dbReference type="OMA" id="REATWNY"/>
    <dbReference type="OrthoDB" id="3862662at2759"/>
    <dbReference type="PhylomeDB" id="B8MRB3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED13008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="512" mass="56964" checksum="25651E0B97F61FA5" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRD8</accession>
    <name>B8MRD8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDHD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_055380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487144.1">
        <property type="nucleotide sequence ID" value="XM_002487099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRD8"/>
    <dbReference type="STRING" id="441959.B8MRD8"/>
    <dbReference type="GeneID" id="8102231"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_055380"/>
    <dbReference type="eggNOG" id="KOG2308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002680_0_1_1"/>
    <dbReference type="InParanoid" id="B8MRD8"/>
    <dbReference type="OMA" id="HSSYWIL"/>
    <dbReference type="OrthoDB" id="69269at2759"/>
    <dbReference type="PhylomeDB" id="B8MRD8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF6">
        <property type="entry name" value="PHOSPHOLIPASE C1020.13C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="2">
        <location>
            <begin position="663"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED13033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="887" mass="98252" checksum="56B4E39A032F1327" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSC2</accession>
    <name>B8MSC2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_000500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED11973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487627.1">
        <property type="nucleotide sequence ID" value="XM_002487582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSC2"/>
    <dbReference type="GeneID" id="8108673"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_000500"/>
    <dbReference type="HOGENOM" id="CLU_051551_2_1_1"/>
    <dbReference type="InParanoid" id="B8MSC2"/>
    <dbReference type="OrthoDB" id="4526357at2759"/>
    <dbReference type="PhylomeDB" id="B8MSC2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="106" mass="11146" checksum="B637B968CD97EF0A" modified="2009-03-03" version="1">MTHKGPGIDSPLQTALLESTSAATTRASEGQKIFSPIAVFLDKHRSQTTGLASHLLRALTALSDDLASVAQQHFNAYISALKEVQAIKTGFALCPSSPEALLALEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTN5</accession>
    <name>B8MTN5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Actin Act1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_004830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488094.1">
        <property type="nucleotide sequence ID" value="XM_002488049.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488095.1">
        <property type="nucleotide sequence ID" value="XM_002488050.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488096.1">
        <property type="nucleotide sequence ID" value="XM_002488051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTN5"/>
    <dbReference type="FunCoup" id="B8MTN5">
        <property type="interactions" value="1294"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MTN5"/>
    <dbReference type="GeneID" id="8104467"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_004830"/>
    <dbReference type="eggNOG" id="KOG0676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027965_0_2_1"/>
    <dbReference type="InParanoid" id="B8MTN5"/>
    <dbReference type="OMA" id="FHTTAER"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000404">
        <property type="entry name" value="Major actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED12440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="375" mass="41623" checksum="1FCDDC02E6E72414" modified="2009-03-03" version="1">MEEEVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHHGIMIGMGQKDSYVGDEAQSKRGILTLRYPIEHGVVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPINPKSNREKMTQIVFETFNAPAFYVSIQAVLSLYASGRTTGIVLDSGDGVTHVVPIYEGFALPHAISRVDMAGRDLTDYLMKILAERGYSFSTTAEREIVRDIKEKLCYVALDFEQEIQTASQSSSLEKSYELPDGQVITIGNERFRAPEALFQPSVIGLESGGIHVTTYNSIIKCDVDVRKDLYGNIVMSGGTTMYPGISDRMQKEITALAPSSMKIKIIAPPERKYSVWIGGSILASLSTFQQMWVSKQEYDESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8MU50</accession>
    <name>B8MU50_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_109470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488524.1">
        <property type="nucleotide sequence ID" value="XM_002488479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MU50"/>
    <dbReference type="STRING" id="441959.B8MU50"/>
    <dbReference type="GeneID" id="8107179"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109470"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_48_0_1"/>
    <dbReference type="InParanoid" id="B8MU50"/>
    <dbReference type="OMA" id="LPHTCAP"/>
    <dbReference type="OrthoDB" id="4223509at2759"/>
    <dbReference type="PhylomeDB" id="B8MU50"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF65">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_20, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="83"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED11768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="421" mass="47083" checksum="B671450496A48554" modified="2009-03-03" version="1">MRMTDLPTELSILIATFLQKERDINNLTQVNKKLYYDLNWYLYKHNYLHGNSSALRWAAKYGEKSTAVMSMRERASITSIDKYNMTPLSWAAAGGHIAIVELLLKSAGVICADDEAANGNSIIEKPPPIGDSFTSLNMEYYHDTKQLWKKLACKLSTATRRVPEFNLNCRDHLNQTPLSLAAAGGHYAVVAVLLNIAEVEIDSRDDNDRTPLWRAASVGSVQVAKLLLETGKVDPDCRDSYNETPLQQAVIYGHEEVVRLLLKTGVVDLHGRDRFGRTLLHLAIIQRHEAVANILIETKNFDLNSKDHWGQTPLRLAAAHRCGATVRLLLDTDSVDINCADYQGRTPLSLAAGNGYETITRLLIEKDETELNSKDRLDQTSLWWAATQGHASIVKLLLETPGVDSEYIWDLDTLKANSLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUR7</accession>
    <name>B8MUR7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_109850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488561.1">
        <property type="nucleotide sequence ID" value="XM_002488516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUR7"/>
    <dbReference type="STRING" id="441959.B8MUR7"/>
    <dbReference type="GeneID" id="8107217"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109850"/>
    <dbReference type="HOGENOM" id="CLU_628778_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUR7"/>
    <dbReference type="PhylomeDB" id="B8MUR7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="48056" checksum="B7C75B71EAFF9BE9" modified="2009-03-03" version="1">MQQLSRPLHRQNFEIALIYALPVEREAVEALLDVKYETHSLSSGKSPGDLTAYITGRISGYHIVLAYLPHPGKAIAAGAASYLRSHFEGIKICIVIGVWGDNLGNRNLEITSFLRNLSCQPALQRLQHKTLSYSKELLEQLRSPEFAWPGADEDKFSPSNYRHKHQDPNVCTTCARCYHLEDSVCDAASKLSCIALGCDDMLLERRGWRNRQGELEASDGLLSRNSLMSGVAEIVGAAGIGRALLSISGRILGVLIAFEMEGAGVWQYLPTIIVKGGYSAITAAASTKVIIEEWSMQRPLKALIPFSLSDGAYHIDPGAGRYYVLWNKKYYTTQTEGGNTSGAEDTKKKFEELEAALKTVPTQAAIEPEIALPESALAQQDFCRVVRTQLRLYSASREGFQRTALALAAVIKTNKSDPELSWLTLRLGASELHRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8MV55</accession>
    <name>B8MV55_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_008090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962662">
        <property type="protein sequence ID" value="EED11511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488692.1">
        <property type="nucleotide sequence ID" value="XM_002488647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MV55"/>
    <dbReference type="STRING" id="441959.B8MV55"/>
    <dbReference type="GeneID" id="8110146"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_008090"/>
    <dbReference type="eggNOG" id="KOG0351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001104_4_1_1"/>
    <dbReference type="InParanoid" id="B8MV55"/>
    <dbReference type="OMA" id="GREIMEQ"/>
    <dbReference type="OrthoDB" id="4507197at2759"/>
    <dbReference type="PhylomeDB" id="B8MV55"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="501" mass="58405" checksum="4B0494210611F193" modified="2009-03-03" version="1">MAPRRVRPRGEEAMSDRSRDRLEGDADPEEVDPGEDDDEEYDEENEEEEERIVRREYDSALICATAILGAREDGWRTPNDYPPILSKLIKLARFMVVRKAIELSAVLKGNELQSSMNDADWDSTDRGSLSHFHSHTNQKGCLQWVTQMVDTFMIRGSQSPMQWMLDLRTYGLKIHYNTTTEGHVGWQNHDELLYKDLQFTMSEFRGMVDRTTREARRILILLQCSPEEAPAIPWDRLYDNPVNEDFCWSFLQDSHTTWPIDGTSWLWQHIQRHPALHCKFIHVDEQSIQQAGGIRNVFIEDGLVVLVTKYHKGYQMSGNVKIIQRYVPREVRELLSSERLRWILKWESAIGLGGRTLTTALYREVAIAISHRFMRNSRAFTRSAADEAKADEEEDEIMDHVADEQATHSPNTAGNIYAREWMERVGEVAERRLRFQQSSQEWHQFLEFPSTMRKLREDQTTPFQDSAENRRVEQWKATRAADPIQVLQEMMGEPITFQGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>B8MVB0</accession>
    <name>B8MVB0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_008620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962662">
        <property type="protein sequence ID" value="EED11566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488747.1">
        <property type="nucleotide sequence ID" value="XM_002488702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MVB0"/>
    <dbReference type="GeneID" id="8103250"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_008620"/>
    <dbReference type="HOGENOM" id="CLU_1788115_0_0_1"/>
    <dbReference type="InParanoid" id="B8MVB0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="145" mass="16864" checksum="21A698F27BDBCF3E" modified="2009-03-03" version="1">MLSKIAAVKNIEKRVSTELVGENYRSLSATIILAKFEHKLRQEKNLAELRIKTKLLEVIELRSTLLEHYDEILDSAQKSNEEKRISTFEKSIITHKWFLDRLKGIVESLSIPGLADETNEFDAFCMILQDWINIMIDEWKDVLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MVG1</accession>
    <name>B8MVG1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_007590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962663">
        <property type="protein sequence ID" value="EED11469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488785.1">
        <property type="nucleotide sequence ID" value="XM_002488740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MVG1"/>
    <dbReference type="STRING" id="441959.B8MVG1"/>
    <dbReference type="GeneID" id="8103288"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_007590"/>
    <dbReference type="HOGENOM" id="CLU_900666_0_0_1"/>
    <dbReference type="InParanoid" id="B8MVG1"/>
    <dbReference type="OMA" id="PQVVITC"/>
    <dbReference type="OrthoDB" id="4357294at2759"/>
    <dbReference type="PhylomeDB" id="B8MVG1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="305" mass="33791" checksum="6ABD47659AED98F6" modified="2009-03-03" version="1">MTASLLTLDVKGAFDAVLPGRLIRRLREQGWPTNLVLWIASFATGRSVQIRLDGEIGASTNITCGLPQGSPVSGILFMLYIAPLFRLGNPRNKFALLATIRLRRLDPYHPLRRRAEQVASNGRQTSRFARRILALPNSEQINPLQYAPWHPRESHENAQARIGAPMGRTKEQAAADFTAFQRTIPSSDIIIFSDGSRLVDRRAGDVYIGFQAHYQFLHSSLLYGHGKEVFDAEAEAALAGAQAVIAYPTAQFATNLWICLDNLEVATRLLSPSTGSSQEVFESFRTLAAAWPLRERLPHTKNGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8LSS2</accession>
    <name>B8LSS2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="3">3.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3-hydroxyisobutyryl-coenzyme A hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_063930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340305.1">
        <property type="nucleotide sequence ID" value="XM_002340264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LSS2"/>
    <dbReference type="FunCoup" id="B8LSS2">
        <property type="interactions" value="690"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LSS2"/>
    <dbReference type="GeneID" id="8108617"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_063930"/>
    <dbReference type="eggNOG" id="KOG1684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_22_0_1"/>
    <dbReference type="InParanoid" id="B8LSS2"/>
    <dbReference type="OMA" id="EVFTMEY"/>
    <dbReference type="OrthoDB" id="1737613at2759"/>
    <dbReference type="PhylomeDB" id="B8LSS2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000026">
        <property type="entry name" value="3-hydroxyisobutyryl-CoA hydrolase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="8">
        <location>
            <begin position="66"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED22918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="495" mass="55507" checksum="9A42C5516F0DF5DF" modified="2009-03-03" version="1">MLLRPTFHRASTPLSRLSRSSFAAMPLRAKVTNPAFASKMSLSTKSSENPAVDSDDVLFYSTYGLRLIELNRPKKLNSLNGSMCQQIIPRLLEWEKSQLANIIMVSGRGEKALCAGGDVAALAINNKEGPEGVKRSQDYFALEYQLDHLIATYSKPFVAVMDGITMGGGVGLSVHAPFRIATERTLFAMPETTIGFFPDVGGSFFLSRLDGEVGTYLALTSERLNGVQAFYTGIATHYVDSSVLSNLTNRLAELVFKDYANLNERNDLVNKTIAEFSTGLPSVEKEPILLRYKLRQAIDRCFKYNTVEEIIQALEKEEDQKEWARKTLETLTSRSPTSLKVTLRQLRLGKNWSIKETFQREHAIASVFMNHPDFVEGVSARLISKPPRTPEWNPSRLEDVTPADVDAFFKIDGEPLPTFHDNDYKTYPHAKYALPTEADIEAFVRGNKTTGSDTVKEFVQNWGQKEGVRAKVTEVLGRRTKKTDKGLEWIETDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8LSV5</accession>
    <name>B8LSV5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SH3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_064200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340338.1">
        <property type="nucleotide sequence ID" value="XM_002340297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LSV5"/>
    <dbReference type="STRING" id="441959.B8LSV5"/>
    <dbReference type="GeneID" id="8104238"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_064200"/>
    <dbReference type="eggNOG" id="ENOG502QTHB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022614_0_0_1"/>
    <dbReference type="InParanoid" id="B8LSV5"/>
    <dbReference type="OMA" id="CADTCAL"/>
    <dbReference type="OrthoDB" id="2163411at2759"/>
    <dbReference type="PhylomeDB" id="B8LSV5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF6">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="341"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="474"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="374"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="485"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED22951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="533" mass="57006" checksum="85EA3F029A10E67F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8LU76</accession>
    <name>B8LU76_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_060410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002339935.1">
        <property type="nucleotide sequence ID" value="XM_002339894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LU76"/>
    <dbReference type="STRING" id="441959.B8LU76"/>
    <dbReference type="GeneID" id="8102688"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_060410"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033740_0_0_1"/>
    <dbReference type="InParanoid" id="B8LU76"/>
    <dbReference type="OMA" id="DHAIHTL"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="PhylomeDB" id="B8LU76"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="140"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="310"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED22548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="406" mass="45467" checksum="A828D5302C8A6371" modified="2009-03-03" version="1">MYAKREFAISMAFKSTCHGSAFSETSVYHPSGPTIVMLKCECGELFKARADPRQHGRAKHHYKCQHCNRSFISSKSLKQHSRDLHNHQCGSCKGMFSSLKSLKRHQKMTGHCYCRSCNLYFTSIDLFRQHATSPDHVGQFHCCDCDRDFVDESALKQHLQNKIHKPPPKHPKGFACDKCERVFSKMASLEQHKKSLAHHPLSDLECIDPKCRKHFRCPSSLLHHLESGTCISGMDRDQLNAIVVAHDTKQIIHTQDHPLEITASEDNGSIFSDTSTNSEIIYTPGTSVSSLTLTNIRIPPANVLSLNEGNRCDVCSRTFKTLRALKDHQQSPVHTSTQFHCPIGLLRGKFESKPVQSFSTLSGLAQHLEAGACAGEIAILREAANYIEGCLEDMGIRKSILLKIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8LU82</accession>
    <name>B8LU82_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_060470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002339941.1">
        <property type="nucleotide sequence ID" value="XM_002339900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LU82"/>
    <dbReference type="STRING" id="441959.B8LU82"/>
    <dbReference type="GeneID" id="8110185"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_060470"/>
    <dbReference type="eggNOG" id="ENOG502SC56">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_30_1_1"/>
    <dbReference type="InParanoid" id="B8LU82"/>
    <dbReference type="OrthoDB" id="4226558at2759"/>
    <dbReference type="PhylomeDB" id="B8LU82"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF25">
        <property type="entry name" value="RNASE H TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="36"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED22554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="356" mass="40882" checksum="1ACF74A67A365780" modified="2009-03-03" version="1">MSRQALEVCLHVPPAELTLAKLAEEACLRIMTSPLRSTLYQIHGQAYCNDPYTLPLHRLETAINRKLGWELEGIDAALEILLRSQPCDDNPHEATIYTDNQAAIRAMCQPGRSSGQYILRRIVRHLGLLRDNRSRWRVRLQWVPGHEGVPGNEKADQLAKLAAVEATRCTQENARIARISAPNQTTPYAARMSYIPNQSTILTAVCRQRLHAGFAKRWKEQWEHTNHGWHLYWIIKAPTKMVLQLHEGLQRAWSSVLIQLQIGKSALRSFLASVRIEDSPQCECGLGDQDTAHVLIRCPTHINLRMETLWKEARETDYRKLLSEPQWVWQSNKFMMRTGLLTQFHHVTPLITTRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8LV92</accession>
    <name>B8LV92_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_065950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340529.1">
        <property type="nucleotide sequence ID" value="XM_002340488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LV92"/>
    <dbReference type="STRING" id="441959.B8LV92"/>
    <dbReference type="GeneID" id="8104206"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_065950"/>
    <dbReference type="HOGENOM" id="CLU_754743_0_0_1"/>
    <dbReference type="InParanoid" id="B8LV92"/>
    <dbReference type="OMA" id="RNTHPSH"/>
    <dbReference type="OrthoDB" id="3787051at2759"/>
    <dbReference type="PhylomeDB" id="B8LV92"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="367" mass="41901" checksum="C9D50E3A6AE9545E" modified="2009-03-03" version="1">MTETGFNTVTGHKKIDPTLWEKDAGPGDSVEALVNYTIRAMYEAAISHYFDRELFKWLHDYFKEWTLVEFNKLDRTTRSKLKDFLQIRGVYLDHRAQLTPRSDTTPPAKRIENHNRDHLIGLPYSDKEKEETTLGRDPERRINNNPLQLETHVRDLDSRTPLTGANAVPIGTPAPSLIKISTTPPPRPSTSLTSARQLDEYMRLPPTEYEQEDIDPSLAAKFSKAWDKAESYSGERYDILDDKVLAFLRVCRLIGVQLTQYAYKAIKAYFDTDSNHQVYYQDWTSTTLKGILRNNPSKTLMEAVEILIEKLHLCQRALGNAYKGQEHLVAAVTRVCQDLPEMSDALSDPATNFETLVSRLRARAAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVK9</accession>
    <name>B8LVK9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_074110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341415.1">
        <property type="nucleotide sequence ID" value="XM_002341374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVK9"/>
    <dbReference type="STRING" id="441959.B8LVK9"/>
    <dbReference type="ESTHER" id="talsn-b8lvk9">
        <property type="family name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="8105118"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_074110"/>
    <dbReference type="eggNOG" id="KOG4178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_16_1_1"/>
    <dbReference type="InParanoid" id="B8LVK9"/>
    <dbReference type="OMA" id="AELSWWY"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="PhylomeDB" id="B8LVK9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877400" evidence="3">
        <location>
            <begin position="29"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="63"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED24028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="364" mass="40187" checksum="511B23F17ADF6CA6" modified="2009-03-03" version="1">MRLKTFSLFLWPFWLVFAPAATTKAVDAGNTSLPWHLTPLKYANTSTLLNVAYYEAGPPNGSAVILVHGFPYSIDAFASVVPLLTGKGYRVIVPYLRGYGETSFLYPDTPRSAEQAALGSDLIALMDAIHIDKAIFAGYDWGTVVVNVAAALWPERCNGHVAANSYLIQNRSTAWVPLDPDSEALRWYYYVFLTARGAAGLASNPKAWARSLWQKNSIGWNFSEEYLDLTATAFENTDYVDIVLNFYRNRLLYAPGDPKYSALALRLDVQPPISARSVTFDPQNSVVFPPTNGTATAKYFTGSRCHYVLPNVGENVPYQAPKMFANAIFAVDNLPLHGTDVISTRNSQREAAASICHHVLPFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVM7</accession>
    <name>B8LVM7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mago nashi domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_075290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mago nashi family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341544.1">
        <property type="nucleotide sequence ID" value="XM_002341503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVM7"/>
    <dbReference type="STRING" id="441959.B8LVM7"/>
    <dbReference type="GeneID" id="8099966"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_075290"/>
    <dbReference type="eggNOG" id="KOG3392">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109497_1_1_1"/>
    <dbReference type="InParanoid" id="B8LVM7"/>
    <dbReference type="OMA" id="IRKEMWI"/>
    <dbReference type="OrthoDB" id="6495301at2759"/>
    <dbReference type="PhylomeDB" id="B8LVM7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11295">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1560.10:FF:000001">
        <property type="entry name" value="Protein mago nashi homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1560.10">
        <property type="entry name" value="Mago nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004023">
        <property type="entry name" value="Mago_nashi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036605">
        <property type="entry name" value="Mago_nashi_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638:SF0">
        <property type="entry name" value="MAGO HOMOLOG, EXON JUNCTION COMPLEX SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638">
        <property type="entry name" value="PROTEIN MAGO NASHI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02792">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89817">
        <property type="entry name" value="Mago nashi protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED24157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="154" mass="17790" checksum="7B27330A08EA4573" modified="2009-03-03" version="1">MSDVNEPFYLRYYSGHSGRFGHEFLEFDFRTLGDGRSASARYANNSNYRNDSLIRKEMCVSSLLIAEIKRIIKDSEIMKEDDSKWPQKNKDGRQELEIRLGSEHISFETAKIGSLVDVTESADPEGLRVFYYLVQDLKALVFSLISLHFKIKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>B8LW57</accession>
    <name>B8LW57_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair protein RAD51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_074630</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required both for recombination and for the repair of DNA damage caused by X-rays.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341472.1">
        <property type="nucleotide sequence ID" value="XM_002341431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LW57"/>
    <dbReference type="FunCoup" id="B8LW57">
        <property type="interactions" value="803"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LW57"/>
    <dbReference type="GeneID" id="8104735"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_074630"/>
    <dbReference type="eggNOG" id="KOG1433">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041732_0_2_1"/>
    <dbReference type="InParanoid" id="B8LW57"/>
    <dbReference type="OMA" id="RAYNSNH"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="PhylomeDB" id="B8LW57"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000262">
        <property type="term" value="C:mitochondrial chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:Swi5-Sfr1 complex binding"/>
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        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:DNA recombinase assembly"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
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        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:heteroduplex formation"/>
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        <property type="term" value="P:mating type switching"/>
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        <property type="term" value="P:meiotic joint molecule formation"/>
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        <property type="term" value="P:meiotic strand invasion"/>
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        <property type="term" value="P:stalled replication fork localization to nuclear periphery"/>
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        <property type="term" value="P:telomere maintenance via recombination"/>
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        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA repair protein RAD51 homolog"/>
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        <property type="entry name" value="DNA repair protein Rad51 homolog"/>
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        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="DNA_recomb/repair_Rad51"/>
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        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
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        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Rad51_C"/>
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        <property type="entry name" value="RecA_ATP-bd"/>
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        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="recomb_RAD51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF39">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="9">
        <location>
            <begin position="100"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="10">
        <location>
            <begin position="280"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU364139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED24085.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="349" mass="37807" checksum="F1A85A4995CFC287" modified="2009-03-03" version="1">MTADVEHQQQEYDDGGLPGPGAPTPLSALEGVAGLTARDIKLIVDGGFHTVESVAYTPKRVLEQIKGISEQKATKILAEASKLVPMGFTTATEMHARRSELISITTGSKQLDTLLAGGIETGSITEIFGEFRTGKSQLCHTLAVTCQLPFDMGGGEGKCLYIDTEGTFRPVRLLAVAQRYGLVGEEVLDNVAYARAYNSDHQLQLLNQASQMMCETRFSLLIVDSATALYRTDFNGRGELSNRQTHLAKFLRTLQRLADEFGIAVVITNQVVSQVDGGPSSMFNPDPKKPIGGNIIAHASTTRLSLKKGRGETRICKIYDSPCLPESDCLFAIREDGIGDPSPKDLENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8LW90</accession>
    <name>B8LW90_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">proline--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_074960</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="4"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341505.1">
        <property type="nucleotide sequence ID" value="XM_002341464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LW90"/>
    <dbReference type="FunCoup" id="B8LW90">
        <property type="interactions" value="392"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LW90"/>
    <dbReference type="GeneID" id="8100221"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_074960"/>
    <dbReference type="eggNOG" id="KOG2324">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016739_2_2_1"/>
    <dbReference type="InParanoid" id="B8LW90"/>
    <dbReference type="OMA" id="NCDYAAN"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="PhylomeDB" id="B8LW90"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00861">
        <property type="entry name" value="ProRS_anticodon_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000066">
        <property type="entry name" value="Proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050062">
        <property type="entry name" value="Pro-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044140">
        <property type="entry name" value="ProRS_anticodon_short"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME PROTEIN L39/PROLYL-TRNA LIGASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753:SF2">
        <property type="entry name" value="PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="89"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED24118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="641" mass="72018" checksum="B3CD9C1625EE7BA0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXC3</accession>
    <name>B8LXC3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_066510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340591.1">
        <property type="nucleotide sequence ID" value="XM_002340550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXC3"/>
    <dbReference type="STRING" id="441959.B8LXC3"/>
    <dbReference type="GeneID" id="8106624"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_066510"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_5_1"/>
    <dbReference type="InParanoid" id="B8LXC3"/>
    <dbReference type="OMA" id="GINPFEW"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="PhylomeDB" id="B8LXC3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="2"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED23204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="271" mass="28808" checksum="80BD9180B257D548" modified="2009-03-03" version="1">MATNEAAYLLEPHQIPLQIRDAPCPSSVEPNTIVVKNHTAYNPFPLKYPFILGQDVAGEVVDVGQGVEGFVKGQRVIGLSEVHTILSANMAAPIPSSVSYEEAVVLPLAVSTAAAGLFQKGFLELPLPTTSPQPLGNTLIVWSGSSSVGLAAIQLARAAGADVVATSSSRTHYLVKSIGASAVFDYTKPTVVDDIVAHLSGKVVLDAYDAISSQQTPRALAEILTKVNSEKHFMAFTGQVEKELPTGVTGKAVFNNIIYDNVLHIFRIKYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXZ5</accession>
    <name>B8LXZ5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transposase Tc1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_062970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340197.1">
        <property type="nucleotide sequence ID" value="XM_002340156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXZ5"/>
    <dbReference type="STRING" id="441959.B8LXZ5"/>
    <dbReference type="GeneID" id="8107648"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_062970"/>
    <dbReference type="eggNOG" id="ENOG502SJME">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038496_0_0_1"/>
    <dbReference type="InParanoid" id="B8LXZ5"/>
    <dbReference type="OMA" id="ANTEWED"/>
    <dbReference type="OrthoDB" id="5415741at2759"/>
    <dbReference type="PhylomeDB" id="B8LXZ5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="1">
        <location>
            <begin position="107"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="443" mass="51307" checksum="23F47F607C3B7F58" modified="2009-03-03" version="1">MVKSSEYSIAQRSQVITLVFLANMKPPDVANLLQMPKKSVYNIINRAKSAGYDPAVKPLVDDCHIVDKPRSGRPKVVTPEIETSILASLTKDRSGREKSAEVLAFEAGISESSCLRLLKFLSFNKCKPTWKPGLTEDMKKRRLAFALSHRHWTLEDWKNIIRTDETSIILGHRRGSSRLFVGRFKNASEFMFWGAFSYDYKGPCHIYDPENAAAKKKALQELEIVNRGREERAREEWELNNAFSRLRLEPRKGRRPTFKFTAKNGKLERKGKGGVDWYRYQKEVLLPKLLPFAARCKESRPHTLVMEDGAPAHAHFHQKDVYDLHEIQRLLWPGNSSDLNAIEPAWFWLKRRTTLQGAPADRETAKKAWLKAWEELPQDRIRTWIERIPFHIEEIIRLDGGNEYEEGRPRGDSKKRCRQKGVLSFRAYLASEPAANTEWEDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZB0</accession>
    <name>B8LZB0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_088990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478626.1">
        <property type="nucleotide sequence ID" value="XM_002478581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZB0"/>
    <dbReference type="STRING" id="441959.B8LZB0"/>
    <dbReference type="GeneID" id="8104866"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_088990"/>
    <dbReference type="eggNOG" id="ENOG502QU1R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_809354_0_0_1"/>
    <dbReference type="InParanoid" id="B8LZB0"/>
    <dbReference type="OMA" id="ANYENSY"/>
    <dbReference type="OrthoDB" id="3944408at2759"/>
    <dbReference type="PhylomeDB" id="B8LZB0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054505">
        <property type="entry name" value="Myb_DNA-bind_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22980">
        <property type="entry name" value="Myb_DNA-bind_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like DNA-binding" evidence="2">
        <location>
            <begin position="16"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED21663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="343" mass="38117" checksum="6097858E7C7039E8" modified="2009-03-03" version="1">MATIRRSKTMPTEGHATRFLYTILKQLDLKTIDWSLVATELEISNGHAARMRYSRFKQQMEGLTTTASKPAKPKKANGKPEYGKTTKQSTKGKSIYDKGKSFDKASGYESANYENSYTSDSTFKKRSAPDEFMKQESKMNYGVMGVEKMNSFTPVIYDPFANAASYWTPSGGPILSSDPATFPYMTMPDLHQQQQQFRVDPYANLYLAPMPPLHSGEDVNMAFNPGWAPQIFDHMFNNNEQFGQGHPKAAAPPTVTTAANPPEWNDQMDFCFSGCCQRPPPYPSPPSLSPDVPPTDQSGDTLMSAQPEPWVPPPQQNQWVAIKPEPGEEGGSDDIFVKVEADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZI3</accession>
    <name>B8LZI3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_093110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479028.1">
        <property type="nucleotide sequence ID" value="XM_002478983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZI3"/>
    <dbReference type="GeneID" id="8102555"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_093110"/>
    <dbReference type="eggNOG" id="ENOG502SUS8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053382_4_1_1"/>
    <dbReference type="InParanoid" id="B8LZI3"/>
    <dbReference type="OMA" id="YRTEWAR"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED22065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="159" mass="18605" checksum="C84B35DF43323B52" modified="2009-03-03" version="1">MSHELHYSSNNVRSFFDDFPDFVQDPSAPISAEFARLAAHRQWKKGARSKTYERNWSKCIRMEFDNFYGKEYTKLESWQNICTEVGIEPLSSVTKCKKALSKVNVNLVNLIDCRTTGEKPLLFPSLDALRKYTRKRGRAFPREEAKEDGFIKILLKRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8M090</accession>
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            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">TSTA_084180</name>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002478105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M090"/>
    <dbReference type="STRING" id="441959.B8M090"/>
    <dbReference type="GeneID" id="8101511"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_084180"/>
    <dbReference type="HOGENOM" id="CLU_482477_0_0_1"/>
    <dbReference type="InParanoid" id="B8M090"/>
    <dbReference type="OrthoDB" id="4227018at2759"/>
    <dbReference type="PhylomeDB" id="B8M090"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="360"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED21187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="565" mass="63511" checksum="B34507F7479F7F3A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0M4</accession>
    <name>B8M0M4_TALSN</name>
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        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="9" type="ORF">TSTA_086380</name>
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    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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        </lineage>
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    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="441959.B8M0M4"/>
    <dbReference type="GeneID" id="8110046"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_086380"/>
    <dbReference type="eggNOG" id="ENOG502RZ6Z">
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    </dbReference>
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    <dbReference type="InParanoid" id="B8M0M4"/>
    <dbReference type="OMA" id="AGCFPHR"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="PhylomeDB" id="B8M0M4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF76">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
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    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
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        <location>
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            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="682"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
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            <end position="637"/>
        </location>
    </feature>
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        <location>
            <begin position="685"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED21407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="770" mass="86497" checksum="45E8FA45E2CA650B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0N5</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002478336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0N5"/>
    <dbReference type="STRING" id="441959.B8M0N5"/>
    <dbReference type="GeneID" id="8110057"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_086510"/>
    <dbReference type="eggNOG" id="ENOG502S5CN">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061230_2_1_1"/>
    <dbReference type="InParanoid" id="B8M0N5"/>
    <dbReference type="OMA" id="EGEWALY"/>
    <dbReference type="OrthoDB" id="3928002at2759"/>
    <dbReference type="PhylomeDB" id="B8M0N5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049:SF1">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877477" evidence="1">
        <location>
            <begin position="17"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="212" mass="23851" checksum="13ACEB283A28CDD2" modified="2009-03-03" version="1">MVIGLLAITAIPTVTGVAFGVSEQRKANSRMQDEKRMAKFYMKVYCEGDSEKSRSLNGRRAVLRDTKVYLDHADPNIRKIPSHTVAAFFIAYPDDDNKRGDGLVSTISDNPPMLNWIYVDKDTLELKYGNRTQSIKHIVGHWGWTEDESGVLLNNKELWAAVEEEEDVWALYYDKNEDGLEGVVDPSKTVVEISIDRDLVVKPGENADASKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0Y9</accession>
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        <submittedName>
            <fullName evidence="6">PX domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_090080</name>
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    <organism evidence="6 7">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Talaromyces</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
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    <dbReference type="Proteomes" id="UP000001745">
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    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="5">
        <location>
            <begin position="168"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="4">
        <location>
            <begin position="488"/>
            <end position="603"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="658"/>
            <end position="722"/>
        </location>
    </feature>
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        <location>
            <begin position="735"/>
            <end position="785"/>
        </location>
    </feature>
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        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
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        <location>
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            <end position="673"/>
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    </feature>
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            <end position="683"/>
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            <end position="703"/>
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        <location>
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            <end position="751"/>
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    </feature>
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        <location>
            <begin position="752"/>
            <end position="766"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="973" mass="105607" checksum="12F7EB8E8DB3696F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1C4</accession>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="EED21820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="441959.B8M1C4"/>
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    <dbReference type="PhylomeDB" id="B8M1C4"/>
    <dbReference type="Proteomes" id="UP000001745">
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:glycerolipid metabolic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
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    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
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        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
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    <dbReference type="PANTHER" id="PTHR24185:SF4">
        <property type="entry name" value="SERINE HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G07870)-RELATED"/>
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        <property type="entry name" value="PNPLA"/>
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        <location>
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    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="537"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED21820.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="600" mass="66155" checksum="19D8AD627B11B316" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1U8</accession>
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        <submittedName>
            <fullName evidence="7">Hydroxyisocaproate dehydrogenase, putative</fullName>
        </submittedName>
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        <name evidence="7" type="ORF">TSTA_085570</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
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    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
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        <property type="protein sequence ID" value="EED21326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002478244.1"/>
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    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_019796_1_2_1"/>
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    <dbReference type="OMA" id="HHTRAAM"/>
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    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyoxylate reductase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
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        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
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    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
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        <property type="entry name" value="D-isomer_DH_CS1"/>
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        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF257">
        <property type="entry name" value="GLYOXYLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="52"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="121"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED21326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="329" mass="35861" checksum="60550D7D34602143" modified="2009-03-03" version="1">MRSQAALLIGEITHARPEWEQLSSRLTLKEFPFGTREEFLRNCKNGDYDDVVVIYRSNTSTKYTGRFDKELVSALPKSVKYIVHNGAGYDNIDVAVVTEAGIAVSSTPVAVNNATADVGIFLMIGALRQAHVPITSIRAGQWAGKSKLGHDPKGKVLGILGMGGIGREMAHRAKGFGMTIQYHNRSRLSPELEEGAKYVSFEELLASSDVFSLNLALNPSTRHIIGAKELAKMKDGVVIVNTARGALIDEKALVAAIESGKVGSAGLDVYENEPQVEEGLLKSDKVFLLPHIGTMTFETQKEMELLVLENLRSAVEKGELVTQIPEQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2E4</accession>
    <name>B8M2E4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PfkB family carbohydrate kinase (Mak32), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_088440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478571.1">
        <property type="nucleotide sequence ID" value="XM_002478526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2E4"/>
    <dbReference type="FunCoup" id="B8M2E4">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M2E4"/>
    <dbReference type="GeneID" id="8106941"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_088440"/>
    <dbReference type="eggNOG" id="ENOG502RXN8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032834_0_0_1"/>
    <dbReference type="InParanoid" id="B8M2E4"/>
    <dbReference type="OMA" id="VIKSWNT"/>
    <dbReference type="OrthoDB" id="497927at2759"/>
    <dbReference type="PhylomeDB" id="B8M2E4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01943">
        <property type="entry name" value="MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034094">
        <property type="entry name" value="Mak32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098:SF2">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="1">
        <location>
            <begin position="53"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="388" mass="43596" checksum="6106ED8800B8C09A" modified="2009-03-03" version="1">MSDENHRSEVDFCTLGMFIIDDIEFKPPTPSVYGIIGGAGSFAIVGARIVAGKEHGKAVSWIVDTGSDFPEDMMDTILSWNTGCAIREDKDRLTTRAWNGYGENEKRDFKYLTPKKRLEPYMLSDAQLLSKTFHMVCSSERCIHIVQEILHRRELASSNQSARPIFVWEPVPDLCAPEEQEKFLTACRVVDLVSPNELELGMMFGRPGWKETNEIDRELVQKILQSGIGPENKGALVIRAGKDGSYSYSKGQKGLWLPAYHQPRPDQKSKVVDPTGAGNSFLGALAQGMISNDREPGRIMDDILSKSDEWDKIKARWGNNGQIPQALICATVTAGFVVEQIGVPTISTTADGRETWNGTEFNERLRNYTQWLCETFEQFPQDHEWVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2R9</accession>
    <name>B8M2R9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyl-D-glucosamine kinase</fullName>
            <ecNumber evidence="2">2.7.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GlcNAc kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_094200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic-type N-acetylglucosamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.59" evidence="2"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479137.1">
        <property type="nucleotide sequence ID" value="XM_002479092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2R9"/>
    <dbReference type="STRING" id="441959.B8M2R9"/>
    <dbReference type="GeneID" id="8103748"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_094200"/>
    <dbReference type="eggNOG" id="ENOG502QS2J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022562_0_0_1"/>
    <dbReference type="InParanoid" id="B8M2R9"/>
    <dbReference type="OMA" id="PCNLTDG"/>
    <dbReference type="OrthoDB" id="311172at2759"/>
    <dbReference type="PhylomeDB" id="B8M2R9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016835">
        <property type="term" value="F:carbon-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045127">
        <property type="term" value="F:N-acetylglucosamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046348">
        <property type="term" value="P:amino sugar catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009750">
        <property type="term" value="P:response to fructose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05007">
        <property type="entry name" value="SIS_Etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000014">
        <property type="entry name" value="N-acetylmuramic acid 6-phosphate etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00068">
        <property type="entry name" value="MurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005488">
        <property type="entry name" value="Etherase_MurQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005486">
        <property type="entry name" value="Glucokinase_regulatory_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040190">
        <property type="entry name" value="MURQ/GCKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00274">
        <property type="entry name" value="N-acetylmuramic acid 6-phosphate etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003915">
        <property type="entry name" value="PRK05441.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009222">
        <property type="entry name" value="PRK12570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088">
        <property type="entry name" value="GLUCOKINASE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088:SF4">
        <property type="entry name" value="GLUCOKINASE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22645">
        <property type="entry name" value="GKRP_SIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01272">
        <property type="entry name" value="GCKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SIS" evidence="7">
        <location>
            <begin position="60"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED22174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="688" mass="72771" checksum="3ECBCD96E1922789" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8M328</accession>
    <name>B8M328_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arrestin (Or S-antigen) domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_092470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478967.1">
        <property type="nucleotide sequence ID" value="XM_002478922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M328"/>
    <dbReference type="FunCoup" id="B8M328">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M328"/>
    <dbReference type="GeneID" id="8099428"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_092470"/>
    <dbReference type="eggNOG" id="ENOG502QS9U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026015_0_0_1"/>
    <dbReference type="InParanoid" id="B8M328"/>
    <dbReference type="OMA" id="MVVAEEW"/>
    <dbReference type="OrthoDB" id="3832628at2759"/>
    <dbReference type="PhylomeDB" id="B8M328"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024391">
        <property type="entry name" value="LDB19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF76">
        <property type="entry name" value="PROTEIN LDB19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13002">
        <property type="entry name" value="LDB19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LDB19 N-terminal" evidence="2">
        <location>
            <begin position="148"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED22004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="536" mass="58644" checksum="C0E7126B945B0809" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8M373</accession>
    <name>B8M373_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_092950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479012.1">
        <property type="nucleotide sequence ID" value="XM_002478967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M373"/>
    <dbReference type="GeneID" id="8099473"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_092950"/>
    <dbReference type="HOGENOM" id="CLU_930986_0_0_1"/>
    <dbReference type="InParanoid" id="B8M373"/>
    <dbReference type="OMA" id="QMDMENE"/>
    <dbReference type="OrthoDB" id="4226243at2759"/>
    <dbReference type="PhylomeDB" id="B8M373"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="296" mass="33484" checksum="D0155BB32ED0090A" modified="2009-03-03" version="1">MYPFKSISKAVMPSLRAAQVSMAFPKAHSLPNLHAAQAPPVKLSPGNGYTCQKSVLQGQPDSSALIPKAKLPTPCPYPTIYIPNPRQYTKEEYAELALHFENRVKGQWKKVWFGLYQVEGAKESTHAAEIRKLYAGAGMGESLRKPGNQDTTIYFRGYWEFTGLGRLSHVLVESGPTDFWPVIGRLKMYDGIALDNMQFISIMLKEYEKQVDQLSELYQFLEGMQIPHHVEPTEEHIKTVMHGFRERSGNIAQALIDLDLEMGAMQRNINQEAAQLHGSSLERVETLHFRKEVLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8M478</accession>
    <name>B8M478_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_040150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481255.1">
        <property type="nucleotide sequence ID" value="XM_002481210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M478"/>
    <dbReference type="STRING" id="441959.B8M478"/>
    <dbReference type="GeneID" id="8109774"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_040150"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1253315_0_0_1"/>
    <dbReference type="InParanoid" id="B8M478"/>
    <dbReference type="OMA" id="RETCTID"/>
    <dbReference type="OrthoDB" id="3563815at2759"/>
    <dbReference type="PhylomeDB" id="B8M478"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="221" mass="25456" checksum="CF7940389E755ABC" modified="2009-03-03" version="1" fragment="single">INDALNTRNRPSSTLIHRLPLNLDVLVWREGGTRYPGKWKGPYKLISINRETCTIDLLNGPTKFRSTVVKLYHKDDDPKQENTNNNDKAEPYSAPTAPLIELSNLRSHYMNQITPNLNHNAHNANAAYHLDIRMILRTYDESRKKEVNGLLERDIPPEARIYGFRFVDEIKNKGTNKVFEKLQLVVQAYNDKDKEFILTQSPTIQRSSQRLILCIGASKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4C6</accession>
    <name>B8M4C6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-L-fucosidase</fullName>
            <ecNumber evidence="2">3.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_024450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 29 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.51" evidence="2"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479555.1">
        <property type="nucleotide sequence ID" value="XM_002479510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4C6"/>
    <dbReference type="STRING" id="441959.B8M4C6"/>
    <dbReference type="GeneID" id="8097976"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_024450"/>
    <dbReference type="eggNOG" id="KOG3340">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_759053_0_0_1"/>
    <dbReference type="InParanoid" id="B8M4C6"/>
    <dbReference type="OMA" id="GENFICD"/>
    <dbReference type="OrthoDB" id="6039950at2759"/>
    <dbReference type="PhylomeDB" id="B8M4C6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057739">
        <property type="entry name" value="Glyco_hydro_29_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030:SF37">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase family 29 N-terminal" evidence="6">
        <location>
            <begin position="71"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED19121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="365" mass="40754" checksum="C51230B7A6948284" modified="2009-03-03" version="1">MTVTNSNDQNYLTVADTLVVSTSSRSSNYVDLVVPGNLTRLAPGQSAIVQVKVKNKAGVAADTLCTVDIVATYGQAYDSLNNHWNPDWYNNVKSGIFIHWGPYSAPAYGSVAPNEDYAEWYWMRQHQPSYKTQINQYHLEIYGENFICDDFMSNFTGAAWDPKEWMNLIADSGTHYFALVTKHHNGFALFDFLLMLACGLPSIMVQKETSLENHLQKLKNIILEFVVGLRIATSCSILDPCTTAPFQELCKQVFATLAPGFERMTKASYDTRYWSVTPGTGQIRYTTTADAFCIHYMGAPPLLIPISDPVPWLPGDTVTVLGGNKNDTIVPVTKSDDVLNLTLTEDIVQADTYVWSFKLSYTSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8M550</accession>
    <name>B8M550_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DUF221 domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_029330</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480090.1">
        <property type="nucleotide sequence ID" value="XM_002480045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M550"/>
    <dbReference type="GeneID" id="8099052"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_029330"/>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009187_1_0_1"/>
    <dbReference type="InParanoid" id="B8M550"/>
    <dbReference type="OMA" id="VVCAWAF"/>
    <dbReference type="OrthoDB" id="2150324at2759"/>
    <dbReference type="PhylomeDB" id="B8M550"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF149">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="599"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="647"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="678"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="39"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="213"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="388"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="841"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="945"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="849"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="877"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="896"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED19656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="966" mass="109430" checksum="D2D8499169ACA284" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8M589</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="1" type="ORF">TSTA_029690</name>
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    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="AlphaFoldDB" id="B8M589"/>
    <dbReference type="GeneID" id="8106536"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_029690"/>
    <dbReference type="HOGENOM" id="CLU_1769344_0_0_1"/>
    <dbReference type="InParanoid" id="B8M589"/>
    <dbReference type="PhylomeDB" id="B8M589"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED19695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="147" mass="17107" checksum="EFE6CE5F15FF9A71" modified="2009-03-03" version="1">MNGLTIKIHSEVWIYINPDFEMPANGAAEPSATEAADKTKAYGKRLLEPEMPVQGAEETEATFSLRQTKRSTRMHSSVENEVDVREILVKLKKRHMPDMEKEQNAIFDQLMELKAGPSNQRQINAWIKSWITLYNRAEEYKVQDWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5I4</accession>
    <name>B8M5I4_TALSN</name>
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        <submittedName>
            <fullName evidence="4">Nucleoside-diphosphate-sugar epimerase, putative</fullName>
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    <gene>
        <name evidence="4" type="ORF">TSTA_031380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Trichocomaceae</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED19878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5I4"/>
    <dbReference type="STRING" id="441959.B8M5I4"/>
    <dbReference type="GeneID" id="8107749"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_031380"/>
    <dbReference type="eggNOG" id="KOG1371">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_007383_19_0_1"/>
    <dbReference type="InParanoid" id="B8M5I4"/>
    <dbReference type="OMA" id="KMMCEYL"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="PhylomeDB" id="B8M5I4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05238">
        <property type="entry name" value="Gne_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF3">
        <property type="entry name" value="ADP-L-GLYCERO-D-MANNO-HEPTOSE-6-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED19878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="319" mass="34970" checksum="C2F7D167BF19FD9D" modified="2009-03-03" version="1">MNILITGAAGFIGQLLATELLNDPAYKLVLVDIVDPPIQSGVKYPQNAKIIKTDLVADNLETLVHESAPDAVYAFHGIMSSGSEANFELGMKANVDATRALLEALRKKAPPGVRFIYSSSQAVYGQPLPKTVTDEVIPTPESSYGAAKLICEALVNEYTRRGFIMGFTLRFPTISVRPGKPTAAASSFLSGMIREPLNGQEAIIPLEDRSFESWLCSPRTLVRNLIFTLSLPGDCVPPHIRQINVPGICVTIQDMMDALEKVGGKDKLGLLKEKEDPVIKRIVYSWPTRFDNSQAIGLGFQRDESFEQAVRDFKESVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5L7</accession>
    <name>B8M5L7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_031720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480345.1">
        <property type="nucleotide sequence ID" value="XM_002480300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5L7"/>
    <dbReference type="GeneID" id="8107781"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_031720"/>
    <dbReference type="eggNOG" id="ENOG502S1B6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019843_0_0_1"/>
    <dbReference type="InParanoid" id="B8M5L7"/>
    <dbReference type="OMA" id="RMFWGDP"/>
    <dbReference type="OrthoDB" id="5210591at2759"/>
    <dbReference type="PhylomeDB" id="B8M5L7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF59">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="38"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="319" mass="36260" checksum="40D4F36E41FEFF67" modified="2009-03-03" version="1">MLMGFSASDNCFRNVVQLLFPPTVYLRSTRILSSRVYRVYHLNLSNGHQLVLRASPPPAIPLLRRERASLETEMRALTILAPINSPCIPRLYRHISRDASPSVSLLVRQYIDGIPLAEMQDQLSAKDLNDVDRQLGSLIKAVGQQVSTAFGPLSKVAAGTGHRHWREAFVTLFEEVLRDAEDMFIHLPYHQIRREVSRLSAVLDEVTTPRLVVMNLGRPSEVLLDPSTRQLCGLLDFGSALWGDIMLAEIFESPSDALLAEFGSFPQSRSIRSLLYSCYRHVYKITELYYRNSNNAIEMEVRRRLTDLLQTLTMTELPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5Q9</accession>
    <name>B8M5Q9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione S-transferase GstA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_032120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480387.1">
        <property type="nucleotide sequence ID" value="XM_002480342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5Q9"/>
    <dbReference type="STRING" id="441959.B8M5Q9"/>
    <dbReference type="GeneID" id="8099825"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_032120"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_22_0_1"/>
    <dbReference type="InParanoid" id="B8M5Q9"/>
    <dbReference type="OMA" id="LFWESST"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="PhylomeDB" id="B8M5Q9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000172">
        <property type="entry name" value="Glutathione S-transferase GstA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="126" mass="14425" checksum="BF2FB1C1880B8C6B" modified="2009-03-03" version="1">MAAQRTPDITLYTAQTPNGIKISIALEELGLPYKVKKLEFSKNEQKEPWFLEINPNGRIPAITDTFTDGKTINIFESGSILQYLADNYDPEYKISYPRGSREYYEVGNWLFFMNAGVGPMQGKRYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5T8</accession>
    <name>B8M5T8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidase ustYa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_033120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480499.1">
        <property type="nucleotide sequence ID" value="XM_002480454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5T8"/>
    <dbReference type="STRING" id="441959.B8M5T8"/>
    <dbReference type="GeneID" id="8105050"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_033120"/>
    <dbReference type="eggNOG" id="ENOG502SP97">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042941_1_1_1"/>
    <dbReference type="InParanoid" id="B8M5T8"/>
    <dbReference type="OMA" id="ILHGFHN"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="PhylomeDB" id="B8M5T8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF6">
        <property type="entry name" value="OXIDASE USTYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED20065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="32119" checksum="45D25D2C8E6D39AF" modified="2009-03-03" version="1">MFFQGYLKVPNSGRAEAEEYGGDVEDKLINGDSSEISKITAKSNRLQIPMVLSIVVNLFLLGIMIFRHESPHPLYRSEYAGLARTVPRPWGPNTAVNDTEQDALWDATSYDLGNIALSDTYARSKGLPRAQRFPWDNKKGIYLINAYHNLHCVKTMRTALIEFRDGKPQSSPFGHLEHCLLVLRDEAMCNADDTPRYTGFQPNQKSGLGQVRMCRDFEQLEQWARDHTACWRHVGEIHEEGFRELDRYRFCPEGSPYKEMSETMYLKGDWWKQYKDGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6C4</accession>
    <name>B8M6C4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CLPTM1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_026100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479733.1">
        <property type="nucleotide sequence ID" value="XM_002479688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6C4"/>
    <dbReference type="STRING" id="441959.B8M6C4"/>
    <dbReference type="GeneID" id="8108022"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_026100"/>
    <dbReference type="eggNOG" id="KOG2489">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019907_2_0_1"/>
    <dbReference type="InParanoid" id="B8M6C4"/>
    <dbReference type="OMA" id="TLWAHFY"/>
    <dbReference type="OrthoDB" id="378564at2759"/>
    <dbReference type="PhylomeDB" id="B8M6C4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF0">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="501"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="598"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="620"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED19299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="635" mass="72286" checksum="BB509476F6826F36" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8M761</accession>
    <name>B8M761_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_035100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480715.1">
        <property type="nucleotide sequence ID" value="XM_002480670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M761"/>
    <dbReference type="GeneID" id="8107460"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_035100"/>
    <dbReference type="HOGENOM" id="CLU_2428560_0_0_1"/>
    <dbReference type="InParanoid" id="B8M761"/>
    <dbReference type="OrthoDB" id="4207519at2759"/>
    <dbReference type="PhylomeDB" id="B8M761"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED20281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="91" mass="10175" checksum="2894A83FB1FD83C4" modified="2009-03-03" version="1">MAPSQSCSTCDSHGIERIRSVKIVGVHRFKDLSISYGVNISDITCYSMIDNREWVIAIEAVSSTGWALPLCIVFKAKKYTRLGWFEDLSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8M798</accession>
    <name>B8M798_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Life-span regulatory factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_035450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480752.1">
        <property type="nucleotide sequence ID" value="XM_002480707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M798"/>
    <dbReference type="GeneID" id="8107495"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_035450"/>
    <dbReference type="eggNOG" id="ENOG502S7ZU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099513_2_0_1"/>
    <dbReference type="InParanoid" id="B8M798"/>
    <dbReference type="OMA" id="CLVCDRQ"/>
    <dbReference type="OrthoDB" id="2563506at2759"/>
    <dbReference type="PhylomeDB" id="B8M798"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024368">
        <property type="entry name" value="Ecl1/2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12855">
        <property type="entry name" value="Ecl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15051" checksum="875E2677ECDC6713" modified="2009-03-03" version="1">MSADWSLDFCLVCDQQTSGAGPYCSQSCRLADLDQNGSESSVSSYPVYLSSKSTLQPKTSSSSTAGRQSIGKRTTSSFSSTSSNDQSSSLTSTSSQTSLSSLTSTLTPSAALSNQVRHELQDYSKSFDQVRDWKRRLTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7A7</accession>
    <name>B8M7A7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_035530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480761.1">
        <property type="nucleotide sequence ID" value="XM_002480716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7A7"/>
    <dbReference type="GeneID" id="8107503"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_035530"/>
    <dbReference type="HOGENOM" id="CLU_2198770_0_0_1"/>
    <dbReference type="InParanoid" id="B8M7A7"/>
    <dbReference type="OrthoDB" id="5416097at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED20327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="108" mass="12389" checksum="3C468ABCDF61AED9" modified="2009-03-03" version="1">MWGAGHFALRSMEKLDFKTLKVQFYWERKLLNGVTEIKLLTEPKSTPVVSGDTFTLTTPDPDRLPLPSWSLLEIQWHLQRIVATSGTAEAQDYPDSDDDFDDIEECLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7Z4</accession>
    <name>B8M7Z4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Anion exchange family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_032150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480390.1">
        <property type="nucleotide sequence ID" value="XM_002480345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7Z4"/>
    <dbReference type="FunCoup" id="B8M7Z4">
        <property type="interactions" value="418"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M7Z4"/>
    <dbReference type="GeneID" id="8099828"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_032150"/>
    <dbReference type="eggNOG" id="KOG1172">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002289_7_1_1"/>
    <dbReference type="InParanoid" id="B8M7Z4"/>
    <dbReference type="OMA" id="RRAPFYW"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="PhylomeDB" id="B8M7Z4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080139">
        <property type="term" value="F:borate efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.570:FF:000003">
        <property type="entry name" value="Anion exchange family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF82">
        <property type="entry name" value="BORON TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="481"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="9">
        <location>
            <begin position="98"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="9">
        <location>
            <begin position="272"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="620"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="624"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="681"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED19956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="691" mass="76455" checksum="6BB98CD2C90CAE02" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8M875</accession>
    <name>B8M875_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_032900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480471.1">
        <property type="nucleotide sequence ID" value="XM_002480426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M875"/>
    <dbReference type="GeneID" id="8105029"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_032900"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_1_1_1"/>
    <dbReference type="InParanoid" id="B8M875"/>
    <dbReference type="OMA" id="QNNFGIV"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="PhylomeDB" id="B8M875"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF28">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877461" description="FAD-binding PCMH-type domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="56"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED20037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="492" mass="52860" checksum="34B8705A9F77A3B2" modified="2009-03-03" version="1">MRHYLTVLGLVLLPICCTASFVTDCAALSTLLPGKVFYTNSTVYDSSVKSYYFVEERLNPTCIVRPTSTSDVAIVVKYTADCPSALLSIKGGGHSPNIGAANADVGVTLDLRTLNAVSIQSGGLITSVGAGALWQEVYRVLDTYGLAAVGGRVATVGVGGLITGGGLSAFSPEHGFACDNVVNMELVLASGAIVNANETSHADLFAALKGGQNNFGIVTRFDIRSFQQPDYWGGGVEYTSDSDEDQILAFAKFKDPENFDPHAEIEQSFLYTAADNSRISSNNMFYTKPVVNASALADFTAIEPQLSNTMRISNTTDFAKEMAMYQPADTLAVYATTTFNVSLPALQSILGIWNTSVHELSHIKSLLAVLTFQAIPPVPPASGPQNSLGFTPNSHPERDLVLCLLSNYWTDASASAEIQAATQSLLEEIEAITQKDGVDVRYKYMNYAAKWQDPIMSYGTTQVEKLREVAAKYDPSGFFQAKVPGGFKLSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8M881</accession>
    <name>B8M881_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_036200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480828.1">
        <property type="nucleotide sequence ID" value="XM_002480783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M881"/>
    <dbReference type="STRING" id="441959.B8M881"/>
    <dbReference type="GeneID" id="8101891"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_036200"/>
    <dbReference type="eggNOG" id="KOG0684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018012_4_2_1"/>
    <dbReference type="InParanoid" id="B8M881"/>
    <dbReference type="OMA" id="FWTISHI"/>
    <dbReference type="OrthoDB" id="3366823at2759"/>
    <dbReference type="PhylomeDB" id="B8M881"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11040">
        <property type="entry name" value="CYP7_CYP8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053007">
        <property type="entry name" value="CYP450_monoxygenase_sec-met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47582">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47582:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002874910" evidence="8">
        <location>
            <begin position="19"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED20394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="526" mass="59059" checksum="816C298BF99D546C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8S7</accession>
    <name>B8M8S7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_038030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481024.1">
        <property type="nucleotide sequence ID" value="XM_002480979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8S7"/>
    <dbReference type="GeneID" id="8109798"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_038030"/>
    <dbReference type="HOGENOM" id="CLU_2051230_0_0_1"/>
    <dbReference type="InParanoid" id="B8M8S7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877376" evidence="1">
        <location>
            <begin position="24"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="120" mass="13159" checksum="7E9B8C7A92C95A6D" modified="2009-03-03" version="1">MLVWFGVSDYVIVGVWWTAKVDGVEGGGGYDDVVDDDEEFVDTPCDEDEGVVGDVLDDGDDDEVVALVAIARAPEEICEEVCEPAAEDALKADCALNAERKFARNGRFVDILEESEWNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8S9</accession>
    <name>B8M8S9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_038050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481026.1">
        <property type="nucleotide sequence ID" value="XM_002480981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8S9"/>
    <dbReference type="STRING" id="441959.B8M8S9"/>
    <dbReference type="GeneID" id="8102180"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_038050"/>
    <dbReference type="eggNOG" id="KOG2029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_490099_0_0_1"/>
    <dbReference type="InParanoid" id="B8M8S9"/>
    <dbReference type="OrthoDB" id="4226192at2759"/>
    <dbReference type="PhylomeDB" id="B8M8S9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="38"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED20592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="470" mass="53400" checksum="FBF7549C7D6F9C7C" modified="2009-03-03" version="1">MLSCFSRSMIERGGWVYLPLGDLPRPDRRQNYPEGKNGINLSFFIHGRGSFLQKALLGFYRTVLFQLLDHLSSHEKKPEALSKLEESFKRQCDSRGPLGKSWHWETAQLAKEFQLALREVEKNGPVYLYVDALDECGEEEAKRFAATIEKIIEAFADGKLHICFSCRHYPPLMLEDLSDMHIGGYVHSQLNPFAMPEIADKIISLSVGNFMWTHLVVETLPGLGELYGDLLQAMLGDENSLRLVQWICFADRPLSLEELRWAMFVEAHPEAKSLGECRVAPDFPCDCANQCDCDVIERRVKGLSRGLIEVTHAAITDSGSNRTAQFIHGSVQEFFLDKGAFLRLHHSISSSRSLDHVKSKARNSITQTCIRYCRMKEIRQAIAKFETNSAAGLALAAGPLQRGFPFLHYAVMTWAQHENESSPAAYFHWRKDSELLDSLLRVFPDVSEQHAVKRKRSQWSFDKVHLATKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9H5</accession>
    <name>B8M9H5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AMID-like mitochondrial oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_115340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481727.1">
        <property type="nucleotide sequence ID" value="XM_002481682.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481728.1">
        <property type="nucleotide sequence ID" value="XM_002481683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9H5"/>
    <dbReference type="STRING" id="441959.B8M9H5"/>
    <dbReference type="GeneID" id="8101344"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_115340"/>
    <dbReference type="eggNOG" id="KOG2495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019845_6_1_1"/>
    <dbReference type="InParanoid" id="B8M9H5"/>
    <dbReference type="OMA" id="PIPFKQS"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="47"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED17735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="420" mass="45045" checksum="0AEBC8B8C7DB5111" modified="2009-03-03" version="1">MTDLTNNQRIYLSASLVALPLFVLWSWRQRRLNAIEAAEMAQTSPKTVVVIGASWAGINTTHGLLKEVPSAKVVLINPSDEFYFNIASPRLVSKPGEIPREKYIYPIAPLFDKYPNAKKNFEFVQGKATAIDLEGKNVSVQESTGTSRTIAYDYLVIASGSTSNATTGTGSFQVPFKQSSSTKVEAELKTAQETIKSAKSIIIGGAGAVGVEFAGELAEARPDLEITLVTNTDNVLFGLREPTRQKAAKILKQKKVKILTNKAVTSAAPDSTTGKWTVTTADGQTLTADIYVSTVGVVPNNEFIPASLLNKDGWVEVDTHFASKANSSVYAVGDITHYSARLVSRVAGQVSVLISNLKADITGKGKRGVYKTEQSLMVVMPMGKSTGTGQLGNFTPPGFLVSFVKGKDYFTGSGKKFIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9V3</accession>
    <name>B8M9V3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Autophagy-related E2-like conjugation enzyme ATG3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_118710</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Monomer. Interacts with ATG8 through an intermediate thioester bond through the C-terminal Gly of ATG8. Also interacts with the 40 amino acid C-terminal region of the E1-like ATG7 enzyme. Also interacts with the ATG12-ATG5 conjugate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG3 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482097.1">
        <property type="nucleotide sequence ID" value="XM_002482052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9V3"/>
    <dbReference type="FunCoup" id="B8M9V3">
        <property type="interactions" value="1078"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M9V3"/>
    <dbReference type="GeneID" id="8099795"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_118710"/>
    <dbReference type="eggNOG" id="KOG2981">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027518_2_0_1"/>
    <dbReference type="InParanoid" id="B8M9V3"/>
    <dbReference type="OMA" id="HCPTWSW"/>
    <dbReference type="OrthoDB" id="1584384at2759"/>
    <dbReference type="PhylomeDB" id="B8M9V3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="105"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED18105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="379" mass="42658" checksum="88E26E2A4A44064C" modified="2009-03-03" version="1">MSKNLIHQTWSTWRDWITPVTHTSTFRETGKITPEEFVAAGDYLVFKFPSWQWADASTPAQRVPFLPPGKQYLVTRGVPCHRRLNDNFAGDLQEDVIIKDMLRAGPGSGGGDGEDDGWLQTGGKREYADTQEAKRKDVRTVDEAGNVSEQGEDEDEIPDMEDDDDDEEAIIRDPSGASGTTAPLRTYNLYITYANYYRTPRLYLSGYLSPSEPLPPHLMMEDIVGDYKDKTVTLEDFPWFDTSVPMATVHPCQHASVMKILLDRADAALKIRRQKLKKARSAEDASNIKFDSGLEGLVDDTNNLSLTERQRKLQQQDGGSSANNNNMMGDEWEVLQNDGNQSEEDEFQSAIRVDQYLVVFLKFISSVTPGIEHDFTMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9Z0</accession>
    <name>B8M9Z0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_119060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482134.1">
        <property type="nucleotide sequence ID" value="XM_002482089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9Z0"/>
    <dbReference type="GeneID" id="8104356"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119060"/>
    <dbReference type="HOGENOM" id="CLU_2216297_0_0_1"/>
    <dbReference type="InParanoid" id="B8M9Z0"/>
    <dbReference type="OrthoDB" id="5103939at2759"/>
    <dbReference type="PhylomeDB" id="B8M9Z0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED18142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="107" mass="12408" checksum="7E1C214F5C65B0C1" modified="2009-03-03" version="1" fragment="single">TLLNLIIIQRLPFSCVEWPESHAFVKALNRESPSFIPIYDSIMTEWIAEHFIQSRDTMRKVLQSAKTNIHLTVDIWTSPSHSLLLEICASFADIQDKYQNPLIVLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8MA03</accession>
    <name>B8MA03_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AP-2 adaptor complex subunit mu, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_119190</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482147.1">
        <property type="nucleotide sequence ID" value="XM_002482102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MA03"/>
    <dbReference type="FunCoup" id="B8MA03">
        <property type="interactions" value="168"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MA03"/>
    <dbReference type="GeneID" id="8104369"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119190"/>
    <dbReference type="eggNOG" id="KOG0938">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026996_5_2_1"/>
    <dbReference type="InParanoid" id="B8MA03"/>
    <dbReference type="OMA" id="VWKIPRI"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="PhylomeDB" id="B8MA03"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09251">
        <property type="entry name" value="AP-2_Mu2_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14836">
        <property type="entry name" value="AP2_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043532">
        <property type="entry name" value="AP2_Mu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043512">
        <property type="entry name" value="Mu2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0168">Coated pit</keyword>
    <keyword evidence="2" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="8">
        <location>
            <begin position="170"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED18155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="438" mass="49413" checksum="F781104894BB1135" modified="2009-03-03" version="1">MISGILIFNQKGENLIFRAFRNDCRPRLADIFRIQVISNPQVRSPILTLGSTTFSHVKHENIYLVVVTKSNANAALVFEFLYRFIVLGRGYFGKFDEEAVKNNFVLVYELLDEIIDFGYPQNTETDTLKMYITTEGVKSAIANSAQDSSKITMQATGALSWRRADIKYRKNEAFVDVIEDVNLLMSATGTVLRADVHGQIIMRAYLSGTPECKFGLNDRLLLDGDDSSSAGNRNGRTKATRAAAGSVTLEDCQFHQCVKLGRFDADRTISFVPPDGEFELMRYRATENINLPFKVHPIVREIGTTKVEYSVAIKANYGAKLFASNVVVRIPTPLNTAKITERTTQGKAKYEPEHNNIVWKIARFTGQSEYVLTAEATLTSMTHQKAWSRPPLSLSFNLLMFTSSGLLVRYLKVFEKGNYSSVKWVRYMTRAGSYEIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B8MA90</accession>
    <name>B8MA90_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Transcription elongation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSTA_123210</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the TFS-II family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482584.1">
        <property type="nucleotide sequence ID" value="XM_002482539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MA90"/>
    <dbReference type="FunCoup" id="B8MA90">
        <property type="interactions" value="967"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MA90"/>
    <dbReference type="GeneID" id="8108236"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_123210"/>
    <dbReference type="eggNOG" id="KOG1105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037637_1_1_1"/>
    <dbReference type="InParanoid" id="B8MA90"/>
    <dbReference type="OMA" id="RFVVMTH"/>
    <dbReference type="OrthoDB" id="44867at2759"/>
    <dbReference type="PhylomeDB" id="B8MA90"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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    <sequence length="296" mass="32922" checksum="A0743E1AF46FFC0C" modified="2009-03-03" version="1">MDAKEIEFKAKALTKAATSSEPPANIINILKELQKGVRPTEDLLRSTRIGIVVNKLKQHKAQDVARLSSEIVSKWRSEVNKQKSNGSPNPHRSSTPRTGTASPAPASTPGDRKSTVPPEKRSWKADGVDTNVTNNKVRDSCLGLMYDGLSFMSTELPKVVLAKAIAVEAAAFTSFGPETKEQYKTKIRSLFQNLKNKSNPQLRQRVLSNEVTPEKFVKMTHEELKSDERRALDEKIHKENMDKAMVAQAERSISSSLQCGKCGQRKVTYTEAQTRSADEPMTLFCTCLNCGKSWKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAK0</accession>
    <name>B8MAK0_TALSN</name>
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        <submittedName>
            <fullName evidence="6">NRPS-like enzyme, putative</fullName>
        </submittedName>
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        <name evidence="6" type="ORF">TSTA_112570</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED17424.1"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
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        <property type="entry name" value="ACP-like_sf"/>
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        <property type="entry name" value="Adenylate-forming_Reductase"/>
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        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
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        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
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        <property type="entry name" value="PP-bd_ACP"/>
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        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
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        <property type="entry name" value="AMP-binding_C_3"/>
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        <property type="entry name" value="NAD_binding_4"/>
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        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
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            <begin position="45"/>
            <end position="351"/>
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        <location>
            <begin position="575"/>
            <end position="630"/>
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        <location>
            <begin position="694"/>
            <end position="956"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED17424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1110" mass="123562" checksum="4B8F040E45170A2F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAW3</accession>
    <name>B8MAW3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">D-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="11">1.1.99.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSTA_115950</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate. Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-malate + A = oxaloacetate + AH2</text>
            <dbReference type="Rhea" id="RHEA:67460"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15588"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:67461"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.39" evidence="11"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481795.1">
        <property type="nucleotide sequence ID" value="XM_002481750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAW3"/>
    <dbReference type="FunCoup" id="B8MAW3">
        <property type="interactions" value="537"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MAW3"/>
    <dbReference type="GeneID" id="8099622"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_115950"/>
    <dbReference type="eggNOG" id="KOG1232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017779_4_1_1"/>
    <dbReference type="InParanoid" id="B8MAW3"/>
    <dbReference type="OMA" id="YNEDWMR"/>
    <dbReference type="OrthoDB" id="5332616at2759"/>
    <dbReference type="PhylomeDB" id="B8MAW3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051990">
        <property type="term" value="F:(R)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2190:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000053">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051264">
        <property type="entry name" value="FAD-oxidored/transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716:SF1">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="16">
        <location>
            <begin position="112"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EED17803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="544" mass="59889" checksum="CB913B7E7AB928F6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MC14</accession>
    <name>B8MC14_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CorA family metal ion transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_121960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482452.1">
        <property type="nucleotide sequence ID" value="XM_002482407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MC14"/>
    <dbReference type="FunCoup" id="B8MC14">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MC14"/>
    <dbReference type="GeneID" id="8105482"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_121960"/>
    <dbReference type="eggNOG" id="ENOG502QPTQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007127_6_1_1"/>
    <dbReference type="InParanoid" id="B8MC14"/>
    <dbReference type="OMA" id="QRANTME"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="PhylomeDB" id="B8MC14"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000006">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.20:FF:000002">
        <property type="entry name" value="Cora family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF55">
        <property type="entry name" value="MAGNESIUM TRANSPORTER ALR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="589"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="624"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="86"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED18460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="651" mass="73564" checksum="C2DAB766BA67153F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8MC58</accession>
    <name>B8MC58_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_122370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482496.1">
        <property type="nucleotide sequence ID" value="XM_002482451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MC58"/>
    <dbReference type="STRING" id="441959.B8MC58"/>
    <dbReference type="GeneID" id="8097702"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_122370"/>
    <dbReference type="eggNOG" id="ENOG502RQEP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_605454_0_0_1"/>
    <dbReference type="InParanoid" id="B8MC58"/>
    <dbReference type="OrthoDB" id="5431097at2759"/>
    <dbReference type="PhylomeDB" id="B8MC58"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="490" mass="53274" checksum="D853168A04D2B2F1" modified="2009-03-03" version="1">MSAATPAPPPGDNNLNSHPPGHNINLPRFHPIAINPNVPGSTAPGPPPYHRSYGSPYSDHPPPHHASTGPLPPPLPPAPASHQYQPQHQQHSQQPGPPSRPSSHPPLLPVPVASQLDQIEARLRQIEQEEASRAAARAHMLALRRREDEEFRMVTERAEAEEEELRRRRKRLKRESMGLMDGQMESPPAPTPRRLSETSAATTLAFFKQQTPPEPRPSDMRAPPQQQAQAPHHPSPPTIIQQPTPMAPTPSTSIMSNPQGNTFRKKQKYTIKNAEAWGERHGRPATYDAEGRALWKRPSDGRLVYLDCPAPDCGKSDFVTLHGFMCHLTKKHKDRTLGSQSRALEVCGTVYDPNAPRPQRPSLKRDSAGNSRGGSVHTEGDEEEDTYSSVASDIHDDNTTNFNNHHSNVPSPREDGVKKEAADSPVTSSAVVNEVSSNKASIASMIDNAVTSSDQWVKKSSTPDDGPAVATTTAEDAAAAAVLAGQAIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCC9</accession>
    <name>B8MCC9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="2 12">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_123050</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="10 12">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="12">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="2 12"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482567.1">
        <property type="nucleotide sequence ID" value="XM_002482522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCC9"/>
    <dbReference type="FunCoup" id="B8MCC9">
        <property type="interactions" value="1096"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MCC9"/>
    <dbReference type="GeneID" id="8108220"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_123050"/>
    <dbReference type="eggNOG" id="KOG1335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_0_1_1"/>
    <dbReference type="InParanoid" id="B8MCC9"/>
    <dbReference type="OMA" id="CAQLGMK"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="PhylomeDB" id="B8MCC9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042743">
        <property type="term" value="P:hydrogen peroxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006550">
        <property type="term" value="P:L-isoleucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000025">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10 12" id="KW-0274">FAD</keyword>
    <keyword evidence="3 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 12 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 12" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="14">
        <location>
            <begin position="46"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="13">
        <location>
            <begin position="390"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="185"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="222"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="362"/>
            <end position="365"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="83"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED18575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="509" mass="54287" checksum="CCA14D3591ECB381" modified="2009-03-03" version="1">MFRSMLPARSALRIARPQAVPSSAIPAPSLSLFGRRGYASQAEEHDLVIIGGGVAGYVAAIKAGQEGLKTACIEKRGTLGGTCLNVGCIPSKSLLNNSHLYHQILHDTKKRGIEVGDVKLNLQQMLKAKDTSVEGLTKGVEFLLKKNGVDYVKGTGSFLNENEVKVNLTEGGERTLRGKNIIIATGSESTPFPGLEVDEERIVTSTGALSLKEVPKKMVVIGGGIIGLEMASVWSRLGAEVTVVEFLGQIGGPGMDAEISKAAQKILAKQGIKFLTNTKVTKGDTSGSTISISTEAAKGGKEQTLDADVVLVAIGRRPYTEGLGLENIGIEADERGRLIIDQEYRTKLPHIRVIGDVTFGPMLAHKAEEEAVAAIEYITKGHGHVNYAAIPSVMYTHPEVAWVGQSEEELKKAGIKYNKGTFPFSANSRAKTNLETEGLVKFLSDAETDRILGVHILGPNAGEMIAEATLAVEYGASSEDVARTCHAHPTLAEAFKEAAMATYSKAIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCS2</accession>
    <name>B8MCS2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sterigmatocystin biosynthesis regulatory protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_126820</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482966.1">
        <property type="nucleotide sequence ID" value="XM_002482921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCS2"/>
    <dbReference type="STRING" id="441959.B8MCS2"/>
    <dbReference type="GeneID" id="8099109"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_126820"/>
    <dbReference type="eggNOG" id="ENOG502SUW5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_547660_0_0_1"/>
    <dbReference type="InParanoid" id="B8MCS2"/>
    <dbReference type="OrthoDB" id="4226794at2759"/>
    <dbReference type="PhylomeDB" id="B8MCS2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045122">
        <property type="term" value="P:aflatoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013700">
        <property type="entry name" value="AflR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08493">
        <property type="entry name" value="AflR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Aflatoxin regulatory protein" evidence="8">
        <location>
            <begin position="155"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED18974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="498" mass="54628" checksum="9B7CBD8DB9AA446B" modified="2009-03-03" version="1">MSDSIHVPTVSPNSMDLVAEPDTLAPSDDVVQLSPRPPTTEYTDISAAESTTLVDPVTPSTLLLNALNWGFEDFPSPQISLPLSAEMVNAPCSFNDKNLLDNFIGFEKATPLLSSIVLPPSLETDVLQESEASCSVPEPKESHSSVVDTPNPGQTCCFLVRALSLLKQQSSSAPNSCGGCMRPSLENFSRSDNSSLSKIESIIADNEQTIQVISDILTCQCSQDIYLLVIMSIVILKILNYYTAVVRQETSFNGDDRSWVANQPGNSTQYQSEMFQTPPNVFGANGSEYVEDQGRMASQQILSKLHRIQRLINILSERFKTHKENVKRKQEESRASTTVTGPNMFMFLFPSSTLEHIEADLRLHLRALSADAANILCQAWYVLPIVPHVHHLQTYPARSTMSVMHVVPLEKRAQIQGIVGAMFGFATSIGPLICSALTSNMKKIMQLDIFSTLPLIPGIVYLMLALQKGGQTYAVSYYIVTLPEISDCFRAGNNQGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCY3</accession>
    <name>B8MCY3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator (Cti6), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_113350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481501.1">
        <property type="nucleotide sequence ID" value="XM_002481456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCY3"/>
    <dbReference type="FunCoup" id="B8MCY3">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MCY3"/>
    <dbReference type="GeneID" id="8101647"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_113350"/>
    <dbReference type="eggNOG" id="KOG1844">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020879_0_1_1"/>
    <dbReference type="InParanoid" id="B8MCY3"/>
    <dbReference type="OMA" id="RPRYMNP"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="PhylomeDB" id="B8MCY3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061188">
        <property type="term" value="P:negative regulation of rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061186">
        <property type="term" value="P:negative regulation of silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053051">
        <property type="entry name" value="HDAC_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="103"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="196"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="562"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="256"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="427"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="532"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="568"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED17509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="619" mass="68266" checksum="E940E596D0ED0DE0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDC3</accession>
    <name>B8MDC3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucan synthase</fullName>
            <ecNumber evidence="3">2.4.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,3-beta-D-glucan-UDP glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_114570</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21476"/>
            <dbReference type="Rhea" id="RHEA-COMP:11146"/>
            <dbReference type="Rhea" id="RHEA-COMP:14303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.34"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 48 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.34" evidence="3"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481640.1">
        <property type="nucleotide sequence ID" value="XM_002481595.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B8MDC3">
        <property type="interactions" value="598"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MDC3"/>
    <dbReference type="GeneID" id="8109219"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_114570"/>
    <dbReference type="eggNOG" id="KOG0916">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000844_0_1_1"/>
    <dbReference type="InParanoid" id="B8MDC3"/>
    <dbReference type="OMA" id="AWTDFFI"/>
    <dbReference type="OrthoDB" id="1880850at2759"/>
    <dbReference type="PhylomeDB" id="B8MDC3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000148">
        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051278">
        <property type="term" value="P:fungal-type cell wall polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026899">
        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056261">
        <property type="entry name" value="FKS1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF48">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23605">
        <property type="entry name" value="FKS1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01205">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="580"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="608"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="669"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="723"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1398"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1489"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1515"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1604"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1646"/>
            <end position="1670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1682"/>
            <end position="1706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1712"/>
            <end position="1731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1779"/>
            <end position="1805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1839"/>
            <end position="1863"/>
        </location>
    </feature>
    <feature type="domain" description="1,3-beta-glucan synthase component FKS1-like" evidence="13">
        <location>
            <begin position="347"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED17648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1927" mass="220035" checksum="79C96BB61E9E5C07" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B8ME78</accession>
    <name>B8ME78_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein kinase ATG1</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Autophagy-related protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Serine/threonine-protein kinase atg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">TSTA_015890</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer. Forms a ternary complex with ATG13 and ATG17.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483739.1">
        <property type="nucleotide sequence ID" value="XM_002483694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ME78"/>
    <dbReference type="FunCoup" id="B8ME78">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8ME78"/>
    <dbReference type="GeneID" id="8106362"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_015890"/>
    <dbReference type="eggNOG" id="KOG0595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006447_0_0_1"/>
    <dbReference type="InParanoid" id="B8ME78"/>
    <dbReference type="OMA" id="INNVVQW"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="PhylomeDB" id="B8ME78"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120095">
        <property type="term" value="C:vacuole-isolation membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051365">
        <property type="term" value="P:cellular response to potassium ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14009">
        <property type="entry name" value="STKc_ATG1_ULK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000817">
        <property type="entry name" value="Serine/threonine-protein kinase ATG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000399">
        <property type="entry name" value="Serine/threonine-protein kinase atg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048941">
        <property type="entry name" value="ATG1-like_MIT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022708">
        <property type="entry name" value="Atg1-like_tMIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12063">
        <property type="entry name" value="ATG1-like_MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21127">
        <property type="entry name" value="ATG1-like_MIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
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            <position position="56"/>
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        </ligand>
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        <source>
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        </source>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="964" mass="105941" checksum="6CBFBC579829C554" modified="2009-03-03" version="1"> </sequence>
</entry>
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    <accession>B8MEC6</accession>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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                <person name="Fedorova-Abrams N.D."/>
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            <dbReference type="PubMed" id="25676766"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED16553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1082" mass="119875" checksum="B46D34951C23A757" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEU4</accession>
    <name>B8MEU4_TALSN</name>
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        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyrate dehydrogenase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="11" type="ORF">TSTA_020360</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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        </lineage>
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    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <reaction evidence="7">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
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        </reaction>
    </comment>
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        <text evidence="1">Amino-acid degradation; L-valine degradation.</text>
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    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
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    <dbReference type="EMBL" id="EQ962656">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002484166.1"/>
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    <dbReference type="eggNOG" id="KOG0409">
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    <dbReference type="HOGENOM" id="CLU_035117_6_1_1"/>
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    <dbReference type="PhylomeDB" id="B8MEU4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000630">
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="9">
        <location>
            <begin position="34"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="10">
        <location>
            <begin position="210"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED16977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="342" mass="36876" checksum="53B53C9210882DA4" modified="2009-03-03" version="1">MIPARALPLGKSIKSGSHSQRLFSTSLRRDATWGFIGLGRMGYPMAKNLRAKIPASDTLIVHDVNEQAMRQFVDEAKTASTGPVEFTDSARTVAEKSLNIITSLPQPVHVRHVFHSILKPGPLPQLEQERLFIDTSTIDPVTSKEVAYAVQAPNQGRFVDAPMSGGVVAAEAGTLSFMFGASSKTGALVDRVREILALMGKKAWHLGEQGTGVSGKLANNYILAINNIAVAEAMNLGIRWGLDPKTLADMINASTGRCWPSEVNNPVPGVIEKSPASRDYEGGFGIGLMRKDLKLAIDAAQESGAPLELAATARGLYEAVEDIYPGKDFSIVYKYLSDISRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MF03</accession>
    <name>B8MF03_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_008970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483006.1">
        <property type="nucleotide sequence ID" value="XM_002482961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MF03"/>
    <dbReference type="STRING" id="441959.B8MF03"/>
    <dbReference type="GeneID" id="8100758"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_008970"/>
    <dbReference type="eggNOG" id="ENOG502RUBM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_511088_0_0_1"/>
    <dbReference type="InParanoid" id="B8MF03"/>
    <dbReference type="OrthoDB" id="4357294at2759"/>
    <dbReference type="PhylomeDB" id="B8MF03"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED15772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="533" mass="58631" checksum="EAD957BCB9538532" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8MF78</accession>
    <name>B8MF78_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_012840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483411.1">
        <property type="nucleotide sequence ID" value="XM_002483366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MF78"/>
    <dbReference type="STRING" id="441959.B8MF78"/>
    <dbReference type="GeneID" id="8108160"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_012840"/>
    <dbReference type="HOGENOM" id="CLU_1462267_0_0_1"/>
    <dbReference type="InParanoid" id="B8MF78"/>
    <dbReference type="OMA" id="DPENMAF"/>
    <dbReference type="OrthoDB" id="4224437at2759"/>
    <dbReference type="PhylomeDB" id="B8MF78"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED16177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23844" checksum="01D352CF1A70858C" modified="2009-03-03" version="1">MSEPPLRFNLIELESEGTIPVYVNDRFAWQLPKKLLSMRAPKVLEGDATSWKIQNFSPDAFKLLTGWLYSPRGILSGPPAGKPINPYLELARLANRYEIAGLAPLVNKMVQKSFDDPENMAFMGETYNALDPHSPDRASISARFAALVVSKNMDVSTLKPLLKSSDLTRDMLAWIAIYYEHRCEHKELDEIMIWMAGQCQLWLDAVDEAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFT6</accession>
    <name>B8MFT6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_009250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483037.1">
        <property type="nucleotide sequence ID" value="XM_002482992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFT6"/>
    <dbReference type="STRING" id="441959.B8MFT6"/>
    <dbReference type="GeneID" id="8100786"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_009250"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051551_1_0_1"/>
    <dbReference type="InParanoid" id="B8MFT6"/>
    <dbReference type="OrthoDB" id="4526357at2759"/>
    <dbReference type="PhylomeDB" id="B8MFT6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="196" mass="20951" checksum="DB3E4DA2C71C3933" modified="2009-03-03" version="1">MARKGPGTDGPLQTALLESMSAATTRASEGQKIFSPIAAFLNKHRSQTTSLAPHLLRALTTLSDDLALVAQQHFNAYISGILTTSILPTLSSSSSSSLTLNPLPSSPSSSRPPSGLEQSTYATITQYAPVKLTPTTHPKASVKKPMPLVKQPLPNNWLFTGFALCPSSPEALLAFEAQKEIISAFFINCQIERSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MG96</accession>
    <name>B8MG96_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_013220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483450.1">
        <property type="nucleotide sequence ID" value="XM_002483405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MG96"/>
    <dbReference type="FunCoup" id="B8MG96">
        <property type="interactions" value="253"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MG96"/>
    <dbReference type="GeneID" id="8108198"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_013220"/>
    <dbReference type="eggNOG" id="KOG3043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_2_1_1"/>
    <dbReference type="InParanoid" id="B8MG96"/>
    <dbReference type="OMA" id="PGKCCFE"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="PhylomeDB" id="B8MG96"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="247" mass="27507" checksum="F3CD72CA97744377" modified="2009-03-03" version="1">MASNPPGSCCYKGVKHEGQPVGSISTVKDFEVYTSYPADKSTDYAVLLLTDILGHKFQNLQLIADQFASNGYFVFMPDLFHGDPVALNPPEGFDLFKWLSGHPKETVEPIVEASITELREKYKVKKIAAVGYCFGAKYVVRHLHPQQNKIDVGFIAHPSFVEADELKAIGGALAIAAAETDTIFPTEKRHESEVILKDTKLPYQINLYSGVVHGFAVRCDLSDKVAKYAKENAFLQAVQWFETYLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MH01</accession>
    <name>B8MH01_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell wall integrity signaling protein Lsp1/Pil1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_014740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483616.1">
        <property type="nucleotide sequence ID" value="XM_002483571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MH01"/>
    <dbReference type="FunCoup" id="B8MH01">
        <property type="interactions" value="522"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MH01"/>
    <dbReference type="GeneID" id="8107857"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_014740"/>
    <dbReference type="eggNOG" id="ENOG502QQ1T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046464_0_2_1"/>
    <dbReference type="InParanoid" id="B8MH01"/>
    <dbReference type="OMA" id="NRWLGKG"/>
    <dbReference type="OrthoDB" id="5599269at2759"/>
    <dbReference type="PhylomeDB" id="B8MH01"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036286">
        <property type="term" value="C:eisosome filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000005">
        <property type="entry name" value="Sphingolipid long chain base-responsive pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF1">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13805">
        <property type="entry name" value="Pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="273"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED16382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="351" mass="39423" checksum="419EB3B704B844B8" modified="2009-03-03" version="1">MHRTYSMRQSRAPTASQIENPPPPPSSTKSGRLFGRNNFGHAFRKNAAGAFGPDLAKKLSQLVKMEKNVMRSMEQVGRERMEVAQQLSIWGEAGDDDVSDVTDKLGVLIYEIGELEDQFVDRYDQYRLTIKSIRNIEASVQPSRDRKQKITDEIAKLKYKDPNSPRIVVLEQELVRAEAESLVAEAQLSNITREKLKAAFTYQFDALREHCEKIAIIAGYGKHLLELIDDTPVTPGETRQAYDGYEASKAIIQDCEDALTNWVSSTAAVRSNLSTRSRTLSQRRRNNIKRHTEDAEELKDHDSWVPADQHAGYHEDDVSEDGIVEDDGSIAHSGANGEVRGRAEEREPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>B8MI35</accession>
    <name>B8MI35_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_022510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484431.1">
        <property type="nucleotide sequence ID" value="XM_002484386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MI35"/>
    <dbReference type="GeneID" id="8107088"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_022510"/>
    <dbReference type="HOGENOM" id="CLU_2211735_0_0_1"/>
    <dbReference type="InParanoid" id="B8MI35"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED17197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="107" mass="12435" checksum="797BC6221D8F1B20" modified="2009-03-03" version="1">MQACLETWSDRRYKKEKTRLRPEPLALDSRGLEEYCMDRRDINLKLSYQLTQPSHLSSYSILASYLSHQITQTQMARTKVSARRIVKRGSFKTLPGGPRPVSKAFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIH8</accession>
    <name>B8MIH8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytokinesis regulator (Byr4), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_045320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485023.1">
        <property type="nucleotide sequence ID" value="XM_002484978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIH8"/>
    <dbReference type="STRING" id="441959.B8MIH8"/>
    <dbReference type="GeneID" id="8099496"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_045320"/>
    <dbReference type="eggNOG" id="ENOG502QX1K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008906_0_0_1"/>
    <dbReference type="InParanoid" id="B8MIH8"/>
    <dbReference type="OMA" id="DWGEGSL"/>
    <dbReference type="OrthoDB" id="19159at2759"/>
    <dbReference type="PhylomeDB" id="B8MIH8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990334">
        <property type="term" value="C:Bfa1-Bub2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034586">
        <property type="entry name" value="Bfa1/Byr4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35140">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BFA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35140:SF1">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BFA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="915"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="717"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="925"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="991" mass="108290" checksum="EDC8FDC7A82E1120" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJB1</accession>
    <name>B8MJB1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trichothecene 3-O-acetyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_041770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484653.1">
        <property type="nucleotide sequence ID" value="XM_002484608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJB1"/>
    <dbReference type="STRING" id="441959.B8MJB1"/>
    <dbReference type="GeneID" id="8102954"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_041770"/>
    <dbReference type="eggNOG" id="ENOG502SHVS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026450_5_0_1"/>
    <dbReference type="InParanoid" id="B8MJB1"/>
    <dbReference type="OMA" id="AFIWQSV"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="PhylomeDB" id="B8MJB1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF64">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED14700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="297" mass="33583" checksum="A80576A466C811B5" modified="2009-03-03" version="1">MAGQGQVMYLFAKACRHEPFSEEEISIGNIDRRNVVQLLDDHVQLQETAAPDPPRIKNSPSSQRDRAKESQSKKLQSSSNDCTWTYFSFCRSKLASLKSQATATLPRETNGFVSTDDVLTIYSNEWERIKLKTTLSRNVNVRQHLQIPASYPGFVTNTTLHTFALDEVANHLLGYLSSQLRSALSPESLNQRTRELATRIRRDKNSANATIVPKGNPELDVRLSSWAKENCYNLDFGFGLPLAVRRPRFTDGSREGLVYFLPKAPDGEIVVGICLRRDDMERLKKHQDFAKFGTFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJD5</accession>
    <name>B8MJD5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_041990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484677.1">
        <property type="nucleotide sequence ID" value="XM_002484632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJD5"/>
    <dbReference type="STRING" id="441959.B8MJD5"/>
    <dbReference type="GeneID" id="8102976"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_041990"/>
    <dbReference type="HOGENOM" id="CLU_013929_8_1_1"/>
    <dbReference type="InParanoid" id="B8MJD5"/>
    <dbReference type="OrthoDB" id="4207519at2759"/>
    <dbReference type="PhylomeDB" id="B8MJD5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="57"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED14724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="199" mass="22794" checksum="42C3791469E388E5" modified="2009-03-03" version="1">MVKSRTKNDPSYEGRLSLAIDALNNEKITKLRDAARTFDVSLTTLRRRLKGSVPAHNAGITRRKITPTEEAVLRGWVFSLERRGVPPRQHMLHEMANILLAQRDPTKIPEKVGKNWVTTFLKRQPDLKAKFAHRLSYSRALCEDPVVIGGFFEEIKQLKEEYGIADEDIYNFDETGTALAVPYLATRRAAALRREWLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJI1</accession>
    <name>B8MJI1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_046350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485134.1">
        <property type="nucleotide sequence ID" value="XM_002485089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJI1"/>
    <dbReference type="STRING" id="441959.B8MJI1"/>
    <dbReference type="GeneID" id="8099546"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_046350"/>
    <dbReference type="HOGENOM" id="CLU_970366_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJI1"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="287" mass="32052" checksum="C918FC22DF10F754" modified="2009-03-03" version="1">MDPLSLTASIIVVLGLASETSKALRTLYDLRHAPREILELTNEVSELQALLCLVQKATDSAVQNHLSAEDQVLIQRLIETAQDPLKKLEGLIDMCSSKKEMSSGSVEKSSLRLSVSWLKLKNSISNIRKRFLRAHRNIDTALAALNNINRQADYKVILNIHDLVLTQAQASEHGISPASPETVQNLEQKFNGIICDVNEEKTGELFKESILPVPAARNTMTREIAEKKFDSYYSHEDEPGLFENHATIRASIATPEHLYFNFDHAITEDANNKRPSHASSHTIFRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJL1</accession>
    <name>B8MJL1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase, short chain dehydrogenase/reductase family superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_046650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485164.1">
        <property type="nucleotide sequence ID" value="XM_002485119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJL1"/>
    <dbReference type="GeneID" id="8099576"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_046650"/>
    <dbReference type="eggNOG" id="KOG1611">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_1_1"/>
    <dbReference type="InParanoid" id="B8MJL1"/>
    <dbReference type="OMA" id="RMYTTSS"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="PhylomeDB" id="B8MJL1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF2">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY SUPERFAMILY (AFU_ORTHOLOGUE AFUA_3G13450)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED15211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="269" mass="29158" checksum="F0CA4FABF51135AD" modified="2009-03-03" version="1">MSTILIIGATRGLGASLTTYYASLPSTSTIYATTRSNKPPSNFPDHNNKTKIHWLLNVDISKPDVGHNLTAQIIPHNNKKLDIIIVNAGYFGSESFDNPDWEKEVRMYTTSAIGPVFAIQALVKSGLIAEGRNGKGGKVIFISSEAGSITLRHESEGGGNYGHHASKAALNMVGKLLSLDLKEIGIAIGMMHPGFMRTEMTRGVGFDRFWEDGGAVTPDEAAKSLAEFVEKDFDIEKTGTYWAPRGPRDIGTAEPVLGKNLSTPLELPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJP8</accession>
    <name>B8MJP8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_051840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485700.1">
        <property type="nucleotide sequence ID" value="XM_002485655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJP8"/>
    <dbReference type="STRING" id="441959.B8MJP8"/>
    <dbReference type="GeneID" id="8103405"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_051840"/>
    <dbReference type="HOGENOM" id="CLU_1235761_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJP8"/>
    <dbReference type="OMA" id="EQDMMAK"/>
    <dbReference type="OrthoDB" id="4507940at2759"/>
    <dbReference type="PhylomeDB" id="B8MJP8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="42"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED15747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="224" mass="25818" checksum="023A126C90AA5513" modified="2009-03-03" version="1">MRQLQWKRVPWKQEMLTALDAGIEKLKAYYNDTQEIHGTVKKKPCDFWKEMEDKYPTLARVAWDIFSIPATGAGVERLFNSARDICYYQRGSLNSTTIQDLMMFQCISKFNIKVEDDREDINIPLEDRQQKDEAREAELQDIVPDPISDHEESDSEENDGEENNGEEVIQLTEVVEEATTVSNPTTINKKSNALPQPSKRALRKRRIILVEEHTDDEALLGTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJR8</accession>
    <name>B8MJR8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_042100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484688.1">
        <property type="nucleotide sequence ID" value="XM_002484643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJR8"/>
    <dbReference type="STRING" id="441959.B8MJR8"/>
    <dbReference type="GeneID" id="8102987"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_042100"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1082498_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJR8"/>
    <dbReference type="OrthoDB" id="3799035at2759"/>
    <dbReference type="PhylomeDB" id="B8MJR8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF463">
        <property type="entry name" value="REVERSE TRANSCRIPTASE TY1_COPIA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="257" mass="28618" checksum="26075B71BB7B7374" modified="2009-03-03" version="1">MICTRPDLAFALSRLSKFVQKPGIKYATALKRVLSSTYDAEYIGLATASYEVIWLQKLILAILPQYAEHTMPSNTIHCDNQGAIVTVNQPSHSPSTRSKHINIYFHVIREAIANGLIRLEYIRITEMTADILTKALPKELHERHWEDTSRSDAFGEIPDEWECQRATPVDLPPARINYAPRVITLTPTTGPRDDLLAELRARTGRPCGHGNRQNPGAGQGGDGPDCGTDAGFDVGRARKQACRHKSQLFIESFQTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJX2</accession>
    <name>B8MJX2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GNAT family acetyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_042640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484742.1">
        <property type="nucleotide sequence ID" value="XM_002484697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJX2"/>
    <dbReference type="STRING" id="441959.B8MJX2"/>
    <dbReference type="GeneID" id="8103356"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_042640"/>
    <dbReference type="eggNOG" id="ENOG502SU03">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096760_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJX2"/>
    <dbReference type="OMA" id="FREVPWN"/>
    <dbReference type="OrthoDB" id="2744543at2759"/>
    <dbReference type="PhylomeDB" id="B8MJX2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43800">
        <property type="entry name" value="PEPTIDYL-LYSINE N-ACETYLTRANSFERASE YJAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43800:SF1">
        <property type="entry name" value="PEPTIDYL-LYSINE N-ACETYLTRANSFERASE YJAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED14789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="212" mass="24073" checksum="578F64DAD87DBD2A" modified="2009-03-03" version="1">MEGTRISTASFKQIGKDIIIRLGVAADIPYLPAIEESASEIFKSIPDLEFIADDPPLSIDTLHSYLSSSHLWVATVEDESGSEIPVAFLAAKSINPARSDEDNQEIANNIQSPRHIYIAECSVHLSFQRRGIAGRLLNTVAEYARKQGFGWLTLITFLDVPWNGKFYQKHGFEEIEAETMGDEYVEILKEELDQWKNWKSKRWRRGVMARKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MK03</accession>
    <name>B8MK03_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial ATP synthase epsilon chain domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_042920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ATPase epsilon family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484773.1">
        <property type="nucleotide sequence ID" value="XM_002484728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MK03"/>
    <dbReference type="FunCoup" id="B8MK03">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MK03"/>
    <dbReference type="GeneID" id="8104769"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_042920"/>
    <dbReference type="eggNOG" id="KOG3495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_187039_0_0_1"/>
    <dbReference type="InParanoid" id="B8MK03"/>
    <dbReference type="OMA" id="NKYTQIA"/>
    <dbReference type="OrthoDB" id="269124at2759"/>
    <dbReference type="PhylomeDB" id="B8MK03"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12153">
        <property type="entry name" value="F1-ATPase_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.20:FF:000003">
        <property type="entry name" value="Mitochondrial ATP synthase epsilon chain domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.20">
        <property type="entry name" value="ATP synthase, F1 complex, epsilon subunit superfamily, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006721">
        <property type="entry name" value="ATP_synth_F1_esu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036742">
        <property type="entry name" value="ATP_synth_F1_esu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12448">
        <property type="entry name" value="ATP SYNTHASE EPSILON CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12448:SF0">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT EPSILON, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04627">
        <property type="entry name" value="ATP-synt_Eps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48690">
        <property type="entry name" value="Epsilon subunit of mitochondrial F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="73" mass="8122" checksum="89230DB5B2136A73" modified="2009-03-03" version="1">MVAAWKAAGLTYNKYLAVAARAVRRSLKDSQRLNAERRGQSDLKFAKWENGKQGEVKQLVDANAESQATQAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKM7</accession>
    <name>B8MKM7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_048250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485335.1">
        <property type="nucleotide sequence ID" value="XM_002485290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKM7"/>
    <dbReference type="STRING" id="441959.B8MKM7"/>
    <dbReference type="GeneID" id="8107007"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_048250"/>
    <dbReference type="eggNOG" id="ENOG502RS52">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_973784_0_0_1"/>
    <dbReference type="InParanoid" id="B8MKM7"/>
    <dbReference type="OMA" id="HIGHCIF"/>
    <dbReference type="OrthoDB" id="3501153at2759"/>
    <dbReference type="PhylomeDB" id="B8MKM7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053008">
        <property type="entry name" value="Phomopsin_biosynth_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="286" mass="32958" checksum="1CB6DDA37B28E465" modified="2009-03-03" version="1">MAPQFSTQDEENAMSREPFLKASMQEDSSKNAENLLRPTRQYFLGLLGVTLLIAVTILLSQLFLRNREAAYLLHCGHSVEEARALGCEFDILSYTWTPKECYDKETADEFRQWLTRPERFPRPWPFFADKNRTEWIPSEEALSKRAHMMTYAPQEEHIGHCIFMMRRLHRINDGSAKMNSRFGKYSHTEHCTNETLDAVSSRIIRDEDANLGPKNVLIHISAVGESSFVVKYMCMCVFVCFYLTAVVRDSHVSHRFLLGHRPPRETLWRISVAAVVLQEGPLLSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKN1</accession>
    <name>B8MKN1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_048290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485339.1">
        <property type="nucleotide sequence ID" value="XM_002485294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKN1"/>
    <dbReference type="STRING" id="441959.B8MKN1"/>
    <dbReference type="GeneID" id="8107011"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_048290"/>
    <dbReference type="eggNOG" id="ENOG502SGDH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149439_2_0_1"/>
    <dbReference type="InParanoid" id="B8MKN1"/>
    <dbReference type="OrthoDB" id="3358869at2759"/>
    <dbReference type="PhylomeDB" id="B8MKN1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042332">
        <property type="entry name" value="Hsk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013183">
        <property type="entry name" value="Hsk3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289">
        <property type="entry name" value="DASH COMPLEX SUBUNIT HSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT HSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08227">
        <property type="entry name" value="DASH_Hsk3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="95" mass="10118" checksum="3FE3EE4C9A188195" modified="2009-03-03" version="1">MNNNANMSTTKSRQYAHLHSQLAQLNAHLADTENLAGDMRFLGGYVGGLFMGAAKVLGEEGVQQTQNQSQGQGQGQGQGQGQGQGLKREEGDKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8ML77</accession>
    <name>B8ML77_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NmrA-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_044580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484945.1">
        <property type="nucleotide sequence ID" value="XM_002484900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ML77"/>
    <dbReference type="STRING" id="441959.B8ML77"/>
    <dbReference type="GeneID" id="8104134"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_044580"/>
    <dbReference type="eggNOG" id="ENOG502SAD9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044876_3_3_1"/>
    <dbReference type="InParanoid" id="B8ML77"/>
    <dbReference type="OMA" id="SHEEHIS"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="PhylomeDB" id="B8ML77"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED14992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="301" mass="31939" checksum="1D7F4564B1C2339C" modified="2009-03-03" version="1">MASLKNIAIIGASGSIGKIILDALIKAPQFNVTVLSRASSETTFPTGVSVRKSDFSDSDLVSALKGQDAVISVVGPTGFAEQKKFIDAAISAGVKRFLPSEYSANTLSPAVLQLLPLFNQKKETLEYLKTKESSGFSWTAIYTALLFDWGLGNGFLGFDVSAHTATIWDDGSKVFTLTNADQLGRAVVSVLEHPEKTANKNLYVASAETSQKEILAALEKATGSKFAVTNTTTEKELSEAGEKLSKGDFSGALILVRATSFGSTPGIRANYAKEEELANDLLGLKLESVDETVARVVKGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLJ9</accession>
    <name>B8MLJ9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_049700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485485.1">
        <property type="nucleotide sequence ID" value="XM_002485440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLJ9"/>
    <dbReference type="GeneID" id="8101085"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_049700"/>
    <dbReference type="HOGENOM" id="CLU_540907_0_0_1"/>
    <dbReference type="InParanoid" id="B8MLJ9"/>
    <dbReference type="OrthoDB" id="4222100at2759"/>
    <dbReference type="PhylomeDB" id="B8MLJ9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="510" mass="57906" checksum="E0A4462DBC5FFC0F" modified="2009-03-03" version="1">MNECQREMENLDITGEHDGTNSDSDTTIGPSPRRSSARSNPFDMELPDDFAPRSLEWFMNPRPDPKKPLSMFWTDPVGYYAAPTASRSSPENEEQSKQDDGKLGTMGSLDQWFLPRKRDKTEIPKWTVGAPLFELPFRRVSITASDISRFQIARPPTPPRKRSPDTMSNKPLPPLPRARRFVSEGHAPLLTHPRSPGVPAEFTLSRWSDSSESDTTQEVPATTESVDTHEAPQELEQATSTMNGASTNGEPAGGNILANGPHLLVRIHHYLDRRMTAINQMETTLSNPHIPQALRKRFIAWSQQLIDLDYPFLTNPPTRHLEQVKIYEKDAHRVVDWAIEVGTMVNVIQDQLNQFMDAADLVAGELREMTARLDMDNGSLLPAEELYHKMTDIVRRKCRSPHLHEALLLRSFLNLYDNLMYNPFQIIKDQVVVVHDEYPHDPVTIPLNIETPLSLLKRVLDAVYVSHGEYTELTRRIRQEFFVPIEERIPGVASRTEGYLNNVIGPSNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLS3</accession>
    <name>B8MLS3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_099000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485883.1">
        <property type="nucleotide sequence ID" value="XM_002485838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLS3"/>
    <dbReference type="STRING" id="441959.B8MLS3"/>
    <dbReference type="GeneID" id="8103978"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_099000"/>
    <dbReference type="eggNOG" id="KOG0159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022195_0_1_1"/>
    <dbReference type="InParanoid" id="B8MLS3"/>
    <dbReference type="OMA" id="AKIGQQI"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="PhylomeDB" id="B8MLS3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF4">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED13645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="523" mass="60139" checksum="8C81D25454A70333" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLT8</accession>
    <name>B8MLT8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Monoxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_100500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486043.1">
        <property type="nucleotide sequence ID" value="XM_002485998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLT8"/>
    <dbReference type="STRING" id="441959.B8MLT8"/>
    <dbReference type="GeneID" id="8097934"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_100500"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_912699_0_0_1"/>
    <dbReference type="InParanoid" id="B8MLT8"/>
    <dbReference type="OMA" id="IWEMPPA"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="PhylomeDB" id="B8MLT8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED13805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="305" mass="34048" checksum="28CF81DD496BDEE1" modified="2009-03-03" version="1">MCQGELSRGATKFSELGAGAVLSPNSQRAMQLIDPRIFEGFQRRAAFGVDPPDENGIFPWMTMTKGQSLDIGEPVMQWNHEIRGSTIHRAHFLDELAELIEPNHAHFGKSVTKISENGDDNPIILNFKDGTTAEADLVIELVPDHGTTLGWSIWEMPPAPTYYKGRVAIMGDAAHASTSYQDAGAGQTIEDSLVMERLLGKYFDPEREKVHALDTVETTHLIFQAFGTVRRHRSQKFQTTSSETGRILTGAEPGVSMKAADMSKRMDGRQDWMWNYDQEMQVKDAMLIFEEVEWSRARNAANSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMB8</accession>
    <name>B8MMB8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="4">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_099250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="4"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485910.1">
        <property type="nucleotide sequence ID" value="XM_002485865.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485911.1">
        <property type="nucleotide sequence ID" value="XM_002485866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMB8"/>
    <dbReference type="STRING" id="441959.B8MMB8"/>
    <dbReference type="GeneID" id="8104003"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_099250"/>
    <dbReference type="eggNOG" id="ENOG502RYJ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031468_2_0_1"/>
    <dbReference type="InParanoid" id="B8MMB8"/>
    <dbReference type="OMA" id="GLCFICV"/>
    <dbReference type="OrthoDB" id="3609at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000609">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF40">
        <property type="entry name" value="REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14497)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="6">
        <location>
            <begin position="10"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="7">
        <location>
            <begin position="197"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED13672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="327" mass="35695" checksum="A54B75B5F9EA5856" modified="2009-03-03" version="1">MASGDKIDVLLYGLGAIGSFYAFILSRNPNVRLSVVARSNYDAVKSNGLIVDSQNHGKHTVIPEKVLKTPAEAGQTYDYIVCAHKAIDQDAAVKAIAPTVDENKTTIVIIQNGVGNEEPFRNQWPKATIITCVTWTGATQTFPGYVNHTKSEDMQIGLFPSSLSPSSLTEQARLSTFSTLLTKGGTKFAVLEDMPVQRWEKVVWNAAWNSLTSATLLDTHSWLASSPEAMPMTKRLMTEVIDVGRACGVTTLQYSLIDRLIEKILGMPPIGSSMRTDTVAGRPLEVDVILGYPYKKSKELGLSTPTLDAIYAVVTGVDYRLRNGVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMJ5</accession>
    <name>B8MMJ5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1993 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_099970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485987.1">
        <property type="nucleotide sequence ID" value="XM_002485942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMJ5"/>
    <dbReference type="STRING" id="441959.B8MMJ5"/>
    <dbReference type="GeneID" id="8105440"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_099970"/>
    <dbReference type="eggNOG" id="ENOG502SNKC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090929_1_0_1"/>
    <dbReference type="InParanoid" id="B8MMJ5"/>
    <dbReference type="OMA" id="AYQVQSC"/>
    <dbReference type="OrthoDB" id="3724345at2759"/>
    <dbReference type="PhylomeDB" id="B8MMJ5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="entry name" value="dinb family like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018531">
        <property type="entry name" value="DUF1993"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922">
        <property type="entry name" value="BLL2446 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922:SF1">
        <property type="entry name" value="DUF1993 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09351">
        <property type="entry name" value="DUF1993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="DinB/YfiT-like putative metalloenzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED13749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19849" checksum="78931B3FCF05198B" modified="2009-03-03" version="1">MPGLYKQTVPVFIHYLINLSHLLTKGAQFCEQKEGMTAASMLSFRLIEDMRGLAYQVQSCSNTAKFTIERLGPHDVPTLEDTETTFDELQERIKRTIEILETAKPEAMDAMEDKEVIMETKMGNFRFATGQEYVSNYAIPNFHFHLTTAYCIMRHLGVPLGAFDYLKDVFHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMV8</accession>
    <name>B8MMV8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proteasome regulatory particle subunit (RpnE), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_101010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486099.1">
        <property type="nucleotide sequence ID" value="XM_002486054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMV8"/>
    <dbReference type="FunCoup" id="B8MMV8">
        <property type="interactions" value="1212"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MMV8"/>
    <dbReference type="GeneID" id="8101789"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_101010"/>
    <dbReference type="eggNOG" id="KOG1498">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033860_2_0_1"/>
    <dbReference type="InParanoid" id="B8MMV8"/>
    <dbReference type="OMA" id="AENEMFK"/>
    <dbReference type="OrthoDB" id="268763at2759"/>
    <dbReference type="PhylomeDB" id="B8MMV8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000070">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040896">
        <property type="entry name" value="RPN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18098">
        <property type="entry name" value="RPN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="266"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED13861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="487" mass="56647" checksum="A6B028349CD3DA2A" modified="2009-03-03" version="1">MSGELLKPEKDFSKDADKIIPEAQELAKSNVQAAIDKLSLLEKHARQASDLATTSRVIVTIVLISKESGDWSLLNDQVLLLSKKHGQLKQATTKMVQKVMEFLEDTPDVETKLSVIETLRTVTEGKIFVEVERARITRYLSHIKKSQGDLNSATDILCELQVETFGSMTRREKTEFILEQVALCIEKGDWTQAAILSRKINKRYFARKPKKTPEQLEKEQKEYEERVKTRASDEPMPEKDESVEDLKLRYYEQQIILSKHDHNYLDTCKHYRDVLDTESVEEEPERLRAVLARIVYYVVLAPYDNEQSDLLHRIQQDSRLSQVPTEARLLKLFTVHELMRWPEIAETFGPHLTSTDVFDKEQNPNDPDAHTRWQDLRKRVIEHNVRVIAKYYTRIQTSRLTQLLDLNEEETEKYISDLVTSKTIYAKIDRPARVINFAKPRDADDVLNEWSSNMRSLLGLLERIDHLITKEEMMARIQPTKSEKVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNP9</accession>
    <name>B8MNP9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chitin synthase activator (Chs3), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_103590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486376.1">
        <property type="nucleotide sequence ID" value="XM_002486331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNP9"/>
    <dbReference type="STRING" id="441959.B8MNP9"/>
    <dbReference type="GeneID" id="8103062"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_103590"/>
    <dbReference type="eggNOG" id="KOG1550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008036_1_0_1"/>
    <dbReference type="InParanoid" id="B8MNP9"/>
    <dbReference type="OMA" id="DHIRYAA"/>
    <dbReference type="OrthoDB" id="4095816at2759"/>
    <dbReference type="PhylomeDB" id="B8MNP9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF2">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="506"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="692"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="718"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED14138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="771" mass="83773" checksum="CBBE15B23E76DF43" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNU8</accession>
    <name>B8MNU8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_104070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486425.1">
        <property type="nucleotide sequence ID" value="XM_002486380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNU8"/>
    <dbReference type="GeneID" id="8103178"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_104070"/>
    <dbReference type="HOGENOM" id="CLU_000680_26_0_1"/>
    <dbReference type="InParanoid" id="B8MNU8"/>
    <dbReference type="OMA" id="IPGHANT"/>
    <dbReference type="OrthoDB" id="4357294at2759"/>
    <dbReference type="PhylomeDB" id="B8MNU8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31365" checksum="EB2CA4199DE45724" modified="2009-03-03" version="1">MALDSDDKLRELQPLRAKSNGPHESQVFDAEAEAALAGAQAAIAYPTAQFATNLWICLDNLEVAIRLLSPSTGSSQEIFESFRTLAAAWPLRKRLPHTKSGSIQIRWVPGHAKIPENEAADLAAKEGAASIPPAPHKSSYASLKRYAKTQSLSAAQSQWEKVAPQSYQDLEITTSPKRPGELQLNRLDLGHVIAARTGHGDFADYHERFNHDDAYLLCRCGARKAPLHFFFCHIAKRRAPRPPGPPSEVISFLLGTAKGAQKLATWLAETHFFEDICPRQPLLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8MP16</accession>
    <name>B8MP16_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_104690</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="2"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486493.1">
        <property type="nucleotide sequence ID" value="XM_002486448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MP16"/>
    <dbReference type="FunCoup" id="B8MP16">
        <property type="interactions" value="1298"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MP16"/>
    <dbReference type="GeneID" id="8098690"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_104690"/>
    <dbReference type="eggNOG" id="KOG1148">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_2_3_1"/>
    <dbReference type="InParanoid" id="B8MP16"/>
    <dbReference type="OMA" id="TWCIYPM"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="PhylomeDB" id="B8MP16"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000007">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000015">
        <property type="entry name" value="Glutaminyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000183">
        <property type="entry name" value="Glutaminyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="11">
        <location>
            <begin position="95"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="12">
        <location>
            <begin position="407"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="13">
        <location>
            <begin position="519"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="16"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED14255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="631" mass="71624" checksum="BF2DD863A4753B88" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPR9</accession>
    <name>B8MPR9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_052280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486816.1">
        <property type="nucleotide sequence ID" value="XM_002486771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPR9"/>
    <dbReference type="STRING" id="441959.B8MPR9"/>
    <dbReference type="GeneID" id="8106818"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_052280"/>
    <dbReference type="eggNOG" id="ENOG502T0MP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_521928_0_0_1"/>
    <dbReference type="InParanoid" id="B8MPR9"/>
    <dbReference type="OrthoDB" id="4526527at2759"/>
    <dbReference type="PhylomeDB" id="B8MPR9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED12705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="522" mass="58508" checksum="A3A7A00708B4B645" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPX7</accession>
    <name>B8MPX7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_053800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486977.1">
        <property type="nucleotide sequence ID" value="XM_002486932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPX7"/>
    <dbReference type="STRING" id="441959.B8MPX7"/>
    <dbReference type="GeneID" id="8098331"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_053800"/>
    <dbReference type="eggNOG" id="ENOG502S411">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101141_0_2_1"/>
    <dbReference type="InParanoid" id="B8MPX7"/>
    <dbReference type="OMA" id="DNDAYGH"/>
    <dbReference type="OrthoDB" id="2420454at2759"/>
    <dbReference type="PhylomeDB" id="B8MPX7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000104">
        <property type="entry name" value="Thioesterase family protein (AFU_orthologue AFUA_2G16350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050563">
        <property type="entry name" value="4-hydroxybenzoyl-CoA_TE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793">
        <property type="entry name" value="4-HYDROXYBENZOYL-COA THIOESTERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793:SF27">
        <property type="entry name" value="NOVEL THIOESTERASE SUPERFAMILY DOMAIN AND SAPOSIN A-TYPE DOMAIN CONTAINING PROTEIN (0610012H03RIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="31"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED12866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="164" mass="18626" checksum="C8E36FA080DEF948" modified="2009-03-03" version="1">MSDKSSKKLRTRADYPFHLEYRTRWSDNDMYGHLNNSIYAFLFDSIINHYLINHCGIDPAQQRPKQTQKHNQIGLVVSSYCDYFASVAYPDVLELGLRVVKLGSSSVVYEVGVFRAGEELVKVVGGFTHVFVERETMKPRSSGGMDGSVREGLERLYAADNPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQ50</accession>
    <name>B8MQ50_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSTA_055760</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487187.1">
        <property type="nucleotide sequence ID" value="XM_002487142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQ50"/>
    <dbReference type="FunCoup" id="B8MQ50">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MQ50"/>
    <dbReference type="GeneID" id="8102269"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_055760"/>
    <dbReference type="eggNOG" id="KOG0036">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_2_2_1"/>
    <dbReference type="InParanoid" id="B8MQ50"/>
    <dbReference type="OMA" id="VISYAEW"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="PhylomeDB" id="B8MQ50"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000016">
        <property type="entry name" value="Solute carrier family 25 member 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="74"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="110"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="275"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="396"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="499"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EED13076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="592" mass="65741" checksum="B8AE24EE0A3577F0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8MR47</accession>
    <name>B8MR47_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_054540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487053.1">
        <property type="nucleotide sequence ID" value="XM_002487008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MR47"/>
    <dbReference type="GeneID" id="8100392"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_054540"/>
    <dbReference type="eggNOG" id="ENOG502RZZG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026180_1_0_1"/>
    <dbReference type="InParanoid" id="B8MR47"/>
    <dbReference type="OMA" id="HIAGCTQ"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="PhylomeDB" id="B8MR47"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED12942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="55364" checksum="1DCFD8DF4FA8FDAA" modified="2009-03-03" version="1">MASPPWYRIPGSHKTGRTAKLTISLLFLPLDTFIFFVAAFLNHFHFFHHQQRHNRQLLLQNPRFYPKTILITGINTPHGLKLARQFHYGGHRVIGTDVGLSYFRSGGSMSNTIFAYYSLSGSKSQYVSNLTDIIHREKVDLWIPYSSDITPVEDAMAKGTIESRTSCKCLHLNVDYATLFGQHDAFLQHAEERGLPVVEKHTVHSRDSVHRILNRSPNKAYLIHKMSKGSLRDAVALPKSTPSHTYAQVSIIAISKDNPWVLKQRARQGNYWADLVLVRGRVKAIKIRSSRPQKDSRIEPGLYEIIRRLMDNFAEKAGPQISGHLSIKVMVDEEFAPNSVCYTVYIGGCRQGSSAVSALLDDPPSNLYTSYLEMLSPEANESVDSSIEPQAYNKSGRPQKESNYSAALNRIHIPISPVVYAAGRLWEQTQQLQHSALSYVPFGHRLQKYTPLEGSGFSVFDPLPWWWHYHVSQPVNCMLSLFDSDVETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRZ9</accession>
    <name>B8MRZ9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell wall mannoprotein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_059220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cell wall mannoprotein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487546.1">
        <property type="nucleotide sequence ID" value="XM_002487501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRZ9"/>
    <dbReference type="STRING" id="441959.B8MRZ9"/>
    <dbReference type="GeneID" id="8107392"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_059220"/>
    <dbReference type="eggNOG" id="KOG1216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083917_0_0_1"/>
    <dbReference type="InParanoid" id="B8MRZ9"/>
    <dbReference type="OMA" id="HSHEMTA"/>
    <dbReference type="OrthoDB" id="2422134at2759"/>
    <dbReference type="PhylomeDB" id="B8MRZ9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.140:FF:000001">
        <property type="entry name" value="Cell wall serine-threonine-rich galactomannoprotein Mp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021054">
        <property type="entry name" value="Cell_wall_mannoprotein_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123:SF6">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12296">
        <property type="entry name" value="HsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002875481" description="Cell wall mannoprotein 1" evidence="9">
        <location>
            <begin position="19"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="233"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED13435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="294" mass="28262" checksum="5B38433EB3B63746" modified="2009-03-03" version="1">MKFTTSIIALGLSAQVLANPTVVDRRASRVQRDVAAFESVISDVDTAVKKFDSDVKSYSSGDPSSLLGDSQSIITITNSGVSSLQSQSTLSNTDAVALTTPVQGLSSDVQAAIKDLISKKDALVSAGAGGKIESGLQDQYTAAKSLADLISSKVPPALAGVASDLSSGITDAIQSGIDAFKGTGSTATASASGSSTSSAAGTTSTGAATTTAAGTTAATTAATTAATTATVGSSPAVSTATTAPGSGAATSSGVLPGHSSTSTGVTPKYTGAASANKASGAVGLAAALLAVFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8MS52</accession>
    <name>B8MS52_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_004950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488111.1">
        <property type="nucleotide sequence ID" value="XM_002488066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MS52"/>
    <dbReference type="STRING" id="441959.B8MS52"/>
    <dbReference type="GeneID" id="8104479"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_004950"/>
    <dbReference type="eggNOG" id="ENOG502RN4X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_700152_0_0_1"/>
    <dbReference type="InParanoid" id="B8MS52"/>
    <dbReference type="OMA" id="CQTTICQ"/>
    <dbReference type="OrthoDB" id="3766406at2759"/>
    <dbReference type="PhylomeDB" id="B8MS52"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="48328" checksum="FA5F7468F4687514" modified="2009-03-03" version="1">MAFISIRQLRYWLACIMGGRSFSFFARLKVSKAIKENPVKETTVKEREVSPERRLENNPPQEPKCFIMDLPTELLVLISAHLDPLSEACLALTCKRLLLVSGRSFLSESLRFQKDFAPLFHHYRASQTFSGERWKLIERLEDGRWLACSKCLKLHLRTAFPARELRSSPTARVCSLGESAGVVDLCPCIKMTFQDKVNLIKHLKDREVLTKMPSAIFGSRGYDERYLWHSCTVAYESTEFKIDIYPELNDAEQLIIRTEYRMTTVPHTLGKQQHITTRLGCAHRSIDLWLSSVCQALYCHRHDTFCRACRRISTCGTCGTVLKCPQRRAHLSADNDKATYYFWTLRCLGNSTQMPDGEFAAQRMHPISPHISIRNCPWTLWMHPPPIHAPSLDSDILQPALEDNSVRFANQMYSSLQLGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSA8</accession>
    <name>B8MSA8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS monocarboxylate transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_003040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487895.1">
        <property type="nucleotide sequence ID" value="XM_002487850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSA8"/>
    <dbReference type="GeneID" id="8098000"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_003040"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="InParanoid" id="B8MSA8"/>
    <dbReference type="OMA" id="WVLASHQ"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="PhylomeDB" id="B8MSA8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="55"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED12241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="492" mass="52923" checksum="8A70F042B8C4452E" modified="2009-03-03" version="1">MASILEMQPYNNTEHDSPAISLSRIQTLDREQQEGSSQEDMVPVISSQEPISNSKAIIIVIASFIIVFTCCGINFAFGIYQALYETLSHEPNTPFTGASPAIIDLIGTTAVSVMTIGGPLAVGWAKRFSPRKVTLSGAAIFTLAHILASFGTKLWHFELTQGLLLGVGTCLAYMTSVTVAPTWFSARRGLAMGIILSGTGVGGLVWAPALKACIDAMGYRNALRLTGAVSFVLNTGAGAAMTWEPSRKAQIEVELSYETARNPRNIFAVPLVDLRLVKTRKFIAQALGGIFQGAAYYIPVFFFATYASTLGYSDTAGANFIALSNACNAIGKVVIGYAADRYGRLNVLLLTTIISALSALVFWIPSTLLPFAHQEASRGLFITFTIFYGIFASAYVALFPTSLVELFGPQNFASVNGFLYMLRGLATMVGTPVSGLLIRGSTAAAPVMTPKMYEGMSILVTMLLFATAFSVVWVRVEAMVGPDGRAHWKWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSV2</accession>
    <name>B8MSV2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pogo transposable element, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_000690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED11995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487649.1">
        <property type="nucleotide sequence ID" value="XM_002487604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSV2"/>
    <dbReference type="GeneID" id="8108692"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_000690"/>
    <dbReference type="eggNOG" id="KOG3105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_4_2_1"/>
    <dbReference type="InParanoid" id="B8MSV2"/>
    <dbReference type="OMA" id="ATTHNGW"/>
    <dbReference type="OrthoDB" id="4207519at2759"/>
    <dbReference type="PhylomeDB" id="B8MSV2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="60"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED11995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="386" mass="44360" checksum="353054F4B5FB342D" modified="2009-03-03" version="1">MPPIRKKDPLKSAQTEGKIQLAISDLKNGRISNIREATRIYDIPCTTLRDRLKGIEYKGEKRANHDKLTQSEEDSLVKWVPDLDRRGLPPRHSLVREMVNYLLLQHGKPQVGKNWVTNLIKRRPEIDSKFARKYNYERAKCEDPKIIQEHFDRVRDAISKYGILPEDIYNFDETGFAMGLCATAKVITGSDRYARPKLLQPGNREWVTAIEATNSTGWAIPSYIIFKVKKNVRLGWIDDLPSDWMINISENGWTTDQIGLEWLRTHFIPYCGRSMGSYRMLILDGHGSHLTAEFDRTCTENNIIPICMPPHSSHLLQPLDVGCIAVLKRHYGQVVEQRMRDGFNHIDKLDFLMAFPEARTVAYKARTIQNSFAATGLVPFNPDRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTN0</accession>
    <name>B8MTN0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_004800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488090.1">
        <property type="nucleotide sequence ID" value="XM_002488045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTN0"/>
    <dbReference type="FunCoup" id="B8MTN0">
        <property type="interactions" value="1120"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MTN0"/>
    <dbReference type="MEROPS" id="T01.976"/>
    <dbReference type="GeneID" id="8104464"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_004800"/>
    <dbReference type="eggNOG" id="KOG0863">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_8_0_1"/>
    <dbReference type="InParanoid" id="B8MTN0"/>
    <dbReference type="OMA" id="NTQVYGK"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="PhylomeDB" id="B8MTN0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03749">
        <property type="entry name" value="proteasome_alpha_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000016">
        <property type="entry name" value="Proteasome subunit alpha type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035144">
        <property type="entry name" value="Proteasome_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED12436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="262" mass="28547" checksum="24696FDDD52DD027" modified="2009-03-03" version="1">MFRNNYDNDSVTFSPQGRIFQVEYAQEAVKQGSVVVGLVSKTHAVLVGLKRNAEELSSYQKKVIEIDTHMGIAIAGLSSDARVLSNFMKQQSLGSRMTYGRAIPLDRIVTQIGDRAQTNTQHYGKRPYGVGLLVAGVDDAGPHLFEFQPSGMTQEMLACAIGARSQMARTYLERNLAEFADCSREELISHGLKALRETLSQDKELTIDNTTVGVVGLVPKESATPSGTKLEKFKLYDGQDIGALLEALDGAAAEGEMEVDTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTV0</accession>
    <name>B8MTV0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Formate dehydrogenase</fullName>
            <shortName evidence="6">FDH</shortName>
            <ecNumber evidence="2 6">1.17.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NAD-dependent formate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_005300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>formate + NAD(+) = CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:15985"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.9" evidence="2 6"/>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488147.1">
        <property type="nucleotide sequence ID" value="XM_002488102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTV0"/>
    <dbReference type="FunCoup" id="B8MTV0">
        <property type="interactions" value="451"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MTV0"/>
    <dbReference type="GeneID" id="8105504"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_005300"/>
    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_0_0_1"/>
    <dbReference type="InParanoid" id="B8MTV0"/>
    <dbReference type="OMA" id="HYTDRHR"/>
    <dbReference type="OrthoDB" id="418179at2759"/>
    <dbReference type="PhylomeDB" id="B8MTV0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042183">
        <property type="term" value="P:formate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="FDH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Formate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Formate_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033689">
        <property type="entry name" value="FDH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005750">
        <property type="entry name" value="PRK07574.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF9">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="8">
        <location>
            <begin position="34"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="9">
        <location>
            <begin position="130"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="175"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="231"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="312"/>
            <end position="315"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="6">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="6">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED12493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="363" mass="40027" checksum="A967CA19C903CCE1" modified="2009-03-03" version="1">MGKVLMVLYDGGEHAKDQPGLLGTTENELGIRKWLEDQGHTLVTTSDKEGPDSVFEKELVDAEVIITTPFHPGYLTAERLAKAKNLKLAVTAGIGSDHVDLDAANKTNGGITVAEVTGSNVVSVAEHVVMTILTLVRNFVPAHDQIRNGDWNVAAVAKNEFDLENKVVGTVAVGRIGERVLRRLKPFDCKELLYYDYQPLKPEVEKEIGCRRVDTLEELVSQCDVVTINCPLHEKTKGLFNKELISKMKKGSWLINTARGAIVVKEDVAEAVKSGHLRGYGGDVWFPQPAPKDHPLRYVEGPWGGGNAMVPHMSGTSIDAQIRYAQGTKNILESYFSGRHDYRPEDLIVHKGDYATKAYGQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8MU71</accession>
    <name>B8MU71_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_111040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002488638.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MU71"/>
    <dbReference type="GeneID" id="8110133"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_111040"/>
    <dbReference type="eggNOG" id="KOG2029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003781_1_0_1"/>
    <dbReference type="InParanoid" id="B8MU71"/>
    <dbReference type="OMA" id="ARICNIH"/>
    <dbReference type="OrthoDB" id="4224977at2759"/>
    <dbReference type="PhylomeDB" id="B8MU71"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
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        <property type="entry name" value="Arm_rpt_dom"/>
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        <property type="entry name" value="Cohesin_HEAT"/>
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        <property type="entry name" value="DUF7068"/>
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        <property type="entry name" value="NACHT_NTPase"/>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23948">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cohesin_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF7068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="1">
        <location>
            <begin position="526"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1822" mass="208276" checksum="DAB606EDAF26A3FD" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8MU85</accession>
    <name>B8MU85_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_107800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488345.1">
        <property type="nucleotide sequence ID" value="XM_002488300.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MU85"/>
    <dbReference type="GeneID" id="8106844"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_107800"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_236639_0_0_1"/>
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    <dbReference type="OrthoDB" id="4258323at2759"/>
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    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877772" description="Integrase catalytic domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="1861"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="974"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1255"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1284"/>
            <end position="1296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED11589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1861" mass="208998" checksum="C969929FC8BF2F85" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUE5</accession>
    <name>B8MUE5_TALSN</name>
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        <recommendedName>
            <fullName evidence="6">Kelch repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_109640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002488495.1"/>
    </dbReference>
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    <dbReference type="STRING" id="441959.B8MUE5"/>
    <dbReference type="GeneID" id="8107196"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109640"/>
    <dbReference type="eggNOG" id="ENOG502SIX7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012508_1_2_1"/>
    <dbReference type="InParanoid" id="B8MUE5"/>
    <dbReference type="OMA" id="NIFQWIR"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="PhylomeDB" id="B8MUE5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228:SF2">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_4G14350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002878016" description="Kelch repeat protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED11784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="40153" checksum="F79A3DC77B8EE90E" modified="2009-03-03" version="1">MRFLSIISALLSVAYCIEWIGQVGNLICNWAQLRGTIAISVYVPSSLSLLTIISQSTSSQFSNGQNGTVQNDGNFEGSLFRLDLSQTFNTITTNLTSLFSRVPQTTVSSSDYTDGVMWADTNELVLYGGLLRPSNSTSQPGSRSLYGYSINSTSSLHQPGFYYAEVPDNMTRYVTNGAGVSAPSERLGFYFGGMRGYDWGPISTMMNNMDSRFMQEVAIYDIASKIWYSQNTTGDIPSARALFCSVYASAADNSSHNIYIYGGYDGNDLEHTPFNDVYILSLPTFTWTRAYVGSDNDGRSGHQCIRVLPDQMLVVGGEFKDPTHCLPVLRNFNLNTLDFQNEYIPSEYASYEVPSPVIEVIGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUE7</accession>
    <name>B8MUE7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_109660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488542.1">
        <property type="nucleotide sequence ID" value="XM_002488497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUE7"/>
    <dbReference type="GeneID" id="8107198"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109660"/>
    <dbReference type="eggNOG" id="ENOG502SC56">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_30_1_1"/>
    <dbReference type="InParanoid" id="B8MUE7"/>
    <dbReference type="OMA" id="TEIWWIS"/>
    <dbReference type="OrthoDB" id="3548481at2759"/>
    <dbReference type="PhylomeDB" id="B8MUE7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF25">
        <property type="entry name" value="RNASE H TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="7"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED11786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="337" mass="38127" checksum="2C23D5FDEB8AFA3E" modified="2009-03-03" version="1">MPAEITLPKRAKFFTDGSGFDNGIGAAVYSSIGQAYKPVGSSDTHTVYAGELEGIDAALEILLRSQPCDDNPHEATIYTDNQAAIRATCQPGRSSGQYILRRIVRHLGLLRDNRSRWRVRLQWVPGHEGVPGNEKADQLAKLAAVEATRRTQENARIARISAPNQTTPHAARMSYIPNQSTILMAVCRQRLHAGFAKRWKEQWEHANHGRHLYRIIKAPTKMVLQLHEGLRRAWSSVLIQLQTGKSALRSFLASVRIEDSPQCECGLGDQDTAHVLIRCPTHINLRMETLWKEARETDYRKLLSEPQWVRQSIEFMMRTGLLTQFHHVTPLTTTRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUT0</accession>
    <name>B8MUT0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_109980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488574.1">
        <property type="nucleotide sequence ID" value="XM_002488529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUT0"/>
    <dbReference type="STRING" id="441959.B8MUT0"/>
    <dbReference type="GeneID" id="8107230"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109980"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066932_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUT0"/>
    <dbReference type="OMA" id="EIWAMEN"/>
    <dbReference type="OrthoDB" id="3261222at2759"/>
    <dbReference type="PhylomeDB" id="B8MUT0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="106"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED11818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="355" mass="40013" checksum="593C0E3D1FB45537" modified="2009-03-03" version="1">MPSDGVPVGRAATRTPEPPDRDEHENSPPRLRPKRTTKPPKDYAQEQEQEKETEQRKTHSQQKRKTQKRPATQCDAPTGDESATESEDLSEDLDTAKLVKELIKLRKEIRRQDEMHKEELKKVKEEFSAALAEVRQEMQTLTLLSRSESCSQNSYDDILHEIQSLRTSITTLDSANHLSYADVAHTPATNTSKIVDNKSDRTSAGSIRAVVEKEIRTMENHMNWRCRAVIMDPKNAYQIRIACRDEAEHQLVKKVAEAKISAGARVLRDKLYPIKVDSVRKAAVLDEIRAGATAAFSEENDTTVAKIAWLSSKESAKAYSSMVVYLTKGTDARRLLADGFFHAGRESSVTSVFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MVG5</accession>
    <name>B8MVG5_TALSN</name>
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        <submittedName>
            <fullName evidence="5">Reverse transcriptase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_007640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962663">
        <property type="protein sequence ID" value="EED11474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488790.1">
        <property type="nucleotide sequence ID" value="XM_002488745.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MVG5"/>
    <dbReference type="GeneID" id="8103293"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_007640"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_23_3_1"/>
    <dbReference type="InParanoid" id="B8MVG5"/>
    <dbReference type="OrthoDB" id="4368687at2759"/>
    <dbReference type="PhylomeDB" id="B8MVG5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="1090"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="4">
        <location>
            <begin position="1577"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="456"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="606"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="73"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED11474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1907" mass="215057" checksum="4BA315A6C644F2CC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MVI7</accession>
    <name>B8MVI7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspergillopepsin-2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_080280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962664">
        <property type="protein sequence ID" value="EED11414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488824.1">
        <property type="nucleotide sequence ID" value="XM_002488779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MVI7"/>
    <dbReference type="GeneID" id="8108980"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_080280"/>
    <dbReference type="HOGENOM" id="CLU_066466_0_1_1"/>
    <dbReference type="InParanoid" id="B8MVI7"/>
    <dbReference type="OMA" id="ANTFTAV"/>
    <dbReference type="OrthoDB" id="2862635at2759"/>
    <dbReference type="PhylomeDB" id="B8MVI7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00977">
        <property type="entry name" value="SCYTLDPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002878042" evidence="2">
        <location>
            <begin position="21"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED11414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="249" mass="25862" checksum="FCE1DFF3EB6E3349" modified="2009-03-03" version="1">MAFVLSGIKLLSLFCATVLAAAPQPYGPEVAHAANRRLSQLDGISNKTNADLTLNWSGAVLNAPPSGTTFTSVSAEFSVPTPKPANGRAGSSSVWVGIDGSTYPNAILQTGVYLSVTSNGSASFGAWYEWYPDYAGGFSGISINAGDRISLCVVSTSPSSGTVTIENLTNGQKASQSLTGTAPDSSSTLNGQNAEWIVEDYEEGSHLVVLDNFGIVTFNNVSVGLSNGSSLETEGAEIMNMLQYKAVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8LT46</accession>
    <name>B8LT46_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_069720</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340941.1">
        <property type="nucleotide sequence ID" value="XM_002340900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LT46"/>
    <dbReference type="FunCoup" id="B8LT46">
        <property type="interactions" value="23"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_008455_11_5_1"/>
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    <dbReference type="OrthoDB" id="3561359at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
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    </dbReference>
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        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS multidrug transporter, putative (AFU_orthologue AFUA_2G05840)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF7">
        <property type="entry name" value="DRUG_PROTON ANTIPORTER YHK8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF07690">
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    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="127"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
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            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="572" mass="64061" checksum="216BB0E4979F697D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTC3</accession>
    <name>B8LTC3_TALSN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_059950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_002339843.1"/>
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    </dbReference>
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    <dbReference type="PhylomeDB" id="B8LTC3"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED22497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="204" mass="22312" checksum="484DF407AAEDD67E" modified="2009-03-03" version="1">MARKGPGTDGPLQTALLESTSAATTRASEGQKIFSPIAAFLDKHRSQTTGLAPHLLRALTALSDDLASSTYVTITQYAPVKSTPTTHSKAHVKKPMPLMKQPPPDNWLFVRLLADHAARKMEAYTIYSSLWSSLNLNSLALKEVQATKTGFALCPSSPEALLTLEAQKEIISAFFVNCQIERSSRWVSYQVTNVPRKISQILDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTJ2</accession>
    <name>B8LTJ2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <ecNumber evidence="3">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_065260</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>oxaloacetate + ATP = phosphoenolpyruvate + ADP + CO2</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="3"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340457.1">
        <property type="nucleotide sequence ID" value="XM_002340416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTJ2"/>
    <dbReference type="FunCoup" id="B8LTJ2">
        <property type="interactions" value="281"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LTJ2"/>
    <dbReference type="GeneID" id="8101222"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_065260"/>
    <dbReference type="eggNOG" id="ENOG502QQI5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018247_2_0_1"/>
    <dbReference type="InParanoid" id="B8LTJ2"/>
    <dbReference type="OMA" id="MRYAGEM"/>
    <dbReference type="OrthoDB" id="184182at2759"/>
    <dbReference type="PhylomeDB" id="B8LTJ2"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00484">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.8.10:FF:000001">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.449.10:FF:000002">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase [ATP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00453">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015994">
        <property type="entry name" value="PEPCK_ATP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00224">
        <property type="entry name" value="pckA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006820">
        <property type="entry name" value="PRK09344.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006821">
        <property type="entry name" value="PRK09344.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006294">
        <property type="entry name" value="PEP_crbxkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00532">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED23070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="604" mass="66412" checksum="43F8B83738241EC3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTN3</accession>
    <name>B8LTN3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF659 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_070380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341012.1">
        <property type="nucleotide sequence ID" value="XM_002340971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTN3"/>
    <dbReference type="GeneID" id="8102644"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_070380"/>
    <dbReference type="eggNOG" id="KOG1121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_731564_0_0_1"/>
    <dbReference type="InParanoid" id="B8LTN3"/>
    <dbReference type="OMA" id="CHGHVIN"/>
    <dbReference type="OrthoDB" id="5074281at2759"/>
    <dbReference type="PhylomeDB" id="B8LTN3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="33"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED23625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="39720" checksum="4A5184129395BA62" modified="2009-03-03" version="1">MSNTASHDEFDLVSLASNPTEVTEGLETSLRYQRSASSVASTAKPQHKKRRSNNLLWEHTRPPKEGEDVRNKHKQEIYYCKHLTAEGVSRFAFNNIIKDIFGKQLEKQAGHDIDQEKHLRTAIQEAEFKEACVRLITVCNLPHSLLDWAEFWAVILSAIVAHWADTDTRSIECALLLLKEFKGSHSGEEQARVFIEVINEAGLQGKLGCLIMDNATSNDKMLRYITKETENFDPILYRVRCFGYIINPVIQAFLFGAKNHGGEDLMDQEEAISLAIKEIRLLTKETNRDIRDKVALGSLGKLHNINIWVRASTERYQNFIKAIGRAILIGNDTRWNSWSAEINVALTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTW7</accession>
    <name>B8LTW7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">12-oxophytodienoate reductase, putative</fullName>
            <ecNumber evidence="5">1.3.1.42</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_071930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.42" evidence="5"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341184.1">
        <property type="nucleotide sequence ID" value="XM_002341143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTW7"/>
    <dbReference type="STRING" id="441959.B8LTW7"/>
    <dbReference type="GeneID" id="8107670"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_071930"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_0_0_1"/>
    <dbReference type="InParanoid" id="B8LTW7"/>
    <dbReference type="OMA" id="PEKRCKF"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="PhylomeDB" id="B8LTW7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016629">
        <property type="term" value="F:12-oxophytodienoate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000059">
        <property type="entry name" value="N-ethylmaleimide reductase, FMN-linked"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF93">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="4">
        <location>
            <begin position="8"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED23797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="410" mass="46072" checksum="00111E0BD251938D" modified="2009-03-03" version="1">MHDRLQSKLFQPLVIANGKIKLNHRVVLAPLTRNRGVPLNSVSAPENPNRIWYPGDLMVEYYRQRTTKGGLLISEGVPPSLESNGMPGVPGLFTEEQAEGWRKVIDAVHEKGGVIYCQLWHAGRATIPQMTGSPPVSASASVWDSPDECYSHIPVGETKPVRYADHPPIELSKEHIKKTIGDYCRAAQTAVRIGFDGVEIHAGNGYLPEQFLSSNINKRTDEYGGSPEKRCRFVLELMDEIAKAIGEENLAIRLSPFGLFNQARSEQRVETWTYLCKSLKQTHPSLSYVSFIEPRYEQIFSYKEKDKFLQSWGLSDVSLDGFRQIFGDTPFFSAGGWDDTNSWGVIESGKYDALLYGRYFISNPDLVTRLQKGIPLAPYDRNRFYGPFEDDNAIGYTDYPGAEETARSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUN9</accession>
    <name>B8LUN9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar-sorting protein SNF7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar protein-sorting-associated protein 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_072860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341283.1">
        <property type="nucleotide sequence ID" value="XM_002341242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUN9"/>
    <dbReference type="FunCoup" id="B8LUN9">
        <property type="interactions" value="670"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LUN9"/>
    <dbReference type="GeneID" id="8099990"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_072860"/>
    <dbReference type="eggNOG" id="KOG1656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071097_1_0_1"/>
    <dbReference type="InParanoid" id="B8LUN9"/>
    <dbReference type="OMA" id="MKQIHGG"/>
    <dbReference type="OrthoDB" id="5592979at2759"/>
    <dbReference type="PhylomeDB" id="B8LUN9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904669">
        <property type="term" value="P:ATP export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070676">
        <property type="term" value="P:intralumenal vesicle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="181"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="21"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED23896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="223" mass="25377" checksum="4C07227C104CBECB" modified="2009-03-03" version="1">MWSWFGGQSAQKRRDAPKEAILKLREQLDMLQKREKHLENQIVEQEAIAKKNVTTNKNAAKAALRRKKMHEKNLEQTQNQVMQLEQQVYSIETANINQETLYAMDSAGNAMKRMHTGLTMEKVDSMMETLREQQALADDIAQVITTTPFGEQVDDDELESELADLEQETIDERMLKTGTVPVSDQLNRLPAAANGELKGKAKQTEEEDEEAELEKLRAEMAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUQ5</accession>
    <name>B8LUQ5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_073020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341299.1">
        <property type="nucleotide sequence ID" value="XM_002341258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUQ5"/>
    <dbReference type="STRING" id="441959.B8LUQ5"/>
    <dbReference type="GeneID" id="8106047"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_073020"/>
    <dbReference type="eggNOG" id="ENOG502QSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_0_2_1"/>
    <dbReference type="InParanoid" id="B8LUQ5"/>
    <dbReference type="OMA" id="HCVYGQK"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="PhylomeDB" id="B8LUQ5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="42675" checksum="1C276554F6598315" modified="2009-03-03" version="1">MAQYTWRHASNSNPDNPIPTDHPFNNVNNNEPLLVDTTTIAPTGYFYHRDDNDDNDSALGDDKASSTTSLNESIFNYQYENGRRYHAFRAGAYPLPNDEMEQDRMDMQHHIYLLLFGGELYRAPIGRNGQSDIGKALDIGCGTGLWAIDFADSHPETQVIATDLSYIQPTWVPPNLRFEIDDAESEWHFHEENIKFDYIHIRSMAGSIADWPRLLQRAYDHLSPGGWIELTEFETWASTDDNSLPLNSAYHQYQVLLCEAAASFGKEMNIAPHIHQLILNAGFVHVHKEVQKCPLSPWPKDRRLKELAMYMNLQMMESIEPYGLALFSRVLKWDTPRIYALLDGVRMDLRNLNYHMYSRVHCVYGQKPYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8LV19</accession>
    <name>B8LV19_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_061310</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340027.1">
        <property type="nucleotide sequence ID" value="XM_002339986.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340028.1">
        <property type="nucleotide sequence ID" value="XM_002339987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LV19"/>
    <dbReference type="STRING" id="441959.B8LV19"/>
    <dbReference type="GeneID" id="8109423"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_061310"/>
    <dbReference type="eggNOG" id="ENOG502SJK4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_0_0_1"/>
    <dbReference type="InParanoid" id="B8LV19"/>
    <dbReference type="OMA" id="ILYAWNL"/>
    <dbReference type="OrthoDB" id="4221392at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF151">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="30"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED22640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="379" mass="42914" checksum="4C56223E72C17050" modified="2009-03-03" version="1">MSSHGPDDLQPWSIAVTASMTSLAFICVCLRLLSRYERKQALWWDDYMIVFSMVWNLIVVVFICLMIHAGMGLHVAEVGVEGAVLMAKYLVAAEVLYVYNLVWTKLSFLLMYYRIFHFPYFKRWAYIIGGFVIIWVITVTFLFIFICVPVQKLWYPDLPGHCINQIGTWIANASSTIATDLVILILPIPQIWKLQLGKVEKVALTLTFCLGFFVVFASVYRFTVLFSYSAKDPTYTLAHTVGWTVIEMSAGIMSACLPTMRPALMFLARSIGIRHLVSPWGSRNTTAGLTENQGTRPLDSSNNHLRKDSQRAFTRIPDDKLGDRDDWTPVSADASLRPDKCAAMVTRAMGSRGDEESLEGDEVPLHNIRIQTDFKRTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8LV43</accession>
    <name>B8LV43_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phthiocerol/phthiodiolone dimycocerosyl transferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_061520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340051.1">
        <property type="nucleotide sequence ID" value="XM_002340010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LV43"/>
    <dbReference type="STRING" id="441959.B8LV43"/>
    <dbReference type="GeneID" id="8106001"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_061520"/>
    <dbReference type="eggNOG" id="ENOG502SI00">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029138_1_0_1"/>
    <dbReference type="InParanoid" id="B8LV43"/>
    <dbReference type="OMA" id="RTIRYIN"/>
    <dbReference type="OrthoDB" id="2548233at2759"/>
    <dbReference type="PhylomeDB" id="B8LV43"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031641">
        <property type="entry name" value="PapA_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034:SF1">
        <property type="entry name" value="CONDENSATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16911">
        <property type="entry name" value="PapA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phthiocerol/phthiodiolone dimycocerosyl transferase C-terminal" evidence="4">
        <location>
            <begin position="232"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="165"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED22664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="486" mass="54534" checksum="B2DD27B122BCBD02" modified="2009-03-03" version="1">MATTWTQTSPGVYQANLDGAETVYRKTATVFAPLKREHWRLHTICRFNFGPGYNGPTDKETALRQAWKALRYEFPGMTVAPDRSKKIYKTPDARTTKEWLEQTFFVEPKRTADEIIAEAVPLQEVPSLYYLPATSEILFFISHWRIDAMGSWMVTDRLFHHLANPSKSGLPKVPPPNEIEKISPSLEDAAGSPKVSTPEMDKVAADHIAAHHRNAIQMGGMPYKGDAITLPGSPKREAVIFTRESTQKVVSACKARGITVTAAIHAALAETVFAMGLPESREHDYVTVMPVNLRNYLKTPYNGDGHALQTYAGSITPRVPRHATFAKRTSYLVEYYKTRYDPKLIECLRPIYRYHAEALFKPLPAPAAAPEGTPATSNGNKRPPPGLPSGISINSLGVVEKYFAGKYGDSVDVATFTFGVSMITRQTMLYVWTWKGELTLSSEYNAAYHDPEEVREVMLSIKQVLEKELEIEQNRKREVEEQKEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8LV57</accession>
    <name>B8LV57_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_065620</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340494.1">
        <property type="nucleotide sequence ID" value="XM_002340453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LV57"/>
    <dbReference type="STRING" id="441959.B8LV57"/>
    <dbReference type="GeneID" id="8105588"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_065620"/>
    <dbReference type="eggNOG" id="KOG1417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027174_0_0_1"/>
    <dbReference type="InParanoid" id="B8LV57"/>
    <dbReference type="OMA" id="MLPHGPD"/>
    <dbReference type="OrthoDB" id="1689029at2759"/>
    <dbReference type="PhylomeDB" id="B8LV57"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000053">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01015">
        <property type="entry name" value="hmgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF0">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="14">
        <location>
            <begin position="14"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="13">
        <location>
            <begin position="292"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED23107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="458" mass="50866" checksum="84BE21DA9EEBAEA7" modified="2009-03-03" version="1">MPITQFSIPDPYSYLNGFNSYHESEAVKGALPTAQNSPQKPPYGLYAEKLSGTAFTAPRHENKQTWLYRILPSAAHANYQALSEDTYHTSLNFKSDGQNKLHYIPNQLRWNPFDLDEKVDWVHGLHLVAAAGNPTTKSGLGILLYAAGKDMGNEAIYSADGDFLIVPQHGVLDIQTEFGKIIVRPNEICVIPRGVKYRVKLPSGPVRGYICELYQGHFELPELGPIGSNGLANSRDFQAPVAAFDDDEGNPTDYTVISKFNNNLFSAKLNHTPFDVVAWHGNYYPFKYDLGRFNTIGSISYDHPDPSIFTVLTGQSDHPGTAIADFVIFPPRWLVAENTFRPPWYHRNVMSEFMGLIAGDYDAKIGGGFRPAGASLHNIMSAHGPDANAHEKASSVDLRPQKMGEGSMAFMFESTFMVGVSEWGLKSCEKVQEDYNAESWEPLKRHFVNPEKKGIPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVJ9</accession>
    <name>B8LVJ9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF636 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_074030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341405.1">
        <property type="nucleotide sequence ID" value="XM_002341364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVJ9"/>
    <dbReference type="STRING" id="441959.B8LVJ9"/>
    <dbReference type="GeneID" id="8101957"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_074030"/>
    <dbReference type="eggNOG" id="ENOG502RZUZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116419_0_0_1"/>
    <dbReference type="InParanoid" id="B8LVJ9"/>
    <dbReference type="OMA" id="PDEMVCI"/>
    <dbReference type="OrthoDB" id="406544at2759"/>
    <dbReference type="PhylomeDB" id="B8LVJ9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF44">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G09754)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED24018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="163" mass="18626" checksum="312F9592AEB7C915" modified="2009-03-03" version="1">MPMHLEGSCQCGGIEFELQSHTPVPYQLCACGICRKVAGYNGSVNIGGLANTLKIKKGKELIKKYNAIKNRGKPDEQKCSSERSFCSNCSTMLWLWDHHWPELIHPFAPAIDTELPVPDEMVCIMDSSKPAYVRWPEGKKVVREKYNDVSLEEWHKKHNLFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWP5</accession>
    <name>B8LWP5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RuvB-like helicase</fullName>
            <ecNumber evidence="15">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSTA_078040</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="15"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341829.1">
        <property type="nucleotide sequence ID" value="XM_002341788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWP5"/>
    <dbReference type="FunCoup" id="B8LWP5">
        <property type="interactions" value="1470"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LWP5"/>
    <dbReference type="GeneID" id="8105650"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_078040"/>
    <dbReference type="eggNOG" id="KOG1942">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028311_1_1_1"/>
    <dbReference type="InParanoid" id="B8LWP5"/>
    <dbReference type="OMA" id="RTLPYNK"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="PhylomeDB" id="B8LWP5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097255">
        <property type="term" value="C:R2TP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 15" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="63"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EED24442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="457" mass="49655" checksum="5F56D9AA9E9ABBAC" modified="2009-03-03" version="1">MVQISEVKGGSRENRTMAHTHIKGLGLRPDGTAESSADGWVGQATAREACGVVVDLIKAKKMAGRAVLLAGGPGTGKTALALAVSQELGTKVPFCPIVGSELYSAEVKKTETLMENFRRAIGLRVRETKEVYEGEVTELTPEEAENPLGGYGKTISHLIIGLKSYKGTKKLRLDPSIYEAIQKERVTVGDVIYIEANTGACKRVGRSDAYATEFDLEAEEYVPVPKGEVHKKKEIVQDVTLNDLDMANARPQGGQDLMSMLGQLSKPKKTEITDKLRAEINKVVSRYIDQGVAELIPGVLFIDEVHMLDIECFTYLNRALESPIAPIVILASNRGNTIIKGTGDVTAAHGIPPDLLARLLIVPTHPYTPDEIKTIIRLRAKTENLNITDPALDKVSEHGSKISLRYALQLLTPANILARVNGRPAIDVPDVTECEDLFIDAKRSATIVSQDNGNFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWU4</accession>
    <name>B8LWU4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_079320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341964.1">
        <property type="nucleotide sequence ID" value="XM_002341923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWU4"/>
    <dbReference type="GeneID" id="8107613"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_079320"/>
    <dbReference type="eggNOG" id="ENOG502S65D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_474221_0_0_1"/>
    <dbReference type="InParanoid" id="B8LWU4"/>
    <dbReference type="OMA" id="NMPGSTY"/>
    <dbReference type="OrthoDB" id="4497018at2759"/>
    <dbReference type="PhylomeDB" id="B8LWU4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED24577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="575" mass="63495" checksum="54CDF4BDF3D4362F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B8LX02</accession>
    <name>B8LX02_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_079900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002342022.1">
        <property type="nucleotide sequence ID" value="XM_002341981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LX02"/>
    <dbReference type="STRING" id="441959.B8LX02"/>
    <dbReference type="GeneID" id="8106642"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_079900"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022195_9_2_1"/>
    <dbReference type="InParanoid" id="B8LX02"/>
    <dbReference type="OMA" id="ICIRRRE"/>
    <dbReference type="OrthoDB" id="4219677at2759"/>
    <dbReference type="PhylomeDB" id="B8LX02"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED24635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="516" mass="59544" checksum="D4BF1EC36A01333F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXH1</accession>
    <name>B8LXH1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_066920</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340639.1">
        <property type="nucleotide sequence ID" value="XM_002340598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXH1"/>
    <dbReference type="FunCoup" id="B8LXH1">
        <property type="interactions" value="91"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LXH1"/>
    <dbReference type="GeneID" id="8109456"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_066920"/>
    <dbReference type="eggNOG" id="KOG0372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_8_0_1"/>
    <dbReference type="InParanoid" id="B8LXH1"/>
    <dbReference type="PhylomeDB" id="B8LXH1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="7">
        <location>
            <begin position="108"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="191"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED23252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="446" mass="48867" checksum="4BDBB3ACCA83A215" modified="2009-03-03" version="1">MSDLDKAIAQLRACRPIPEAQVRELCYKARELLIEEGNVVSVDAPVTICGDIHGQFHDLMELFRVGGDVPDTNYLFMGDFVDRGFYSLESFLLLLCLKVRYPDRITLIRGNHESRQITTVYGFYDECIRKYGSANVWRYCCEVFDYLALGALVLGASSELEPTTRVENSQIDGELETEVLNANGEVTSMSYRPRYRSSSDASTDTRDISPPRDISAAPGNTPSRAGPAGTGASGSSSGSYGTTAGAVLCVHGGLSPLVDSVDKIRLLDRKQEVPHEGAMCDLLWSDPDEIEGWGLSPRGAGFLFGGDIVKHFNHKNDLSLIARAHQLVMEGYKEMFDGGIVTVWSAPNYCYRCGNVAAILELGEDASNGGTIARTNGDIGRSNGVLHSDMGKHILGPGRRYRVFEAAAQDTRGMPAKKPVADYFLASYPLLSPQIFYPMLTLYENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXH7</accession>
    <name>B8LXH7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C6 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_078370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341865.1">
        <property type="nucleotide sequence ID" value="XM_002341824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXH7"/>
    <dbReference type="STRING" id="441959.B8LXH7"/>
    <dbReference type="GeneID" id="8108537"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_078370"/>
    <dbReference type="eggNOG" id="ENOG502SKCU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011237_1_0_1"/>
    <dbReference type="InParanoid" id="B8LXH7"/>
    <dbReference type="OMA" id="DNGWSTI"/>
    <dbReference type="OrthoDB" id="5420905at2759"/>
    <dbReference type="PhylomeDB" id="B8LXH7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED24478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="773" mass="87031" checksum="97EF595753E70080" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXK1</accession>
    <name>B8LXK1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_078590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341889.1">
        <property type="nucleotide sequence ID" value="XM_002341848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXK1"/>
    <dbReference type="STRING" id="441959.B8LXK1"/>
    <dbReference type="GeneID" id="8104213"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_078590"/>
    <dbReference type="HOGENOM" id="CLU_1897600_0_0_1"/>
    <dbReference type="InParanoid" id="B8LXK1"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="PhylomeDB" id="B8LXK1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED24502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="134" mass="14858" checksum="79D8EF97E6F13F9F" modified="2009-03-03" version="1">MTTAIEQSVAYYNGKVYTLNDSRQVAEDFIVTPQGTFSTVGTRNEVLRIARAYGIITYNLHGHRDNTLKLDIAAHSVYASKFLANEREGSFKALIDQTPKLATKHVRTSFVKILLDGVPLPPLFSSAGNIEQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXK6</accession>
    <name>B8LXK6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoserine phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_078630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341895.1">
        <property type="nucleotide sequence ID" value="XM_002341854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXK6"/>
    <dbReference type="FunCoup" id="B8LXK6">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LXK6"/>
    <dbReference type="GeneID" id="8104219"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_078630"/>
    <dbReference type="eggNOG" id="ENOG502QRU0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058495_1_0_1"/>
    <dbReference type="InParanoid" id="B8LXK6"/>
    <dbReference type="OMA" id="VPFHEFD"/>
    <dbReference type="OrthoDB" id="10014216at2759"/>
    <dbReference type="PhylomeDB" id="B8LXK6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050849">
        <property type="entry name" value="HAD-like_hydrolase_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181:SF2">
        <property type="entry name" value="PHOSPHORIC MONOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181">
        <property type="entry name" value="UPF0655 PROTEIN YCR015C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED24508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="268" mass="29749" checksum="717634B46E425542" modified="2009-03-03" version="1">MGSTDPSNLPYIQTSPKIIFFTDFDGTITLKDSNDFLTDNLGYGQVKRKQGNEDVLTGKATFRDAFRDMLDSVKPGFGECIEILKQNMELDPYFTEFYNWAKENNVPIVVLSSGMVPIISALFEKLLGHKPDPKHLTIVANDVESRDGKDINTPGGWQIKFHDDSHFGHNKSLEIKPYAALPADKRPTLLYAGDGVSDLSAAAETDLLFAKKGHDLIRYCEREGMPFTVFEDWSTILATTKDIYYGKVSVKNVAEQGLAKVKAGEAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8LY43</accession>
    <name>B8LY43_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSTA_067280</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340675.1">
        <property type="nucleotide sequence ID" value="XM_002340634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LY43"/>
    <dbReference type="FunCoup" id="B8LY43">
        <property type="interactions" value="1477"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LY43"/>
    <dbReference type="GeneID" id="8101193"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_067280"/>
    <dbReference type="eggNOG" id="KOG0925">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_5_11_1"/>
    <dbReference type="InParanoid" id="B8LY43"/>
    <dbReference type="OMA" id="MKVYPLY"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="PhylomeDB" id="B8LY43"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17973">
        <property type="entry name" value="DEXHc_DHX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000324">
        <property type="entry name" value="pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000003">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044756">
        <property type="entry name" value="DHX15_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF109">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="103"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="293"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EED23288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="759" mass="85852" checksum="EF4FB9EF1E6D7FA9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8LY97</accession>
    <name>B8LY97_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BYS1 domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_067740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340729.1">
        <property type="nucleotide sequence ID" value="XM_002340688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LY97"/>
    <dbReference type="STRING" id="441959.B8LY97"/>
    <dbReference type="GeneID" id="8107348"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_067740"/>
    <dbReference type="eggNOG" id="ENOG502SP0S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083650_1_1_1"/>
    <dbReference type="InParanoid" id="B8LY97"/>
    <dbReference type="OrthoDB" id="3682664at2759"/>
    <dbReference type="PhylomeDB" id="B8LY97"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195:SF4">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877299" evidence="1">
        <location>
            <begin position="19"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="152" mass="16274" checksum="FD6FB83E53471BFB" modified="2009-03-03" version="1">MKFISATLVGALLPLAHAVGNAIVFNNCTNTIYVWSVGSSIGNYQALANGESYTEQYRHDDQTGGITLKVTAVADGIYNSAPELDYGYTLDNQTIWYDISDVNGDPFANSTVALVPANGACQSFHWADGISPPGIHTASCSAEVDWRNGCYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZ28</accession>
    <name>B8LZ28_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short chain dehydrogenase (AtsC), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_083050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478035.1">
        <property type="nucleotide sequence ID" value="XM_002477990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZ28"/>
    <dbReference type="FunCoup" id="B8LZ28">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="GeneID" id="8105183"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_083050"/>
    <dbReference type="eggNOG" id="KOG1611">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_2_1"/>
    <dbReference type="InParanoid" id="B8LZ28"/>
    <dbReference type="OMA" id="PHFKGPA"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="PhylomeDB" id="B8LZ28"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF3">
        <property type="entry name" value="CHAIN DEHYDROGENASE (ATSC), PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="266" mass="28901" checksum="3732F3876D30FF91" modified="2009-03-03" version="1">MPSYLITGASRGIGYELLRQLSADPNNTVIGLVRNKPATDARVSTELSERKNIFVIHGDMTDVQSLKTAVQETSKITGGSLDVLIANAVYLSDFSQYEGIGNLEIEPLGEDMRRNFEANVIGNINLFSLSIPLIRKGNIKKVVAISSGMSDENLVAKMRISSAAPYAISKAALNMVVTKFHAQYADEGILFMAVCPGVVNTDFATTPEQQAKIGTMFQKFVKYAPHFKGPAHVQDAVKDVLQVVDKATIEANGGIFVSHYGNKEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZA7</accession>
    <name>B8LZA7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_088960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478623.1">
        <property type="nucleotide sequence ID" value="XM_002478578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZA7"/>
    <dbReference type="STRING" id="441959.B8LZA7"/>
    <dbReference type="GeneID" id="8104863"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_088960"/>
    <dbReference type="HOGENOM" id="CLU_1262265_0_0_1"/>
    <dbReference type="InParanoid" id="B8LZA7"/>
    <dbReference type="OMA" id="NSVEAQF"/>
    <dbReference type="OrthoDB" id="4828117at2759"/>
    <dbReference type="PhylomeDB" id="B8LZA7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="219" mass="23606" checksum="1537EAC625A2796F" modified="2009-03-03" version="1">MVNWQASDAGFRFLAAVFADPSIRPDANQVAKLFGRGATSRAVDHQFSKIRRASKELVAEAQKNGVEISATPRAARTPRTPRSGGVFRSGASTKAHSKDKGLDTPTKSRKGTLSAGGLSMMDAITVDTDKDDESVISVAKFDTMSIQSDTKEESEHDTVEPKREADLTTPSIQLFGQRPTTPRVDSRSNGYVLGTGKKSTVTANVASEFSMDDIFGNYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZR5</accession>
    <name>B8LZR5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_080800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477810.1">
        <property type="nucleotide sequence ID" value="XM_002477765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZR5"/>
    <dbReference type="STRING" id="441959.B8LZR5"/>
    <dbReference type="GeneID" id="8101385"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_080800"/>
    <dbReference type="eggNOG" id="ENOG502SJMV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_459413_0_0_1"/>
    <dbReference type="InParanoid" id="B8LZR5"/>
    <dbReference type="OMA" id="CAWYSYP"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="PhylomeDB" id="B8LZR5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED20847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="599" mass="66791" checksum="EC0170E7FC3D47A0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8M044</accession>
    <name>CBPYA_TALSN</name>
    <protein>
        <recommendedName>
            <fullName>Carboxypeptidase Y homolog A</fullName>
            <ecNumber>3.4.16.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">cpyA</name>
        <name type="ORF">TSTA_083730</name>
    </gene>
    <organism>
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Release of a C-terminal amino acid with broad specificity.</text>
            <dbReference type="EC" id="3.4.16.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.5"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478104.1">
        <property type="nucleotide sequence ID" value="XM_002478059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M044"/>
    <dbReference type="SMR" id="B8M044"/>
    <dbReference type="FunCoup" id="B8M044">
        <property type="interactions" value="887"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M044"/>
    <dbReference type="ESTHER" id="penmq-cbpya">
        <property type="family name" value="Carboxypeptidase_S10"/>
    </dbReference>
    <dbReference type="MEROPS" id="S10.001"/>
    <dbReference type="GlyCosmos" id="B8M044">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="GeneID" id="8101466"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_083730"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008523_10_4_1"/>
    <dbReference type="InParanoid" id="B8M044"/>
    <dbReference type="OMA" id="GDWMKPF"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="PhylomeDB" id="B8M044"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.410:FF:000001">
        <property type="entry name" value="Carboxypeptidase Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008442">
        <property type="entry name" value="Propeptide_carboxypepY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05388">
        <property type="entry name" value="Carbpep_Y_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0121">Carboxypeptidase</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000407480" evidence="1">
        <location>
            <begin position="18"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000407481" description="Carboxypeptidase Y homolog A">
        <location>
            <begin position="135"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="529"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="518"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="189"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="392"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="553" mass="61898" checksum="A1EB9702FD8701F4" modified="2009-03-03" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8M061</accession>
    <name>B8M061_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_083900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478121.1">
        <property type="nucleotide sequence ID" value="XM_002478076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M061"/>
    <dbReference type="GeneID" id="8101483"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_083900"/>
    <dbReference type="HOGENOM" id="CLU_1489491_0_0_1"/>
    <dbReference type="InParanoid" id="B8M061"/>
    <dbReference type="OrthoDB" id="4225535at2759"/>
    <dbReference type="PhylomeDB" id="B8M061"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="211" mass="23594" checksum="2BCECEF85DA51F4B" modified="2009-03-03" version="1">MVVPSQPVIRRKAVKSVKPRPKPPGQSRRLPCAIDSIENMHSSFHDAPPTKKLSSAAGITIEEYVSKKPQYDFDNFVPRSIQCPVATSQAFDDAYDYLFKHLSGGCNGLNIIPYPGLREDDDESEEKVSNSAFAALVYVEPGVSGRWEKIEKGLKRIFNAAAIEDGEEPKWLCEGIIFRLCAANSSRYWQNGPDWALLNEIDLRTQVPLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0A9</accession>
    <name>B8M0A9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_084370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478169.1">
        <property type="nucleotide sequence ID" value="XM_002478124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0A9"/>
    <dbReference type="GeneID" id="8101530"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_084370"/>
    <dbReference type="eggNOG" id="ENOG502SYAY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1469157_0_0_1"/>
    <dbReference type="InParanoid" id="B8M0A9"/>
    <dbReference type="OrthoDB" id="5017668at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED21206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="160" mass="18856" checksum="BB0DBBDC31736F81" modified="2009-03-03" version="1">MSTTGNRNKSTERFKCRKILSDHLKPLNVRTIPDPTDEYVWKWKEGKAHLLKTPLSKLSTKAFLELSNAVKSGSVWAIKRDRDSTTEEVMTELDEIKAREKRLHIKNACLQKTIQRHTRRQEKYKRVLATSEERLREMLFHLQEAQRSFDSLDPPVFSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0H2</accession>
    <name>B8M0H2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_085000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478232.1">
        <property type="nucleotide sequence ID" value="XM_002478187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0H2"/>
    <dbReference type="STRING" id="441959.B8M0H2"/>
    <dbReference type="GeneID" id="8106106"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_085000"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_4_1"/>
    <dbReference type="InParanoid" id="B8M0H2"/>
    <dbReference type="OMA" id="GEIRPMA"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="PhylomeDB" id="B8M0H2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED21269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="346" mass="38027" checksum="8F486B1E5414FFB0" modified="2009-03-03" version="1">MATPQFRLTPEKEASRSQWLHRQFLGKTPPLTKNDVDLTGKTAIVTGSNTGLGLETAGHLLDLGLTRLILAVRTVSKGERAREGLLAKRDPASCQIDVWNIDMSSYDSITEFVERAKTLDRLDIAVLNAGHFKELETFNSSTGYEECIQINYLSTMLLTILLLPLLKANPGAHPGRLVIVSSDMAAWAKFTERTERPILAAYKKKAAKWDMGERYATSKLLGQLFITKLADQIPASAVIVDLVNPGLCYGTDLARDGDGRLKGLLFKAAFRTFGKAPAIGALAIVHAAVSFDESAHGQYTEDGELRPLAPIIYKQEGKELTNQVWEETLAELSFAPIHESLKAFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0X2</accession>
    <name>B8M0X2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_089910</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478715.1">
        <property type="nucleotide sequence ID" value="XM_002478670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0X2"/>
    <dbReference type="GeneID" id="8108079"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_089910"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_277745_0_0_1"/>
    <dbReference type="InParanoid" id="B8M0X2"/>
    <dbReference type="OrthoDB" id="4226988at2759"/>
    <dbReference type="PhylomeDB" id="B8M0X2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="9">
        <location>
            <begin position="953"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="228"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="625"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="635"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED21752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1141" mass="125359" checksum="E3927161EAAD1C35" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8M149</accession>
    <name>B8M149_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arrestin domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_082240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477954.1">
        <property type="nucleotide sequence ID" value="XM_002477909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M149"/>
    <dbReference type="STRING" id="441959.B8M149"/>
    <dbReference type="GeneID" id="8107682"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_082240"/>
    <dbReference type="eggNOG" id="KOG3780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045296_0_0_1"/>
    <dbReference type="InParanoid" id="B8M149"/>
    <dbReference type="OMA" id="LNCHENI"/>
    <dbReference type="OrthoDB" id="2238745at2759"/>
    <dbReference type="PhylomeDB" id="B8M149"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="385"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED20991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="435" mass="48575" checksum="4F139EB5AC48E1F7" modified="2009-03-03" version="1">MASVQERKHRKIKSLLLPSSQSGLSTSISLLEQAIFVNASLCTPSVLRGCVKLDVSKHVQLRDLSIRFTGLNKVHKFGRFYDKERVIDQTWLVPRLEARSSSLVHVIQRDAKLWPILQPGHYVYNFELTLNETLPETFDVGGCKLSYDIQAVANISGHRPQSSPSQEVAVVHCPHDEFYLHEASQISLSRIWNKQILYNVELADKGAAIGGNIPISIRIGCSDIMYLAVQVYLAQKIQFPGIPGRQSQLRKMLLLKTKCNDLSTGKFRETPSLRLDQESDVTVIAGSVPLLNEPNAQLRLHPDVHFKKVTATHTIMFLIDITIPNPQDSRKTTVCRLTAETPFCVRTSQTHLYGLSVPEYSETNNLATDSDHFNSSRLLPPPFPETSSRQPSETSSTIDTEFAWSRSPSTYSLSSDELKPVAPVNPPPAYESICG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1H2</accession>
    <name>B8M1H2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Polyadenylation factor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_091080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
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    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="179"/>
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        <location>
            <begin position="221"/>
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            <begin position="263"/>
            <end position="298"/>
        </location>
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            <begin position="306"/>
            <end position="338"/>
        </location>
    </feature>
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        <location>
            <begin position="376"/>
            <end position="408"/>
        </location>
    </feature>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="RuleBase" id="RU369034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED21868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="587" mass="64942" checksum="8CAACF0847B47777" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1R2</accession>
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            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
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        <name evidence="5" type="ORF">TSTA_093950</name>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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        </lineage>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_093950"/>
    <dbReference type="eggNOG" id="KOG4389">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_10_5_1"/>
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    <dbReference type="OMA" id="YGTWAFL"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="25"/>
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        <location>
            <begin position="26"/>
            <end position="609"/>
        </location>
    </feature>
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            <begin position="59"/>
            <end position="549"/>
        </location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED22149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="609" mass="66289" checksum="A80BB6250E2B9DE5" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2T4</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">TSTA_094350</name>
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    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002479107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2T4"/>
    <dbReference type="STRING" id="441959.B8M2T4"/>
    <dbReference type="GeneID" id="8103763"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_094350"/>
    <dbReference type="eggNOG" id="ENOG502RY7V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_395924_0_0_1"/>
    <dbReference type="InParanoid" id="B8M2T4"/>
    <dbReference type="OMA" id="CSCRIAE"/>
    <dbReference type="OrthoDB" id="4495335at2759"/>
    <dbReference type="PhylomeDB" id="B8M2T4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42041">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42041:SF1">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="378"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="615"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="90"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="621"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="654"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED22189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="678" mass="76015" checksum="C7CD2E29A7C19883" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2Z9</accession>
    <name>B8M2Z9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="10">DOHH</shortName>
            <ecNumber evidence="10">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LIA1</name>
        <name evidence="12" type="ORF">TSTA_092170</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="10">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the deoxyhypusine hydroxylase family.</text>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
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        <property type="entry name" value="ARM-like"/>
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        <property type="entry name" value="HEAT_type_2"/>
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        <property type="entry name" value="PBS_lyase_HEAT"/>
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    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
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        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="EZ_HEAT"/>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8 10" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="11">
        <location>
            <begin position="247"/>
            <end position="287"/>
        </location>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="66"/>
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        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
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        <location>
            <position position="67"/>
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        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
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        <location>
            <position position="99"/>
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        <ligand>
            <name>Fe cation</name>
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            <label>1</label>
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        <location>
            <position position="100"/>
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        <ligand>
            <name>Fe cation</name>
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            <label>1</label>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="233"/>
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        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
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        <location>
            <position position="234"/>
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        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="266"/>
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        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
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        <location>
            <position position="267"/>
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        <ligand>
            <name>Fe cation</name>
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            <label>2</label>
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        <source>
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        <source>
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            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
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            <dbReference type="EMBL" id="EED21975.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="326" mass="35746" checksum="F1828090BAC141D0" modified="2009-03-03" version="1">MAEVSHATVAALRKTLTSETEPLARRFRALFSLKYVACLNPPTEQTVPAIEAIAAAFTSPSALLKHELAYCLGQSKKADAVPHLLHVLKDKGEDTMCRHEAAEALGALGFEDSLALLKELRDDKNEPEVVRETCDIAVDRILWEISEEKKNEKIRPSDFASIDPAPPLPQAAKEPSIPELESTLLDTKLPLFKRYRAMFALRDLASPPDLPTAVPAINVLSKGLKDPSALFRHEIAFVFGQLCHPASIPSLTSTLSDLNEMGMVRHEAAEALGSLGDEEGVEETLKQFLNDPEQVVRDSIIVALDMAEYEKNGDKEYALLPETTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8M338</accession>
    <name>B8M338_TALSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_092600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="108"/>
            <end position="146"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
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        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="549" mass="61120" checksum="853697E85CAD9EE7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8M399</accession>
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        <recommendedName>
            <fullName evidence="9">MFS multidrug transporter</fullName>
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        <name evidence="7" type="ORF">TSTA_095170</name>
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            <taxon>Eurotiales</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_095170"/>
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    <dbReference type="HOGENOM" id="CLU_013756_2_1_1"/>
    <dbReference type="InParanoid" id="B8M399"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="PhylomeDB" id="B8M399"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED22271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="53202" checksum="90E3E19EA01B8A03" modified="2009-03-03" version="1">MANANEETSLLSTATDSRLPEEESVSQRTSYYSIENRRMLYTIASLCVVLLIFDLSNYIAVVPQTAIYEEIVCRGYYSSEKLALGNPSGDKCKVEPIQSEVALISGWRDTFDTIPENGPPWSGWLFAQRCLGENCLFPHILPLRFMWFSGAFQLIGGGATSVASMIYVMAVDVCPPEHRTTAFSQITAAALISEFLSVQLSAWLMSISPWIPYLGSSSIFTIGLISLIVLIPETYIPKSESLIVDTSTEEENLTSALGRPSWIVRLASRIGQLKNMLGAIFIWMRRNVPAMLIISSFFIANIGKQTSVILLQYITQKFHWTFAQHNKAAFVISLRAAGNLLVLTILLPTLSEFLARRAHLDRAAKDKRLSQISVVTVILGYLLIFVADSPVELSAEVILSALVSAFTVTARSTLSSLVDQKYLATVYIGLSVMAYSGIVAGGPLLASSFRWGMKLGGFWIGLPFIVAAGLYVVILLVISMTRMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3D7</accession>
    <name>B8M3D7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_095580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479272.1">
        <property type="nucleotide sequence ID" value="XM_002479227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3D7"/>
    <dbReference type="GeneID" id="8105869"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_095580"/>
    <dbReference type="eggNOG" id="ENOG502SJX7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021158_0_0_1"/>
    <dbReference type="InParanoid" id="B8M3D7"/>
    <dbReference type="OMA" id="PTREFWM"/>
    <dbReference type="OrthoDB" id="3554464at2759"/>
    <dbReference type="PhylomeDB" id="B8M3D7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF56">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED22309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="49041" checksum="3E890DEE83E5466D" modified="2009-03-03" version="1">MGRWTYTPPRMPNGILIDGKKLFELLRADNPQSYIWDVDLLIQEIEETFGAEVTEVPEYVDGAFHKAVWCVLSNGEEIIARLSKADINRPHEKSLPVPMQISAAEYEIALYEALYPEAELRLAALLYNRIPELHEGIDDDSKDIIGRRLCVFEAPEGRKNMWWELGPEDKVCILKQAAEIRAALFNFNPQPKFIATWLPKRLASAHTPISLPVAITPTRNFCIALFRAKIEATIRNMDDIIGWPQDNNTVGPFAAAAKQSLLRLVPYILPSDNRGNIFYRFVIDHGDYGIWNMTATTDEYEKPYITSVYEWDSSCIVPAIFSDPKFVTNISFVTDEYANPSIARSSKFKSKYIKPARRAKFMAWSRQYFNTLYDAAPAYETIIREGSDARYLWFALQSRSLHNIEPEIYFGELGIWAKKKLREFGVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3S8</accession>
    <name>B8M3S8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_038760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481105.1">
        <property type="nucleotide sequence ID" value="XM_002481060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3S8"/>
    <dbReference type="FunCoup" id="B8M3S8">
        <property type="interactions" value="990"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M3S8"/>
    <dbReference type="GeneID" id="8107918"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_038760"/>
    <dbReference type="eggNOG" id="KOG0176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_4_2_1"/>
    <dbReference type="InParanoid" id="B8M3S8"/>
    <dbReference type="OMA" id="RSMIDHA"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="PhylomeDB" id="B8M3S8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03753">
        <property type="entry name" value="proteasome_alpha_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000015">
        <property type="entry name" value="Proteasome subunit alpha type-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033812">
        <property type="entry name" value="Proteasome_alpha_type_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED20671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="245" mass="26736" checksum="AA2327AF54486FC7" modified="2009-03-03" version="1">MFIARSEYDRGINTFSPEGRLFQVEYSLEAIKLGSTAIGVATSEGVVLGVEKRVTSSLLETSSVEKIVEIDQHIGCAMSGLQADARSMIEHARVECQNHAFHFAESLRVESCTQAICDLALRFGEGAEGEESVMSRPFGVALLIAGYDEDGPQLYHAEPSGTFYRYDAKAIGSGSEGAQAELQNEYHRSLTLAEAETLVLKTLKQVMEEKLDAKNVQLASVTKEKGFRIYDEEEMGRAVGQLGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3T6</accession>
    <name>B8M3T6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH:ubiquinone oxidoreductase intermediate-associated protein 30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_038840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CIA30 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481113.1">
        <property type="nucleotide sequence ID" value="XM_002481068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3T6"/>
    <dbReference type="STRING" id="441959.B8M3T6"/>
    <dbReference type="GeneID" id="8107926"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_038840"/>
    <dbReference type="eggNOG" id="ENOG502S3C5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059028_3_1_1"/>
    <dbReference type="InParanoid" id="B8M3T6"/>
    <dbReference type="OMA" id="IMVRSFF"/>
    <dbReference type="OrthoDB" id="4226926at2759"/>
    <dbReference type="PhylomeDB" id="B8M3T6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010257">
        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF19">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="3">
        <location>
            <begin position="16"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED20679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="273" mass="30928" checksum="E28C037A9277DD31" modified="2009-03-03" version="1">MTVTRKYLFGGDTPWSKQDWTTCDDRIRGGASASRLSIKPSTVDHIDNQPYSSSAFFHGFLDITTLGGAGFASQRNTTYTLNWHLEKYDGIEFIVGKSDGKRYSFVLKDEMLPKRPDGREQSSLNWEYEFVVPATSDCEDRTREGTVFRAKWCDFEPTYRGKPQEGLTRRILPRNIKRITLMMRSFFGMQSGDFEVEIKSIAVFKEGNQVDGAAPLRQDGEDIAEKLRNEYTPPLSSRAESFGSKTAKETDEPKRRGRPNSLLLRLLSSCCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4I2</accession>
    <name>B8M4I2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Nuclear transport factor 2</fullName>
            <shortName evidence="4">NTF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_024990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Facilitates protein transport into the nucleus. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479611.1">
        <property type="nucleotide sequence ID" value="XM_002479566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4I2"/>
    <dbReference type="FunCoup" id="B8M4I2">
        <property type="interactions" value="1188"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M4I2"/>
    <dbReference type="GeneID" id="8106716"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_024990"/>
    <dbReference type="eggNOG" id="KOG2104">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131642_0_0_1"/>
    <dbReference type="InParanoid" id="B8M4I2"/>
    <dbReference type="OMA" id="QFVEYYY"/>
    <dbReference type="OrthoDB" id="6507044at2759"/>
    <dbReference type="PhylomeDB" id="B8M4I2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000005">
        <property type="entry name" value="Nuclear transport factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="5">
        <location>
            <begin position="7"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00053082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED19177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="126" mass="14019" checksum="317FB563816AD929" modified="2009-03-03" version="1">MADFSSIAQQFVQFYYKTFDEGRANLAALYRDNSMLTFENDAKLGTAAIIEKLTELPFQKVQHQVATLDAQPSSESGGILVLVTGALLVDEEQKPMNYTQAFQLLPDGAGSYFVYNDVFRLIYSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4K3</accession>
    <name>B8M4K3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CHA4 activatory protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_025190</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479632.1">
        <property type="nucleotide sequence ID" value="XM_002479587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4K3"/>
    <dbReference type="STRING" id="441959.B8M4K3"/>
    <dbReference type="GeneID" id="8106736"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_025190"/>
    <dbReference type="eggNOG" id="ENOG502RXDV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007003_4_4_1"/>
    <dbReference type="InParanoid" id="B8M4K3"/>
    <dbReference type="OMA" id="CRLAVIF"/>
    <dbReference type="OrthoDB" id="4212895at2759"/>
    <dbReference type="PhylomeDB" id="B8M4K3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED19198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="384" mass="44169" checksum="67964E284485595A" modified="2009-03-03" version="1">MGSPDIPSPVATRAKGRKYGFACLSCRRKKIKCDGSKPICINCNKSKESCVYRDNPAFVGYLAEELRKSKIRVQELETVIKELLILDSESRHLRIAALVSEMERQRSSPSPGSSTLLESDESHAKLSVSYGGSVEYNIDENGRQQYFGATSRFHTLSEASEHLENVLDTTTEQEYSDIEEYHRKWHLSNSRWQASWEKQAHDNIPKYTDVDASLCSQLLDVYWTWQGPLHNYVYRRCFFRDMAIGGPYFSLFLLNVMFAHAMRHMPEEDPRFKPFERGEFFMKRAMLLLLDEMKESKPKIPTIQGLLILGGRQCAVGKSSEGWLYTGMAIRMITDLGLHLRKGRNAMLKEYEPDDLEVRKRLYLSCYAWDKCDTVLLKITPDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4N2</accession>
    <name>B8M4N2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_025440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479661.1">
        <property type="nucleotide sequence ID" value="XM_002479616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4N2"/>
    <dbReference type="GeneID" id="8107956"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_025440"/>
    <dbReference type="HOGENOM" id="CLU_706326_0_0_1"/>
    <dbReference type="InParanoid" id="B8M4N2"/>
    <dbReference type="OrthoDB" id="9975959at2759"/>
    <dbReference type="PhylomeDB" id="B8M4N2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055530">
        <property type="entry name" value="DUF7104"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23397">
        <property type="entry name" value="DUF7104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED19227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="391" mass="43349" checksum="1D20728BE8E318A5" modified="2009-03-03" version="1">MDELVRKAMQLAEALKKPPDSVPWKDDEPWAQPHYSWLEKKGEWQTASTVSSFERYEKDIPATTDVIIATASNPVHGLGLTSLFLTQERVQVSLDAAMMEGVIVASPVLKAAAKNTARGVELLKTLLSRCRDDISITPELVAAAAANRAPGAELVTLLLDHRENVGHLEDGDSSLTEGLMIEAASNVGCAVQVLARLLRRHWTHIPLTDEAILAVEDNSLSVLMSLLHLLPKEFPVLESMTDTFSAENSFHYMLKEMTLLVQRLEVEGIVTQNVIAKVAERCGEELVLFLLDQADEDVQLTPALLKAITENQRYGPQISKILLDLHCDIVAPEKFLITLAQTNWKSLARFLRKALKKYGDYLPVTDKVLEAVTGASSPREDIVTLLMERRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4P1</accession>
    <name>B8M4P1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HhH-GPD family base excision DNA repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_025530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479670.1">
        <property type="nucleotide sequence ID" value="XM_002479625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4P1"/>
    <dbReference type="STRING" id="441959.B8M4P1"/>
    <dbReference type="GeneID" id="8107965"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_025530"/>
    <dbReference type="eggNOG" id="ENOG502QRUG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_9_1_1"/>
    <dbReference type="InParanoid" id="B8M4P1"/>
    <dbReference type="OrthoDB" id="5607at2759"/>
    <dbReference type="PhylomeDB" id="B8M4P1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000702">
        <property type="term" value="F:oxidized base lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203:SF1">
        <property type="entry name" value="HYPOTHETICAL BASE EXCISION DNA REPAIR PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="2">
        <location>
            <begin position="190"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="407" mass="44236" checksum="EBBDA4E33BF508D5" modified="2009-03-03" version="1">MPANSVPALQTPTKKPTKPTSSNNKRQKSNSSTIKASFAVSKSSNSASKKRKIIHEIDINELPHNLGKLATQIVRDALDGPQDIKNETSSPHSPKRVKLESIQPESKAKDVESAKIKSKKGAAKYGLTPGVSPFPEFSHPTVEECEEVNRLLSTVHGEVKAPTKVPQPSLTVTGCGEVPSVLDALIRTVLSGATTGANSAKAFKGLVDRFGILEMGIGKGSVDWNAVRVAPINEVFEAMKSGGLATTKSKYIKEILNMVYEENLARKEAHIKSEEEGNSGPAGAEHESKAQKEVEIALTDENVLSLDWIHALDKEEAMLELIKFPGIGPKTAACVVLFCLQRPCFAVDTHIFRICKWLGWLPSADTKRVTEITAFSHLEVRIPDHLKAVLGVERLQGRKVMDGKMDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5H9</accession>
    <name>B8M5H9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_031330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480307.1">
        <property type="nucleotide sequence ID" value="XM_002480262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5H9"/>
    <dbReference type="STRING" id="441959.B8M5H9"/>
    <dbReference type="GeneID" id="8107744"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_031330"/>
    <dbReference type="eggNOG" id="ENOG502RPQ7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024519_1_0_1"/>
    <dbReference type="InParanoid" id="B8M5H9"/>
    <dbReference type="OMA" id="WRYELDP"/>
    <dbReference type="OrthoDB" id="5280838at2759"/>
    <dbReference type="PhylomeDB" id="B8M5H9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38119:SF1">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38119">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="59601" checksum="105805008E3F70E1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8M661</accession>
    <name>B8M661_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cysteine proteinase 1, mitochondrial</fullName>
            <ecNumber evidence="8">3.4.22.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_023940</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.</text>
    </comment>
    <comment type="function">
        <text evidence="6">The normal physiological role of the enzyme is unknown, but it is not essential for the viability of yeast cells. Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. Acts as a repressor in the GAL4 regulatory system, but this does not require either the peptidase or nucleic acid-binding activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.</text>
            <dbReference type="EC" id="3.4.22.40"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homohexamer. Binds to nucleic acids. Binds single-stranded DNA and RNA with higher affinity than double-stranded DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.40" evidence="8"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479495.1">
        <property type="nucleotide sequence ID" value="XM_002479450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M661"/>
    <dbReference type="FunCoup" id="B8M661">
        <property type="interactions" value="726"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M661"/>
    <dbReference type="MEROPS" id="C01.085"/>
    <dbReference type="GeneID" id="8109576"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_023940"/>
    <dbReference type="eggNOG" id="KOG4128">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038600_0_1_1"/>
    <dbReference type="InParanoid" id="B8M661"/>
    <dbReference type="OMA" id="QSYTFFW"/>
    <dbReference type="OrthoDB" id="2666448at2759"/>
    <dbReference type="PhylomeDB" id="B8M661"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070005">
        <property type="term" value="F:cysteine-type aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043418">
        <property type="term" value="P:homocysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00585">
        <property type="entry name" value="Peptidase_C1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000021">
        <property type="entry name" value="Bleomycin hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004134">
        <property type="entry name" value="Peptidase_C1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363:SF2">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03051">
        <property type="entry name" value="Peptidase_C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005700">
        <property type="entry name" value="PepC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0788">Thiol protease</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="417"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005700-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED19061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="496" mass="55529" checksum="25185FEA9CAEFF5D" modified="2009-03-03" version="1">MGQSPSKLDEKEAAASMSRRSLDKNAYVFVDDDALPPPYEVSDRVSTISLDQTKRWEEKLLSSARNRLAISALSQNPVSAILTNNNAAVADSQIFNIKIPFEGAPITNQRSSGRCWLFASTNVFRVAIMKKYNLKEFELSQSYLFYWDKIEKANWFLEHAIQTAGEDLEGRLVQALFASPVGDGGQWDFVVNLVNKYGLVPQMLYPDSYNAKNSSKMGSLITTKLREQALVLRKLVATGKTDLIAGHKEYFLQEIHSILTIMLGPPPGPDKEFTWTFYDAENKYTKVVTKPTHFASTLSDKQTVRACGGTDVNELFSLVNDPRNDYNRLLTVDRLGNVVGGVPVRYVNVEMKTIKDAAISMLRAGIPVFFGSDVGKFSDSASGIMDTELFDFDLGFNIKLGLTKEQRLKTGESAMTHAMVLTAVHIENGKPVRWRVQNSWGESAGDKGWFVMTDKWMDEFVYQVVVDPRFVSKETRDVLKQDPVVLPLWDPMGALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B8M680</accession>
    <name>B8M680_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_024130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479514.1">
        <property type="nucleotide sequence ID" value="XM_002479469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M680"/>
    <dbReference type="STRING" id="441959.B8M680"/>
    <dbReference type="GeneID" id="8109595"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_024130"/>
    <dbReference type="HOGENOM" id="CLU_2293569_0_0_1"/>
    <dbReference type="InParanoid" id="B8M680"/>
    <dbReference type="OrthoDB" id="2533084at2759"/>
    <dbReference type="PhylomeDB" id="B8M680"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="101" mass="11178" checksum="534D73F3F68870E9" modified="2009-03-03" version="1">MDCQPNCYFLARHKDLTHKHTTTPPQITFAPIILLMGTYLFIALGLPIMQASALATYLEYPTEIGGYGFSSLQTASFTMTAWIGMIAAQVDGYPFNDKIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8M935</accession>
    <name>B8M935_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metal resistance protein ycf1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_111660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481322.1">
        <property type="nucleotide sequence ID" value="XM_002481277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M935"/>
    <dbReference type="STRING" id="441959.B8M935"/>
    <dbReference type="GeneID" id="8098821"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_111660"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1422297_0_0_1"/>
    <dbReference type="InParanoid" id="B8M935"/>
    <dbReference type="OMA" id="MAWFREM"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="PhylomeDB" id="B8M935"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF269">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="154"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED17330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="191" mass="20646" checksum="77BFC001CE7694B9" modified="2009-03-03" version="1">MAQLDPSGTVSDEEIIAALEKVQLWNVIKSRGTGGTSGSNTAAPSGTATPSNDETANGAITPKKAKVDPLEAPLKGSPLSHGQILILDEATGNVDARTNGLMQRIIREEFAKHTILTIAHRLDTIRSVDTILIMDKGKVVKVVTLDELLAKMARKKNAGGGEEEEEEEEEEGEEEEGADMAWFREMWDNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8M945</accession>
    <name>B8M945_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pantothenate transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_111760</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481332.1">
        <property type="nucleotide sequence ID" value="XM_002481287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M945"/>
    <dbReference type="FunCoup" id="B8M945">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="GeneID" id="8098831"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_111760"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_4_2_1"/>
    <dbReference type="InParanoid" id="B8M945"/>
    <dbReference type="OMA" id="GIRIYSY"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="PhylomeDB" id="B8M945"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF43">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="61"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED17340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="503" mass="56851" checksum="B94CC91EC0770146" modified="2009-03-03" version="1">MSAQDDERKSMRNTATTSSESEDGGYPQRLPLSKRILGTIWDSLDKSPEERRLIAKLDWWILSYVCVAYFIKYLDQTNVSNAYVSGMKEDLKLKGNDLNYLTTYWTIGYIIGNLPSQVILTKVRPSIWLPTLEIIWSILVIGMAGAKNVTTIYTLRFFIGLLEASAYPGIMSLLGSWYTPAELGKRSCIFQASSSAAQMFSGYLQAALYKGMNGRSGMSAWQWLFILDGIIGIPIALYGFWAVPDSPTDTRSRWLTAKERELSIERMKNAGHAPPRKLTPRTFFDVGCTWAAWLFSLLFIAHVCGIRIYSYFNVWLKSTGRYSVEQVNLIPTAGFGAQIIFTLSYAWISDALQMRWPIIIFAAIIALIGTIILSVWPANNIPAMMTGWILTFLETGAGALIIAWINEVCAYSREHRMLIIGFVETMAFTFNAWVPLLAYNTSQSPHFKVGYKLAAMFFALEIVLTLLIAYVEKRWNLQKQYLRREESQQGQGEQETHTGVSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8M961</accession>
    <name>B8M961_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_111920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481348.1">
        <property type="nucleotide sequence ID" value="XM_002481303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M961"/>
    <dbReference type="GeneID" id="8098847"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_111920"/>
    <dbReference type="HOGENOM" id="CLU_000680_26_1_1"/>
    <dbReference type="InParanoid" id="B8M961"/>
    <dbReference type="OMA" id="YIGIQAH"/>
    <dbReference type="PhylomeDB" id="B8M961"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="23"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="258" mass="28706" checksum="B824F8EEB07B1A17" modified="2009-03-03" version="1">MLPSTLAAANFTAFQRTIPSLDIVIFSDGSRLIDGRAGGGYIGIQAHYQFLRSSLSYRHGKEVFNIEVEAALADAQAAIAYPTAQFATNLWICLDNLEVIMHLLSPSTGSSQEVFESFHTLAAAWLLRERLPHTKSGSIQIRWVPGHTKISENKVADLAAKEGAISIPPSPYKSSYASLKRYAKTQSLSAAQTRWQTIAPQTYQDLEITTSPKRPRELQLNRLDLDCIIAARTGYGDFADYYKRFNHDDAYLLCQCRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MA04</accession>
    <name>B8MA04_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras modification protein ERF4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_119200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with ERF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482148.1">
        <property type="nucleotide sequence ID" value="XM_002482103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MA04"/>
    <dbReference type="STRING" id="441959.B8MA04"/>
    <dbReference type="GeneID" id="8104370"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119200"/>
    <dbReference type="eggNOG" id="ENOG502S30T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018540_3_1_1"/>
    <dbReference type="InParanoid" id="B8MA04"/>
    <dbReference type="OrthoDB" id="5377273at2759"/>
    <dbReference type="PhylomeDB" id="B8MA04"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031211">
        <property type="term" value="C:endoplasmic reticulum palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051371">
        <property type="entry name" value="Ras_palmitoyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254">
        <property type="entry name" value="GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 7_ERF4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="8">
        <location>
            <begin position="336"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="107"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="203"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="462"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED18156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="493" mass="54630" checksum="55BA395B39C600A4" modified="2009-03-03" version="1">MGVKRLLQTLTKTSPFHTLAQSSSAQPLLSLRSSAPHPRLANIIFNSVSELCSRSPSFSQLSATTASPVGHQSSHNLSPLAAKDDYYYSTDPNSRNILQNNNTTQSSLALPPLLHHPPETHSRSRHEDLPPISPYRHDNTSGKGPGIRVNPSHSGIRLWNPINHVPRVTIVPNRRGLANDEDVGFAIPERDAYPLLSIPSERPQRVAASRNSLVVEPSTGEGAESGRTSIALPSSRHSQQLERSVEQPNMPTTENATKGGHIRPDDGITHPPRHAHSNNSLRASTFASYPSNGGNNTTSAEADGPEEIAWGPAHPCYPHMNPHVPIQSEEFTTTRIIRIRRDWMVKGDLAPTFSNLYPEILDPLLPEQEFRRIIAKVNGELVKAFNPYSLRNWFDSAMGLLTGWLWDEMGFTAIKTHLRQVEDWLEKWNREVGSKDGVRIWSLRRTAYMTLDIQIPDPKVGLVNPEDSSMPGTRPHTGFDAETPTAPAPSHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8MA38</accession>
    <name>B8MA38_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_121110</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482359.1">
        <property type="nucleotide sequence ID" value="XM_002482314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MA38"/>
    <dbReference type="FunCoup" id="B8MA38">
        <property type="interactions" value="334"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MA38"/>
    <dbReference type="GeneID" id="8102450"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_121110"/>
    <dbReference type="eggNOG" id="KOG3996">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8MA38"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="PhylomeDB" id="B8MA38"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF3">
        <property type="entry name" value="HOLOCYTOCHROME-C SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="16"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED18367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="331" mass="37065" checksum="B26D6317BA4461B6" modified="2009-03-03" version="1">MGWFWADTERPAAVPVNNTATTISATPPPGCPMHVAGSSSSGVETPLPSACPVKRSPNSPFYTPSSETTRQQPQEQASANTSGKSKINPLNYMFSFISQERAPTQTVDLPVEREISSIPRADNAGEKWEYPSPQQMYNAMLRKGYTDTPQDAVESMVAVHNFLNEGAWAEIVEWEQIFAKGLKSGWEKCRKGNENLAIELAKERLLCEKKIEDGEELEPCLVRFQGRPQDLSPKARIMQTLGWLYPAKFGTEPPFDRHDWYVSRRTPSGTTKEVRYVIDYYSGPPEPTGEPVFFLDIRPAVDTPTAAVERLMRWGGDVWYRASGGQARENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAF2</accession>
    <name>B8MAF2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_123830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482646.1">
        <property type="nucleotide sequence ID" value="XM_002482601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAF2"/>
    <dbReference type="GeneID" id="8108294"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_123830"/>
    <dbReference type="HOGENOM" id="CLU_2160106_0_0_1"/>
    <dbReference type="InParanoid" id="B8MAF2"/>
    <dbReference type="PhylomeDB" id="B8MAF2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12135" checksum="1AC143CAB3557C7E" modified="2009-03-03" version="1">MADKPADLPAINPLQYAPWHPREPRGNTQAQIGAPMGHTKEQAAANFMAFQRTISSSDIVIFSDGSRLADGRAGDSYIGLQAHHQFLRSSLSYRHRKEVFDTEVEAALAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAM3</accession>
    <name>B8MAM3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_112790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481439.1">
        <property type="nucleotide sequence ID" value="XM_002481394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAM3"/>
    <dbReference type="STRING" id="441959.B8MAM3"/>
    <dbReference type="GeneID" id="8105744"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_112790"/>
    <dbReference type="eggNOG" id="ENOG502SJ8Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004804_0_2_1"/>
    <dbReference type="InParanoid" id="B8MAM3"/>
    <dbReference type="OMA" id="THASMIE"/>
    <dbReference type="OrthoDB" id="5392779at2759"/>
    <dbReference type="PhylomeDB" id="B8MAM3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED17447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="62986" checksum="901433BF1EC523EB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8MB35</accession>
    <name>B8MB35_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_124590</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482728.1">
        <property type="nucleotide sequence ID" value="XM_002482683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MB35"/>
    <dbReference type="FunCoup" id="B8MB35">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MB35"/>
    <dbReference type="GeneID" id="8098410"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_124590"/>
    <dbReference type="eggNOG" id="ENOG502QPSU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030903_0_1_1"/>
    <dbReference type="InParanoid" id="B8MB35"/>
    <dbReference type="OMA" id="DINTGLR"/>
    <dbReference type="OrthoDB" id="4699125at2759"/>
    <dbReference type="PhylomeDB" id="B8MB35"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF18">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, PHENYLALANINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="7">
        <location>
            <begin position="59"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED18736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="376" mass="40636" checksum="4A1C5B903F0AA436" modified="2009-03-03" version="1">MESALFFIDNPNLGNADSLEDHRIRGYNPLTPPNLLQHEIALTEKSKKTVLQGRKDAAAVVKGTDPLNRLLVIIGPCSIHDPEIALEYCDRLLKLKEKYQDTLLIVMRSYLEKPRTTVGWKGLINDPDIDGSFKINKGLRLSRQLFVDLTSKGMPIASEMLDTISPQYTADCLSLGAVGARTTESQVHRELASGLSFPVGFKNGTDGSLGVAIDAIGAVRHPHHFLSVTKPGVVAIVGTDGNDDCFVILRGGTKGTNYDAKSISEAKEDLTKKGLRPRLMVDCSHGNSLKNHKNQPKVADVLAEQIAAGETAIMGVMIESNINEGSQKVPPEGKSGLKYGVSITDACIGWEDTESVLESLAQAVQKRQKLAATNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBL6</accession>
    <name>B8MBL6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Septin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_116690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481872.1">
        <property type="nucleotide sequence ID" value="XM_002481827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBL6"/>
    <dbReference type="FunCoup" id="B8MBL6">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MBL6"/>
    <dbReference type="GeneID" id="8102061"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_116690"/>
    <dbReference type="eggNOG" id="KOG2655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017718_0_0_1"/>
    <dbReference type="InParanoid" id="B8MBL6"/>
    <dbReference type="OMA" id="EASHAEI"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="PhylomeDB" id="B8MBL6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000238">
        <property type="entry name" value="Cell division control 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="27"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="317"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED17880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="382" mass="44006" checksum="9B0ED3FEA1CD5028" modified="2009-03-03" version="1">MATSTETASPIGIANLPNQRHKIVAKRGAAFTIMVAGESGLGKTTFINTLFSTTIKNYADHKKRHAKQIDKTVEIEITKAELEEKFFKVRLTVIDTPGFGDYVNNRDSWQPIIEFLDDQHESYMLQEQQPRRTDKIDLRVHACLYFIRPTGHTLKPLDIEVMKRLSSRVNLIPVIAKADTLSASDLARFKQRVRAVVASQGIQIYQPPVEEDDEHAAAHARSLSAAMPFAVIGSEKDVKNNEGKVVKGRQYAWGVAEVENEDHCDFKKLRSILIRTHMLDLIHTTEESHYEAYRAQQMETRKFGEARPRKLDNPKFKEEEENLRKRFTEQVKVEEQRFRQWEQKLISERDRLNKDLEATHAAIKQLEQELEQMQGSARSGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MC99</accession>
    <name>B8MC99_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Biotin apo-protein ligase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_122760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the biotin--protein ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482537.1">
        <property type="nucleotide sequence ID" value="XM_002482492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MC99"/>
    <dbReference type="FunCoup" id="B8MC99">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MC99"/>
    <dbReference type="GeneID" id="8097741"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_122760"/>
    <dbReference type="eggNOG" id="KOG1536">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006150_1_1_1"/>
    <dbReference type="InParanoid" id="B8MC99"/>
    <dbReference type="OMA" id="HHAFYSN"/>
    <dbReference type="OrthoDB" id="10250105at2759"/>
    <dbReference type="PhylomeDB" id="B8MC99"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin--[biotin carboxyl-carrier protein] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03144">
        <property type="entry name" value="GATase1_ScBLP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019197">
        <property type="entry name" value="Biotin-prot_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835">
        <property type="entry name" value="BIOTIN PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835:SF5">
        <property type="entry name" value="BIOTIN--PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09825">
        <property type="entry name" value="BPL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="395"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED18545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="684" mass="75902" checksum="E4AC70608B84DA74" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCZ3</accession>
    <name>B8MCZ3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TSTA_113450</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="4"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481511.1">
        <property type="nucleotide sequence ID" value="XM_002481466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCZ3"/>
    <dbReference type="STRING" id="441959.B8MCZ3"/>
    <dbReference type="GeneID" id="8101657"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_113450"/>
    <dbReference type="eggNOG" id="ENOG502QTKT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011476_0_0_1"/>
    <dbReference type="InParanoid" id="B8MCZ3"/>
    <dbReference type="OMA" id="QYPDCLK"/>
    <dbReference type="OrthoDB" id="68336at2759"/>
    <dbReference type="PhylomeDB" id="B8MCZ3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000151">
        <property type="entry name" value="Glucan endo-1,3-beta-glucosidase btgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="139"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="366"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EED17519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="730" mass="77420" checksum="2C24DC2250B5081E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8ME02</accession>
    <name>B8ME02_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pirin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_011880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483313.1">
        <property type="nucleotide sequence ID" value="XM_002483268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ME02"/>
    <dbReference type="STRING" id="441959.B8ME02"/>
    <dbReference type="GeneID" id="8104036"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_011880"/>
    <dbReference type="eggNOG" id="ENOG502QQ5A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045717_0_1_1"/>
    <dbReference type="InParanoid" id="B8ME02"/>
    <dbReference type="OMA" id="TPWHPHR"/>
    <dbReference type="OrthoDB" id="198735at2759"/>
    <dbReference type="PhylomeDB" id="B8ME02"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02247">
        <property type="entry name" value="cupin_pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02909">
        <property type="entry name" value="cupin_pirin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903:SF8">
        <property type="entry name" value="PIRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877446" evidence="4">
        <location>
            <begin position="20"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin N-terminal" evidence="5">
        <location>
            <begin position="71"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin C-terminal" evidence="6">
        <location>
            <begin position="225"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006232-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED16079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="353" mass="39469" checksum="951B76BF1E4EFA92" modified="2009-03-03" version="1">MKLFLSILICITAINQVTELLSRVNDNTITTPVTAQDTPHQEQIALPDKMTTARAVRMAFQALEQAEGAGARVRRSIGTPKLRNFSPFLMLDHFTIGKGAGFPDHPHRGQETITYLLSGGVDHEDFAGNRGTIGPGDLQFMTAGKGIMHAEMPHENEDGSPNVGMQLWVDLPKELKYVEPRYRDLRATEIPVAEVDDGRAIIKVISGQSHGVDSVRDLAYTPLWYFDITIKPGGRVKQILPLGWNAFAYTLEGATHFVMDNTDTKPIKQYHNVVFQQSGDYIEAYVPDNAEETSRFILVAGQPLDQEVVQYGPFVCTSKEEVYQAMLDFQSAKNGFERSFGWQSEIGKRMNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8ME96</accession>
    <name>B8ME96_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Ornithine aminotransferase</fullName>
            <ecNumber evidence="4 9">2.6.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_016030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2-oxocarboxylate + L-ornithine = L-glutamate 5-semialdehyde + an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:13877"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="EC" id="2.6.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="4 9"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483757.1">
        <property type="nucleotide sequence ID" value="XM_002483712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ME96"/>
    <dbReference type="FunCoup" id="B8ME96">
        <property type="interactions" value="831"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8ME96"/>
    <dbReference type="GeneID" id="8106376"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_016030"/>
    <dbReference type="eggNOG" id="KOG1402">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_3_1"/>
    <dbReference type="InParanoid" id="B8ME96"/>
    <dbReference type="OMA" id="RSAWDLC"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="PhylomeDB" id="B8ME96"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019544">
        <property type="term" value="P:L-arginine catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010121">
        <property type="term" value="P:L-arginine catabolic process to proline via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006591">
        <property type="term" value="P:ornithine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000011">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000152">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="463" mass="50407" checksum="3B8D8DB39CDA9C97" modified="2009-03-03" version="1">MSPIAIETQNGNVAAEQHDSVYHVASTDAAIAAEHEYAAHNYHPLPIVFARASGTSVWDPEGRHYLDFLSAYSAVNQGHCHPELVKALVDQASRLTLSSRAFYNDVFPKFAEFVTKFFGFDMVLPMCTGAEAVETGIKIARKWGYKVKGIPENQAIVLSVENNFHGRTFAAISMSSDPESRDNYGPYLPNIGHCIPGTNRPIVYNDKVTLREAFEAAGSNLAAFLVEPIQGEAGIVVPDDDYLREARALCDKHNVLLICDEIQTGIARTGKLLCHEWSGIKPDLVLLGKAISGGMYPVSCVLGRKDVMLTVEPGTHGSTYGGNPLGSAIAIRALEVIRDEKMVQNAEKLGHIFRDGLKAINSPLIQTVRGKGLLNAIVIDESKTNGHSAWDLCMLMKSKGLLAKPTHQNIIRLAPPLVITEAEIKSALDVIKQSLEELPTLSGQKEDEVIPPPEKKVKIGVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEG0</accession>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_016640"/>
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        <property type="term" value="P:positive regulation of TORC1 signaling"/>
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    </dbReference>
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        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
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            <begin position="191"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
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            <end position="309"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
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        </location>
    </feature>
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        <location>
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            <end position="1254"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED16587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1297" mass="144332" checksum="03868C4397134758" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEJ5</accession>
    <name>B8MEJ5_TALSN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">TSTA_016980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_016980"/>
    <dbReference type="HOGENOM" id="CLU_000680_26_0_1"/>
    <dbReference type="InParanoid" id="B8MEJ5"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED16622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="242" mass="26645" checksum="4711635504252BAB" modified="2009-03-03" version="1">MGQAADIAIQVVIKKCQTSFSPKSICLNNLEVATRLPSPSTGSSQEVFESFCTLVAAWPLRERLPYTKSSSIQIRWVPGHAKIPENEAADLAAKQGAASTSSPPHKSSYASLKRYAKARALTAAQTLWQSVAPQTYQDLGITTSPKHPGELQLNRLDLGHIIAARTGHGDFADYHKRFNHNNAHLICRCRARKRRASRPPRPPSEVISFLLGTAKGAQRLATWLAETHFFEDICPRQPPLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEQ7</accession>
    <name>B8MEQ7_TALSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_019990</name>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002484129.1"/>
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    <dbReference type="GeneID" id="8108810"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_019990"/>
    <dbReference type="eggNOG" id="ENOG502STMW">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_977203_0_0_1"/>
    <dbReference type="InParanoid" id="B8MEQ7"/>
    <dbReference type="OMA" id="ERREMEF"/>
    <dbReference type="OrthoDB" id="3597048at2759"/>
    <dbReference type="PhylomeDB" id="B8MEQ7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="249" mass="28658" checksum="85F1D28F5B49106E" modified="2009-03-03" version="1">MFQKRALYIPFTILLITATIQLALVSRMVAFLHIQKTEVDSYHVLSNNATDHTANREDFYLHVLPEKLSLNQGHVTNGAAGYGLVLSIASLVANVFLRRDAYKKRHKSILLTITISLSLLVLFTLSALVYVVSVTYLTINNKIDMDVARAVSSKSQPYNIDSWTPETWYRALLLLPLEQDTIESLNSAHHEMVAWRWWVLFYHIVDSLVFWWTGMVLVRVWRKKRDSPSSEELVEYGVGYAGERRESRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEX0</accession>
    <name>B8MEX0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_023070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484487.1">
        <property type="nucleotide sequence ID" value="XM_002484442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEX0"/>
    <dbReference type="GeneID" id="8098336"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_023070"/>
    <dbReference type="HOGENOM" id="CLU_002055_2_0_1"/>
    <dbReference type="InParanoid" id="B8MEX0"/>
    <dbReference type="OrthoDB" id="3562262at2759"/>
    <dbReference type="PhylomeDB" id="B8MEX0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED17253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="136" mass="15431" checksum="2D32C6F074E42968" modified="2009-03-03" version="1" fragment="single">RITRSVLASEMYGMANGFDAAAAIKSTLTQLLHLLEPLPLVLCTDSKSLYECLVKLGTTREKRLMIDLMCLRQSYERQEITEVRWINGNSNPANAMTKSKPCRALQELIDMNKLRIDVDGWVERPSTKRTSESKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MF32</accession>
    <name>B8MF32_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetylornithine aminotransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_012400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483365.1">
        <property type="nucleotide sequence ID" value="XM_002483320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MF32"/>
    <dbReference type="STRING" id="441959.B8MF32"/>
    <dbReference type="GeneID" id="8104088"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_012400"/>
    <dbReference type="eggNOG" id="KOG1401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_1_2_1"/>
    <dbReference type="InParanoid" id="B8MF32"/>
    <dbReference type="OMA" id="RDICDAN"/>
    <dbReference type="OrthoDB" id="425114at2759"/>
    <dbReference type="PhylomeDB" id="B8MF32"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713:SF3">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED16131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="458" mass="50192" checksum="0BB049A255AB0C13" modified="2009-03-03" version="1">MTVADYLAAQLAESHRAYIERNPKSRIAYENSFAYLPGGNTRTVIHADPFPLTFASGEGSTLTSVDGHKYVDLLGEFSAGIFGHSNPRIANAITDAMTRGWNYGGTCTYEKELASKVCERFGPSGLQLVRFTNSGTEANTMAIATAQNVTGKKKILVFSSGYHGGTLVFPLAVMKGETVAPMNLPHDFVYAPYNNISETREILDHLPQDSLAAILVEPIQGSGGCRPADRRFLNFLRTEADERKALLIMDEVMASRLGYSGYSAEMNIRADIMTLGKYLGGGMTIGAFGGRRDIMELFDPTKSKLFHPGTYNNNVFSMAAGITGLDIYDASEVDRLNNLGEKLKTDIQAILMNHGLYPDSYRSPAAGLMEIDSLLTGTEGYIDDHSDKLIQLPSMFVTGRGTASQWQALFYHHMLERNINIAVRGYTPLHLQVSASDCKAYVESIEAFVIKHKAMLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFQ8</accession>
    <name>B8MFQ8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_021090</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484282.1">
        <property type="nucleotide sequence ID" value="XM_002484237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFQ8"/>
    <dbReference type="STRING" id="441959.B8MFQ8"/>
    <dbReference type="GeneID" id="8109366"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_021090"/>
    <dbReference type="eggNOG" id="KOG0556">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_1_1_1"/>
    <dbReference type="InParanoid" id="B8MFQ8"/>
    <dbReference type="OMA" id="EYIVTHA"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="PhylomeDB" id="B8MFQ8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000013">
        <property type="entry name" value="Aspartate--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000132">
        <property type="entry name" value="Aspartyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF2">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="282"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED17048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="946" mass="107452" checksum="51B480B0BB9633B9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>B8MG38</accession>
    <name>B8MG38_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_010230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483139.1">
        <property type="nucleotide sequence ID" value="XM_002483094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MG38"/>
    <dbReference type="GeneID" id="8102819"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_010230"/>
    <dbReference type="HOGENOM" id="CLU_1788110_0_0_1"/>
    <dbReference type="InParanoid" id="B8MG38"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED15905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="145" mass="16007" checksum="5CD6E37EB642C2BD" modified="2009-03-03" version="1">MPSTESVGTIAERKASSFPTFCGNGGGTFCCDSSSCCDESPSPVILTLGRVSTTVFIMNGVLTPDTSKDYYGYQFAAYEITNIDSNREKHWLIHHFDFLTASPTSESNGNTSIVIEQRKTWCRRQSGRMSSMTVTSDSYQIIRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MG42</accession>
    <name>B8MG42_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-dependent oxidoreductase 2 FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_010270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483143.1">
        <property type="nucleotide sequence ID" value="XM_002483098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MG42"/>
    <dbReference type="STRING" id="441959.B8MG42"/>
    <dbReference type="GeneID" id="8105666"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_010270"/>
    <dbReference type="eggNOG" id="KOG2404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011398_4_6_1"/>
    <dbReference type="InParanoid" id="B8MG42"/>
    <dbReference type="OMA" id="WGGMSLK"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="PhylomeDB" id="B8MG42"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006130">
        <property type="entry name" value="PRK08274.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF7">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE 2 FAD BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="5">
        <location>
            <begin position="8"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED15909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="516" mass="55838" checksum="147CE2FC9978ED40" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGB3</accession>
    <name>B8MGB3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_013360</name>
        <name evidence="7" type="ORF">TSTA_022550</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483467.1">
        <property type="nucleotide sequence ID" value="XM_002483422.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484435.1">
        <property type="nucleotide sequence ID" value="XM_002484390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGB3"/>
    <dbReference type="GeneID" id="8107092"/>
    <dbReference type="GeneID" id="8108212"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_013360"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_022550"/>
    <dbReference type="eggNOG" id="ENOG502S2ZX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_4_0_1"/>
    <dbReference type="InParanoid" id="B8MGB3"/>
    <dbReference type="OMA" id="CINATSX"/>
    <dbReference type="OrthoDB" id="4457643at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="60"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED16233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED17201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="548" mass="62706" checksum="51750E1E256FFEDC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGM0</accession>
    <name>B8MGM0_TALSN</name>
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        <recommendedName>
            <fullName evidence="8">C-8 sterol isomerase</fullName>
            <ecNumber evidence="8">5.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Delta-8--delta-7 sterol isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_018420</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ERG2 family.</text>
    </comment>
    <dbReference type="EC" id="5.-.-.-" evidence="8"/>
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        <property type="protein sequence ID" value="EED16771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002483960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGM0"/>
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        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MGM0"/>
    <dbReference type="GeneID" id="8100952"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_018420"/>
    <dbReference type="eggNOG" id="KOG4143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085469_0_0_1"/>
    <dbReference type="InParanoid" id="B8MGM0"/>
    <dbReference type="OMA" id="AMYVIHA"/>
    <dbReference type="OrthoDB" id="347124at2759"/>
    <dbReference type="PhylomeDB" id="B8MGM0"/>
    <dbReference type="UniPathway" id="UPA00768"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006716">
        <property type="entry name" value="ERG2_sigma1_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868">
        <property type="entry name" value="SIGMA 1-TYPE OPIOID RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868:SF1">
        <property type="entry name" value="SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04622">
        <property type="entry name" value="ERG2_Sigma1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED16771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="228" mass="25260" checksum="7467612383E985B0" modified="2009-03-03" version="1">MANAKSASSRGKGTSTLTVLAVVLAAFAALFYYVEQHLDSFYIFDPAHLHDVSQRAIAAHGNDTRAVVKYIVSELDEKLEGKHLNFDEEWVFNNAGGAMGAMYIIHASITEYLIIFGTAIGTEGHTGRHTADDYFHILQGTQLAYVPGSYEPEVYPQGSVHHLRRGDVKQYKMPDSCFALEYARGWIPPMLGFGYADTFTSTLDFPTLWATSRITGREMIGNLLQGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGZ6</accession>
    <name>B8MGZ6_TALSN</name>
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        <submittedName>
            <fullName evidence="4">Chromosome segregation protein Spc105, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_014690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483611.1">
        <property type="nucleotide sequence ID" value="XM_002483566.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B8MGZ6">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MGZ6"/>
    <dbReference type="GeneID" id="8107852"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_014690"/>
    <dbReference type="eggNOG" id="ENOG502S20P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002533_1_0_1"/>
    <dbReference type="InParanoid" id="B8MGZ6"/>
    <dbReference type="OMA" id="WRMKLQE"/>
    <dbReference type="OrthoDB" id="5592879at2759"/>
    <dbReference type="PhylomeDB" id="B8MGZ6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040850">
        <property type="entry name" value="Knl1_RWD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033338">
        <property type="entry name" value="Spc105/Spc7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013253">
        <property type="entry name" value="Spc7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28260">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28260:SF1">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18210">
        <property type="entry name" value="Knl1_RWD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15402">
        <property type="entry name" value="MELT_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08317">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00787">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01315">
        <property type="entry name" value="Spc7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spc7 kinetochore protein" evidence="3">
        <location>
            <begin position="963"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="501"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="593"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="771"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1181"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="598"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="783"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="822"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="836"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="907"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED16377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1514" mass="167629" checksum="2376415CA569FAFA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8MH59</accession>
    <name>B8MH59_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Golgi complex component (Vps8), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_019360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484107.1">
        <property type="nucleotide sequence ID" value="XM_002484062.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B8MH59">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MH59"/>
    <dbReference type="GeneID" id="8104631"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_019360"/>
    <dbReference type="eggNOG" id="KOG2079">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000917_0_0_1"/>
    <dbReference type="InParanoid" id="B8MH59"/>
    <dbReference type="OMA" id="NQLFFHQ"/>
    <dbReference type="OrthoDB" id="289913at2759"/>
    <dbReference type="PhylomeDB" id="B8MH59"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059070">
        <property type="entry name" value="TPR_VPS8_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025941">
        <property type="entry name" value="Vps8_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23410">
        <property type="entry name" value="Beta-prop_VPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12816">
        <property type="entry name" value="TPR_Vps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25066">
        <property type="entry name" value="TPR_VPS8_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 8 central" evidence="2">
        <location>
            <begin position="711"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="domain" description="VPS8-like TPR-like repeats" evidence="3">
        <location>
            <begin position="1235"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1474"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED16873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1585" mass="175435" checksum="A9972A488A2B7997" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MH84</accession>
    <name>B8MH84_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="8">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_019600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484132.1">
        <property type="nucleotide sequence ID" value="XM_002484087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MH84"/>
    <dbReference type="STRING" id="441959.B8MH84"/>
    <dbReference type="GeneID" id="8104655"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_019600"/>
    <dbReference type="eggNOG" id="KOG2431">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1327162_0_0_1"/>
    <dbReference type="InParanoid" id="B8MH84"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="PhylomeDB" id="B8MH84"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF49">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED16898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="207" mass="23404" checksum="A6A4C07581BC0F0C" modified="2009-03-03" version="1">MSTWMLFDSTKIDVFITSSSVAWYEQDGESRSTIEPKAQHLSCFAGGMVALGAKMFEHTEDISVARKLVDGCIWGYDSAPLGIMPEVMYIVACEENEDYPKQSSQYSSYTESPVTQSAQKKAWTMFNNIIQHTVTDIAHAGLDDCTIPHPSEQDRMESFWLAETPKYFYLIFSEPDVGNLGEYVLNTERINYGDLTDRLKVIVVIHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHC8</accession>
    <name>B8MHC8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_021640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484341.1">
        <property type="nucleotide sequence ID" value="XM_002484296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHC8"/>
    <dbReference type="STRING" id="441959.B8MHC8"/>
    <dbReference type="GeneID" id="8098430"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_021640"/>
    <dbReference type="eggNOG" id="ENOG502SHZK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1636545_0_0_1"/>
    <dbReference type="InParanoid" id="B8MHC8"/>
    <dbReference type="OrthoDB" id="189997at2759"/>
    <dbReference type="PhylomeDB" id="B8MHC8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="2">
        <location>
            <begin position="25"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED17107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="162" mass="18359" checksum="C99DD9FB8F56BF5F" modified="2009-03-03" version="1">MISYTRYLIVVQFHSAEVEPEPIDDTSRIEIQMRRRAFWVAYGLDRLACGVLRIPLSIADDNITVPTIATEASLVESANSDAGRIITRITKDAADDIRSKLANVKSMVLNREIIRMVREMITEDLPEDADKTPTEAFQISVKRSIWNLHFQATATVHYHISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHF2</accession>
    <name>B8MHF2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MYB family conidiophore development protein FlbD, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_021880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484365.1">
        <property type="nucleotide sequence ID" value="XM_002484320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHF2"/>
    <dbReference type="STRING" id="441959.B8MHF2"/>
    <dbReference type="GeneID" id="8098454"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_021880"/>
    <dbReference type="eggNOG" id="KOG0048">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046302_1_0_1"/>
    <dbReference type="InParanoid" id="B8MHF2"/>
    <dbReference type="OMA" id="DHNSVCS"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="PhylomeDB" id="B8MHF2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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        </source>
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    </evidence>
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        </source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
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                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485606.1">
        <property type="nucleotide sequence ID" value="XM_002485561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIZ1"/>
    <dbReference type="GeneID" id="8109133"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_050910"/>
    <dbReference type="eggNOG" id="ENOG502SBFH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092474_1_0_1"/>
    <dbReference type="InParanoid" id="B8MIZ1"/>
    <dbReference type="OMA" id="DVKVYRV"/>
    <dbReference type="OrthoDB" id="5366485at2759"/>
    <dbReference type="PhylomeDB" id="B8MIZ1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1460.10">
        <property type="entry name" value="Nuclease A inhibitor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056539">
        <property type="entry name" value="NuiA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42093">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42093:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23151">
        <property type="entry name" value="NuiA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="230" mass="25181" checksum="98A95F64E4246E55" modified="2009-03-03" version="1">MTRFLKHLAKASISLPLTSKTTFPVRSLILRPQRTDLSPQLVSLPTYGIRAMASDSDYMAFLDKANRQRDAGSNEAHTESSTLPSKQVRTETVESGVKVPGPLKKVDAFYVSETDEPFEPVALSWKGASSGKWPENDEFASLIASGSKSDIANSIETLSEKSFDPRNQYSSVIKAVRAAVAASDSTINESDVEVKIYRVEVGHSRVEYWIIALDGAEEKIVGLRAKAIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJJ4</accession>
    <name>B8MJJ4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Threonine dehydratase</fullName>
            <ecNumber evidence="12">4.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Threonine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_046480</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="12"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485147.1">
        <property type="nucleotide sequence ID" value="XM_002485102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJJ4"/>
    <dbReference type="FunCoup" id="B8MJJ4">
        <property type="interactions" value="508"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MJJ4"/>
    <dbReference type="GeneID" id="8099559"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_046480"/>
    <dbReference type="eggNOG" id="KOG1250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021152_6_0_1"/>
    <dbReference type="InParanoid" id="B8MJJ4"/>
    <dbReference type="OMA" id="TRFEYTK"/>
    <dbReference type="OrthoDB" id="4418812at2759"/>
    <dbReference type="PhylomeDB" id="B8MJJ4"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04906">
        <property type="entry name" value="ACT_ThrD-I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04907">
        <property type="entry name" value="ACT_ThrD-I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1020.10:FF:000001">
        <property type="entry name" value="L-threonine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000008">
        <property type="entry name" value="L-threonine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1020.10">
        <property type="entry name" value="Biosynthetic Threonine Deaminase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001721">
        <property type="entry name" value="TD_ACT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038110">
        <property type="entry name" value="TD_ACT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005787">
        <property type="entry name" value="Thr_deHydtase_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01124">
        <property type="entry name" value="ilvA_2Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006674">
        <property type="entry name" value="PRK09224.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF11">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00585">
        <property type="entry name" value="Thr_dehydrat_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51672">
        <property type="entry name" value="ACT_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 12" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="10 12 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACT-like" evidence="14">
        <location>
            <begin position="384"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="ACT-like" evidence="14">
        <location>
            <begin position="480"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED15194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="562" mass="61415" checksum="09D985DF1543AC7F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKI4</accession>
    <name>B8MKI4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CREG-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_047850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485292.1">
        <property type="nucleotide sequence ID" value="XM_002485247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKI4"/>
    <dbReference type="STRING" id="441959.B8MKI4"/>
    <dbReference type="GeneID" id="8099335"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_047850"/>
    <dbReference type="eggNOG" id="ENOG502RDU8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_700395_0_0_1"/>
    <dbReference type="InParanoid" id="B8MKI4"/>
    <dbReference type="OMA" id="LSIDWWH"/>
    <dbReference type="OrthoDB" id="2138282at2759"/>
    <dbReference type="PhylomeDB" id="B8MKI4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055343">
        <property type="entry name" value="CREG_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273:SF1">
        <property type="entry name" value="ADL397C-AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13883">
        <property type="entry name" value="CREG_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877655" description="CREG-like beta-barrel domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="CREG-like beta-barrel" evidence="2">
        <location>
            <begin position="150"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED15339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="364" mass="39702" checksum="9E9CB8BC441676C2" modified="2009-03-03" version="1">MAQGHLNILTLLSAAILCLYLPSVLGTPFIVTPRREDGLHQQKDQTALLQHVGYQGNSNNAGRDDPLKDFISDVVHDSVVPVAPPASIPLPSPPMMSSLRYAGNVDGLDNITIGLHRIADGEELDGDEETAADDEEELSTLRRPSWFDSVLLARRLLAKSSIGIASTVYQHTDSSSSAHLTGLEGVPISLPEYIADCSEIIDSNNNNGNPILLGLYVSTTFRNIAKGSNISLSIDWWNHLNDTKPVYPGFPLSEAGLPRISLIGYVERLDLSSTEKIKDGLEECFFAIHPDAKVWAPGNPDSPHSGFWARMVVTRVYWIGGFGDLQQIGWINMTDWRGVGRYESASSIGDGSGRGWEDIRLPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLL9</accession>
    <name>B8MLL9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acyl-CoA thioesterase II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_049900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485505.1">
        <property type="nucleotide sequence ID" value="XM_002485460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLL9"/>
    <dbReference type="STRING" id="441959.B8MLL9"/>
    <dbReference type="GeneID" id="8108754"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_049900"/>
    <dbReference type="eggNOG" id="KOG3016">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064147_0_0_1"/>
    <dbReference type="InParanoid" id="B8MLL9"/>
    <dbReference type="OMA" id="IPPETEC"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="PhylomeDB" id="B8MLL9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF35">
        <property type="entry name" value="ACYL-COA THIOESTERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="3">
        <location>
            <begin position="28"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="4">
        <location>
            <begin position="175"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED15552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="32552" checksum="B6D3BB1A1D8D8B97" modified="2009-03-03" version="1">MSTLSDQLAVEHISPGCYRSVLPPIRMGDWASFAFGGNTLSVAVNSAYQTVEPSHHLYSICGHFVHAADTDRRLICEVESLKNTRSFQTRHIRVFQEINNGVRQLCLIASADFHILEPRSMVVYSTSPWTPNVQPTEHGLYSHIERLVEIKPIAIAANAGMEFGNQDSTSDPSSPSLKISAENFKIRGTLNTEAERITALAFYMDKGLAYIPASHSGYSLINASACTTLDFSLRLFTHEVDLRDWHLLESRTAVAGNARAFSEGRVWNGKGRLLASMTQQTLLRPRKGFSPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMB0</accession>
    <name>B8MMB0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fatty-acid amide hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_099170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485902.1">
        <property type="nucleotide sequence ID" value="XM_002485857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMB0"/>
    <dbReference type="STRING" id="441959.B8MMB0"/>
    <dbReference type="GeneID" id="8103995"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_099170"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="InParanoid" id="B8MMB0"/>
    <dbReference type="OMA" id="NNIPLEW"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="PhylomeDB" id="B8MMB0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF11">
        <property type="entry name" value="AMIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="3">
        <location>
            <begin position="80"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED13664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="386" mass="43098" checksum="1D9C8F1621151ECB" modified="2009-03-03" version="1">MTQTTWQKVEIKIFQAKNNIPLEWRLPSSYLEVLQDACQSVLGIPHRCGILSEMEIHVTEAFDETALFEKPASRGLTAVEVTTAFCKRAAIAHQLTYCLTETFFDTALRRARELDDHLEATGKTTGPLHGLPISVKECYNIAVGFKPSASQVPYGNIGSAARLEMARFLPCAGSLSHTVRDVELLLRVVLNSNAADLDDNALGVPWNATRQRPSLRAGVLPEDALYRLASSNAACSEKCSDQHFKADVIHLRGKDLAFRFFNMNPDRTALSHVKNGDEPFIPSLKSTYDLDKNAPEPQLLELYQLNVSKAKLLTRMRQVFVENKVDPVSYHSEGQMHLKTPNLSETFRTRRSEVEGAPCHIQLTGKPMRDEDLIQDALIVEKVLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMB2</accession>
    <name>B8MMB2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C6 transcription factor (Leu3), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_099190</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485904.1">
        <property type="nucleotide sequence ID" value="XM_002485859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMB2"/>
    <dbReference type="GeneID" id="8103997"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_099190"/>
    <dbReference type="eggNOG" id="ENOG502QPVP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011455_2_0_1"/>
    <dbReference type="InParanoid" id="B8MMB2"/>
    <dbReference type="OMA" id="ILDAVWW"/>
    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="PhylomeDB" id="B8MMB2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000003">
        <property type="entry name" value="C6 transcription factor (Leu3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF21">
        <property type="entry name" value="REGULATORY PROTEIN LEU3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED13666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="657" mass="73906" checksum="F2FE65932F000130" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMB5</accession>
    <name>B8MMB5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_099220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 54 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485907.1">
        <property type="nucleotide sequence ID" value="XM_002485862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMB5"/>
    <dbReference type="STRING" id="441959.B8MMB5"/>
    <dbReference type="GeneID" id="8104000"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_099220"/>
    <dbReference type="eggNOG" id="ENOG502QS3Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029332_0_0_1"/>
    <dbReference type="InParanoid" id="B8MMB5"/>
    <dbReference type="OMA" id="QPTRYWR"/>
    <dbReference type="OrthoDB" id="157622at2759"/>
    <dbReference type="PhylomeDB" id="B8MMB5"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000131">
        <property type="entry name" value="Probable alpha-L-arabinofuranosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015289">
        <property type="entry name" value="A-L-arabinofuranosidase_B_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038964">
        <property type="entry name" value="ABFB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39447">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39447:SF2">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09206">
        <property type="entry name" value="ArabFuran-catal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027143015" description="Alpha-L-arabinofuranosidase" evidence="4">
        <location>
            <begin position="27"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="6">
        <location>
            <begin position="360"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="89"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="184"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR638964-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR638964-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED13669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="419" mass="42832" checksum="7427CC3F5A69D4C4" modified="2009-03-03" version="1">MSLGHSFKRAGLFSLCLIATGTLVTAGPCDIYSSGGTPCVAAHSSTRALYSSYSGPLYQVKRNSDSATTNISPVSAGGIANAAAQDSFCSGTTCLISIIYDQSGHGNHLTAAPPGGFSGPGPNGYDNLANAAAAPVYLGGQKVYGVYIAPGDGYRNNAANGTATGDGAEGLYAIFDGTHYNGGCCFDYGNAETSSRDTGAGHMEAIYFGNCNVWGTGSGNGPWIMADLENGLFSGASAGKNTGDPSISYRFVTAVVKGEANQWAIRGGNSQSGSLSTFYSGGRPSGYNPMHKEGAIILGIGGDNSHGAEGTFYEGVMTSGYPSDATENSVQANIVAAKYGTSASSGTTTTGTGTQPSSGSGQVHWGQCGGSGWTGPTSCEAPYACQTQNPYYAQFDGFPWETREYLGILSVALQRRVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMJ3</accession>
    <name>B8MMJ3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MYB DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_099950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485985.1">
        <property type="nucleotide sequence ID" value="XM_002485940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMJ3"/>
    <dbReference type="STRING" id="441959.B8MMJ3"/>
    <dbReference type="GeneID" id="8105438"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_099950"/>
    <dbReference type="eggNOG" id="ENOG502SP4F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013658_0_0_1"/>
    <dbReference type="InParanoid" id="B8MMJ3"/>
    <dbReference type="OMA" id="KANCARF"/>
    <dbReference type="OrthoDB" id="5398572at2759"/>
    <dbReference type="PhylomeDB" id="B8MMJ3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11671">
        <property type="entry name" value="TAZ1_RBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="693"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="693"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED13747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="799" mass="88590" checksum="CDF27A3E3B29EAA3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8MN01</accession>
    <name>B8MN01_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_101860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486188.1">
        <property type="nucleotide sequence ID" value="XM_002486143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MN01"/>
    <dbReference type="STRING" id="441959.B8MN01"/>
    <dbReference type="GeneID" id="8099231"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_101860"/>
    <dbReference type="eggNOG" id="ENOG502QQMC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1611912_0_0_1"/>
    <dbReference type="InParanoid" id="B8MN01"/>
    <dbReference type="OMA" id="ECGSIRI"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="PhylomeDB" id="B8MN01"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED13950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="19247" checksum="DA59658B3BBA18F0" modified="2009-03-03" version="1">MEDKILSRSCNYIEWTNIPRISQCDEQEQDRLDLLHKAITEARIGDGLLYAPHHSNARVLDLGCGTRVWAVDVANKYPEAFVIGVDLTKIQPPNRPRNCDFYAPHDFEDQWTLGEDQWDVIYMQMGCGSVSSWSSLYRRVFMRFQSIHPKTEDDPSWKLNEAYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNK5</accession>
    <name>B8MNK5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_103200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486332.1">
        <property type="nucleotide sequence ID" value="XM_002486287.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486334.1">
        <property type="nucleotide sequence ID" value="XM_002486289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNK5"/>
    <dbReference type="GeneID" id="8103023"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_103200"/>
    <dbReference type="InParanoid" id="B8MNK5"/>
    <dbReference type="OrthoDB" id="4225519at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010871">
        <property type="entry name" value="DUF1502"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07397">
        <property type="entry name" value="DUF1502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED14094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="177" mass="19671" checksum="6F3A2B54F7A7952E" modified="2009-03-03" version="1">MALSASAIIVIVVCVSALFVTILWTFSGYYGRASTMDEAKTQISHEQDTYMRQVRQRNHEYAYAESIFGSGGASTTRTSQVWSNTNNGSTPNTPMATRGAGTPAWGAKRMDSNGKQSLSQSSMNVQQGKDGSRVNYSTYEPAEYFEQSPYESNEYYYGYEQTQQANERVNQVPSEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNW4</accession>
    <name>B8MNW4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">enoyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="11">1.3.1.104</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_104230</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.104"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.104" evidence="11"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486441.1">
        <property type="nucleotide sequence ID" value="XM_002486396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNW4"/>
    <dbReference type="FunCoup" id="B8MNW4">
        <property type="interactions" value="714"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MNW4"/>
    <dbReference type="GeneID" id="8103194"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_104230"/>
    <dbReference type="eggNOG" id="KOG0025">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_17_0_1"/>
    <dbReference type="InParanoid" id="B8MNW4"/>
    <dbReference type="OMA" id="YGYTQSK"/>
    <dbReference type="OrthoDB" id="7482721at2759"/>
    <dbReference type="PhylomeDB" id="B8MNW4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000112">
        <property type="entry name" value="Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000029">
        <property type="entry name" value="Mitochondrial enoyl reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="71"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED14203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="420" mass="46314" checksum="C4C684EE43EF92C7" modified="2009-03-03" version="1">MFTPRTLRPSAPCIRQATSSYRSSIESVRAPFIRSKVQGGYQAGAAAQRFVSAYGYTQAKVIVYPKYGEPKDVLQLHKHSIGPPSGSQVNLRLLATPLNPADINQIQGVYPAKPTFTNILGTTEPSAVAGNEGAFEVLSTGPQVQSLKKGDWVIMKRTGQGTWRTHAQLEESQLIKVDKEGLTALQVGTVSVNPVTAYRMIKDFCDWDWMRSGEEWLIQNGANSGVGRAAIQLARVWGIKTLNVIRQRENPEETEALKKDLLDLGATAVVTEEELLSKEFRGIVKQLTKDGKEPIRLALNCVGGENAAAMAKVLAPDSHLVTYGAMSRKPVALPSGLLIFKNLVFDGFWVSRWGDKNSQAKENTIKDIFELTRAGKFKDIPVQEVKWTYDKEPKELVEAVQDTLSGFRSGKTIFVYEGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPC8</accession>
    <name>B8MPC8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alcohol dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_105780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486605.1">
        <property type="nucleotide sequence ID" value="XM_002486560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPC8"/>
    <dbReference type="FunCoup" id="B8MPC8">
        <property type="interactions" value="278"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MPC8"/>
    <dbReference type="GeneID" id="8100437"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_105780"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_1_1"/>
    <dbReference type="InParanoid" id="B8MPC8"/>
    <dbReference type="OMA" id="QFPIRSH"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="PhylomeDB" id="B8MPC8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF6">
        <property type="entry name" value="TRANS-ENOYL REDUCTASE APDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="22"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED14367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="363" mass="39124" checksum="9EAD04C2C62ED177" modified="2009-03-03" version="1">MAIQLTQSLPAFQKAYKVRGAGDASLETSVSVPEPKDDQLLVRVVAVGLNPHDWKSLDMSPMPGATWGCDFSGEVVKTGSGLAKNFRVGDRVAGATPGNNWEDPTTGAFAEYVVAPCALVYKIPESMGFEEAATLGVGMLTIGLTLYHAMKLPLPHAPVENPQYVLVYGGGTATGTLAIQALRLSGMIPLTTCSPSRFDQVKALGAKEAWDYHSPSCGSDIRAYTDDKLVYALDCITDTGSMKVCYAAIGSGGGQYVALDQFPIRGHTRRNVKPDWVITWTLLGKPVHWKKPYRRDARPKDKAFGDKWIPMSQNLLDSGDIKTHSIEVSDDGLAGILAGVDRLRKGTTGGKKLIYRINQPLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPI6</accession>
    <name>B8MPI6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Kinesin light chain, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_106340</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the kinesin light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486663.1">
        <property type="nucleotide sequence ID" value="XM_002486618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPI6"/>
    <dbReference type="STRING" id="441959.B8MPI6"/>
    <dbReference type="GeneID" id="8098886"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_106340"/>
    <dbReference type="eggNOG" id="KOG1840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_125_15_1"/>
    <dbReference type="InParanoid" id="B8MPI6"/>
    <dbReference type="OMA" id="LMARHMF"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="PhylomeDB" id="B8MPI6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002151">
        <property type="entry name" value="Kinesin_light"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45783">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45783:SF3">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="19"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED14425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="339" mass="39172" checksum="962C9DA438C342FD" modified="2009-03-03" version="1">MYRRALDENTLGSDHASTLLIVNNFGNLYADQNKLKEAEKMFRRALEGYENTLGPDHKSTLNSVYYLGILYQKQDKQKEAEKMYRRALAGYEKALCSSHTKIQRVRKRLNTLMISSERYNVNLAKVSTEVTLWELKKFIAQLTINLPLVPLTLYLYASGHPKKFLRLDRQGIPRDLVRDDDQDIQDFHDALAPPISYSLIRVEMDERLFDMHRLVQLSVRAWLETSSGSLRRGLSDVLTGLERTQGKYERRKTMHRRALEARERVLGPEHPDTLTSVSNLGLVLYRQGKYEEAEAMHRRALEALERVLGHAHPDMVASINVPLDSNQREKHEEASVIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPT8</accession>
    <name>B8MPT8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NRPS-like enzyme, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_052670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486857.1">
        <property type="nucleotide sequence ID" value="XM_002486812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPT8"/>
    <dbReference type="STRING" id="441959.B8MPT8"/>
    <dbReference type="GeneID" id="8098216"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_052670"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002220_2_1_1"/>
    <dbReference type="InParanoid" id="B8MPT8"/>
    <dbReference type="OMA" id="FPRSDKG"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="PhylomeDB" id="B8MPT8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="108"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="4">
        <location>
            <begin position="704"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED12746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1089" mass="121910" checksum="874E099466857A13" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQ93</accession>
    <name>B8MQ93_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_057310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487351.1">
        <property type="nucleotide sequence ID" value="XM_002487306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQ93"/>
    <dbReference type="GeneID" id="8108867"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_057310"/>
    <dbReference type="HOGENOM" id="CLU_2122725_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQ93"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877640" description="Secreted protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED13240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="11652" checksum="05D58A120CD1B06B" modified="2009-03-03" version="1">MVKANDTIAIIIALFLTITIVGSTLACRTVTDTDTEKGTTSDDHGGGPGDAEASIGQQSQPVQVIRVPQQPAQGSSVRAPGNVVGDRGVVVPGRVGQDGGVRVVRHPQTAQVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQI1</accession>
    <name>B8MQI1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcription factor (Sin3), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_058720</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487494.1">
        <property type="nucleotide sequence ID" value="XM_002487449.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B8MQI1">
        <property type="interactions" value="1114"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MQI1"/>
    <dbReference type="GeneID" id="8106474"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_058720"/>
    <dbReference type="eggNOG" id="KOG4204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001360_2_4_1"/>
    <dbReference type="InParanoid" id="B8MQI1"/>
    <dbReference type="OMA" id="MCEEVIK"/>
    <dbReference type="OrthoDB" id="10265969at2759"/>
    <dbReference type="PhylomeDB" id="B8MQI1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000001">
        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000002">
        <property type="entry name" value="Paired amphipathic helix protein SIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000003">
        <property type="entry name" value="Paired amphipathic helix SIN3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF0">
        <property type="entry name" value="SIN3A, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="9">
        <location>
            <begin position="810"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="182"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="342"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="579"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1100"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1551"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="93"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="431"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="579"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1582"/>
            <end position="1594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED13383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1602" mass="179864" checksum="4283A1E6F18EBE7A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRH4</accession>
    <name>B8MRH4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_056100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487222.1">
        <property type="nucleotide sequence ID" value="XM_002487177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRH4"/>
    <dbReference type="GeneID" id="8100675"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_056100"/>
    <dbReference type="eggNOG" id="ENOG502SC0A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1876825_0_0_1"/>
    <dbReference type="InParanoid" id="B8MRH4"/>
    <dbReference type="OrthoDB" id="3358750at2759"/>
    <dbReference type="PhylomeDB" id="B8MRH4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39475">
        <property type="entry name" value="CONIDIATION-SPECIFIC PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39475:SF1">
        <property type="entry name" value="CONIDIATION-SPECIFIC PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="136" mass="15095" checksum="844A81D8F2CD3DDC" modified="2009-03-03" version="1">MASVGTSGSANHSYKATATSGSGASNVGSRQIYEAGDQRNPSQSEIRERERYKEGQSGSHLANDSKDERSIANRLGREEQRSRKDERPYDPEAELSKKDPTAPVCRLLKLSDMRIQLTCNPPGHTARQQPLERRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRL6</accession>
    <name>B8MRL6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_056730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487284.1">
        <property type="nucleotide sequence ID" value="XM_002487239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRL6"/>
    <dbReference type="STRING" id="441959.B8MRL6"/>
    <dbReference type="GeneID" id="8100736"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_056730"/>
    <dbReference type="eggNOG" id="ENOG502RAX7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008220_0_0_1"/>
    <dbReference type="InParanoid" id="B8MRL6"/>
    <dbReference type="OMA" id="LIAVWPM"/>
    <dbReference type="OrthoDB" id="38531at2759"/>
    <dbReference type="PhylomeDB" id="B8MRL6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057688">
        <property type="entry name" value="DUF7928"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF2">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25550">
        <property type="entry name" value="DUF7928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="700"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="734"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="773"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="827"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="854"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7928" evidence="3">
        <location>
            <begin position="36"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="2">
        <location>
            <begin position="503"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED13173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="884" mass="98881" checksum="FF3DB1CDCFE76118" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MT19</accession>
    <name>B8MT19_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-containing alcohol dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_001700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487753.1">
        <property type="nucleotide sequence ID" value="XM_002487708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MT19"/>
    <dbReference type="STRING" id="441959.B8MT19"/>
    <dbReference type="GeneID" id="8098664"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_001700"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_1"/>
    <dbReference type="InParanoid" id="B8MT19"/>
    <dbReference type="OMA" id="AKCWNYV"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="PhylomeDB" id="B8MT19"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05289">
        <property type="entry name" value="MDR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052585">
        <property type="entry name" value="Lipid_raft_assoc_Zn_ADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482:SF4">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482">
        <property type="entry name" value="PROTEIN AST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="69"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="392" mass="42724" checksum="4844A1CAABB8CBB2" modified="2009-03-03" version="1">MRDFTVVIKPKSKSPLERMPWGGATSRVALFSINSPLARLWRKIPPTMQAVRLHPAPASSPAYSPLNPAPSSALHLDKDLPIPKPSKPGELLVRVRAATVVRDMLTWPETYAHDYPILGNDLSGVVVETFSQQSSFKPGDEIFGMTDGERPCTWAEYCIVMEDEVALKPKGLTWDAAAAMPLSAQTAYEALYDHAGISVPVLGDNFRPGGRRSLTSEHKQRLLITGAAGAVGIYLVQLASISDLYTVAATSSNARNKEFLQTLGADETVEYSALLGGNKKSFDVIVDTVGGSTLLGCWENIKEGGTIISVDSASYDFVADHQKRSLSKEGINALFFIVKGGKRSLEFLARLAELDILRPFVLQTYPLSEVRQAYDHTNGRYSGRGKVILTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MT64</accession>
    <name>B8MT64_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="3">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_002280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="3"/>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487815.1">
        <property type="nucleotide sequence ID" value="XM_002487770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MT64"/>
    <dbReference type="STRING" id="441959.B8MT64"/>
    <dbReference type="GeneID" id="8102839"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_002280"/>
    <dbReference type="eggNOG" id="KOG3822">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019942_1_1_1"/>
    <dbReference type="InParanoid" id="B8MT64"/>
    <dbReference type="OMA" id="GMGPHPT"/>
    <dbReference type="OrthoDB" id="1933379at2759"/>
    <dbReference type="PhylomeDB" id="B8MT64"/>
    <dbReference type="UniPathway" id="UPA00929">
        <property type="reaction ID" value="UER00894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000001">
        <property type="entry name" value="Succinyl-coa:3-ketoacid-coenzyme a transferase subunit b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF60">
        <property type="entry name" value="ACETATE COA-TRANSFERASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="4">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED12161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="551" mass="59069" checksum="31B48DB093F150A5" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTX2</accession>
    <name>B8MTX2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_006150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488240.1">
        <property type="nucleotide sequence ID" value="XM_002488195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTX2"/>
    <dbReference type="GeneID" id="8105300"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_006150"/>
    <dbReference type="eggNOG" id="ENOG502S6P7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013452_0_0_1"/>
    <dbReference type="InParanoid" id="B8MTX2"/>
    <dbReference type="OMA" id="AGTHYAW"/>
    <dbReference type="OrthoDB" id="545169at2759"/>
    <dbReference type="PhylomeDB" id="B8MTX2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="61703" checksum="53E5B564B3F972A3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUI5</accession>
    <name>B8MUI5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_108400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488409.1">
        <property type="nucleotide sequence ID" value="XM_002488364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUI5"/>
    <dbReference type="STRING" id="441959.B8MUI5"/>
    <dbReference type="GeneID" id="8103014"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_108400"/>
    <dbReference type="eggNOG" id="ENOG502SK65">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025457_3_0_1"/>
    <dbReference type="InParanoid" id="B8MUI5"/>
    <dbReference type="OMA" id="TICEAMD"/>
    <dbReference type="OrthoDB" id="4225927at2759"/>
    <dbReference type="PhylomeDB" id="B8MUI5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057684">
        <property type="entry name" value="DUF7924"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42470:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42470">
        <property type="entry name" value="VAST DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25545">
        <property type="entry name" value="DUF7924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7924" evidence="2">
        <location>
            <begin position="157"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED11653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="495" mass="57443" checksum="0864900A30A1147E" modified="2009-03-03" version="1">MKRTIASDSYDDVGERPAKKLRRRDSSSTVAVPSNKEQEQITTQPLSPLSYNKINEQERGQSAIVHPSKPINKAWIPAPSEQFNEVDVMSQPASKRSRSQSTSTDRGRPRSVSPTGSGKLCDDSRDKRLLYAPFPRRSDFRSESVEIPRGLFDDEFIEDFHNTLRNRSEARLLVDLHPLLMPSAENLFIQGKDELKNVIDGYNDPWLKTEPIYGPKPQPDHARGLRWSTFSDNQRRKLGIKPGEKSLYAVREDMYFPYLTAEIKCGNQALEFADRQNMHSMCIALRAVVSLAEAAGRLGEVNRRLLGFSISHELEGVRIYGHYPEIGEDGIKYYRWLVKQFNIWADGDKWQCLRFVENLDRDFLPIHTGRLMRFLEEVPDPQELPFELESQERSSYSRAPSAQNRVLQPELRSMIQTLQQQLEEQKFQQEQLSADQKAREEKLLAQLEQQREEQKTREAEQKAREAEQKAREEKLLAQLEQQQERLFKLLEQKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUY6</accession>
    <name>B8MUY6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_110070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488583.1">
        <property type="nucleotide sequence ID" value="XM_002488538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUY6"/>
    <dbReference type="GeneID" id="8107239"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_110070"/>
    <dbReference type="HOGENOM" id="CLU_2672798_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUY6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="75" mass="7810" checksum="69B3ED085273B0A1" modified="2009-03-03" version="1">MPVATRAAVGRSATRTPDLDNPPSSSPEIQRSKSAMLQGNTAAKPANPNPNANATEIGAQMIINLINSLKKAITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MVC9</accession>
    <name>B8MVC9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SEC14 cytosolic factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_007790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962663">
        <property type="protein sequence ID" value="EED11489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488805.1">
        <property type="nucleotide sequence ID" value="XM_002488760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MVC9"/>
    <dbReference type="STRING" id="441959.B8MVC9"/>
    <dbReference type="GeneID" id="8103453"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_007790"/>
    <dbReference type="eggNOG" id="KOG1471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014001_4_0_1"/>
    <dbReference type="InParanoid" id="B8MVC9"/>
    <dbReference type="OMA" id="CWIYSKS"/>
    <dbReference type="OrthoDB" id="30289at2759"/>
    <dbReference type="PhylomeDB" id="B8MVC9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF20">
        <property type="entry name" value="CRAL_TRIO DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G00680)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="89"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="382" mass="43337" checksum="3B43329490703F4C" modified="2009-03-03" version="1">MAIQTEIFYNLAEQHLSALETFWKLCDEGGLLARPAGLSENEAQDGLNDETTLLRYLRARRFDPHQSLKQFQQATITHRNNRIPIQYNEIDVLEFETARFLYPHWSGRRTKKGLPICLFDFGHLNRSTLAAYEKTRVTSLGKDTSMTATQRASIAHDYLTRFVFPLCSVMKDRPRPSVPITSAIYLVDLSAFTMKQGWDIKNYTSDIGQLLMMGYPEIIDRLFVLNAPLYFGWMWGIMRKWLDPGTVDKVVIVPASEMMPTLAKYIDAESIPSRFGGEFAWEHGTPLDLDVRIQSGLEWKDEGKLPPGPMKWVLDESGRKTAVAVGSIEGVARTTRIAQVKVEDEAIRVGDPEKNIRMTGLKRTGDMAIATLPFRDENNGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8MVD6</accession>
    <name>B8MVD6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_007860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962663">
        <property type="protein sequence ID" value="EED11496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488812.1">
        <property type="nucleotide sequence ID" value="XM_002488767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MVD6"/>
    <dbReference type="STRING" id="441959.B8MVD6"/>
    <dbReference type="GeneID" id="8103460"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_007860"/>
    <dbReference type="HOGENOM" id="CLU_433592_0_0_1"/>
    <dbReference type="InParanoid" id="B8MVD6"/>
    <dbReference type="OrthoDB" id="4369352at2759"/>
    <dbReference type="PhylomeDB" id="B8MVD6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="484"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="555"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="506"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED11496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="631" mass="72133" checksum="CA7ADEE85E99C2A5" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8LT06</accession>
    <name>B8LT06_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_064680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340389.1">
        <property type="nucleotide sequence ID" value="XM_002340348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LT06"/>
    <dbReference type="GeneID" id="8102383"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_064680"/>
    <dbReference type="eggNOG" id="ENOG502QR0D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1107728_0_0_1"/>
    <dbReference type="InParanoid" id="B8LT06"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="PhylomeDB" id="B8LT06"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED23002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="232" mass="26806" checksum="A905BFE163D5D19F" modified="2009-03-03" version="1">MDPHSYSPHQRRWERRLSRDVNEALPIETYLYRCDPYRSSTVQHPWPYGVKVTQELAMRELILAYKNDIRDTFIRHGFPSDGSGVKLNFTVKRVFPADQRPSTVLSIGIENDPIPTRDLSIVRDAVYLLLLDKRLKTMHVDIFDCDRRFMPFKAQEDIVRLLRDKDNLSWQAICLYQVGRCLDQAVPCIVVSVPPGTIYNWASLRNEILDALGSDIEVEFLPVVPKLTDSCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8LT70</accession>
    <name>B8LT70_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Shikimate 5-dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_069920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340965.1">
        <property type="nucleotide sequence ID" value="XM_002340924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LT70"/>
    <dbReference type="STRING" id="441959.B8LT70"/>
    <dbReference type="GeneID" id="8107359"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_069920"/>
    <dbReference type="eggNOG" id="KOG0692">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044063_1_0_1"/>
    <dbReference type="InParanoid" id="B8LT70"/>
    <dbReference type="OMA" id="VFLDMCY"/>
    <dbReference type="OrthoDB" id="204377at2759"/>
    <dbReference type="PhylomeDB" id="B8LT70"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089:SF26">
        <property type="entry name" value="AROM POLYPEPTIDE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="SHIKIMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="311" mass="34995" checksum="5A604A2D7C280B81" modified="2009-03-03" version="1">MPDQKRIYFIGSNISHAITNTIHNDVAATIGYTNWRLEAIDIPDVTHDDTLIKGKLHGPKFAGAVITMPHKLAIIRYLDDVDEIVSLVGACNNIYPVIAGTESKLIGTNTDWIGIRECLLRLDRESRPNNAINDEETKSGFIVGAGGASRAAIYALTRHLSVARIYIVNRDIDEVQTLVNDIKTRYQSRRTPIPEIIHLQTPEQARNINHFPYYGIGTVPDYPPTTDEEITARDTLHSLLARGNSEGGRRAVFLDMCYKPRQTRNLVAAKMYGWVTGEGVDVVTYQLKEQWRLWAGEEEMARRARQIADLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B8LT76</accession>
    <name>B8LT76_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Actin cortical patch component, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_069980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat AIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340971.1">
        <property type="nucleotide sequence ID" value="XM_002340930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LT76"/>
    <dbReference type="FunCoup" id="B8LT76">
        <property type="interactions" value="775"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LT76"/>
    <dbReference type="GeneID" id="8101223"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_069980"/>
    <dbReference type="eggNOG" id="KOG0318">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015246_1_0_1"/>
    <dbReference type="InParanoid" id="B8LT76"/>
    <dbReference type="OMA" id="FYQGPPF"/>
    <dbReference type="OrthoDB" id="2306at2759"/>
    <dbReference type="PhylomeDB" id="B8LT76"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003786">
        <property type="term" value="F:actin lateral binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032466">
        <property type="term" value="P:negative regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000102">
        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000167">
        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856">
        <property type="entry name" value="WD-REPEATCONTAINING PROTEIN WDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="185"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="229"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="6">
        <location>
            <begin position="488"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="489"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="532"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="575"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED23584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="612" mass="65333" checksum="7BC2053D7FA011C1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTD4</accession>
    <name>B8LTD4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_064780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340399.1">
        <property type="nucleotide sequence ID" value="XM_002340358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTD4"/>
    <dbReference type="STRING" id="441959.B8LTD4"/>
    <dbReference type="GeneID" id="8109482"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_064780"/>
    <dbReference type="eggNOG" id="ENOG502S7ZF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_909665_0_0_1"/>
    <dbReference type="InParanoid" id="B8LTD4"/>
    <dbReference type="OrthoDB" id="2744543at2759"/>
    <dbReference type="PhylomeDB" id="B8LTD4"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048508">
        <property type="entry name" value="LDL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21691">
        <property type="entry name" value="LDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="162"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="306" mass="33678" checksum="961567F07796DBB9" modified="2009-03-03" version="1">MASTGLAAECYAQSGATGMSYTFTPMSGVTGIGIMNSAGKIGNFQNEEQCVVAYQEIVSDCYNIKNGGSWTYLRGSLEWGEIYSSPGPRNQVALEVPRYRGVSRQSEANSRHPSHAYNYKTRVITTKSRKDNFQSNIPKLNKKMARQLPPGYSLHIGYPPAEIYCNLRKTSGLAAVSLVQAQAVPKGSWYGCMIKYTPSESSTENAIETKPEIVAMGRIISDGGWYFVIADMAVLPSHQRKGLGDYVLKQLIQRIRAEPVVADVLENGGPKPYVNLLADEPGRKLYERNGFVYTAPHSLGMMLKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTI5</accession>
    <name>B8LTI5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DASH complex subunit DAD3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSTA_065210</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340450.1">
        <property type="nucleotide sequence ID" value="XM_002340409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTI5"/>
    <dbReference type="STRING" id="441959.B8LTI5"/>
    <dbReference type="GeneID" id="8109416"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_065210"/>
    <dbReference type="eggNOG" id="ENOG502SCNH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118180_0_1_1"/>
    <dbReference type="InParanoid" id="B8LTI5"/>
    <dbReference type="OMA" id="THHANTL"/>
    <dbReference type="OrthoDB" id="2443965at2759"/>
    <dbReference type="PhylomeDB" id="B8LTI5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013965">
        <property type="entry name" value="DASH_Dad3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08656">
        <property type="entry name" value="DASH_Dad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EED23063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="137" mass="14853" checksum="FAFF4BDAA115BD0F" modified="2009-03-03" version="1">MSHDNFLRSTTPSRDTSNPTSNESNPLLGSSSGLVSELEQEVLDEYSRLLENVNRLSDTLANLADSPASLTLDGLRLLERKTATVYTLLKASVYSIVLQQQIINDGEAAAAAGGGDDGYEYQHDDSAMQGEENTIMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8LU36</accession>
    <name>B8LU36_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_060060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002339895.1">
        <property type="nucleotide sequence ID" value="XM_002339854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LU36"/>
    <dbReference type="STRING" id="441959.B8LU36"/>
    <dbReference type="GeneID" id="8101057"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_060060"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010365_8_1_1"/>
    <dbReference type="InParanoid" id="B8LU36"/>
    <dbReference type="OMA" id="DMIPRIC"/>
    <dbReference type="OrthoDB" id="4226077at2759"/>
    <dbReference type="PhylomeDB" id="B8LU36"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF26">
        <property type="entry name" value="FAD-BINDING 8 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="3">
        <location>
            <begin position="214"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED22508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="433" mass="47991" checksum="BE999F3222FEE776" modified="2009-03-03" version="1">MAPLGDIDISQAYSLTVGCIVIFLLTFRLSHTVFHYLYPRLKHLVHRLSLPRPRSRLSGVLPKDWSRIALLAIYLGGTVASNVIYVSTLAEASSRAAKLCLANVVPLMVCSHEVGAHLFGVSLDLFHSVHRLLGTMAFLQGLAHGVYEVASAPVHVHDGTVVYGISASIIFASLMLSSVFKARVYEFFSQSHRACALGLVFATWRHTYNKSALSTWCIAGAAAAYALTFLIQILRIAVRNLAFARRAECLINHQGNNLEVIVFPARPWTVRAGERVNLSIPSAGLMSVFQMHPFVITWWDNNELGKLESFTLLVKPRSGFTNKLKMLPSTRHRAWIDGPYGPDRALGTPISDYGHIFMVATGIGVGAQIPYIKQLLEGYRRGVVRTQKIVLIWQMDLEADYDDVQDWLQELVSQDSGYVSGPRNGVAYLLNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUG9</accession>
    <name>B8LUG9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="2">6.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_071390</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + L-glutamine + ATP + H2O = L-asparagine + L-glutamate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="2"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341129.1">
        <property type="nucleotide sequence ID" value="XM_002341088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUG9"/>
    <dbReference type="FunCoup" id="B8LUG9">
        <property type="interactions" value="611"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LUG9"/>
    <dbReference type="GeneID" id="8107663"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_071390"/>
    <dbReference type="eggNOG" id="KOG0571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014658_2_2_1"/>
    <dbReference type="InParanoid" id="B8LUG9"/>
    <dbReference type="OMA" id="GIVCAFD"/>
    <dbReference type="OrthoDB" id="409189at2759"/>
    <dbReference type="PhylomeDB" id="B8LUG9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070981">
        <property type="term" value="P:L-asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000031">
        <property type="entry name" value="Asparagine synthase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000050">
        <property type="entry name" value="Asparagine synthetase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050795">
        <property type="entry name" value="Asn_Synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006949">
        <property type="entry name" value="PRK09431.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF2">
        <property type="entry name" value="ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="6 10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="14">
        <location>
            <begin position="2"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="11">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="370"/>
            <end position="371"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="13">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED23742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="574" mass="64713" checksum="503B9D704CEF76BC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUS1</accession>
    <name>B8LUS1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_073180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341315.1">
        <property type="nucleotide sequence ID" value="XM_002341274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUS1"/>
    <dbReference type="STRING" id="441959.B8LUS1"/>
    <dbReference type="GeneID" id="8106042"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_073180"/>
    <dbReference type="eggNOG" id="ENOG502SH56">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1016274_0_0_1"/>
    <dbReference type="InParanoid" id="B8LUS1"/>
    <dbReference type="OrthoDB" id="4207352at2759"/>
    <dbReference type="PhylomeDB" id="B8LUS1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED23928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="274" mass="31777" checksum="DB625C1798100A69" modified="2009-03-03" version="1">MAQIKIDKELMAKESTKEYEKAQNMWREFCSYKGKDPIASVYDLEPLKDFVHHLAYGIEGRYDDEAAGQGSVKVFLRETVFPTRGNKRVKRRRKHARKNHFIHLGRQLWENDYHEYTKTIIRVSLWAQMLVYVFSSARLCEYLEGVSRANSRRGLYCKISRYQIRVIRNELSESELVFQVVKDAKGMTNAPEKRPEHELYEGLSTSSQYLLLNPMLPILAMLVASDRLRDYCTSKAVLAISAPPPDEVHVLEWKDPDCPLFEGLDDPSPILCTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVB0</accession>
    <name>B8LVB0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSTA_066130</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340547.1">
        <property type="nucleotide sequence ID" value="XM_002340506.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B8LVB0">
        <property type="interactions" value="610"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LVB0"/>
    <dbReference type="GeneID" id="8109435"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_066130"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001650_18_4_1"/>
    <dbReference type="InParanoid" id="B8LVB0"/>
    <dbReference type="OrthoDB" id="4356562at2759"/>
    <dbReference type="PhylomeDB" id="B8LVB0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="18">
        <location>
            <begin position="612"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="329"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="897"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="897"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="914"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="984"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1014"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1033"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1050"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1096"/>
            <end position="1109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EED23160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1684" mass="193750" checksum="9F2335D7E068EDB6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVH0</accession>
    <name>B8LVH0_TALSN</name>
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        <submittedName>
            <fullName evidence="8">Fungal specific transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_073750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVH0"/>
    <dbReference type="STRING" id="441959.B8LVH0"/>
    <dbReference type="GeneID" id="8106670"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_073750"/>
    <dbReference type="eggNOG" id="ENOG502S0WX">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009353_0_0_1"/>
    <dbReference type="InParanoid" id="B8LVH0"/>
    <dbReference type="OMA" id="NFSMHIK"/>
    <dbReference type="OrthoDB" id="3921198at2759"/>
    <dbReference type="PhylomeDB" id="B8LVH0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF23">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED23989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="822" mass="92968" checksum="5D2D24ACEF40E534" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8LW44</accession>
    <name>B8LW44_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_074500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341459.1">
        <property type="nucleotide sequence ID" value="XM_002341418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LW44"/>
    <dbReference type="STRING" id="441959.B8LW44"/>
    <dbReference type="GeneID" id="8101238"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_074500"/>
    <dbReference type="HOGENOM" id="CLU_052541_0_0_1"/>
    <dbReference type="InParanoid" id="B8LW44"/>
    <dbReference type="OMA" id="DCYILAG"/>
    <dbReference type="OrthoDB" id="4227427at2759"/>
    <dbReference type="PhylomeDB" id="B8LW44"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED24072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="467" mass="50580" checksum="8B93F60B2C50951C" modified="2009-03-03" version="1">MQLSAKKLAVYPIDDCYILAGSIPIKGPEFSREKRVTAIMVSVKALFALYAISDIANSYPIHRHIDDFSSESHHLTPRSPNPRFKNPFDVDHYLADLDYKIPNNKDIQEWVKEARKKGALAAEGKLPDDGDGEEEDHDDDESDIDDDDDEDEDGHKHEHTTESSPRSNNNDNKDEEEEEEEDDDDDEVAQPVQGVQPSRPATTHGSAPSDIPSNTATVTVIPTSGPTHGNDDEDGIKNDVEVMQPAQNVQPSQPSTKGSSTPTTTLPSTATASPSPRPGNENGDNEDDLNEVMQPAQSAQQSQSADALDPSTSFTPSNTITGAGDATAPTQTVYVPVNVFPTRFPDIDEDENPSPSSTPLPIFPPPEDITKANLPPAAVPPSPQDATNTNVPEASEALVAQTTTTGIPDNIDAPAVNEESSNDDLDSTPTASYTNPQLPSYESQFAKIKHFLDLFTPTDESEKSYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWM8</accession>
    <name>B8LWM8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_077840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341812.1">
        <property type="nucleotide sequence ID" value="XM_002341771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWM8"/>
    <dbReference type="STRING" id="441959.B8LWM8"/>
    <dbReference type="GeneID" id="8105595"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_077840"/>
    <dbReference type="eggNOG" id="ENOG502S13F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038839_0_0_1"/>
    <dbReference type="InParanoid" id="B8LWM8"/>
    <dbReference type="OMA" id="YREFCNR"/>
    <dbReference type="OrthoDB" id="5422068at2759"/>
    <dbReference type="PhylomeDB" id="B8LWM8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED24425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="37773" checksum="7E81A7255DB08A6A" modified="2009-03-03" version="1">MVPISSIQFTCLCGSISEPGSLLSDQNTPVYAEMCSMCSVLTTHFIAVTKTLNSLQPYKNSDVATRYFCPACGCFCVFYTAPLDTWYFISRAIEHNPAIKLDVPGEPNNIFMVMRYAHILDTKDGGLAPFLLQLGDRAAPTWAGIPEPISAPQNSYDLPHTNILSMISASPENYTQQPDKDSYPTASCHCGGVALLIQCANHTAKDSSCHNYSDPAKYPTYLCACRFCRLSTGISLFPWTPVNAGNVFNMKKTSVSPDNTTPDSLIPATFSFAASSSNSNPELSLKYYWSSPNTCRSFCANCGATTSYWCAQRPDELDIAVGILRSEDGSLARKLLGWEWGRLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8LX37</accession>
    <name>B8LX37_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">hAT-like transposase RNase-H fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_061750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340074.1">
        <property type="nucleotide sequence ID" value="XM_002340033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LX37"/>
    <dbReference type="GeneID" id="8102534"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_061750"/>
    <dbReference type="HOGENOM" id="CLU_127252_0_0_1"/>
    <dbReference type="InParanoid" id="B8LX37"/>
    <dbReference type="OrthoDB" id="2976890at2759"/>
    <dbReference type="PhylomeDB" id="B8LX37"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED22687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="18007" checksum="7C1B376A6BDD7A8A" modified="2009-03-03" version="1">MEFHFLNTDFPHFTTMDWSRLSQIHNILSKFNELTLFVSEKKPQISLAVPIYYELHDLLDEASKRKERFLDLDENISLAVKEGMKKYKKYYTFMDASDTYYTALILDPRVKGDLLLDKLEDEATRREILKALRDNIHRDYSVTTMESSLLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXB9</accession>
    <name>B8LXB9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_066470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340587.1">
        <property type="nucleotide sequence ID" value="XM_002340546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXB9"/>
    <dbReference type="STRING" id="441959.B8LXB9"/>
    <dbReference type="GeneID" id="8109473"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_066470"/>
    <dbReference type="HOGENOM" id="CLU_1391057_0_0_1"/>
    <dbReference type="InParanoid" id="B8LXB9"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="PhylomeDB" id="B8LXB9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="196" mass="22034" checksum="80D854547FBBF5D6" modified="2009-03-03" version="1">MFSITFSAGTQRLLQRFSQLAQNGQSDTYGNSQPWDAATEIDDCPQELYRFSRTGLDARSVEATTPPNSPHVAPSNFITKEELKWLFAEVLGIQSAQPTSDGKDSSSNEKPEEQGNDGARIRASKVEYKTVNEVWDSAKYEYKIINSTPVPDVDELDEYIFVIRKRSHKQTKELIVYVDIKSPGLRKTETSHQGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXE0</accession>
    <name>B8LXE0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_066670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340608.1">
        <property type="nucleotide sequence ID" value="XM_002340567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXE0"/>
    <dbReference type="GeneID" id="8106051"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_066670"/>
    <dbReference type="HOGENOM" id="CLU_1961052_0_0_1"/>
    <dbReference type="InParanoid" id="B8LXE0"/>
    <dbReference type="OrthoDB" id="4365889at2759"/>
    <dbReference type="PhylomeDB" id="B8LXE0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14703" checksum="9DDAE8F37DD4D0EF" modified="2009-03-03" version="1">MDEFDLACVQDESQQSQIRQPVQSDKLTRYLDSTSGAGVERLFNSARDICHYCRGSLQPQTISDLMMYMCTSQFEIHEEKQIMLSEYLLTQEIQAAKEERTQQQITVDPISDNEEDEGLSSTEPQETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXM7</accession>
    <name>B8LXM7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_078830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341915.1">
        <property type="nucleotide sequence ID" value="XM_002341874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXM7"/>
    <dbReference type="STRING" id="441959.B8LXM7"/>
    <dbReference type="GeneID" id="8108521"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_078830"/>
    <dbReference type="eggNOG" id="ENOG502SI1I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012355_0_0_1"/>
    <dbReference type="InParanoid" id="B8LXM7"/>
    <dbReference type="OMA" id="PLAWINF"/>
    <dbReference type="OrthoDB" id="4222459at2759"/>
    <dbReference type="PhylomeDB" id="B8LXM7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056021">
        <property type="entry name" value="DUF7600"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24539">
        <property type="entry name" value="DUF7600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="207"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED24528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="686" mass="78613" checksum="53B37DD2EAE650F5" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2024-01-24" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXP4</accession>
    <name>B8LXP4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_079020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341932.1">
        <property type="nucleotide sequence ID" value="XM_002341891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXP4"/>
    <dbReference type="STRING" id="441959.B8LXP4"/>
    <dbReference type="GeneID" id="8107636"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_079020"/>
    <dbReference type="HOGENOM" id="CLU_2777646_0_0_1"/>
    <dbReference type="InParanoid" id="B8LXP4"/>
    <dbReference type="PhylomeDB" id="B8LXP4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED24545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="69" mass="8083" checksum="849A5F0625F4A6E4" modified="2009-03-03" version="1">MLLWAFNFENPIDLITGQRMEPDTNPDTGYIEGLAECLESFRVRYETIMREFAKAKVDAFSKYDENVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZ02</accession>
    <name>B8LZ02_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_069310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340897.1">
        <property type="nucleotide sequence ID" value="XM_002340856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZ02"/>
    <dbReference type="GeneID" id="8103897"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_069310"/>
    <dbReference type="eggNOG" id="ENOG502SVP6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148785_0_0_1"/>
    <dbReference type="InParanoid" id="B8LZ02"/>
    <dbReference type="OMA" id="SRFTNIG"/>
    <dbReference type="OrthoDB" id="9986861at2759"/>
    <dbReference type="PhylomeDB" id="B8LZ02"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED23510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="142" mass="16176" checksum="AE301C88758D3BB9" modified="2009-03-03" version="1">MNASELLFNMPGPRQILVISLSRYLRGQPLREILDKNWEAYPNELPRFKNVPFDFDGNDIPTALQDLKSTIKACTWDGILIGWCIRGYPERTNLLEEVISVYTKAIRKNDAGTKLMFCTGPDNLADATLRNFPKEAQEVLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZ48</accession>
    <name>B8LZ48_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_083250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478055.1">
        <property type="nucleotide sequence ID" value="XM_002478010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZ48"/>
    <dbReference type="STRING" id="441959.B8LZ48"/>
    <dbReference type="GeneID" id="8105203"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_083250"/>
    <dbReference type="eggNOG" id="ENOG502S3CQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016178_0_0_1"/>
    <dbReference type="InParanoid" id="B8LZ48"/>
    <dbReference type="OMA" id="GRERPQC"/>
    <dbReference type="OrthoDB" id="4223075at2759"/>
    <dbReference type="PhylomeDB" id="B8LZ48"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="100"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="640"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="739"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="640"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="748"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="764"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED21092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="773" mass="85585" checksum="747818AE1E4869CC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZ78</accession>
    <name>B8LZ78_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamine repeat protein-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_083540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478085.1">
        <property type="nucleotide sequence ID" value="XM_002478040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZ78"/>
    <dbReference type="STRING" id="441959.B8LZ78"/>
    <dbReference type="GeneID" id="8103317"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_083540"/>
    <dbReference type="eggNOG" id="ENOG502S7XT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054781_0_0_1"/>
    <dbReference type="InParanoid" id="B8LZ78"/>
    <dbReference type="OMA" id="QPGPAIM"/>
    <dbReference type="OrthoDB" id="2530523at2759"/>
    <dbReference type="PhylomeDB" id="B8LZ78"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="36628" checksum="8DD50AFDEEDA835F" modified="2009-03-03" version="1">MNPNPTGYPTTMQQHANPMLAAAAGYPIQSPSPGNQQFPFYAAANPMAAYPPQIQQARMQQHSFNPMQIQTSGPGGAMMAGNMGAPHANMAYSSPSPYHPTSIPTTSASPSLSQSPATAATVSMQMPSQNMTAVSNPAMLLAQQQQQQQQQQLQLQLQQQQQQRQTPTNQTPPGQQPQQSQQTQQPQQPQAAPQSPATTARERARVTALLDINAALLQELLNLQAAGKSGAPPPAATTTTPEQSSSPNSASEPASASNEAPKKPSPEYVECLKRLQSNLIYLASVTDRNKKPVSPAPAIMSPPPHMGTLNEQYSKLNELFAGVPRPAAVHQQRPSQSAIAAEAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZD2</accession>
    <name>B8LZD2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amine oxidase</fullName>
            <ecNumber evidence="11">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_089210</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="11">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="10">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10 11">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="11"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478648.1">
        <property type="nucleotide sequence ID" value="XM_002478603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZD2"/>
    <dbReference type="STRING" id="441959.B8LZD2"/>
    <dbReference type="GeneID" id="8104888"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_089210"/>
    <dbReference type="eggNOG" id="KOG1186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011500_3_1_1"/>
    <dbReference type="InParanoid" id="B8LZD2"/>
    <dbReference type="OMA" id="MYIVATD"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="PhylomeDB" id="B8LZD2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000011">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000017">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF92">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N3-terminal" evidence="13">
        <location>
            <begin position="116"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="12">
        <location>
            <begin position="249"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="9">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="10">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED21685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="685" mass="77563" checksum="24BE05195A379217" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0C8</accession>
    <name>B8M0C8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitrilotriacetate monooxygenase component A, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_084560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478188.1">
        <property type="nucleotide sequence ID" value="XM_002478143.1"/>
    </dbReference>
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    <dbReference type="STRING" id="441959.B8M0C8"/>
    <dbReference type="GeneID" id="8102738"/>
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    <dbReference type="eggNOG" id="ENOG502QSR6">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_022256_1_2_1"/>
    <dbReference type="InParanoid" id="B8M0C8"/>
    <dbReference type="OMA" id="FLMGVGH"/>
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    <dbReference type="PhylomeDB" id="B8M0C8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF16">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
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    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="6">
        <location>
            <begin position="30"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED21225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="435" mass="48280" checksum="42D05C51FE9BA4B9" modified="2009-03-03" version="1">MTESKPNRQLHLTAFMRPVSLHTGAWRYPGSYPDANFNFKHISQFAQKLEAAKFDAFFMADHLAVLNMPVEALKRSHTVTSFEPFTLLSALSAVTEKIGLAATASTTYDAPYHVARRFASLDHLSGGRAAWNIVTTGNPESSKNFGFDEHMAHTDRYKRAREFYDVVTGLWDSFADDAFIRNVETGEYFDPEKLHVLDHSGDELKGWPVIVQAGQSEPGRQLAAETAEVVFCSPKDIDAAKALYADIKGRVEKAGRKREHLKILPAALIIVGESKQDAQEKRLKLDSLVHYDSAISSLSIALGVDVSHLDPDSLLPEDLPETNGSKTSREGVEKLAKLEGLTIRQLAQRYGGYAGLAFLGSPSEIADEMETWLKEGASDGFTCTFPFLPQGLEEVTDKLIPELQRRSLFRKDYAGSTLREHFGLPRPENKFFVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0I9</accession>
    <name>B8M0I9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_085170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478249.1">
        <property type="nucleotide sequence ID" value="XM_002478204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0I9"/>
    <dbReference type="STRING" id="441959.B8M0I9"/>
    <dbReference type="GeneID" id="8106123"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_085170"/>
    <dbReference type="eggNOG" id="ENOG502T5CD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_953099_0_0_1"/>
    <dbReference type="InParanoid" id="B8M0I9"/>
    <dbReference type="OMA" id="WEDAILY"/>
    <dbReference type="OrthoDB" id="4227422at2759"/>
    <dbReference type="PhylomeDB" id="B8M0I9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED21286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="315" mass="36868" checksum="74D56D2D906254CF" modified="2009-03-03" version="1">MPQHPQHGSQVARERLNIIWEKLVCGVATERSRTDGHVEFINDFQIDHHPGFDFEALNKSGYSIETRSRALIWFKPLPEDMLERYPCKGLTKEFDDYDSTQNDGKLRNEDRTRAVHDYVEECSRLRMGRSLSTLGAERSLMDYLKIHIVESPSPYLVGPGLDGSYPQLVDYWRVGNIYETMTDTNTVQSYPLLTLQAWHTLNGKEDMILLGELYTLICAMRNRVNQRRADDPDERKALWDFPADVEYCGFQFESEIHFPVVFLSYVGPQHGRIFYAYMDRYRLVICQSKLYSFEKKESAPVDFFTRMLLSRPLQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0J7</accession>
    <name>B8M0J7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_085250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478257.1">
        <property type="nucleotide sequence ID" value="XM_002478212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0J7"/>
    <dbReference type="STRING" id="441959.B8M0J7"/>
    <dbReference type="GeneID" id="8106131"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_085250"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_1_1"/>
    <dbReference type="InParanoid" id="B8M0J7"/>
    <dbReference type="OMA" id="WYSNRPP"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="PhylomeDB" id="B8M0J7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF9">
        <property type="entry name" value="P450, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED21294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="572" mass="65476" checksum="33BC3253004E53FE" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1D4</accession>
    <name>B8M1D4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_090690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478793.1">
        <property type="nucleotide sequence ID" value="XM_002478748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1D4"/>
    <dbReference type="GeneID" id="8101560"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_090690"/>
    <dbReference type="eggNOG" id="ENOG502SYD7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1195560_0_0_1"/>
    <dbReference type="InParanoid" id="B8M1D4"/>
    <dbReference type="OrthoDB" id="5281164at2759"/>
    <dbReference type="PhylomeDB" id="B8M1D4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED21830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="26954" checksum="E98FE83F569A9D0B" modified="2009-03-03" version="1">MIQSRQNIKGALNSLPVEIHLGIIDYLDYTACTALAYTNRYFNQIVIRQSPTAREERLKFLCEVETWPIYADINYLACNQCLKLRPIHAFADRQLRGKRSRGHSESNRRFCLRCGIQKHIYLPGHVIPIVRPSPANAHGISISICSCCKFHGSESYCLAFARCESCEEVPPILHYVSNPGYQRCMHHFYCILCGRKGSIDQWEQPIWGQIDYIVREYRLYWRIDHPAMDEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1N8</accession>
    <name>B8M1N8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBL3-like ubiquitin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_093710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479088.1">
        <property type="nucleotide sequence ID" value="XM_002479043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1N8"/>
    <dbReference type="STRING" id="441959.B8M1N8"/>
    <dbReference type="GeneID" id="8102615"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_093710"/>
    <dbReference type="eggNOG" id="ENOG502S95Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055856_0_0_1"/>
    <dbReference type="InParanoid" id="B8M1N8"/>
    <dbReference type="OMA" id="NDAVAME"/>
    <dbReference type="OrthoDB" id="1043111at2759"/>
    <dbReference type="PhylomeDB" id="B8M1N8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040015">
        <property type="entry name" value="UBL3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039540">
        <property type="entry name" value="UBL3-like_ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3 HCG-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13881">
        <property type="entry name" value="Rad60-SLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBL3-like ubiquitin" evidence="2">
        <location>
            <begin position="194"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED22125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="290" mass="31279" checksum="25E4812AE12409BC" modified="2009-03-03" version="1">MASNDGNVAALEAKVDKNNHDNVETSVATSSAAAVFEPNTSENAPSSSIDPVAETATAQKDTQVDSVADTENQAKEKKDTEIENNSSSSATTAAPAVESTEEIPAATVIATASAPTQPLASSSKPEVPETVKTTEEGESSDPAQPPKETTEAEETGPELVITLLLTTGARHPFRIDRKYLKRRSVKVENDDPFNMSVYTLKELIWREWRSEWEPQPSSPSSIRLISFGKLLDDKAPLSESSLTHDAPNVIHMTVKPQEVVDEEDAKGGKSYSARDREATDRSPGCRCIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1T4</accession>
    <name>B8M1T4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phenol monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_085430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478275.1">
        <property type="nucleotide sequence ID" value="XM_002478230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1T4"/>
    <dbReference type="STRING" id="441959.B8M1T4"/>
    <dbReference type="GeneID" id="8106149"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_085430"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_9_2_1"/>
    <dbReference type="InParanoid" id="B8M1T4"/>
    <dbReference type="OMA" id="WEVAFWN"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="PhylomeDB" id="B8M1T4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF15">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="45"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="492"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED21312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="694" mass="76772" checksum="274C6DF83F6968F6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8M223</accession>
    <name>B8M223_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_087220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478450.1">
        <property type="nucleotide sequence ID" value="XM_002478405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M223"/>
    <dbReference type="STRING" id="441959.B8M223"/>
    <dbReference type="GeneID" id="8109509"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_087220"/>
    <dbReference type="eggNOG" id="ENOG502SK5J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_8_6_1"/>
    <dbReference type="InParanoid" id="B8M223"/>
    <dbReference type="OMA" id="IPWEVLD"/>
    <dbReference type="OrthoDB" id="3358371at2759"/>
    <dbReference type="PhylomeDB" id="B8M223"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF29">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="11"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED21487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="340" mass="37332" checksum="B215ABFC8BCE9DE3" modified="2009-03-03" version="1">MAVLRAQAIMKIIVVIGAGGNQGGSVARTFLNLPHWKVRAITRNPSSPAAKALEVLGAEVVQANLSDPDTLSQAFHGAHAIFLNTDFWATYRSFVATTTPKEKGPLDGEEFDPGKVAYQAEVSYGRNAAEAAATVPTLECLVYSALPAMTKSTGGKYKSHHADSKGAIADYIETELPDLAKKTSFIYLGAYNTNALLSPVLDPSDGKYKYFLPLSKAARMPIINQKESTGLFVKALIEDEAPGTKLLAYDTNSYLTYEQIRDIWSRASGKEADFVTVTVQFMHEKFKTPMELIQSVPALEEYGYTGSMKVIEPGDLKTAVRTKSWEEWMMERDWKAILEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2M1</accession>
    <name>B8M2M1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_091730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478895.1">
        <property type="nucleotide sequence ID" value="XM_002478850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2M1"/>
    <dbReference type="GeneID" id="8098559"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_091730"/>
    <dbReference type="HOGENOM" id="CLU_1278382_0_0_1"/>
    <dbReference type="InParanoid" id="B8M2M1"/>
    <dbReference type="OrthoDB" id="4223515at2759"/>
    <dbReference type="PhylomeDB" id="B8M2M1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1070">
        <property type="entry name" value="Head and neck region of the ectodomain of NDV fusion glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="216" mass="25219" checksum="17C1CA8C3928770A" modified="2009-03-03" version="1">MEPELTTDPDDRIDQVAQYITILGNKIGQLEQKVKNVEGKLTTIDQNLAHIDKRIEDMSKDVVERDDQLDTQDSLWLNVRAGELDNVWDQVTNGHEEDDIFITHGADVELDMRVLNHLHNTDEARLETAEIGFEHLYGYKFDGDNEEMIMGSPQEVRSIINMRANLKFLRAWKANSTMTDYLIDRWGNRENVYYPKSRLKQEYLELLNSYKQKGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2T9</accession>
    <name>B8M2T9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S5, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_094400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479157.1">
        <property type="nucleotide sequence ID" value="XM_002479112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2T9"/>
    <dbReference type="FunCoup" id="B8M2T9">
        <property type="interactions" value="1037"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M2T9"/>
    <dbReference type="GeneID" id="8103768"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_094400"/>
    <dbReference type="eggNOG" id="KOG3291">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063975_0_0_1"/>
    <dbReference type="InParanoid" id="B8M2T9"/>
    <dbReference type="OMA" id="KMNIVER"/>
    <dbReference type="OrthoDB" id="10264639at2759"/>
    <dbReference type="PhylomeDB" id="B8M2T9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003106">
        <property type="entry name" value="PRK04027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="55"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED22194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="213" mass="23727" checksum="9618C0F4D1ECDD30" modified="2009-03-03" version="1">MSDNGEVEVENPSGFYPALPKDVQTDSVKLFGKWSYDDVEIRDISLTDYIQIRSPVYLPHSAGRYAAKRFRKAQCPIIERLTNSIMMNGRNNGKKIMAVRIVAHTFEIIHIMTDQNPLQVAVDAIVNCGPREDSTRIGSQGTVRRQAVDVSPLRRVNQAIALLTIGAREAAFRNVKSIAEVLAEELINAAKGSSNSYAIKKKDELERVAKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2W5</accession>
    <name>B8M2W5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPI-anchored wall transfer protein</fullName>
            <ecNumber evidence="9">2.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_094660</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">A acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Endoplasmic reticulum membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the PIGW family.</text>
    </comment>
    <dbReference type="EC" id="2.3.-.-" evidence="9"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479183.1">
        <property type="nucleotide sequence ID" value="XM_002479138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2W5"/>
    <dbReference type="FunCoup" id="B8M2W5">
        <property type="interactions" value="571"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M2W5"/>
    <dbReference type="GeneID" id="8103796"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_094660"/>
    <dbReference type="eggNOG" id="KOG0411">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020802_2_2_1"/>
    <dbReference type="InParanoid" id="B8M2W5"/>
    <dbReference type="OMA" id="GLYVMQP"/>
    <dbReference type="OrthoDB" id="15270at2759"/>
    <dbReference type="PhylomeDB" id="B8M2W5"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032216">
        <property type="term" value="F:glucosaminyl-phosphatidylinositol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017321">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 9" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="105"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU280819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED22220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="507" mass="55710" checksum="A0ECC6F0FEC5DBE6" modified="2009-03-03" version="1">MEKDYKARKEAFVSNLSGGDINEINTVALVASVSALLWSTLQSRISFFSPYTPKALVADFLLNVVAILFSTTVYSTSPLLLNILLLTPVVFILLRFKPVYSRQKQAKPSRANQQQNAAGSDKSNDATKSPESSPVHPFLTTYRAAMMVVTCSSILAVDFPIFPRRFAKVENWGTSLMDLGVGSFVFSAGVVSARSILKARAAGTSQQSNLLWRLAAASRHSIPLLVLGLIRLYSVKGLDYAEHVTEYGVHWNFFFTLGFLPPFVEIFHSLYSIISSYELLALFTITVYQVALESTDLKAYILVSPRGPDLLSKNREGVFSFIGYLAIFLSGRATGLRIIPRGTANNKPSSAQQARKRVLISLAIMAVGWAVLFFFNSTPAFGYGARIPVSRRLANMPYVFWVSAFNNAQIFLFCLIETLLFPSVHKATEKETEAEKSNFATSRIMAAFNKNGLAVFLIANLLTGAVNLSFNTLDANAWQSLAILVAYMAFVTAFALGLQASGLKLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2Z6</accession>
    <name>B8M2Z6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_094970</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479214.1">
        <property type="nucleotide sequence ID" value="XM_002479169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2Z6"/>
    <dbReference type="STRING" id="441959.B8M2Z6"/>
    <dbReference type="GeneID" id="8103827"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_094970"/>
    <dbReference type="eggNOG" id="KOG2204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003818_0_2_1"/>
    <dbReference type="InParanoid" id="B8M2Z6"/>
    <dbReference type="OMA" id="PESFGWD"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="PhylomeDB" id="B8M2Z6"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000047">
        <property type="entry name" value="Mannosyl-oligosaccharide alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF101">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED22251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="502" mass="55331" checksum="01F1391132457B5B" modified="2009-03-03" version="1">MRFSPMSLPALAVVGQAVASPISKRDTASDRANAVKQAFQIAWDGYYAHAFPHDQLHPMDNTYDDYYDGWGASAIDAISTAAVMGHREIVNQIVDYIPTIDFTYSNETTISLFETTIRYLGGLLAGYDLLSGPAADLVSDKSKVDTILKQAQVLANTLSYAFETPSGVPYNNLLINNRSNDGSTTNGLATTGSLVIEWTHLADLTGNHTYAQIAQKAESYLIHPQPSWAEPFPGLVGSTIDIATGKFTDNYVTWNGGDDSFYEYLIKFFVYDPIRFSEYRDRWLAAANSTLEHLLSHPASQPDLTFVNIWNNGTTISTSEHLTGFIGGNFLLAGSVLGRQDLIDAGLAFTDSWHATYNSTATKIGPEVFAWDKAGVPADQEAFYEKAGFYITSADYVLRPEVIESYYYAYRVTGDTKYQDWAWDAFLAINSTCHVGSGYSGIENVNVVGGAGFDNEQESFLFAEVLKYSYLIHAEDADWQVKADGKNKFVFNTEAHPFTVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B8M313</accession>
    <name>B8M313_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial</fullName>
            <ecNumber evidence="4">2.1.1.201</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ubiquinone biosynthesis methyltransferase COQ5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">COQ5</name>
        <name evidence="5" type="ORF">TSTA_092310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="EC" id="2.1.1.201"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.201" evidence="4"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478952.1">
        <property type="nucleotide sequence ID" value="XM_002478907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M313"/>
    <dbReference type="FunCoup" id="B8M313">
        <property type="interactions" value="477"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M313"/>
    <dbReference type="GeneID" id="8099413"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_092310"/>
    <dbReference type="eggNOG" id="KOG1540">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_0_1_1"/>
    <dbReference type="InParanoid" id="B8M313"/>
    <dbReference type="OMA" id="MNDVMSM"/>
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</entry>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <sequence length="1148" mass="124180" checksum="D1459223FCC207B1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <subcellularLocation>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Rhodopsin_dom_fungi"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fung_rhodopsin"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
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            <end position="51"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="45"/>
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        <source>
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        </source>
    </evidence>
    <sequence length="434" mass="48408" checksum="6D59912A88715C04" modified="2009-03-03" version="1">MSTLSLVPRDIYKDVPPDPRTALQNNPTLLVCWWCTAASFAIILVRVIGRYKRTERFFTEDKVMMIGAIPLIARMTLVHLVLVWGTNNAKTEGLLEQDIHHREIGSRLVLAARVFYAVYIWLAKYTVCEFLRRLTGMVWTRTFQISLRLIEYFLASTLAVVVIATLVECHPFTHYWQVTPDPGPYCRLGYANLLTMGVCDILTDIFLVVLPVSLFLASAMSVKRKIQLTLLFASSLLLVGITGFRVPAVIQRNGIQNFRSLVASFEILAATAVANFVVIGSFLRDRGLKRAKYKRVERSLSVVGSVDHSSVRRTTITKHHWGSDADLVDGLGIRLDPELHATQRSVMRPAPVVGESIHRHHDHHDDRSLSDSHSIEDYTMTGSSTTSKTLTGIPPPSFADINDPGMSPRTLQRSVSFYDVGATVADTVTVTTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4F5</accession>
    <name>B8M4F5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycosyl hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_024720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479584.1">
        <property type="nucleotide sequence ID" value="XM_002479539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4F5"/>
    <dbReference type="STRING" id="441959.B8M4F5"/>
    <dbReference type="GeneID" id="8106689"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_024720"/>
    <dbReference type="eggNOG" id="KOG2230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005015_2_4_1"/>
    <dbReference type="InParanoid" id="B8M4F5"/>
    <dbReference type="OMA" id="AWPNLHW"/>
    <dbReference type="OrthoDB" id="408532at2759"/>
    <dbReference type="PhylomeDB" id="B8M4F5"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043534">
        <property type="entry name" value="EBDG/EBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041351">
        <property type="entry name" value="Ig_GlcNase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43536">
        <property type="entry name" value="MANNOSYLGLYCOPROTEIN ENDO-BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43536:SF1">
        <property type="entry name" value="MANNOSYLGLYCOPROTEIN ENDO-BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18368">
        <property type="entry name" value="Ig_GlcNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877535" evidence="4">
        <location>
            <begin position="21"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="7">
        <location>
            <begin position="63"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="5">
        <location>
            <begin position="231"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Exo-beta-D-glucosaminidase Ig-fold" evidence="6">
        <location>
            <begin position="778"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED19150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="892" mass="99435" checksum="C519250A16F022D2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4J0</accession>
    <name>B8M4J0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_025070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479619.1">
        <property type="nucleotide sequence ID" value="XM_002479574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4J0"/>
    <dbReference type="GeneID" id="8106724"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_025070"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="InParanoid" id="B8M4J0"/>
    <dbReference type="OMA" id="RISMMIA"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="PhylomeDB" id="B8M4J0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF45">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="17"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED19185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="530" mass="58335" checksum="EB7192EB19F72BD9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4Q5</accession>
    <name>B8M4Q5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosomal protein L14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_025670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_002479684.1">
        <property type="nucleotide sequence ID" value="XM_002479639.1"/>
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        <property type="nucleotide sequence ID" value="XM_002479640.1"/>
    </dbReference>
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        <property type="interactions" value="1096"/>
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    <dbReference type="GeneID" id="8107979"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_025670"/>
    <dbReference type="eggNOG" id="KOG3421">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082438_3_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:RNA binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="term" value="P:ribosomal large subunit biogenesis"/>
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    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23702">
        <property type="entry name" value="eL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000030">
        <property type="entry name" value="60S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_eL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="7">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED19250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="147" mass="16610" checksum="04CFAE80F52E3207" modified="2009-03-03" version="1">MAANIDIKTTSWKLVEVGRVVLIRSGPYTGKLATIVEIIDHKRVLVDGPSTQEEKTVPRHALPLSHATLTPFVIPKLPRAAGTGPVRKLWEKEEIDSKFASSSWAKKNAQVERRKNLTDFERFKVMRLKKQSRYEVLKAHAKIRASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5V3</accession>
    <name>B8M5V3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_033270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480514.1">
        <property type="nucleotide sequence ID" value="XM_002480469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5V3"/>
    <dbReference type="FunCoup" id="B8M5V3">
        <property type="interactions" value="1147"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M5V3"/>
    <dbReference type="GeneID" id="8105065"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_033270"/>
    <dbReference type="eggNOG" id="KOG3181">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058591_2_0_1"/>
    <dbReference type="InParanoid" id="B8M5V3"/>
    <dbReference type="OMA" id="NKKKWMI"/>
    <dbReference type="OrthoDB" id="10248446at2759"/>
    <dbReference type="PhylomeDB" id="B8M5V3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990145">
        <property type="term" value="P:maintenance of translational fidelity"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02413">
        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000006">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_uS3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="9">
        <location>
            <begin position="24"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED20080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="266" mass="29284" checksum="1E86DF8A3C508A6D" modified="2009-03-03" version="1">MAATQGAISKRRKFVADGVFYAELNEFFQRELAEEGYSGVEVRVTPTVTDIIIRATHTQEVLGEQGRRIRELTSLIQKRFKFPENSVSLYAAKVQNRGLSAVAQCESLRYKLLNGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRAARAKSMKFTDGFMIHSGQPAKEFIDSATRHVLLRQGVLGIKVKIMRGSDPEGKSGPQKTLPDAVTIIEPKEEQPILQPVSQDYGAKALAAQQLAEQQRLAEQQEAEGQEGAAPAEYAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6I0</accession>
    <name>B8M6I0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LipA and NB-ARC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_027390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED19442.1"/>
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        <source>
            <dbReference type="EMBL" id="EED19442.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
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            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
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                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="1 3">Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.</text>
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        <subcellularLocation>
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        <source>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EMBL" id="EED20321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="175" mass="20020" checksum="40E04E90FBA2B0A9" modified="2009-03-03" version="1">MQRQSQRQRQLNTTGTSTTTSESDSTIANFPHTLRLRGESTAYQNESTETQQQQGQDGSTSHRVRWDENVINNEGMGKKSSKVCCIYHRPRAVDESSSESESSSSSDDSDTDDDNDMRATRRSGRRQGCDHDGHEHEYDHDHGIKKVRRKRRPSPNAYERQPKNEQKPTQQPKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        <name evidence="4" type="ORF">TSTA_031080</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ATCC 10500</strain>
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    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
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        <property type="protein sequence ID" value="EED19844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002480233.1"/>
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        <property type="nucleotide sequence ID" value="XM_002480234.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADH-like_C"/>
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        <property type="entry name" value="ADH-like_N"/>
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        <property type="entry name" value="ER"/>
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        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
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        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="14"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED19844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="373" mass="39715" checksum="FC9E977C1A6450F0" modified="2009-03-03" version="1">MAAPSNQAAWINEKNAKPLEVKEAPYTKPAANELVIKNAAVAINPMDWMLQETGHLAFTWIKYPFVLGADIAGEVVEVGSEVTRFKVGDRVLAMGCGSDQDRNRAAEGAFQKYAVVLENFTSPIPSTLSFPDAAVLPLGVSTAAAGLFQKNFLNLQLPTVPPQAPTGQTLLIWGGSTSVGSNAIQLAAAAGYEVYTTASPKNFDYVKKLGASQVFDYNSKTIVKDLVAALKDKTVAGAYAIGVGSLSLCVDVISKTKGVKFVTDVGSTDIPKDKKLAGFILIPFLLGTMSRGAALWVKTRRTGVRTKFVYASDIKKTSLAKSIYADFLPQALAEGRYLAAPEPQIVGHGLENVQEGFGLLRKGVSAQKLVVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8M831</accession>
    <name>B8M831_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="5">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_032490</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="5"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480427.1">
        <property type="nucleotide sequence ID" value="XM_002480382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M831"/>
    <dbReference type="FunCoup" id="B8M831">
        <property type="interactions" value="495"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M831"/>
    <dbReference type="GeneID" id="8099862"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_032490"/>
    <dbReference type="eggNOG" id="KOG1250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021152_3_1_1"/>
    <dbReference type="InParanoid" id="B8M831"/>
    <dbReference type="OMA" id="DGWVNIH"/>
    <dbReference type="OrthoDB" id="7773036at2759"/>
    <dbReference type="PhylomeDB" id="B8M831"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06448">
        <property type="entry name" value="L-Ser-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000040">
        <property type="entry name" value="L-serine dehydratase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF2">
        <property type="entry name" value="CATABOLIC L-SERINE_THREONINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="11">
        <location>
            <begin position="16"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED19993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="378" mass="40293" checksum="8ACBE59DC12E9425" modified="2009-03-03" version="1">MEPIPPNKSQRRRPWIKTPLIESATLSKAAGCRIFLKLDCLQPSGSFKSRGIGNFILSQLSDPSNDGKKLHFYNSSGGNAGLAAVVAARDLGCPCTIVVPHSTKQMMIDKLRVAGAADVIQHGASWYEADTYLRETFIKTSKQEGSSDVIREAGTVKNVYVPPFDHPLVWEGNSTIIPELVEQLPAREDVDEAQENAQFPAEVIICSVGGGGLFNGLIQGLHEYNKSHTSNSSKGKKVKVLATETKGADSLAYSLQNGTLKSLDAITSIATTLGALCVSSQTFQYASEPPEGVEVTSVVVSDAEAARGVVTFADEMRILVEPACGVSIDVATGKKLREAVGDGKLGPNSRVVVVVCGGSTVTPEIVAEYRSRLAQGWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8M877</accession>
    <name>B8M877_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_036160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480824.1">
        <property type="nucleotide sequence ID" value="XM_002480779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M877"/>
    <dbReference type="STRING" id="441959.B8M877"/>
    <dbReference type="GeneID" id="8101887"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_036160"/>
    <dbReference type="eggNOG" id="ENOG502SZPH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1950248_0_0_1"/>
    <dbReference type="InParanoid" id="B8M877"/>
    <dbReference type="OMA" id="TYEERCF"/>
    <dbReference type="OrthoDB" id="4161095at2759"/>
    <dbReference type="PhylomeDB" id="B8M877"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="129" mass="13889" checksum="DEA40B63D02E07E1" modified="2009-03-03" version="1">MSDDNTTTSYYYSSAKTTTTGKETTGHRYTTASHTDPSGNTVVRTAHQDLGEPATYEERCFDRTGQELVSSKSGTGAGIDSSGGGGSRRIIQDMTDQDFNYDLTSTGAGYFPVKFQAAGFKRCGYKFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8E5</accession>
    <name>B8M8E5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exosome complex endonuclease 1/ribosomal RNA processing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_036800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480892.1">
        <property type="nucleotide sequence ID" value="XM_002480847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8E5"/>
    <dbReference type="FunCoup" id="B8M8E5">
        <property type="interactions" value="862"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M8E5"/>
    <dbReference type="GeneID" id="8100526"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_036800"/>
    <dbReference type="eggNOG" id="KOG1068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063514_0_1_1"/>
    <dbReference type="InParanoid" id="B8M8E5"/>
    <dbReference type="OMA" id="ENQMLSI"/>
    <dbReference type="OrthoDB" id="437922at2759"/>
    <dbReference type="PhylomeDB" id="B8M8E5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030847">
        <property type="term" value="P:termination of RNA polymerase II transcription, exosome-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="2">
        <location>
            <begin position="23"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED20458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="284" mass="29634" checksum="4C4130836A469307" modified="2009-03-03" version="1">MPLDTSTTYPLTKLRLDGRRWNELRLLQAQISTNSASSGSSYLSMGNTSIMCTVHGPHETSGAGSATEALVDIDVNIAGFAGVDRKRRAGGSDRQSSQLSTALKSAFQSHLHTYLYPHSTITVQVSVLSSDGSLFAAAINACTLALVDAGIPMPGLLCACTAGMSGSASTPRDLSGSDQDQLDPLLDLSLPEEQELPFITIGTTTALPAGSAVGAEDDVDDDMKVSVLHMETRAHTSYLDAMLAVGIDGCKQIREILEGVIKGSNAGVAPVYGGGVESDNDMDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8M1</accession>
    <name>B8M8M1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_037540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480968.1">
        <property type="nucleotide sequence ID" value="XM_002480923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8M1"/>
    <dbReference type="STRING" id="441959.B8M8M1"/>
    <dbReference type="GeneID" id="8102130"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_037540"/>
    <dbReference type="eggNOG" id="ENOG502S8B6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027006_1_0_1"/>
    <dbReference type="InParanoid" id="B8M8M1"/>
    <dbReference type="OMA" id="GVFAAPW"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="PhylomeDB" id="B8M8M1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="461" mass="51791" checksum="FA993986EBF9648B" modified="2009-03-03" version="1">MSRDARILYASDSIEYILGYLPHEVINRPCWDYFHPDEMPFAQSVHGRGVQLDKAAVLRYCRVKHKLGYWVCCECVFSVVYNVLVACTSIYRQGAFSQKRAVDAPIIRRIFTSSPRDPRYHMLSYLSNKFSQNPTNALHEPRAALFLNRFTRTLTIMFATDGVEEILDITPRQLVGKSFYSCIQEQCLHDAVRCLEDAKVNSSIAYLRFWYRNPLEEDNPSVPADPAVTNNTYDNSLYGNNTANTTFSTGSELGVAAMGGSTSQHPQQQPRLELEAVVSCTSDGLVVVLRRARPSIPLQQTLTPRSQIAANGIFASPWATNPIIPQHAMQSMPTQTWPPNPRTTHPAYNRAYGPNPMVPPGHPAYPNYINNGPGGPHPHDFYSTIRDVAVFAWGIVGINGSLEQYRKGQPSYEALPPDGIPIWNPKPEDGEFIDENQDKKADIKAEIEQQETVKRDEAFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8Z4</accession>
    <name>B8M8Z4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_111330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481281.1">
        <property type="nucleotide sequence ID" value="XM_002481236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8Z4"/>
    <dbReference type="GeneID" id="8109813"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_111330"/>
    <dbReference type="HOGENOM" id="CLU_013929_2_3_1"/>
    <dbReference type="InParanoid" id="B8M8Z4"/>
    <dbReference type="OMA" id="IECWFID"/>
    <dbReference type="OrthoDB" id="4324149at2759"/>
    <dbReference type="PhylomeDB" id="B8M8Z4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="132"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="241" mass="28054" checksum="A908B7324BCE190C" modified="2009-03-03" version="1">MAPKEYKKEEEQIAKASADFLLRKDFTGPGEPRGVGKTWVDRFLTRLPEGYQRIKQKPQEVDRTGAEHYGEIECWFIDLKLVMQELHITPKNLWNFDETGFIVGQGKNESVVTKYPKTAKRVSSLSSRESLTVVESINAEGRVIPPLIIPKGEKHMEEWYRHIQDPEWLIAPASNGFITDEIAFEWLQHFQHYTKPEYTFEWRLLIMDNHTTHLTIQPLLRELFATVGKIEGFGHIILISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8M964</accession>
    <name>B8M964_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_111950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481351.1">
        <property type="nucleotide sequence ID" value="XM_002481306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M964"/>
    <dbReference type="GeneID" id="8098850"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_111950"/>
    <dbReference type="HOGENOM" id="CLU_1856649_0_0_1"/>
    <dbReference type="InParanoid" id="B8M964"/>
    <dbReference type="OMA" id="FNDYTES"/>
    <dbReference type="OrthoDB" id="4226041at2759"/>
    <dbReference type="PhylomeDB" id="B8M964"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002874929" description="GPI anchored cell wall protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED17359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="13895" checksum="EE5217665BA3F646" modified="2009-03-03" version="1">MQFLKTFLLGALTFVVPASAATIQKRDTVDVFIWGSANFNDYTESYTFNPGECQAITAPSSGSVGSATVDENASCNVYASSDCSGNVAGTFSAPGISDTGSLRSSFGSVVCTIPGSGSGGSASTTSTAASEPTDVCDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8MA67</accession>
    <name>B8MA67_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_121390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482388.1">
        <property type="nucleotide sequence ID" value="XM_002482343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MA67"/>
    <dbReference type="GeneID" id="8099379"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_121390"/>
    <dbReference type="HOGENOM" id="CLU_1788107_0_0_1"/>
    <dbReference type="InParanoid" id="B8MA67"/>
    <dbReference type="OMA" id="NTARQCQ"/>
    <dbReference type="OrthoDB" id="4509506at2759"/>
    <dbReference type="PhylomeDB" id="B8MA67"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED18396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="16784" checksum="D03D34CAE607722C" modified="2009-03-03" version="1">MAIFLPVQDTIDAAEMAELLHKEVELRYGCPSGIVSDRDLRITTAFAYNNSMNHTLRVSLFKALYGFDLEFHIDVADNVPEGEIPAAKDRIRKLYKLRQGLRDQLNTARQCQIEYYNKRHTLKTFKRGSLVKLSTRNLKLKNKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAA1</accession>
    <name>B8MAA1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_123350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482595.1">
        <property type="nucleotide sequence ID" value="XM_002482550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAA1"/>
    <dbReference type="FunCoup" id="B8MAA1">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MAA1"/>
    <dbReference type="GeneID" id="8108247"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_123350"/>
    <dbReference type="eggNOG" id="KOG4472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024327_2_1_1"/>
    <dbReference type="InParanoid" id="B8MAA1"/>
    <dbReference type="OMA" id="PWIFFNN"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="PhylomeDB" id="B8MAA1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF7">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED18603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="449" mass="52796" checksum="C5B847766DD9A2B9" modified="2009-03-03" version="1">MTHASLKLSPDSNSRHRIPATPYHTFRERLLDSVMSLGVPRGLTKRVTITLITILLLAVAYLRFDYGYEHWYLSSGDRLLSSIKFSQSQPSTSQTTSIRADSAIISLVRNEELEGILSSMRQLETSWNSKYNYPWIFFNNVPFSEEFKTRTQAETEAECRYEVIPEEHWDVPPWIDPSQLKQSMRKMKSKGIKYAGLLSYHQMCRWNSGFFYRHPALEGYKYYWRVEPDVKFFCDITYDPFQFMADNNKTYGFTINIFDDPGTITTLWPETQSFLKSHPDYLAADNSLTWLTDRTLRPDHTDAANGYSTCHFWSNFEIGDLDFWRSERYQQFFEHLDQSGGFFYERWGDAPVHSIALGLFEDNERIHWFRDIGYQHPPYINCPDTSSSASSGSGTCQHCQPNIFTHSWGVMKEDCRINWFRQMCQSRRRHGRTMRPDEEEICQRFESVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBC7</accession>
    <name>B8MBC7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin-dependent protein kinase complex component, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_126250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482908.1">
        <property type="nucleotide sequence ID" value="XM_002482863.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482909.1">
        <property type="nucleotide sequence ID" value="XM_002482864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBC7"/>
    <dbReference type="FunCoup" id="B8MBC7">
        <property type="interactions" value="172"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MBC7"/>
    <dbReference type="GeneID" id="8098137"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_126250"/>
    <dbReference type="eggNOG" id="KOG1674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013692_3_0_1"/>
    <dbReference type="InParanoid" id="B8MBC7"/>
    <dbReference type="OMA" id="YSPMEPM"/>
    <dbReference type="OrthoDB" id="1060854at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF94">
        <property type="entry name" value="PHO85 CYCLIN-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="524" mass="57583" checksum="1B79B13D6BE76F13" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBL8</accession>
    <name>B8MBL8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_116710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481874.1">
        <property type="nucleotide sequence ID" value="XM_002481829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBL8"/>
    <dbReference type="STRING" id="441959.B8MBL8"/>
    <dbReference type="GeneID" id="8102063"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_116710"/>
    <dbReference type="eggNOG" id="ENOG502RKE6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030671_1_0_1"/>
    <dbReference type="InParanoid" id="B8MBL8"/>
    <dbReference type="OMA" id="WCLAGWG"/>
    <dbReference type="OrthoDB" id="5396at2759"/>
    <dbReference type="PhylomeDB" id="B8MBL8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF11">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="35731" checksum="356F641ABC49A6E9" modified="2009-03-03" version="1">MSSVKIPSFDNLTLDPSGPKGNAWGLFGKDNHLGMLNLLTPDVIKQSAAEEIREGARFALDWKLNALHKPAFGRESFEKKIHHKVPRAVNDDVLVFNTQSSTQWDGFRHYANQAHKLFYNGTSQETIETTDVLGIDSWVDNGGIVGRGVLIDVASYAEKNNVTFPPFESTVIPLDLVKKVAEEQQVSFRLGDILFIRVGFTKAYEQLSAEEGLALGQRAISRFAGIESSEATLRWIWENQFAAIASDAVAVESSPVDGPQVPPEWSLHQWCLAGWGMPLGEMFYLEKLASYCAKKKRWTFFFSSVPLNVPGGVASPPNAIAIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBQ7</accession>
    <name>B8MBQ7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosome biogenesis GTPase Lsg1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_119520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="415"/>
        </location>
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        <location>
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        <location>
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</entry>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">Protein modification; protein sumoylation.</text>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
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    </evidence>
    <sequence length="391" mass="43260" checksum="C711CA15BA28B55E" modified="2009-03-03" version="1">MASQERNGQSISAGKQIRLWGVKAQEKLRSANILLITFKALANEIAKNLVLAGIGSLTILDHEVVTETDLCAQFFVSQEHVGQNRAQAAAPQVRAMNPRVQLHVDTEDVRSKSPEFFKDFDITIATDLDFDTYSTINAACRISNRRFYAAGLHGFYGYAFADLISHDFVIEREKSNVAPHMQETPTRSIVSITTKRENDKVIEMVTKREIYSPLLLANSSPLPEEFTRVARKKRNVSPLLSCLRALWEFQRTSNGKLPSFSRTELETFTRLVNERHLELQLDISTIDSSFLRSFLENLGCELSPVAAFIGGSLAQDVINVLGGREQPLQNLLLFDGEKNVAPIYPLHPIFPPQIEDMAAKISPTATTAVPATSLPILPGTSVPLGNGVPTS</sequence>
</entry>
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    <accession>B8MC07</accession>
    <name>B8MC07_TALSN</name>
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        <submittedName>
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        </submittedName>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <text evidence="3">Protein modification; protein ubiquitination.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
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    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="8098180"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_121910"/>
    <dbReference type="eggNOG" id="KOG2930">
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    </dbReference>
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    <dbReference type="UniPathway" id="UPA00143"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="entry name" value="mRING-H2-C3H2C2D_RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger RING-H2-type" evidence="11">
        <location>
            <begin position="82"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED18454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="137" mass="15609" checksum="E6B93332741894AF" modified="2009-03-03" version="1">MADVEMQDASSAKDKAVKTSKSAAGESSEGKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCTFACFFYISRMLTILAGIECQANQGSSTTEECTVAWGICNHAFHFHCISRWLKTRQVCPLDNRDWEFQKYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCB1</accession>
    <name>B8MCB1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_122860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482549.1">
        <property type="nucleotide sequence ID" value="XM_002482504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCB1"/>
    <dbReference type="GeneID" id="8097751"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_122860"/>
    <dbReference type="HOGENOM" id="CLU_2005437_0_0_1"/>
    <dbReference type="InParanoid" id="B8MCB1"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877417" evidence="1">
        <location>
            <begin position="21"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="124" mass="13683" checksum="A986CDFA7CFF7190" modified="2009-03-03" version="1">MKNCLGRVLVLIKGLQKVHCSSPSDATTTYGERIELPRNAPIADLWVKIDYEPCFHEYKEVQVIADEASIGANFIHINEHLVAFTNRGTDVTFGLKSGPISLSGEAQVSTKLDVLEIDDILTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCM8</accession>
    <name>B8MCM8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_126380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482922.1">
        <property type="nucleotide sequence ID" value="XM_002482877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCM8"/>
    <dbReference type="GeneID" id="8099065"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_126380"/>
    <dbReference type="HOGENOM" id="CLU_066074_0_0_1"/>
    <dbReference type="InParanoid" id="B8MCM8"/>
    <dbReference type="OMA" id="PECAMAL"/>
    <dbReference type="OrthoDB" id="3787051at2759"/>
    <dbReference type="PhylomeDB" id="B8MCM8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED18930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="273" mass="31184" checksum="B5585C6ACC078024" modified="2009-03-03" version="1">MKFTKAWDKTKNYLGDLYDILDDKVRIFLQLCRLTEIQLSQCWAVFPEMLSGRAETYYMHHVNPDASFAQMYWAIKSYFDTESNHALYYQDWTSITLVDVRCENTGKTLPEAVEILVEKLHLCQCALGPYYISPEHLVSAIIRACQGSPEMSEVLSESTIKFETLVSRLRAKAAIMQKKEAARSTLEKPVEGIARHLRDHGDAKTVKIMALNNKVTANVGYRHAKGKANVSDKTYRAFLMDFEASYNITSDSEDEKETNNNDEDEATVYFMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCR4</accession>
    <name>B8MCR4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DUF1772-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_126740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the anthrone oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482958.1">
        <property type="nucleotide sequence ID" value="XM_002482913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCR4"/>
    <dbReference type="STRING" id="441959.B8MCR4"/>
    <dbReference type="GeneID" id="8099101"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_126740"/>
    <dbReference type="eggNOG" id="ENOG502SR2H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105974_0_0_1"/>
    <dbReference type="InParanoid" id="B8MCR4"/>
    <dbReference type="OMA" id="PFTWVFM"/>
    <dbReference type="OrthoDB" id="5954308at2759"/>
    <dbReference type="PhylomeDB" id="B8MCR4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013901">
        <property type="entry name" value="Anthrone_oxy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042">
        <property type="entry name" value="ANTHRONE OXYGENASE ENCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042:SF3">
        <property type="entry name" value="ANTHRONE OXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08592">
        <property type="entry name" value="Anthrone_oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED18966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="21925" checksum="33A25076B601E28D" modified="2009-03-03" version="1">MTTKKISSVPPIGVQATAVVSGSFLTGAMVCLTGVVIPVFLDTDAESAHLLRHWVRLYHYGHIYMPVLCIATVGLYGYSSLRLKGWNSQHWTTYAAAAATTIAMVPFTWVFMAPTNNILFGWEEMATAGAPVAELDAVRKVVVKWAWLHLARSVFPLIGVIVGFTGILQERLHTSTPCAFFTHKRDPLMPVIINPSVLCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDX2</accession>
    <name>B8MDX2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyoxalase/bleomycin resistance family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_011580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483283.1">
        <property type="nucleotide sequence ID" value="XM_002483238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MDX2"/>
    <dbReference type="STRING" id="441959.B8MDX2"/>
    <dbReference type="GeneID" id="8104999"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_011580"/>
    <dbReference type="eggNOG" id="ENOG502SU00">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_7_0_1"/>
    <dbReference type="InParanoid" id="B8MDX2"/>
    <dbReference type="OMA" id="NFEYWKT"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004493">
        <property type="term" value="F:methylmalonyl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046491">
        <property type="term" value="P:L-methylmalonyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051785">
        <property type="entry name" value="MMCE/EMCE_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048:SF6">
        <property type="entry name" value="BLR8189 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="12"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED16049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="184" mass="20797" checksum="8E734AF16B826220" modified="2009-03-03" version="1">MSGQGLKPYNRPINHIAISCSDLTALVAYYTELLGFQLIGEIRHFKRSEDQTPFEAIFVSYPSTLQELKFAILATGNGVGIECFEFIDPTIKPREEAFEFTRPGFFHICITDPNPEVLVENIKQRGGRTLGQWMDYSRYGLEEHRGIYTQDPWGNVVEIMSLTLERVASAGEAMATLLKVQAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDZ8</accession>
    <name>B8MDZ8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_011840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483309.1">
        <property type="nucleotide sequence ID" value="XM_002483264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MDZ8"/>
    <dbReference type="STRING" id="441959.B8MDZ8"/>
    <dbReference type="GeneID" id="8104032"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_011840"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092117_0_0_1"/>
    <dbReference type="InParanoid" id="B8MDZ8"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="PhylomeDB" id="B8MDZ8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF7">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="249" mass="27337" checksum="55481B1DAA6C038E" modified="2009-03-03" version="1">MGSSRPESNSVQKAAGLCAPLFGRCFSSTNLGSAAKEELLNEQGGLKIWAGNIGIFATGTASADYRLRNDPNIKEAMVSMLVADLKEDYGEGGTADKEGSQKSTSSSEASLVVDLDEEETSNNAGTSLSGSAVQNLIETCKVTITNLTAFLSPLRSLFSYNENAKVTRFIQKEKGKTEQHGGEDIISEFLVHIKWLFSFRYRQISPNIAERLIDALVFRRKKLIYCQRHQEKLQHGMGDAFVLPFDEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8ME83</accession>
    <name>B8ME83_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_015940</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483744.1">
        <property type="nucleotide sequence ID" value="XM_002483699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ME83"/>
    <dbReference type="STRING" id="441959.B8ME83"/>
    <dbReference type="GeneID" id="8106367"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_015940"/>
    <dbReference type="eggNOG" id="KOG1290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_81_2_1"/>
    <dbReference type="InParanoid" id="B8ME83"/>
    <dbReference type="OMA" id="IRRESWD"/>
    <dbReference type="OrthoDB" id="4223314at2759"/>
    <dbReference type="PhylomeDB" id="B8ME83"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="41"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED16510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="423" mass="47226" checksum="8EA76F7784DCE8FE" modified="2009-03-03" version="1">MEHAAQYRKYKEIVFIENLEDYKSGGFHPIHIGDHFKENRYQILNKLGHGRCSTVWLAEDVLNKICVAISISQAQISQESSENDTSHENTQKTIRILQHLADGTKLEEKGRSNVLLPLDIFNLSGPNGTHSCIVTHLQGQSLAMVTKRDLGRLSEVLPLPKAKRAISSLLKGFAYIHSRGVCHGDLHPGNLLLDLPDPVSQSLGRINSICGPPRIVPIERLDGKDLEPNVPKYGVEAALGRFSDLSLYSGDMKVADFGCGYFTNDPPTEIDFFGPYIVPEQYCTGLIGTASDVWTVGCAIWLLLSGRDIFGTVNDPPEKVFSIMTDTLGGPPEFILRAWRDRLPDDDLHISIHPSTSLVQRVQQLRTGNEELWMKARLNEFSEEDVALVTELLTLIFKYDPADRPTLESILRHPAMKFFGDVI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2025-04-09" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MED8</accession>
    <name>SLX4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Structure-specific endonuclease subunit slx4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">slx4</name>
        <name type="ORF">TSTA_016430</name>
    </gene>
    <organism>
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Regulatory subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with slx1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylated in response to DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SLX4 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483799.1">
        <property type="nucleotide sequence ID" value="XM_002483754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MED8"/>
    <dbReference type="SMR" id="B8MED8"/>
    <dbReference type="STRING" id="441959.B8MED8"/>
    <dbReference type="GeneID" id="8106416"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_016430"/>
    <dbReference type="eggNOG" id="ENOG502S832">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016773_0_0_1"/>
    <dbReference type="InParanoid" id="B8MED8"/>
    <dbReference type="OMA" id="SICCLWK"/>
    <dbReference type="OrthoDB" id="5349119at2759"/>
    <dbReference type="PhylomeDB" id="B8MED8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22999">
        <property type="entry name" value="SAP_SLX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03110">
        <property type="entry name" value="Endonuc_su_Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027784">
        <property type="entry name" value="Slx4_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018574">
        <property type="entry name" value="Structure-sp_endonuc_su_Slx4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09494">
        <property type="entry name" value="Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000388048" description="Structure-specific endonuclease subunit slx4">
        <location>
            <begin position="1"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="590"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="800" mass="87385" checksum="43C19E358642A232" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFU9</accession>
    <name>B8MFU9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_009380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483050.1">
        <property type="nucleotide sequence ID" value="XM_002483005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFU9"/>
    <dbReference type="STRING" id="441959.B8MFU9"/>
    <dbReference type="GeneID" id="8100799"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_009380"/>
    <dbReference type="eggNOG" id="ENOG502QT5J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_391899_0_0_1"/>
    <dbReference type="InParanoid" id="B8MFU9"/>
    <dbReference type="OMA" id="NTMMMFF"/>
    <dbReference type="OrthoDB" id="5244761at2759"/>
    <dbReference type="PhylomeDB" id="B8MFU9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="86"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED15816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="704" mass="80120" checksum="DDD5ABA74080E9F3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGF1</accession>
    <name>B8MGF1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_013710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483505.1">
        <property type="nucleotide sequence ID" value="XM_002483460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGF1"/>
    <dbReference type="STRING" id="441959.B8MGF1"/>
    <dbReference type="GeneID" id="8099170"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_013710"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_1"/>
    <dbReference type="InParanoid" id="B8MGF1"/>
    <dbReference type="OMA" id="FYTIESF"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="PhylomeDB" id="B8MGF1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF6">
        <property type="entry name" value="CYTOPLASMIC ALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="41"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED16271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="475" mass="51651" checksum="E3F00826F83A80F5" modified="2009-03-03" version="1">MQDPIAVSLIIDGVDVRAPSNGCVFEANCSVASQDDKILIQGADPNLCVLAVESCSRAFQKWKKTSPERRRKLLQRLAQLIRDRADEIRSLIESEIDSSRQWSEINLEAALDLVEEMAALVTSETMAGSIPVTNNRKAQPMIFKEPLGVVLGIAPWNSPLVLGLRAVVPPIAAGNTAILKGSELSPRIHYYIAKLFQEAGFPPGVLNFILHRPQDASLTFESMISHPAVRKCNFTGSTPVGKLIASRAAAVLKPVLLELGGKNFAIVMEDADLDKAAQLILAGAFLNNGQICMSTDIVLVSRPILPEFRERLLSLLDNASSDVTNVITQKSCSRLQSLLEDAESKGAVLTKGTNKNKPPIPATLIEGLTPEMDFYHSESFGPLLGIMAFDKDEEALRIVNSCPFGLSAAIFTRNHFHGIQLARELNDGAIHINGSTVHDEATLPHGGRGDSGWGRFGAHWGLQEFLQTKTIILNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGP0</accession>
    <name>B8MGP0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein artemis</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DNA cross-link repair 1C protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_018580</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484025.1">
        <property type="nucleotide sequence ID" value="XM_002483980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGP0"/>
    <dbReference type="STRING" id="441959.B8MGP0"/>
    <dbReference type="GeneID" id="8100968"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_018580"/>
    <dbReference type="eggNOG" id="KOG1361">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013294_0_1_1"/>
    <dbReference type="InParanoid" id="B8MGP0"/>
    <dbReference type="OMA" id="VFYFRAW"/>
    <dbReference type="OrthoDB" id="5561659at2759"/>
    <dbReference type="PhylomeDB" id="B8MGP0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF8">
        <property type="entry name" value="PROTEIN ARTEMIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23023">
        <property type="entry name" value="Anti-Pycsar_Apyc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="14">
        <location>
            <begin position="413"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="521"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="531"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED16791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="635" mass="71778" checksum="79801130A82AD4F7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MH41</accession>
    <name>B8MH41_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">GARP complex subunit Vps53, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_019180</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS53 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484089.1">
        <property type="nucleotide sequence ID" value="XM_002484044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MH41"/>
    <dbReference type="FunCoup" id="B8MH41">
        <property type="interactions" value="792"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MH41"/>
    <dbReference type="GeneID" id="8109989"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_019180"/>
    <dbReference type="eggNOG" id="KOG2180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007339_1_0_1"/>
    <dbReference type="InParanoid" id="B8MH41"/>
    <dbReference type="OMA" id="YKFAEAK"/>
    <dbReference type="OrthoDB" id="10261632at2759"/>
    <dbReference type="PhylomeDB" id="B8MH41"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.110">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 53, C-terminus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031745">
        <property type="entry name" value="Vps53_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038260">
        <property type="entry name" value="Vps53_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16854">
        <property type="entry name" value="VPS53_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps53 N-terminal" evidence="9">
        <location>
            <begin position="16"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Vps53 C-terminal" evidence="10">
        <location>
            <begin position="613"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="727"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="784"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="72"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="787"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="815"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED16855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="859" mass="95811" checksum="B218D7AF5227BBAB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHC4</accession>
    <name>B8MHC4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_021600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484337.1">
        <property type="nucleotide sequence ID" value="XM_002484292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHC4"/>
    <dbReference type="STRING" id="441959.B8MHC4"/>
    <dbReference type="GeneID" id="8098426"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_021600"/>
    <dbReference type="eggNOG" id="KOG0634">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1705428_0_0_1"/>
    <dbReference type="InParanoid" id="B8MHC4"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="PhylomeDB" id="B8MHC4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858:SF1">
        <property type="entry name" value="LD15494P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED17103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="154" mass="16989" checksum="98DF534CD90D0AA8" modified="2009-03-03" version="1">MDDCYDSLPWTFQQHETNSVNGDSKAAPTPPPPRLVDVDNSMPEGDLMWENAISNGSFSKVFGPGMRCGWVEATAEFTKRLNEVTKTIEEYLGPLSVKVKIGRLHALIDNNTEQSLAGQVMGGFFIYILFREGIAADDVATVSLKEYNLRGNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHC7</accession>
    <name>B8MHC7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">methylisocitrate lyase</fullName>
            <ecNumber evidence="4">4.1.3.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_021630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.30" evidence="4"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484340.1">
        <property type="nucleotide sequence ID" value="XM_002484295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHC7"/>
    <dbReference type="STRING" id="441959.B8MHC7"/>
    <dbReference type="GeneID" id="8098429"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_021630"/>
    <dbReference type="eggNOG" id="KOG1260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019214_2_2_1"/>
    <dbReference type="InParanoid" id="B8MHC7"/>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="PhylomeDB" id="B8MHC7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF3">
        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED17106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="361" mass="40015" checksum="C6CC373F7EE35BA4" modified="2009-03-03" version="1">MDHADYPRDTVPGVVNKIFRSQKWQGQRQRQYCFLYPKEEREELDNWELLTLIVADGDMGLGGLTHTMKITRAFVEAGVAIFHLDDFAIGAKKFITGEGRTVIPTSEHLSRLTAARTQIDVMNAETILLCRCDTNHSSYITSIVDSRDNTWVLGATKPVDPLTTIFNRALANGEDITAARKAWINSAELKTFDDAVASVASTSSIEELKSYQTAVAEATTSTSCPFLSERRALAKKHLPEPLFSQLFFDCDLPRTPEQAKNFPWDSAKEIRCGMACSAHLGIARAETRYGRVQGPELGVTYTDLHIRGYGVRDVDVEDSGYARVKFSGAYLADALLETATMNIYGAERCLRMGEGVVKGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHH5</accession>
    <name>B8MHH5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA:6-aminopenicillanic-acid-acyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_010720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483190.1">
        <property type="nucleotide sequence ID" value="XM_002483145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHH5"/>
    <dbReference type="STRING" id="441959.B8MHH5"/>
    <dbReference type="MEROPS" id="C45.001"/>
    <dbReference type="GeneID" id="8109845"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_010720"/>
    <dbReference type="eggNOG" id="ENOG502RY9N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037787_1_0_1"/>
    <dbReference type="InParanoid" id="B8MHH5"/>
    <dbReference type="OMA" id="IEFYACL"/>
    <dbReference type="OrthoDB" id="189997at2759"/>
    <dbReference type="PhylomeDB" id="B8MHH5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047794">
        <property type="entry name" value="C45_proenzyme-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047801">
        <property type="entry name" value="Peptidase_C45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005079">
        <property type="entry name" value="Peptidase_C45_hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040521">
        <property type="entry name" value="C45_proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180:SF1">
        <property type="entry name" value="BETA-ALANYL-DOPAMINE_CARCININE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180">
        <property type="entry name" value="PEPTIDASE C45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03417">
        <property type="entry name" value="AAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase C45 hydrolase" evidence="1">
        <location>
            <begin position="97"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="332" mass="37261" checksum="5EDE4DE3989FDD74" modified="2009-03-03" version="1">MRQIGKQHGTAAKDKIIRCIGFYAELFQRHCHLSWSDVRTAVRPFEENVKKMWPNLHEEMKGVADGSAQSLVDIVALNVRTEIAFGKFSDGCTSLAWLTKDNAFLGQNWDWQEKQRQNLILLKITQPNKPIIRIMTEAGIIGKIGYNHVGVGVCLNALRAPGVDPNRLPVHLALRLSLECSSASDAVQMLEKWGVASSAHMLIADKHEAFGVETSAKTMQKILRDGLGRIIHSNHFLLPHPGVVDTKWLEDSPFRVDRMRELTDELNDGPAWDMILKLFEDERNSPASICRYELGSSTFGTLFNIVMDLKGGRVVVRMGKPSQVEEVISMTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIH6</accession>
    <name>B8MIH6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_045300</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485021.1">
        <property type="nucleotide sequence ID" value="XM_002484976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIH6"/>
    <dbReference type="STRING" id="441959.B8MIH6"/>
    <dbReference type="GeneID" id="8099494"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_045300"/>
    <dbReference type="eggNOG" id="KOG2282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_11_6_1"/>
    <dbReference type="InParanoid" id="B8MIH6"/>
    <dbReference type="OMA" id="QAMAYGV"/>
    <dbReference type="OrthoDB" id="10249365at2759"/>
    <dbReference type="PhylomeDB" id="B8MIH6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02773">
        <property type="entry name" value="MopB_Res-Cmplx1_Nad11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.740:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.210:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.740:FF:000033">
        <property type="entry name" value="NUAM protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054351">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015405">
        <property type="entry name" value="NDUFS1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050123">
        <property type="entry name" value="Prok_molybdopt-oxidoreductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF13">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105">
        <property type="entry name" value="RESPIRATORY NITRATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13510">
        <property type="entry name" value="Fer2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22151">
        <property type="entry name" value="Fer4_NDSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22117">
        <property type="entry name" value="Fer4_Nqo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09326">
        <property type="entry name" value="NADH_dhqG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53706">
        <property type="entry name" value="Formate dehydrogenase/DMSO reductase, domains 1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00642">
        <property type="entry name" value="COMPLEX1_75K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="15" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="12">
        <location>
            <begin position="32"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="14">
        <location>
            <begin position="105"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="13">
        <location>
            <begin position="244"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED15068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="735" mass="80149" checksum="F017F4C7A790115A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJC1</accession>
    <name>B8MJC1_TALSN</name>
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        <submittedName>
            <fullName evidence="5">MFS transporter (Mch2), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_041860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484663.1">
        <property type="nucleotide sequence ID" value="XM_002484618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJC1"/>
    <dbReference type="FunCoup" id="B8MJC1">
        <property type="interactions" value="140"/>
    </dbReference>
    <dbReference type="GeneID" id="8102963"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_041860"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="InParanoid" id="B8MJC1"/>
    <dbReference type="OMA" id="LYAFWIN"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="PhylomeDB" id="B8MJC1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF315">
        <property type="entry name" value="TRANSPORTER MCH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED14710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="518" mass="55092" checksum="5C40246FDFF69D68" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJR2</accession>
    <name>B8MJR2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_042040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484682.1">
        <property type="nucleotide sequence ID" value="XM_002484637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJR2"/>
    <dbReference type="STRING" id="441959.B8MJR2"/>
    <dbReference type="GeneID" id="8102981"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_042040"/>
    <dbReference type="eggNOG" id="ENOG502SJPD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013866_5_3_1"/>
    <dbReference type="InParanoid" id="B8MJR2"/>
    <dbReference type="OMA" id="SCGEYLE"/>
    <dbReference type="OrthoDB" id="5429770at2759"/>
    <dbReference type="PhylomeDB" id="B8MJR2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF13">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED14729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="524" mass="57493" checksum="618A588DF10F4EA6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MK06</accession>
    <name>B8MK06_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_042970</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484776.1">
        <property type="nucleotide sequence ID" value="XM_002484731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MK06"/>
    <dbReference type="FunCoup" id="B8MK06">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="GeneID" id="8103424"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_042970"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="B8MK06"/>
    <dbReference type="OMA" id="HAFALAY"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="PhylomeDB" id="B8MK06"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF22">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="53"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED14823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="497" mass="54593" checksum="A651A41FB0A29D4C" modified="2009-03-03" version="1">MAAVIEEKSTTHTNNDISPVSDIEQSGTVVDNDEADIAPSEKSHLQRKLDWIILPPITLLFFLSFLDRSNIGNAKLDNLTKDLHMTGEQYLVTLSVFFIGYSAFEIPSNIALKLTSPRIWLPTLMLIWGVVATLMALSTSFGGLLAARFFLGATEAGVFPGAIFYLSMWYGRTALVRRVTLFYTSTSLAGAFGGILAYGIGHMSGIAGKHGWFWIFTIEGIATVVIAGICYFLIQDFPAQAKFLSQRERKVLNALLFEDNDALRDEPLSWAEVRRTFRDVKVWLYTIAWMGQALPLYTVTLFLPTIIANLGYSAANAQLLTVPPYAVATVISIGIALLSERYHTRGPFIVGSCILSIIGYTLLLSNHKVGVQYLGTFFVCAGIFPSAALIFTWIASNVSGQVKRCVAAAIQISIGDIGAVVGCQLYRPDESPRYPLGHGMALGFVVGTLVTSLLLWNLLVKENRRRDQITGGPPKDTSFLCSEDFEGDGDVRWRFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MK92</accession>
    <name>B8MK92_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">INSIG domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_046990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the INSIG family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485200.1">
        <property type="nucleotide sequence ID" value="XM_002485155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MK92"/>
    <dbReference type="STRING" id="441959.B8MK92"/>
    <dbReference type="GeneID" id="8099886"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_046990"/>
    <dbReference type="eggNOG" id="KOG4363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039316_1_0_1"/>
    <dbReference type="InParanoid" id="B8MK92"/>
    <dbReference type="OMA" id="YGVITVH"/>
    <dbReference type="OrthoDB" id="205546at2759"/>
    <dbReference type="PhylomeDB" id="B8MK92"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025929">
        <property type="entry name" value="INSIG_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301">
        <property type="entry name" value="INSULIN-INDUCED GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301:SF3">
        <property type="entry name" value="PROTEIN NSG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07281">
        <property type="entry name" value="INSIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED15247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="39266" checksum="D28416B7855B52E2" modified="2009-03-03" version="1">MSDSPHILRPTPRRPFELPSADSSTPSTPSGETQVTEGIDLLDPKNSDLASKRSGSLLNLTSSTLLGIFQPTAFEDSREEDSPWDTQAHTPIETRSNSVFATQQQNGRRFSTDAQGQVRRHVPRTGSVYYIPLVLKTSLLFACGVAYGTIIAHLHENNWITPVKLEYIDRNSYVYLLSWGVAGVAFAFVLPWLDNLWDNGTTDRSKDVGKKQSNRTLAIRSIGAFVGIAFAMRRVPWESTTQESLTLALVNPLLWYLIDRTQTGFWLSTVVALTGMGITLRMHPELIPSSSAVGVGLRNWRLEYDVEGGISKDATAVAVWLASVFYSACVCFGNIGRQLALDGSEVQHVQFSEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8ML75</accession>
    <name>B8ML75_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Monocarboxylate permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_044560</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484943.1">
        <property type="nucleotide sequence ID" value="XM_002484898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ML75"/>
    <dbReference type="GeneID" id="8104132"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_044560"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_0_1"/>
    <dbReference type="InParanoid" id="B8ML75"/>
    <dbReference type="OMA" id="YGRYNIF"/>
    <dbReference type="OrthoDB" id="5667at2759"/>
    <dbReference type="PhylomeDB" id="B8ML75"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF224">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="86"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED14990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="477" mass="51408" checksum="435593280AC7236D" modified="2009-03-03" version="1">MKWVSSENLHPEGDGTPGNGGILSSGTSASTLHLPEAPVSDEKINSIQDVQASSSTTHSTTDLPEVLSTNEKIDSVPDGGLPAWLVVLGAWCGLFCSLGWLNSIGIFQSYYETTLLHQYSASAISWIPSFEIFFTFVMSPIIGQLYDRFGPRFVILGGSFLHVFGLMMASLSTSYYQLLLSQGVCSALGICAIFQPCMSCIPSWFQRKRGIAYGIISSGTSLGGVIFPIMVSRLIKVVGYAWSMRISAFLILFLLVIVNLTVKTRLPPSSQTHKMSKKTLLQPLKEITMILVVLGFFFLTFGVFVPINYLVVQATKVGMSSNLAQYLAPILNAASLFGRLLAGVLSDRVGTYNVLMIACYLAGIFCLALWIPAANTAAVMAFTILFGMTSGAYIALAAALVVRISPIREIGYRTGLLFFIGAFSGLTASPIAGAILQREDGSYTGMQVFSGATLLVGSSFILVVRIYKTGPVLRARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLH0</accession>
    <name>B8MLH0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_049400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485456.1">
        <property type="nucleotide sequence ID" value="XM_002485411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLH0"/>
    <dbReference type="GeneID" id="8100656"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_049400"/>
    <dbReference type="eggNOG" id="ENOG502STCV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135725_1_0_1"/>
    <dbReference type="InParanoid" id="B8MLH0"/>
    <dbReference type="OrthoDB" id="4225785at2759"/>
    <dbReference type="PhylomeDB" id="B8MLH0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="109" mass="11798" checksum="26D58E564972C760" modified="2009-03-03" version="1">MEPGGESRQYESIREFTNTPPKDKGQLGANQKSTISELKILSRDDENEQRNNDLTSKDPNLNGPQTAGMTIGVSGEVDKDLKPDAEGIDEEARRTRTAQRLGPGTGIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLU6</accession>
    <name>B8MLU6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_101120</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="4"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486110.1">
        <property type="nucleotide sequence ID" value="XM_002486065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLU6"/>
    <dbReference type="STRING" id="441959.B8MLU6"/>
    <dbReference type="GeneID" id="8101800"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_101120"/>
    <dbReference type="eggNOG" id="KOG1615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036368_5_1_1"/>
    <dbReference type="InParanoid" id="B8MLU6"/>
    <dbReference type="OMA" id="EWNVDVI"/>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="PhylomeDB" id="B8MLU6"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07500">
        <property type="entry name" value="HAD_PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000143">
        <property type="entry name" value="Phosphoserine phosphatase serb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF2">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01137">
        <property type="entry name" value="C1.6.1:_Phosphoserine_Phosphat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01136">
        <property type="entry name" value="C1.6:_Phosphoserine_Phosphatas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00029">
        <property type="entry name" value="phosphoserine_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED13872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="468" mass="51907" checksum="DEF1AD269E22CD7B" modified="2009-03-03" version="1">MTETTKLAMRSERPSLRHSSMSGGSFIQDHQQYKPTPPITQNITDVLLTAGETNKNSLFYNTNPISPDPEKVTESGIVHSIFPRSPNPLPAGTTKLVATIYYKTATAHPHANTFSAEGGVLPSPSVPIGSAPTVDIEKLPREPPAPEPEPLDHLYGPFVSQLCLTHFLQILEGLHTPYQRMNTSHRCLDQEDQPRVVEVTVSPLPNPEYLSFDDLRKHESIWRFEREWNVEVVLQKESVFRRYKRLAIFDMDSTLIQEETIDEIARFVGVEKEVSAITERAMNGELDFTSSLKARVSLLKGVPADVFDKLQNIVTISPGARELCKALKALGYKIAVLSGGFQPLANWLAKELGIDYAFANHLAVDETTQTLTGKLVEGKPIIDANQKRFLLRKIAADNNIPLTQTIAIGDGANDLPMLHEAELGVAWRAKSKVQLEAPARLNGETLTDILYLLGLGDEDIKELKAIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMC4</accession>
    <name>B8MMC4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_099300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485916.1">
        <property type="nucleotide sequence ID" value="XM_002485871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMC4"/>
    <dbReference type="STRING" id="441959.B8MMC4"/>
    <dbReference type="GeneID" id="8104008"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_099300"/>
    <dbReference type="eggNOG" id="ENOG502SH59">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010508_0_0_1"/>
    <dbReference type="InParanoid" id="B8MMC4"/>
    <dbReference type="OMA" id="IGMDDHE"/>
    <dbReference type="OrthoDB" id="4223122at2759"/>
    <dbReference type="PhylomeDB" id="B8MMC4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
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    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
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        <location>
            <begin position="84"/>
            <end position="139"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="613"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="653"/>
            <end position="679"/>
        </location>
    </feature>
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        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
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        <location>
            <begin position="613"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="653"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED13678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="768" mass="86737" checksum="DE6E61B95750C045" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMI8</accession>
    <name>B8MMI8_TALSN</name>
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        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
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    </protein>
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        <name evidence="10" type="ORF">TSTA_099900</name>
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    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
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        <property type="protein sequence ID" value="EED13742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002485935.1"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002763_0_0_1"/>
    <dbReference type="InParanoid" id="B8MMI8"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
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    </dbReference>
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        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
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        <property type="entry name" value="GAF-like_dom_sf"/>
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        <property type="entry name" value="HATPase_C_sf"/>
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        <property type="entry name" value="His_kinase_dom"/>
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        <property type="entry name" value="HisK_dim/P_sf"/>
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    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="585"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1139"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="268"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="473"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="703"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1043"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="268"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="714"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1043"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED13742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1268" mass="138375" checksum="315BC5FBAAE6580B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMI9</accession>
    <name>B8MMI9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_099910</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">MFS-type transporter; part of the gene cluster that mediates the biosynthesis of the antihypercholesterolemic agents phomoidrides which are dimeric anhydrides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485981.1">
        <property type="nucleotide sequence ID" value="XM_002485936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMI9"/>
    <dbReference type="STRING" id="441959.B8MMI9"/>
    <dbReference type="GeneID" id="8105434"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_099910"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_0_1"/>
    <dbReference type="InParanoid" id="B8MMI9"/>
    <dbReference type="OMA" id="MWTVRKR"/>
    <dbReference type="OrthoDB" id="4500315at2759"/>
    <dbReference type="PhylomeDB" id="B8MMI9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="488"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="532"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="577"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="604"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="672"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="103"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="35"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="309"/>
            <end position="424"/>
        </location>
    </feature>
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        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
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        <location>
            <begin position="324"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED13743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="710" mass="77497" checksum="06B1C294973066E1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMZ9</accession>
    <name>B8MMZ9_TALSN</name>
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        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_101840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="GeneID" id="8099229"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_101840"/>
    <dbReference type="HOGENOM" id="CLU_2005440_0_0_1"/>
    <dbReference type="InParanoid" id="B8MMZ9"/>
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    <dbReference type="PhylomeDB" id="B8MMZ9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED13948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13843" checksum="EBB6AF520EE3141B" modified="2009-03-03" version="1">MDTLETINPFILAPWEECVQTNSGETPKTHTEAGGSMQIVTFSFTLGIRLEQNLYLGELAAMVHALSTLPTLKQYRITLLTSNKAAALTLRNPRQQWGQGHVCQIYKLIKGYEEMETRSLSIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNW7</accession>
    <name>B8MNW7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">rRNA processing protein Bystin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_104260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bystin family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486444.1">
        <property type="nucleotide sequence ID" value="XM_002486399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNW7"/>
    <dbReference type="FunCoup" id="B8MNW7">
        <property type="interactions" value="876"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MNW7"/>
    <dbReference type="GeneID" id="8103197"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_104260"/>
    <dbReference type="eggNOG" id="KOG3871">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029727_0_1_1"/>
    <dbReference type="InParanoid" id="B8MNW7"/>
    <dbReference type="OMA" id="TKLPVIW"/>
    <dbReference type="OrthoDB" id="2192561at2759"/>
    <dbReference type="PhylomeDB" id="B8MNW7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007955">
        <property type="entry name" value="Bystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821:SF0">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05291">
        <property type="entry name" value="Bystin"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED14206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="512" mass="56712" checksum="B2AA8E5A2052AD84" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MP09</accession>
    <name>B8MP09_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_104620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486486.1">
        <property type="nucleotide sequence ID" value="XM_002486441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MP09"/>
    <dbReference type="STRING" id="441959.B8MP09"/>
    <dbReference type="GeneID" id="8103233"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_104620"/>
    <dbReference type="eggNOG" id="ENOG502QRBS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022730_2_1_1"/>
    <dbReference type="InParanoid" id="B8MP09"/>
    <dbReference type="OMA" id="CTNAHVS"/>
    <dbReference type="OrthoDB" id="512662at2759"/>
    <dbReference type="PhylomeDB" id="B8MP09"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF213">
        <property type="entry name" value="DEPENDENT OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="64"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="521" mass="57171" checksum="6285D46E4A559841" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8MP11</accession>
    <name>B8MP11_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_104640</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486488.1">
        <property type="nucleotide sequence ID" value="XM_002486443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MP11"/>
    <dbReference type="STRING" id="441959.B8MP11"/>
    <dbReference type="GeneID" id="8103235"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_104640"/>
    <dbReference type="eggNOG" id="KOG0684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018012_3_1_1"/>
    <dbReference type="InParanoid" id="B8MP11"/>
    <dbReference type="OMA" id="WALSANT"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="PhylomeDB" id="B8MP11"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED14250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="359" mass="41183" checksum="1BE21A85CC38A331" modified="2009-03-03" version="1">MGRSIPISQQSPTTTSISLHKTLQKIVFDTSCFTFFGNRVHQICPDIWSHWNSFNEAAYIGVRSNASFYVRPWTLRGRRLMLETFDTWCNTELEPWDETDGVWNEKWGIKLNWEREKMARDHKMTLRGRSCVQVSFLWVIITNAAPMLTWLVTALLTHPELLQKFRSIAEHYISYSGNGSSRDIKFDLPRFCVEPFIQGVWKEALRLGVTSASARVVTRDSEIEGYIVKKGSVLLLPTRNMHFEERVFHHPYEFNPWRWVLLDEDSSSPSGFGQVSPEQLKRQNNSLRPFGGGTGICSGRFIAEQEIMMTAAILLHLFDIEFEQGQSIPSPNLNPQGLAAMYPLVDPKVIVSGRKTPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8MP13</accession>
    <name>B8MP13_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione-S-transferase theta, GST, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_104660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486490.1">
        <property type="nucleotide sequence ID" value="XM_002486445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MP13"/>
    <dbReference type="FunCoup" id="B8MP13">
        <property type="interactions" value="704"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MP13"/>
    <dbReference type="GeneID" id="8098687"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_104660"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_14_2_1"/>
    <dbReference type="InParanoid" id="B8MP13"/>
    <dbReference type="OMA" id="KYLELAW"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="PhylomeDB" id="B8MP13"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="89"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED14252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="240" mass="27801" checksum="6873917C1FB62419" modified="2009-03-03" version="1">MKPIILYTHQLGTNPWKCAIILEELKLPYENRFVEPGNVKKFPYTDLNPNGRVPCIEDPNTGMVLWESAAINEYLVQTYDSSGTLWCPQGPDHFIMKQWLYFQMSGQGPYYGQAGWFVFRHHEYLPSAINRYRQEIRRVIGVLDTALANKEYLVGNKCTIADLAFVTWDEMVPDICEGESFMETLHEDCTNWIAWRKRLLARPAVQRALRAKAKSLEEVGPSIIPRNWEHEKKANTTTTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MP83</accession>
    <name>B8MP83_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_105340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486560.1">
        <property type="nucleotide sequence ID" value="XM_002486515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MP83"/>
    <dbReference type="STRING" id="441959.B8MP83"/>
    <dbReference type="GeneID" id="8098755"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_105340"/>
    <dbReference type="eggNOG" id="ENOG502RRQ1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054962_0_0_1"/>
    <dbReference type="InParanoid" id="B8MP83"/>
    <dbReference type="OMA" id="QFQKNDA"/>
    <dbReference type="OrthoDB" id="536211at2759"/>
    <dbReference type="PhylomeDB" id="B8MP83"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07739">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00280)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="305" mass="34893" checksum="5778BD7D7C803E44" modified="2009-03-03" version="1">MPLQSYYHVSSEKGLSSVTSLIVGSKEAVLFDPPFLIPDANDTVTWIKNTLSTQNQKLKAVFVTHHHPDHFFSANPILEAFPEARFFAAPYVLAGINNEYDDKVVYWPSIFGRENIPEKPRKPDPFEYSFFILEGDPDSPVHLLGPVQGDSVDHTIFWLPKERTLICGDTVYARSTHVWVEEVESAALLEAWQRTIQLIEHLNPMKLIPGHIESGWEPDVAADLAHMKKYLSLFGEKITYAPKKAQVNELYEFFKNSFPQADKNLDFFLGHLSNQFGEGGKVWEENRHQNAGERGRERLQGYWFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPX5</accession>
    <name>B8MPX5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DRAP deaminase (Rib2), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_053790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486976.1">
        <property type="nucleotide sequence ID" value="XM_002486931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPX5"/>
    <dbReference type="FunCoup" id="B8MPX5">
        <property type="interactions" value="630"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MPX5"/>
    <dbReference type="GeneID" id="8098330"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_053790"/>
    <dbReference type="eggNOG" id="KOG1919">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_12_4_1"/>
    <dbReference type="InParanoid" id="B8MPX5"/>
    <dbReference type="OMA" id="QTYCKGR"/>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="PhylomeDB" id="B8MPX5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02557">
        <property type="entry name" value="PseudoU_synth_ScRIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="4">
        <location>
            <begin position="121"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED12865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="514" mass="57150" checksum="CEDBD3778C6E75FB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQ51</accession>
    <name>B8MQ51_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_055770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the SRB8-11 complex, a regulatory module of the Mediator complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487188.1">
        <property type="nucleotide sequence ID" value="XM_002487143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQ51"/>
    <dbReference type="FunCoup" id="B8MQ51">
        <property type="interactions" value="937"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MQ51"/>
    <dbReference type="GeneID" id="8102270"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_055770"/>
    <dbReference type="eggNOG" id="KOG0794">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034754_2_0_1"/>
    <dbReference type="InParanoid" id="B8MQ51"/>
    <dbReference type="OMA" id="CLLHPPH"/>
    <dbReference type="OrthoDB" id="10266018at2759"/>
    <dbReference type="PhylomeDB" id="B8MQ51"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20513">
        <property type="entry name" value="CYCLIN_CCNC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20546">
        <property type="entry name" value="CYCLIN_SpCG1C_ScCTK2-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028758">
        <property type="entry name" value="Cyclin, C/H/G types"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="51"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED13077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="326" mass="36285" checksum="58F609EDE67F61A0" modified="2009-03-03" version="1">MAANFWVSTQRRHWMFTRERLAEVRENLKANSPDHQIQLPDMRVINIFLKTELCRLAKLTHSRQQAISTAQVYMKRFYTKVDFRQTNPYLVMVTAFYLACKMEECPQHIRVVTSEARQLWPEFITNDPGKIGECEFYLISEMHSQLIVHHPYRTVLELTKVLDLTTEDVSHATTLISDQYQTDLPLLYPPHVIAVMAILLAVLFGGGGGGGGGGGGGGGGTHRNPYGHGAIVANNNPPISTSLREAGLGATLSALGSGGTNTTTATRPDPRIQRIIAWLAESEVDIKAVIECTQEMISLYEVMDGVNIQQCKETISRMIKTRNADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQF8</accession>
    <name>B8MQF8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chitin synthase activator (Chs3), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_058480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487471.1">
        <property type="nucleotide sequence ID" value="XM_002487426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQF8"/>
    <dbReference type="STRING" id="441959.B8MQF8"/>
    <dbReference type="GeneID" id="8106450"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_058480"/>
    <dbReference type="eggNOG" id="KOG1550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_126_2_1"/>
    <dbReference type="InParanoid" id="B8MQF8"/>
    <dbReference type="OMA" id="KWMKRAT"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="PhylomeDB" id="B8MQF8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATOR SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="272"/>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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</entry>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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                <person name="Fedorova-Abrams N.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF16134"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED12980.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="2352" mass="262611" checksum="AFCDFA235D7ABB4D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRB5</accession>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="entry name" value="ZnF_C2H2"/>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
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        <location>
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        <location>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="266"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED13010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="890" mass="100232" checksum="BAD15CA825D7D305" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRF8</accession>
    <name>B8MRF8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Allantoate permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_055950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487206.1">
        <property type="nucleotide sequence ID" value="XM_002487161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRF8"/>
    <dbReference type="GeneID" id="8100660"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_055950"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_4_2_1"/>
    <dbReference type="InParanoid" id="B8MRF8"/>
    <dbReference type="OMA" id="WQFWVLP"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="PhylomeDB" id="B8MRF8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF37">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="62"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED13095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="479" mass="53778" checksum="D2E7E23065CF6411" modified="2009-03-03" version="1">MSSSAQKDTAVTETNVPSEIQSLPEDTIKETSYFTSIRRYIWDDPAKSSKEKWFLFKLDIFLLSISCLGYFSKNLDQANVANAYVSGMSDALKMKGSELTYAGNVFTAGYVLGQLPAVILVTRIRPSILIPTMEVLWSIFTFCSASVKTTSQLYAIRFLIALCEGTYFPTVVYIIGSWYTKSERGKRMTIFYATASFAGMFSGYLQAGAYKGLNGVLGHAGWQWLFIVCGIISLPIAITGYFFYPDFPETTRAFYITKEEAEFARRRLIADGMKPLGASAWDRTKIFRIMKQWQFWVLPVGYFLVQGSYPIYQPVFALWLKSTHHSIYQVNVWPTGQYAVGVVVQLLAGVISDSPLLRGRRWQTLIAMQIPTIFACIVLAVWDVPIGLKYAAYYLTFTAAGVPGIYYACYIQSIWWTLTVWRTVLAPRFHAAFIGASCLGVTLCVLAVVLRLLEKHDIKKRALVDEGTGDEETARTGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSC1</accession>
    <name>B8MSC1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_000530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED11976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487630.1">
        <property type="nucleotide sequence ID" value="XM_002487585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSC1"/>
    <dbReference type="STRING" id="441959.B8MSC1"/>
    <dbReference type="GeneID" id="8108676"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_000530"/>
    <dbReference type="eggNOG" id="KOG1565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_894810_0_0_1"/>
    <dbReference type="InParanoid" id="B8MSC1"/>
    <dbReference type="OMA" id="TEDCCYL"/>
    <dbReference type="OrthoDB" id="3594103at2759"/>
    <dbReference type="PhylomeDB" id="B8MSC1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37538">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37538:SF1">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="35491" checksum="987905E4E14F53CE" modified="2009-03-03" version="1">MGKYKAMKKTKAIEQPNGATAFEGFFQNIKYSQFPPQPPFSSTIRLHDVHEDAGHSLVHFLYTGGYQTIKSPLNKGISDVAREYRKSVFVYEASRKYGIIDLENLAHQYTQRFRDQVSLSEILLETRDIFSRHPEDETWFQTFIRGELQRFLGPSGIARSLDELSKGLGRDDRFDNIVLKIVVEILSVRLRSMFKDGETPSTEMAYKDAMHAEETVYEDEPPVEEVVHEDEPPVEEVVHKEEPPVEEVVHEEQPPVEAVQASILKASPADLAFYQDWGSLNPSQKRKKVKKLRARGLPTPNEDGSIPVFVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSI9</accession>
    <name>B8MSI9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_001400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487723.1">
        <property type="nucleotide sequence ID" value="XM_002487678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSI9"/>
    <dbReference type="GeneID" id="8098634"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_001400"/>
    <dbReference type="HOGENOM" id="CLU_1661971_0_0_1"/>
    <dbReference type="InParanoid" id="B8MSI9"/>
    <dbReference type="OrthoDB" id="427924at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="159" mass="18581" checksum="A128A6CC9350B3B9" modified="2009-03-03" version="1">MTEFNDDCKEAWDTLKDILAKAPVRFLPDLTKPFLLYTDGSKEFSFEAALHQVDKNKVATAIWVIIKLRQYLDKNKFTLYTDHATRDSLNGPYTLHTNQMKKQAEPENPIKNRFKLDTATRLLYMIWENIERLCILAKAHKLILMATHDYKGHPSIQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTL1</accession>
    <name>B8MTL1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_004630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488071.1">
        <property type="nucleotide sequence ID" value="XM_002488026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTL1"/>
    <dbReference type="STRING" id="441959.B8MTL1"/>
    <dbReference type="GeneID" id="8104447"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_004630"/>
    <dbReference type="eggNOG" id="ENOG502QSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_783417_0_0_1"/>
    <dbReference type="InParanoid" id="B8MTL1"/>
    <dbReference type="OMA" id="MEGWAMW"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="PhylomeDB" id="B8MTL1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED12417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="39578" checksum="EE4028398A60FBA9" modified="2009-03-03" version="1">MHFASADSSPRHRSASNGIRTGLNPFLYVPYESWYPVIGSGDATPDFPEHGEQGSLFTPIRELTSLRSSIMNYHDENGRRCHAYHVGSYCGPNDERAMDHFDLGHHLYYIILQGELYLAPIPKDPQRVLDIGTGTGIWAIDFVNFHPSAKVIGTDLSPTQPSLVPPNLHFEIDDCCDEWAYSINSFDFIHVRGLYGCVADWDKFYKQALKHLKPGGYIEQVELSVEPKSEDGSIDGAIFEKWGKVSVQAGEAFGKSLTIVGFVDVVEHRIKVLVGPWPKDPRLKELGRVENDVGDKHIRMETGRGRPVPYGDKTGSTKLKISCIPGFVEFFNYHSTVTYGRKPSGIPQPKPSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTS5</accession>
    <name>B8MTS5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_005900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488214.1">
        <property type="nucleotide sequence ID" value="XM_002488169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTS5"/>
    <dbReference type="STRING" id="441959.B8MTS5"/>
    <dbReference type="GeneID" id="8105563"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_005900"/>
    <dbReference type="eggNOG" id="ENOG502SFRW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_30_0_1"/>
    <dbReference type="InParanoid" id="B8MTS5"/>
    <dbReference type="OMA" id="ATSCIRH"/>
    <dbReference type="OrthoDB" id="4842715at2759"/>
    <dbReference type="PhylomeDB" id="B8MTS5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="252" mass="27973" checksum="15993B8D96647440" modified="2009-03-03" version="1">MPPQKKGGLTVVKRYKALGPIWVFLDAQNAIDRLKSSRPGPGQALVLRAHRAVEKLAMRGQLVTIQWVPGHSGIEGNEQADQAAKRAASKQTAPGFEHLSLAYVRRACTEARRAAVSEWARINAVQGRHRDGRVYKMPRGWNLDPVAGKAPKRLASRYYQLKTGHAPIGTYLHRIGRRESPECQACKEPHETVRHVLFECRGRRTGRRALYRALEKAGVPLPTAAEESPEARCDGSALAFGLASLIDWESFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MU20</accession>
    <name>B8MU20_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Indoleamine 2,3-dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_006720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Produces N-formyl-kynurenine through the oxidation of tryptophan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.52" evidence="5"/>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488307.1">
        <property type="nucleotide sequence ID" value="XM_002488262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MU20"/>
    <dbReference type="STRING" id="441959.B8MU20"/>
    <dbReference type="GeneID" id="8105357"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_006720"/>
    <dbReference type="eggNOG" id="ENOG502QSE1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033932_0_0_1"/>
    <dbReference type="InParanoid" id="B8MU20"/>
    <dbReference type="OMA" id="TYELGPA"/>
    <dbReference type="OrthoDB" id="10262710at2759"/>
    <dbReference type="PhylomeDB" id="B8MU20"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.480:FF:000005">
        <property type="entry name" value="Indoleamine 2,3-dioxygenase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF3">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED12653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="498" mass="56697" checksum="B308714E2F9D4A3F" modified="2009-03-03" version="1">MTILKSVPSSTEAVFPYINHDPATLPHSIDPFTITTASGFMPYQIGPTELPPVFKPLTDLLERMPVLKLDGKPGLLATYELGKAVKGFPDLTDEIDKVLTKDGKKDLYMLTAIFRDYSYVASAYILEPCWENWCKNPEGGYGLGREVLPHTIAGPMWRCAEILDLPPFLSYAASYALFNYTLEDPSRGYEYDNLRLIRGFEHGLDPKSSEAGFILTHVDMVKETAPLIHGAVQILDGVEHDSRRTAVNEGFREILRAMEVIEASMEDMWKNSKPADYLTFRVFIFGITSQSMFPNGVIYEGINDNHPMYFRGESGANDAIIPLLDHLLQIPMPDTPLTKILHEFRAYRPRPHREFLSYVANTAEKLNIRDFAVQDDETAILYLKTLDHVRSFRWRHWLFAREYIIRRTAHPTATGGSPIVTWLPNQLSAVMDLMIEIYDTYIKDKATATTVDGPALNDSEPDLIASYKKQIVPMMEQVHEQKEKLAREVERWCKERGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUN1</accession>
    <name>B8MUN1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pro-apoptotic serine protease NMA111</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Pro-apoptotic serine protease nma111</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_108810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nuclear serine protease which mediates apoptosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <location>
            <begin position="200"/>
            <end position="248"/>
        </location>
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            <end position="814"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00002558"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00020338"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00021524"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17820"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED11699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="882" mass="97207" checksum="9B1C047D97E7EAF9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUP1</accession>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="327" mass="36487" checksum="A1E77A93C358695F" modified="2009-03-03" version="1">MEKINPLLHPPWSTKEPREAALRRVGAPSGRIREEAADNFQILLQSIPNNDIIIYSDESKLENGQTGGGYVGFQAGSQFLLKAAMTHSTAQCSPNLWICLDNLEVAIQLLSLSIGSSQAVFESFNTLAATWPSRRRLLQIESGAVRIRWVPGHANIPGNEAADCAAKEGAGKTVPTSHPWSYTAFKRHTKSQAASRAQTYWQSAAPQAYQDLEITTFSRCPLELQLPRHILGRILAARTKHRDFADYHERFNHTDAHLTCRCGARKSPIHFIFCQIAKRKAPRFPGHPSEVIPFLLGTPKGATKLAKWLTETRFFEDICPRRPPLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUW1</accession>
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        <recommendedName>
            <fullName evidence="1">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_110580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUW1"/>
    <dbReference type="GeneID" id="8107290"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_110580"/>
    <dbReference type="eggNOG" id="ENOG502SQJN">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_448471_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUW1"/>
    <dbReference type="OMA" id="ANELTHC"/>
    <dbReference type="OrthoDB" id="4490540at2759"/>
    <dbReference type="PhylomeDB" id="B8MUW1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="1">
        <location>
            <begin position="137"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="609" mass="70242" checksum="EA8F29F88A0EF719" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTA3</accession>
    <name>B8LTA3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_059750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002339864.1">
        <property type="nucleotide sequence ID" value="XM_002339823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTA3"/>
    <dbReference type="STRING" id="441959.B8LTA3"/>
    <dbReference type="GeneID" id="8101232"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_059750"/>
    <dbReference type="eggNOG" id="ENOG502SSCR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044612_0_0_1"/>
    <dbReference type="InParanoid" id="B8LTA3"/>
    <dbReference type="OMA" id="WEDEMEM"/>
    <dbReference type="OrthoDB" id="10029320at2759"/>
    <dbReference type="PhylomeDB" id="B8LTA3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20626">
        <property type="entry name" value="CYP_Pc22g25500-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="45634" checksum="9FA9D116A73192BF" modified="2009-03-03" version="1">MGETAIIPFACIVISSLLIFFARIILRERGQVLAAETTDLKTIYHTPSENRSVIAAEIIHGARNQYTKYESKSVPSEPIQRGFRIQNAFTSDNKSYVEEFVKISRNLINISSDNWEIIVSATQDAVRRWKSDAQGACESRREVELVPMVQSITLNAVLTAFFFLRKKVTTNDVTFKSLSNLAEAINETWIMSKKEDTFIPFEQNDKLRSALIEVLPDGNISDPCENPLNLILPGFETMWRVVLRGFLEVAYKAGKEHPNWREALIGYSEKPTAEQFKRASSPDGAAWKEANFPEPKIIAADVEACHLSTSIWGKTAGKFDPLRWQKLTKEQEEAFLAFGSKPFECPAKPVFGPRLVGVLVGTLLDAFPHHWTLVSAYGDAVEFGTERLSNERMGCYGLYLELIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTS3</accession>
    <name>B8LTS3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase Scy1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_070720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341052.1">
        <property type="nucleotide sequence ID" value="XM_002341011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTS3"/>
    <dbReference type="FunCoup" id="B8LTS3">
        <property type="interactions" value="802"/>
    </dbReference>
    <dbReference type="GeneID" id="8101054"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_070720"/>
    <dbReference type="eggNOG" id="KOG2137">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008724_1_0_1"/>
    <dbReference type="InParanoid" id="B8LTS3"/>
    <dbReference type="OMA" id="MAHKCIP"/>
    <dbReference type="OrthoDB" id="79687at2759"/>
    <dbReference type="PhylomeDB" id="B8LTS3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14011">
        <property type="entry name" value="PK_SCY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF6">
        <property type="entry name" value="SCY1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="32"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="672"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="758"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="818"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="843"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="891"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED23665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="912" mass="98680" checksum="8C0BED35D6A2CCBC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTW0</accession>
    <name>B8LTW0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pentatricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_071860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341177.1">
        <property type="nucleotide sequence ID" value="XM_002341136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTW0"/>
    <dbReference type="STRING" id="441959.B8LTW0"/>
    <dbReference type="GeneID" id="8107652"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_071860"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012630_2_0_1"/>
    <dbReference type="InParanoid" id="B8LTW0"/>
    <dbReference type="OMA" id="AFGTCCG"/>
    <dbReference type="OrthoDB" id="1908178at2759"/>
    <dbReference type="PhylomeDB" id="B8LTW0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033443">
        <property type="entry name" value="PROP1-like_PPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46862">
        <property type="entry name" value="OS07G0661900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46862:SF3">
        <property type="entry name" value="OS07G0661900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17177">
        <property type="entry name" value="PPR_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PROP1-like PPR" evidence="4">
        <location>
            <begin position="287"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="418"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED23790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="726" mass="83838" checksum="7E5C545AD1CAE2BE" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B8LU45</accession>
    <name>B8LU45_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_060150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002339904.1">
        <property type="nucleotide sequence ID" value="XM_002339863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LU45"/>
    <dbReference type="STRING" id="441959.B8LU45"/>
    <dbReference type="GeneID" id="8101273"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_060150"/>
    <dbReference type="HOGENOM" id="CLU_1210486_0_0_1"/>
    <dbReference type="InParanoid" id="B8LU45"/>
    <dbReference type="OrthoDB" id="4321627at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED22517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="229" mass="26594" checksum="430E08AB3C392775" modified="2009-03-03" version="1">MEQRRQMRKTGASEVLLEVQMKEKVTREFFQQDWSLILSKFQLKADDDPRLVGLLPMIKDEGLLEAQLRRLLASRHLALKEERWLQENLPWPPDNIASIPNAYRRGPDFLRNEGLSGHIQYAAVNGLSLGQRSRRLENDVRSEGIAFALLPVFSKLSHLDSSQEKELNKKLQDERTGFWKWNPSIIYHERKYVRPSNAIPHRYSGVSYPEEYAAFRRGYVASKGASQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUD7</accession>
    <name>B8LUD7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7598 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_071130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341097.1">
        <property type="nucleotide sequence ID" value="XM_002341056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUD7"/>
    <dbReference type="STRING" id="441959.B8LUD7"/>
    <dbReference type="GeneID" id="8107624"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_071130"/>
    <dbReference type="eggNOG" id="ENOG502SAQI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066685_1_0_1"/>
    <dbReference type="InParanoid" id="B8LUD7"/>
    <dbReference type="OMA" id="IAFWRIV"/>
    <dbReference type="OrthoDB" id="5327148at2759"/>
    <dbReference type="PhylomeDB" id="B8LUD7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056019">
        <property type="entry name" value="DUF7598"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24535">
        <property type="entry name" value="DUF7598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7598" evidence="3">
        <location>
            <begin position="12"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED23710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="260" mass="28545" checksum="F812E4C893F7338E" modified="2009-03-03" version="1">MSRLSKALAGPGYVILNVLRAINIITFLDLIAASVVMLIKISINNNFFFFEAVSHAFTTILGVFLVISELPFFDKFFTRFVPQLGETASFVPLSLVMLIMGVSVLGNLNNDDYSQDHMGMPFWRIVASAGILAMTMGIVNFIASFIFADSENSLTARHVRSYGAVADKVLDSKSSQRSFKLSPSGSFHNNNQADGLPTYRQVSITRSAEELRNSRFPVNISSPVREKTTTSPHATPYGETPEVTMPDLAHHPAMQGGNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUR3</accession>
    <name>B8LUR3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_073100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341307.1">
        <property type="nucleotide sequence ID" value="XM_002341266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUR3"/>
    <dbReference type="STRING" id="441959.B8LUR3"/>
    <dbReference type="GeneID" id="8110234"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_073100"/>
    <dbReference type="eggNOG" id="ENOG502SM13">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023865_0_0_1"/>
    <dbReference type="InParanoid" id="B8LUR3"/>
    <dbReference type="OMA" id="GTDPWYL"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="PhylomeDB" id="B8LUR3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED23920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="569" mass="63047" checksum="CA145AB37D638331" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8LV72</accession>
    <name>B8LV72_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_065750</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340509.1">
        <property type="nucleotide sequence ID" value="XM_002340468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LV72"/>
    <dbReference type="STRING" id="441959.B8LV72"/>
    <dbReference type="GeneID" id="8106602"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_065750"/>
    <dbReference type="eggNOG" id="KOG1745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078295_4_0_1"/>
    <dbReference type="InParanoid" id="B8LV72"/>
    <dbReference type="OrthoDB" id="5413114at2759"/>
    <dbReference type="PhylomeDB" id="B8LV72"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="9">
        <location>
            <begin position="39"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED23122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="119" mass="13487" checksum="086ED2D2A8B44C43" modified="2009-03-03" version="1">MARTKVSARKIAKKGATKTLPGGSKYPTRRVPIQGTTRRRLMREIAQDISLTADLRWQSSAILALQEAAEAFLVKEFEMTNLCAVHAHRVTIQAKDMELVDRLRRIMTGSGYRFENRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVA7</accession>
    <name>B8LVA7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_066100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340544.1">
        <property type="nucleotide sequence ID" value="XM_002340503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVA7"/>
    <dbReference type="STRING" id="441959.B8LVA7"/>
    <dbReference type="GeneID" id="8102401"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_066100"/>
    <dbReference type="HOGENOM" id="CLU_2127096_0_0_1"/>
    <dbReference type="InParanoid" id="B8LVA7"/>
    <dbReference type="OrthoDB" id="5150797at2759"/>
    <dbReference type="PhylomeDB" id="B8LVA7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED23157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="114" mass="13481" checksum="CC59130DF3B50DBB" modified="2009-03-03" version="1" fragment="single">MIQHSSQRLILCIGASKDNSTTHLNRDFYIRIPSDLQRFFPRCEFLKVEQPLYRIPKAGNHWFRMYYEHYMKQLAMETSTYNPCLLHCRDLKQGFSIIGMQTDDTLIVADEAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVJ0</accession>
    <name>B8LVJ0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein transport protein SFT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_073950</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341396.1">
        <property type="nucleotide sequence ID" value="XM_002341355.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341397.1">
        <property type="nucleotide sequence ID" value="XM_002341356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVJ0"/>
    <dbReference type="FunCoup" id="B8LVJ0">
        <property type="interactions" value="714"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LVJ0"/>
    <dbReference type="GeneID" id="8102625"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_073950"/>
    <dbReference type="eggNOG" id="KOG2887">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099529_3_0_1"/>
    <dbReference type="InParanoid" id="B8LVJ0"/>
    <dbReference type="OMA" id="PTHNEGP"/>
    <dbReference type="OrthoDB" id="660759at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF36">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SFT2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED24009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="215" mass="23894" checksum="F429E7B4A4672108" modified="2009-03-03" version="1">MASASFRENMNSLGWSRRDQDTPVRTDSSTPMLSRLRSLNPFGSGEGYLRLPTQEPGAPLPASSRREEEESFFALSRWDRMLVFGGCNLGAAVCFLLCFVMWPVLITKPRKFAILWSVGSTLFLASWAVLMGPIVYIRHLLSGPRLPFTAAYFGSIALTLYFAVGLHQSILTLFAAIFQLVALVWYLVSYFPMGSTGLQFMGRFGVQRVAGWVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8LW70</accession>
    <name>B8LW70_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GTP binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_074770</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341485.1">
        <property type="nucleotide sequence ID" value="XM_002341444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LW70"/>
    <dbReference type="FunCoup" id="B8LW70">
        <property type="interactions" value="1015"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LW70"/>
    <dbReference type="GeneID" id="8102365"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_074770"/>
    <dbReference type="eggNOG" id="KOG2484">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011106_5_5_1"/>
    <dbReference type="InParanoid" id="B8LW70"/>
    <dbReference type="OMA" id="FKLDGLW"/>
    <dbReference type="OrthoDB" id="10266128at2759"/>
    <dbReference type="PhylomeDB" id="B8LW70"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04178">
        <property type="entry name" value="Nucleostemin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000006">
        <property type="entry name" value="Nuclear GTP-binding protein NUG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000844">
        <property type="entry name" value="Nuclear GTP-binding protein NUG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014813">
        <property type="entry name" value="Gnl3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF30">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08701">
        <property type="entry name" value="GN3L_Grn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="201"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="67"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="147"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED24098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="553" mass="60883" checksum="C8B4694C53B11E5D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWU0</accession>
    <name>B8LWU0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_079290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341960.1">
        <property type="nucleotide sequence ID" value="XM_002341919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWU0"/>
    <dbReference type="STRING" id="441959.B8LWU0"/>
    <dbReference type="GeneID" id="8107603"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_079290"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_4_1"/>
    <dbReference type="InParanoid" id="B8LWU0"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="PhylomeDB" id="B8LWU0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED24573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="369" mass="42383" checksum="71E4E9F6F86466C8" modified="2009-03-03" version="1">MAVNFNSFVFAGLGLVCVGTIYCIALITHRLVFSPLAGFPGPKFAAATGWVEFYYDFFKRGAYIYEIEKMHKKYGPIVRINPEELSLHDPAFYDEIYCVASKRRTDNYSHIGKGIDFDGSHFLTTAHDHHRLRRKPLEPYFSRGGVMRLEPILHEAVQKLEKRFTEKKGKCAVVRLDHAFTAFTGDVIGTVCCEEREQFLDDPEFAPYWYKLLHTVIKSIPLFMGLPWLINIVSLLPESIVVWIDPRSKKFIDYKNMTNRHIEIAKDRKFHSIKIGSRPSLLTYLVNSELPSSELTVERLSKEAQVLLGAGTVSTARTLDFICYYVLANEDIHCKLRDELADIMTNYPAQIPSFVQLERLLSVYLRLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWX9</accession>
    <name>B8LWX9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ergosterol biosynthesis protein Erg28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_079670</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG28 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341999.1">
        <property type="nucleotide sequence ID" value="XM_002341958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWX9"/>
    <dbReference type="STRING" id="441959.B8LWX9"/>
    <dbReference type="GeneID" id="8103908"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_079670"/>
    <dbReference type="eggNOG" id="ENOG502SQHD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114589_0_0_1"/>
    <dbReference type="InParanoid" id="B8LWX9"/>
    <dbReference type="OMA" id="HSAVCYA"/>
    <dbReference type="OrthoDB" id="6485510at2759"/>
    <dbReference type="PhylomeDB" id="B8LWX9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005352">
        <property type="entry name" value="Erg28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451:SF19">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03694">
        <property type="entry name" value="Erg28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED24612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="15192" checksum="24966265913D816D" modified="2009-03-03" version="1">MAVFPSAVDGFLPYALFVTSTMALVHSVVTYIRPIPALTAFSGPSAPPPNALTAHIYGVKNIYTGLIRLYAAYNIHNRELYTLAILTYAGVLFLYGGELFIWQTTRMREAFSALFIPTTMLYWMLIQKGWYLLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXD0</accession>
    <name>B8LXD0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_066580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340598.1">
        <property type="nucleotide sequence ID" value="XM_002340557.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340599.1">
        <property type="nucleotide sequence ID" value="XM_002340558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXD0"/>
    <dbReference type="STRING" id="441959.B8LXD0"/>
    <dbReference type="GeneID" id="8099927"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_066580"/>
    <dbReference type="eggNOG" id="ENOG502S4CP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074846_1_1_1"/>
    <dbReference type="InParanoid" id="B8LXD0"/>
    <dbReference type="OrthoDB" id="10044044at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12108">
        <property type="entry name" value="Hr-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053206">
        <property type="entry name" value="Dimeric_xanthone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048:SF1">
        <property type="entry name" value="HEMERYTHRIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="2">
        <location>
            <begin position="105"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED23211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="246" mass="28494" checksum="29735ED79EAC2C6E" modified="2009-03-03" version="1">MAHVKVTSKDFLDSLNSSTLRLLCLSVVTNFRLAADDYGSFSHLRYRRRMGSGISSTSAPQLSRSDDHSDRQNTGGTMDKDSSKPTLSPAEFHIYNKFAVQMNYFHDQFRRTWDELQKMSKKDQPSQSEARAMIRMGLQFCSELHMHHRFEERHIYPVLSRRMLDFQPHHSLSKQHEKIDAGADQMQRYLEQCASGKQAFSTTEIRKIMGNFGSTLWSHLDDEVKALGAENMSKYWSLDEFRSLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYN1</accession>
    <name>B8LYN1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kinesin light chain, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_068160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340776.1">
        <property type="nucleotide sequence ID" value="XM_002340735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYN1"/>
    <dbReference type="STRING" id="441959.B8LYN1"/>
    <dbReference type="GeneID" id="8108651"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_068160"/>
    <dbReference type="eggNOG" id="KOG1840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1939534_0_0_1"/>
    <dbReference type="InParanoid" id="B8LYN1"/>
    <dbReference type="OrthoDB" id="4227289at2759"/>
    <dbReference type="PhylomeDB" id="B8LYN1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED23389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="130" mass="14735" checksum="AEED8953C6352D1C" modified="2009-03-03" version="1">MTVSNLGGLYTDQGKLKEAETMYQRALTGYEKALGPGHSSTLVIVNNLGNLYRDQGKPKEAETMYQRALAGFEKACDPNDYQTKKVAEALKRLIRSVTVNHNWKKQYFILRALLRPPLHRALGIFTWYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZR2</accession>
    <name>B8LZR2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_080770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477807.1">
        <property type="nucleotide sequence ID" value="XM_002477762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZR2"/>
    <dbReference type="STRING" id="441959.B8LZR2"/>
    <dbReference type="GeneID" id="8101382"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_080770"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055871_0_0_1"/>
    <dbReference type="InParanoid" id="B8LZR2"/>
    <dbReference type="OrthoDB" id="4523126at2759"/>
    <dbReference type="PhylomeDB" id="B8LZR2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED20844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24838" checksum="3F94913788C93467" modified="2009-03-03" version="1">MGEETEQDNPPTIASQFMIDRHNKVEVRRLHRQFDHPSVNRLHKLLEQASHDDVDHKSLAEIERYCHHCQMNRQAPRRFKFMLTNNQEFNFEIVVDVMYLDSEPVLHVVDSATSFQAAKFLKSLSTKDTWEAIHITWIDTYLGPPDVILHDAGTNFAANKFKVEAMMMGIQCHQMLVKAHSRIRKVKQYHAPLRYAFNIILAEIGSTVSKDVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZT8</accession>
    <name>B8LZT8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">inositol-3-phosphate synthase</fullName>
            <ecNumber evidence="6">5.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSTA_081030</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10716"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="5.5.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.4" evidence="6"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477833.1">
        <property type="nucleotide sequence ID" value="XM_002477788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZT8"/>
    <dbReference type="FunCoup" id="B8LZT8">
        <property type="interactions" value="663"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LZT8"/>
    <dbReference type="GeneID" id="8101408"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_081030"/>
    <dbReference type="eggNOG" id="KOG0693">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021486_2_0_1"/>
    <dbReference type="InParanoid" id="B8LZT8"/>
    <dbReference type="OMA" id="FIMGAPN"/>
    <dbReference type="OrthoDB" id="2887at2759"/>
    <dbReference type="PhylomeDB" id="B8LZT8"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000069">
        <property type="entry name" value="Inositol-3-phosphate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000204">
        <property type="entry name" value="Inositol-3-phosphate synthase 1-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11510">
        <property type="entry name" value="MYO-INOSITOL-1 PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07994">
        <property type="entry name" value="NAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0398">Inositol biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myo-inositol-1-phosphate synthase GAPDH-like" evidence="15">
        <location>
            <begin position="314"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EED20870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="520" mass="56612" checksum="6EB55FA7816C865D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZV6</accession>
    <name>B8LZV6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Esterase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_081210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477851.1">
        <property type="nucleotide sequence ID" value="XM_002477806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZV6"/>
    <dbReference type="STRING" id="441959.B8LZV6"/>
    <dbReference type="MEROPS" id="S12.950"/>
    <dbReference type="GeneID" id="8101426"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_081210"/>
    <dbReference type="eggNOG" id="ENOG502RXX3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_11_1_1"/>
    <dbReference type="InParanoid" id="B8LZV6"/>
    <dbReference type="OMA" id="YEYGINI"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="PhylomeDB" id="B8LZV6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF3">
        <property type="entry name" value="BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G07500)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="33"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED20888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="431" mass="47856" checksum="57E4417EEF581634" modified="2009-03-03" version="1">MATLQLPGDIQASLRRLLDNTTSSTKDPVAGLVYCAVNRDGDLIFNHASGSRSYSSPSKTENNPMTLDTIFWMASCTKMITGIACMQLVEQGKLALDDVEMVGRIAPELKAVKVLEGDLQTGFRLIEKQRGITLRMLLTHTAGFGYPFNNARLRDYTQNSNCIEFGGDRKGLVSLPLVNQPGVKYEYGINIDWAGILVERVSNASLDEYFQKYIFQPLGIRDIGFFPNEEMKTRLVSMHRREPDGSLHVVGHVYQFPLSERKNPEMPEDRFCSGGGGCFGTMVDYCKIIAALLNNGIYAKTNTPILKPDTVDEMYKDHIPHCPRRPNLPSQTISPLITKSNPLRPLANPVEDEKKTEGYGLTFALSHQAKNTGRKSGSASWSGLPNLYWFADRETGVGAIIGSQIMPHGDTPVLDVNDEVEKLLYMGLKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>B8M106</accession>
    <name>B8M106_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Palmitoyltransferase</fullName>
            <ecNumber evidence="13">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSTA_090250</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Palmitoyltransferase specific for casein kinase 1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="13"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478749.1">
        <property type="nucleotide sequence ID" value="XM_002478704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M106"/>
    <dbReference type="FunCoup" id="B8M106">
        <property type="interactions" value="629"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M106"/>
    <dbReference type="GeneID" id="8108113"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_090250"/>
    <dbReference type="eggNOG" id="KOG0509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012510_1_0_1"/>
    <dbReference type="InParanoid" id="B8M106"/>
    <dbReference type="OMA" id="FWVGFRY"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="PhylomeDB" id="B8M106"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="13 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="550"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="164"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="197"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="15">
        <location>
            <begin position="452"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="614"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EED21786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="740" mass="81683" checksum="1D5B8ECD4566D850" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8M170</accession>
    <name>B8M170_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multicopper oxidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_082450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477975.1">
        <property type="nucleotide sequence ID" value="XM_002477930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M170"/>
    <dbReference type="STRING" id="441959.B8M170"/>
    <dbReference type="GeneID" id="8107703"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_082450"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_842012_0_0_1"/>
    <dbReference type="InParanoid" id="B8M170"/>
    <dbReference type="OMA" id="IQWESKE"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="PhylomeDB" id="B8M170"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002874595" evidence="5">
        <location>
            <begin position="22"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="32"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="150"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED21012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="360" mass="40180" checksum="83165A8E661C1E2D" modified="2009-03-03" version="1">MTISSPRLWYTLLANLPLAIAIRQPHYILRIASENITVACRTRLSAVVNGTVPGPAIYLKENQTTWVRVYNDLLHDNTTMFVAPYSDGTPQASQWLIKAQNFFDYELRPEIGAAGSSFYHFHVGFQAVTASGPLIVEEADGEVPYDYDEDRMISFSELFNNTDKAVEDALTAPLKRLQVNGNGFPALLGNETDAFGKLPDNAPPSSSNDTCHPEIIQVEPNKTYRFRAIGGVALSPLVFTLEDHRNLTIVAADSYYTQPASTDIIQMGGGQRYDFLLRTKTEDELKVLGKTDFWVQIESRYREENSTFYALLSYTSNQSASAAPSSPPGQHPVSIPYSLQDWMEYTLEPLNQMGFQALIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1G9</accession>
    <name>B8M1G9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_091050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21865.1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_091050"/>
    <dbReference type="eggNOG" id="ENOG502ST1T">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_834643_0_0_1"/>
    <dbReference type="InParanoid" id="B8M1G9"/>
    <dbReference type="OrthoDB" id="3880401at2759"/>
    <dbReference type="PhylomeDB" id="B8M1G9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED21865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="333" mass="36204" checksum="68902924C908450F" modified="2009-03-03" version="1">MAAPTACGSDQNRPCKGCWVWFNALCSCLKSPGSCSTSKANPPYWVLVNPTLITSSVLVPDFRDVQKNHATLRDAVWDFGQTVSVPRLEALATNTAHSKTQDPVHMHACPVNPAVNAKEGKMATPDQLYHVLFVTSHLQKDPNGKFQKLRITGTYVSLESAKKAAHQCLFDAGYELEWFKKYEIGDSENVNGQVVHAVAPAGSTYRVRVLTTPNTINKPLPNHEDGRIAADLYYVVQIKSGLEDEESRDINIEGVFTSYSEARESALRVLLDAGDGVSKDSFAAYDEAGPGQADCGYGDNIIVHAVGNNGENFLVSVVKGQVLESVRLAEASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8M226</accession>
    <name>B8M226_TALSN</name>
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        <submittedName>
            <fullName evidence="6">SH3 domain protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">TSTA_087260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002478408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M226"/>
    <dbReference type="STRING" id="441959.B8M226"/>
    <dbReference type="GeneID" id="8100855"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_087260"/>
    <dbReference type="eggNOG" id="ENOG502SF40">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018830_0_1_1"/>
    <dbReference type="InParanoid" id="B8M226"/>
    <dbReference type="OMA" id="PFNDPVN"/>
    <dbReference type="OrthoDB" id="4227587at2759"/>
    <dbReference type="PhylomeDB" id="B8M226"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="443"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="224"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="309"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="407"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="500"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="82"/>
            <end position="173"/>
        </location>
    </feature>
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        <location>
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            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
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            <end position="526"/>
        </location>
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        <location>
            <begin position="527"/>
            <end position="540"/>
        </location>
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            <begin position="600"/>
            <end position="615"/>
        </location>
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            <begin position="637"/>
            <end position="662"/>
        </location>
    </feature>
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        <location>
            <begin position="672"/>
            <end position="683"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED21490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="683" mass="68961" checksum="B2B2FED41D14450E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8M251</accession>
    <name>B8M251_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydantoin racemase (Dcg1), putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">TSTA_087510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HyuE racemase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002478433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M251"/>
    <dbReference type="STRING" id="441959.B8M251"/>
    <dbReference type="GeneID" id="8100880"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_087510"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_402889_0_0_1"/>
    <dbReference type="InParanoid" id="B8M251"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12500">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052186">
        <property type="entry name" value="Hydantoin_racemase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053714">
        <property type="entry name" value="Iso_Racemase_Enz_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047:SF5">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="439"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED21515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="683" mass="75084" checksum="79320B3CF0DEFE64" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8M260</accession>
    <name>B8M260_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BZIP transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_087600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002478442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M260"/>
    <dbReference type="GeneID" id="8100889"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_087600"/>
    <dbReference type="eggNOG" id="ENOG502RZFH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020925_1_1_1"/>
    <dbReference type="InParanoid" id="B8M260"/>
    <dbReference type="OMA" id="MRWQIEP"/>
    <dbReference type="OrthoDB" id="4161589at2759"/>
    <dbReference type="PhylomeDB" id="B8M260"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="73"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED21524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="524" mass="59195" checksum="B497CAF9D0071744" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8M293</accession>
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            <fullName evidence="2">Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal domain-containing protein</fullName>
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        <name evidence="3" type="ORF">TSTA_087930</name>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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            <taxon>Eukaryota</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
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    <dbReference type="PhylomeDB" id="B8M293"/>
    <dbReference type="Proteomes" id="UP000001745">
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        <property type="entry name" value="Urb2"/>
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            <end position="1505"/>
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            <begin position="138"/>
            <end position="149"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10441"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED21557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1507" mass="169312" checksum="ED7D7A5F3B38AF44" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2N7</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">TSTA_091890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21948.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="441959.B8M2N7"/>
    <dbReference type="GeneID" id="8098575"/>
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    <dbReference type="eggNOG" id="ENOG502T2BP">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065832_0_0_1"/>
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    <dbReference type="OMA" id="DWKECAD"/>
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    <dbReference type="PhylomeDB" id="B8M2N7"/>
    <dbReference type="Proteomes" id="UP000001745">
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    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="222"/>
            <end position="291"/>
        </location>
    </feature>
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        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
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        <location>
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            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="291" mass="33988" checksum="3FA9674DD7A918A6" modified="2009-03-03" version="1">MTAVKTPMSISALLNPQQQNGDINMRHHIDLPLRQMQIGDMNSMQYSQADYRHYQNTSRRIQHESDEQRSLDDKRLQTAGGYRYERFDSVSSTSSTTISERRRAPRPKYTDEEMYFIWYHRVDLDEEWRDCTEAFNKQFPSQGRSERNTQGIQCKFYRFINAKKCPTVREQRRLKDGEFMAHGRSSRGRLLPKFGVVEWCHVWYPWMRAEHAIAGLHPGPQLHPVEPQYQQHQHVQGSQKMPSEKQMMRTYSHSSISSSAASILSSEASTPEPYTPSAYSDDIASDEEMVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2N8</accession>
    <name>B8M2N8_TALSN</name>
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        <recommendedName>
            <fullName evidence="3">Transcription factor Iwr1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_091900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IWR1/SLC7A6OS family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002478867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2N8"/>
    <dbReference type="STRING" id="441959.B8M2N8"/>
    <dbReference type="GeneID" id="8098576"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_091900"/>
    <dbReference type="eggNOG" id="ENOG502SE90">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042180_0_0_1"/>
    <dbReference type="InParanoid" id="B8M2N8"/>
    <dbReference type="OMA" id="EYWEHFA"/>
    <dbReference type="OrthoDB" id="6255506at2759"/>
    <dbReference type="PhylomeDB" id="B8M2N8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040150">
        <property type="entry name" value="Iwr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013883">
        <property type="entry name" value="TF_Iwr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28063">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN IWR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28063:SF1">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN IWR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08574">
        <property type="entry name" value="Iwr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor Iwr1" evidence="3">
        <location>
            <begin position="400"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="219"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="88"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="524"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED21949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="558" mass="61705" checksum="9856C56AAF7A29E9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8M307</accession>
    <name>B8M307_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar membrane-associated protein IML1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Vacuolar membrane-associated protein iml1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_092250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IML1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002478901.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B8M307">
        <property type="interactions" value="649"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M307"/>
    <dbReference type="GeneID" id="8099407"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_092250"/>
    <dbReference type="eggNOG" id="KOG3572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000935_1_1_1"/>
    <dbReference type="InParanoid" id="B8M307"/>
    <dbReference type="OMA" id="SWMNATP"/>
    <dbReference type="OrthoDB" id="39497at2759"/>
    <dbReference type="PhylomeDB" id="B8M307"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
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</entry>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED22266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="356" mass="39143" checksum="58B34BCB02359B6E" modified="2009-03-03" version="1">MLHYRTEGFNGSAVKYSPFFDNRLGVSASANFGLVGNGRLYILELTPNGVVPAKFYTTQDALYDLAWSEVHENQVLVASGDGSIKLFDSSVNDFPVQAWKEHNREVFSVHWNLVAKENFCSSSWDGTVKVWSPQRPQSLLTLPTHSCTYSAAFSPHSPDILSCVTSDSHIRIFDLRTPASASNHLTMQIPIHGGPVPNQVGMPPQGAGAAAPPSECLTHDWNKYRSSVIATAGVDRVVRTFDIRAPQHGPMAVMPGHGYAVRKLAWSPHLSSLLLTASYDMTCRVWNDRGDAQADVDPMRMGPTGPILGEELGCMSQHTEFVTGVDWCLFGAEGWCATVGWDESLYVWDVRAIMKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3B8</accession>
    <name>B8M3B8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear segregation protein (Bfr1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_095390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479253.1">
        <property type="nucleotide sequence ID" value="XM_002479208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3B8"/>
    <dbReference type="FunCoup" id="B8M3B8">
        <property type="interactions" value="189"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M3B8"/>
    <dbReference type="GeneID" id="8103866"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_095390"/>
    <dbReference type="eggNOG" id="ENOG502QRKP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023943_1_0_1"/>
    <dbReference type="InParanoid" id="B8M3B8"/>
    <dbReference type="OMA" id="AHWKEDQ"/>
    <dbReference type="OrthoDB" id="2195113at2759"/>
    <dbReference type="PhylomeDB" id="B8M3B8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027:SF2">
        <property type="entry name" value="LEBERCILIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="NUCLEAR SEGREGATION PROTEIN BFR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="445"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="163"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="445"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED22290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="499" mass="55665" checksum="3BA34BF0309F3B11" modified="2009-03-03" version="1">MASTATDAAVGQKTRPTKPDEAAYKAKLAAAEKEHTAAQEKLNQIKAKIESAKPNNQDSPAAKRQKELRAELSAIRQKQQGFKSARSSTQEKLNALDATLKARVAEQNNSRGKIAFKNVEEIDKEIVRLEKQVDSGNMRLVDEKKALSDISSLRKQRKNFAGLDDGQKNIDALKKQIAELKKTLDNPEARALSDKYNEIQQELDSIKAEQDSAFKNLNSLRDERTKLQQEQQAKFTAIRELKDTYYKERKAWKEHEDEVWRARRERQKAEREAFEREKKKKIADKKLEEASRPAYTDEILTAQGLIRHFDPNYDFAALGLDDTKKTAGGAFRAEVGRTVDESGIKGMKVVKKDEEDYFVGTGGKKGKKGKKGGNASPAPAADSKFNLSFGVIEDFAKVKVDQPMSQADVPAVVEKLAAKITEWKKNQAAKTEENIKKAKEEIERLEEESQRATDHAKKVAQTNAGVNGHVSAEAEAKQEKDGADDAADELKKAALEDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3M7</accession>
    <name>B8M3M7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Meiosis induction protein kinase (Ime2), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_096480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479362.1">
        <property type="nucleotide sequence ID" value="XM_002479317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3M7"/>
    <dbReference type="STRING" id="441959.B8M3M7"/>
    <dbReference type="GeneID" id="8103491"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_096480"/>
    <dbReference type="eggNOG" id="KOG0661">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011172_0_0_1"/>
    <dbReference type="InParanoid" id="B8M3M7"/>
    <dbReference type="OMA" id="GNWYNKA"/>
    <dbReference type="OrthoDB" id="2158884at2759"/>
    <dbReference type="PhylomeDB" id="B8M3M7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07830">
        <property type="entry name" value="STKc_MAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000233">
        <property type="entry name" value="Meiosis induction protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000314">
        <property type="entry name" value="Serine threonine-protein kinase mak"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="363"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="718"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="617"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="752"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED22399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="790" mass="87359" checksum="3972677EF7432530" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4M4</accession>
    <name>B8M4M4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_025360</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>propanoyl-CoA + oxaloacetate + H2O = (2S,3S)-2-methylcitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23780"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58853"/>
            <dbReference type="EC" id="2.3.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479653.1">
        <property type="nucleotide sequence ID" value="XM_002479608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4M4"/>
    <dbReference type="STRING" id="441959.B8M4M4"/>
    <dbReference type="GeneID" id="8106753"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_025360"/>
    <dbReference type="eggNOG" id="KOG2617">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022049_2_1_1"/>
    <dbReference type="InParanoid" id="B8M4M4"/>
    <dbReference type="OMA" id="IDHGFNA"/>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="PhylomeDB" id="B8M4M4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050440">
        <property type="term" value="F:2-methylcitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019629">
        <property type="term" value="P:propionate catabolic process, 2-methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF15">
        <property type="entry name" value="CITRATE SYNTHASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED19219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="467" mass="51465" checksum="C1282A3E5936B431" modified="2009-03-03" version="1">MLSSTRTTFHALKLGQPLSRPLTVFTRGYATAEPDLKTTLKEVIPEKRELLAKVKARGDEVIGDVKISNVIGGMRGLKAMIWEGSVLDANEGIRFHGRTIKDCQKELPKGTSGTEMLPEAMFWLLLTGKIPTTTQIRAFSRELAEKSYLPQHILDLFKSFPKDMHPMTQLAVAVGALNTESKFAKAYEKGLPKADYWEPTFDDSISLLAKIPRVAALVFRSNEIDAVANQKLDVTQDWSYNFAELLGKGGKENEDFHDLLRLYLALHGDHEGGNVSAHATHLVGSALSDPFLSYSAGLLGLAGPLHGLAAQEVLRWILAMQEEIGTKFTDKDVEDYLWSTLKSGRVVPGYGHGVLRKPDPRFEALMDYAATRPDVLANPVFQLVKKNSEIAPGVLTKHGKTKNPHPNVDAASGVLFHHYGFHQPLYYTVTFGVSRALGPLAQLIWSRALGLPIERPKSINLLGLVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5A9</accession>
    <name>B8M5A9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine racemase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_029860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480149.1">
        <property type="nucleotide sequence ID" value="XM_002480104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5A9"/>
    <dbReference type="STRING" id="441959.B8M5A9"/>
    <dbReference type="GeneID" id="8106553"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_029860"/>
    <dbReference type="eggNOG" id="KOG1251">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021152_4_2_1"/>
    <dbReference type="InParanoid" id="B8M5A9"/>
    <dbReference type="OMA" id="IRHHIYQ"/>
    <dbReference type="OrthoDB" id="7773036at2759"/>
    <dbReference type="PhylomeDB" id="B8M5A9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF6">
        <property type="entry name" value="L-THREONINE DEHYDRATASE CATABOLIC TDCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="4">
        <location>
            <begin position="6"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED19715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="293" mass="30870" checksum="D9106708BF98B7D2" modified="2009-03-03" version="1">MKKLAMRQAYGAEVLFKAENFPITGSFKLRGALSKLTTQLAEERLITASSGDHGIEAAFASRALSKSLIVVLPAKLERIKSYGVDVILHGTETGLAEQHAQQLVASRDYSYISPYNDIDIIAGQGTIGLEIIEQCNKVDNVFISMGGGGLISGVGSVFKAFSPRTKVYGIAAVNSKALAASVAAGRAVETEHLPTLAEAVAGGIDGDTITLPLATSMIGHIIECEEEDVLETLEALSFDENMIVKDSAALALAGFNKVAQARDLTGQTNVVLLCGANVGPDIIRKAIYSSKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5K3</accession>
    <name>B8M5K3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTPase activating protein (Gyp3), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_031560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480331.1">
        <property type="nucleotide sequence ID" value="XM_002480286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5K3"/>
    <dbReference type="STRING" id="441959.B8M5K3"/>
    <dbReference type="GeneID" id="8107767"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_031560"/>
    <dbReference type="eggNOG" id="KOG2058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005350_3_1_1"/>
    <dbReference type="InParanoid" id="B8M5K3"/>
    <dbReference type="OMA" id="TDEWPTT"/>
    <dbReference type="OrthoDB" id="44736at2759"/>
    <dbReference type="PhylomeDB" id="B8M5K3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="520"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
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            <end position="407"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED19897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="868" mass="97066" checksum="A4FDD4F83F81DE53" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
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            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
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        <property type="entry name" value="MEAB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leucine zipper domain"/>
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    </dbReference>
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        <property type="entry name" value="BZIP_BASIC"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
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        <location>
            <begin position="148"/>
            <end position="283"/>
        </location>
    </feature>
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        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
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        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
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        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
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        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED19942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="410" mass="45538" checksum="68FF278AA6925219" modified="2009-03-03" version="1">MVSAVDTRPMNDHDMSMDTVVPKTEVAQDGHVSMSSSVSTPEPEEQSQDVAQTQKRKGGRKPIYATSEERKQRNRQAQAAFRERRTEYIKQLETTIKRNEESLQSLQQSHRSAADECLMLRYKNSLLERILMEKGIDVQAELRLKTGNSSTIPPIKLNANTLAPKQPLPLDRAAIGRSSTQRRPTSGAIAPKPDHSGLPQSRDSVYSATSPQPQPTPSSHVSSPSTGRSPGFALQGAMSPKGTDFQSQQRNRPPLLPHPRDFTQQNPLGVNQMRPMDPYAATTQPMIPGATMTSHMQSYYSAPFQKHYDQLEQEYDAQADMLDDTENHENGSEANTYVPDFNRPPVPTGQGRMGLPGPSSMQTGDDQGMYNAGGSLFNQYEPVLDSDTFGLSASMHFQTPFSYEQEMLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6A7</accession>
    <name>B8M6A7_TALSN</name>
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        <recommendedName>
            <fullName evidence="2">GTPase-activating protein GYP7</fullName>
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    </protein>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Trichocomaceae</taxon>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002479671.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="B8M6A7">
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    </dbReference>
    <dbReference type="STRING" id="441959.B8M6A7"/>
    <dbReference type="GeneID" id="8108009"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_025970"/>
    <dbReference type="eggNOG" id="KOG2197">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004457_0_0_1"/>
    <dbReference type="InParanoid" id="B8M6A7"/>
    <dbReference type="OMA" id="WWREQRG"/>
    <dbReference type="OrthoDB" id="10264062at2759"/>
    <dbReference type="PhylomeDB" id="B8M6A7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TBC1 domain family member 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021935">
        <property type="entry name" value="SGSM1/2_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF502">
        <property type="entry name" value="SMALL G PROTEIN SIGNALING MODULATOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12068">
        <property type="entry name" value="PH_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="440"/>
            <end position="668"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
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            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="737"/>
            <end position="779"/>
        </location>
    </feature>
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        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="740"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00072091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00082648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED19282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="807" mass="92136" checksum="A5AAC35AFA8CEAC8" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6Y3</accession>
    <name>B8M6Y3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit SPC19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Outer kinetochore protein SPC19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_034420</name>
    </gene>
    <organism evidence="15 16">
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        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex SPC19 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480637.1">
        <property type="nucleotide sequence ID" value="XM_002480592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6Y3"/>
    <dbReference type="FunCoup" id="B8M6Y3">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M6Y3"/>
    <dbReference type="GeneID" id="8104284"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_034420"/>
    <dbReference type="eggNOG" id="ENOG502SDEQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112993_0_0_1"/>
    <dbReference type="InParanoid" id="B8M6Y3"/>
    <dbReference type="OMA" id="DCCEEAH"/>
    <dbReference type="OrthoDB" id="3361333at2759"/>
    <dbReference type="PhylomeDB" id="B8M6Y3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="InterPro" id="IPR013251">
        <property type="entry name" value="DASH_Spc19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08287">
        <property type="entry name" value="DASH_Spc19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="133"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED20203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="168" mass="18976" checksum="7D1D9EE5BAC8B866" modified="2009-03-03" version="1">MVDSLSSSVTSLRTSLQLLESSIDILDTGVNDFPRLSKVLQTTRHFELLPEPTLQEAQQSLLDEITPSIAHLLSITTNHVERLARREDSLRAKCQLQEGRLSDERRDPNSTTKTAVASRAGERSDAGAKAAQLRRLVQKKERLKYAVDRLELQSRQKERELRKSMAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7X2</accession>
    <name>B8M7X2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_031140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480285.1">
        <property type="nucleotide sequence ID" value="XM_002480240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7X2"/>
    <dbReference type="GeneID" id="8107725"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_031140"/>
    <dbReference type="eggNOG" id="KOG3098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030884_1_0_1"/>
    <dbReference type="InParanoid" id="B8M7X2"/>
    <dbReference type="OMA" id="NIDESHQ"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="PhylomeDB" id="B8M7X2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF55">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED19851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="53276" checksum="4CB9503533B8CFE3" modified="2009-03-03" version="1">MSGLSPTAASANSAVTCISSSSTETLNAEEVMATNAAQLAIDEETPPPALYRIYSNPWFQILLISGICFCCPGMYNALTGIGGSGQVDPTVAANATVALLSAMAVTSLFIVGPVFNQFGPRACLLLGGWAYPLYSGALLSFNKNGNGAFVIVAGAILGIGASFVWVSQGAIMTTYVPEQQKGRAIALFWVIFNLGGGVGSLASLGLNYRSTTGTVSDATYVSLLVIMTIGWLLGVFICPPSSVRNHNNIDESHQKSPVKLLDVCLKMSSDWRILCMIPLFFSANVFYSYQQNEVNGRSFNIRTRSLNGALYWLAQMVGGLVMGLLLDLPGLSRPQRARLGWIFLFCTGMCIWGGGYAFQKWSSHRINEKHLKQDIDFTWRSVSVGPMFLYSFYGAYDAFWQSFCYWLIGAQSNSATVTAILVCAYKAFQSVGGAIAWRINALEVSPVVQFFMDWGLCIGSLVLVIPTVLAVTLTTADVDPPSTEEKVEDSSAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8M838</accession>
    <name>B8M838_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BAG domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_032550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480434.1">
        <property type="nucleotide sequence ID" value="XM_002480389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M838"/>
    <dbReference type="STRING" id="441959.B8M838"/>
    <dbReference type="GeneID" id="8099868"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_032550"/>
    <dbReference type="eggNOG" id="ENOG502S9SN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032998_0_0_1"/>
    <dbReference type="InParanoid" id="B8M838"/>
    <dbReference type="OMA" id="MSWRNPL"/>
    <dbReference type="OrthoDB" id="417450at2759"/>
    <dbReference type="PhylomeDB" id="B8M838"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00264">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="100"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="BAG" evidence="3">
        <location>
            <begin position="243"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED20000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="326" mass="36294" checksum="91EF2DC9300D52AF" modified="2009-03-03" version="1">MSWRDTFGIFRRSSSNYGHNAQGAPPQVSDSDYSYLTNDDIVAPPRTYQQQSHNDGRRVLRPGVNYPAEDESPDILLLKHRGVTYPLHFPAYAIDDGVLTVGAIRRRAAEQTGTSDLNRIKILYKGKLLRDDNKPCKDEGLRQQSEVISLSGSEALSLDSRSTDHRHQSPPSGSGGVKKKGNKKKKKKHDQQHLAPEPRPVETRHSNDNLAPPSDARPTSSGRSSAAPSPSPRLQQFSTPNERVEALLRYLRTELAPLCEKYFSNPPTDPKARDYEHKLLNETILSQVILKADGIDSEEARPARRALIKEAQGLLNKLDALAPQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8G6</accession>
    <name>B8M8G6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_037000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480913.1">
        <property type="nucleotide sequence ID" value="XM_002480868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8G6"/>
    <dbReference type="STRING" id="441959.B8M8G6"/>
    <dbReference type="GeneID" id="8100546"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_037000"/>
    <dbReference type="eggNOG" id="ENOG502TAG6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038614_0_0_1"/>
    <dbReference type="InParanoid" id="B8M8G6"/>
    <dbReference type="OMA" id="VIDNICM"/>
    <dbReference type="OrthoDB" id="5426109at2759"/>
    <dbReference type="PhylomeDB" id="B8M8G6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="58315" checksum="F45D8156513A0342" modified="2009-03-03" version="1">MAATLIRNTPNPLLLPEIVEYVIDNICMGDLVSCACVNSLWNVIALKKLYKGSLNDMLNVSFDRKVAALSESSRDNKLLFHLIRSCNLHFFHFEERSRDQMTPIEIAELLISLQRQQNLKALVLIIPGSSCSAAIRMARRKQSKLWPNLKALYLGMGDEHWLEQIPDFKELQILSIQEFISGPRIINSDVISKIGKCQELRVIDVYFRECNDIEALLDIAHGCPLLQMLRVLHRRLGGPLDPMNTKFSDLLCALPHLEFLELDLKFQINGAHIQDLAVHCPRLTVLRLRETWLCLSIAQMRTVDTLRQLELVQSKEVLFENPQRLMEPHIFSTLVAEWRRIFPKLREMPCHADIYGLDMKRGDLEEISERDVVSLSSYEEIPLSVLEDTEEYHSSETTESDMITLSSEEEISSDESEDAEEEEEEEEEEEEEEAVFPGEQELNYNYFGSDWVFLRIRLWRELRYGPSQTAYDRFASIWRTNLEIEKIGWPVMPLEAYSDPESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8J0</accession>
    <name>B8M8J0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="3">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_037230</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; D-xylose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="3"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480937.1">
        <property type="nucleotide sequence ID" value="XM_002480892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8J0"/>
    <dbReference type="STRING" id="441959.B8M8J0"/>
    <dbReference type="GeneID" id="8100569"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_037230"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="InParanoid" id="B8M8J0"/>
    <dbReference type="OMA" id="MVNQIFL"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="PhylomeDB" id="B8M8J0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="12">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED20503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="312" mass="34313" checksum="197576EC9FA40B7C" modified="2009-03-03" version="1">MALADKRYKLNTGAEIPALGLGTWQSTPEETQRAVYHAIKVGYRHIDTALAYSNEVDVGKGIKAAIDDGLVKREDLFVTTKLWCVYANRVEEGLDTSLKALGLDYVDLYLVHWPVRMNENGNHPLFPKLPDGTRDIIHSHNHISTWKAMEKLPSTGKVKAVGVSNYSVPYLKALLAEASIVPAANQIENHPQLAQQEIVDFCQEKGILIEAYSPLGSTGSPLFTAEPVVEIAKKMGVSPATVLLSWHLARGSVVLAKSINPDRITANRELVDLDAEDVVLLQKYADDLKASGKSKRYVAPPFGVDMGFPDKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8N3</accession>
    <name>B8M8N3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Putative lipase ATG15</fullName>
            <ecNumber evidence="6">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Autophagy-related protein 15</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Putative lipase atg15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">TSTA_037640</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480981.1">
        <property type="nucleotide sequence ID" value="XM_002480936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8N3"/>
    <dbReference type="FunCoup" id="B8M8N3">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M8N3"/>
    <dbReference type="GeneID" id="8102140"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_037640"/>
    <dbReference type="eggNOG" id="KOG4540">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028295_0_1_1"/>
    <dbReference type="InParanoid" id="B8M8N3"/>
    <dbReference type="OMA" id="TYHFGHT"/>
    <dbReference type="OrthoDB" id="58570at2759"/>
    <dbReference type="PhylomeDB" id="B8M8N3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034496">
        <property type="term" value="P:multivesicular body membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046461">
        <property type="term" value="P:neutral lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000129">
        <property type="entry name" value="Autophagy related lipase Atg15, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
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        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0072">Autophagy</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="21" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002874846" description="Putative lipase ATG15" evidence="21">
        <location>
            <begin position="32"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="22">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00019241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00029828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EED20547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="606" mass="65802" checksum="4042464F55FCE76E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8T5</accession>
    <name>B8M8T5_TALSN</name>
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        <recommendedName>
            <fullName evidence="6">Oxidase ustYa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_038090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
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        <property type="protein sequence ID" value="EED20598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002480987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8T5"/>
    <dbReference type="STRING" id="441959.B8M8T5"/>
    <dbReference type="GeneID" id="8102184"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_038090"/>
    <dbReference type="eggNOG" id="ENOG502SP97">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042941_1_1_1"/>
    <dbReference type="InParanoid" id="B8M8T5"/>
    <dbReference type="OMA" id="PFHYATE"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="PhylomeDB" id="B8M8T5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF6">
        <property type="entry name" value="OXIDASE USTYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED20598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="36577" checksum="EEA05DB52B311BA8" modified="2009-03-03" version="1">MSSKEDIYRENDRDSESVHEGEYDGLVSGTPRRPIVDRKFSKASKLVSGFLIISVLLNVAQLFLFVVCKPKFYSQYAHLPENELEIPFHYATEYSDDQHTHEEKDALWNAIDISEGFVAITHEEADKLGLPRSKVFPWDANKGMYVSHGHHALHCTVLLHAFTYDAHIGKKPKVSYHHIEHCLDLLRQDIMCRADDLMDFTKDHGDEFLTGEGQVRKCRDWNKLSKWVQERTACYKTINITRAGEDHGVAHQLDRYTYCPPGSPYEPLIRAFKDLGRVNPGNLDENSIEKLSPEELKADAEAVAEHNNAILNAENNKTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8U8</accession>
    <name>B8M8U8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_038220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481045.1">
        <property type="nucleotide sequence ID" value="XM_002481000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8U8"/>
    <dbReference type="STRING" id="441959.B8M8U8"/>
    <dbReference type="GeneID" id="8102197"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_038220"/>
    <dbReference type="eggNOG" id="KOG0502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_324175_0_0_1"/>
    <dbReference type="InParanoid" id="B8M8U8"/>
    <dbReference type="OMA" id="SAFQEAW"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="PhylomeDB" id="B8M8U8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="329"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="807"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="901"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="914"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED20611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="923" mass="106012" checksum="357F4305EC8E654B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9L4</accession>
    <name>B8M9L4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_117880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482008.1">
        <property type="nucleotide sequence ID" value="XM_002481963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9L4"/>
    <dbReference type="GeneID" id="8105846"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_117880"/>
    <dbReference type="HOGENOM" id="CLU_1741793_0_0_1"/>
    <dbReference type="InParanoid" id="B8M9L4"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="16549" checksum="00C4365B86D7518A" modified="2009-03-03" version="1">MASKKGIYIPIKPISATSPSQQPFYAPCLNLSYFESPGIAGLGWIGPMRSEDGGDFHEYKRAGAAGQMINPSRRKGFGAEALKMVVDYGLNVLELAKVKIGTTLSNMTMARLVEARFKMEAEAEEIGDRFGSDLLSRIGKERWGHYLEEE</sequence>
</entry>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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                <person name="Fedorova-Abrams N.D."/>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        </subcellularLocation>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_118950"/>
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    <dbReference type="InParanoid" id="B8M9X9"/>
    <dbReference type="OrthoDB" id="2433935at2759"/>
    <dbReference type="PhylomeDB" id="B8M9X9"/>
    <dbReference type="Proteomes" id="UP000001745">
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
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            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
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        <location>
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            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="393"/>
        </location>
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            <end position="492"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="690" mass="75655" checksum="368A57F68C587E61" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
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    </organism>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
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    <dbReference type="PhylomeDB" id="B8MAE5"/>
    <dbReference type="Proteomes" id="UP000001745">
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    </dbReference>
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        <location>
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            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="659" mass="74193" checksum="5A17D6CF6408F30A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAS5</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
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    <dbReference type="AlphaFoldDB" id="B8MAS5"/>
    <dbReference type="GeneID" id="8099587"/>
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    <dbReference type="HOGENOM" id="CLU_2623683_0_0_1"/>
    <dbReference type="InParanoid" id="B8MAS5"/>
    <dbReference type="Proteomes" id="UP000001745">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED17765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="78" mass="8465" checksum="74CC670387A66A25" modified="2009-03-03" version="1">MPTPARAVNLRKLEPKIDSSRVAAVVAANGRDEQCKGASCMADDVRLRTARVSPYARRAAIYDAYDWTSFNAPLAAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBA3</accession>
    <name>B8MBA3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_126030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482884.1">
        <property type="nucleotide sequence ID" value="XM_002482839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBA3"/>
    <dbReference type="GeneID" id="8098115"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_126030"/>
    <dbReference type="HOGENOM" id="CLU_155384_0_0_1"/>
    <dbReference type="InParanoid" id="B8MBA3"/>
    <dbReference type="OMA" id="IRTRCPT"/>
    <dbReference type="OrthoDB" id="4369213at2759"/>
    <dbReference type="PhylomeDB" id="B8MBA3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="11537" checksum="A3D159B2F418C168" modified="2009-03-03" version="1" fragment="single">AYELTVNDLLLVRKENHDLRAAHEKEKEKRQISKKQISTEQGITREEAQALVQSQVEASQAVTTTPGEPELPASQPVVRRQFRCSGCGVEGHKITRCPNRTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBM1</accession>
    <name>B8MBM1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conidial pigment biosynthesis protein Ayg1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_116740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481877.1">
        <property type="nucleotide sequence ID" value="XM_002481832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBM1"/>
    <dbReference type="STRING" id="441959.B8MBM1"/>
    <dbReference type="ESTHER" id="talsn-b8mbm1">
        <property type="family name" value="Duf_1100-S"/>
    </dbReference>
    <dbReference type="GeneID" id="8102066"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_116740"/>
    <dbReference type="eggNOG" id="ENOG502S29V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053723_1_0_1"/>
    <dbReference type="InParanoid" id="B8MBM1"/>
    <dbReference type="OMA" id="NDHEYPF"/>
    <dbReference type="OrthoDB" id="5409895at2759"/>
    <dbReference type="PhylomeDB" id="B8MBM1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000145">
        <property type="entry name" value="Pigment biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010520">
        <property type="entry name" value="FrsA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF12">
        <property type="entry name" value="CONIDIAL PIGMENT BIOSYNTHESIS PROTEIN AYG1 (AFU_ORTHOLOGUE AFUA_2G17550)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06500">
        <property type="entry name" value="FrsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="413" mass="46512" checksum="A222199A72FA5EF5" modified="2009-03-03" version="1">MINWILGDKFYAIYPHKNSIKGLWESKWEAACLKAVYPFHDGAFEDFKPIFETLIAENINDAYTDEYTNAFLPTAKALETKAFEAAERGIWDKAAEYYRRAAVVYRISRFPYVSTITEGNTVTSPLKRAAFDRQKEVYLKAASTWSPPINEVIIPHKYRAGKDGETIPLLIRIPQQADITNQVPVVLLMTGLDGYRCDNSQRTHELVGRGWATVICEIPGTADCPADPADPESVDRLWNSVLAYIASRPEFNLKKIAAWGLSAGGYYAVRAASTHRNQFLGCVAHGPGTHHFLSEKWLERIDDHEYPFIISKAMAEKFGFQNVEDFIKDGQNKFSLLENGIVKKPSCRLLLLNGIDDGVVPIEDSLILFNHGSPKEGRFVEKLAHMGYPDTLAVAYEWFENLLTKGDNPGLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MC67</accession>
    <name>B8MC67_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase, 2-nitropropane dioxygenase family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_122460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482505.1">
        <property type="nucleotide sequence ID" value="XM_002482460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MC67"/>
    <dbReference type="STRING" id="441959.B8MC67"/>
    <dbReference type="GeneID" id="8097711"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_122460"/>
    <dbReference type="eggNOG" id="ENOG502QTWN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038732_2_0_1"/>
    <dbReference type="InParanoid" id="B8MC67"/>
    <dbReference type="OMA" id="RAKPKAW"/>
    <dbReference type="OrthoDB" id="10265891at2759"/>
    <dbReference type="PhylomeDB" id="B8MC67"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF31">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED18513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="355" mass="37821" checksum="09B7876451D16AAA" modified="2009-03-03" version="1">MASPQVLRTPVTDLLKINHPVLLAGMNVAAGPKLAAAVTNAGGLGVIGGIGYTPEMLREQLNELKGYLNDKNAPFGVDLLLPQVGGNARKTNHDYTKGKLNELIDIIIESGAKLFVCAVGVPPKHVVEKLHKAGVLYMNMIGHPKHVKKCLDLGVDIICAQGGEGGGHTGDVPTTVLIPTVAKLVQGHKSPLTGAPVQVIAAGGLFNGQSVAAALMLGASAVWIGTRFILSDEAGASEAHKEAVRTAGFDDNVRTIIFTGRPLRVRNNSYIQNWEENRQQEIKELTSKGIIPVEHDFENLPDDVDEEVLDNARPFLMGKVSAVVTEKKPAKAIVDELVTDAAAWLQKGNKMIAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCF4</accession>
    <name>B8MCF4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Adenylyltransferase and sulfurtransferase uba4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Common component for nitrate reductase and xanthine dehydrogenase protein F</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin-like protein activator 4</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="14">Molybdopterin-synthase adenylyltransferase</fullName>
                <ecNumber evidence="14">2.7.7.80</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="14">Adenylyltransferase uba4</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="14">Sulfur carrier protein MOCS2A adenylyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="14">Molybdopterin-synthase sulfurtransferase</fullName>
                <ecNumber evidence="14">2.8.1.11</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="14">Sulfurtransferase uba4</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="14">Sulfur carrier protein MOCS2A sulfurtransferase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="14" type="primary">uba4</name>
        <name evidence="14" type="synonym">cnxF</name>
        <name evidence="17" type="ORF">TSTA_124890</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and MOCS2A. Its N-terminus first activates urm1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards urm1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; nfs1 probably acting as a sulfur donor for thiocarboxylation reactions.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and mocs2a. Its N-terminus first activates urm1 and mocs2a as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and mocs2a to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as a nucleophile towards urm1 and mocs2a. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; nfs1 probably acting as a sulfur donor for thiocarboxylation reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) = [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:43616"/>
            <dbReference type="Rhea" id="RHEA-COMP:12159"/>
            <dbReference type="Rhea" id="RHEA-COMP:12202"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="EC" id="2.7.7.80"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] + AH2 = [molybdopterin-synthase sulfur-carrier protein]-C-terminal-Gly-aminoethanethioate + L-cysteinyl-[cysteine desulfurase] + A + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48612"/>
            <dbReference type="Rhea" id="RHEA-COMP:12157"/>
            <dbReference type="Rhea" id="RHEA-COMP:12158"/>
            <dbReference type="Rhea" id="RHEA-COMP:12159"/>
            <dbReference type="Rhea" id="RHEA-COMP:19907"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:232372"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.80" evidence="14"/>
    <dbReference type="EC" id="2.8.1.11" evidence="14"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482762.1">
        <property type="nucleotide sequence ID" value="XM_002482717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCF4"/>
    <dbReference type="FunCoup" id="B8MCF4">
        <property type="interactions" value="862"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MCF4"/>
    <dbReference type="GeneID" id="8100268"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_124890"/>
    <dbReference type="eggNOG" id="KOG2017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_1_2_1"/>
    <dbReference type="InParanoid" id="B8MCF4"/>
    <dbReference type="OMA" id="IPDVGMD"/>
    <dbReference type="OrthoDB" id="10261062at2759"/>
    <dbReference type="PhylomeDB" id="B8MCF4"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061605">
        <property type="term" value="F:molybdopterin-synthase adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061604">
        <property type="term" value="F:molybdopterin-synthase sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042292">
        <property type="term" value="F:URM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007114">
        <property type="term" value="P:cell budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000220">
        <property type="term" value="P:regulation of pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000014">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000033">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03049">
        <property type="entry name" value="MOCS3_Uba4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028885">
        <property type="entry name" value="MOCS3/Uba4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF102">
        <property type="entry name" value="ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 14" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rhodanese" evidence="16">
        <location>
            <begin position="357"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate; for adenylyltransferase activity" evidence="14">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate; for sulfurtransferase activity" evidence="14">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="118"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="179"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EED18770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="471" mass="51624" checksum="F66066E5B7C1F950" modified="2009-03-03" version="1">MEDIDTKCTAIRAQITATESQLAALKEELEAAERLRGASAPTSSKHSERKWPLSAEEYQRYGRQMIVSQIGLPGQLKLRSASVLLVGAGGLGCPAALYLAGAGVGTVGMVDGDTVEASNLHRQVLHRTKNVGKYKVDSAIEYLEELNPHPKYCAHREHLSPQNAPGIFQNYDIILDCTDNPATRYLISDTAVLLGKPLVTASALRTDGQLMVLNNPPKPPGDLSGGPCYRCVFPKPPPADTVVSCADGGILGPVVGTMGVLQALETIKVLVKSVDQSSDDRPSLHIFSAYSNPPFRTIRLRGRRTNCAVCSSEPTITLSTLQSGSTDYVQFCGSARFPQVLSKDERVSVREFEPIYDSKKYSLIDVRDPVQFGICNLENSINIPITQILQDRTFDNKDPKETLRSLLPPELTSTDSTDPIYFVCRMGNDSQLAVQKLRQLGFDQDGRRFIGDIRGGLKAWKAEVDPEWPEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCL0</accession>
    <name>B8MCL0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pogo transposable element, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_125400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482818.1">
        <property type="nucleotide sequence ID" value="XM_002482773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCL0"/>
    <dbReference type="GeneID" id="8100319"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_125400"/>
    <dbReference type="eggNOG" id="ENOG502S2ZX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_4_0_1"/>
    <dbReference type="InParanoid" id="B8MCL0"/>
    <dbReference type="OrthoDB" id="3562866at2759"/>
    <dbReference type="PhylomeDB" id="B8MCL0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="3">
        <location>
            <begin position="17"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="166"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED18826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="508" mass="57919" checksum="9C4B40016334DEDC" modified="2009-03-03" version="1">MPPIRNKNRKNLDEQEGRILLAISDLQNGRIQRVAQAARIYEIPRTTLQDRLNGIQQRSLVRANSHKLTQYEEESLVKWVLDLDRRGLPPGILLKYNYERAKCEDPKIIQEHFDRVQAAISEYGILPEDIFNFDETGFAMGLCATAKVITGSDRYAQPKLLQPGNREWVTAIEATNSTGWAVPSYVIFKAKKNVREGWFDDLPDDWRINISDNGWTTDQIGLEWLKTHFIPYINGRTVGKYRMLILDGHGSHLTPEFDHICTENNIIPVCMPPHSSHLLQPLDVGCFAVLKRHYGQLVEQRMRLGFNHIDKMDFLTAFPQARTVAYKAQTIRNSFAATGLVPFNPDRTPTPPPSRSSNTASSCLQTPQNIRQFIRQSTTINKRINERTESNQNQEINQAVVRLSKAYEMIANDVLLVRKENYDLRAAHEKEKQKRQKSKKQISIEQAVTKEEVQALVQGQVEASHAVTTTPAEPELPASQAVVRRQYRCSGCNVMGHRINQCPSRISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B8MD47</accession>
    <name>B8MD47_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_113880</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481564.1">
        <property type="nucleotide sequence ID" value="XM_002481519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MD47"/>
    <dbReference type="FunCoup" id="B8MD47">
        <property type="interactions" value="261"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MD47"/>
    <dbReference type="GeneID" id="8101700"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_113880"/>
    <dbReference type="eggNOG" id="KOG0425">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_1_1_1"/>
    <dbReference type="InParanoid" id="B8MD47"/>
    <dbReference type="OMA" id="FQAHIKF"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="PhylomeDB" id="B8MD47"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010828">
        <property type="term" value="P:positive regulation of D-glucose transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23811">
        <property type="entry name" value="UBCc_ScCDC34-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000063">
        <property type="entry name" value="CDC34p Ubiquitin-conjugating enzyme (E2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="38"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="171"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="244"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED17572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="275" mass="31282" checksum="7959D19AF4693535" modified="2009-03-03" version="1">MSRPLNLQFRHSAITRHLACCHLQHHTPLHFCVASDIMAERILMNEFKALSKEKWVNIELKSEDIFCWKVALIVLNPDSLYYGGYFKAVMEFPKNYPYSPPKFRFHRPIWHPNIYTDGKLCISILHTPGEDEQSGELAAERWSPAQRVESVLISILSLLDDAECSSPANVDAGVQLRKDPKGYREHVRQDVESSKQDIPDGFVMPTFESTLSKPTEKDDADKEDLDFWADSDVDDDPFGGSDSSDVDMDEDDDDEMGSLDEDDDEEDNETDGDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDN8</accession>
    <name>B8MDN8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_120170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482259.1">
        <property type="nucleotide sequence ID" value="XM_002482214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MDN8"/>
    <dbReference type="GeneID" id="8105291"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_120170"/>
    <dbReference type="eggNOG" id="ENOG502SA85">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074427_0_0_1"/>
    <dbReference type="InParanoid" id="B8MDN8"/>
    <dbReference type="OMA" id="RNLASCI"/>
    <dbReference type="OrthoDB" id="5371646at2759"/>
    <dbReference type="PhylomeDB" id="B8MDN8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="352" mass="38180" checksum="DEEC5CCCF39C1A52" modified="2009-03-03" version="1">MSDQHGRDWTEEEKYALLTVILRNSGVPSTSLFGIFRQFNVSPPWPDMPLPPGRSLNECRQQFESMWQTHQSQPSYRQPEPWQGPLPPAAFPAMNPGPAHAPPHQAPHDAFGSRKRPFYPPERPPAFPRAIQPRPPLSGGQFSSESGSPAPTSPGWVEGAAGKSAEPPRKRGRPSKAESERRKAEAEARGETYPAPRRRTSMGKLPATPSGAASATSDSSMVSPMQTAQTPEMPKQDKGPEAPVSTGQATRASPLTSEVPDTDPVRGIIRSQANQDRRLPLPHEFGARTSPPESIYSHTRAMEHPYHGLSTSRPEENTTQPTTARQIIQHSEAPTSGGGYLPAISHSAGATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDQ5</accession>
    <name>B8MDQ5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysM domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_120330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
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            <end position="290"/>
        </location>
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        </location>
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            <end position="190"/>
        </location>
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        <location>
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            <end position="352"/>
        </location>
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        <location>
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            <end position="473"/>
        </location>
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        <location>
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            <end position="497"/>
        </location>
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            <end position="626"/>
        </location>
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            <begin position="15"/>
            <end position="28"/>
        </location>
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        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
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            <begin position="62"/>
            <end position="73"/>
        </location>
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        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
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        <location>
            <begin position="108"/>
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        </location>
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            <end position="348"/>
        </location>
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        <location>
            <begin position="413"/>
            <end position="427"/>
        </location>
    </feature>
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            <end position="612"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED18284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="626" mass="67499" checksum="8968FF05CA38FA32" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEA8</accession>
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        <submittedName>
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        <name evidence="2" type="ORF">TSTA_016140</name>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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            <end position="144"/>
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    </feature>
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            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="144" mass="15097" checksum="EADAF4A40E967E1D" modified="2009-03-03" version="1">MSGDNSRRGGTLSEMAPTGTTIPNDAGLQNTIPSKARPDQQSEDHRFSYDGLAQSSVATAADNATDMPRSTRDVGQTGEVMTGTGDSLPAEIETKNLSIQTNDPGAKGQTRTLKHAVKNRGAFDKLVGDDPEGAQAVGEPEQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEB6</accession>
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        <submittedName>
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        </lineage>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
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            <dbReference type="PubMed" id="25676766"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    <dbReference type="eggNOG" id="ENOG502S1BG">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_11_1_1"/>
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    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="PhylomeDB" id="B8MEB6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052370">
        <property type="entry name" value="Meta-cleavage_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43139:SF65">
        <property type="entry name" value="HYDROLASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SI:DKEY-122A22.2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="106"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="408" mass="43981" checksum="71A55B8812EB91CE" modified="2009-03-03" version="1">MVLGFFKQTADFVTDSVTSPQTQRPFLAVAGTSITLGLALGAIWAFERSPPKIIPSPLKAVQSAALNKDGELPVLPLDVLPGARDVSTPYGSIRVYEWGPEDGHKVLLVHGISTPCVSLGGLAHSLVDRGCRVMTFDLFGRGFSDTPGDIPQDDRLFSTQILLALASSPLSWTGSSSGKFSLIGYSLGGGITAAFASHFHDLLSSLVLLAPAGLMRESHVGWQTRLLNAKGLLPESVISSLVKGRLKAGPLVKPKKDNGSQNETVGVEAALTEELTASPQQVLSRTYPSLKTAEAVAWQIENHDGFIPAFISSMRHGPILQKSQLDNWKRLGSFLSQRKREGAGTGLAHDKVLVVLGETDNVIFKDDTVEDVTHALEGNAQITYFDIGHEFPSVKYEELATQLIEFWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEQ2</accession>
    <name>B8MEQ2_TALSN</name>
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        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_019940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002484124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEQ2"/>
    <dbReference type="FunCoup" id="B8MEQ2">
        <property type="interactions" value="236"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MEQ2"/>
    <dbReference type="GeneID" id="8108805"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_019940"/>
    <dbReference type="eggNOG" id="ENOG502S2DH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015493_4_0_1"/>
    <dbReference type="InParanoid" id="B8MEQ2"/>
    <dbReference type="OMA" id="VRCDTQK"/>
    <dbReference type="OrthoDB" id="5069333at2759"/>
    <dbReference type="PhylomeDB" id="B8MEQ2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED16935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="583" mass="66035" checksum="9EFFEFCA6CE41365" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFM8</accession>
    <name>B8MFM8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_020750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484252.1">
        <property type="nucleotide sequence ID" value="XM_002484207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFM8"/>
    <dbReference type="STRING" id="441959.B8MFM8"/>
    <dbReference type="GeneID" id="8109337"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_020750"/>
    <dbReference type="eggNOG" id="KOG1807">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_698642_0_0_1"/>
    <dbReference type="InParanoid" id="B8MFM8"/>
    <dbReference type="OMA" id="DICQARI"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="PhylomeDB" id="B8MFM8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED17018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="395" mass="45224" checksum="6BC7092AF7C67F18" modified="2009-03-03" version="1">MAPKGICREFAKSGTCKFKKCKFRHKKDDQMAPHTKENPSLLSNTLSNTEREFRAWKHSIPVNRKAAPTDGRLTSIFQKALQLIDSDVGVRQSVIQALSDESGLRCIQSMTEQNFERMPGSLEEQTFRTQILPLLKTISHADVLQSLILEQSVGTIYNFLFGVGGTRASKLLRFCSEVLMHCNKNESTMEWLEASLVVFSRIVDLNSAALIQESLKDCASQFQLIFTAWVTDHPDNPLHQSRLHLERLFHRFDIGISLPNMTQKKMSKGPRARGAFVFEHDPPGGRHDNDHRDICQIRIMPTFDEISSRRVEYLPTYDPAQWHVNGPHGLLDRNFRLLREDTVGLLRDAIQLEIQPPRTLSNHNPKQRTNVYQGGRIAKLGFHKMDGFQFKFDFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFS7</accession>
    <name>B8MFS7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_009190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483028.1">
        <property type="nucleotide sequence ID" value="XM_002482983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFS7"/>
    <dbReference type="STRING" id="441959.B8MFS7"/>
    <dbReference type="GeneID" id="8100780"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_009190"/>
    <dbReference type="eggNOG" id="ENOG502QVGN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_921898_0_0_1"/>
    <dbReference type="InParanoid" id="B8MFS7"/>
    <dbReference type="OrthoDB" id="407275at2759"/>
    <dbReference type="PhylomeDB" id="B8MFS7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF17">
        <property type="entry name" value="OXIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002875139" description="FAD-binding PCMH-type domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="38"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED15794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="302" mass="32022" checksum="0839D3853E349756" modified="2009-03-03" version="1">MAARLSTCLLAALASNHSVVVTPSSPNYNSSLTIYNLNIPILLAAVTYPSTTEEVAGVVKCAAEGNYKVQAKGGGHSYGNYGWGGESGEVVVNLANLNGYSYDNSTGYATVGAGSRLGSVTTSLYNLGKCAVAHGSYPDVGIGGHATIGGLDMVAIWANEAAAAERPAYFYAKSLDVMPNALLLNETIDSMFEHLTATPDDVLTYQLEGQLVSGAMAAVASNAMAFPHCDVLYWIFAYAVTNGTVSKTTIDFLDDFNDVIYSAFPNENFLCICRLRGPSTFEWTRTLLGRQPSAFGINQNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGC7</accession>
    <name>B8MGC7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_013490</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483481.1">
        <property type="nucleotide sequence ID" value="XM_002483436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGC7"/>
    <dbReference type="STRING" id="441959.B8MGC7"/>
    <dbReference type="GeneID" id="8099148"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_013490"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="InParanoid" id="B8MGC7"/>
    <dbReference type="OMA" id="TSRHIMM"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="PhylomeDB" id="B8MGC7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF21">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="43"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED16247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="539" mass="57984" checksum="79C2B70E4C0D9AF0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHP7</accession>
    <name>B8MHP7_TALSN</name>
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        <submittedName>
            <fullName evidence="10">Siderochrome-iron transporter, putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="10" type="ORF">TSTA_011380</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483262.1">
        <property type="nucleotide sequence ID" value="XM_002483217.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483263.1">
        <property type="nucleotide sequence ID" value="XM_002483218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHP7"/>
    <dbReference type="GeneID" id="8104980"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_011380"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012970_1_0_1"/>
    <dbReference type="InParanoid" id="B8MHP7"/>
    <dbReference type="OMA" id="KYECITA"/>
    <dbReference type="OrthoDB" id="4078873at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000335">
        <property type="entry name" value="Siderochrome iron transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000284">
        <property type="entry name" value="Siderophore iron transporter mirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF107">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="211"/>
        </location>
    </feature>
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        <location>
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            <end position="243"/>
        </location>
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        <location>
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            <end position="293"/>
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            <end position="327"/>
        </location>
    </feature>
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        <location>
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            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
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        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
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        <location>
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            <end position="459"/>
        </location>
    </feature>
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        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="576"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED16028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="588" mass="65231" checksum="6671522EB483CE2F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIK6</accession>
    <name>B8MIK6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">LEM3/CDC50 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_045570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485051.1">
        <property type="nucleotide sequence ID" value="XM_002485006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIK6"/>
    <dbReference type="FunCoup" id="B8MIK6">
        <property type="interactions" value="487"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MIK6"/>
    <dbReference type="GeneID" id="8107544"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_045570"/>
    <dbReference type="eggNOG" id="KOG2952">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025025_0_1_1"/>
    <dbReference type="InParanoid" id="B8MIK6"/>
    <dbReference type="OMA" id="IPWSMFN"/>
    <dbReference type="OrthoDB" id="340608at2759"/>
    <dbReference type="PhylomeDB" id="B8MIK6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED15098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="395" mass="43761" checksum="85F75843D182A4DB" modified="2009-03-03" version="1">MSQAAATRNEFQDDPDHHGSDDADKKKNRRPANTAFRQQRLRAWQPILTPRSVLPIFFVIGAIFAPLGGVLLWASEQVQEIIIDYTDCDTLAPISSTAALPAGRVSSSFKSSAQTSVTTWQRNETDTATKTTGCSLFFDIPEPLGPPVFLYYKLTDFYQNHRKYVQSLDTDQLKGVAVDNSTIHGSTCDPLTTDSATGKAYYPCGLIANSIFNDTISSPVLVNEETYDMTDRGIAWSSDKKIIKTTKYEPWQVVPPPNWRIKYPEYTADNFPDLGNDEAFMVWMRTAGLPTFSKLARRNDTTAMPAGQYRLDIQSSFNVTQYGGTKSIMISTRTVMGGKNSFMGIAYVVVGGICVVIGVLFTAANLIRPRKLGDHTYLTWNNEPSTGTATGHDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJB6</accession>
    <name>B8MJB6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sugar transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_041810</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484658.1">
        <property type="nucleotide sequence ID" value="XM_002484613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJB6"/>
    <dbReference type="FunCoup" id="B8MJB6">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="GeneID" id="8102958"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_041810"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="InParanoid" id="B8MJB6"/>
    <dbReference type="OMA" id="YELTAAW"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="PhylomeDB" id="B8MJB6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000023">
        <property type="term" value="P:maltose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000149">
        <property type="entry name" value="MFS transporter, SP family, general alpha glucoside:H+ symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="395"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="470"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="47"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED14705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="542" mass="60735" checksum="0AE91A04EEC77436" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJL9</accession>
    <name>B8MJL9_TALSN</name>
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        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_046720</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485172.1">
        <property type="nucleotide sequence ID" value="XM_002485127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJL9"/>
    <dbReference type="FunCoup" id="B8MJL9">
        <property type="interactions" value="887"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MJL9"/>
    <dbReference type="GeneID" id="8108036"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_046720"/>
    <dbReference type="eggNOG" id="KOG2732">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021763_1_0_1"/>
    <dbReference type="InParanoid" id="B8MJL9"/>
    <dbReference type="OrthoDB" id="3763at2759"/>
    <dbReference type="PhylomeDB" id="B8MJL9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="CDD" id="cd07387">
        <property type="entry name" value="MPP_PolD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.430:FF:000002">
        <property type="entry name" value="DNA polymerase delta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.50:FF:000006">
        <property type="entry name" value="DNA polymerase delta subunit 2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040663">
        <property type="entry name" value="DNA_pol_D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041863">
        <property type="entry name" value="PolD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18018">
        <property type="entry name" value="DNA_pol_D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA polymerase delta subunit OB-fold" evidence="12">
        <location>
            <begin position="48"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="11">
        <location>
            <begin position="224"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED15219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="545" mass="59971" checksum="D67C0EB1ECD04823" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJV2</accession>
    <name>B8MJV2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_042440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484722.1">
        <property type="nucleotide sequence ID" value="XM_002484677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJV2"/>
    <dbReference type="STRING" id="441959.B8MJV2"/>
    <dbReference type="GeneID" id="8103337"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_042440"/>
    <dbReference type="eggNOG" id="ENOG502SJVS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8MJV2"/>
    <dbReference type="OrthoDB" id="5420247at2759"/>
    <dbReference type="PhylomeDB" id="B8MJV2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42029">
        <property type="entry name" value="AN04G07800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42029:SF3">
        <property type="entry name" value="AN04G07800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="42002" checksum="0963373B1E581396" modified="2009-03-03" version="1">MGVPDSEKVTRPTEPDALVLEAWGQGLLVGALLVMFAITIANMRRRVLLHKLILAELFLAMFHGTWIFTHEPAYGWYLSVTAIGLNVSWSLHNVIAWMKNRPFLSCRVSAFYITTVILVQPYWVLEIYANFTYFNNINKIFIKTRPLEPLFRDPWWLFTTCSLFYVIKKQYDFSLFELIKVSPRFGVMLLSMCLSLAFTVFDILSVTNVFSSALPTGVEPFWKLSFIFKCLCDTVILDDFKTALDRMHNYWLRRMDPNLEIGPDEYTFSSMNPQSYRDGRRKSSLRDIEEETATLGLSVMNPAAKYATQPNSKTSVDTAEKQILQQQRTGSFAHLNYVNTPQSTKRVPVPVQVKTKESRSWYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJV9</accession>
    <name>B8MJV9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_042500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484729.1">
        <property type="nucleotide sequence ID" value="XM_002484684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJV9"/>
    <dbReference type="STRING" id="441959.B8MJV9"/>
    <dbReference type="GeneID" id="8103343"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_042500"/>
    <dbReference type="eggNOG" id="ENOG502RXFK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029045_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJV9"/>
    <dbReference type="OMA" id="VQSWAWY"/>
    <dbReference type="OrthoDB" id="3363151at2759"/>
    <dbReference type="PhylomeDB" id="B8MJV9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="51331" checksum="8B3CDCA2000EAF04" modified="2009-03-03" version="1">MVGLDLKLLRKHIVTPPTKYEQEYLIGFRGLLVIQAFLWMFLQTFAPSTVYASYDVGGPHAQVIVRKVFSVLFWNEYFLYGAFIFLSARSIAIPYFRDPTPAVIARSLLTRSLQLCIPVAICLAIVKGSITANALNTIKHFKYSTNNLSLPIPYQFPNALSYWNSVFNLFWTTHGFRSQSGSYAFPTQTLWMINAVYIQSYTVYMIMVIVPYTRPQWRVQFGILFVIAAWWCNSWAWYTVSGVLVCDMVMHMDLKQNALMGIPVQYRSLVWRSNDGKPRRIPTWFVGGLLLVGGLLMQYLWAAYRPDLFFSEWRIHSNPYTTGGLDERYLLDHISARDDVYITILGIFILLETYDVLQRVLQNKFLLFLGRRALSYFLLQSIFAYIVGIRVFEGLRSRHVPHDGAVMVALITCIAVTVPAAELFHRLIVVPSRYLSHNFYEFITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8ML30</accession>
    <name>B8ML30_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Maintenance of telomere capping protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_048860</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MTC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485399.1">
        <property type="nucleotide sequence ID" value="XM_002485354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ML30"/>
    <dbReference type="FunCoup" id="B8ML30">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8ML30"/>
    <dbReference type="GeneID" id="8100602"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_048860"/>
    <dbReference type="eggNOG" id="ENOG502S5TR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033723_0_0_1"/>
    <dbReference type="InParanoid" id="B8ML30"/>
    <dbReference type="OMA" id="WGTIDPQ"/>
    <dbReference type="OrthoDB" id="5573651at2759"/>
    <dbReference type="PhylomeDB" id="B8ML30"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051008">
        <property type="entry name" value="Telomere_Capping_Maintenance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057530">
        <property type="entry name" value="TIM-barrel_MTC6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35518:SF2">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35518">
        <property type="entry name" value="MAINTENANCE OF TELOMOERE CAPPING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25506">
        <property type="entry name" value="TIM-barrel_MTC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="MTC6 partial TIM-barrel" evidence="11">
        <location>
            <begin position="18"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED15446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="559" mass="61532" checksum="48D3CE67DBBDD411" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLJ0</accession>
    <name>B8MLJ0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ZIP metal ion transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_049600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485476.1">
        <property type="nucleotide sequence ID" value="XM_002485431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLJ0"/>
    <dbReference type="STRING" id="441959.B8MLJ0"/>
    <dbReference type="GeneID" id="8102121"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_049600"/>
    <dbReference type="eggNOG" id="KOG3907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028824_0_0_1"/>
    <dbReference type="InParanoid" id="B8MLJ0"/>
    <dbReference type="OMA" id="DDFPSIC"/>
    <dbReference type="OrthoDB" id="19859at2759"/>
    <dbReference type="PhylomeDB" id="B8MLJ0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="196"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED15523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="408" mass="43228" checksum="060AADDE7FD01A2C" modified="2009-03-03" version="1">MEGLFTLLVLSIVMAMTSFVVGALPLSFTLSPSQSRFISSLGMGILVGTALVIIIPEGVETLYSSQNYRSQSSLQTGGLDVRWQHKSSPAHILPPRTVPEIDALPGPVIPDGASSFGDAAAVPPKTPTKPGEVHALDIDRDMGAGDSHDHDHDHEDEDRALHAWIGISLVSGFILMYLIDKLPAFASPPKPRRTPYHISLDNLGGSGLRRNSSPTRDGGLLDQDNNNNNNNHAGHNTHSFAMTTGLVIHAAADGIALGASGSNSNLSFIIFLALLVHKAPAAFGLTSVLLKQGLSSRVAGRHLLVFSLAAPVGALLTFIIVHTLGSGFGSDEASNRWRTGVLLLFSAGTFLYVAMHTIQEITPPSTPSHSNGYADSRETPKHKGSIQDVAISVVGMILPLFLQIGHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLQ7</accession>
    <name>B8MLQ7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ATP-binding cassette transporter, putative</fullName>
            <ecNumber evidence="15">1.3.1.74</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_098850</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.74" evidence="15"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485867.1">
        <property type="nucleotide sequence ID" value="XM_002485822.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MLQ7"/>
    <dbReference type="GeneID" id="8099713"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_098850"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_5_1"/>
    <dbReference type="InParanoid" id="B8MLQ7"/>
    <dbReference type="OMA" id="YDHALHI"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="PhylomeDB" id="B8MLQ7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032440">
        <property type="term" value="F:2-alkenal reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002145">
        <property type="entry name" value="ABC transporter (MsbA subfamily)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF399">
        <property type="entry name" value="ABC TRANSPORTER ATNG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="367"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="850"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="883"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="958"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="985"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="251"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="567"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="852"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1164"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="782"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="790"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED13629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1405" mass="155891" checksum="23B892D4FF3A05B2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMH3</accession>
    <name>B8MMH3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pantothenate kinase, putative</fullName>
            <ecNumber evidence="5">2.7.1.33</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_099770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.33" evidence="5"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485965.1">
        <property type="nucleotide sequence ID" value="XM_002485920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMH3"/>
    <dbReference type="FunCoup" id="B8MMH3">
        <property type="interactions" value="768"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MMH3"/>
    <dbReference type="GeneID" id="8105420"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_099770"/>
    <dbReference type="eggNOG" id="KOG2201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011154_3_1_1"/>
    <dbReference type="InParanoid" id="B8MMH3"/>
    <dbReference type="OMA" id="WSKGAKQ"/>
    <dbReference type="OrthoDB" id="498611at2759"/>
    <dbReference type="PhylomeDB" id="B8MMH3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24123">
        <property type="entry name" value="ASKHA_NBD_PanK-II_Pank4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000115">
        <property type="entry name" value="Pantothenate kinase PanK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.510:FF:000005">
        <property type="entry name" value="Probable pantothenate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00555">
        <property type="entry name" value="panK_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF20">
        <property type="entry name" value="4'-PHOSPHOPANTETHEINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED13727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="447" mass="49864" checksum="069DE6BED46B2EA3" modified="2009-03-03" version="1">MMSPIQNHSTEADPSRPSLEDAIINPGAVKINVQGAYIVDDQPPTPESPAEEDGVVYERKDIRLPHHTSVVSHVAVDIGGSLAKLVYFTRELSSHSEGGRLNFIKFETERIDRCIDFIKQLKEDHERLNGAAPGELCVVATGGGAYKYYDKLKETLKVDISQEDEMDCLITGLNFFITEIPHEVFSYSETEPMKFAEPNTSVYPYLLVNIGSGVSMIKVSGPKEFQRVGGTHLGGGTFWGLMALLTGATSFDDMLAMADRGDNSSVDMLVGDIYGMDYNKIGLKSTAIASTFGKVLKLKRSAEQRAEDGSDLGEDPEDTPPVQFRHEDMSRSLLFAISNNIGQIAYLQSEKHQLKHIYFGGSFIRGHLQTMNTLSYAIKFWSKGEKQAYFLRHEGYLGAVGAFLKRQPHNWGRRNSVDEASAATQFRENLAQEIKQTRQTEQEKQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMN9</accession>
    <name>B8MMN9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_098630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485844.1">
        <property type="nucleotide sequence ID" value="XM_002485799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMN9"/>
    <dbReference type="STRING" id="441959.B8MMN9"/>
    <dbReference type="GeneID" id="8099691"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_098630"/>
    <dbReference type="eggNOG" id="ENOG502SCIP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010004_1_0_1"/>
    <dbReference type="InParanoid" id="B8MMN9"/>
    <dbReference type="OrthoDB" id="4464205at2759"/>
    <dbReference type="PhylomeDB" id="B8MMN9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="402"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="552"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="593"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED13606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="607" mass="67329" checksum="7DCE1BFA84D6F5DF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNH6</accession>
    <name>B8MNH6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IFRD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_102920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IFRD family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486303.1">
        <property type="nucleotide sequence ID" value="XM_002486258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNH6"/>
    <dbReference type="STRING" id="441959.B8MNH6"/>
    <dbReference type="GeneID" id="8102911"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_102920"/>
    <dbReference type="eggNOG" id="KOG2842">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039188_0_0_1"/>
    <dbReference type="InParanoid" id="B8MNH6"/>
    <dbReference type="OMA" id="HISGRHI"/>
    <dbReference type="OrthoDB" id="18978at2759"/>
    <dbReference type="PhylomeDB" id="B8MNH6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039777">
        <property type="entry name" value="IFRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007701">
        <property type="entry name" value="Interferon-rel_develop_reg_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354">
        <property type="entry name" value="INTERFERON-RELATED DEVELOPMENTAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354:SF1">
        <property type="entry name" value="INTERFERON-RELATED DEVELOPMENTAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05004">
        <property type="entry name" value="IFRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Interferon-related developmental regulator N-terminal" evidence="3">
        <location>
            <begin position="70"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED14065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="485" mass="54485" checksum="CA017D6307368956" modified="2009-03-03" version="1">MHDLRRQALLESRKTVSRKAASREASRSNSRVVSAQTSRQNSRQSSRAASRYPSDEEDEGNLSDETGTWSTSSLDDLAENPESDNADWPEELADCIQDILDRKRSSVQGREEALSSFCRLSKFHYVEEEIRNHIQDLLAAFSRSIKYESSVRESVLALKALEFLAVTAYDDTIYDAVESLLTRTIRDSTSGLIKVAAINCLGTCAYFGGTSEEAKMDQMEMLLDIVASDGQSIDASDDAAVVTVALQQWGFLATDIEDLEGESEEVVEIMIEQLASADSNVQIAAGENIALLYEKSYTPQEEEDESDEDEDNEDEEDEEDIPGSSGPKLIKRYTPYHDTYQLERILASLATVSGKRISKKDKKSLHTNFASILTTVENPRLGPMYSKAINQNTNRQYGSKRQVKVGSEGVMNIDRWWKWLRLASLRRVLQGGFMEHYFQGNRAVLDALPVMLRDARRTNADRGGHKKAARMRNSTKRMILEEDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MP52</accession>
    <name>B8MP52_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoric ester hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_105030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486529.1">
        <property type="nucleotide sequence ID" value="XM_002486484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MP52"/>
    <dbReference type="GeneID" id="8098724"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_105030"/>
    <dbReference type="eggNOG" id="KOG3947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041441_3_0_1"/>
    <dbReference type="InParanoid" id="B8MP52"/>
    <dbReference type="OMA" id="PHHDAWS"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="PhylomeDB" id="B8MP52"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF18">
        <property type="entry name" value="ESTER HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="47"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED14291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="402" mass="45470" checksum="76B62E4FBDABF05A" modified="2009-03-03" version="1">MANPFIERPLVDRLLASPLAFFLHPMHILLLRLRGAPHSPSSTTRPIRVVCISDTHTLEWHDIPDGDLLIHAGDLSNDGSVREIQATVNWLKTLPHRHKIVIAGNHDSYFDPRSRLDEDRDTVSSSLANISASTASIRSVDIDIDDFDGGRIDWSYHSQTSEYDYPSSFDSKPQNTTHEEADEKEDIHYLQHTSITLTFPAQTPTQRSRTLTIYGAPQIPTPMPMGPEHAFTYPPAQDAWTNTIPIETDILVTHTPPYTHRDLGPNFSIGCPFLLSEVWRVRPILHVFGHVHFAHGSEPVFWDEAQRAWERISGRCSARQRRLQQQSAGSLWAGRLGGLYDLVTPRNWIDAFKVLFYGVTGIIWSRVWGGQVNRGAGWMVNAAMMYKDTGILRNKPQCVEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQ08</accession>
    <name>B8MQ08_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">A-pheromone receptor PreA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_054100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487009.1">
        <property type="nucleotide sequence ID" value="XM_002486964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQ08"/>
    <dbReference type="FunCoup" id="B8MQ08">
        <property type="interactions" value="80"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MQ08"/>
    <dbReference type="GeneID" id="8100349"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_054100"/>
    <dbReference type="eggNOG" id="ENOG502S44N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027592_3_2_1"/>
    <dbReference type="InParanoid" id="B8MQ08"/>
    <dbReference type="OMA" id="RWIQVTC"/>
    <dbReference type="OrthoDB" id="2874149at2759"/>
    <dbReference type="PhylomeDB" id="B8MQ08"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004932">
        <property type="term" value="F:mating-type factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14966">
        <property type="entry name" value="7tmD_STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097:SF1">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00899">
        <property type="entry name" value="GPCRSTE3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED12898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="354" mass="39567" checksum="6FDD88FACE36D31A" modified="2009-03-03" version="1">MDSYHRSTQAILAPVLSFLGLTLCIPPMVWHASNRNWGASFLVAYVMFEDLINISNALIWPTDDIDSWWDGAVFCDIQVKLNVATQVGMPGALLCVFRSLALAMDVNNSALVPSRGQRLRNKAVNVVFCIVLPVLQMVAHYTIQDIRYNIFAIGGCTAGFDESWPTLVFLLCPSVIYVAAAVYCFLIIIRLVKYTSEFSAILGASRSNLTTQRFIRLFGLSLIMILIILPLQIYILFAQIEIMLPLHPYSWEGTHGTDLSRIEKIPSNDNLRFERWIPPACSFLIFSFFGLGRDAANMYNIFFNVIGLKGFSVSFSSFKSTSDSSTSSAENNKGGSWYRSLRSKKNSWLGSGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQD6</accession>
    <name>B8MQD6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_058270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487449.1">
        <property type="nucleotide sequence ID" value="XM_002487404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQD6"/>
    <dbReference type="STRING" id="441959.B8MQD6"/>
    <dbReference type="GeneID" id="8106429"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_058270"/>
    <dbReference type="eggNOG" id="ENOG502S791">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106738_1_0_1"/>
    <dbReference type="InParanoid" id="B8MQD6"/>
    <dbReference type="OMA" id="LWKIKHW"/>
    <dbReference type="OrthoDB" id="2148716at2759"/>
    <dbReference type="PhylomeDB" id="B8MQD6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="27"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="143" mass="15503" checksum="1261C032B8B370D0" modified="2009-03-03" version="1">MSMSLPAALTPVLSGREAIIDALYRCVSAFADDAVFDLNGTIMDGIDAINAQCFASISKMDTTHYLTNIRINILDGSKAEVTCTALAQHYHGGEGMKAGAIPLLAGSFYWVDLVRDAGDGLWKVKKWKLKTSWGQGDWGVFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQT0</accession>
    <name>B8MQT0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_052500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486838.1">
        <property type="nucleotide sequence ID" value="XM_002486793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQT0"/>
    <dbReference type="STRING" id="441959.B8MQT0"/>
    <dbReference type="GeneID" id="8098199"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_052500"/>
    <dbReference type="HOGENOM" id="CLU_1653312_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQT0"/>
    <dbReference type="OrthoDB" id="4325529at2759"/>
    <dbReference type="PhylomeDB" id="B8MQT0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED12727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="160" mass="18095" checksum="735D2CDC80BC74D1" modified="2009-03-03" version="1">MDSDAPIGGNIPQEQNRQLQAQAKVNKRAQELAFAFQQTRPRATTRLYSKPQAKWGVWCKEQGFSDGELVTENKMVTFLDEWVLHRPIRSSCYKRACTDENGDLVTQTLGVSSLKQYAAGLVDLWKFQKTLGQSYSTAGPDGKIQMSKAKDHRLRNPTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQY3</accession>
    <name>B8MQY3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_053360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486929.1">
        <property type="nucleotide sequence ID" value="XM_002486884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQY3"/>
    <dbReference type="STRING" id="441959.B8MQY3"/>
    <dbReference type="GeneID" id="8098287"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_053360"/>
    <dbReference type="eggNOG" id="ENOG502SIQI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074647_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQY3"/>
    <dbReference type="OrthoDB" id="4225980at2759"/>
    <dbReference type="PhylomeDB" id="B8MQY3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="272" mass="30037" checksum="241857E0220FF5FE" modified="2009-03-03" version="1">MPPRTRKSAAASSSKLAGKPNASVAAADKQPIDVSSPVSEDGASSDGDDRLVIDEDEEDMEVFDMTDRDSTEINAPNKDGQRSLYAVGGGGYNALKTFRGQVYSGMAIGGSHKWNYDQGVWKETKVEPDRWEIDYNATKRRARKAPKGSGVPVGTEYHWFIIAHQYVVKQDDNTYETHLVGSKYKLAHKSISATAWSVPTVKAQRERETDILEDAKRRVQGLPPVLAAEKAKVGARQEKGQQTLDTLFGKRKGTEDSFASRQTKKRKMGSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8MR11</accession>
    <name>B8MR11_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 20">Postreplication repair E3 ubiquitin-protein ligase RAD18</fullName>
            <ecNumber evidence="5 20">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">RING-type E3 ubiquitin transferase RAD18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">TSTA_053620</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 20">E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 20">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17 20">Interacts with E2 UBC2, forming a complex with ubiquitin ligase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20">Belongs to the RAD18 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 20"/>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486957.1">
        <property type="nucleotide sequence ID" value="XM_002486912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MR11"/>
    <dbReference type="FunCoup" id="B8MR11">
        <property type="interactions" value="293"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MR11"/>
    <dbReference type="GeneID" id="8098313"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_053620"/>
    <dbReference type="eggNOG" id="KOG0287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028491_2_0_1"/>
    <dbReference type="InParanoid" id="B8MR11"/>
    <dbReference type="OMA" id="AKSEYEP"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="PhylomeDB" id="B8MR11"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097505">
        <property type="term" value="C:Rad6-Rad18 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000172">
        <property type="entry name" value="E3 ubiquitin-protein ligase RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039577">
        <property type="entry name" value="Rad18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004580">
        <property type="entry name" value="Rad18_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00599">
        <property type="entry name" value="rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51908">
        <property type="entry name" value="ZF_UBZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19 20" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14 19 20" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 20" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 18 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="22">
        <location>
            <begin position="30"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="UBZ4-type" evidence="24">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="23">
        <location>
            <begin position="242"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="106"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="350"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00054102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00066140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU368093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EED12846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="414" mass="46930" checksum="D6C0C019E46AB904" modified="2009-03-03" version="1">MDRPFDIPDSTDWLTSSLPGVAPLESALRCQICKDFFNNPVITSCSHTFCSLCIRRCLSSEGKCPACRATDQLLKLRRNWAVQEILESFQNARPNILALARQAQTTTLSTDKTKEEEDTEMSHPATKKRRLNQSDDAQPEMRRTRSQGRQLERQPMLVGPESIDDSKDEDYMPDDGLVPCPMCNRRMKEAAVFNHLDNCKGSIEENALNPHTSYLRQPQHSFRSSQNKSPAKPLERLPTMNYSLIKDNMLRKKLKELGIPDWGPRAILQRRHTEWMNLWNANCDAKVPKTKDELRRDLDVWERTQGGAAPQPGSSSGPNAVMAKTFDAAAWSANHDDDFKRLIENARKKKDMRKIQTQDKEEENDNSTSQQDDNAALNNANGENHTLPTGEQPMGNGVIAEPSPQPYTPLNDTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRG3</accession>
    <name>B8MRG3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_056000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487211.1">
        <property type="nucleotide sequence ID" value="XM_002487166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRG3"/>
    <dbReference type="GeneID" id="8100665"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_056000"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="InParanoid" id="B8MRG3"/>
    <dbReference type="OMA" id="MLMITAA"/>
    <dbReference type="OrthoDB" id="4213692at2759"/>
    <dbReference type="PhylomeDB" id="B8MRG3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF81">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="67"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED13100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="516" mass="57398" checksum="1B8E5535B2607D61" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRT9</accession>
    <name>B8MRT9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_057630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487384.1">
        <property type="nucleotide sequence ID" value="XM_002487339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRT9"/>
    <dbReference type="GeneID" id="8108899"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_057630"/>
    <dbReference type="HOGENOM" id="CLU_2224958_0_0_1"/>
    <dbReference type="InParanoid" id="B8MRT9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED13273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="106" mass="12292" checksum="9F697BAE04BA1EB7" modified="2009-03-03" version="1">MSTSTNMRVFRLRSAWRLSQTSRLSAPRYQNQFRSVATKQASPAYPQTSSTLNQAIPNPSPSTSLAVKKLVTPIHRTEDLWHPRSRHKGGRRVKLIRGRNRLWRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRU5</accession>
    <name>B8MRU5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_057680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487390.1">
        <property type="nucleotide sequence ID" value="XM_002487345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRU5"/>
    <dbReference type="STRING" id="441959.B8MRU5"/>
    <dbReference type="GeneID" id="8108904"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_057680"/>
    <dbReference type="HOGENOM" id="CLU_1603311_0_0_1"/>
    <dbReference type="InParanoid" id="B8MRU5"/>
    <dbReference type="OMA" id="NVRVHNS"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="186" mass="18745" checksum="B7554540740E3E1C" modified="2009-03-03" version="1">MFRWTPGLWFSSNVRVHNSSPSIAQPLTLLFQVLKMRFTLPTIAFLTIVTGALAGSGEGNNHQQYSKHVSSMAHSTTLSHETVTTPIPTHSSKAVTPSKTSAVPSKSSFAVNPSKSAGGGSNSGHGGSGSGSGSDSGSESGSGGEEGGSETAPTYVPGNPAARIDAQEATFLGAALGALGAFVALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRZ2</accession>
    <name>B8MRZ2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_059160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487539.1">
        <property type="nucleotide sequence ID" value="XM_002487494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRZ2"/>
    <dbReference type="STRING" id="441959.B8MRZ2"/>
    <dbReference type="GeneID" id="8107386"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_059160"/>
    <dbReference type="HOGENOM" id="CLU_1416045_0_0_1"/>
    <dbReference type="InParanoid" id="B8MRZ2"/>
    <dbReference type="PhylomeDB" id="B8MRZ2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="192" mass="20982" checksum="788E69625E6D83A9" modified="2009-03-03" version="1">MPRSCLNKALAKLQPRIWRLRRRREVVRQRAPRLWRARNLLPPRNEVVLQKGASIAAASKTSSPTKRGKPSKAATASSIKAPTKAKAKGRPSKSKAVVVASTAESGSRSAKSSPQKTSSSTKKAAIPKKAAGAFPSRIGDIIELSSPEIEELRPDLAKDMRLGFLEIPHPRRFGENLMLVSTRAISAVKNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8MS67</accession>
    <name>B8MS67_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_001930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487779.1">
        <property type="nucleotide sequence ID" value="XM_002487734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MS67"/>
    <dbReference type="STRING" id="441959.B8MS67"/>
    <dbReference type="GeneID" id="8098784"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_001930"/>
    <dbReference type="eggNOG" id="ENOG502QVJ3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_953687_0_0_1"/>
    <dbReference type="InParanoid" id="B8MS67"/>
    <dbReference type="OrthoDB" id="4367135at2759"/>
    <dbReference type="PhylomeDB" id="B8MS67"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED12125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="34292" checksum="4D4D8CE842223489" modified="2009-03-03" version="1">MHWSLRDPKHPKKAALSTEFIFSAAVEEYIVSVSTKRHMLERQAHSHNHYSAAGSTLASLHYEEIESKETQIKSYLDSYMTTNQILSTLYNDNRESIIKLRDIYNKKRKLRDKFLDGKTPVQALISVVPDNRFSFILDEKEESYKFILECLAKVYAQVDLLLPNYILTDKDMALMNTITTHIEKNILTRVRPILTNEVLHTIYSGNPAAVKKDITKYKTHIKSQWKDFFRSFNKIVYAKTKEEKDEAVNSFKVEYSSETWQEVMDYIDSEWLNNSITQRFLHCYLLNIKHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSD3</accession>
    <name>B8MSD3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_003770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487974.1">
        <property type="nucleotide sequence ID" value="XM_002487929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSD3"/>
    <dbReference type="FunCoup" id="B8MSD3">
        <property type="interactions" value="91"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MSD3"/>
    <dbReference type="GeneID" id="8100089"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_003770"/>
    <dbReference type="eggNOG" id="ENOG502S0R6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070319_2_0_1"/>
    <dbReference type="InParanoid" id="B8MSD3"/>
    <dbReference type="OMA" id="GEKTGFW"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="PhylomeDB" id="B8MSD3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03141">
        <property type="entry name" value="GATase1_Hsp31_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="6">
        <location>
            <begin position="28"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED12320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="236" mass="25590" checksum="B2B85BAB193331D7" modified="2009-03-03" version="1">MAPKVLIVLTSQNVIPNTDHQTGWYLPEFAHPWKILHDAGVELTVASPKGGEAPLDPASVEMFKQDEIAVNFHKNQEPLWKNTVRLADIVPRAKEFDAIFYVGGHGPMFDLVSDPISLSLIQTFASAKKPVSAVCHGPIVFVNATTPSGEPLLRDATVTGFSNVEEDQAQLTKLMPFLLEDRLKAIPGTKYVKADQPWGEKVVVDKTYQLGGVLITGQNPASATGVGKELLKALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSH1</accession>
    <name>B8MSH1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-binding oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_000730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED11999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487653.1">
        <property type="nucleotide sequence ID" value="XM_002487608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSH1"/>
    <dbReference type="STRING" id="441959.B8MSH1"/>
    <dbReference type="GeneID" id="8108696"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_000730"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_1_0_1"/>
    <dbReference type="InParanoid" id="B8MSH1"/>
    <dbReference type="OMA" id="DWHATSF"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="PhylomeDB" id="B8MSH1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF53">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877973" evidence="5">
        <location>
            <begin position="31"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="72"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED11999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="500" mass="54346" checksum="01BBFB27084D92A0" modified="2009-03-03" version="1">MANSRGSIQARLAWLLQFFCLIFISTTAQAVSLDLHVLSACQQFKSLYGNLTFLANQTQYTALADENWSQTAWADPSCILQPANTPQVQNILRLLTAQQIPFAIRSGGHLPSPLGANINRGVLIDLSLLKTLDYDAANEVVSIGSGLRWQAVYEGLAPYERTAVGGRLLDVGVGGLLLGSGLSYLSDLYGLACDNVVNFEVVLASGEMVNANATSNSDLFWALKGGANNFGIVTTFTVRTYPIGNVWGGIKAYDLEYLPDVLAALNTYQSVENKDPYANLMVQAATTNSSIGVLLNLVYLKPMANPAAFDPFYGIPTLEDTTVIQSFVDFMSEAVMPDIPRWDWHATSFKPTASLYSQIADIVTTAPEINELISVNTATLVVGIQPISTSLIAAGHAAGSNALGLEAVNQTWLVLDIGWEKSTDDTKAHNLTRSLKNRIEKASVDAGQYVEYIFMNDASWDQEVIAHYGDESVDRLKAVRDKYDSTEIFQRLVKGGFKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSY8</accession>
    <name>B8MSY8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_002110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487798.1">
        <property type="nucleotide sequence ID" value="XM_002487753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSY8"/>
    <dbReference type="STRING" id="441959.B8MSY8"/>
    <dbReference type="GeneID" id="8102821"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_002110"/>
    <dbReference type="eggNOG" id="ENOG502QSMW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026434_0_0_1"/>
    <dbReference type="InParanoid" id="B8MSY8"/>
    <dbReference type="OMA" id="FRWDELF"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="PhylomeDB" id="B8MSY8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050723">
        <property type="entry name" value="CFA/CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667">
        <property type="entry name" value="CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667:SF2">
        <property type="entry name" value="FATTY ACID C-METHYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED12144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="440" mass="50259" checksum="85D63C8EC750AD0F" modified="2009-03-03" version="1">MAIVHRPTWLQSYAKYWVVRTLTKIQRGRATFICRYEDDATVVVGEKDTAVPDELNATIYVVDPNFWVRFCTALDLGLSEAFMLQEIECPDLNKIFNIYFKNKDYLGFGNPILQAGQRLSRLLWSPSNDVQQARLNASAHYDTSNELFAAFLSPDMNYSCAHWTADPAETLQTAQERKVDTLLKKLRLTSNHHMLEIGCGWGDVMVKAAQRYSCRVTGITLSSEQKELVEQKIKNAKLDHLVSVLLCDYRTTPVPDSGYDRVISIGMFEHVGRKYLNEYFSTISRLLNPTTGLLVLDGITFTNKMHESRSPVDTFIGRYIFPGGYLPSIHLLTEALHKGSKGTLEITYAKNIGPHYGKTLLAWRDNFLRNWDRIMADYMRKHPSASKEDIEAFRRMWLYYFLSCEAGFRSRALGNYVICAARTPEPAVPYTSAGFQEMLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTD0</accession>
    <name>B8MTD0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar import and degradation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_004330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
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            <end position="173"/>
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        <location>
            <begin position="234"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar import/degradation Vid27 C-terminal" evidence="2">
        <location>
            <begin position="414"/>
            <end position="765"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <location>
            <begin position="370"/>
            <end position="411"/>
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            <begin position="167"/>
            <end position="178"/>
        </location>
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        <location>
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            <begin position="370"/>
            <end position="389"/>
        </location>
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF08553"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF17747"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17748"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED12384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="789" mass="88744" checksum="B930327A167A933D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </location>
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        </location>
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        </source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="352" mass="37660" checksum="6579F04324DB977C" modified="2009-03-03" version="1">MSGARHWEQDKEATVYIGNLDERVTDSLVWELMLQAGRIVNVHLPKDRVTQTHQGYGFVEFISEEDAEYAARIMNQVRLYGKPIRVNKASADKQKTVEVGAELFVGNLDPMVTEQVLYDTFSRFGTLLSMPKIARDDANLSKGYGFVSFADFDASDAAIANMHGQYLMNKEVSVQYAYKKDGKGERHGDQAERMLAAQARKHNVQPQTQPLPPQLMGQAPTPGMMPGNPVAADGARHIAPGGPPDFAAGRGPIPMQASQQPPRPGPPAQPLSAPHPGLPARPPPSQAGFGGPPPPGFVPPGFNNAPQQPGFPPQPPAGFAPPAGFGGSMPGAQGTPPPFPPGFQPPGYARAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="66" xmlns="https://uniprot.org/uniprot">
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    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED12501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="369" mass="40683" checksum="1BBF51A7083D14EE" modified="2009-03-03" version="1">MEIFGSPPTNINALSPSSAARDPRVQLPTTTDPPGPNNPPKQLVWLIFGATGHMGRSLVKAALLHNDLVAAVGRTFEDSHESMQRMQTENESCLGLLCDVRVRETVSEVIDHAIAHFSRIDIIANCSGYGVIGACEDQDDYDIRNQFETNFMGTLNIIQLSLPYFRDRKAGRYVIFSSTSGALGVPGLGPYCASKYAVEGLVESMLYEIDSFNIKVALIEPGHVRRDDVNTKLTPRTWDDPPAQLPAYGHFFIKPTSEPYRTHSSPAAHARRLLLWLGDKQPVSAVKAAELVWQLGHCSFPPLRLLLGSYAVDSIRDRLRCITEEIEDWKYLSFPLPGEAVGGPNTEQKKSPAYKSDENEDGPATATSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUP2</accession>
    <name>B8MUP2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_108910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488466.1">
        <property type="nucleotide sequence ID" value="XM_002488421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUP2"/>
    <dbReference type="GeneID" id="8103147"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_108910"/>
    <dbReference type="HOGENOM" id="CLU_2514173_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUP2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="85" mass="9733" checksum="024A0623689CC68B" modified="2009-03-03" version="1">MLSTQEWMQLYKISAIPGSRTVEQSQQTYKIDGDGHHGFLCLEENGRSYSTWMGAGTTLGDNLFPDDERERELQGIFLYPNETIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUS7</accession>
    <name>B8MUS7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_109950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488571.1">
        <property type="nucleotide sequence ID" value="XM_002488526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUS7"/>
    <dbReference type="STRING" id="441959.B8MUS7"/>
    <dbReference type="GeneID" id="8107227"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109950"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122987_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUS7"/>
    <dbReference type="OMA" id="THIEHAT"/>
    <dbReference type="OrthoDB" id="4226558at2759"/>
    <dbReference type="PhylomeDB" id="B8MUS7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="21103" checksum="20813DFE896B9D3D" modified="2009-03-03" version="1">MDDFTAWVTGPTARSNREGIEVIITDALDWERRSRATFEANKTAIIHFTPKAHKSEQEPFTIKGQAVKPKDHVKILSVIIDTRLKYKEHIARAASKGLEAAMELRRLRGLSPSTARQLFTSTVTTAVDYASNVWMHAFKDKAIGPINRIQKVGQINADREPILGGASSNGTHIEHATNIKAVQNHAPDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUU1</accession>
    <name>B8MUU1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_110410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488617.1">
        <property type="nucleotide sequence ID" value="XM_002488572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUU1"/>
    <dbReference type="STRING" id="441959.B8MUU1"/>
    <dbReference type="GeneID" id="8107273"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_110410"/>
    <dbReference type="eggNOG" id="ENOG502RJUK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_654129_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUU1"/>
    <dbReference type="OrthoDB" id="4330117at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR RGLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED11861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="420" mass="47262" checksum="C27595D2880167F4" modified="2009-03-03" version="1">MPRWRPTPDSKQKTGESKRGRTSRAGELPLAKSGEYRLVAVSSLTHAHNVIPTGVHDIQKCLSSPGSLPYCNFMYHLFYPSELRLILSKPRFTINGSDRSLDAKVWINKITQANDLVQAQLFSESVIGPDVKLSTLPGSFNLFDSEEESTQKLVPSDLPIRGAHRVASETKAFFSFREMAGIMHPVDEIGKQRYRAACDACRYSKVRCSGGWVCIRCKKHDYKCRYGVAHRPGRPKGSKNKTTLEKLENLQAAQQRMYVPKAESGVGFSKPEKTINNSIVRSTPGNFGHSAHIKMGNYVFANPEFSVYTSPTFAGIGYYNTPENDYENISPAIAQNLPWPIRSADTTGWMQLLGWTRVQSKTNVWALTMFPSDRGPNHRPFVIVQNSLSYHGSGDRIEDPTLRNIMLYKLYNMISEDLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUZ5</accession>
    <name>B8MUZ5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_110640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488641.1">
        <property type="nucleotide sequence ID" value="XM_002488596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUZ5"/>
    <dbReference type="STRING" id="441959.B8MUZ5"/>
    <dbReference type="GeneID" id="8107296"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_110640"/>
    <dbReference type="HOGENOM" id="CLU_000288_34_22_1"/>
    <dbReference type="InParanoid" id="B8MUZ5"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="PhylomeDB" id="B8MUZ5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="38444" checksum="CA5D81DF49F277CD" modified="2009-03-03" version="1">MLDEKFELSFYVPGDDNCYTYGRIGVLNVVLSPLSETNIAKTTIVATVATSMRRTFARLKLILLLGAAGAIPNDVHDMRLGDAVIAVPSDGSSGIVQYSFPETEVIRELASPPQSILDCVRQFQFELQDDPEKITKWMEEGLNKFPHMKRTFGPPSNRVDRLFHADYLHISQGCYRCDSSRLVQRGSRADTNPRLFYGAIATADTEIFNAKERDKIGRQTNCLCVDTGSAGLQLIEVPTIVIRCIINYADSHSKEQRKWRDYAAMTGAACAKGFILDLSTVSWDMDPSEHSVDSAERLWTSTTAKTTIAATQFTTSQGTPTNTAGRTTPTGSTWSLVDMNPSVASTGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8MV44</accession>
    <name>B8MV44_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_109390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488516.1">
        <property type="nucleotide sequence ID" value="XM_002488471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MV44"/>
    <dbReference type="GeneID" id="8107171"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109390"/>
    <dbReference type="eggNOG" id="ENOG502T53F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1099125_0_0_1"/>
    <dbReference type="InParanoid" id="B8MV44"/>
    <dbReference type="OMA" id="ARFWWER"/>
    <dbReference type="OrthoDB" id="5384804at2759"/>
    <dbReference type="PhylomeDB" id="B8MV44"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="253" mass="29912" checksum="EE86F0B608553C9B" modified="2009-03-03" version="1">MSHYLDSRMLQFGKFCEALESSSALFENIRHSWSDSSNCTLKESPETLEGWAEAIRDDRNLTFSHRHSLLLNWMFLLSRLQPYLTPFDILANFLEDKLSDETLRFFSSLLTVSGHYKEPPNMSDIEDSISRGLKEDYYVASKLWEVYRRHDYGWRHSVRGRVFDEDFSPKKVADEIKNFENHSRNWWEFLREAEDDQSRDFQIAIPQYYSKEVFDMTDDGEAGKLFFTLHGKDLETIRKMCPSTKRSIIISNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8MVA8</accession>
    <name>B8MVA8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_008600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962662">
        <property type="protein sequence ID" value="EED11564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488745.1">
        <property type="nucleotide sequence ID" value="XM_002488700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MVA8"/>
    <dbReference type="GeneID" id="8103248"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_008600"/>
    <dbReference type="HOGENOM" id="CLU_013929_8_3_1"/>
    <dbReference type="InParanoid" id="B8MVA8"/>
    <dbReference type="OMA" id="PVNREWA"/>
    <dbReference type="OrthoDB" id="3691787at2759"/>
    <dbReference type="PhylomeDB" id="B8MVA8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="18032" checksum="74A15D75A11ACF48" modified="2009-03-03" version="1">MRTVCTYAPHSLPWSMIPPRHSLVREMVNYLLSQHGNQQVYNLVKRRPEIESKFSRKYNYEGAKCEDPKMIQEYFDRVREVTLEYGILPEDIYNFDETGFAMGLCATAKVVTGSDRYARPKLLQPVNREWATAIEQLIRLDGPCFHSNTPTKSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8MVH0</accession>
    <name>B8MVH0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_007740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962663">
        <property type="protein sequence ID" value="EED11484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488800.1">
        <property type="nucleotide sequence ID" value="XM_002488755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MVH0"/>
    <dbReference type="STRING" id="441959.B8MVH0"/>
    <dbReference type="GeneID" id="8103448"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_007740"/>
    <dbReference type="HOGENOM" id="CLU_116561_0_0_1"/>
    <dbReference type="InParanoid" id="B8MVH0"/>
    <dbReference type="OrthoDB" id="2663223at2759"/>
    <dbReference type="PhylomeDB" id="B8MVH0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="1">
        <location>
            <begin position="30"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="124" mass="14284" checksum="9EF9F6E6B0800060" modified="2009-03-03" version="1">MAQQQCTISKREKDLAALSINEYPLKHSALLDLGSSIHVFNEIERFMNFRKATAGDFLWAGTHQVPVLGYGEVDIEIHSLGGRLQILRLYNMAYCKDFVANLVSFQQLRKHGIWWDIRRGFNCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MVH6</accession>
    <name>B8MVH6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_007870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962663">
        <property type="protein sequence ID" value="EED11497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488813.1">
        <property type="nucleotide sequence ID" value="XM_002488768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MVH6"/>
    <dbReference type="STRING" id="441959.B8MVH6"/>
    <dbReference type="GeneID" id="8103461"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_007870"/>
    <dbReference type="eggNOG" id="ENOG502SVBM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_3_2_1"/>
    <dbReference type="InParanoid" id="B8MVH6"/>
    <dbReference type="OrthoDB" id="4159828at2759"/>
    <dbReference type="PhylomeDB" id="B8MVH6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="109"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="289" mass="31537" checksum="666326C3BB13632B" modified="2009-03-03" version="1">MSKWYKSTGTFQSPPLKDPLRLNSFPAVTIHEKRDILVCNLLQNSAEAGDIPLDSPAVPTTSLYFLDITMAQVEESVLQVGNTAPGSDEIPTCILKVAWPLIKDKVLIPITLLSVLGKGLECLVVQNMAWISIYYKVLARQQFRALPLRSANDLTTCLTHDVEQALNQGMTALLLTLDVKGAFDAVLPGRLIHRLYEQGWPTNLILWIASFATGRSVQIRLNGEIGPSTDIACGLPQGSPVSGILFMLYIAPLFRLGNPRNRFGYVDDAANLAISTSLATNCKALSDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTI8</accession>
    <name>B8LTI8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Arp2/3 complex subunit (Arp3), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_065240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340453.1">
        <property type="nucleotide sequence ID" value="XM_002340412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTI8"/>
    <dbReference type="FunCoup" id="B8LTI8">
        <property type="interactions" value="747"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LTI8"/>
    <dbReference type="GeneID" id="8108495"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_065240"/>
    <dbReference type="eggNOG" id="KOG0678">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027965_3_0_1"/>
    <dbReference type="InParanoid" id="B8LTI8"/>
    <dbReference type="OMA" id="GIHYPIR"/>
    <dbReference type="OrthoDB" id="421448at2759"/>
    <dbReference type="PhylomeDB" id="B8LTI8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:actin cortical patch organization"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="Actin, Chain A, domain 4"/>
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        <property type="entry name" value="Actin"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
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        <source>
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            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED23066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="438" mass="47560" checksum="A9122A2124F576B2" modified="2009-03-03" version="1">MTSQTPAVVMDNGTGYSKIGFAGNDSPSFVFPTAIATKAAGGGATAASGRPAVANKPSFLGGGGGGGGHLSGKRGTEDLDFFIGDEALAAANGPGYGIHYPIRHGQIENWDHMERFWSNSIFKYLRVEPEDHYFLLTEPPLNPPENRENTAEIMFESFNCAGLYIAVQAVLALAASWTSSKVTDRSLTGTVIDSGDGVTHVIPVAEGYVIGSSIKSIPIAGRDITYFVQSLLRDRGEPDSSLKTAEKVKEEYCYVCPDIVKEFARYDREPDRFLKHTVTSPNGRSIQIDVGYERFLAPEIFFNPEIYSSDFLTPLPTVVDGVIQSSPIDVRRGLYKNIVLSGGSTLYKDFGRRLQRDIRHLVDARIRASEARSGGAKSGGLEVQVVTHKRQRHGPWFGGSLLGQTPEFRSYCHTKAEYDEIGPSIVRRFALLGGPGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTX7</accession>
    <name>B8LTX7_TALSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_072010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED23807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002341153.1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_072010"/>
    <dbReference type="eggNOG" id="ENOG502RNWG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_490171_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="57"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="368"/>
        </location>
    </feature>
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        <location>
            <begin position="500"/>
            <end position="556"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
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        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="556" mass="62556" checksum="3096874DD0659A38" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8LU52</accession>
    <name>B8LU52_TALSN</name>
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        <recommendedName>
            <fullName evidence="4">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">TSTA_060210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002339870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LU52"/>
    <dbReference type="STRING" id="441959.B8LU52"/>
    <dbReference type="GeneID" id="8106159"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_060210"/>
    <dbReference type="eggNOG" id="ENOG502SJ0M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_638060_0_0_1"/>
    <dbReference type="InParanoid" id="B8LU52"/>
    <dbReference type="OrthoDB" id="2156052at2759"/>
    <dbReference type="PhylomeDB" id="B8LU52"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06293">
        <property type="entry name" value="Kdo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="49821" checksum="4F0231951D94B524" modified="2009-03-03" version="1">MSPTRAEEKRDCPPDDSDSEDISRNLDSTARIRALTFSSSPPQRQHRSGRQFKRTDDSTQESLDFCTQRCLLSLKTGDWLDENCPNVDRHRNANSKHHQIHVSDFLRLLKWQLDNDLDHYCTPCGESGIRGFPFKISLMPFGYTILGKGTTDRRWPIVRQEENVYQVLRSVQGSAVPVFLGTIDIEWIYFHEGFRITHFLILSWGGDQFNPLCCEEERWNEYQRTKEDIRRLGVRHGDLHESNILWNTELGRVQFIDFHKAELSWTKKRKRDATNSSRPRRKFLHLRERNLELPSRHNEREHSIVLRGHHFLRLPAAGRAPFKVTLTEYGYTFVANGVQKANERDLAHEINMYSYISPLQERNIPVYLGRIAVTRPYSLVIISNDGLCGNDIKLEDSCCQCVLLKASGRVIPTNKGSSTGFSTWKVLSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUI2</accession>
    <name>B8LUI2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_071520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341142.1">
        <property type="nucleotide sequence ID" value="XM_002341101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUI2"/>
    <dbReference type="STRING" id="441959.B8LUI2"/>
    <dbReference type="GeneID" id="8110252"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_071520"/>
    <dbReference type="HOGENOM" id="CLU_538815_0_0_1"/>
    <dbReference type="InParanoid" id="B8LUI2"/>
    <dbReference type="OrthoDB" id="4526484at2759"/>
    <dbReference type="PhylomeDB" id="B8LUI2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="373"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="523"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="560"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED23755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="591" mass="64441" checksum="3454CC3031EB66CD" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUL3</accession>
    <name>B8LUL3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin filament organization protein App1-like, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_072610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341257.1">
        <property type="nucleotide sequence ID" value="XM_002341216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUL3"/>
    <dbReference type="STRING" id="441959.B8LUL3"/>
    <dbReference type="GeneID" id="8102323"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_072610"/>
    <dbReference type="eggNOG" id="ENOG502RYXR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030283_0_0_1"/>
    <dbReference type="InParanoid" id="B8LUL3"/>
    <dbReference type="OMA" id="RDSSWKT"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="PhylomeDB" id="B8LUL3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF1">
        <property type="entry name" value="FILAMENT ORGANIZATION PROTEIN APP1-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="1">
        <location>
            <begin position="246"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="452" mass="51888" checksum="A9C7A6F7215205CE" modified="2009-03-03" version="1">MSSHGSTACLNVILRNTAASGCKQSGWNRILDIVPSILGYLDIIIQDMADIKTYTEEVVRRRSHSVEKKTSRKHLHRILRIIGFHTETTTVHPIKPGQHVVWLFDNVAYQPVHRSNQDQTWEAEMVACVFSRERRNMGQYVARVADFVGLDGKFGEDPIIRRRIIQRLRSLLYVVAPSRTLPVDMPLPNGTVRRFHLGPTNQNGVLTQTVSLPQMGIVDRSVVTSELVGSRGQVRMQTRFAAPEGWLLISDIDDSIKVTLTPETVGILRTTFVTDPEPIIGMPELYQLIERELNPTWIYLSASPYNLYKFLRNFLHLFYPPGTLLLRQATWKNLGEFIKSYNTGTGTYKMRQMDKIHSWLPARKVICVGDSTQSDPEIYAEMYRRHAGWIKAIFIRKVTNIPHMEKKNSSSRFQRAFEGVPHDVWRIFERPSGLYESIAKLNYEPSARQVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVC8</accession>
    <name>B8LVC8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_073370</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341334.1">
        <property type="nucleotide sequence ID" value="XM_002341293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVC8"/>
    <dbReference type="STRING" id="441959.B8LVC8"/>
    <dbReference type="GeneID" id="8100243"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_073370"/>
    <dbReference type="eggNOG" id="KOG0922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_5_11_1"/>
    <dbReference type="InParanoid" id="B8LVC8"/>
    <dbReference type="OMA" id="FHEVMET"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="PhylomeDB" id="B8LVC8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000020">
        <property type="entry name" value="ATP dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001075">
        <property type="entry name" value="ATP dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF136">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX35-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="32"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="234"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED23947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="670" mass="74790" checksum="093A5C4EC87ECE70" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVH1</accession>
    <name>B8LVH1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_073760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341377.1">
        <property type="nucleotide sequence ID" value="XM_002341336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVH1"/>
    <dbReference type="STRING" id="441959.B8LVH1"/>
    <dbReference type="GeneID" id="8106671"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_073760"/>
    <dbReference type="eggNOG" id="ENOG502QVCU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022730_0_1_1"/>
    <dbReference type="InParanoid" id="B8LVH1"/>
    <dbReference type="OMA" id="WNRNLML"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="PhylomeDB" id="B8LVH1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF279">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="37"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="459" mass="50245" checksum="49D1021F6990DC42" modified="2009-03-03" version="1">MASKPFPVANGLTSFWRTEPSSLDNHRSTQDLPDHSDIVVIGAGYAGASTTYHILDQCDSSPKPSIVILEARQACSGATGRNGGHMKPDLYSSIGTLAARFGVEAAAEVAAFEAKHVSAIKSLIDQEEISCDLEISKAIDAQLDESHNAKLLAGYNELIAGGSEATKGAEYVSGREAETFSGVKGAKGAFTYQTGRLWPYKLITELLRRAIAKGVNLQTHTPVLNVSKVRDADGHWTVETPRGSIKTKYVVFATNAYTSSIAPEYHGKIIPSRGICSRIVVPSPPKQPLQASYLIRFNSWQYDYLIPRPDGSIIVGGARPTFFHDLESWYGNTDDSKMIEAASHYFDNYMQRHFHGWESTGAYTDRVWTGIMGYTTDSLPHVGQVPQKQGQFILAGFNGHGMPQVFLSAKGIANMIVRGVEFEDTGVPRLFKTTQERLDSKENRILDAPYAAGKPRPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWJ0</accession>
    <name>B8LWJ0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved lysine-rich protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_076670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341688.1">
        <property type="nucleotide sequence ID" value="XM_002341647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWJ0"/>
    <dbReference type="STRING" id="441959.B8LWJ0"/>
    <dbReference type="GeneID" id="8105647"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_076670"/>
    <dbReference type="eggNOG" id="ENOG502S2JB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014855_0_0_1"/>
    <dbReference type="InParanoid" id="B8LWJ0"/>
    <dbReference type="OMA" id="WAAHTGK"/>
    <dbReference type="OrthoDB" id="5593352at2759"/>
    <dbReference type="PhylomeDB" id="B8LWJ0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039712">
        <property type="entry name" value="Meu6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039483">
        <property type="entry name" value="Meu6_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42073">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42073:SF1">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15406">
        <property type="entry name" value="PH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="65"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED24301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="536" mass="55898" checksum="2A6462814176D916" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWU1</accession>
    <name>B8LWU1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_079300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341961.1">
        <property type="nucleotide sequence ID" value="XM_002341920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWU1"/>
    <dbReference type="STRING" id="441959.B8LWU1"/>
    <dbReference type="GeneID" id="8107605"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_079300"/>
    <dbReference type="eggNOG" id="ENOG502SVBM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051551_0_0_1"/>
    <dbReference type="InParanoid" id="B8LWU1"/>
    <dbReference type="OrthoDB" id="4526357at2759"/>
    <dbReference type="PhylomeDB" id="B8LWU1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED24574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="340" mass="36580" checksum="0A176A0C008E292B" modified="2009-03-03" version="1">MARKGPGTDGPLQTALLESTSAAITRASEGQKIFSPIAVFLDKHRSQTTGLAPHLLRALTALSDDLASVAQQHFNAYISGISMTSILPALSPSPSSSPTLNPLPPSPPPSRPPSGLNQSTYATITQYAPVKSTPTTHPKASIKKPMPLVKQPLPDIWLFVRLPADHAARKMEAYAIYSSLRSQLNLNSAALKEVQATKTGFALCPSSPEALLALEAQKETISTFFVNYQIECSFRWVSYRVTNVPRKIGQILDGQYSLIPINPTLLSLEISETTGLKPISISETTTSAANPNTLSSSWFLFNAHDAGNSIMHDPVHAPLDADYTAPQSILKRAMSITAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWU5</accession>
    <name>B8LWU5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Peptidyl-prolyl isomerase CWC27</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Peptidyl-prolyl isomerase cwc27</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 18">Rotamase CWC27</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TSTA_079330</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cyclophilin-type PPIase family. CWC27 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341965.1">
        <property type="nucleotide sequence ID" value="XM_002341924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWU5"/>
    <dbReference type="FunCoup" id="B8LWU5">
        <property type="interactions" value="1098"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LWU5"/>
    <dbReference type="GeneID" id="8107617"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_079330"/>
    <dbReference type="eggNOG" id="KOG0885">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_14_5_1"/>
    <dbReference type="InParanoid" id="B8LWU5"/>
    <dbReference type="OMA" id="CKNFLQH"/>
    <dbReference type="OrthoDB" id="442970at2759"/>
    <dbReference type="PhylomeDB" id="B8LWU5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000034">
        <property type="entry name" value="Peptidyl-prolyl isomerase CWC27 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF6">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
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        <source>
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    <sequence length="554" mass="61490" checksum="9DA9152469D2A6B4" modified="2009-03-03" version="1"> </sequence>
</entry>
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    <accession>B8LXU5</accession>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
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            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
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    <sequence length="177" mass="20246" checksum="9D47141F37D1DF81" modified="2009-03-03" version="1">MRYSSHLMNSIMASAEYNASFSGAHNYGLQAGYIAGNVHYYPTGKLPSLHHERPETPPAPSLSIPFLRDPDFIDRATILNQLHDRCATPGSKTALVGLGGVRKSQLVIEYAYRIHEQEPDTWVFWIYASNVDRFEQSYQKIADHVKLFGRRDPKANIFKLVHDWLRDLKKQKVDTDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Bud3_C"/>
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    </dbReference>
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        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF21">
        <property type="entry name" value="GUANYL NUCLEOTIDE EXCHANGE FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH_BUD3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="459"/>
        </location>
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            <end position="1525"/>
        </location>
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            <end position="1330"/>
        </location>
    </feature>
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        <location>
            <begin position="1354"/>
            <end position="1368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED23264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1551" mass="172217" checksum="A16F72D4C2D3801C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZ29</accession>
    <name>B8LZ29_TALSN</name>
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        <submittedName>
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        </submittedName>
    </protein>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
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            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002477991.1"/>
    </dbReference>
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    <dbReference type="STRING" id="441959.B8LZ29"/>
    <dbReference type="GeneID" id="8105184"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_083060"/>
    <dbReference type="HOGENOM" id="CLU_759051_0_0_1"/>
    <dbReference type="InParanoid" id="B8LZ29"/>
    <dbReference type="OMA" id="AHHELEN"/>
    <dbReference type="OrthoDB" id="3599542at2759"/>
    <dbReference type="PhylomeDB" id="B8LZ29"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="380" mass="43361" checksum="1F06F2C2DCBCB689" modified="2009-03-03" version="1">MAPAASTEPGEFDPEGKDARQLNNYVSQRMNSYEDVYDDLLYAAYKQHFEKWTIDDFKKSDMIQLGKLINLLRCNGVFVNTTRAHLVAENLMNVLAETDPHVWTEEEVIAHVKRGKELRSENLNDQFAAIITMHQRPPKTSEEKAQQRIPRTPLMPETPSPFPTFGPKTRARSAANSGLGTPTTVPVTSHPNTGQADSNQHMEEQAHKDSLADLISTPQALLNLGKMYTDELKYGAEKNDSFTWKLQIFYDLCQRAFIPPTQEAYHPAFPTMLKGQALQYYYATRQTWLLHGHDPITGLGDHFEGEEYHRAIQQEWNNVIFQSVIDKNLYKTLSECLEIMVSTLQQLYHGLDRDLQTPAYHRIKLVEATHTHPAFQSATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZ88</accession>
    <name>B8LZ88_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Inner centromere protein ARK-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_083640</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INCENP family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478095.1">
        <property type="nucleotide sequence ID" value="XM_002478050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZ88"/>
    <dbReference type="STRING" id="441959.B8LZ88"/>
    <dbReference type="GeneID" id="8103327"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_083640"/>
    <dbReference type="eggNOG" id="ENOG502S0AD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003318_1_0_1"/>
    <dbReference type="InParanoid" id="B8LZ88"/>
    <dbReference type="OMA" id="PVPKWAQ"/>
    <dbReference type="OrthoDB" id="6123at2759"/>
    <dbReference type="PhylomeDB" id="B8LZ88"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005635">
        <property type="entry name" value="Inner_centromere_prot_ARK-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142:SF1">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03941">
        <property type="entry name" value="INCENP_ARK-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner centromere protein ARK-binding" evidence="9">
        <location>
            <begin position="1139"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="125"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="456"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="631"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1089"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="489"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="540"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="631"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="646"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="714"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="767"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="813"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="833"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="865"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="891"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="958"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="991"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1017"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1141"/>
            <end position="1150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED21132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1242" mass="135906" checksum="5D510D53CAA8ACF2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZ95</accession>
    <name>B8LZ95_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_088840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478611.1">
        <property type="nucleotide sequence ID" value="XM_002478566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZ95"/>
    <dbReference type="STRING" id="441959.B8LZ95"/>
    <dbReference type="GeneID" id="8106981"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_088840"/>
    <dbReference type="HOGENOM" id="CLU_063715_0_0_1"/>
    <dbReference type="InParanoid" id="B8LZ95"/>
    <dbReference type="OrthoDB" id="5410741at2759"/>
    <dbReference type="PhylomeDB" id="B8LZ95"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="2">
        <location>
            <begin position="147"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED21648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="343" mass="39404" checksum="F3EAB12A9D5DDA44" modified="2009-03-03" version="1">MLKGVQPILTQGPTGVSLPSRPSNPDIAMPTAFTYLQKVGNPMPQQHPQSERTNKPHPTRTDPDNAQTTSKSRVSKKSDKRGRPKKISDDLTQKMIMLLENSNGDVSWEQLGHSVGVDGKWLSKQARETRMQYALAHHKWQNEWRSMLFSDFVNFGLGTTRKAKVFNRKDERLCEDCLQSREEIDKALFHCWAMVGYDYKGPLIFLETEDNDLSAMSQRDYISQIIQLHVQPIVTARRMIYLDNASEVYEHATAPQNMVHAYLDSLHLPYIQNPPTSPDLNVLKDVLLLLKKRLQKRSIGDQIQLKIAVLEEWDKITTKEINKLVDTMKLRMEKVLTRKGMPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8M089</accession>
    <name>B8M089_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_084170</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478149.1">
        <property type="nucleotide sequence ID" value="XM_002478104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M089"/>
    <dbReference type="FunCoup" id="B8M089">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M089"/>
    <dbReference type="GeneID" id="8101510"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_084170"/>
    <dbReference type="eggNOG" id="KOG2867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030733_2_0_1"/>
    <dbReference type="InParanoid" id="B8M089"/>
    <dbReference type="OMA" id="IHESQDV"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="PhylomeDB" id="B8M089"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="371"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="371"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="404"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED21186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="452" mass="50399" checksum="C9AC36CB474C140D" modified="2009-03-03" version="1">MPYQVLERIDKAHHVFVVPSKKIHDGNDVQTFFTTKAYRDIMAFLLQLNRAIFPRKIDNTVQTWQLNSLEVEYSEPTRRIQLLLSRLESIIDEVPPDTGPRRFGNISFRKWHQIVEERLAGFLDEALGTEVLENSQDSSAQNVTSRQELQAYLLGSFGSAQRLDYGTGHELSFLAFLACLWKLSVFPETGPGVEERGIVIGIIEPYLDLVRNLIKTYTLEPAGTHGVWGLDDHFFLPYIFGSAQYSPAIAETDETPVEGSLSDAPAPTSVVKNNIVERERRKNMYFSAIGFIYDVKKGPFWEHSPMLFDISGVTGGWGKINKGMIKMYNAEVLSKFPVVQHFPFGSLFSWDRDPSAISSLPSIYSQQANTSTISPSVTSQPASTRAPWSQPSTSLPGATAVPWATNTARNPQVSTNDTPSATRTPFQNTLPATSRNPPDLMAPTRAPWAKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8M098</accession>
    <name>B8M098_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-mannosidase A</fullName>
            <ecNumber evidence="6">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Mannanase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TSTA_084260</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="6"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478158.1">
        <property type="nucleotide sequence ID" value="XM_002478113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M098"/>
    <dbReference type="STRING" id="441959.B8M098"/>
    <dbReference type="GeneID" id="8101519"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_084260"/>
    <dbReference type="eggNOG" id="KOG2230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005015_3_0_1"/>
    <dbReference type="InParanoid" id="B8M098"/>
    <dbReference type="OMA" id="PWKPAYI"/>
    <dbReference type="OrthoDB" id="2866996at2759"/>
    <dbReference type="PhylomeDB" id="B8M098"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001511">
        <property type="entry name" value="Beta-mannosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000084">
        <property type="entry name" value="Beta-mannosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041625">
        <property type="entry name" value="Beta-mannosidase_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF5">
        <property type="entry name" value="BETA-MANNOSIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17753">
        <property type="entry name" value="Ig_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 21" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="10 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877344" description="Beta-mannosidase A" evidence="16">
        <location>
            <begin position="18"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="20">
        <location>
            <begin position="28"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="17">
        <location>
            <begin position="241"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="19">
        <location>
            <begin position="738"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase Ig-fold" evidence="18">
        <location>
            <begin position="842"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF17753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EED21195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="926" mass="103361" checksum="F6C5EE4308A34A12" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0K7</accession>
    <name>B8M0K7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_085350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478267.1">
        <property type="nucleotide sequence ID" value="XM_002478222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0K7"/>
    <dbReference type="FunCoup" id="B8M0K7">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M0K7"/>
    <dbReference type="GeneID" id="8106141"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_085350"/>
    <dbReference type="eggNOG" id="KOG0634">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_6_1"/>
    <dbReference type="InParanoid" id="B8M0K7"/>
    <dbReference type="OMA" id="DFLQWPV"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="PhylomeDB" id="B8M0K7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000080">
        <property type="entry name" value="Aminotransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858:SF1">
        <property type="entry name" value="LD15494P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="1">
        <location>
            <begin position="61"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="466" mass="51794" checksum="68102B2DE137D3DC" modified="2009-03-03" version="1">MSQAPSGANSCTSNDTHINQAQTKYPIDLFRGWPNPALLPVDALAKSAATVLSSPSIYESGLQYGPDEGYGPLREHIASWLGSFYRDELESEKRRRNPITAERLCVTGGASQNLACVLQVFTDSAYTRNIWMVAPTYYLACRIFHDAGFMGRLRGVPEDEEGIDLDVLERGLQEAEDKAASEGNTKPVYTLPRPWSKIYKHVIYLTPTFANPSMKVASLRRREGLVQLARRFDALIISDDVYDFLQWPSDPNATDIKDTACVPRLVDVDGYLDGGPIDEWGNAMSNGSFSKLIGPGMRVGWAEGTEKFAYGLSQAGSSRSGGAPSQLSSTFVDQLLPSGILQRHIKQELIPAYRARYNRIISAINDHLLPLGFKLPAGNQPISGGYFIWLDLPLSLTGDLLAQRALADEMLMIGSGTMFQVQDDCSENHQRFERSIRLCFAYERFEVLYEGVERLGNVARRMLTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1R0</accession>
    <name>B8M1R0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_093930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479110.1">
        <property type="nucleotide sequence ID" value="XM_002479065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1R0"/>
    <dbReference type="GeneID" id="8103721"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_093930"/>
    <dbReference type="HOGENOM" id="CLU_1504430_0_0_1"/>
    <dbReference type="InParanoid" id="B8M1R0"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="179" mass="20372" checksum="4ED2B02A80F23AA6" modified="2009-03-03" version="1">MNTSLSDHMFLPGKRFFRSVKVPNLRRPPRSVFGKATGSAQLMVKRDCDLFTRDESFLDGMGLVDHYYHREDYILFINELSNPDWRNTLESKVLYGLSGIVQRTQRNRVSFRMYDCHPYEKNARIHILAEEIPVVVGICIWGYATKGRTLQVEGSPEKLDLSSSQATGEGNGISATKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1S5</accession>
    <name>B8M1S5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphatidylserine decarboxylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_094080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479125.1">
        <property type="nucleotide sequence ID" value="XM_002479080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1S5"/>
    <dbReference type="STRING" id="441959.B8M1S5"/>
    <dbReference type="GeneID" id="8103736"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_094080"/>
    <dbReference type="eggNOG" id="KOG2419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033450_1_0_1"/>
    <dbReference type="InParanoid" id="B8M1S5"/>
    <dbReference type="OMA" id="NACESFP"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="PhylomeDB" id="B8M1S5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022237">
        <property type="entry name" value="PsiD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF9">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G01730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12588">
        <property type="entry name" value="PSDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L-tryptophan decarboxylase PsiD-like" evidence="4">
        <location>
            <begin position="48"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED22162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="441" mass="49211" checksum="0A15849BF9772475" modified="2009-03-03" version="1">MSCPCSASSVPNIPRPGAWLPSNPHRLWDWINKKVESLEPKPTQRLLQSVKDFKIHVQNDPTLYMLFTEMLDEVPAKYVKDPSGKRPEVRDLDTLFTFFDEILRQPPSWDPSPQIGTPVNAVLDWPMGTKAGFAAFLRDDVNAHFKSMLQSWGDFLSTEYSCSTLTTDTGGWFSVEALESDHMKDFAKTFRCDPKLKHWGFKSWDAFFTRDFNEIDSIRAVAEAGNTGVIVSAAESTPFAVQTGVQAHDKFWIKGQPYSLKHMLDHDSRAGLLTGGTVYQAFLSADSYHKWHTPVSGTILDYRMIDGTYYSEPLSTGFSPDLGDPDPDPGADSASQGYISSVAARAVIWIQADGPAGLICLVFIGMAEVSSIEVTMPVGKHFEKGEELGKFHFGGSSFCMILRPELDVQFSLPDDWKDRPKNMKQVKVRSKLATVKFVIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1V9</accession>
    <name>B8M1V9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TGF beta receptor associated protein 1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_085680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478300.1">
        <property type="nucleotide sequence ID" value="XM_002478255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1V9"/>
    <dbReference type="STRING" id="441959.B8M1V9"/>
    <dbReference type="GeneID" id="8104533"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_085680"/>
    <dbReference type="eggNOG" id="KOG2063">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008225_0_0_1"/>
    <dbReference type="InParanoid" id="B8M1V9"/>
    <dbReference type="OMA" id="DNWKGNF"/>
    <dbReference type="OrthoDB" id="5325112at2759"/>
    <dbReference type="PhylomeDB" id="B8M1V9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF27">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="40"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="231"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1191"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1208"/>
            <end position="1221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED21337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1221" mass="136503" checksum="D8D7530F86B77360" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8M229</accession>
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        </recommendedName>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EED21493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002478411.1"/>
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    <dbReference type="GeneID" id="8100858"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_087290"/>
    <dbReference type="eggNOG" id="KOG4593">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010064_1_0_1"/>
    <dbReference type="InParanoid" id="B8M229"/>
    <dbReference type="OMA" id="YKLDFMP"/>
    <dbReference type="OrthoDB" id="331602at2759"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED21493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="713" mass="81180" checksum="756BAAD92259C170" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2B2</accession>
    <name>B8M2B2_TALSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_088120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002478494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2B2"/>
    <dbReference type="STRING" id="441959.B8M2B2"/>
    <dbReference type="GeneID" id="8106909"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_088120"/>
    <dbReference type="eggNOG" id="ENOG502T5KU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="B8M2B2"/>
    <dbReference type="OMA" id="KECELAF"/>
    <dbReference type="OrthoDB" id="4392204at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877497" evidence="1">
        <location>
            <begin position="21"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="225" mass="24892" checksum="925EC57F4E31289F" modified="2009-03-03" version="1">MAYLQYLLLLLTSRVPSVWAQVLFHGTSVIISPFNGSDHPRDSSFHTANFYCYATPTGYFSFGWWLPAKPGTDTSRCSPDAGLDSIDWFEYTTSGGCGATTCKVHAVNYMLNNTRSPLIDVDYFAVSLDIANGEPHGQLALSYFDQPGGAYAVGSREILSGGISDHRQAKECELAFKTLSKIYAEYEAPLTFDLKDPCKKGLLHGLTASFSDHMKQSFLGWRKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2T2</accession>
    <name>B8M2T2_TALSN</name>
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        <submittedName>
            <fullName evidence="16">EBP domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSTA_094330</name>
    </gene>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479150.1">
        <property type="nucleotide sequence ID" value="XM_002479105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2T2"/>
    <dbReference type="STRING" id="441959.B8M2T2"/>
    <dbReference type="GeneID" id="8103761"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_094330"/>
    <dbReference type="eggNOG" id="KOG4826">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072128_0_0_1"/>
    <dbReference type="InParanoid" id="B8M2T2"/>
    <dbReference type="OMA" id="VIEGWFC"/>
    <dbReference type="OrthoDB" id="58557at2759"/>
    <dbReference type="PhylomeDB" id="B8M2T2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000247">
        <property type="term" value="F:C-8 sterol isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047750">
        <property type="term" value="F:cholestenol delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004769">
        <property type="term" value="F:steroid Delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007905">
        <property type="entry name" value="EBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207:SF0">
        <property type="entry name" value="3-BETA-HYDROXYSTEROID-DELTA(8),DELTA(7)-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207">
        <property type="entry name" value="STEROL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="7" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="15">
        <location>
            <begin position="55"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EED22187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="225" mass="25919" checksum="FFAACF71C15FC420" modified="2009-03-03" version="1">MTSHPYFPLGLEIQDYRSNESGLFYIVGLFSTGLAVSLCVILGLAIMKRTSMTSADKLTILWFALSGILHCFFEGYFVTHHDRMGPAQDIFGQLWKEYAKSDSRYLVSDSFVVSIETITVVLWGPLCLLVAYLTTIKHSLNHPLRIIICMAHLYGDTLYYATSLFDYYVNGISHSRPEVLYYWVYYFLMNFVWIVVPAYILYNSVCLVSQALNQFESETRSKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3E5</accession>
    <name>B8M3E5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1275 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_095660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479280.1">
        <property type="nucleotide sequence ID" value="XM_002479235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3E5"/>
    <dbReference type="STRING" id="441959.B8M3E5"/>
    <dbReference type="GeneID" id="8105877"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_095660"/>
    <dbReference type="eggNOG" id="ENOG502S0ZW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061825_0_1_1"/>
    <dbReference type="InParanoid" id="B8M3E5"/>
    <dbReference type="OMA" id="RAPIEWM"/>
    <dbReference type="OrthoDB" id="5223589at2759"/>
    <dbReference type="PhylomeDB" id="B8M3E5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF6">
        <property type="entry name" value="DUF1275 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G07550)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="285" mass="31191" checksum="CF62DB8CA2765C95" modified="2009-03-03" version="1">MLERSISFAPTDQISTDETLNQKPGTLAKIKYRGVVHYLSSDINTKRADIILIICAFVSGLVDGVSFTAWGSFASMQTGNSVFIALGVSGQPRYPAYLWAKSLISVATFIISNIFFSRFIRFLGAKRRITNIICFLIQTLALLIASLLVEIDIISPRAEDPRAPIEWMQVLPISLLAFQAAGQIVASRTLEYDEIPTVVLTTLLCDLLIDPNLLARRNAKRNRRVACFVTLILGAMTAGGLFKLTNMSSGLWLGFALKAVITISWVAWEGAQNVKGDGDVVEGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3G4</accession>
    <name>B8M3G4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translationally-controlled tumor protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_095850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCTP family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479299.1">
        <property type="nucleotide sequence ID" value="XM_002479254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3G4"/>
    <dbReference type="FunCoup" id="B8M3G4">
        <property type="interactions" value="899"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M3G4"/>
    <dbReference type="GeneID" id="8105896"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_095850"/>
    <dbReference type="eggNOG" id="KOG1727">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095877_0_1_1"/>
    <dbReference type="InParanoid" id="B8M3G4"/>
    <dbReference type="OMA" id="CAMITEG"/>
    <dbReference type="OrthoDB" id="10248936at2759"/>
    <dbReference type="PhylomeDB" id="B8M3G4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018103">
        <property type="entry name" value="Translation_control_tumour_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01002">
        <property type="entry name" value="TCTP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCTP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED22336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="178" mass="19910" checksum="BC1F13A6395A9660" modified="2009-03-03" version="1">MIIYKDIITGDEIISDTFKIVEDGPVLWTADCRKYMKGSENFELEGANPSAEGGDEEEGGEGGQVMVHDIEDQFRLVWLKTEEGMKPSKDAFKAHLKSYVKAVNNKLKEKGASEETIKEFQSGAAAAVKKILANYDNYDVLMNQSMDPNGMHVLIDFREDGVTPFATVWKHGLEEMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8M465</accession>
    <name>B8M465_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_040020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481242.1">
        <property type="nucleotide sequence ID" value="XM_002481197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M465"/>
    <dbReference type="STRING" id="441959.B8M465"/>
    <dbReference type="GeneID" id="8109761"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_040020"/>
    <dbReference type="eggNOG" id="ENOG502SC56">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_725993_0_0_1"/>
    <dbReference type="InParanoid" id="B8M465"/>
    <dbReference type="OrthoDB" id="4226558at2759"/>
    <dbReference type="PhylomeDB" id="B8M465"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="43105" checksum="D4D4CB000D83B3F0" modified="2009-03-03" version="1">MLGRRTDAYWYPQEPWPGRWESRFAYVQEPWRELPHVVIDEREKAVSVHDNITRKKEHIAIYTDGSGYQGYIGVSMVIPAYGKQRTQCIGTEGTSTVYAGEACGIKFALETVLQIAEQDVRIKKPVIFSDSQAALRTLINPRMVSGQMYIRDCVDLLRKCMVEDIDDAWEKLWDKQKAGKPTKKLVTRPSKRTLQYWMFLRKATSSILIQLCTERIGLAHYLWRINKREHPYCAGGLSGQSVKHIFMECPLYADERALMWTRIKGFRRTTDLQKLLSEKTAAVAIAQFIIDTQVLDQFRVADPEAIGMYESAGTAAQPGLANDKDTDVGTRTNAREDDVRSRSASLSVMTNIDTNTSLGSRDSEPANGDVSRGHKGRICEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4V6</accession>
    <name>B8M4V6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication licensing factor MCM2</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">DNA replication licensing factor mcm2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Minichromosome maintenance protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TSTA_026930</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479825.1">
        <property type="nucleotide sequence ID" value="XM_002479780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4V6"/>
    <dbReference type="FunCoup" id="B8M4V6">
        <property type="interactions" value="952"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M4V6"/>
    <dbReference type="GeneID" id="8098973"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_026930"/>
    <dbReference type="eggNOG" id="KOG0477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_0_0_1"/>
    <dbReference type="InParanoid" id="B8M4V6"/>
    <dbReference type="OMA" id="TYERVTT"/>
    <dbReference type="OrthoDB" id="844at2759"/>
    <dbReference type="PhylomeDB" id="B8M4V6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006267">
        <property type="term" value="P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17753">
        <property type="entry name" value="MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008045">
        <property type="entry name" value="MCM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF44">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12619">
        <property type="entry name" value="MCM2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01658">
        <property type="entry name" value="MCMPROTEIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="20">
        <location>
            <begin position="487"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="733"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="742"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00078186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EED19391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="900" mass="101813" checksum="E7F3F03D820316E2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5F6</accession>
    <name>B8M5F6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_030290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480196.1">
        <property type="nucleotide sequence ID" value="XM_002480151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5F6"/>
    <dbReference type="GeneID" id="8101708"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_030290"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <sequence length="508" mass="56533" checksum="77E3F79AFD602D3B" modified="2009-03-03" version="1">MSTHETAADVENEALDKKNVRVVSTTNESVGIGLKDSFPETARVIDHEAERALCRKFDFRLLPILAFMYLCNALDKGNLGNAKTDGMDKDLGMTGSQYNLLLSIFFVPFVVFAPPIAMLAKRFSPAKVISVMMFSFGSFTLLSASVSSYSGLFALRWFLGMSEAAFFPLVIYYQTTFYRRGELARRLAIFYAASNIANAFSGLLAFGVFQIKDPALQGWKYLFLIEGAFTVCFSAFAFFYLPASPQQARFLNEEEKQLAFYRIQVDSSAVVNEEFNLRRALRILQRPTSYAFLAIEICLGVPLQGVALFLPQIVARLGYSTVKTNLYTVAPNVTGAVMLLVLAFSSDATRLRSPFIVLGFIFTLVGFVIYAAINDVVAQIHLAYYACFMMTWGTSAPSVLLSTWYNNNIADEGQRVLLTSIGVPLANLMGLVSSNVFRSQDAPKYMPALVTVASFGGAGALITACLGVYMWFDNVRRNRRAGRKIDARDVPTERLWDGPKTEEFRWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5K1</accession>
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        <submittedName>
            <fullName evidence="11">Multidrug resistance protein, putative</fullName>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED19895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="768" mass="86100" checksum="EFD61C0F735848AF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6A9</accession>
    <name>B8M6A9_TALSN</name>
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        <recommendedName>
            <fullName evidence="4">Pyridine nucleotide-disulphide oxidoreductase family protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">TSTA_025990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="441959.B8M6A9"/>
    <dbReference type="GeneID" id="8108011"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_025990"/>
    <dbReference type="eggNOG" id="ENOG502S49J">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007263_2_0_1"/>
    <dbReference type="InParanoid" id="B8M6A9"/>
    <dbReference type="OMA" id="DVPYIPR"/>
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    <dbReference type="PhylomeDB" id="B8M6A9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014839">
        <property type="entry name" value="Crt10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08728">
        <property type="entry name" value="CRT10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="691"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="803" mass="90247" checksum="20A6D699E9145F08" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6U4</accession>
    <name>B8M6U4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SNARE complex subunit (Vam7), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_034030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential for proper morphogenesis of the vacuole. May exist as structural reinforcement on the surface of the vacuolar membrane and be required for maintenance against rupture by osmotic pressure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480598.1">
        <property type="nucleotide sequence ID" value="XM_002480553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6U4"/>
    <dbReference type="FunCoup" id="B8M6U4">
        <property type="interactions" value="128"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M6U4"/>
    <dbReference type="GeneID" id="8097820"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_034030"/>
    <dbReference type="eggNOG" id="ENOG502RXJQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033748_2_0_1"/>
    <dbReference type="InParanoid" id="B8M6U4"/>
    <dbReference type="OMA" id="QASVRSW"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="PhylomeDB" id="B8M6U4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097576">
        <property type="term" value="P:vacuole fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06897">
        <property type="entry name" value="PX_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15858">
        <property type="entry name" value="SNARE_VAM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000058">
        <property type="entry name" value="VAM7p Vacuolar SNARE protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="PX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="7">
        <location>
            <begin position="295"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED20164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="358" mass="40116" checksum="82930F07AB91DB3C" modified="2009-03-03" version="1">MPSNVEITIPTATLTGDYTTYNITVRLPLRSIVVQKRYSEFATFHDDLVHQVDAQPPVPLPKKSWFYNTNSNEKLREERRRGLEKYLQAINNSDDQRWRNTSVWRSFLNLPIQASAGENTSSARLHKAVTSPGSAGSAPITDPVLWLDCHREMKSHLHDARLYLTRRDQATTPQKQHESSAHAKSSLAKAGSMITALEDGLKNPGNENWAGSGLGEGEIRRRKDLLASAKKEKDGLENLHHAMLQKSRLDTAVASIQDKNELMSSSKPRGGGRVLGKETDKTRELDNQGVLRLQKQTIESQDKSVGELLKIVSRQKELGIAINNELEIQNQLLSMADEDVDRLQNKIDIGSKRVDKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8M751</accession>
    <name>B8M751_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase activator (Mob2), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_035010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480705.1">
        <property type="nucleotide sequence ID" value="XM_002480660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M751"/>
    <dbReference type="STRING" id="441959.B8M751"/>
    <dbReference type="GeneID" id="8104342"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_035010"/>
    <dbReference type="eggNOG" id="KOG0440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038321_0_0_1"/>
    <dbReference type="InParanoid" id="B8M751"/>
    <dbReference type="OrthoDB" id="10261121at2759"/>
    <dbReference type="PhylomeDB" id="B8M751"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED20271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="413" mass="45538" checksum="CC8E438F1F165FC5" modified="2009-03-03" version="1">MALFLIRASGGWEWILLHAETNNRGRSDGQSEQQLLSSPLLRVPLLSAAIVGAPIIDLIFLLRLSSCLSIHYSRWQPSFRACFGRGGNNKNSNNQPKMNTGGQGQQVAQPQQAVPGAQGLNNSPSIASNMSADIVSNNEDAPKYFFQEKYAPLNVKGNFLTLCACPKNVELGEWLAHQIVEQYRLLHGMLQVIQEVNTVNGYPICNESTCPTMSAGRLTYTWLVDGRAAKISAPKFINRVEKWIVSKIHDPVMFPTDPVQGAPHTFASGDVSTPPATTPIAAGPTNLNASLTTLAGQDWIGKSSGFPPTFYKDCQGIMKQMFRCYAHLYHGHWLDPFWHINRHEMLNMCFVHFVTVAKYYKLVADKEMEPMQPLIDLYMKQEKIPPEAIAGHWASQEAAAAGSSTPAANVPST</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-11-30" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7D2</accession>
    <name>MTNA_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="1">M1Pi</shortName>
            <shortName evidence="1">MTR-1-P isomerase</shortName>
            <ecNumber evidence="1">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">mri1</name>
        <name type="ORF">TSTA_035790</name>
    </gene>
    <organism>
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-(methylsulfanyl)-alpha-D-ribose 1-phosphate = 5-(methylsulfanyl)-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="1"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480786.1">
        <property type="nucleotide sequence ID" value="XM_002480741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7D2"/>
    <dbReference type="SMR" id="B8M7D2"/>
    <dbReference type="FunCoup" id="B8M7D2">
        <property type="interactions" value="712"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M7D2"/>
    <dbReference type="GeneID" id="8107528"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_035790"/>
    <dbReference type="eggNOG" id="KOG1468">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_1_3_1"/>
    <dbReference type="InParanoid" id="B8M7D2"/>
    <dbReference type="OMA" id="CETRPLN"/>
    <dbReference type="OrthoDB" id="2461at2759"/>
    <dbReference type="PhylomeDB" id="B8M7D2"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.420:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="entry name" value="translation initiation factor eif-2b, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004326">
        <property type="entry name" value="PRK05720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF1">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0486">Methionine biosynthesis</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000402055" description="Methylthioribose-1-phosphate isomerase">
        <location>
            <begin position="1"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03119"/>
        </source>
    </evidence>
    <sequence length="384" mass="41472" checksum="A141B2EDD3053DB7" modified="2009-03-03" version="1">MSLQAIKYFDNQLQIIDQLQLPFVTEYIPIRSAQDGWYAIKEMRVRGAPAIAIVAILSLAVELNEIHTAGKLSSSSEEVGLFIIEKLHYLVTSRPTAVNLADAARKFENMVTEHTRAQDSTGQSLVAAYLKEAELMLVHDLSDNQNIGEYGAKWILERAATQGQNKVNVLTHCNTGSLATAGYGTALGVIRSLHAKNALNRVYCTETRPYNQGARLTAYELVHEKMPATLITDSMAASLLAKSHSKVSAIVVGADRVAANGDTANKIGTYALAVLAKYHGVKFLVAAPRTTIDRGTLTGTEIVIEERAPSEVTTIKGPLQGRVGDTLQMETIQLAATGIDVWNPAFDVTPAALIDAVITEKGVVEKGSDGFFHFDALFEESASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7P7</accession>
    <name>B8M7P7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_028820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480034.1">
        <property type="nucleotide sequence ID" value="XM_002479989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7P7"/>
    <dbReference type="GeneID" id="8099001"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_028820"/>
    <dbReference type="HOGENOM" id="CLU_1267269_0_0_1"/>
    <dbReference type="InParanoid" id="B8M7P7"/>
    <dbReference type="OrthoDB" id="4217201at2759"/>
    <dbReference type="PhylomeDB" id="B8M7P7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="219" mass="24223" checksum="04556E1EAF6326D1" modified="2009-03-03" version="1">MDEPPATYSPEGRSVHPSKRRRLEVNHSEGPPPGCLLFNTTEPADTVLQYKIVSAYIAAFPPAGGLLINQWTIVCRVNRTETYQISLKALPGVGDDCAYNDIYLELAKGPTINATGRLHGMAKTFKISIVVDSTIGDLVEVLFDNNLNKYQLLHGRGNRAWMCGVLQVAIEIFHNIDENVAAMSYVAQGWEAEFPIRPGDFQTPMMGIWLDRTAWSGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8M2</accession>
    <name>B8M8M2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Catalase</fullName>
            <ecNumber evidence="13">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSTA_037550</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 14">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Alkaloid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="13"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480969.1">
        <property type="nucleotide sequence ID" value="XM_002480924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8M2"/>
    <dbReference type="FunCoup" id="B8M8M2">
        <property type="interactions" value="972"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M8M2"/>
    <dbReference type="GeneID" id="8102131"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_037550"/>
    <dbReference type="eggNOG" id="KOG0047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010645_2_0_1"/>
    <dbReference type="InParanoid" id="B8M8M2"/>
    <dbReference type="OMA" id="KFRWNVF"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="PhylomeDB" id="B8M8M2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08157">
        <property type="entry name" value="catalase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF9">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0017">Alkaloid metabolism</keyword>
    <keyword evidence="5 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 13 16" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="15">
        <location>
            <begin position="18"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EED20535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="499" mass="57023" checksum="7A287881A6D73EE1" modified="2009-03-03" version="1">MGKDEPGTYRYNETPTYTTSNGCPVFDPESAQRIGKNGPLLLQDFHLIDLLAHFDRERIPERVVHAKGAGAYGEFEVTDDISDITTIDMLRGIGKKTKLVTRFSTVGGEKGSADSARDPRGFSVKFYTEQGNWDWVFNNTPVFFLRDPSKFPIFIHTQKRNPQTNLKDATMFWDYLSTHQESAHQVMHLFSDRGTPYSYRHMNGYSGHTFKWIKSDGTFNYVQIHCKTDQGNKTLTNEEAGELSNTNPDWHTQDLFQAIERGEYPSWTCYVQVLSPEQAEKFRWNIFDLTKVWPQSEVPLRRFGRFTLNKNPQNYFAEIEQAAFAPSHLVPGVEPSADPVLQARLFSYPDTHRHRLGVNYQQIPVNCPLHAFNPYQRDGAMAVNGNYGANPAYPSSFRPLKFEPVKASQEHEKWVGAVTSQQIPVTDEDFVQANALWHVLGRTPGQQENFVKNVSGHLCNANERVRKQTYGFFSRINATLGEKIKKATEKNVTKEHARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8M920</accession>
    <name>B8M920_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_111510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481307.1">
        <property type="nucleotide sequence ID" value="XM_002481262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M920"/>
    <dbReference type="STRING" id="441959.B8M920"/>
    <dbReference type="GeneID" id="8098806"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_111510"/>
    <dbReference type="eggNOG" id="ENOG502SVBM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_23_3_1"/>
    <dbReference type="InParanoid" id="B8M920"/>
    <dbReference type="OrthoDB" id="4159828at2759"/>
    <dbReference type="PhylomeDB" id="B8M920"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="49"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="472" mass="52623" checksum="BC9A3AD0B721682A" modified="2009-03-03" version="1">MSKRRKASRPPSYAPLQLTLKKPRISCSFRFFRPQESCSRVGEAAKALTTLPEVYFPQTTILAGNLNLLHNRWQPSLQHSPTTFAELFINWLDLQGLVLISDIDCPTHERGNVLDLSFASSPLALAGAKASIASHLDATSDHQPLITTVPWDQRYKETAQKLRFDTLDHTSFLSLLASNLASTESSAVTEEDLDALAEKLTSAIQGAYRGSAKRTITQGIEQPWPLLKDRLPQDNKMLSMATQMKDVFDMSTFRSPPLKDPLRPNSFPAVTIHEKRDVLVRNLLQNSAEARDIPLDSPAVPTTSLYFLDITMAQVEESVLQAGNTAPSSDKIPTCILKVAWPLIKDKKSKKTDWSSPRLYRPIALLSVLGEGLERLMAWNMAWISIHYKVLARQQFRALPLRSANDLTTCLTHDVEQALNQGMTTSLLTLDVKGAFNAVLPGRLIRRLCEQGWPTNLVLWIASFATGRSVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8M927</accession>
    <name>B8M927_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_111580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481314.1">
        <property type="nucleotide sequence ID" value="XM_002481269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M927"/>
    <dbReference type="GeneID" id="8098813"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_111580"/>
    <dbReference type="HOGENOM" id="CLU_1961059_0_0_1"/>
    <dbReference type="InParanoid" id="B8M927"/>
    <dbReference type="PhylomeDB" id="B8M927"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="128" mass="14326" checksum="D327AA97DD5E7750" modified="2009-03-03" version="1">MSLRDALDSSVETTPLRAQSNAPRDESIIASLEADTNEETDDNEDSVSEDDDLPVVVPDRPPENRLLRNTPLSESTLFNSLDIEIAATNLYNAKEDFKKLSAKQRIKVTEHTLRKAWKDISIVNTSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8M930</accession>
    <name>B8M930_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dynamin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_111610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481317.1">
        <property type="nucleotide sequence ID" value="XM_002481272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M930"/>
    <dbReference type="STRING" id="441959.B8M930"/>
    <dbReference type="GeneID" id="8098816"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_111610"/>
    <dbReference type="eggNOG" id="KOG0446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008964_7_2_1"/>
    <dbReference type="InParanoid" id="B8M930"/>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="PhylomeDB" id="B8M930"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF215">
        <property type="entry name" value="DYNAMIN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin GTPase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="351"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED17325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="643" mass="73114" checksum="591E22DCA5B39CB5" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9E2</accession>
    <name>B8M9E2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_115030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the aldehyde dehydrogenase family.</text>
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        <property type="protein sequence ID" value="EED17702.1"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_3_1_1"/>
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    <dbReference type="OrthoDB" id="440325at2759"/>
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    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018484">
        <property type="term" value="F:4-hydroxybenzaldehyde dehydrogenase (NAD+) activity"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047770">
        <property type="term" value="F:carboxylate reductase activity"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:aldehyde catabolic process"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:sphingolipid metabolic process"/>
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    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF11">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="3 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED17702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="525" mass="58657" checksum="271964CB167BB5F9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9H2</accession>
    <name>B8M9H2_TALSN</name>
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        <recommendedName>
            <fullName evidence="1">asparaginase</fullName>
            <ecNumber evidence="1">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_115310</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the asparaginase 1 family.</text>
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    <dbReference type="EC" id="3.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481724.1">
        <property type="nucleotide sequence ID" value="XM_002481679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9H2"/>
    <dbReference type="STRING" id="441959.B8M9H2"/>
    <dbReference type="GeneID" id="8101341"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_115310"/>
    <dbReference type="eggNOG" id="KOG0503">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019134_3_1_1"/>
    <dbReference type="InParanoid" id="B8M9H2"/>
    <dbReference type="OMA" id="CDVGVIP"/>
    <dbReference type="OrthoDB" id="542841at2759"/>
    <dbReference type="PhylomeDB" id="B8M9H2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009066">
        <property type="term" value="P:aspartate family amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08963">
        <property type="entry name" value="L-asparaginase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1170:FF:000003">
        <property type="entry name" value="60 kDa lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.40:FF:000001">
        <property type="entry name" value="L-asparaginase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000284">
        <property type="entry name" value="Lysophospholipase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041725">
        <property type="entry name" value="L-asparaginase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00057">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="8">
        <location>
            <begin position="20"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="9">
        <location>
            <begin position="260"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="441"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="474"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="531"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="531"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED17732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="567" mass="61517" checksum="2CA58BE524FB3D00" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>B8MA48</accession>
    <name>B8MA48_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_121210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482369.1">
        <property type="nucleotide sequence ID" value="XM_002482324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MA48"/>
    <dbReference type="FunCoup" id="B8MA48">
        <property type="interactions" value="80"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MA48"/>
    <dbReference type="GeneID" id="8099361"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_121210"/>
    <dbReference type="eggNOG" id="KOG0789">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001645_11_0_1"/>
    <dbReference type="InParanoid" id="B8MA48"/>
    <dbReference type="OMA" id="WQQDVRV"/>
    <dbReference type="OrthoDB" id="6058203at2759"/>
    <dbReference type="PhylomeDB" id="B8MA48"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01446">
        <property type="entry name" value="DSP_MapKP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18533">
        <property type="entry name" value="PTP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein tyrosine phosphatase (Pyp1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000142">
        <property type="entry name" value="Protein tyrosine phosphatase (Pyp1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF561">
        <property type="entry name" value="PROTEIN TYROSINE PHOSPHATASE 36E, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="6">
        <location>
            <begin position="289"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="541"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="722"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="205"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="650"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="781"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="651"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="788"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED18377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="847" mass="94118" checksum="A94E2A00199F0D8D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MA72</accession>
    <name>B8MA72_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_121440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED18401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002482348.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="8099384"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_121440"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039545_0_0_1"/>
    <dbReference type="InParanoid" id="B8MA72"/>
    <dbReference type="OrthoDB" id="4226915at2759"/>
    <dbReference type="PhylomeDB" id="B8MA72"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="189"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED18401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="57374" checksum="933430448C35FEFC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAL5</accession>
    <name>B8MAL5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_112710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481431.1">
        <property type="nucleotide sequence ID" value="XM_002481386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAL5"/>
    <dbReference type="STRING" id="441959.B8MAL5"/>
    <dbReference type="GeneID" id="8105736"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_112710"/>
    <dbReference type="eggNOG" id="ENOG502QTM1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030671_1_0_1"/>
    <dbReference type="InParanoid" id="B8MAL5"/>
    <dbReference type="OMA" id="TGWWTRF"/>
    <dbReference type="OrthoDB" id="5396at2759"/>
    <dbReference type="PhylomeDB" id="B8MAL5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF10">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="40431" checksum="66C0C1BF7657AAFB" modified="2009-03-03" version="1">MEMYIKRDTLNLIRHLISIFDMSTERKQDPNSTLWDPDNTTFPLRSELPALAGAPKDAAWVWGPNDNLGRLNLVTPSRIVSAATEIKSGESCRVDLPLSIPVKPSFGRETFKHDIKVIEGGVGHDDLYTLNTQSGTQWDGFRHISHAPSKLFYNNTRASDITGSDANDKCGIHHWAQRGIAGRGVLLDFVSYAEKHDIKYDSASSYAISFEDLVSCGQFQGLDIRPAAQGGDIQVGDILFIRSGFVRDYFSRTEEENIQIGSRQDHIWAGVKQEQEMIDWLHNCYFAAVAGDAPAFERWPSPESYKLHEYLLALWGVPIGEMLALEGVSVLAKKHQRWTFFFTTAPANCPGGVGSHVNGTAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAS8</accession>
    <name>B8MAS8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_115630</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481760.1">
        <property type="nucleotide sequence ID" value="XM_002481715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAS8"/>
    <dbReference type="FunCoup" id="B8MAS8">
        <property type="interactions" value="446"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MAS8"/>
    <dbReference type="GeneID" id="8099590"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_115630"/>
    <dbReference type="eggNOG" id="KOG2115">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003094_1_0_1"/>
    <dbReference type="InParanoid" id="B8MAS8"/>
    <dbReference type="OMA" id="QKQAVML"/>
    <dbReference type="OrthoDB" id="10259024at2759"/>
    <dbReference type="PhylomeDB" id="B8MAS8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012501">
        <property type="entry name" value="Vps54_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019515">
        <property type="entry name" value="VPS54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07928">
        <property type="entry name" value="Vps54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10475">
        <property type="entry name" value="Vps54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 N-terminal" evidence="10">
        <location>
            <begin position="279"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 C-terminal" evidence="9">
        <location>
            <begin position="825"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="539"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="620"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="791"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1070"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="550"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="627"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="795"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1076"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1097"/>
            <end position="1108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED17768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1108" mass="122555" checksum="D1F9FFA7689552A6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAU2</accession>
    <name>B8MAU2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_115760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481774.1">
        <property type="nucleotide sequence ID" value="XM_002481729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAU2"/>
    <dbReference type="STRING" id="441959.B8MAU2"/>
    <dbReference type="GeneID" id="8099603"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_115760"/>
    <dbReference type="eggNOG" id="ENOG502RZVZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079143_0_0_1"/>
    <dbReference type="InParanoid" id="B8MAU2"/>
    <dbReference type="OMA" id="EAHQYQA"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="PhylomeDB" id="B8MAU2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="106"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED17782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="260" mass="30514" checksum="500673A98C5C7750" modified="2009-03-03" version="1">MFRRALYIPRQSASLTGYHRLIPAIIFFTPPQPRRQFHSSSAQFNKPIKGTIYKMRDEVKDAVSSSNSHLDSSIAEDPSERHIDESWKLRAPYQIQKDEEFGPVKWEAMCHCGNVQYQIKRERPLAAKYCHCRACQVLHAAPFQWCAIFFKTDIRFKKGTDSLMFWSSHEKSKKYQVPTKVYCSNCNSPIMDEGRNMCLIFPELIDLGKTEEEHLVRRKVFEIDHHIFYSRRLVEVHDGKPKWSELDDKSNRLDDDGNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBS7</accession>
    <name>B8MBS7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS sugar transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_119700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482202.1">
        <property type="nucleotide sequence ID" value="XM_002482157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBS7"/>
    <dbReference type="GeneID" id="8105245"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119700"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_43_5_1"/>
    <dbReference type="InParanoid" id="B8MBS7"/>
    <dbReference type="OMA" id="TRTHAKY"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="PhylomeDB" id="B8MBS7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000474">
        <property type="entry name" value="Sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF14">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="515"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="115"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED18210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="652" mass="72317" checksum="75D68147E3A3A683" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBV7</accession>
    <name>B8MBV7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 17">Elongator complex protein 3</fullName>
            <ecNumber evidence="17">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TSTA_119960</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17 18">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17 18">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the ELP3 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="17"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482232.1">
        <property type="nucleotide sequence ID" value="XM_002482187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBV7"/>
    <dbReference type="FunCoup" id="B8MBV7">
        <property type="interactions" value="1033"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MBV7"/>
    <dbReference type="GeneID" id="8105270"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119960"/>
    <dbReference type="eggNOG" id="KOG2535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025983_2_1_1"/>
    <dbReference type="InParanoid" id="B8MBV7"/>
    <dbReference type="OMA" id="TFETRPD"/>
    <dbReference type="OrthoDB" id="10265243at2759"/>
    <dbReference type="PhylomeDB" id="B8MBV7"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140018">
        <property type="term" value="P:regulation of cytoplasmic translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000003">
        <property type="entry name" value="Elongator complex protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056591">
        <property type="entry name" value="ELP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23613">
        <property type="entry name" value="ELP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15 17 21" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="12 18" id="KW-0408">Iron</keyword>
    <keyword evidence="13 17 18" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 17" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 17 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8 17" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 17" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Radical SAM core" evidence="20">
        <location>
            <begin position="100"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="19">
        <location>
            <begin position="414"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EED18240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="570" mass="64402" checksum="D4F9EA2712DD7019" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCD2</accession>
    <name>B8MCD2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_123080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482570.1">
        <property type="nucleotide sequence ID" value="XM_002482525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCD2"/>
    <dbReference type="GeneID" id="8108223"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_123080"/>
    <dbReference type="eggNOG" id="ENOG502RQWM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_809355_0_0_1"/>
    <dbReference type="InParanoid" id="B8MCD2"/>
    <dbReference type="OMA" id="CIEHHRR"/>
    <dbReference type="OrthoDB" id="3832628at2759"/>
    <dbReference type="PhylomeDB" id="B8MCD2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED18578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="343" mass="39969" checksum="F9972CA9E674830D" modified="2009-03-03" version="1">MARTKQIARKSTGGRAPRKQLGSKDFSRHTFLDHAQKPYTVVGGPSWSMNQDIIRKLSLHLYFLSDVDPDQGAEIGNSLLRSDAICGWGNARNYWPRVDVYAPLGSIEECIEHHRREKIFRRKAVEEMHAAVAAAARDACGPEMDDEDREEAAHEAVLALRGKEVYPHIVPTWCCSAKFWREYDYKKRYRSFVLVVPADCHSWDDILQKGIIHVEFDQDVSPAMETYMDDTYGEEEESLIENDRTGWVYIEKSPDEIRGHLYHRWMDHTSALWDCTYRIPVCDACNNEEPHQNCEHELNGHYFDEDGQCIACRRHTEYRRRSKRIAKRQKQDDVADKRHNLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCN6</accession>
    <name>B8MCN6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_126460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482930.1">
        <property type="nucleotide sequence ID" value="XM_002482885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCN6"/>
    <dbReference type="STRING" id="441959.B8MCN6"/>
    <dbReference type="GeneID" id="8099073"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_126460"/>
    <dbReference type="eggNOG" id="ENOG502R6TN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108113_0_0_1"/>
    <dbReference type="InParanoid" id="B8MCN6"/>
    <dbReference type="OMA" id="WTNEYAI"/>
    <dbReference type="OrthoDB" id="3758478at2759"/>
    <dbReference type="PhylomeDB" id="B8MCN6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050977">
        <property type="entry name" value="Fungal_Meroterpenoid_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39598:SF1">
        <property type="entry name" value="AUSTINOID BIOSYNTHESIS CLUSTERS PROTEIN F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39598">
        <property type="entry name" value="AUSTINOL SYNTHESIS PROTEIN F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="17078" checksum="FCF5F1FE5336A027" modified="2009-03-03" version="1">MPASIDVQKETISKFLAAWESGKAQDTIDLWADDFEQRLLPLSLQQPVRTRAHAQFIYPKLVENLKNWKLNIKNIVHDAANGTAAVYATSSADTPVPEEKWTNEYAIFVWLTEDGMKVKRLEEMVDSAFYQHFFPKFQNYLVEQGLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCP4</accession>
    <name>B8MCP4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_126540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482938.1">
        <property type="nucleotide sequence ID" value="XM_002482893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCP4"/>
    <dbReference type="GeneID" id="8099081"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_126540"/>
    <dbReference type="eggNOG" id="ENOG502S2ZX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_4_3_1"/>
    <dbReference type="InParanoid" id="B8MCP4"/>
    <dbReference type="OMA" id="HESWRIG"/>
    <dbReference type="OrthoDB" id="6115549at2759"/>
    <dbReference type="PhylomeDB" id="B8MCP4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="60"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED18946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="537" mass="61404" checksum="773B6170BF56D6A9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MD27</accession>
    <name>B8MD27_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit WBP1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_113730</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DDOST 48 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481545.1">
        <property type="nucleotide sequence ID" value="XM_002481500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MD27"/>
    <dbReference type="FunCoup" id="B8MD27">
        <property type="interactions" value="1037"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MD27"/>
    <dbReference type="GeneID" id="8101685"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_113730"/>
    <dbReference type="eggNOG" id="KOG2754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031804_1_0_1"/>
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    <dbReference type="OMA" id="AHDEYPR"/>
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    <dbReference type="PhylomeDB" id="B8MD27"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005013">
        <property type="entry name" value="DDOST_48_kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055459">
        <property type="entry name" value="OST48_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055457">
        <property type="entry name" value="OST48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23358">
        <property type="entry name" value="OST48_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03345">
        <property type="entry name" value="OST48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005124110" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1" evidence="8">
        <location>
            <begin position="20"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 N-terminal" evidence="9">
        <location>
            <begin position="26"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 middle" evidence="10">
        <location>
            <begin position="308"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED17553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="462" mass="51451" checksum="2FB1C4861371E907" modified="2009-03-03" version="1">MRSFLSFLLLGFWGACVHALSSSGSRLLVVLEEDKNLYSNLWADLEDRGYDITFESPKSDKLSLFAHGEKAYDHLILLPSKSKGLGPALTPKLLLDFVNNEGNVLLALSGKSTTPSSINSLLLELDLHISPDRSSIVIDHFNYDTISASEKHDVLLLPLPDPVRSDVKSFFSGEGVLAFPRPVGQSLGNASPLLTPIVRAPETAYSYNTKEDSLSVEDSFATGSQLALVSALQARNSARFTVLGSAEALEDKWFSASVKAPKSKSAVTTANRQFAKQLTAWTFQELGVLKVGKIEHYLSDEFGNIEGAVNPKIYRIKNDVTFDIEVSEYEFDKWIPYKVPANDELQLEFTMLSPWHRLKLLPKSSTLNSTVFGVTFTTPDQHGIFSFRVNYNRPFLTNIEEKHEVTVRHFAHDEYPRSWQITGGWVWIAGLWSVIGGFIAFVLVWLYSAPVLSAEAKVQKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEJ1</accession>
    <name>B8MEJ1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_016930</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002483807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEJ1"/>
    <dbReference type="STRING" id="441959.B8MEJ1"/>
    <dbReference type="GeneID" id="8103666"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_016930"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_11_1"/>
    <dbReference type="InParanoid" id="B8MEJ1"/>
    <dbReference type="OMA" id="VAVWHWA"/>
    <dbReference type="OrthoDB" id="4219675at2759"/>
    <dbReference type="PhylomeDB" id="B8MEJ1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000047">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF230">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED16618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="515" mass="58905" checksum="2D1F2C6A267F6BF1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8MER0</accession>
    <name>B8MER0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ion channel nompc, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_020020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484177.1">
        <property type="nucleotide sequence ID" value="XM_002484132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MER0"/>
    <dbReference type="STRING" id="441959.B8MER0"/>
    <dbReference type="GeneID" id="8108813"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_020020"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_48_0_1"/>
    <dbReference type="InParanoid" id="B8MER0"/>
    <dbReference type="OMA" id="ANIHIMN"/>
    <dbReference type="OrthoDB" id="4223509at2759"/>
    <dbReference type="PhylomeDB" id="B8MER0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902495">
        <property type="term" value="C:transmembrane transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052076">
        <property type="entry name" value="TRP_cation_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143:SF1">
        <property type="entry name" value="ION_TRANS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="F-box" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="208"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED16943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="367" mass="39614" checksum="6CC28EB50E30880F" modified="2009-03-03" version="1">MSFLSLPPELLALVASFLERDSDINSLSQVNRRLNFLLVPKLYRHNVRNGSCSALLWAAKHGIKGTAEKNSLGRTAISFAAEHGHEAVVRCLLETGPVDPELGDNLNEGPLSYAAENGHVGVVRLLLAMDMKDLDSKDISGTTPLSRACENGHLTVAKMLIKTERVDVNSRNVSGQTPLSLAAENGHGTVVRLLLKDARVDVNSMNSRRRTPLSLASENGHVTVVRALLQDGRLGDSTDGHGRTPLSWAAENGHGPVVKLLLKVKDIDVNSRDVVFQTPLSLAAENGHNTVVKILLKDSRVDVDARDATGSTPLSLASRNGHCAVVQLLLDTKRVDVDAKNHNGLTPIFLAVVNNHEKVKDLLLNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8MER1</accession>
    <name>B8MER1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_020030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484178.1">
        <property type="nucleotide sequence ID" value="XM_002484133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MER1"/>
    <dbReference type="FunCoup" id="B8MER1">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MER1"/>
    <dbReference type="GeneID" id="8108814"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_020030"/>
    <dbReference type="eggNOG" id="KOG0927">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_45_1_1"/>
    <dbReference type="InParanoid" id="B8MER1"/>
    <dbReference type="OMA" id="VRYYMRL"/>
    <dbReference type="OrthoDB" id="10255969at2759"/>
    <dbReference type="PhylomeDB" id="B8MER1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00267">
        <property type="entry name" value="ABC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050334">
        <property type="entry name" value="Molybdenum_import_ModC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43514">
        <property type="entry name" value="ABC TRANSPORTER I FAMILY MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43514:SF4">
        <property type="entry name" value="ABC TRANSPORTER I FAMILY MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="145"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="420"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="793"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="808"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED16944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="844" mass="95887" checksum="8EC86A9093A41C87" modified="2009-03-03" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEW6</accession>
    <name>B8MEW6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_023030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484483.1">
        <property type="nucleotide sequence ID" value="XM_002484438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEW6"/>
    <dbReference type="STRING" id="441959.B8MEW6"/>
    <dbReference type="GeneID" id="8107140"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_023030"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_22_1"/>
    <dbReference type="InParanoid" id="B8MEW6"/>
    <dbReference type="OMA" id="HEKSCER"/>
    <dbReference type="OrthoDB" id="4223623at2759"/>
    <dbReference type="PhylomeDB" id="B8MEW6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="299" mass="33173" checksum="6C8584164DBCD9B6" modified="2009-03-03" version="1">METPSKNEFQIGWICRIGQHHVVIACLPDRQYGTTSATTVANNMMRTFSVSLRIGLMVGISGGAPSAEHDIRLGDIIVSRPKGSHGGVIQHDIGKIGKGGKIQRVGSLNSPPTSLLNALAQMRVAELYENPQYPVYLQEAIRRNTRTQKTFSRPDVKSDRLFKIEYEHPENAASYDQCLVEWEEDRITREDGDPQTHYRTIASGNTLIKDGKTREAIRKDTGALCFEMEAAGLMADFPCLVVRGICDYADSHKNKQWQGYTALAAASFTKELLGYVPKGVSQESLVTDICPLLEDIKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFQ6</accession>
    <name>B8MFQ6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_021070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484280.1">
        <property type="nucleotide sequence ID" value="XM_002484235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFQ6"/>
    <dbReference type="GeneID" id="8109364"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_021070"/>
    <dbReference type="eggNOG" id="ENOG502SF95">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_850214_0_0_1"/>
    <dbReference type="InParanoid" id="B8MFQ6"/>
    <dbReference type="OrthoDB" id="5230585at2759"/>
    <dbReference type="PhylomeDB" id="B8MFQ6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080">
        <property type="entry name" value="SRR1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080:SF3">
        <property type="entry name" value="SRR1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="1">
        <location>
            <begin position="152"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="327" mass="37149" checksum="F8D2DE7015791B68" modified="2009-03-03" version="1">MSDRADKIRDLYLKGKELFPRQTMEVMGKILKGYKTGKCKNADFIIPDYVDGNESPHPNEVTLDLGYHVHVEGAKLKAMGYVPIQMFRLGLGHQITVLESDFDKAYAQNLKAPKAHDIQELENLRDEAYKNWIMNPARDSVQATLKGIKIGKLKKVTKIIAFGNGSLWYGWKREMGLIKNFVAQHAVIQEIRDFIQKTCNQEVTCYAQEPKYTPADEKVLLAHFGIQPLEEIEALLQVDEKTLVFAMNQDMPLLQILADISKPPAMILCGEVNITEKLEDYDSKKMSACPTSPRVQSLIHSYLEPLKIDDTDSLFESGNKTRLYVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8MG49</accession>
    <name>B8MG49_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-oxoacyl-[acyl-carrier-protein] reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_010340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483150.1">
        <property type="nucleotide sequence ID" value="XM_002483105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MG49"/>
    <dbReference type="STRING" id="441959.B8MG49"/>
    <dbReference type="GeneID" id="8105673"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_010340"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_8_2_1"/>
    <dbReference type="InParanoid" id="B8MG49"/>
    <dbReference type="OMA" id="MAVYRLW"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="PhylomeDB" id="B8MG49"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="32"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED15916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="305" mass="33107" checksum="1420708E5797C882" modified="2009-03-03" version="1">MAAPFPSPTAKWHTTTYPTLSPARPELSAKGRTVLITGGGTGIGAETARYFAQAGASRIALLGRREQPLLDTKASIEQINGDVDVFVAPTDITNKEQVDAAFDRFVGGDQPGKIDILISNAAIVGPLNPISSVDADQFLDAINVIIKGSLYVAQAFLRHAVPQDAVIVETNSSAAHLNFAPAFVSYSVAKLAVYRLWDSLGFEFEKAGMRVYHVQPGVVNTDMNKEAGGVKAVGFEDHVSLPASFNLWLTSPEAKFLKGKFLWANWDVDELKIRAKEIEEGSEFNIQVVGWPFGEKNWKSGWQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MG81</accession>
    <name>B8MG81_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ELMO/CED-12 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_010640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483182.1">
        <property type="nucleotide sequence ID" value="XM_002483137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MG81"/>
    <dbReference type="STRING" id="441959.B8MG81"/>
    <dbReference type="GeneID" id="8109837"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_010640"/>
    <dbReference type="eggNOG" id="KOG2999">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009191_0_0_1"/>
    <dbReference type="InParanoid" id="B8MG81"/>
    <dbReference type="OMA" id="CPHMKDL"/>
    <dbReference type="OrthoDB" id="28413at2759"/>
    <dbReference type="PhylomeDB" id="B8MG81"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024574">
        <property type="entry name" value="ELMO_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF56">
        <property type="entry name" value="CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11841">
        <property type="entry name" value="ELMO_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="2" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0729">SH3-binding</keyword>
    <feature type="domain" description="ELMO" evidence="6">
        <location>
            <begin position="251"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="256"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="592"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="642"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="592"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="603"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED15948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="755" mass="84365" checksum="6D141B441166C07E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGU5</accession>
    <name>B8MGU5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_014220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483560.1">
        <property type="nucleotide sequence ID" value="XM_002483515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGU5"/>
    <dbReference type="GeneID" id="8107805"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_014220"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_1_4_1"/>
    <dbReference type="InParanoid" id="B8MGU5"/>
    <dbReference type="OMA" id="WKEVITQ"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="PhylomeDB" id="B8MGU5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF12">
        <property type="entry name" value="STERIGMATOCYSTIN 8-O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="248"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED16326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="420" mass="46516" checksum="205BAB11B89CFB15" modified="2009-03-03" version="1">MASAQSRIAELATTVAQHTRRIDSYLAEKDLPYPSFDAGGPVDLGLPPEIEESRTIVLEASQELNDLLQGPRDLLFNHQHNLLAYLKLISRFDLASKVPITGEITFVDLAATVGVDRAALTSILRLGIAHRIFREPRPGFIAHSAASRLIAEDTRVASWVGANVDDMWPAAEKVVDALVKWPLAEEPNQTGFALANGTDQSFYAELEKNPDRARRFGGAMSFFTTGDEYSLRHLTDGYDWGSIGSGGTVVDLGGSHGDAAFALARKYPGLHLIVQELPQVVANSKEEFGLDVKFMVHDFFEEQPVHGADAYLFRWTLHNWPDKYCIKALRALIPALKAGARVLIADFVMPPPGVLPNLLDRKLRAMDLTMLEIGNSKERALDEWISLFAQADSRFIFKGMRQPPGSRLAILEVTWELENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHF7</accession>
    <name>B8MHF7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF895 domain membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_021930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484370.1">
        <property type="nucleotide sequence ID" value="XM_002484325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHF7"/>
    <dbReference type="GeneID" id="8098459"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_021930"/>
    <dbReference type="eggNOG" id="KOG3098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030884_2_0_1"/>
    <dbReference type="InParanoid" id="B8MHF7"/>
    <dbReference type="OMA" id="NRFGNVW"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="PhylomeDB" id="B8MHF7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF19">
        <property type="entry name" value="DUF895 DOMAIN MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED17136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="52319" checksum="6A1DCE5A10934217" modified="2009-03-03" version="1">MAHSIENGPDDISVKRVWYRSSLFNACVIGAVGFLAPGLWNAMNSLGAGGEEKPFLVNAANSLVFGLMGIFCLFGAPIANRIGLKWTLLLGAIGYPIYSAGLYTNNRFGTVWLVLFGSATCGISAGLFWASEGAIAIGYPEPAKRARYLNIWVWWRTLGPLVGDSIVLALNINSSGIGSISHTTYLVFIVLQCLAAPVAFLLTSPAKVQRGDGSRVIIVVEKSWKDEFKALWRTCKNPTVVLLLPIFWAVYFNQYTGNFKAYYFGVRARALMAFVTDVVTIIGSQTMSHWLDSKITNAKKRVVYGWYWVVFVHVVTWIYAWVIQGEFISHPPKLDYKSPGFVKGAFAVWLWAFAQQTAQNWLYYIVGSMTDNIAELTRLTGILRGQESFGQAVSYGLNSKKWYGGRVPMAVNTILLGLCVVPTWIVVHRHDPEDFTKKYTQRQDSEGDTASGEEVIVSSELKAHSAELRKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MI45</accession>
    <name>B8MI45_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_022610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484441.1">
        <property type="nucleotide sequence ID" value="XM_002484396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MI45"/>
    <dbReference type="STRING" id="441959.B8MI45"/>
    <dbReference type="GeneID" id="8107098"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_022610"/>
    <dbReference type="eggNOG" id="KOG3105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_4_0_1"/>
    <dbReference type="InParanoid" id="B8MI45"/>
    <dbReference type="OMA" id="CQNNTID"/>
    <dbReference type="OrthoDB" id="4502298at2759"/>
    <dbReference type="PhylomeDB" id="B8MI45"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="57"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED17207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="431" mass="47972" checksum="F4F620F7A40FBBEC" modified="2009-03-03" version="1">MVKSRTKNDPSYEGRLSLAIDALNNEKITKLRDAARTFDVSLTTLRRRLKGSVPAHNAGITRRKMTPTEEAVLRGWVFSLERRGVPPRQHMLHEMANILLAQRDPTKIPEKVGKNWVTTFLKRQPDLKAKFARRLSYSRALCEDPVVIGGFFEEIKQLKEEYGIADEDIYNFDETGFAMGISSTAKVICSSDRSGKPSLIQPGNREWVTVVECVGSTGTVVPPLIIFKSGTNRAECVRIQTYTTQNIKSGFSHTGIVPYNLQKVLSQLQIAVREATPASIRPSTSSSSTWSPKTPYNARTLEKQAKSVKRSLNMGDLDSNSPSCPAFNQLIKGSLVVMHQAAILARENHNLREANDILQKRRTRRTKALQADGILTVAEGRELAQELPEEAQPPPPPNGSAPLQPAQRALPRCSNCWEIGHKRNRCPNIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIN1</accession>
    <name>B8MIN1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">O-acetylhomoserine aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="12">2.5.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSTA_045800</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-acetyl-L-homoserine + hydrogen sulfide = L-homocysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:27822"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="2.5.1.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-acetyl-L-homoserine + methanethiol = L-methionine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10048"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16007"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="EC" id="2.5.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from O-acetyl-L-homoserine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.49" evidence="12"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485076.1">
        <property type="nucleotide sequence ID" value="XM_002485031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIN1"/>
    <dbReference type="FunCoup" id="B8MIN1">
        <property type="interactions" value="194"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MIN1"/>
    <dbReference type="GeneID" id="8107567"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_045800"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_4_0_1"/>
    <dbReference type="InParanoid" id="B8MIN1"/>
    <dbReference type="OMA" id="NAFQIIQ"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="PhylomeDB" id="B8MIN1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051009">
        <property type="term" value="F:O-acetylhomoserine sulfhydrylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071269">
        <property type="term" value="P:L-homocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000083">
        <property type="entry name" value="O-acetylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000035">
        <property type="entry name" value="O-succinylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797">
        <property type="entry name" value="HOMOCYSTEINE/CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797:SF2">
        <property type="entry name" value="HOMOCYSTEINE_CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7 13 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EED15123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="457" mass="48633" checksum="1E8CF711B5B1548A" modified="2009-03-03" version="1">MAGQRFETLQLHAGQEPDPATNSRAVPIYATTSYVFNDSAHGARLFGLKEFGNIYSRIMNPTVDVFEKRIAALEGGVAAVAASSGQAAQFMAISALAHAGDNIVATSNLYGGTYNQLKVFLPRLGIQTKFVNGDNADDIAAAIDDRTKAVYVETIGNPRYNVPDFEAIAKVAHEKGVPLVVDNTFGAGGYFARPIDHGADIVVHSATKWIGGHGTTIGGVVIDSGKFDWGKNAARFPQFVEPAEGYHGLKFWETFGPITFAIRTRVEILRDLGSALNPFAAQQLLLGLETLSLRAERHASNALTLARWLEKNENVAWVSYPGLESHASHETAKKYLPRGFGGVLSFGVKGGAAAGSQVVDGFKLISNLANVGDSKTLAIHPWSTTHEQLSEKERIASGVTEDAIRISVGTEHIDDIIADFEQSFKAASAAGADKTALPDRASGGAATEHETGLQGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIW2</accession>
    <name>B8MIW2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_050620</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485577.1">
        <property type="nucleotide sequence ID" value="XM_002485532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIW2"/>
    <dbReference type="SMR" id="B8MIW2"/>
    <dbReference type="FunCoup" id="B8MIW2">
        <property type="interactions" value="1230"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MIW2"/>
    <dbReference type="GeneID" id="8109104"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_050620"/>
    <dbReference type="eggNOG" id="KOG3467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109117_2_3_1"/>
    <dbReference type="InParanoid" id="B8MIW2"/>
    <dbReference type="OMA" id="XRISAMI"/>
    <dbReference type="OrthoDB" id="4222081at2759"/>
    <dbReference type="PhylomeDB" id="B8MIW2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000007">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="14">
        <location>
            <begin position="36"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED15624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="103" mass="11386" checksum="2696CB0E75674EFF" modified="2009-03-03" version="1">MTGRGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISAMIYEETRGVLKSFLESVIRDAVTYTEHAKRKTVTSLDVVYALKRQGRTLYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJ58</accession>
    <name>B8MJ58_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_051570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485673.1">
        <property type="nucleotide sequence ID" value="XM_002485628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJ58"/>
    <dbReference type="STRING" id="441959.B8MJ58"/>
    <dbReference type="GeneID" id="8103378"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_051570"/>
    <dbReference type="HOGENOM" id="CLU_028200_0_1_1"/>
    <dbReference type="InParanoid" id="B8MJ58"/>
    <dbReference type="OrthoDB" id="4223615at2759"/>
    <dbReference type="PhylomeDB" id="B8MJ58"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="112"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED15720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="222" mass="24687" checksum="86F7BE8C3ACD26C0" modified="2009-03-03" version="1">MVGLRLAAVQYFGHGIHAVDLPQETVIKFNKSFIVVQMLYFADVVTTKAAFVGKIAIPTAFLFLYYRIFGVMFGSGARYISLRSYLSRSSLLARPSPWPDVIPYRTTGINISLGNGIANIILNFVIFCLPVPMTLRLNTTVRQKLIISSIFILGFFVYVVSNIRIIAFSGSNPKDMTWSTVPTATWSSIEQAVSIICTCLPTLRPLFTSFYGSTSSNSKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJH2</accession>
    <name>B8MJH2_TALSN</name>
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        <submittedName>
            <fullName evidence="7">Heme/steroid binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_046260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485125.1">
        <property type="nucleotide sequence ID" value="XM_002485080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJH2"/>
    <dbReference type="STRING" id="441959.B8MJH2"/>
    <dbReference type="GeneID" id="8099537"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_046260"/>
    <dbReference type="eggNOG" id="KOG0536">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046313_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJH2"/>
    <dbReference type="OMA" id="KECLAQQ"/>
    <dbReference type="OrthoDB" id="432299at2759"/>
    <dbReference type="PhylomeDB" id="B8MJH2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000001">
        <property type="entry name" value="Cytochrome b5 reductase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="187"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED15172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="282" mass="30151" checksum="44AB87DC096B8B7F" modified="2009-03-03" version="1">MWSLTSLFTRSAQQAEVTQAKSDDVQQDNAHSETDSTQTTPKASAIVSTVQVPELNLQESDKSSDQTDQDAPTITSSSTPTTNNASLMLPPSAPTQRRPPTLKPVNQPFLAPPKLKASSLRPTSLSAASALRAPPATTNGLTTSTLAPSQRASRKVILGPGHSPLDWAALTKDPRNNLRGANLPPTLIKVTPSMLKSQNGRKGTDAWTSYNGKVYNITPYVSFHPGGKGELLRGAGKDSGKLFLETHPWVNWDGILGECLVGILVSENEKGDDETNELDAMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKB2</accession>
    <name>B8MKB2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_047180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485220.1">
        <property type="nucleotide sequence ID" value="XM_002485175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKB2"/>
    <dbReference type="STRING" id="441959.B8MKB2"/>
    <dbReference type="GeneID" id="8098511"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_047180"/>
    <dbReference type="eggNOG" id="ENOG502SQ74">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_370030_0_0_1"/>
    <dbReference type="InParanoid" id="B8MKB2"/>
    <dbReference type="OMA" id="EFYMYST"/>
    <dbReference type="OrthoDB" id="5383784at2759"/>
    <dbReference type="PhylomeDB" id="B8MKB2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="782" mass="87931" checksum="13CFF4C8C2384031" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLD9</accession>
    <name>B8MLD9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_045170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485007.1">
        <property type="nucleotide sequence ID" value="XM_002484962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLD9"/>
    <dbReference type="GeneID" id="8099481"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_045170"/>
    <dbReference type="HOGENOM" id="CLU_453547_0_0_1"/>
    <dbReference type="InParanoid" id="B8MLD9"/>
    <dbReference type="OrthoDB" id="5413281at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="576"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED15054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="602" mass="67457" checksum="76A7387CAA5B5A56" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLF8</accession>
    <name>B8MLF8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_049280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485444.1">
        <property type="nucleotide sequence ID" value="XM_002485399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLF8"/>
    <dbReference type="STRING" id="441959.B8MLF8"/>
    <dbReference type="GeneID" id="8100644"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_049280"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1361227_0_0_1"/>
    <dbReference type="InParanoid" id="B8MLF8"/>
    <dbReference type="OrthoDB" id="4523547at2759"/>
    <dbReference type="PhylomeDB" id="B8MLF8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED15491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="23618" checksum="3AA43EA78977681E" modified="2009-03-03" version="1">MPRSPKSLVETRSIVRAFAAFFGSGAISDIWPRLDRSYMFAIYVYIVFAGPLLASIIGPILIDRYRVTIFPVQITFISFVWGIAVLLMPETYVPVILYWKARQFRKLTRQLKFKAPIELKRVKFRRRMKHDLNRPFRFLYKDRMLTLVVAYTGLNYIITYQMFSAVPLLYSTDYKFDLLMWVLLSYPPLTLLQQSSGIIGY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLN6</accession>
    <name>COQ4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquinone biosynthesis protein coq4, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase</fullName>
            <ecNumber evidence="1">4.1.1.130</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Coenzyme Q biosynthesis protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">coq4</name>
        <name type="ORF">TSTA_101390</name>
    </gene>
    <organism>
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid into 2-methoxy-6-(all-trans-polyprenyl)phenol during ubiquinone biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + H(+) = a 2-methoxy-6-(all-trans-polyprenyl)phenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:81179"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="4.1.1.130"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of a multi-subunit COQ enzyme complex, composed of at least coq3, coq4, coq5, coq6, coq7 and coq9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">This protein may be expected to contain an N-terminal transit peptide but none has been predicted.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ4 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.130" evidence="1"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486137.1">
        <property type="nucleotide sequence ID" value="XM_002486092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLN6"/>
    <dbReference type="SMR" id="B8MLN6"/>
    <dbReference type="FunCoup" id="B8MLN6">
        <property type="interactions" value="513"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MLN6"/>
    <dbReference type="GeneID" id="8101827"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_101390"/>
    <dbReference type="eggNOG" id="KOG3244">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061241_0_0_1"/>
    <dbReference type="InParanoid" id="B8MLN6"/>
    <dbReference type="OMA" id="YYERHFH"/>
    <dbReference type="OrthoDB" id="4249at2759"/>
    <dbReference type="PhylomeDB" id="B8MLN6"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120539">
        <property type="term" value="F:4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03111">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007715">
        <property type="entry name" value="Coq4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027540">
        <property type="entry name" value="Coq4_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05019">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0831">Ubiquinone biosynthesis</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000388139" description="Ubiquinone biosynthesis protein coq4, mitochondrial">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03111"/>
        </source>
    </evidence>
    <sequence length="287" mass="32872" checksum="6D79291C7C20436B" modified="2009-03-03" version="1">MPPTPRTALLTVSNRCLQCHEIGLKYSFRSFSALNRPPPSYPGHVPLTRIERGVLAIGSAFGSLLNPRRHDLIAALGEATATPYFIYRLRDAMLSSPTGRRILRDRPRLTSETLKLPYLRSLPENSVGRTYAKWLDREGVSPDTRDSVQYIDDEECAYVMQRYRECHDFYHAVTGLPTMVEGELALKAFEFLNTVIPMTGLSLAAAIRLKPAERERFFKLHLPWAVRSGLSSEELINVYWEEQLERNVDELRAELGIEAPPDLREIRRMMRQQEKRAKEQQMKASGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLT7</accession>
    <name>B8MLT7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DSBA-like thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_100490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486042.1">
        <property type="nucleotide sequence ID" value="XM_002485997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLT7"/>
    <dbReference type="GeneID" id="8097933"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_100490"/>
    <dbReference type="eggNOG" id="ENOG502QTH7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069253_0_1_1"/>
    <dbReference type="InParanoid" id="B8MLT7"/>
    <dbReference type="OMA" id="QKYAISG"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="PhylomeDB" id="B8MLT7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03024">
        <property type="entry name" value="DsbA_FrnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF41">
        <property type="entry name" value="THIOREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="6"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="217" mass="24308" checksum="6292F6EEC40B9E86" modified="2009-03-03" version="1">MTNFNIEIVSDPVCPWCYIGKKKLDKAIEIYQPSHPDDTFTKTWKPFYVKPHSPEKDEKQYGTMMADMMTERVRSIGAEVGINFKFQGKTGRTRDAHRLIQLGKTKSPEMQTRVVEELFAAYWEGEADITSHEDLTKAGVKAGLDEVEVKEWLADDKGGQEVDAEARSAHVYGVPNYIVGKYTVGGAQDPGAFLKIFNKIKVIENGEPEGWGSCVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8MM64</accession>
    <name>B8MM64_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_098330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485814.1">
        <property type="nucleotide sequence ID" value="XM_002485769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MM64"/>
    <dbReference type="STRING" id="441959.B8MM64"/>
    <dbReference type="GeneID" id="8099661"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_098330"/>
    <dbReference type="HOGENOM" id="CLU_1983060_0_0_1"/>
    <dbReference type="InParanoid" id="B8MM64"/>
    <dbReference type="OrthoDB" id="4369552at2759"/>
    <dbReference type="PhylomeDB" id="B8MM64"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED13576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14410" checksum="FE33E52F3BF939C2" modified="2009-03-03" version="1">MEAHTLYHAASLALYVEILDLQIVAGATQILGRTFMHAAKEEFEALKKKGTFDFVLKPQNKQILTPTWVFKYKFDKYGKLTKFKARICVRGDLQQPNDLEKRAATLAAQNFRMMMAIAAIFNLKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MM87</accession>
    <name>B8MM87_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_098560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485837.1">
        <property type="nucleotide sequence ID" value="XM_002485792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MM87"/>
    <dbReference type="STRING" id="441959.B8MM87"/>
    <dbReference type="GeneID" id="8099684"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_098560"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_3_2_1"/>
    <dbReference type="InParanoid" id="B8MM87"/>
    <dbReference type="OMA" id="WGLTLNW"/>
    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="PhylomeDB" id="B8MM87"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF1">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="8"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED13599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="403" mass="45080" checksum="DE3B0241299E3499" modified="2009-03-03" version="1">MATETSSPILIVGAGISGLSLAQYLRKSGIPFRIFDRDASIVSRTGGWGLTFHWGLPALKELLPDELYERLRECNVNPNAQDAGKYRFLDLKTGESLHAATFPKTGRLRVIRSKLRTLLATGIDIEWSKKCVDISDNQDGVSISFEDGTTANGWLLVASDGANSRIRQCLHPSAFENNPVPVRLLGVTVSYTPEEVASALAIDPYFFQGTHSDSNIYLFFSFLNSPYNTGNDTGNYICQVIISWAESKSITTPESNQERIALIKRITSDWEPHLRSLIEIIPDDAEATTIHLADWFPTTNREHERVILMGDAAHTMTMFRGEGGNNATTDAYDFVKRIGPLIEEKNQHREVPWEKFKQALDEYDRDVLTRGRLCVINARQACLDAHDFSLVTEDSPLVSRRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>B8MM89</accession>
    <name>B8MM89_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_098580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485839.1">
        <property type="nucleotide sequence ID" value="XM_002485794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MM89"/>
    <dbReference type="GeneID" id="8099686"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_098580"/>
    <dbReference type="HOGENOM" id="CLU_2279357_0_0_1"/>
    <dbReference type="InParanoid" id="B8MM89"/>
    <dbReference type="OrthoDB" id="444432at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED13601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="102" mass="11635" checksum="D4F42DC1420BAAD4" modified="2009-03-03" version="1">MHKKESILLESTNSECIAGYYDYSTVHSITDSALVSRVAFNITDEEGEDTPVDLPMTCVLGRYDLNTDYNGLTDEQVENESKKLIMNGPIKAYLQWKFSYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNC9</accession>
    <name>B8MNC9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Elongation factor-1 beta,delta, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_102480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486256.1">
        <property type="nucleotide sequence ID" value="XM_002486211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNC9"/>
    <dbReference type="FunCoup" id="B8MNC9">
        <property type="interactions" value="796"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MNC9"/>
    <dbReference type="GeneID" id="8100825"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_102480"/>
    <dbReference type="eggNOG" id="KOG1668">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050172_0_2_1"/>
    <dbReference type="InParanoid" id="B8MNC9"/>
    <dbReference type="OMA" id="CHALCWY"/>
    <dbReference type="OrthoDB" id="331763at2759"/>
    <dbReference type="PhylomeDB" id="B8MNC9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005853">
        <property type="term" value="C:eukaryotic translation elongation factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000001">
        <property type="entry name" value="Elongation factor 1-beta 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053836">
        <property type="entry name" value="Arc1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018940">
        <property type="entry name" value="EF-1_beta_acid_region_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049720">
        <property type="entry name" value="EF1B_bsu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001326">
        <property type="entry name" value="Transl_elong_EF1B_B/D_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595">
        <property type="entry name" value="EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595:SF21">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21972">
        <property type="entry name" value="Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10587">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01182">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00825">
        <property type="entry name" value="EF1BD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elongation factor 1 beta central acidic region eukaryote" evidence="7">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="6">
        <location>
            <begin position="137"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED14018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="223" mass="24974" checksum="4F340C6BB12D2D9C" modified="2009-03-03" version="1">MRFSDLASDDGLRVLNTLLASRSYIVSFSPSQADVAVFKDITSHPDLSQYPHVARWYKHIDTYKSEFATLPGDPFKPYTTYGPEVDEASVTRDADDDDEDLYGREDEEEDQEAVCLQKERLAAYKAKKAIKPKPAAKSVVTLDVKPWDDETDMAALEALVRSIEKDGLVWGASKLVAVGFGIKKLQINLVVEDEKVSTVDLQEEIESFEDYVQSSDVVAMQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNL4</accession>
    <name>B8MNL4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_103270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486341.1">
        <property type="nucleotide sequence ID" value="XM_002486296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNL4"/>
    <dbReference type="GeneID" id="8103030"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_103270"/>
    <dbReference type="eggNOG" id="ENOG502S4MP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041458_0_1_1"/>
    <dbReference type="InParanoid" id="B8MNL4"/>
    <dbReference type="OMA" id="FLREGNC"/>
    <dbReference type="OrthoDB" id="3886346at2759"/>
    <dbReference type="PhylomeDB" id="B8MNL4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="381" mass="42938" checksum="A9094CBBF3E68BFC" modified="2009-03-03" version="1">MACFIQLRDNVPSWISEVNKLSAHVHTKRAEFAAEAENVIVSPSSLHRKKSISSSVTSVRSQRSVKHTGGHGLKRLLSRESLRSNEGVKKQRIMNNDESTKAEPTAPVPPSRRGKPTQVISYDGHTQKVLEAMVRDIWMAKSSIRSSRISASMRTAFGGRIKMQIPLKKSPETGIPDITSDTQANIEVDPDASTATDDDGLEDQLQLRMYMMKQRSRRSLAPPYTPRQQQPTRTKESPYDFIESQLENAQNLCETAAYKFLREGNCLDELDSILRAYELILEASTTMAEQEEERLKVEEEQEPSQEFTTMTTDELKRPAVAVTAATKELPDNDPEEMNAAILEVDDRSDTSEVSIDISAFRMTRTKIDILRITQRIGKVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPB2</accession>
    <name>B8MPB2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored serine-threonine rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_105620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486589.1">
        <property type="nucleotide sequence ID" value="XM_002486544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPB2"/>
    <dbReference type="STRING" id="441959.B8MPB2"/>
    <dbReference type="GeneID" id="8100421"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_105620"/>
    <dbReference type="eggNOG" id="ENOG502SFMK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096545_1_1_1"/>
    <dbReference type="InParanoid" id="B8MPB2"/>
    <dbReference type="OMA" id="AMCQSSC"/>
    <dbReference type="OrthoDB" id="5597238at2759"/>
    <dbReference type="PhylomeDB" id="B8MPB2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877618" description="GPI anchored serine-threonine rich protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED14351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="19844" checksum="3ABE7865DE13179F" modified="2009-03-03" version="1">MISVRPANELAKMKLSIVCLTVLAVLVASQDATSTTASLTSQQSCANKCDPIDICCSAACYQVPCPNNAMANDTTACAAACPQGSGTADDTAAYASCQQSCFSSLFFTGTATLPKATGSGTQFVADVSATATDRSHTILSGTVDSHAGNAPRTGSSQSSDSSATTTASGSSTIESGAASQIGVQLGVAGILGAVMAAFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQ14</accession>
    <name>B8MQ14_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF625 domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_054160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487015.1">
        <property type="nucleotide sequence ID" value="XM_002486970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQ14"/>
    <dbReference type="FunCoup" id="B8MQ14">
        <property type="interactions" value="903"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MQ14"/>
    <dbReference type="GeneID" id="8100355"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_054160"/>
    <dbReference type="eggNOG" id="KOG2175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004909_0_1_1"/>
    <dbReference type="InParanoid" id="B8MQ14"/>
    <dbReference type="OMA" id="ALMTHNN"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="PhylomeDB" id="B8MQ14"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055236">
        <property type="entry name" value="EVH1_PP4R3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22972">
        <property type="entry name" value="EVH1_PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PP4R3 EVH1-like" evidence="5">
        <location>
            <begin position="11"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central" evidence="4">
        <location>
            <begin position="141"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="705"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="859"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="728"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="751"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="764"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED12904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="883" mass="100042" checksum="BFB0408D7F08A32B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQ60</accession>
    <name>B8MQ60_TALSN</name>
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        <submittedName>
            <fullName evidence="4">DNA repair family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_055860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487197.1">
        <property type="nucleotide sequence ID" value="XM_002487152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQ60"/>
    <dbReference type="STRING" id="441959.B8MQ60"/>
    <dbReference type="GeneID" id="8102279"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_055860"/>
    <dbReference type="eggNOG" id="ENOG502R3Q4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048788_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQ60"/>
    <dbReference type="OMA" id="MCLRAMI"/>
    <dbReference type="OrthoDB" id="545910at2759"/>
    <dbReference type="PhylomeDB" id="B8MQ60"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035516">
        <property type="term" value="F:broad specificity oxidative DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051747">
        <property type="term" value="F:cytosine C-5 DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032852">
        <property type="entry name" value="ALKBH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573:SF1">
        <property type="entry name" value="DNA OXIDATIVE DEMETHYLASE ALKBH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="276"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR632852-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED13086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="414" mass="46519" checksum="ADFF3A30B8367DAB" modified="2009-03-03" version="1">MCLRAMIRVESKEIGKVHDKTLLIEAKISHKDLEVRARSWRQFPFSERMSKRTLDAYLKPVRSSTDTSSSKKLKETTATTAATRTSVVDATDIKENTAASKISRNETKPPDYTADTHPSYPVPITAIRPHIYTALKATTPARTPKAINNQPHLDLLYYEPFIPQPTADEYFQFLRRELPFYRVRYTIKRGPTETVINTPRYTTVFGVDTTSYFSLPPGERDSDCKDKGNPEGKLLFDSKTHQPISKNKYKCTPRPIPSCLDHLRKTVEATLNHGTSYNFVLVNYYASGDDSISYHSDDERFLGPLPNIASLTLGARRDFLMKHKAVAGAAPRKDKPLKLPLGSGDLIIMRGDTQSNWLHSIPKRKGGESGSGRINITLRKAVVPGGTENYYRYNVGDGGLYRWSDSAKEMVLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQ82</accession>
    <name>B8MQ82_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_056530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal RNase P protein component 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487263.1">
        <property type="nucleotide sequence ID" value="XM_002487218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQ82"/>
    <dbReference type="FunCoup" id="B8MQ82">
        <property type="interactions" value="256"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MQ82"/>
    <dbReference type="GeneID" id="8100716"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_056530"/>
    <dbReference type="eggNOG" id="KOG4639">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086710_1_1_1"/>
    <dbReference type="InParanoid" id="B8MQ82"/>
    <dbReference type="OMA" id="IVRCPRA"/>
    <dbReference type="OrthoDB" id="24745at2759"/>
    <dbReference type="PhylomeDB" id="B8MQ82"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030681">
        <property type="term" value="C:multimeric ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="entry name" value="Ribonuclease P, Pop5 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441:SF2">
        <property type="entry name" value="RIBONUCLEASE P_MRP PROTEIN SUBUNIT POP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="Rnp2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="182"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED13152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="212" mass="22865" checksum="4D43BBE2EFB1752C" modified="2009-03-03" version="1">MVRIKHRYLLIDILHPEPSQIHKLAASSSSSSSSSSSSVPAHLYFHPPTPDTLTSSVLARLLRETISDLFGDYGIGKLGGASSGNLIVKYLSPATSTAIIRCPRAAYRLVWAALTYLNAIPVPATTTATAKKSETTMRNAVFRVARVSGTMRKAEEEAIRRARREIARAKRDNVGVWGALFPGKDGGGGGDDEAVFGMDIDSDDDEDDDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQI6</accession>
    <name>B8MQI6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">COP9 signalosome complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_058760</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN4 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487499.1">
        <property type="nucleotide sequence ID" value="XM_002487454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQI6"/>
    <dbReference type="STRING" id="441959.B8MQI6"/>
    <dbReference type="GeneID" id="8106478"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_058760"/>
    <dbReference type="eggNOG" id="KOG1497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028132_1_1_1"/>
    <dbReference type="InParanoid" id="B8MQI6"/>
    <dbReference type="OMA" id="KNIMHTV"/>
    <dbReference type="OrthoDB" id="295656at2759"/>
    <dbReference type="PhylomeDB" id="B8MQI6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000190">
        <property type="entry name" value="COP9 signalosome complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="194"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED13388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="421" mass="46337" checksum="625E49146787C29B" modified="2009-03-03" version="1">MASQKVASALAEIESSPSQATKSQLYNDLLGKIVSTSTGHELSQDLIYYLDSILSENVSVVAARPLLDSFINVLRDLSPAIKIKVGQHAVTLLQSRSASVEEQDSNIREILADAYEVEEEYSAAARVLQGIHLDSSQRLITDAAKTRMWIRILRLYLEEDDTTNAESFLNRIKNLPSKIEDPELKLHFQLSQARILDARRRFLDASQEYFNVSLASGVDESDRLHALSAAIICAVLAPAGPQRSRTLARLYKDDRATSVDVFAILEKMHLDRLLTPDEVTAFSQKLQPHQLAKTADGSTVLDKAVIEHNLVAASRLYENIKTDALGAILALKDSSDETAGEKAEAYAARMVEQGRLKGSIDQIDGIIYFDSDISGVENTGTMGRNIRLWDAGIESVTEDVERVAANVADAFPELAISQMVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQK6</accession>
    <name>B8MQK6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_058950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487519.1">
        <property type="nucleotide sequence ID" value="XM_002487474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQK6"/>
    <dbReference type="FunCoup" id="B8MQK6">
        <property type="interactions" value="1037"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MQK6"/>
    <dbReference type="GeneID" id="8106497"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_058950"/>
    <dbReference type="eggNOG" id="KOG3298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085878_2_0_1"/>
    <dbReference type="InParanoid" id="B8MQK6"/>
    <dbReference type="OMA" id="TMRQPGL"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="PhylomeDB" id="B8MQK6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990328">
        <property type="term" value="C:RPB4-RPB7 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010590">
        <property type="term" value="P:regulation of septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000156">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="7">
        <location>
            <begin position="9"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="77"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED13408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="169" mass="18791" checksum="B998CA173BD47769" modified="2009-03-03" version="1">MFFLKEETKVVTLHPSFFGPNVKEYLVNRLNEEEEGRCTGDHFVICVMDMVDIGEGRVIPGSGHAEYTIKYRAIIWKPFRGETVDAIVTSVKPTGIFTLAGPLSVFIARKNIPSDIKWEPGTVPPQYTDHADQVIERGTSLRLKILGVKPDVSAINAIGTIKEDYLGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQZ1</accession>
    <name>B8MQZ1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_053440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486937.1">
        <property type="nucleotide sequence ID" value="XM_002486892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQZ1"/>
    <dbReference type="GeneID" id="8098295"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_053440"/>
    <dbReference type="eggNOG" id="ENOG502SP4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123432_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQZ1"/>
    <dbReference type="OMA" id="VANSFVM"/>
    <dbReference type="OrthoDB" id="202672at2759"/>
    <dbReference type="PhylomeDB" id="B8MQZ1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024512">
        <property type="entry name" value="Ser_palmitoyltrfase_ssu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11779">
        <property type="entry name" value="SPT_ssu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED12826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="135" mass="15401" checksum="39319D970B26B170" modified="2009-03-03" version="1">MATEVRSFYTPSTTAHVSQPIVDELMMSHGRTRNLVQRCIDHIRLQYYRYEVTFGVYVMTPGEKFVANTFVLVFLSLLIWASLLYFPQLLFRKIGRLVWLLTGHSEDVAALFGIFEHVYISPATSATMPTSSMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8MR05</accession>
    <name>B8MR05_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_053580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTI2 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486951.1">
        <property type="nucleotide sequence ID" value="XM_002486906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MR05"/>
    <dbReference type="STRING" id="441959.B8MR05"/>
    <dbReference type="GeneID" id="8098309"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_053580"/>
    <dbReference type="eggNOG" id="ENOG502S3SJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024466_1_0_1"/>
    <dbReference type="InParanoid" id="B8MR05"/>
    <dbReference type="OrthoDB" id="6417021at2759"/>
    <dbReference type="PhylomeDB" id="B8MR05"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110078">
        <property type="term" value="C:TTT Hsp90 cochaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018870">
        <property type="entry name" value="Tti2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32226">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32226:SF2">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10521">
        <property type="entry name" value="Tti2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="603" mass="67520" checksum="2E3359E300B3383D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MR58</accession>
    <name>B8MR58_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">xyloglucan-specific endo-beta-1,4-glucanase</fullName>
            <ecNumber evidence="3">3.2.1.151</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Xyloglucanase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Xyloglucanendohydrolase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_054630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>xyloglucan + H2O = xyloglucan oligosaccharides.</text>
            <dbReference type="EC" id="3.2.1.151"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.151" evidence="3"/>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487064.1">
        <property type="nucleotide sequence ID" value="XM_002487019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MR58"/>
    <dbReference type="STRING" id="441959.B8MR58"/>
    <dbReference type="GeneID" id="8100401"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_054630"/>
    <dbReference type="eggNOG" id="ENOG502S675">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1533581_0_0_1"/>
    <dbReference type="InParanoid" id="B8MR58"/>
    <dbReference type="OrthoDB" id="95118at2759"/>
    <dbReference type="PhylomeDB" id="B8MR58"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033946">
        <property type="term" value="F:xyloglucan-specific endo-beta-1,4-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF9">
        <property type="entry name" value="XYLOGLUCAN-SPECIFIC ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED12953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="175" mass="19589" checksum="504680FE29D2F53F" modified="2009-03-03" version="1">MYRDRVPYQRHTHMVHYLVMGRYLMRCQEFRKRCIYYYSKAVDYTGSNIVADVAYNLFTSYSASGSAQYEIMIWLAALGGANPISSSGSTIATPTIGGITWNLYSRPNGATTVYGFAASSEQSSYSGNLLDFFKYLEDYEGFSSSQYLLSVQAGTEPFTGPNAELYSTYCYCGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRS6</accession>
    <name>B8MRS6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bromodomain associated domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_057500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487371.1">
        <property type="nucleotide sequence ID" value="XM_002487326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRS6"/>
    <dbReference type="STRING" id="441959.B8MRS6"/>
    <dbReference type="GeneID" id="8108886"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_057500"/>
    <dbReference type="eggNOG" id="ENOG502S96D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064111_0_0_1"/>
    <dbReference type="InParanoid" id="B8MRS6"/>
    <dbReference type="OMA" id="EWEEDWQ"/>
    <dbReference type="OrthoDB" id="5402929at2759"/>
    <dbReference type="PhylomeDB" id="B8MRS6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00576">
        <property type="entry name" value="BTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="5">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED13260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="230" mass="25665" checksum="3EA81F7C2A5BF402" modified="2009-03-03" version="1">MSGPHTLHNALLRPPIIQILRAAGYHSSRPSVIDTLADLTIRYLLLLGSSAAEHAANSHPDDPVPTLQDIQLALQDVGALRPQMKDFEEDWRGEEDLRGLESFISWFSGPVNREIRRIAGYIPTEGDVVDADMLEKEDYLTALKKKHSKTGEESRYAGTVLGRDAEEHPIIIEGGSAMSIGEWASQIKTREPFDESELKRTQRLALLTTTSAPQLRRTYRLDGIHTLDMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MS91</accession>
    <name>B8MS91_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arsenate reductase (ArsC), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_002880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487878.1">
        <property type="nucleotide sequence ID" value="XM_002487833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MS91"/>
    <dbReference type="STRING" id="441959.B8MS91"/>
    <dbReference type="GeneID" id="8102899"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_002880"/>
    <dbReference type="eggNOG" id="ENOG502S4HS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071415_3_3_1"/>
    <dbReference type="InParanoid" id="B8MS91"/>
    <dbReference type="OMA" id="VTMGCNV"/>
    <dbReference type="OrthoDB" id="2011805at2759"/>
    <dbReference type="PhylomeDB" id="B8MS91"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046685">
        <property type="term" value="P:response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16345">
        <property type="entry name" value="LMWP_ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43428">
        <property type="entry name" value="ARSENATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43428:SF1">
        <property type="entry name" value="ARSENATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="Phosphotyrosine protein phosphatases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0059">Arsenical resistance</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphotyrosine protein phosphatase I" evidence="2">
        <location>
            <begin position="5"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED12224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="135" mass="14632" checksum="3A5C402A64E0AAED" modified="2009-03-03" version="1">MATKPSALFVCIHNAGRSQMAAAYLSHLAGNAIEVRSAGSAPANTINPMVVGAMREEGIDIIDQKPKILTSESVEASDVVITMGCGDVCPFFPGKRYLDWKLDDPAGQGIEAIRLIRDEIRCRVENLIQEMLQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSC4</accession>
    <name>B8MSC4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_003680</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487965.1">
        <property type="nucleotide sequence ID" value="XM_002487920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSC4"/>
    <dbReference type="FunCoup" id="B8MSC4">
        <property type="interactions" value="1070"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MSC4"/>
    <dbReference type="GeneID" id="8098064"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_003680"/>
    <dbReference type="eggNOG" id="KOG0729">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_6_2_1"/>
    <dbReference type="InParanoid" id="B8MSC4"/>
    <dbReference type="OMA" id="RSKYHIE"/>
    <dbReference type="OrthoDB" id="1937997at2759"/>
    <dbReference type="PhylomeDB" id="B8MSC4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045899">
        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000005">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048723">
        <property type="entry name" value="OB_PRS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21236">
        <property type="entry name" value="OB_PRS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="214"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED12311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="439" mass="49038" checksum="DBB74EBE7F5CC569" modified="2009-03-03" version="1">MPSATGSDWEKYKKNFADDEIPEKKITPLTDEDIQVLKTYGAAPYAAALKKLEKQIKEKQQSVNEKIGVKESDTGLAPPHLWDVAADRQRMAEEQPLQVARCTKIIQDEKDPEKSKYVINVKQIAKFVVNLGERVSPTDIEEGMRVGVDRNKYQILLPLPPKIDPSVTMMQVEDKPDVTYGDVGGSKEQIEKLREVVEMPLLSPERFVNLGIDPPKGALLYGPPGTGKTLCARAVANRTDATFIRVIGSELVQKYVGEGARMVRELFEMARTKKACIIFFDEIDAIGGARFDDGAGGDNEVQRTMLELITQLDGFDSRGNIKVMFATNRPSTLDPALMRPGRIDRKIEFSLPDMEGRANILRIHAKSMSVERDIRWELISRLCPNATGAELRSVATEAGMYAIRARRKVATEKDFLAAVDKVIKGNLKFNSTATYMQYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSC7</accession>
    <name>B8MSC7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_003710</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487968.1">
        <property type="nucleotide sequence ID" value="XM_002487923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSC7"/>
    <dbReference type="FunCoup" id="B8MSC7">
        <property type="interactions" value="636"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MSC7"/>
    <dbReference type="GeneID" id="8098067"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_003710"/>
    <dbReference type="eggNOG" id="KOG0989">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042324_1_0_1"/>
    <dbReference type="InParanoid" id="B8MSC7"/>
    <dbReference type="OMA" id="GCQSGSF"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="PhylomeDB" id="B8MSC7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
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        <property type="entry name" value="AAA"/>
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        <property type="entry name" value="RCF1-5-like_lid"/>
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        <property type="entry name" value="Rep_fac_C"/>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="71"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="17"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED12314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="393" mass="42995" checksum="BE7E825876A73C0E" modified="2009-03-03" version="1">MASNFFNNKARAAAAAAAAASGSSKQKTSENAEEQARLQPWVEKYRPKSLDDVAAQDHTTAVLQRTLQASNLPHMLFYGPPGTGKTSTILALSKSLFGPALYRTRILELNASDERGINIVREKIKDFARTQLSHPSGLDAAYKAKYPCPPFKIIILDEADSMTQDAQSALRRTMEQYSRITRFCLVCNYVTRIIEPLASRCSKFRFKALDGVSAGDRINEIAQAEGLTLDDGVVDTLIRCSEGDLRRAITYLQSAARLVGATSTQKGKKDQEDTEMTDAGSSLITVQTVEEIAGVVPESVLDKLTQAMQPKKMGSAYEAVASVVSDIVADGWSATQILTQLYRRTVFNDAIPDTQKNKIVMVFSEMDKRLLDGSDEHLSILDMVLKISGILGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MT09</accession>
    <name>B8MT09_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Efflux pump antibiotic resistance protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_001050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EED12033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002487642.1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_001050"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_5_1"/>
    <dbReference type="InParanoid" id="B8MT09"/>
    <dbReference type="OMA" id="TIYMAIC"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="PhylomeDB" id="B8MT09"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF48">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
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    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="98"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED12033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="550" mass="61023" checksum="23C71C69539EF20F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8MU62</accession>
    <name>B8MU62_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_109600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488536.1">
        <property type="nucleotide sequence ID" value="XM_002488491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MU62"/>
    <dbReference type="GeneID" id="8107192"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109600"/>
    <dbReference type="HOGENOM" id="CLU_1807519_0_0_1"/>
    <dbReference type="InParanoid" id="B8MU62"/>
    <dbReference type="OMA" id="PHISEGK"/>
    <dbReference type="OrthoDB" id="5077812at2759"/>
    <dbReference type="PhylomeDB" id="B8MU62"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="143" mass="15780" checksum="CBCDF41A354D79B3" modified="2009-03-03" version="1">MAKQVVAMPNKEVFDAEAEAALTRLKATMHSTAQHAPNLWICLDNLEVTIQLLSSPTGSSQTVFKSFNTLAATWPSRRRLLQIEGGAVRIRWVPGHANIPRNKAADCATKEGTEKTIPTSHPWSYAALKRHTRSQAASRAQTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUD6</accession>
    <name>B8MUD6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_108280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488396.1">
        <property type="nucleotide sequence ID" value="XM_002488351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUD6"/>
    <dbReference type="GeneID" id="8106892"/>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054208">
        <property type="entry name" value="DUF6914"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21858">
        <property type="entry name" value="DUF6914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="179" mass="20498" checksum="EEFC30CC99080D3A" modified="2009-03-03" version="1">MPSNKDRLYVGLYARGGNPTMPGKEDTYHWALIVGPKVEAEDGIGVRYHAKERPKLGGGSEWFFEERECPLAPTSMLLVRIVIGKIEDGNRLVQILRNTPIRQGQPGWNCVGWVKEALEKLRVDPKALGTSIVEWEKVRGEAMNYCQRKKDQHRFDGQGNFDMRKVPTYDLMERKEIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUE8</accession>
    <name>B8MUE8_TALSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_109670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488543.1">
        <property type="nucleotide sequence ID" value="XM_002488498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUE8"/>
    <dbReference type="GeneID" id="8107199"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109670"/>
    <dbReference type="HOGENOM" id="CLU_977205_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUE8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="152"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="285" mass="30304" checksum="4F9559003F352F20" modified="2009-03-03" version="1">MSNSCSLGGISLQANCPTLTDWRLRDLGNNCSAQLFYADLNRTYSLGTFFYPETESCEKFGQIIFLDDVPTGPGDLDVVCNGQQQARDQCYTVTVNNSPCMGTSSGTSSNSNYIEPVCLDRSPTIQPTASSPGPPISFTATPTITNTEIFPTSTIASNTSPTPPTVPSDTSPTPPIVPSDVSTTTLTPFSPPSFISPTAADSSPPPTIPSDVSTTILNPPSTVTVTVTAISQPTTFTTIFAPSSEPTTTLPYSSACNFFLHNQRDNNYSLPSLQSHQKSPSQLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUI4</accession>
    <name>B8MUI4_TALSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_108390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488408.1">
        <property type="nucleotide sequence ID" value="XM_002488363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUI4"/>
    <dbReference type="GeneID" id="8106903"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_108390"/>
    <dbReference type="eggNOG" id="ENOG502T5HK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031994_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUI4"/>
    <dbReference type="OrthoDB" id="5460188at2759"/>
    <dbReference type="PhylomeDB" id="B8MUI4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="458" mass="51024" checksum="E8FDCF26382A12A6" modified="2009-03-03" version="1">MADSSNPDTTSSNVRGIAAISPPISIETANCSTPETYKVATRANMQASIEDVSDEGDDIIQQSGRASPTGYDENMQPNYVNDEGENIVPQKKRVRLSGDGENMQASVEDVSGEGSGILPQKKRVRPTGDGGRLRQPGPRKKPPLKKSSEAKHARSTAQKISNQQADASRSVTRYSAYDQMRCLFGSGKAEKEKLSESSFIRVLALYAKSSRPDLATFLENLSNLWRANRFWSPDALHLSMPEELPSGSSCLRLFRYDRDLGKESGINVIRRRFVQLKLHLSFIRLCNEMTNPKSPCFKTGLNSRRIPSHAIDNLMELEGSNGYSDDPLAPKDRGRFVKTNAKGRRWYLISHYIGWGSLIIFNNIDTTLAKVDLIELEAFIIYVLNTQPRVVALCHKYEQPVKDLLNGRKPALTLTEQEVTSTIGGLPHAIDHNEGAKNHWQRINTKIDTDVSEVLSHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUL6</accession>
    <name>B8MUL6_TALSN</name>
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        <submittedName>
            <fullName evidence="3">Reverse transcriptase [C. elegans], putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_108700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488440.1">
        <property type="nucleotide sequence ID" value="XM_002488395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUL6"/>
    <dbReference type="STRING" id="441959.B8MUL6"/>
    <dbReference type="GeneID" id="8103126"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_108700"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_23_3_1"/>
    <dbReference type="InParanoid" id="B8MUL6"/>
    <dbReference type="OMA" id="MNIRTPE"/>
    <dbReference type="OrthoDB" id="4464205at2759"/>
    <dbReference type="PhylomeDB" id="B8MUL6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="349"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="799"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED11684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1129" mass="128410" checksum="FCAC8F207A3E55F0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUM2</accession>
    <name>B8MUM2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_108760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488446.1">
        <property type="nucleotide sequence ID" value="XM_002488401.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488447.1">
        <property type="nucleotide sequence ID" value="XM_002488402.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488448.1">
        <property type="nucleotide sequence ID" value="XM_002488403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUM2"/>
    <dbReference type="GeneID" id="8103132"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_108760"/>
    <dbReference type="eggNOG" id="ENOG502RPQB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1876826_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUM2"/>
    <dbReference type="OMA" id="DTSACNE"/>
    <dbReference type="OrthoDB" id="4194786at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="136" mass="14934" checksum="8BE3D355AD1995B7" modified="2009-03-03" version="1">MSVVDVVSPRVIEQGQKAWSTVKEQCEKINKPATGQSIGHCTPTHDCKLAMDYAIEDAAMNDTVAKSTQRLLALLIYFPKGAVIGDSPTLVIPIHIEGTAKIGQINIDTNHYYEVRSRTILEVPEESKVSAIVLSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUS0</accession>
    <name>B8MUS0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_109880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488564.1">
        <property type="nucleotide sequence ID" value="XM_002488519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUS0"/>
    <dbReference type="STRING" id="441959.B8MUS0"/>
    <dbReference type="GeneID" id="8107220"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109880"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_4_1"/>
    <dbReference type="InParanoid" id="B8MUS0"/>
    <dbReference type="OMA" id="SRMDETH"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="PhylomeDB" id="B8MUS0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="82"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED11808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="522" mass="57504" checksum="ADD79603DF4B1D43" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUY5</accession>
    <name>B8MUY5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_110060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488582.1">
        <property type="nucleotide sequence ID" value="XM_002488537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUY5"/>
    <dbReference type="STRING" id="441959.B8MUY5"/>
    <dbReference type="GeneID" id="8107238"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_110060"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_11_2_1"/>
    <dbReference type="InParanoid" id="B8MUY5"/>
    <dbReference type="OMA" id="NCKKASH"/>
    <dbReference type="OrthoDB" id="4526357at2759"/>
    <dbReference type="PhylomeDB" id="B8MUY5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="477"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED11826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="864" mass="94920" checksum="C4C3D8119EC91190" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MVF6</accession>
    <name>B8MVF6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinesin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_007550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962663">
        <property type="protein sequence ID" value="EED11465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488781.1">
        <property type="nucleotide sequence ID" value="XM_002488736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MVF6"/>
    <dbReference type="STRING" id="441959.B8MVF6"/>
    <dbReference type="GeneID" id="8103284"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_007550"/>
    <dbReference type="eggNOG" id="KOG1840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_841992_0_0_1"/>
    <dbReference type="InParanoid" id="B8MVF6"/>
    <dbReference type="OMA" id="TSASFHM"/>
    <dbReference type="OrthoDB" id="4223291at2759"/>
    <dbReference type="PhylomeDB" id="B8MVF6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056681">
        <property type="entry name" value="DUF7779"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25000">
        <property type="entry name" value="DUF7779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7779" evidence="1">
        <location>
            <begin position="121"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="357" mass="40859" checksum="69F0317EB288604D" modified="2009-03-03" version="1">MTFKKSKPLRIELSSLRSQSSGDGFNRSLSEAYPVLLKRPSGSVLKDMVRECIPLAIAQAGAYISNRSPRMTVSSYLELFQQSETNQEHLLNYDEAHDLRRDQSGRYPVIMTWQISFDQIHHIYPKATDLLALMSMFDRQGIPEELVSEGIDQLQFEDTMALLISFSLIQVEIGGRLFELHRLVQLSVQQWLKKQGWLYQLVKQSLRVMEAVFPSGDYQTSASFHMLLPHFKEMIYFTKKLDDNDQLNMASIASRCGWHLYLMGKYEEAEAIHRRAVTIHEKVLGAEHPDTLVSVSHLGSVLQSQGQYEEAEVMHRRAFASREKVLGTEHPDTLASISHLNSVLYRQGKCEEAKAMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MVG9</accession>
    <name>B8MVG9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pogo transposable element, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_007680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962663">
        <property type="protein sequence ID" value="EED11478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488794.1">
        <property type="nucleotide sequence ID" value="XM_002488749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MVG9"/>
    <dbReference type="STRING" id="441959.B8MVG9"/>
    <dbReference type="GeneID" id="8103297"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_007680"/>
    <dbReference type="eggNOG" id="KOG3105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_6_2_1"/>
    <dbReference type="InParanoid" id="B8MVG9"/>
    <dbReference type="OMA" id="WTNSETG"/>
    <dbReference type="OrthoDB" id="4225981at2759"/>
    <dbReference type="PhylomeDB" id="B8MVG9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="49"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="3">
        <location>
            <begin position="457"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="464"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="490"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED11478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="534" mass="61996" checksum="AB7B08A6CA8630A9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8LSX1</accession>
    <name>B8LSX1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ASTRA-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_064360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the ASTRA complex involved in chromatin remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the ASTRA chromatin remodeling machinery complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ASA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340354.1">
        <property type="nucleotide sequence ID" value="XM_002340313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LSX1"/>
    <dbReference type="STRING" id="441959.B8LSX1"/>
    <dbReference type="GeneID" id="8104201"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_064360"/>
    <dbReference type="eggNOG" id="KOG0322">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041940_0_1_1"/>
    <dbReference type="InParanoid" id="B8LSX1"/>
    <dbReference type="OMA" id="WHKEGVY"/>
    <dbReference type="OrthoDB" id="7668193at2759"/>
    <dbReference type="PhylomeDB" id="B8LSX1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="20"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="431"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED22967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="446" mass="49383" checksum="1F8CF1DFF9603C3B" modified="2009-03-03" version="1">MTSITIQQQNLPPATPRYILRGHVSAIQALDFFASNTRLISADADGWVIIWDVVTKRARAVWKAHEGAVLEVKGYETAGQGMRIYTHSRDHKLRVWKIQFAGEEEQLSRVLPVEKSSKDGEQAPAPEPWLLHSLPVNALNFCAFTLCFIPYSNNEKLDGGNDDDPWRNATESLDIAEDEGYFAVPNALNSGAIDIFHLPSERRVSTIPADTSVQTGMVMAVKILIDNSNTQNALVYMLSGYEDGHVMVHISYPPSGSSTAWKWDKIYASQPHSQPILSLDSVQAETEHIPSFFYTSSADALIVKHPIPSMSSPPISSANTSVKNTPLKVLNTKHSGQQGLHVRGDQKLFATAGWDARIRVYSCKTMKELAVLKWHSEGCYAVAFADILPSTSADSPSTHKDDDSSIVRSQTSPLEIVRQQRNEKAQQTHWLAAGSKDGKISLWDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8LT16</accession>
    <name>B8LT16_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Epoxide hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_069440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340911.1">
        <property type="nucleotide sequence ID" value="XM_002340870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LT16"/>
    <dbReference type="STRING" id="441959.B8LT16"/>
    <dbReference type="GeneID" id="8106020"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_069440"/>
    <dbReference type="eggNOG" id="KOG2565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019414_0_0_1"/>
    <dbReference type="InParanoid" id="B8LT16"/>
    <dbReference type="OMA" id="VGVHVNY"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="PhylomeDB" id="B8LT16"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF39">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="4">
        <location>
            <begin position="53"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED23524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="449" mass="50856" checksum="49AC73532E448005" modified="2009-03-03" version="1">MKALFSLTTTSASQTRIRYLPEMTSPFLQILDSAESDREFGHPPPTIRVKQQACKIDIPPTEITDLQNLVSKARLGPVTFENSQPEVTKEFGLTRSWMSKAIQAWSSESTFNWNKIQDNINSIPQFISTVNHNNHSYSIHYMALWSLRADATPLVCIHGWPGCFIEYLAVAKLLQSKYTPDTLPYHFIVPSLPGYTFSSGPPADSNGDFSTYDVSCIFRSLFIDQLGFDQKGYIVAGGDIGSRVCRALAVDDEHCKGIHLTFCFDFDMRNFPRQGLKDNELRDIEAIETFVTAGAAYAQMHATRSATIGFVLSSNPVALLAWIAEKFLEWTDLTPDMETILTFMTLYWVTDTFSRSIYPYRHDFVPSEDVPCHGDGARWLIPRSKVFGFSHFPKEILPVPKAWVERTAVAEEVTFWREHEQGGHFAGVEVPGDLLEDLQEFVEHVRTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8LT50</accession>
    <name>B8LT50_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_069760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340945.1">
        <property type="nucleotide sequence ID" value="XM_002340904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LT50"/>
    <dbReference type="STRING" id="441959.B8LT50"/>
    <dbReference type="GeneID" id="8104729"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_069760"/>
    <dbReference type="eggNOG" id="ENOG502RXR0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040908_9_0_1"/>
    <dbReference type="InParanoid" id="B8LT50"/>
    <dbReference type="OMA" id="GWWYDWT"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="PhylomeDB" id="B8LT50"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF14">
        <property type="entry name" value="ASL1-LIKE GLYCOSYL HYDROLASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002874461" description="Asl1-like glycosyl hydrolase catalytic domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="3">
        <location>
            <begin position="137"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED23558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="367" mass="39987" checksum="91B7779AF7ED421B" modified="2009-03-03" version="1">MKPQSLAAGLMLAGLQMVSADHHHGALHFRHEQKPAVQEYDTTTTTTTSVLKVVTITTTITVSPDTAPTIVLAPIAEPTSSSLPTASIDSNTEAVASIANTQSSSTTSPSQGSKTNPLTPNGIKAGSAGGDAYPFWKDHIGWWYDWTPNPLKSYPDNTGHAIPISMLWGAGTVSHGDAVRYAEFQKLTAAPPYILGYEEPDCSPPDSSSISVQKGMKVWNEVVAPWGKKGSLLGSPSVCKQSDEDWLTPFQKGISTPWDFTAVHINTNNMGVVKKVLNHYWTKYNQKPIWVTEFACVDTSNGFKASENQTQINKFIADIVDLFQRDDRVYAYAYSAGRGLGSTWPPVKDEKLTESGRVYLDAIRKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUA3</accession>
    <name>B8LUA3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_060670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002339962.1">
        <property type="nucleotide sequence ID" value="XM_002339921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUA3"/>
    <dbReference type="STRING" id="441959.B8LUA3"/>
    <dbReference type="GeneID" id="8101270"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_060670"/>
    <dbReference type="HOGENOM" id="CLU_1074326_0_0_1"/>
    <dbReference type="InParanoid" id="B8LUA3"/>
    <dbReference type="OrthoDB" id="5064334at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="259" mass="29659" checksum="22B01B20CFF06E45" modified="2009-03-03" version="1">MDTADRASWLAQIQRDRAKRLELDKTEVDLRRRRTHLDLQDDDDNQEENREPPPEVKPLIDMFPGVSAALLTRIFERKLKATKLLHFKEKSVIDADQENGVFKMTESGGTVSFKKAASSLKDWGPNPQTWTSCFLTYLAVIGYLFGDKHPKAVPNLLMFMRQILDFAQTYQWPEAVLPLALNFHQYLLDKGELSTDSYLVTPQFREKYLRYNLTLPAKPTQNPSAARPRHAKSARSLNNDTEILCGLGKHGAITCRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUL5</accession>
    <name>B8LUL5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 74</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_072620</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Mediates the cis and medial Golgi localization of mannosyltransferases through direct binding of their cytosolic domains. Involved in vacuolar protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">Golgi stack membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLPH3/VPS74 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341259.1">
        <property type="nucleotide sequence ID" value="XM_002341218.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341260.1">
        <property type="nucleotide sequence ID" value="XM_002341219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUL5"/>
    <dbReference type="FunCoup" id="B8LUL5">
        <property type="interactions" value="542"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LUL5"/>
    <dbReference type="GeneID" id="8104263"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_072620"/>
    <dbReference type="eggNOG" id="KOG3983">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036311_1_0_1"/>
    <dbReference type="InParanoid" id="B8LUL5"/>
    <dbReference type="OMA" id="GETWNLL"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048194">
        <property type="term" value="P:Golgi vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060304">
        <property type="term" value="P:regulation of phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3630.10:FF:000002">
        <property type="entry name" value="Vacuolar sorting-associated 74 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="entry name" value="yeast vps74-n-term truncation variant domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704:SF2">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 3 HOMOLOG SAURON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="TRANS-GOLGI PROTEIN GMX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED23872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="352" mass="39619" checksum="5A1A0E17FC72A747" modified="2009-03-03" version="1">MASAGGLTRRRGGRVGGEDNEEGSRVSSPVPNNRTAVDARTPETSYTDGENGHKIAFDPRDISENEERTRMPKLTLMDEVVLLGLKDKQGYLSFWNENISYALRGCIVIELAFRGRISMQKDPARRRFPLADRVIEVIDDTLTGEVLLDEALKMMKSSEKMSVSTWIDLMSGETWNLMKIGYQLKQVRERIMKGLVDKGVLRTEKRNFLLFDMATHPVADSGAKEELHKRVRNVCSSRTVILTPNQWLPEDVEFRFLRTISMVCAAYAANVLENALVTMSHESRERAFAQVDELLAEYSQWPFARKSGAGQSIGANLAQAVNDEINKSKDRELQLEIVAACLSVFTRLDSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUU2</accession>
    <name>B8LUU2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF1339 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_074160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341421.1">
        <property type="nucleotide sequence ID" value="XM_002341380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUU2"/>
    <dbReference type="STRING" id="441959.B8LUU2"/>
    <dbReference type="GeneID" id="8109480"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_074160"/>
    <dbReference type="eggNOG" id="KOG2006">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002060_1_1_1"/>
    <dbReference type="InParanoid" id="B8LUU2"/>
    <dbReference type="OMA" id="MVYDRAM"/>
    <dbReference type="OrthoDB" id="67540at2759"/>
    <dbReference type="PhylomeDB" id="B8LUU2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034066">
        <property type="term" value="C:Ric1-Rgp1 guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040096">
        <property type="entry name" value="Ric1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009771">
        <property type="entry name" value="RIC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746:SF10">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR SUBUNIT RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746">
        <property type="entry name" value="RAB6A-GEF COMPLEX PARTNER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25440">
        <property type="entry name" value="Beta-prop_RIC1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07064">
        <property type="entry name" value="RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIC1 C-terminal alpha solenoid region" evidence="4">
        <location>
            <begin position="807"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1023"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1044"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1071"/>
            <end position="1080"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED24034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1086" mass="120091" checksum="1C280A87BC6195A2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8LV44</accession>
    <name>B8LV44_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450 monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_065490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340481.1">
        <property type="nucleotide sequence ID" value="XM_002340440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LV44"/>
    <dbReference type="FunCoup" id="B8LV44">
        <property type="interactions" value="1478"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LV44"/>
    <dbReference type="GeneID" id="8102698"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_065490"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_5_11_1"/>
    <dbReference type="InParanoid" id="B8LV44"/>
    <dbReference type="OMA" id="MKHYGEV"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="PhylomeDB" id="B8LV44"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000051">
        <property type="entry name" value="Cytochrome P450 monooxygenase (Fum15)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF227">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="513"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED23094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="567" mass="64542" checksum="CBB19E6F7D7851CA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVE7</accession>
    <name>B8LVE7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_073550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the VPS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341353.1">
        <property type="nucleotide sequence ID" value="XM_002341312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVE7"/>
    <dbReference type="FunCoup" id="B8LVE7">
        <property type="interactions" value="1055"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LVE7"/>
    <dbReference type="GeneID" id="8106050"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_073550"/>
    <dbReference type="eggNOG" id="KOG3325">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063749_0_1_1"/>
    <dbReference type="InParanoid" id="B8LVE7"/>
    <dbReference type="OMA" id="VRGNMDY"/>
    <dbReference type="OrthoDB" id="10258130at2759"/>
    <dbReference type="PhylomeDB" id="B8LVE7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
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        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
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        <property type="entry name" value="Metallo-depent_PP-like"/>
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        <property type="entry name" value="yfcE"/>
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        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
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    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="7"/>
            <end position="164"/>
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        <source>
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        <source>
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        <source>
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        <source>
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            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED23966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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        </source>
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    <sequence length="200" mass="21840" checksum="4900ACD783F56043" modified="2009-03-03" version="1">MTSRLVLVIGDLFIPDRAPDIPARFKKLLTPGKIGQILCLGNLTDRDTFEFFRQIAPDLQLVKGDFDVDSPNLPLSKVVTHGSLRIGFTHGHTIIPPGDADALLIAARQMDVDVLLWGGTHRFEAFEMEGRFFINPGSATGAFSTGYFPDGQEPIPSFCLMDVQGDVLVLYVYQLKTDANGAETVAVEKVSFRKQGVAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWH2</accession>
    <name>B8LWH2_TALSN</name>
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        <submittedName>
            <fullName evidence="3">DNA repair protein Rtt107, putative</fullName>
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        <name evidence="3" type="ORF">TSTA_076510</name>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED24283.1"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="4"/>
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        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="342"/>
            <end position="425"/>
        </location>
    </feature>
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        <location>
            <begin position="647"/>
            <end position="711"/>
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    </feature>
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        <location>
            <begin position="478"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="488"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED24283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="860" mass="96104" checksum="DFF12BB6FEFB6C37" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8LX36</accession>
    <name>B8LX36_TALSN</name>
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        <submittedName>
            <fullName evidence="9">Bicyclomycin resistance protein, putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="ORF">TSTA_061740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EED22686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002340032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LX36"/>
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        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LX36"/>
    <dbReference type="GeneID" id="8106011"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_061740"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_8_5_1"/>
    <dbReference type="InParanoid" id="B8LX36"/>
    <dbReference type="OMA" id="LWWSHLA"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="PhylomeDB" id="B8LX36"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015203">
        <property type="term" value="F:polyamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010509">
        <property type="term" value="P:intracellular polyamine homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000172">
        <property type="entry name" value="MFS multidrug resistance transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF5">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
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    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="98"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED22686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="541" mass="59880" checksum="3ECECA1528CDF7F9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYA8</accession>
    <name>B8LYA8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein 25D9-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_063190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340224.1">
        <property type="nucleotide sequence ID" value="XM_002340183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYA8"/>
    <dbReference type="STRING" id="441959.B8LYA8"/>
    <dbReference type="GeneID" id="8099973"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_063190"/>
    <dbReference type="eggNOG" id="KOG1944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066033_1_0_1"/>
    <dbReference type="InParanoid" id="B8LYA8"/>
    <dbReference type="OMA" id="CLGTFFN"/>
    <dbReference type="OrthoDB" id="860at2759"/>
    <dbReference type="PhylomeDB" id="B8LYA8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF93">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN 25D9-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED22837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="246" mass="27470" checksum="FEE5F1E0715959F3" modified="2009-03-03" version="1">MSVKFQQETIRTTGVKAEDLTPKDLVHKVGERLTGGDTHTGYLAAYLKQLQTNPLRTKMLTSGVLSALQEFIASWLAHDVSKHGHYFSSRVPKMALYGMFISAPLGHVLIGILQKIFAGRSSLKAKVLQILVSNLIIAPIQNSVYLVSMAIIAGARTFHQVRATVRAGFMPVMKVSWVTSPVALAFAQYFLPEHTWVPFFNIVAFVIGTYVNTHTKKKRLEALRRQYDQRRGGPPPPGSEYGRRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYI1</accession>
    <name>B8LYI1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRAL/TRIO domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_063850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340297.1">
        <property type="nucleotide sequence ID" value="XM_002340256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYI1"/>
    <dbReference type="FunCoup" id="B8LYI1">
        <property type="interactions" value="172"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LYI1"/>
    <dbReference type="GeneID" id="8106166"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_063850"/>
    <dbReference type="eggNOG" id="KOG1470">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014001_1_1_1"/>
    <dbReference type="InParanoid" id="B8LYI1"/>
    <dbReference type="OMA" id="DIHARPC"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="PhylomeDB" id="B8LYI1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000013">
        <property type="entry name" value="Phosphatidylinositol transfer protein PDR16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="137"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="339" mass="38371" checksum="6D7FD0A860025BFD" modified="2009-03-03" version="1">MAERTKQEAVADAVALANIEQELNLPKSAADGLIKKPFGHPAAGVKIPSAAELTADQTKKYDEVLKTVSGFTSVPTSPAKNASESPLTDDERMFLTRECLLRFLRATKWNVADAIKRIRSTLAWRRDYISDKLTADYISIENETGKQILEGYDVDGRPCLYLLPSRQNTQKSPRQIEHLVFMLERVIDLMPAGQENLALVVNFNETKSGQNATIGQAKQTLDILQNHYPERLGRALVINVPWIIWGFFKIITPFIDPVTVQKLKFNEDLREHVPPSQLLSSCGGDVQFEYDHSVYWPTLNKLADNRRQQMRERWVRAGRHIGESEFYLRGGTEKSLFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0W7</accession>
    <name>B8M0W7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_089860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478710.1">
        <property type="nucleotide sequence ID" value="XM_002478665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0W7"/>
    <dbReference type="STRING" id="441959.B8M0W7"/>
    <dbReference type="GeneID" id="8108074"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_089860"/>
    <dbReference type="HOGENOM" id="CLU_061238_0_0_1"/>
    <dbReference type="InParanoid" id="B8M0W7"/>
    <dbReference type="OrthoDB" id="4230717at2759"/>
    <dbReference type="PhylomeDB" id="B8M0W7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="254" mass="28643" checksum="6EBC24A19C0A49F4" modified="2009-03-03" version="1">MDSQISTSNESQLAANIAAAALQATESIIITSSPPPPVRSQPTTDTQGTTDSQATSYNSTDDSDSNEASISQNTASQVKNNKRGRSLKDEELSLLFKCALDLKLDYKPKREYWEAVEDRFVRLIGHSYSWKSCKSHIERLSKKRRLYLAQYVTGREAEATSELDELIDQWNDFIDGYEKDEAEKLAEKNKYKENSQLVLAYRDQLVSTGLQKSKKQAPEELKPSEDDTGSDNRKVPDIPHGRQKSGLSRKRYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1V6</accession>
    <name>B8M1V6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Small nuclear ribonucleoprotein (LSM7), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_085650</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478297.1">
        <property type="nucleotide sequence ID" value="XM_002478252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1V6"/>
    <dbReference type="FunCoup" id="B8M1V6">
        <property type="interactions" value="769"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M1V6"/>
    <dbReference type="GeneID" id="8104530"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_085650"/>
    <dbReference type="eggNOG" id="KOG1781">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_3_0_1"/>
    <dbReference type="InParanoid" id="B8M1V6"/>
    <dbReference type="OMA" id="PFVQQEE"/>
    <dbReference type="OrthoDB" id="274944at2759"/>
    <dbReference type="PhylomeDB" id="B8M1V6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01729">
        <property type="entry name" value="LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000043">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017132">
        <property type="entry name" value="Lsm7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="56"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED21334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="144" mass="15455" checksum="E1EBC988519CE352" modified="2009-03-03" version="1">MSERGSFRGGGNRGPRGGGGGDRRGGGSTHRGGGREGGGARDRGHGDNQQEKPKKENILDLTKYMDKEVNVKFNGGREVSGILKGYDQLMNLVLDDVKEKMRDESGNETTRSLGLIVARGTLLVLISPADGTEEIANPFVQQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8M225</accession>
    <name>B8M225_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Oligopeptide transporter, OPT family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_087250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478452.1">
        <property type="nucleotide sequence ID" value="XM_002478407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M225"/>
    <dbReference type="FunCoup" id="B8M225">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M225"/>
    <dbReference type="GeneID" id="8109510"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_087250"/>
    <dbReference type="eggNOG" id="ENOG502QQ2H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010539_2_0_1"/>
    <dbReference type="InParanoid" id="B8M225"/>
    <dbReference type="OMA" id="TPTAYVW"/>
    <dbReference type="OrthoDB" id="627262at2759"/>
    <dbReference type="PhylomeDB" id="B8M225"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF0">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="562"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="661"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="697"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED21489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="791" mass="84402" checksum="D5B23A4459805ED2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8M243</accession>
    <name>B8M243_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_087430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins. Involved in mitophagy. Required for the switch to necrotrophic growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The mitochondrial prohibitin complex consists of two subunits (PHB1 and PHB2). The subunits assemble into a membrane-associated ring-shaped supercomplex of approximately 1 mDa. Interacts with ATG24/SNX4; the interaction is direct and plays a role in mitophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
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        <location>
            <begin position="1"/>
            <end position="20"/>
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        <source>
            <dbReference type="SMART" id="SM00244"/>
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        <source>
            <dbReference type="EMBL" id="EED21507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="278" mass="30603" checksum="DF4AEA05C16D0DA2" modified="2009-03-03" version="1">MASPNALLRWFALPIAGALAIDASMYDVKGGSRAVIFDRLTGVQEKVVGEGTHFLIPWLQRSIIYDVRTKPRNISTTTGSKDLQMVSLTLRVLHRPEVPNLPKIYQSYGTDYDERVLPSIGNEVLKAIVAQFDAAELITQREAVSNRIRTDLTRRAEQFNIALEDVSITHMTFGKEFTRAVEQKQIAQQDAERARFIVERAEQERQANVIRAEGEAESAEIISKAVAKAGTGLIEIRRIDASKEIAATLASNPNVTYLPGGGEGKEGKGTSLLLGLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8M292</accession>
    <name>B8M292_TALSN</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
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        <property type="protein sequence ID" value="EED21556.1"/>
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    <dbReference type="InParanoid" id="B8M292"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
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        <property type="entry name" value="Transp_cyt_pur"/>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        <location>
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        </location>
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        <location>
            <begin position="534"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED21556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="560" mass="62316" checksum="3B43623D5060DECA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3K7</accession>
    <name>B8M3K7_TALSN</name>
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        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Complex I-B15</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">NADH-ubiquinone oxidoreductase B15 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_096280</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFB4 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479342.1">
        <property type="nucleotide sequence ID" value="XM_002479297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3K7"/>
    <dbReference type="STRING" id="441959.B8M3K7"/>
    <dbReference type="GeneID" id="8103471"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_096280"/>
    <dbReference type="eggNOG" id="ENOG502S8RT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_183941_2_0_1"/>
    <dbReference type="InParanoid" id="B8M3K7"/>
    <dbReference type="OMA" id="RYKYWRW"/>
    <dbReference type="OrthoDB" id="15108at2759"/>
    <dbReference type="PhylomeDB" id="B8M3K7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009866">
        <property type="entry name" value="NADH_UbQ_OxRdtase_NDUFB4_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39476:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39476">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE 6.6KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07225">
        <property type="entry name" value="NDUF_B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED22379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="74" mass="8548" checksum="16FEE7C5ECFACA48" modified="2009-03-03" version="1">MAGPSKSLVLDPALQKYYELNANRYKYFRWTPRNAWLTLVYAGIVPGIIGYIAYSTDGKYDLRGKRRGDTVVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3N1</accession>
    <name>B8M3N1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_096520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479366.1">
        <property type="nucleotide sequence ID" value="XM_002479321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3N1"/>
    <dbReference type="STRING" id="441959.B8M3N1"/>
    <dbReference type="GeneID" id="8103495"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_096520"/>
    <dbReference type="eggNOG" id="ENOG502SKYR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011243_1_0_1"/>
    <dbReference type="InParanoid" id="B8M3N1"/>
    <dbReference type="OMA" id="PPGFRRY"/>
    <dbReference type="OrthoDB" id="4202871at2759"/>
    <dbReference type="PhylomeDB" id="B8M3N1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="604" mass="67398" checksum="9FE97CD81BBE9129" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3Y8</accession>
    <name>B8M3Y8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRO domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_039320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002481120.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="B8M3Y8">
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    </dbReference>
    <dbReference type="STRING" id="441959.B8M3Y8"/>
    <dbReference type="GeneID" id="8109270"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_039320"/>
    <dbReference type="eggNOG" id="KOG2220">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003661_0_0_1"/>
    <dbReference type="InParanoid" id="B8M3Y8"/>
    <dbReference type="OMA" id="CHAANQS"/>
    <dbReference type="OrthoDB" id="2141925at2759"/>
    <dbReference type="PhylomeDB" id="B8M3Y8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09242">
        <property type="entry name" value="BRO1_ScBro1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09237">
        <property type="entry name" value="V_ScBro1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF30">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="8">
        <location>
            <begin position="5"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="564"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="762"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="880"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="595"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="763"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="778"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="795"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="819"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="838"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="916"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="934"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="960"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="989"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED20731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1017" mass="112621" checksum="9D21F4D661AFFFEE" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3Z5</accession>
    <name>B8M3Z5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transketolase, putative</fullName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_039380</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.3" evidence="11"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481172.1">
        <property type="nucleotide sequence ID" value="XM_002481127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3Z5"/>
    <dbReference type="STRING" id="441959.B8M3Z5"/>
    <dbReference type="GeneID" id="8109276"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_039380"/>
    <dbReference type="eggNOG" id="KOG0523">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_0_0_1"/>
    <dbReference type="InParanoid" id="B8M3Z5"/>
    <dbReference type="OMA" id="DICNQNG"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="PhylomeDB" id="B8M3Z5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047896">
        <property type="term" value="F:formaldehyde transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
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        <property type="entry name" value="TRANSKETOLASE-LIKE PYRIMIDINE-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
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        <property type="entry name" value="Transket_pyr"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TK C-terminal domain-like"/>
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    </dbReference>
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        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
            <begin position="392"/>
            <end position="567"/>
        </location>
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            <begin position="1"/>
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            <begin position="1"/>
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            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED20738.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="714" mass="78061" checksum="CB687E105E45FCF6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4G9</accession>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <dbReference type="NCBI Taxonomy" id="441959"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="441959.B8M4G9"/>
    <dbReference type="GeneID" id="8106703"/>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
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            <end position="136"/>
        </location>
    </feature>
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        <location>
            <begin position="162"/>
            <end position="216"/>
        </location>
    </feature>
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        <location>
            <begin position="252"/>
            <end position="295"/>
        </location>
    </feature>
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        <location>
            <begin position="464"/>
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        </location>
    </feature>
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        <location>
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            <end position="464"/>
        </location>
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            <end position="104"/>
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            <end position="204"/>
        </location>
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            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="496"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED19164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="534" mass="59342" checksum="3E45C1C7C6C0DFE6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8M578</accession>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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        </lineage>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M578"/>
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    <dbReference type="GeneID" id="8106526"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_029590"/>
    <dbReference type="eggNOG" id="ENOG502SJ3Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035244_2_0_1"/>
    <dbReference type="InParanoid" id="B8M578"/>
    <dbReference type="OMA" id="TSWETFV"/>
    <dbReference type="OrthoDB" id="10039566at2759"/>
    <dbReference type="PhylomeDB" id="B8M578"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DUF3712"/>
    </dbReference>
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        <property type="entry name" value="Tag1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
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    </dbReference>
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        <property type="entry name" value="DUF3712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="111"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="445" mass="48221" checksum="409B76F8721D050C" modified="2009-03-03" version="1">MSDIEKPGEEPPVATGAGAANGTAAAQMKSSPTFLDKLSQFTIGRNRGLLPSEKDAATESDENATPPPPLTFWQKVKLHFRRYWVCHLIALIILLAILLPCLFLLIIPAIAQDLLSSGKIVIDSASILQPTNNSVILSIDSHIYVPGPFTVHTDAEHLQLYVPQVGSDYPMALLNLPATKIHKNTSIGEHGQYTVFENYTSWQQFVHNTIFLDKGGLGLKGKVGTRLGKIKKFTLDLDKTIPSNALNQFKGFSIDSASLVLPAESDGTNLIANATLPNQSVLTLEIGNTTVDIKAGSLTIGKGMIENLYLKPGNNSVQIRGTADLKTILANLGSLIAQQGQYIKNGYLSLTTQVTNISYNGSTIRYYTEEMGKLPLTAQTPVLGLLINSLSGFLHGGTANTTNLTSIIANYTNNRLSHESSSDILNNATHLEMVTRHHLERLVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5J0</accession>
    <name>B8M5J0_TALSN</name>
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        <submittedName>
            <fullName evidence="9">Kinesin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_031430</name>
    </gene>
    <organism evidence="9 10">
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002480273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5J0"/>
    <dbReference type="STRING" id="441959.B8M5J0"/>
    <dbReference type="GeneID" id="8107754"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_031430"/>
    <dbReference type="eggNOG" id="KOG0247">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004757_1_0_1"/>
    <dbReference type="InParanoid" id="B8M5J0"/>
    <dbReference type="OMA" id="NRHPQKA"/>
    <dbReference type="OrthoDB" id="123929at2759"/>
    <dbReference type="PhylomeDB" id="B8M5J0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000091">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000120">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
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    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="150" mass="16494" checksum="6096608C9567B7A8" modified="2009-03-03" version="1">MSDGEETISNPPVAEAEDVEVPAESSGGQMSINDALKGVLKIALIHDGLARGLREASKALDRRQAHMCVLNESCEEEAYKKLVIALCSEHDIPLIKVPNGKELGEWVGLCQIDREGNARKVVNCSCVVVKDWGEESQERSILLNYFQTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8M632</accession>
    <name>B8M632_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_023670</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479466.1">
        <property type="nucleotide sequence ID" value="XM_002479421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M632"/>
    <dbReference type="STRING" id="441959.B8M632"/>
    <dbReference type="GeneID" id="8109549"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_023670"/>
    <dbReference type="eggNOG" id="ENOG502SN0C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_29_0_1"/>
    <dbReference type="InParanoid" id="B8M632"/>
    <dbReference type="OrthoDB" id="5329176at2759"/>
    <dbReference type="PhylomeDB" id="B8M632"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF108">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="2"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="193"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED19032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="265" mass="28719" checksum="A61724C45A86B814" modified="2009-03-03" version="1">MIFGTMYFTIALMVSILIADVFQCTPVAYVYDITIAGGHCIEQGAFFVATATMTIFTDLLVVVIPMIIVYSLQMPIRRKIMVVGILCLGLVATGVGAWRLNQLVEAFFPSHPNPDHTYSIGFVSSAIEINLAVISACCPALKSLLNRIAPRFLGTSGRGTYGKSSNPRYGHGTYIRSNVDPNDSYELGQKKYHNKQQTEISAGESHSGRLPPRSKTAESLSLSDDDGIIAGAMGSIAIVKTTNVSVQRNRRDDHPEKASSVDSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6J8</accession>
    <name>B8M6J8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_027540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479894.1">
        <property type="nucleotide sequence ID" value="XM_002479849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6J8"/>
    <dbReference type="STRING" id="441959.B8M6J8"/>
    <dbReference type="GeneID" id="8109673"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_027540"/>
    <dbReference type="eggNOG" id="ENOG502SP01">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015771_1_1_1"/>
    <dbReference type="InParanoid" id="B8M6J8"/>
    <dbReference type="OMA" id="HLESFIW"/>
    <dbReference type="OrthoDB" id="3469466at2759"/>
    <dbReference type="PhylomeDB" id="B8M6J8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="550" mass="61527" checksum="4F03C101A35047D3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6L6</accession>
    <name>B8M6L6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribose-phosphate pyrophosphokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_027720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479912.1">
        <property type="nucleotide sequence ID" value="XM_002479867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6L6"/>
    <dbReference type="FunCoup" id="B8M6L6">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M6L6"/>
    <dbReference type="GeneID" id="8109691"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_027720"/>
    <dbReference type="eggNOG" id="KOG1448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_0_1_1"/>
    <dbReference type="InParanoid" id="B8M6L6"/>
    <dbReference type="OMA" id="TCDLHES"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="PhylomeDB" id="B8M6L6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000063">
        <property type="entry name" value="Phosphoribosylpyrophosphate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000030">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000047">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF36">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED19478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="435" mass="47356" checksum="6F5E93C6696CECB2" modified="2009-03-03" version="1">MVRNIVVIGGTSHPQLTQTICNHLGIPQANVLLSKFAVGETRVEIQESVREKDVYIIQSGGGKVNDHLLELLITISACKTASAKRVTAVLPLFPYSRQSDIPYKKSGAPLVKSSAHNQFTFDSTPSTPHPGKVESQGMNNDVESLQKSLARAQIESESNGSPVKQRPIANGGKRSDTLESARSESSLANGVNNDETASVSSGSLAKVSEFEPRPGYRQWVAQAGTLIADLLTCAGADHIITMDLHDPQYQGFFDIPVDNLYGRPLLKRYIQRHIPDYKNCIIVSPDAGGAKRATAIADSMGVEFALIHKERRPTRISDRQNATMMLVGDVRDRTAILIDDLADTSNTITRAAKLLKKEGAAKVYALVTHGILSGDAIERINASALDKVVVTNTVDQTEHCKRCPKLEVLEVGNVFAEAIRRVHHGESISVLFQYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7B4</accession>
    <name>B8M7B4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_035600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480768.1">
        <property type="nucleotide sequence ID" value="XM_002480723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7B4"/>
    <dbReference type="STRING" id="441959.B8M7B4"/>
    <dbReference type="GeneID" id="8107510"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_035600"/>
    <dbReference type="eggNOG" id="ENOG502SFRW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_30_0_1"/>
    <dbReference type="InParanoid" id="B8M7B4"/>
    <dbReference type="OrthoDB" id="4226915at2759"/>
    <dbReference type="PhylomeDB" id="B8M7B4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="278" mass="30673" checksum="39995E18FE316FE9" modified="2009-03-03" version="1">MGHGHEVFDAELVGMLLGAQNAIDRLRSTRPGPGQALVLRAHRAAEKLALRGQPVTIQWVPGHSGIEGNEQADQAAKRAASKQTAPGFEHLSLAHVRRACTEARRAAVSEWAQINAVQGRHRDGRVYKMPRGWNLDPVAGKAPKRVASRYYQLKTGHAPIGTYLYRIGQRESPECQACKEPHETVRHVLFECRGRRAGRRTLYQALKKAGVPLPTAAEEDPEARLFAEPRATQGLLQFVAEANLFNDNERTAREAEISDVWGWDTLEEGGLGVTLEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7B7</accession>
    <name>B8M7B7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_035630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480771.1">
        <property type="nucleotide sequence ID" value="XM_002480726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7B7"/>
    <dbReference type="GeneID" id="8107513"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_035630"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_618443_0_0_1"/>
    <dbReference type="InParanoid" id="B8M7B7"/>
    <dbReference type="OrthoDB" id="4226988at2759"/>
    <dbReference type="PhylomeDB" id="B8M7B7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="443" mass="46819" checksum="03F8C925D93D718C" modified="2009-03-03" version="1">MESPERPPGATGDPEIMGPGSGVDSSTPSQEPSQLPPTTRALFAGLGDCQKQSNEPTLSNSDALQAPRQTGETQQAPGTILEKRKASRLIIGSRTPITRSGLSAAPKRKITLTAMRAASAPAEDSLLMGLIEDLNGHLQEAVHQLSAELTTARNVINTQQGLITTLNARLESLETYVNALQSRQILPLDPFAATREVAAHGLPPRAASTGGLAPTPIQLDAAPESRAISESNKGYETSLPGTAAKTTKQPETTAKPLTKPAPTKWATIATNNTQSGGWKTVQYKKQALAPSKALSTTNLKPVSTRSKEERRLIFRRRYPKDAPTALKADILLALNRALAKAGFPDFVRAVDSGYAASGALTVLLERGTRSSTLVPVYNDTLLAAVRQTDPVDLAMTRTVGPSSRPATLPSGGSGRRLTTLTAPEGHRIFGGSPAKRPSRPAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7F7</accession>
    <name>B8M7F7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SNF2 family helicase/ATPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_036030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480811.1">
        <property type="nucleotide sequence ID" value="XM_002480766.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B8M7F7">
        <property type="interactions" value="244"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M7F7"/>
    <dbReference type="GeneID" id="8101874"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_036030"/>
    <dbReference type="eggNOG" id="KOG0298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001592_2_0_1"/>
    <dbReference type="InParanoid" id="B8M7F7"/>
    <dbReference type="OMA" id="KAVFFCA"/>
    <dbReference type="OrthoDB" id="5330228at2759"/>
    <dbReference type="PhylomeDB" id="B8M7F7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18070">
        <property type="entry name" value="DEXQc_SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000059">
        <property type="entry name" value="SNF2 family helicase/ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001870">
        <property type="entry name" value="SNF2 family helicase/ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052583">
        <property type="entry name" value="ATP-helicase/E3_Ub-Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059033">
        <property type="entry name" value="C144_05_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26021">
        <property type="entry name" value="Ferritin_C144_05"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="335"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="1134"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="1238"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="735"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1377"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="735"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="747"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1385"/>
            <end position="1396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED20377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1481" mass="168907" checksum="D0FE7F74EC3855EA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>B8M889</accession>
    <name>B8M889_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-binding cassette transporter, putative</fullName>
            <ecNumber evidence="12">3.6.3.44</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_036280</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.44" evidence="12"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480836.1">
        <property type="nucleotide sequence ID" value="XM_002480791.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M889"/>
    <dbReference type="GeneID" id="8101899"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_036280"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_17_2_1"/>
    <dbReference type="InParanoid" id="B8M889"/>
    <dbReference type="OMA" id="QDYWLRW"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="PhylomeDB" id="B8M889"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000251">
        <property type="entry name" value="ABC transporter B family member 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="819"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="910"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1006"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1039"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="133"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="458"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="778"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1103"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED20402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1348" mass="146689" checksum="82D3CDF0F6BA9B1A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8G2</accession>
    <name>B8M8G2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">xylan 1,4-beta-xylosidase</fullName>
            <ecNumber evidence="13">3.2.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_036960</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of (1-&gt;4)-beta-D-xylans, to remove successive D-xylose residues from the non-reducing termini.</text>
            <dbReference type="EC" id="3.2.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="13"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480909.1">
        <property type="nucleotide sequence ID" value="XM_002480864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8G2"/>
    <dbReference type="STRING" id="441959.B8M8G2"/>
    <dbReference type="GeneID" id="8100542"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_036960"/>
    <dbReference type="eggNOG" id="ENOG502QQ55">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_5_3_1"/>
    <dbReference type="InParanoid" id="B8M8G2"/>
    <dbReference type="OMA" id="DIWQYHN"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="PhylomeDB" id="B8M8G2"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000007">
        <property type="entry name" value="Exo-1,4-beta-xylosidase xlnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
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            <dbReference type="ARBA" id="ARBA00026107"/>
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        </source>
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        <source>
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        </source>
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    <sequence length="757" mass="82459" checksum="8074FD2EF473135B" modified="2009-03-03" version="1"> </sequence>
</entry>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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                <person name="Fedorova-Abrams N.D."/>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01310"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED20524.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1309" mass="146674" checksum="894BF5574970425E" modified="2009-03-03" version="1"> </sequence>
</entry>
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    <accession>B8M8Z1</accession>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="136" mass="15633" checksum="3B871C59EF8A879A" modified="2009-03-03" version="1">MDLSQSQAEEAVPSNDRVCKKQRDREEESRYIIDDLKSGNFILLLQETPKVKMSHCQAWRCMPRKRTGKPVIKSHYRFMLKDISVPSKPKGEYYHVTCLERLLPNLSALVRDGHLKMDGYISAPHNGKVCLESSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9A2</accession>
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            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
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            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
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        <property type="protein sequence ID" value="EED17662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002481609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9A2"/>
    <dbReference type="FunCoup" id="B8M9A2">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M9A2"/>
    <dbReference type="GeneID" id="8101280"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_114700"/>
    <dbReference type="eggNOG" id="KOG1863">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003155_0_0_1"/>
    <dbReference type="InParanoid" id="B8M9A2"/>
    <dbReference type="OMA" id="MDIGDAY"/>
    <dbReference type="OrthoDB" id="2420415at2759"/>
    <dbReference type="PhylomeDB" id="B8M9A2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02666">
        <property type="entry name" value="Peptidase_C19J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000122">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025305">
        <property type="entry name" value="UCH_repeat_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13446">
        <property type="entry name" value="RPT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="614"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="747"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="813"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1225"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="748"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1260"/>
            <end position="1273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED17662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1273" mass="142555" checksum="0288186BA1D4720B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAK1</accession>
    <name>B8MAK1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_112580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481417.1">
        <property type="nucleotide sequence ID" value="XM_002481372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAK1"/>
    <dbReference type="GeneID" id="8105723"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_112580"/>
    <dbReference type="eggNOG" id="ENOG502S7P4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110778_0_0_1"/>
    <dbReference type="InParanoid" id="B8MAK1"/>
    <dbReference type="OMA" id="RTGVWAW"/>
    <dbReference type="OrthoDB" id="2122304at2759"/>
    <dbReference type="PhylomeDB" id="B8MAK1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371:SF1">
        <property type="entry name" value="BLR7753 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371">
        <property type="entry name" value="INNER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED17425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="158" mass="17018" checksum="4972937D6F9EE9F2" modified="2009-03-03" version="1">MAGNNNYSMHSIVAAYGVGLAPHGYYFIKMMANAKGQASNILPRENLTNLKGRIPAHVWDKLARARGAHLNALESLPMFAAAMLAGNLAKLPSSELNTLAVEYIGARLLYTAVYLGVRSEAASYLRTGIWAWSISIPVWGLIKAGRMLNSSSELSGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAX9</accession>
    <name>B8MAX9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_124090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482672.1">
        <property type="nucleotide sequence ID" value="XM_002482627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAX9"/>
    <dbReference type="FunCoup" id="B8MAX9">
        <property type="interactions" value="1312"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MAX9"/>
    <dbReference type="GeneID" id="8098360"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_124090"/>
    <dbReference type="eggNOG" id="KOG3184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055156_0_0_1"/>
    <dbReference type="InParanoid" id="B8MAX9"/>
    <dbReference type="OMA" id="IVEPWIA"/>
    <dbReference type="OrthoDB" id="28644at2759"/>
    <dbReference type="PhylomeDB" id="B8MAX9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_uL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="6">
        <location>
            <begin position="14"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="5">
        <location>
            <begin position="90"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED18680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="249" mass="28645" checksum="868F684693364A41" modified="2009-03-03" version="1">MAATTVPTQDQVLVPETLLKKRKSQEAARAARREEAEKKKQANKEKRGVIFKRAESYVKEYRDAEREKIRLARESRKAGTFYVADEPKLVFVIRIKGINKIPPKPRKILQLLRLLQINNGVFVRLNKATSEMLTIINPYIAYGYPNLKTVRELIYKRGYGKVNGQRLPLSDNQIIEENLGKYGIVCVEDLIHEIYTVGPNFKQASNFLWPFKLSNPTGGFHSRKFNHFIEGGDTGNREENINALVRQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCA5</accession>
    <name>B8MCA5_TALSN</name>
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        <submittedName>
            <fullName evidence="3">Universal stress protein family domain protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">TSTA_122810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002482498.1"/>
    </dbReference>
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    <dbReference type="STRING" id="441959.B8MCA5"/>
    <dbReference type="GeneID" id="8097746"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_122810"/>
    <dbReference type="eggNOG" id="ENOG502RYEB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018542_0_1_1"/>
    <dbReference type="InParanoid" id="B8MCA5"/>
    <dbReference type="OMA" id="DEVICLW"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="PhylomeDB" id="B8MCA5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815:SF1">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="128"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED18551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="442" mass="48273" checksum="02B14955C54C16A1" modified="2009-03-03" version="1">MTSATTSPDPVAPILNLPITTESSADSTTSSRSDNRRISFAGEDPPRRRSAQSSGSDSQPLPESTIVSSGRQTPVLDGRFPKRISSPPPPSTYQRGVSFDTFDNRDATDGSFTLKYKHKNYQATRRSRTFLCGTDQNDYSEFALEWLIDELVDDGDEVICLWVVEKDSKIASDASMDEGRYRKEAEKLLSQVIAKNQHDEKAISLVLELAVGKVQDIIQRMIRIYEPAVLIVGTRGRSLSGMQGLLPGSVSKYCLQQSPIPVVVVRPSTKREKKKKKRLADPTRRSYGNILQISEQQGSGLFNKQVSSDTNVAKLPADEAAAVAEAVGLPRHFQHAHTGSDSRLSTTSSTEEDNSKDALRSDSPQLSPDIEDENAGRVLKSPGLGNLDTPPDSEDESDTETTRGRDPSSSDVDETTPSDLSITETEEDITPLTSKLQLADAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCA8</accession>
    <name>B8MCA8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dynamin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_122840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482547.1">
        <property type="nucleotide sequence ID" value="XM_002482502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCA8"/>
    <dbReference type="STRING" id="441959.B8MCA8"/>
    <dbReference type="GeneID" id="8097749"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_122840"/>
    <dbReference type="eggNOG" id="KOG0446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8MCA8"/>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="PhylomeDB" id="B8MCA8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001425">
        <property type="entry name" value="Dynamin GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF149">
        <property type="entry name" value="GTPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="35"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="589"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="559"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="710"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="725"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="748"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="759"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="775"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="789"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="820"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED18555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="937" mass="103824" checksum="43BBDD377A63B8C9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MD95</accession>
    <name>B8MD95_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LCCL domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_114330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481612.1">
        <property type="nucleotide sequence ID" value="XM_002481567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MD95"/>
    <dbReference type="FunCoup" id="B8MD95">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="GeneID" id="8109195"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_114330"/>
    <dbReference type="eggNOG" id="ENOG502QUEX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011125_1_0_1"/>
    <dbReference type="InParanoid" id="B8MD95"/>
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    <dbReference type="OrthoDB" id="441660at2759"/>
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        <property type="entry name" value="LCCL"/>
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    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331:SF1">
        <property type="entry name" value="CYSTEINE RICH SECRETORY PROTEIN LCCL DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G08630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03815">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00603">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
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        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="378"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="3">
        <location>
            <begin position="159"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED17620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="652" mass="71842" checksum="C930436A6932CC36" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDK7</accession>
    <name>B8MDK7_TALSN</name>
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            <fullName evidence="11">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
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        <name evidence="17" type="ORF">TSTA_117480</name>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481962.1">
        <property type="nucleotide sequence ID" value="XM_002481917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MDK7"/>
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    </dbReference>
    <dbReference type="STRING" id="441959.B8MDK7"/>
    <dbReference type="GeneID" id="8105806"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_117480"/>
    <dbReference type="eggNOG" id="KOG1147">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_1_2_1"/>
    <dbReference type="InParanoid" id="B8MDK7"/>
    <dbReference type="OMA" id="CPVVDSH"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="PhylomeDB" id="B8MDK7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1160.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000004">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000036">
        <property type="entry name" value="Putative glutamyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="entry name" value="Glutamyl-trna Synthetase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.800.10">
        <property type="entry name" value="Glutamyl-tRNA Synthetase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="14">
        <location>
            <begin position="206"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="15">
        <location>
            <begin position="513"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="16">
        <location>
            <begin position="620"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EED17970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="716" mass="80936" checksum="3C841460B11036C7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDY0</accession>
    <name>B8MDY0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_011660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483291.1">
        <property type="nucleotide sequence ID" value="XM_002483246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MDY0"/>
    <dbReference type="FunCoup" id="B8MDY0">
        <property type="interactions" value="1583"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MDY0"/>
    <dbReference type="GeneID" id="8107799"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_011660"/>
    <dbReference type="eggNOG" id="KOG2920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038704_1_1_1"/>
    <dbReference type="InParanoid" id="B8MDY0"/>
    <dbReference type="OMA" id="NLLLTWH"/>
    <dbReference type="OrthoDB" id="1723750at2759"/>
    <dbReference type="PhylomeDB" id="B8MDY0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED16057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="405" mass="45004" checksum="5343B51592BEB141" modified="2009-03-03" version="1">MASTFRFGFSGDDIDVDIDNDVEVDPGNNVSEKSQAEDVNAPDMFPAVRHALKDWTTNLPSQLSYNTFKVEISNPDHQTINNNEKNSTQTNKTITIARRELFDVRTQLMAEDDDSGFATGHTELIADLEQGDLKPNFYEGGFKTWECSLDLADVLLNSKYIGEGEGEDEGVNVIELGCGTAAPSLMLFAQVLLSSTTDQRQKRRFRFTLADYNSTVLRMVTLCNFLLTWWVNSPSSPRRTSTDGAVNGKDVEEEGELDIDTTLLDTFQADLANRVIELDFISGGWSPEFVRLVLNRGQQFTENVSTLILASETIYSPSSLGVFSETLLELLRSSAGVQQERRNKSTALIAAKKVYFGVGGGVDEFLQVLHQQPLQDEEVVQVQERREITSGGVKRVVLEIGFSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8ME19</accession>
    <name>B8ME19_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sulfatase, putative</fullName>
            <ecNumber evidence="10">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_012050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="10"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483330.1">
        <property type="nucleotide sequence ID" value="XM_002483285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ME19"/>
    <dbReference type="STRING" id="441959.B8ME19"/>
    <dbReference type="GeneID" id="8104053"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_012050"/>
    <dbReference type="eggNOG" id="KOG3867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_11_1_1"/>
    <dbReference type="InParanoid" id="B8ME19"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="PhylomeDB" id="B8ME19"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16025">
        <property type="entry name" value="PAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF33">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="9">
        <location>
            <begin position="13"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="591"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="591"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED16096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="891" mass="99246" checksum="E7F19A2E33C194DB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8ME73</accession>
    <name>B8ME73_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thioredoxin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_015840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483734.1">
        <property type="nucleotide sequence ID" value="XM_002483689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ME73"/>
    <dbReference type="STRING" id="441959.B8ME73"/>
    <dbReference type="GeneID" id="8106357"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_015840"/>
    <dbReference type="eggNOG" id="KOG0908">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072377_0_0_1"/>
    <dbReference type="InParanoid" id="B8ME73"/>
    <dbReference type="OMA" id="PIFEMFP"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="PhylomeDB" id="B8ME73"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="PITH" evidence="5">
        <location>
            <begin position="133"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="109"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED16500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="335" mass="36927" checksum="8C3E11A0C5F3F5E5" modified="2009-03-03" version="1">MSLVHISSKEQFSSLLTSSTIVVTDFYADWCGPCKAIAPMYEQLANQLSRPNQITFTKVNVDQQQDIAKAYGVTAMPTFVMFKRGRVVTTIRGADPNKLSEAIRKLATEANNMESSTGGESSDAAGSSGSSWTGASLPRGYADVTDTVTIKDLDMANRDSEKGSAKVIFDKSKPSALDNNKGKDKEPDWVESDTDEQLMLYIPFNSTLKVHSLQITSLPPKDSEGEDDDDEVPMRPKTLRLYTNRSTILGFEEAEDIDPVQSVTIEPEQWDDKTGTAKVELRFVKFQKVNSMVIFFVDGDGDGEKIRVDRIRIIGEAGQAREMGKLEKIGDEAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8ME75</accession>
    <name>B8ME75_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="4">2.7.1.108</ecNumber>
            <ecNumber evidence="3">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Diphthamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSTA_015860</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="4"/>
    <dbReference type="EC" id="6.3.1.14" evidence="3"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483736.1">
        <property type="nucleotide sequence ID" value="XM_002483691.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8ME75"/>
    <dbReference type="GeneID" id="8106359"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_015860"/>
    <dbReference type="eggNOG" id="KOG2316">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2468">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_244815_0_0_1"/>
    <dbReference type="InParanoid" id="B8ME75"/>
    <dbReference type="OMA" id="HVPPLIM"/>
    <dbReference type="OrthoDB" id="377083at2759"/>
    <dbReference type="PhylomeDB" id="B8ME75"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004168">
        <property type="term" value="F:dolichol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06155">
        <property type="entry name" value="eu_AANH_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06156">
        <property type="entry name" value="eu_AANH_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1204"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1383"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1475"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1528"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1573"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1618"/>
            <end position="1637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1658"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1695"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="domain" description="Diphthamide synthase" evidence="17">
        <location>
            <begin position="117"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="848"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1267"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="849"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="862"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="890"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1284"/>
            <end position="1294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EED16502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1738" mass="192407" checksum="EAC7BE3D43608976" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEF7</accession>
    <name>B8MEF7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Esterase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_016610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483818.1">
        <property type="nucleotide sequence ID" value="XM_002483773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEF7"/>
    <dbReference type="STRING" id="441959.B8MEF7"/>
    <dbReference type="GeneID" id="8103634"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_016610"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_6_4_1"/>
    <dbReference type="InParanoid" id="B8MEF7"/>
    <dbReference type="OMA" id="FAHYNHP"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="PhylomeDB" id="B8MEF7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="95"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED16584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="360" mass="40319" checksum="CAC27BDCEB51880B" modified="2009-03-03" version="1">MQESVNAIPDKYLHNLDPEWKEIWTKHGQDVVGAHLVTIEEFRQCPAKYSFTYPTWDGPDVHNVQDYIVPVQDPEGTITCRVYTPSGSGPFPVHLNFHGGGWVLGGLKTEAAWCRSVCNESGIVVIDVDYRLAPEFAFPVAIYDCWTALQWAISNANTLNIDPTSASIGGLSSGGLITAVLAHFARDSIPKIDLKLQLMIVPATDMRYVPISADKPTRLTPETCPYPSAIFCADLPWSPLERESWFLKYYISDDPETRSKILEDWRMTPVLSPCLRNLAPAHIVTAEYDVERDEAEHYGRMLQAAGNQVSMKRYPGVPHAFAHYNHPSRGLSRSHEFIKDTAQLLSHVHSKMMKPLSSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEH2</accession>
    <name>B8MEH2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MYB DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_016740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED16599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002483788.1"/>
    </dbReference>
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    <dbReference type="STRING" id="441959.B8MEH2"/>
    <dbReference type="GeneID" id="8103647"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066710_0_0_1"/>
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    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="138"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="138"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="194"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED16599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="237" mass="26473" checksum="D865E0308F7C697F" modified="2009-03-03" version="1">MYQMNFQISDHRQTPTVFSMMSSSPMSKRVKGSALNRSSAQQQQQQQQQQQQQQQQAALSVTGLTPTSAYPLTTPAAQTPPLPQPHHQLQSQQVNARKRRTPPSATTATGIPVIPGSAVVAPVMSDIPGGLAEPPPKKKGRTNTPWTAEEEQRLKQLRDLGKSWSEIAKTFPARTEGSVKKHWYKDMHYAEFGEDESVALREAIKEYEANKWKVIGQKIGKPAKACEQYAKEHFKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
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    <name>B8MEI5_TALSN</name>
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        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L29</fullName>
        </alternativeName>
    </protein>
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        <name evidence="9" type="ORF">TSTA_016870</name>
    </gene>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EED16612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002483801.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="B8MEI5">
        <property type="interactions" value="993"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MEI5"/>
    <dbReference type="GeneID" id="8103660"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_016870"/>
    <dbReference type="eggNOG" id="KOG1742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109163_1_0_1"/>
    <dbReference type="InParanoid" id="B8MEI5"/>
    <dbReference type="OMA" id="WGRVGQH"/>
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    <dbReference type="PhylomeDB" id="B8MEI5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="60S ribosomal protein L27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="8">
        <location>
            <begin position="72"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00080124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED16612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="150" mass="16887" checksum="61B610CDCD383428" modified="2009-03-03" version="1">MPTRLTKTRKHRGHVSAGHGRIGKHRKHPGGRGMAGGQHHHRTNLDKYHPGYFGKVGMRHFHLQRNHYWKPTINLDKLWSLVPEETREKYVAGNAPSDKAIVLDLLSLGYAKVLGKGRLPEVPIVVKARYVSKEAERKIKEAGGVIELVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEW0</accession>
    <name>B8MEW0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_022970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484477.1">
        <property type="nucleotide sequence ID" value="XM_002484432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEW0"/>
    <dbReference type="STRING" id="441959.B8MEW0"/>
    <dbReference type="GeneID" id="8107134"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_022970"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1016275_0_0_1"/>
    <dbReference type="InParanoid" id="B8MEW0"/>
    <dbReference type="OMA" id="TEHPASC"/>
    <dbReference type="OrthoDB" id="3799035at2759"/>
    <dbReference type="PhylomeDB" id="B8MEW0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="261" mass="29833" checksum="338BD3940445B7DF" modified="2009-03-03" version="1" fragment="single">PKKYVLKLRRSLYGLKQAPRIWWDRMTSFLLKAGFYQCDAEPAIFICSLDNKFLILLLFVDDILLTVILHQKAYIQRILERFNAPTNPVATPLDPKHPLIEATNAESLNETDALEYRAAVGELIYLMICTRPDLAFALSRLSKFMQKPGIKHAAALKRVLRLATASYEVIWLRKLILAILPQYAEHTMPSNTIHCDNQGAIAIANQPSHSPSTRSKHIDIRFHVIREAIANGLIRLEYIRTTEITADILTKALPKELHEYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEZ2</accession>
    <name>B8MEZ2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_008860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482995.1">
        <property type="nucleotide sequence ID" value="XM_002482950.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MEZ2"/>
    <dbReference type="GeneID" id="8109993"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_008860"/>
    <dbReference type="eggNOG" id="KOG0351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004144_0_0_1"/>
    <dbReference type="InParanoid" id="B8MEZ2"/>
    <dbReference type="OrthoDB" id="5153301at2759"/>
    <dbReference type="PhylomeDB" id="B8MEZ2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF154">
        <property type="entry name" value="RECQ HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="793"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="985"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="714"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="714"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED15761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1363" mass="156178" checksum="3B0308BDD6C0A097" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFG8</accession>
    <name>B8MFG8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mannosylphosphorylation protein (Mnn4), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_017760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483936.1">
        <property type="nucleotide sequence ID" value="XM_002483891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFG8"/>
    <dbReference type="STRING" id="441959.B8MFG8"/>
    <dbReference type="GeneID" id="8109033"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_017760"/>
    <dbReference type="eggNOG" id="ENOG502QREF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052528_2_0_1"/>
    <dbReference type="InParanoid" id="B8MFG8"/>
    <dbReference type="OMA" id="FQGHHFN"/>
    <dbReference type="OrthoDB" id="444255at2759"/>
    <dbReference type="PhylomeDB" id="B8MFG8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009644">
        <property type="entry name" value="FKTN/MNN4/W02B3.4-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407">
        <property type="entry name" value="FUKUTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407:SF32">
        <property type="entry name" value="PROTEIN (MNN4), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002875072" evidence="5">
        <location>
            <begin position="27"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="6">
        <location>
            <begin position="95"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="6">
        <location>
            <begin position="212"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED16702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="320" mass="36841" checksum="9D8446BDF5918C69" modified="2009-03-03" version="1">MILSSYTMRTSLVICGLIAATANAAALNANFMEERKKLAKEWSGNGGDPAAKYFHEASFSYHYDGRFTDKALDREEQSAHLSALITTYLSFMDELDVETWIMHGTLLAWWWNQRIFPWDDDLDVQVSEPGIHFLAENYNMTEHHFEIPGVPGGRKYMLEINPHYVIRTTMDWRNVIDGRWIDTSSGLFIDITAVRADDNRRAQGEVGALMCKDSHRFQENEIFPLRRTVFEGVPAKVPYAYTKLLADEYGEKSMTNPRFNGYTFSEEFQQWIKNSEVDTVIEEHEKQPEGKEKVKIENSIQRVDNSTFNSTTFNSTNNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFR3</accession>
    <name>B8MFR3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">rRNA processing protein Pwp1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_021140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484287.1">
        <property type="nucleotide sequence ID" value="XM_002484242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFR3"/>
    <dbReference type="FunCoup" id="B8MFR3">
        <property type="interactions" value="1437"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MFR3"/>
    <dbReference type="GeneID" id="8109371"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_021140"/>
    <dbReference type="eggNOG" id="KOG0270">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023867_0_1_1"/>
    <dbReference type="InParanoid" id="B8MFR3"/>
    <dbReference type="OMA" id="CFVPRGV"/>
    <dbReference type="OrthoDB" id="270624at2759"/>
    <dbReference type="PhylomeDB" id="B8MFR3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000457">
        <property type="entry name" value="rRNA processing protein Pwp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044285">
        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="262"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="398"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="47"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="493"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED17053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="540" mass="60437" checksum="15770B11D33194B0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8MG51</accession>
    <name>B8MG51_TALSN</name>
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        <submittedName>
            <fullName evidence="4">Oxidoreductase, short-chain dehydrogenase/reductase family, putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">TSTA_010360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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    <dbReference type="GeneID" id="8105675"/>
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    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
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    <dbReference type="OMA" id="GPCFLAK"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="PhylomeDB" id="B8MG51"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GDHRDH"/>
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    </dbReference>
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        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED15918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="243" mass="25801" checksum="50EC64915A90AF7F" modified="2009-03-03" version="1">MSYVGKVVLITGGSKGIGRAVTEQFVALGAKVAINYSSDSSAADELVKTLGENNVLPIKADAGSVVSTKEMVEQTVSRFGKIDILIPNAGIMPLANLENVTEEMFDNIYQVNVKGPLFLAKAAVPHMPEGSHIVFLSTSLCHSNTILPPQLLYCSTKGAIEQITRLLSKDLASKGIIVNCVAPGPTATELFMRGKPDTLVDAIKKHSPFNRLGTPEEIAEAIVYLSGTSWVAGQTVRCNGGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGW7</accession>
    <name>B8MGW7_TALSN</name>
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        <submittedName>
            <fullName evidence="12">Chromatin assembly factor 1 subunit B, putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="12" type="ORF">TSTA_014390</name>
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    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483582.1">
        <property type="nucleotide sequence ID" value="XM_002483537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGW7"/>
    <dbReference type="FunCoup" id="B8MGW7">
        <property type="interactions" value="828"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MGW7"/>
    <dbReference type="GeneID" id="8107822"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_014390"/>
    <dbReference type="eggNOG" id="KOG1009">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010127_3_1_1"/>
    <dbReference type="InParanoid" id="B8MGW7"/>
    <dbReference type="OMA" id="CIVSNLH"/>
    <dbReference type="OrthoDB" id="71227at2759"/>
    <dbReference type="PhylomeDB" id="B8MGW7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Chromatin assembly factor 1 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045145">
        <property type="entry name" value="PTHR15271"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271:SF4">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="59"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="117"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="159"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="308"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="211"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="403"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="534"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="267"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="443"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="568"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="587"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="602"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="617"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="643"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="660"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="727"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED16348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="736" mass="78493" checksum="A31F85CD0854ED1B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHP9</accession>
    <name>B8MHP9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C6 finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_011400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483264.1">
        <property type="nucleotide sequence ID" value="XM_002483219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHP9"/>
    <dbReference type="STRING" id="441959.B8MHP9"/>
    <dbReference type="GeneID" id="8109987"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_011400"/>
    <dbReference type="eggNOG" id="ENOG502RA69">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_594457_0_0_1"/>
    <dbReference type="InParanoid" id="B8MHP9"/>
    <dbReference type="OMA" id="THISQCH"/>
    <dbReference type="OrthoDB" id="3469225at2759"/>
    <dbReference type="PhylomeDB" id="B8MHP9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED16030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="44133" checksum="28874136B154E235" modified="2009-03-03" version="1">MRRRVMREIGFSRRKKVNTKPDKEKRTHSSDMAEWISQTDQLNTYLPPSLEMGLGYPTLLDANARRILSHMFSDFITSYLRIYRDKWFPSTIGNSSVFDQMLSTYAKHLLNWQQATTRDNINNDLNEIILSGHTKTLVYVRLNLGSTGDELEKVAAAIVSLACYAHLCLDMESWKMHMAAITRIFEIRRDWNPRLIGLVEWVDSIGSYDLDTPPILETTDPVAHEVVESYLLPPDGNQIITYLNNSLVSPGLIDAFTALHSLNTQLILLHSALGKSLWQTITPIEIDRLVDPVVRKFLSPSARLDLPLSIGACLRSGALLYLAEFRRRSGISPVVVDGLELLKDDVSAIDRSLWIWLLTIGAIAERSDGFFHQWLATEIAGFGIRSLSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHQ4</accession>
    <name>B8MHQ4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Ferrooxidoreductase Fet3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TSTA_014760</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cell membrane</location>
            <topology evidence="16">Single-pass type I membrane protein</topology>
            <orientation evidence="16">Extracellular side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483618.1">
        <property type="nucleotide sequence ID" value="XM_002483573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHQ4"/>
    <dbReference type="FunCoup" id="B8MHQ4">
        <property type="interactions" value="745"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MHQ4"/>
    <dbReference type="GeneID" id="8107859"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_014760"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_7_3_1"/>
    <dbReference type="InParanoid" id="B8MHQ4"/>
    <dbReference type="OMA" id="ILHVGTH"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="PhylomeDB" id="B8MHQ4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13851">
        <property type="entry name" value="CuRO_1_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13899">
        <property type="entry name" value="CuRO_3_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000022">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000024">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000025">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0186">Copper</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0410">Iron transport</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 18" id="KW-0732">Signal</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002875181" evidence="18">
        <location>
            <begin position="19"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="564"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="MHD" evidence="19">
        <location>
            <begin position="244"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EED16384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="608" mass="67322" checksum="23E6844B29AECA88" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHV0</accession>
    <name>B8MHV0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_015180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483664.1">
        <property type="nucleotide sequence ID" value="XM_002483619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHV0"/>
    <dbReference type="STRING" id="441959.B8MHV0"/>
    <dbReference type="GeneID" id="8106260"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_015180"/>
    <dbReference type="eggNOG" id="ENOG502RYMZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005679_13_5_1"/>
    <dbReference type="InParanoid" id="B8MHV0"/>
    <dbReference type="OMA" id="GAYEWTR"/>
    <dbReference type="OrthoDB" id="5819582at2759"/>
    <dbReference type="PhylomeDB" id="B8MHV0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF134">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="459"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="3">
        <location>
            <begin position="111"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED16430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="541" mass="62695" checksum="7A25D21A770ECF65" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHY4</accession>
    <name>B8MHY4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_015500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483698.1">
        <property type="nucleotide sequence ID" value="XM_002483653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHY4"/>
    <dbReference type="GeneID" id="8106292"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_015500"/>
    <dbReference type="HOGENOM" id="CLU_1563922_0_0_1"/>
    <dbReference type="InParanoid" id="B8MHY4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="171" mass="19083" checksum="755A426E464CDE6F" modified="2009-03-03" version="1">MSKKAKQATSGANMGENMFGPLLDQALHAAVDKAVKKALNEVLEKTVDQAVKKVVDEAARKVMQEAFKPSYARKLPRLPRSSDEVEEVEETGVTQDESLKTPAQSSIEDDDEDSCESISESEEPSKGSFRPGCEYHTAILIKVGYCALEVRKDHHLFVAEYYPYTESRFNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHY6</accession>
    <name>B8MHY6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD dependent epimerase/dehydratase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_015530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483700.1">
        <property type="nucleotide sequence ID" value="XM_002483655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHY6"/>
    <dbReference type="STRING" id="441959.B8MHY6"/>
    <dbReference type="GeneID" id="8106294"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_015530"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="InParanoid" id="B8MHY6"/>
    <dbReference type="OMA" id="TAFIWQI"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="PhylomeDB" id="B8MHY6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF562">
        <property type="entry name" value="ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED16466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="342" mass="36992" checksum="1A4268919664A66C" modified="2009-03-03" version="1">MASQTELPLVLVTAVNGFIASWTAKVFLDAGYNVRGTTRSAKSAATVLEADPFKEYAASGRFTIFQVPDITLPGAFDDAVRGVHAIAHTASPMPSNSPNPESFIGTAVDGAKSVLESAYSKAGPNLKTPTDAPYTFTEEDWDDFSEKAVELQGKEASPGLIYKASKTAAERAMWDFQREKSPSFTLAAINPVFVWGPPILFPENPEDINSTTMAIWTIFSGQDIPPPPLGRPGGGAVDVRDVARLILFAVQEPEKSSNQRFLAVSGLRVEQAIADILRQEYPDRRTIIKEGTPGVGYLPDFSYPENSSGRVDGSKAVKATGKEWISPKQSIIDAAKAFERYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8MI21</accession>
    <name>B8MI21_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pantothenate transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_022370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484417.1">
        <property type="nucleotide sequence ID" value="XM_002484372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MI21"/>
    <dbReference type="FunCoup" id="B8MI21">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="GeneID" id="8107074"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_022370"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_2_0_1"/>
    <dbReference type="InParanoid" id="B8MI21"/>
    <dbReference type="OMA" id="FRERTFI"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="PhylomeDB" id="B8MI21"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000247">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF29">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="89"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED17183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="549" mass="62309" checksum="098FEA459502234C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8MI37</accession>
    <name>B8MI37_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_022530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484433.1">
        <property type="nucleotide sequence ID" value="XM_002484388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MI37"/>
    <dbReference type="STRING" id="441959.B8MI37"/>
    <dbReference type="GeneID" id="8107090"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_022530"/>
    <dbReference type="eggNOG" id="ENOG502SX1Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076666_1_0_1"/>
    <dbReference type="InParanoid" id="B8MI37"/>
    <dbReference type="OrthoDB" id="4217358at2759"/>
    <dbReference type="PhylomeDB" id="B8MI37"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED17199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="177" mass="21270" checksum="B8BC6C99250EB518" modified="2009-03-03" version="1">MHNTRLPMYIDKKLHHFISEPWWKNTNNEVVQFLHDELPFQWPWGYTIYRTVYTPESNQHWDALLEAISKSIYRSLDEDEPSRIFQEGYRPLAFDDSAQFNGATLDKIRNHFKEVRESDNGHQGVRFRWCLVIDEAALQSIIRHPGWVTVVDPNYQEDSSCNTEYYLGYFRLYLKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIC9</accession>
    <name>B8MIC9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_040920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484566.1">
        <property type="nucleotide sequence ID" value="XM_002484521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIC9"/>
    <dbReference type="STRING" id="441959.B8MIC9"/>
    <dbReference type="GeneID" id="8099900"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_040920"/>
    <dbReference type="eggNOG" id="ENOG502SNEE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009388_3_0_1"/>
    <dbReference type="InParanoid" id="B8MIC9"/>
    <dbReference type="OMA" id="NIRHEEF"/>
    <dbReference type="OrthoDB" id="2426273at2759"/>
    <dbReference type="PhylomeDB" id="B8MIC9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596:SF2">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G17550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="304"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="744" mass="85967" checksum="F25C72253C7063D5" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIT8</accession>
    <name>B8MIT8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_050390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485553.1">
        <property type="nucleotide sequence ID" value="XM_002485508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIT8"/>
    <dbReference type="STRING" id="441959.B8MIT8"/>
    <dbReference type="GeneID" id="8109081"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_050390"/>
    <dbReference type="HOGENOM" id="CLU_2559866_0_0_1"/>
    <dbReference type="InParanoid" id="B8MIT8"/>
    <dbReference type="OrthoDB" id="4227485at2759"/>
    <dbReference type="PhylomeDB" id="B8MIT8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022198">
        <property type="entry name" value="DUF3723"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12520">
        <property type="entry name" value="DUF3723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED15600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="82" mass="9302" checksum="F4459028AA1128AA" modified="2009-03-03" version="1">MRHYLSMSKDPESDDLLAKPANEKADETIVYNMAALAQKLGFTPPAQCLLKARKPDSYEYSTDDFEQSIRRIVEVLHCGHAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJ37</accession>
    <name>B8MJ37_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_051350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485652.1">
        <property type="nucleotide sequence ID" value="XM_002485607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJ37"/>
    <dbReference type="GeneID" id="8106337"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_051350"/>
    <dbReference type="HOGENOM" id="CLU_143030_1_0_1"/>
    <dbReference type="InParanoid" id="B8MJ37"/>
    <dbReference type="OrthoDB" id="4357294at2759"/>
    <dbReference type="PhylomeDB" id="B8MJ37"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED15699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="109" mass="12005" checksum="14F7ED38E683B9A6" modified="2009-03-03" version="1" fragment="single">DIFDMSKWHKSTGIFRSPPLKDPLRPNSLPAVTVHEKRDILVRNLLQNSAEAGDIPLDSPTVPSTSLYFPDISMLQVEESVLQAGNTAPGADEIPTCILKVAWPLIKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJY1</accession>
    <name>B8MJY1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_042730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484751.1">
        <property type="nucleotide sequence ID" value="XM_002484706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJY1"/>
    <dbReference type="STRING" id="441959.B8MJY1"/>
    <dbReference type="GeneID" id="8103365"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_042730"/>
    <dbReference type="eggNOG" id="ENOG502S3ZD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029537_1_0_1"/>
    <dbReference type="InParanoid" id="B8MJY1"/>
    <dbReference type="OMA" id="DYSCKPS"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="PhylomeDB" id="B8MJY1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002918">
        <property type="entry name" value="Lipase_EstA/Esterase_EstB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015">
        <property type="entry name" value="FASTING INDUCED LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015:SF1">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01674">
        <property type="entry name" value="Lipase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877554" description="Lipase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="30555" checksum="403BF35FA3CF2EAE" modified="2009-03-03" version="1">MLFFSVLSLLAATTLVSAILTPDPGNDYSCTSSHNPVITLHGLGATYYEDINFLGDWLKSQGFCVYRATYGAYPAFPLVGGFLPINESAAEIADFIKDVATNTGKSKIDLVGHSEGAFQSLYVPKFEAGISALVQRIVSIAPPTRGTNFANLITLAQDLGIDNLVQDVLHTFGCDACNDLVDGGAAIEQLNDGTPIVQPGNQLTVIISRNDELVTPTSTSPVNEAGVRNEYVQDYCPLDPVGHIGEAYDLNVWNMVKNALTDGTAKNFICVFGSPGKNLRIWMDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8MK11</accession>
    <name>B8MK11_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcriptional elongation factor Iws1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_043020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IWS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484781.1">
        <property type="nucleotide sequence ID" value="XM_002484736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MK11"/>
    <dbReference type="FunCoup" id="B8MK11">
        <property type="interactions" value="355"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MK11"/>
    <dbReference type="GeneID" id="8104946"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_043020"/>
    <dbReference type="eggNOG" id="KOG1793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045275_1_0_1"/>
    <dbReference type="InParanoid" id="B8MK11"/>
    <dbReference type="OMA" id="MPAYNIQ"/>
    <dbReference type="OrthoDB" id="21124at2759"/>
    <dbReference type="PhylomeDB" id="B8MK11"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.10:FF:000003">
        <property type="entry name" value="Putative Transcription factor IWS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="8">
        <location>
            <begin position="242"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="388"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED14828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="417" mass="47737" checksum="771A611E348431CE" modified="2009-03-03" version="1">MSASPEPQADSPAADPDRAELQAELDDLNDNNGGATEENPEISDDESVLSEVDEAQFEDFNPDDVAIEDRPALDVDAENLKLIGRHKRKRRDDEEGEPKRKREGRREKRKRAQRDSDVESGDAKAGRRKAAKSRREATPEDEETLSPEERRRRALDRAMDAAMKQKTRRRRKADGIDLEQMADAEIEDMRRRMTDAARLDAEARRQGQPAMHKLKMLPEVLNLLNRNQYTASLVDPEINLLEAVKFFLEPLDDGELPAYNIQRDLMDVLGKLPINKDSLVASGIGKVIVFYTKSKRPELKIKRQAERLLADWTRPILQRSDDYSKRVYEEVEFDPTRLVNRANIAQQTAEEARARELLPPRLANRARREMGHTSYSIVPRSTVIQDNKFARPVGASGEDRFRRMKARQLNAGKPSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKA7</accession>
    <name>B8MKA7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_047130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485215.1">
        <property type="nucleotide sequence ID" value="XM_002485170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKA7"/>
    <dbReference type="STRING" id="441959.B8MKA7"/>
    <dbReference type="GeneID" id="8098506"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_047130"/>
    <dbReference type="eggNOG" id="ENOG502QTQ8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044876_1_1_1"/>
    <dbReference type="InParanoid" id="B8MKA7"/>
    <dbReference type="OMA" id="TLAAHHW"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="PhylomeDB" id="B8MKA7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF7">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="19"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED15262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="341" mass="37614" checksum="1A5E6AC0B8C31259" modified="2009-03-03" version="1">MAIGYAKDQPTGFKNYLENIAIVGAGGQVGKFIVQALVANGKHKITALTREGSTNTVPAGVHSIQKIDYSQPSTIVEALKGQDALICTLSIRATDEAEKLSRAAAEAGVKWILPNEFGNSKNNEQIDRDIMIGVVKAKDRKLIEELGVSSWIGVATGFWYEYSLSVGPWSYGFDIKNRAVTFFDDGAKQINTTTWPQVGRGVANLLGLKVLPDDENDKSPHLSQFKNDFVCISSFKVSQQQIFESLLRVTGTSRDDWKVTTESAKERYEKGKVMLEAGDRTGFGLLLYSRVFYPDEAGQHPRVDNAALGLPEENLDEWTAVAVKMAKEDYFLKHVVPRTMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKK8</accession>
    <name>B8MKK8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_048070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485316.1">
        <property type="nucleotide sequence ID" value="XM_002485271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKK8"/>
    <dbReference type="STRING" id="441959.B8MKK8"/>
    <dbReference type="GeneID" id="8106989"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_048070"/>
    <dbReference type="eggNOG" id="ENOG502RVQB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_585225_0_0_1"/>
    <dbReference type="InParanoid" id="B8MKK8"/>
    <dbReference type="OMA" id="GENTHFA"/>
    <dbReference type="OrthoDB" id="5402033at2759"/>
    <dbReference type="PhylomeDB" id="B8MKK8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED15363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="52152" checksum="8135FC2EC160269E" modified="2009-03-03" version="1">MPDPMQLPHELRLMIMNHATDEVDRMLCNMSLVSKRWHAILIEQIYSCWQQYAYNRNPISSMWKFLRTILSNRQIADTVREIRYSSFELSGGRYSHSSKRPTLSRGDYDMIQKAICRAGLDHLKPYVIEAINNADPRPLLALLLANLRNLQTLHACLPDSDVILAEVFREAVKCKQNLRNGFSPLHNLREVYLDGMPWVCNECKRSHHIHVTLLWPIFQLPAIHRVSVSNFKPHEGASRAKYSKDFGYVFEASTVTDLNLAVDTSSNPCLGTPDSFILFALPKRLARLSVYLKGYNSTISNTDIWNAIQPYEGSIEYLDIDRHDHCRETDNSKLGSMRGFKRLERLYIQPRLLNDKDSLGDTLPPNCQSLNFYFDGRFSFSKTFIQQLQDFIPSTHLHVPNLWHIVLDRSGYLISRDFLLYDQMEDSCTKYGIKFEAKLLSKYGKGPRHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8ML80</accession>
    <name>B8ML80_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucoamylase</fullName>
            <ecNumber evidence="9">3.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan glucohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glucan 1,4-alpha-glucosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_044610</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Hydrolysis of terminal (1-&gt;4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 15 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.3" evidence="9"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484948.1">
        <property type="nucleotide sequence ID" value="XM_002484903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ML80"/>
    <dbReference type="FunCoup" id="B8ML80">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8ML80"/>
    <dbReference type="GeneID" id="8104137"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_044610"/>
    <dbReference type="eggNOG" id="ENOG502QPM2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012173_1_0_1"/>
    <dbReference type="InParanoid" id="B8ML80"/>
    <dbReference type="OMA" id="MAPRFWT"/>
    <dbReference type="OrthoDB" id="6123450at2759"/>
    <dbReference type="PhylomeDB" id="B8ML80"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004339">
        <property type="term" value="F:glucan 1,4-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GLHYDRLASE15"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00820">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877575" description="Glucoamylase" evidence="13">
        <location>
            <begin position="21"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="14">
        <location>
            <begin position="530"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
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        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="208"/>
        </location>
    </feature>
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        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001863"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
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        <source>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001031-1"/>
        </source>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001031-2"/>
        </source>
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    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED14995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="637" mass="67504" checksum="CE080766E925D141" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLE9</accession>
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        </recommendedName>
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        <dbReference type="NCBI Taxonomy" id="441959"/>
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            <taxon>Eurotiomycetidae</taxon>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_049210"/>
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    <dbReference type="Proteomes" id="UP000001745">
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    </dbReference>
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        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
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        <property type="entry name" value="RNaseH-like_sf"/>
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    </dbReference>
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            <end position="997"/>
        </location>
    </feature>
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            <end position="566"/>
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        <location>
            <begin position="1111"/>
            <end position="1158"/>
        </location>
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        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
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        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1140"/>
            <end position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED15482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1717" mass="194090" checksum="1DBD970CA6383949" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLL8</accession>
    <name>B8MLL8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_049890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485504.1">
        <property type="nucleotide sequence ID" value="XM_002485459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLL8"/>
    <dbReference type="GeneID" id="8108753"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_049890"/>
    <dbReference type="HOGENOM" id="CLU_046030_0_0_1"/>
    <dbReference type="InParanoid" id="B8MLL8"/>
    <dbReference type="OMA" id="WQLHTDE"/>
    <dbReference type="OrthoDB" id="1421156at2759"/>
    <dbReference type="PhylomeDB" id="B8MLL8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="355" mass="40740" checksum="CF71D36A42B3C564" modified="2009-03-03" version="1">MRARDFMKLVNAYTEEEKDAEWNNFRAKYSHNVWDTVFEYIKKEWLQEDMAKHFLKCYTNEYLHLNKQASSQVEGAHWIIKRDLGTSTMDLLRATLSIEMTIEKQHQKIWQEIEDERVQIKIDFKNLRLFKHVLKKVSSHALKIIHSIFERYLPESAPDKKPIKPCTGVTRRTLGIPCIHKIKEYYEADTSIELFEFCPHWQLHTDEDLPPMDPRELVLELEVIRPRGRPPGAINWPTTSEQSQSAEDRSTRRDPSAFEHLLTQESSRGRGSGHVRGSCGGGQARSGRGARQRGRGSHGEGQAGRGRGGRQQGGECGSGSAGTSEVSTQSHENDDNEISENRDDKTNENQIRRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLQ9</accession>
    <name>B8MLQ9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_098870</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485869.1">
        <property type="nucleotide sequence ID" value="XM_002485824.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485870.1">
        <property type="nucleotide sequence ID" value="XM_002485825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLQ9"/>
    <dbReference type="FunCoup" id="B8MLQ9">
        <property type="interactions" value="698"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MLQ9"/>
    <dbReference type="GeneID" id="8099715"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_098870"/>
    <dbReference type="eggNOG" id="KOG1443">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022332_1_1_1"/>
    <dbReference type="InParanoid" id="B8MLQ9"/>
    <dbReference type="OMA" id="AHLMGDQ"/>
    <dbReference type="OrthoDB" id="18894at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="10">
        <location>
            <begin position="66"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED13631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="410" mass="44500" checksum="E002F56E23EE6B01" modified="2009-03-03" version="1">MTDTYEISIFDSSDDDISLAAAEEVGLLASQQSHRRTSSIDHFVTYTRRTVSDLLSDLDFIHNALSIALLAVLWHMFSLAISVYNKWMFSGDIISFPFPLFMTSLHQAVQFCLSALFLYLVPSLRPQRNNTNNSTLPSPAVLPGADLQKGGSMSIKRLYLIHLIPGGVATALDMGLGNMSLRFSSLTFMTACKSSTLVFILLFAFLFGLERPSARLALIIAVMTAGEVMMVLGEVTFSLPGFALVTGSAFFSGFRWALSQLLILKHPATSNPVSMLFHLSPVVFITLIGISISVEDPNEIIDALYALSETCGSSATAISLLLLPGCLAFCMVLSQFALLQRSSVVTLSVCGILKEVVIIGVAGMVFGDKLTSVNICGVVAIMASVIAYNYMKIKAARKPVREKWVGEKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>B8MM59</accession>
    <name>B8MM59_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Polyketide synthase, putative</fullName>
            <ecNumber evidence="14">2.3.1.161</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_098280</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.161" evidence="14"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485809.1">
        <property type="nucleotide sequence ID" value="XM_002485764.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MM59"/>
    <dbReference type="GeneID" id="8108467"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_098280"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_31_5_1"/>
    <dbReference type="InParanoid" id="B8MM59"/>
    <dbReference type="OMA" id="RNWIGAY"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="PhylomeDB" id="B8MM59"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050637">
        <property type="term" value="F:lovastatin nonaketide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="12">
        <location>
            <begin position="32"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="13">
        <location>
            <begin position="962"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="2445"/>
            <end position="2522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="9">
        <location>
            <begin position="962"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="9">
        <location>
            <begin position="1119"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="9">
        <location>
            <position position="994"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="9">
        <location>
            <position position="1180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED13571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="2528" mass="277252" checksum="8DCF94EDE275D67B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8MML4</accession>
    <name>B8MML4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier protein (Rim2), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_100130</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486005.1">
        <property type="nucleotide sequence ID" value="XM_002485960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MML4"/>
    <dbReference type="FunCoup" id="B8MML4">
        <property type="interactions" value="445"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MML4"/>
    <dbReference type="GeneID" id="8105456"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_100130"/>
    <dbReference type="eggNOG" id="KOG0757">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_6_0_1"/>
    <dbReference type="InParanoid" id="B8MML4"/>
    <dbReference type="OMA" id="WVMYEQM"/>
    <dbReference type="OrthoDB" id="269120at2759"/>
    <dbReference type="PhylomeDB" id="B8MML4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF4">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="45"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="170"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="285"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED13767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="384" mass="41784" checksum="2340B2CF8BE061BC" modified="2009-03-03" version="1">MTFSTTSHGSSAQAHLPNKVHLGEEATESREMGVAIPQKDDTLKAKPLAHFIAGGVGGMTAATLTSPLDVLKTRLQSDFYQSQLQALRASHPVRPAPLFISLPRSALVHFKETFQILHSIYSHEGPRALFKGLGPNLVGVVPARAINFYVYGNGKRILSNYFGYHDSMTTPWNIHLGAAAIAGIATGTATNPIWLIKTRLQLDKSNAESGKGGRQYKNSWDCIKQTVRHEGIRGLYKGLSASYLGVAESATQWVLYEQMKLYLARREAAKLADPKHVHTTWDDVELWGGRIAAAGAAKLFAAVATYPHEVVRTRLRQAPVVPVAGGKVQVKYTGLIQCFKVVAKEEGLAGLYGGLTPHLLRVVPSAAIMFGMYEVILRLFGTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMQ3</accession>
    <name>B8MMQ3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_098770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485858.1">
        <property type="nucleotide sequence ID" value="XM_002485813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMQ3"/>
    <dbReference type="STRING" id="441959.B8MMQ3"/>
    <dbReference type="GeneID" id="8099705"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_098770"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_4_1"/>
    <dbReference type="InParanoid" id="B8MMQ3"/>
    <dbReference type="OMA" id="CPGFCQS"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="PhylomeDB" id="B8MMQ3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF22">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE PHMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="387" mass="42694" checksum="B15287CDAD7A7933" modified="2009-03-03" version="1">MSTITRIRPQSLVNNALKQTKPTLDAHRYQGGNFHAYMTSKLSTYDTERSYSLFQKTLQDPLRTSPSSLAGKSILVTGSNTGLGFEAALKSVDLGAKHVILGVRNVEKGEHAKQRILQRATSMKAQPSDTTKDGNPDDQTISVRKLDMSDYNSIHSFVKEVGKKDGRLDVAILNAGVFGVKYETAGNYGWENDLQVNVLSTALLSLLLLQAKIIKPEVGVLEFVASRRMQAVQLTEEEKKSHNLLETFNRKQNFNASRQYQVSKLLLMAFYQSLASRSAKLTEGSPIITAVCPGFCQSDLSRGHQGFAADVLRAVLNTFVLRRAEEGARTLVSGALGTKERHGKFWFDDGLHDIALPDSVGDAQGFADRIWEEVVHALQRDTNAPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMR1</accession>
    <name>B8MMR1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_100610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486055.1">
        <property type="nucleotide sequence ID" value="XM_002486010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMR1"/>
    <dbReference type="GeneID" id="8097945"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_100610"/>
    <dbReference type="HOGENOM" id="CLU_2943401_0_0_1"/>
    <dbReference type="InParanoid" id="B8MMR1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED13817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="60" mass="6742" checksum="763AAE3667B80EFB" modified="2009-03-03" version="1">MPFQSSDNIPIRYFNWNSVVASIMVHEAIHYPDLPQSMANAEDCSGEAKIPEDPFSRNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMW6</accession>
    <name>B8MMW6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein CMS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_101550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486153.1">
        <property type="nucleotide sequence ID" value="XM_002486108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMW6"/>
    <dbReference type="FunCoup" id="B8MMW6">
        <property type="interactions" value="287"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MMW6"/>
    <dbReference type="GeneID" id="8101843"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_101550"/>
    <dbReference type="eggNOG" id="KOG3089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057568_0_0_1"/>
    <dbReference type="InParanoid" id="B8MMW6"/>
    <dbReference type="OMA" id="DHFAQKA"/>
    <dbReference type="OrthoDB" id="1929311at2759"/>
    <dbReference type="PhylomeDB" id="B8MMW6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032704">
        <property type="entry name" value="Cms1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030:SF0">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14617">
        <property type="entry name" value="CMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="32598" checksum="883CD5397D090BE8" modified="2009-03-03" version="1">MADTQSSKGPSSTKGQDKKRKREDGHRTAQNSKMQKRWSKDKKFNKNNNKEKDKKGNGNKDDNKQLNQTAQQPEREEAIDESISKMNEQILADHFMQKAKAHNKDLTAVELNDMSVPVHAFQDTSSFEQERKLTQLPDFLKTYSPEKGARLGSASEEKGSPHTLVIAPAGLRAADLVRALRSFQTKDAAVAKLFAKHIKIEEAKQFLERSRVSIGVGTPQRIIDLLESGTLKTANLERIVIDGSHIDQKKRSIFDMKEVYAPLLKLLAREELKERYGAKDKDLKILVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8MN90</accession>
    <name>B8MN90_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_107460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486777.1">
        <property type="nucleotide sequence ID" value="XM_002486732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MN90"/>
    <dbReference type="GeneID" id="8106775"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_107460"/>
    <dbReference type="HOGENOM" id="CLU_1636549_0_0_1"/>
    <dbReference type="InParanoid" id="B8MN90"/>
    <dbReference type="PhylomeDB" id="B8MN90"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036082">
        <property type="entry name" value="NSP3_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69903">
        <property type="entry name" value="NSP3 homodimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="162" mass="18967" checksum="79AD2E5D551D6EE3" modified="2009-03-03" version="1">MADKNAILSDNSQDDTSEYQYQDPSPGDRGVSSGSYQTVPEINFPDDRWITEIRFNNETGRNALYYAACNQYVDYEIFMWLLDYFGNWTHDDFKRLSVHIQKKIKDMLMDRGIFVDYIGRKKTIAKALDDLVQMTRMPEWPHEIAAARTFDSRLKMAKGQFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNF7</accession>
    <name>B8MNF7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">glutaryl-CoA dehydrogenase (ETF)</fullName>
            <ecNumber evidence="11">1.3.8.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSTA_102760</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>glutaryl-CoA + oxidized [electron-transfer flavoprotein] + 2 H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13389"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid metabolism; lysine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid metabolism; tryptophan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.6" evidence="11"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486284.1">
        <property type="nucleotide sequence ID" value="XM_002486239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNF7"/>
    <dbReference type="STRING" id="441959.B8MNF7"/>
    <dbReference type="GeneID" id="8101110"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_102760"/>
    <dbReference type="eggNOG" id="KOG0138">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_8_0_1"/>
    <dbReference type="InParanoid" id="B8MNF7"/>
    <dbReference type="OMA" id="HMMNLES"/>
    <dbReference type="OrthoDB" id="435240at2759"/>
    <dbReference type="PhylomeDB" id="B8MNF7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004361">
        <property type="term" value="F:glutaryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01151">
        <property type="entry name" value="GCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000003">
        <property type="entry name" value="glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000006">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000008">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052033">
        <property type="entry name" value="Glutaryl-CoA_DH_mitochondrial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807:SF1">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="16">
        <location>
            <begin position="46"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="15">
        <location>
            <begin position="161"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="14">
        <location>
            <begin position="278"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EED14046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="426" mass="46722" checksum="552F99E479431B83" modified="2009-03-03" version="1">MSRSLFRSAARQLRASTLPRHQTRRWASSTATFNWEDPLAASELYTEEELAIQDTARQYCQERLMPRVLEAYRNENYDRKILEEMGEIGLLGASIEGYECAGASTVASGLITKEVERVDSGYRSGMSVQSSLIMTGIHEFGTQEQKDRFLPQLAKGKLLGCFGLTEPNHGSDPGSMETVAREHPTKKGYYSLSGAKTWITNSPISDVLLVWAKLESTGKIKGFLIERSKCPPGTLETPAIKNKTALRASITGMIQMDNCPVPEENMLPTVEGLSGPFTCLNSARLGIAFGVTGALEDALSRAREYSLDRKQFKGNPLAKYQLIQKKLADAATDAAFGTLAAIQVARLKDAGKSTPEMISMIKRQNCDRALANARTLQEIFGGNATSDEYHIGRHVANLFVTQTYEGQSDIHALILGRAITGIQAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MP47</accession>
    <name>B8MP47_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MGMT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_104990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486524.1">
        <property type="nucleotide sequence ID" value="XM_002486479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MP47"/>
    <dbReference type="STRING" id="441959.B8MP47"/>
    <dbReference type="GeneID" id="8098720"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_104990"/>
    <dbReference type="eggNOG" id="KOG4062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_52_5_1"/>
    <dbReference type="InParanoid" id="B8MP47"/>
    <dbReference type="OMA" id="DEAEWWF"/>
    <dbReference type="OrthoDB" id="2548197at2759"/>
    <dbReference type="PhylomeDB" id="B8MP47"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052520">
        <property type="entry name" value="ATL_DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942">
        <property type="entry name" value="6-O-METHYLGUANINE DNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942:SF1">
        <property type="entry name" value="ALKYLTRANSFERASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="3">
        <location>
            <begin position="11"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED14286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="165" mass="18544" checksum="1D16175BDFD73E74" modified="2009-03-03" version="1">MPRTDEAEHWFNAVYEAVQEIPLGCVTTYGHIARLLGYPRRARQVGICLKHLPSNRTNRTSSAKGGGDESAEEDENDEQGEIYHHFHDDNVPWQRVVNSKGTISHRGPGSASRQAVALRHEGVTVEQDAMGDFYIDMARYGWFPARLPSEEGESEDSDSLEEEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPW5</accession>
    <name>B8MPW5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSTA_053690</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486966.1">
        <property type="nucleotide sequence ID" value="XM_002486921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPW5"/>
    <dbReference type="FunCoup" id="B8MPW5">
        <property type="interactions" value="218"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MPW5"/>
    <dbReference type="GeneID" id="8098320"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_053690"/>
    <dbReference type="eggNOG" id="KOG0752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_10_0_1"/>
    <dbReference type="InParanoid" id="B8MPW5"/>
    <dbReference type="OMA" id="VYERMKW"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="PhylomeDB" id="B8MPW5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002167">
        <property type="entry name" value="GDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00928">
        <property type="entry name" value="GRAVESDC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="54"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="153"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="306"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EED12855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="397" mass="43258" checksum="9BDE1AA424634ED1" modified="2009-03-03" version="1">MEVSRQASTLRSSGMSDNPEDATAPVAADRVLSKERTDNSTVTDVKPVDKRSLDYVLRSGLAGGLAGCAGKTVVAPLDRVKILFQASNPQFAKYSGSWSGLALAMRDIHKYEGSRGLFKGHSATLLRIFPYAAIKFLAYEQIRAVIIPSREKETPFRRLISGSLAGVTSVFFTYPLEVVRVRMAFETKRNARSSYTAICKQIYHEQASSRPVAASAGPNQSATMATAQTVSTSINAVTPRSGLANFYRGFAPTILGMIPYAGISFLTHDTVGDILRLPGLAQYTTIPDSDAPRKSGKRQGKRRLQLTASAELFSGAAAGLVSQTSAYPLEVIRRRMQVGGATGDGHRLSIAETARKIFLERGFRGFWVGLTIGYLKIIPMSATSFFVYERMKWYLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPY5</accession>
    <name>B8MPY5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Microtubule associated protein (Ase1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_053880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486986.1">
        <property type="nucleotide sequence ID" value="XM_002486941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPY5"/>
    <dbReference type="FunCoup" id="B8MPY5">
        <property type="interactions" value="162"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MPY5"/>
    <dbReference type="GeneID" id="8100328"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_053880"/>
    <dbReference type="eggNOG" id="KOG4302">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013892_0_0_1"/>
    <dbReference type="InParanoid" id="B8MPY5"/>
    <dbReference type="OMA" id="QLHGIYD"/>
    <dbReference type="OrthoDB" id="642895at2759"/>
    <dbReference type="PhylomeDB" id="B8MPY5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF41">
        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="460"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="618"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="638"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED12875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="773" mass="87730" checksum="A6897E670704F52D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQ21</accession>
    <name>B8MQ21_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ferrochelatase</fullName>
            <ecNumber evidence="12">4.98.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_054230</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>heme b + 2 H(+) = protoporphyrin IX + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.98.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ferrochelatase family.</text>
    </comment>
    <dbReference type="EC" id="4.98.1.1" evidence="12"/>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487022.1">
        <property type="nucleotide sequence ID" value="XM_002486977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQ21"/>
    <dbReference type="FunCoup" id="B8MQ21">
        <property type="interactions" value="710"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MQ21"/>
    <dbReference type="GeneID" id="8100362"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_054230"/>
    <dbReference type="eggNOG" id="KOG1321">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018884_1_1_1"/>
    <dbReference type="InParanoid" id="B8MQ21"/>
    <dbReference type="OMA" id="DPYHCEC"/>
    <dbReference type="OrthoDB" id="1323at2759"/>
    <dbReference type="PhylomeDB" id="B8MQ21"/>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1400:FF:000003">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED12911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="422" mass="46666" checksum="97A938DBFF0CCBA6" modified="2009-03-03" version="1">MMAVRTSLSLPCRMIPNNISHNVRPATQLVKRPLNGHGFATATSVPKKGSKGPTAMVLLNMGGPSKVAEVEDFLSRLFADADLIPLGPLQKYLGPLIARRRTPKIQKQYSEIGGGSPIRKWSEYQCAEMCKILDEISPETAPHKPYVAFRYADPLTENMYKQLLEDGFGGGNGGRAVAFTQYPQYSCSTTGSSLNELWKWRNRLEGPRSGQDGDGAIQWSVIDRWATHPGLVEAFAKNIEDQLATYPEEKRSSVVILFSAHSLPMSVVNRGDPYTAEVATTVHAVMQRLGFSNPYRLCWQSQVGPSAWQGAQTSHTVENYVKKGFTDMILVPIAFTSDHIETLYELDKEVIGEAGHTGIKRAESLNGNPTFIRALADIAKNHLQSGEKCSRQMTLRCQGCNSERCLEQKKFFAGDALKSLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQA2</accession>
    <name>B8MQA2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_057400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487360.1">
        <property type="nucleotide sequence ID" value="XM_002487315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQA2"/>
    <dbReference type="STRING" id="441959.B8MQA2"/>
    <dbReference type="GeneID" id="8108876"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_057400"/>
    <dbReference type="HOGENOM" id="CLU_744291_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQA2"/>
    <dbReference type="OMA" id="HIWRVIY"/>
    <dbReference type="OrthoDB" id="4363438at2759"/>
    <dbReference type="PhylomeDB" id="B8MQA2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="372" mass="43787" checksum="1C04DF940CC0F425" modified="2009-03-03" version="1">MDTKKNIVILKTTDDWRKWIEQLSTEAMKENVWEYINPDPNRMVLEPAPAKPMEPVAPEIDFNKTSEAQLLLQKYQIESNTYERQLSRFEKHQKRMKHIHSYILDTVYIGHKPMIREISEVSEIIRELKKKLAPKPNREKIKRINSEMRDLIIDMRFAKFTEIPDDRLARDFIKTTEDILTKFYETWTTRMIEFDLDSGATSLIEAPTVDEIISQFERWEEVYAKSNETSRRDIAMATFGNKSDQPEKDQKDLTTPKQKPTCVCGQEHLFEDCPYVNTKKRTANWKPDGAIQRKFEQLERRHGHPRARMLQRIKKKLEKEGKSETKASSSTDAMNDSANQSQFIPHPDCTLLSEPNPVRTSTKRFQYWGDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQJ3</accession>
    <name>B8MQJ3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_058830</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 10">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the eukaryotic ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487506.1">
        <property type="nucleotide sequence ID" value="XM_002487461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQJ3"/>
    <dbReference type="FunCoup" id="B8MQJ3">
        <property type="interactions" value="474"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MQJ3"/>
    <dbReference type="GeneID" id="8106485"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_058830"/>
    <dbReference type="eggNOG" id="KOG3976">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077208_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQJ3"/>
    <dbReference type="OMA" id="YTEWADG"/>
    <dbReference type="OrthoDB" id="67388at2759"/>
    <dbReference type="PhylomeDB" id="B8MQJ3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2210:FF:000002">
        <property type="entry name" value="ATP synthase subunit 4 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008688">
        <property type="entry name" value="ATP_synth_Bsub_B/MI25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013837">
        <property type="entry name" value="ATP_synth_F0_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733:SF3">
        <property type="entry name" value="ATP SYNTHASE F(0) COMPLEX SUBUNIT B1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE B CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05405">
        <property type="entry name" value="Mt_ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161060">
        <property type="entry name" value="ATP synthase B chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0138">CF(0)</keyword>
    <keyword evidence="4 10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED13395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="277" mass="30241" checksum="6731CD962AD7653C" modified="2009-03-03" version="1">MPITASIFLQTPSRQLLVTSGFPNTANPAASHCTTMASRLAKSAIGATRVRPALVTRNLPSITANITAPRYASNVPAEEPQKKAQSIIDSLPGNSLVSKTAILSAGAGLSIAAISNELYVLNEETVIAFCLLSVFTALGKYGGPMYREWAEGQSQKYKDILNSARADHTNAVKARIENVQQLGGVVEVTKQLFEVSKETAKLEAQAYELEQRTALAAEAKQVLDSWVRYEGQVKQREQRELAETVIRKIHEELKNPKVLQQILQQSIADVERIVATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQP1</accession>
    <name>B8MQP1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin cytoskeleton organization protein App1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_059510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487575.1">
        <property type="nucleotide sequence ID" value="XM_002487530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQP1"/>
    <dbReference type="STRING" id="441959.B8MQP1"/>
    <dbReference type="GeneID" id="8107420"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_059510"/>
    <dbReference type="eggNOG" id="ENOG502QT5E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008292_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQP1"/>
    <dbReference type="OMA" id="RGPMTRK"/>
    <dbReference type="OrthoDB" id="2117591at2759"/>
    <dbReference type="PhylomeDB" id="B8MQP1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017210">
        <property type="entry name" value="APP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF3">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037464">
        <property type="entry name" value="UCP037464_APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="2">
        <location>
            <begin position="305"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED13464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="787" mass="88396" checksum="9413C47D4ADCBA7A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B8MR72</accession>
    <name>B8MR72_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_054770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487078.1">
        <property type="nucleotide sequence ID" value="XM_002487033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MR72"/>
    <dbReference type="GeneID" id="8100484"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_054770"/>
    <dbReference type="HOGENOM" id="CLU_2335064_0_0_1"/>
    <dbReference type="InParanoid" id="B8MR72"/>
    <dbReference type="OrthoDB" id="5215882at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED12967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="98" mass="11259" checksum="9098935EB6CF3AEE" modified="2009-03-03" version="1">MDTDHYLLGSHYFFVESSGRFVEVDGIRVGSLQLNTLSAVGLLKLKLSSWASTTRRKGPKRNGDMTELEDDEAEGLREWVKEFQDLKQWQELDSSYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8MR89</accession>
    <name>B8MR89_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1993 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_054930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
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    <dbReference type="OMA" id="GKRDYYV"/>
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    <dbReference type="PhylomeDB" id="B8MR89"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="dinb family like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BLL2446 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DinB/YfiT-like putative metalloenzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED12984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="19004" checksum="CFD518211689B963" modified="2009-03-03" version="1">MGILNTLTHVLHTAEQQPNADYLLTNARLYPDMYPVSDQVRLATQFSENIVARLTNREPVNFDHDLGSYSKCYERIETVLKSVKEADKKTVNALGDSVSPTPMGPGKPVDMSEATYAHIIALPNIYFHLTTAYGILRKEGVPLGKMDYYAGFAPIAIHESEVLGKTKSAESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRJ2</accession>
    <name>B8MRJ2_TALSN</name>
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        <submittedName>
            <fullName evidence="4">Conserved leucine-rich repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_056280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002487195.1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_056280"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002093_1_0_1"/>
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    <dbReference type="PhylomeDB" id="B8MRJ2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:septation initiation signaling"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CDIRP"/>
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        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
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        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
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        <property type="entry name" value="LRR_dom_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566:SF1">
        <property type="entry name" value="PROTEIN NUD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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        </location>
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        </location>
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            <end position="726"/>
        </location>
    </feature>
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        <location>
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            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="851"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="968"/>
            <end position="1013"/>
        </location>
    </feature>
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        <location>
            <begin position="1033"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1085"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="80"/>
            <end position="115"/>
        </location>
    </feature>
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        <location>
            <begin position="135"/>
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        </location>
    </feature>
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        <location>
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            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
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            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
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            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
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            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="610"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="626"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="749"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1041"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1085"/>
            <end position="1100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED13129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1758" mass="195101" checksum="730AC0D6FA40C03C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRN5</accession>
    <name>B8MRN5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="7">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_056890</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="7"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002487258.1"/>
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    <dbReference type="AlphaFoldDB" id="B8MRN5"/>
    <dbReference type="FunCoup" id="B8MRN5">
        <property type="interactions" value="259"/>
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    <dbReference type="STRING" id="441959.B8MRN5"/>
    <dbReference type="GeneID" id="8109920"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_056890"/>
    <dbReference type="eggNOG" id="KOG2381">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_009049_2_0_1"/>
    <dbReference type="InParanoid" id="B8MRN5"/>
    <dbReference type="OMA" id="NWMVKVD"/>
    <dbReference type="OrthoDB" id="3349449at2759"/>
    <dbReference type="PhylomeDB" id="B8MRN5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="173"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="311"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="642"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="653"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="690"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="715"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED13192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="790" mass="90271" checksum="F97CFB288DB86E48" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRN8</accession>
    <name>B8MRN8_TALSN</name>
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        <submittedName>
            <fullName evidence="9">Membrane protein TMS1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_056920</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EED13195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="GeneID" id="8109923"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_056920"/>
    <dbReference type="eggNOG" id="KOG2592">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029574_2_0_1"/>
    <dbReference type="InParanoid" id="B8MRN8"/>
    <dbReference type="OMA" id="DKHCNPL"/>
    <dbReference type="OrthoDB" id="5963193at2759"/>
    <dbReference type="PhylomeDB" id="B8MRN8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877671" evidence="8">
        <location>
            <begin position="17"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="384"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED13195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="478" mass="52753" checksum="05E17DC02D38F5DF" modified="2009-03-03" version="1">MGALLSIPMLVLPGAGTIFSVAASCCGAATCSAVCSACGKFQSSIATRIAYAFILLINSIVSWIMLTPWALEKLEHLTMDYMKIRCDGKECHGWVAVHRINFGLGLFHLLLALLLLGVRSSKDGRAMLQNGFWGPKVLLWIGFVVMSFFIPESFFFVYGHYIAFISAMLFLLLGLILLVDLAHSWAELCLEKIEDSDSRLWRGLLIGSTLGMYLISFVMTILMYVFFAKSGCSMNQAAITVNLIVFLIISFVSIQPAIQEYNSRAGLAQAAMVTVYCTYLTMSAVSMEPDDRQCNPLLRARGTRTASVVLGAIVTMATIAYTTTRAATQGIALGSKGGHNYSALSTEANEHGLVTQQPSTRREMRIEALRAAVENGSLPASALDESDDEDDDDYDTKDDERGSTQYNYSLFHVIFFLATTWVATLLTQQLDPETEGNFASVGRTYWASWVKIISAWVCYAIYLWTLIAPAMMPDRFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MS43</accession>
    <name>B8MS43_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Imidazoleglycerol-phosphate dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_004880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="4"/>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488102.1">
        <property type="nucleotide sequence ID" value="XM_002488057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MS43"/>
    <dbReference type="FunCoup" id="B8MS43">
        <property type="interactions" value="242"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MS43"/>
    <dbReference type="GeneID" id="8104472"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_004880"/>
    <dbReference type="eggNOG" id="KOG3143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044308_3_0_1"/>
    <dbReference type="InParanoid" id="B8MS43"/>
    <dbReference type="OMA" id="GIPFFDH"/>
    <dbReference type="OrthoDB" id="447729at2759"/>
    <dbReference type="PhylomeDB" id="B8MS43"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000005">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000001">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="entry name" value="Imidazole glycerol phosphate dehydratase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133:SF2">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE HIS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED12448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="244" mass="26034" checksum="745363C558468348" modified="2009-03-03" version="1">MALPRRTVSISRITNETKIQVSLSLDGGVLLPYEESDHFPCPETAQDKAAVAKGVIPDKNAPHSTQFTSSQQITINTGIGFLDHMLHALAKHSGWSLAIRAKGDLYIDDHHTTEDTMLALGTAFTKALGARTSLARFGRGDAPLDEALSWAVIDLSNRPYAVIDLGFKREKIGDLSTEMITHGLESFAQAAGVTLHVGCSYGSNDHHRAESAFKALAVAIRTACARRTAGEVGAGDVVSTKGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSY6</accession>
    <name>B8MSY6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter of unkown specificity</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_002090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487796.1">
        <property type="nucleotide sequence ID" value="XM_002487751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSY6"/>
    <dbReference type="FunCoup" id="B8MSY6">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="GeneID" id="8098800"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_002090"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_27_4_1"/>
    <dbReference type="InParanoid" id="B8MSY6"/>
    <dbReference type="OMA" id="PMWFFLN"/>
    <dbReference type="OrthoDB" id="2428527at2759"/>
    <dbReference type="PhylomeDB" id="B8MSY6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17476">
        <property type="entry name" value="MFS_Amf1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF41">
        <property type="entry name" value="MFS TRANSPORTER OF UNKOWN SPECIFICITY (AFU_ORTHOLOGUE AFUA_5G09940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="37"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED12142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="508" mass="54537" checksum="63F274FD7DB28338" modified="2009-03-03" version="1">MSESSKSDDPVLEAQLSRTESMRAVAHSFSPIHEFVFVAVVCMAQFMTQAALSVCLSPLDIIGKSFDITNPGILSWLIAGYSLTVGTFILFFGRCGDLFGYRLMLLIGFSWFSLWSLVAGVSVYSNYILFIFARTLQGLGPAMLFPNALAILGATYPPGNKKRLVFSLFGGMAPGGAVVGSVFAALLAELAWWPWAFWCMAIYCLLLAGVVYLVVPPTPSHTADMGLPEILSELDLVGAALGVTGLILVNIAWNQGPVVGWQKAYVYILLIVGFLFLAAFIYYEISVSPHPLIPFETLNTDVCFILGCVACGWSSFGIWVFYTWRFLEDIRGSTPLLAAAQFVPPAPSGLMASFATAYLMGKLKPGWIMLIALSAFTIGSIFMAISPVSQTYWGLTFVSVLVMPWGMDMSFPAATVILSDAVGRRNQGVAASLVTTVVNYSISIGLGIAGTVEVHRNHGGLTFDDRLKGYHAAQYTGIGIGGLGIVLSLLAISHSQIGIIGDGKLAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8MT40</accession>
    <name>B8MT40_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleolin protein Nsr1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_003060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487897.1">
        <property type="nucleotide sequence ID" value="XM_002487852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MT40"/>
    <dbReference type="STRING" id="441959.B8MT40"/>
    <dbReference type="GeneID" id="8098002"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_003060"/>
    <dbReference type="eggNOG" id="KOG4210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026791_2_0_1"/>
    <dbReference type="InParanoid" id="B8MT40"/>
    <dbReference type="OMA" id="EIRIVMN"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="231"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="337"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="412"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="421"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED12243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="479" mass="51337" checksum="FE3B22071F03DE30" modified="2009-03-03" version="1">MSKTKSTTKANKATDKVLSKVKDAGVTKPSQSPKAKSKEIARKLKTKGEKAALKKKEPTPSSESDSDSDEDMKSASSSESESESEEEKKETKKPGKAAAKKEESSESESESESESEEEKPAPKAKKVAAKEESSESESSESESESEEEVKKTDKKAGAKVAAEEEASSDESDSSESESEAKADKESESESESDSDSSESEEEKEAPKKRKAEEEPATNAKKSKTESADNSPNLFVGNLSWNVDEEWLRREFEEFGELSGVRIMTERESGRSRGFGYVEYADASSAKAAYEAKKDAEIDGRTINLDYAKPRDANNQAPREKAQNRARSFGDQTSPESNTLFVGNLVFGVDENAVREVFEGQGQIQGIRLPTDAETGRPKGYGYVEFSSVDEARQALNDLQGTDIGGRAIRLDFSTPRAQGDGNRGGRGGRGGFGGRGGGRGGQRGGRGGFGGRGRGGATGANTTNRGGFGDFSGKKISFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTT3</accession>
    <name>B8MTT3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_005980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488222.1">
        <property type="nucleotide sequence ID" value="XM_002488177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTT3"/>
    <dbReference type="STRING" id="441959.B8MTT3"/>
    <dbReference type="GeneID" id="8105571"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_005980"/>
    <dbReference type="HOGENOM" id="CLU_2185711_0_0_1"/>
    <dbReference type="InParanoid" id="B8MTT3"/>
    <dbReference type="PhylomeDB" id="B8MTT3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="120" mass="13592" checksum="6A8D7B60E85994E9" modified="2009-03-03" version="1">MLSNIATKYKLNSPEDWDDWQNELLNRARANDLLPILQGTERPIKKPVRPKIQDYLPESQNTTQNRVGAAQGTRQNSAQSTQTTATEDITDDRTEQRARNDFNLLSGRFSVETSTKSLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTV5</accession>
    <name>B8MTV5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_005350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488152.1">
        <property type="nucleotide sequence ID" value="XM_002488107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTV5"/>
    <dbReference type="GeneID" id="8105509"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_005350"/>
    <dbReference type="eggNOG" id="ENOG502SIUS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019189_1_0_1"/>
    <dbReference type="InParanoid" id="B8MTV5"/>
    <dbReference type="OMA" id="KMNEYLF"/>
    <dbReference type="OrthoDB" id="2831558at2759"/>
    <dbReference type="PhylomeDB" id="B8MTV5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="54300" checksum="84AE8C84568766B0" modified="2009-03-03" version="1">MEYSNEVVAKIPCPNAGVPSLTTASDVATLEFLRTHTSTQRVTLADSWDTMSTLERYKVTDRVVEMEKELYTVQFPAYGSLYRDSVPHDCHYHPLPPNLDPTGLFYIGPSCSRTVWHRNSKDISEPDVGPCLIFASFGYFQLLTHMKRPLSGSLFYPAQDQQPNHFSQSQSAEEYKYLLEKVIQVLLILSQDSHVLEGTSPVIGHTNLHLGNIYVSREDPTLIEGIIDWQSTQVAPLLIQARFPGFLRPPKTYESGTEVPSLSTSFDELGPSEKAKITSENELASRSKYYEMSCLAYNKRVYNAMELDRRLWGPFTCCQLFFKWQLGSTTKLSGSHFQDWNVFDLPENCTQEELQGYDEQVVQYQDRLYLWDIAKTQLCTADSGWVPMFIISPSLPAQSTLVSRACLLLAALFLGHSCSPELLRASREGSSATSPLVVRFFLTVYLTIHIIIAWLILDFLSHINLALILRIEGSRTLGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUH1</accession>
    <name>B8MUH1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_110230</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488599.1">
        <property type="nucleotide sequence ID" value="XM_002488554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUH1"/>
    <dbReference type="STRING" id="441959.B8MUH1"/>
    <dbReference type="GeneID" id="8107255"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_110230"/>
    <dbReference type="eggNOG" id="KOG1397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008721_4_2_1"/>
    <dbReference type="InParanoid" id="B8MUH1"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="PhylomeDB" id="B8MUH1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000024">
        <property type="entry name" value="Calcium/proton exchanger, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF20">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="371"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="86"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="305"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED11843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="454" mass="48763" checksum="DEE1111FEE5B213E" modified="2009-03-03" version="1">MSQDLESGRHCDLRFENSSMPPNPGAMNTNTGVNNLRTTESFDSSKRPVFTIASQLRATIFKSWINLLLFCVPAGIAINYCNLNMTAVFVVNFIGIIPLAAMLSDATEEIALRTGETIGGLLNASFGNAVELIVAIIALVHDEVTIVQTSLIGSMLSNLLLVMGMCFFFGGINRTEQKFSKLFAQTGASLLALAVASLIIPTAFRKWSAGGASHTDELSRGVSVILLLVYTCYLIFQLKTHADIYNKPSEKTEKRNKSRAKGDTQKGVVAMSGLSAYIVTGTPQLGLPVDEKDEKETPQLHFYVAVLVLVLSTLFIALCAEFMVNAIDAVTSGTSGVSKTFIGLILLPIVGNAAEHATAVTCAVKDKMDIAIAVAVGSSMQIALLVLPLVVVLGWVMGNDNMTLDFGDGFQVVVLFMAVLLVNYLIADGKSNWLEGILLMTLYIIIAISGWLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-02-22" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUQ8</accession>
    <name>B8MUQ8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_109060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488481.1">
        <property type="nucleotide sequence ID" value="XM_002488436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUQ8"/>
    <dbReference type="GeneID" id="8103162"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109060"/>
    <dbReference type="HOGENOM" id="CLU_2924301_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUQ8"/>
    <dbReference type="PhylomeDB" id="B8MUQ8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="61" mass="6468" checksum="9EC509D62331AA4C" modified="2009-03-03" version="1">MSTKAVLITDQLEKPESDSSHYRVLLVCNLNTAKASASVNVKAGTFNDKGLPGMAHPNSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8LSZ7</accession>
    <name>B8LSZ7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kelch repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_064590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340380.1">
        <property type="nucleotide sequence ID" value="XM_002340339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LSZ7"/>
    <dbReference type="STRING" id="441959.B8LSZ7"/>
    <dbReference type="GeneID" id="8106214"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_064590"/>
    <dbReference type="eggNOG" id="ENOG502S423">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_903664_0_0_1"/>
    <dbReference type="InParanoid" id="B8LSZ7"/>
    <dbReference type="OrthoDB" id="4222185at2759"/>
    <dbReference type="PhylomeDB" id="B8LSZ7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED22993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="33362" checksum="C07B3945926E3503" modified="2009-03-03" version="1">MLKPFYTGNYVNNPDTSSGGRIARTLCNKVGDFCASRIIRSGASSTLHLRRYFYVLGAKTYNVTTNQWKEVNVTGGEFNFGNRTSSQYVSVPESGLGFIYGGTDYMGGMIRFDASDLENLLWTNETLGNGSHRSNVPNLESAAMVFIPAGDKGMLVTFGGGNVSAGISPDSGWPYDSNWLTVYVYDIASHTWRAQEASGDTPFHRTSFCAVVTEAADGSAFHITTYGGWSLLDQRSYEDIDATDLSNHTNKGQQVNVNPTIGRDSLTGACQVYRGTEMIVLGGEVREGAYSLANGACSNTFEPARALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8LT24</accession>
    <name>B8LT24_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Epoxide hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_069520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340919.1">
        <property type="nucleotide sequence ID" value="XM_002340878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LT24"/>
    <dbReference type="STRING" id="441959.B8LT24"/>
    <dbReference type="GeneID" id="8101265"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_069520"/>
    <dbReference type="eggNOG" id="KOG2565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8LT24"/>
    <dbReference type="OMA" id="MEMPSML"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="PhylomeDB" id="B8LT24"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF39">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="4">
        <location>
            <begin position="16"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED23532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="395" mass="45063" checksum="4BC2C2FC3B33B541" modified="2009-03-03" version="1">MSLKFATVPAGAKVQPKPFKVSIPDEQLEELQTLIRLAKTAPPTYEGSQEDGRLGVPSSWLANAKEEWKKFDWRESENEFNEFPQFTYEIEGLRMHFVALFSEKEDAKPIAFLHGWPGSFLEFLPLLSLFREKYEPTTLPYHLIVPSLPGYTFSSDLPADRDFTSPDAARILNQLMVNLGFGNGYVVQGGDVGSKIGRILGAKYDSCKAVHLNFAGKLNPPKDATEDLSAVEQEGLKRAQWFGTYGTAYYFDHATRPSTISHILSTNPVALLIWIGERFRDWPDKRNPVPLRTILQEVTLYWLTDTFPRSIYTYRETYPPPPVPPAQQPDQYIHKPFGFSYFPQEVIPAPRSWVERTGNLVFWKEHTKGGHFAALECPQELADDIVEFVEQVWQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8LT90</accession>
    <name>B8LT90_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase epsilon subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA polymerase II subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_070120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase epsilon subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340985.1">
        <property type="nucleotide sequence ID" value="XM_002340944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LT90"/>
    <dbReference type="FunCoup" id="B8LT90">
        <property type="interactions" value="760"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LT90"/>
    <dbReference type="GeneID" id="8108603"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_070120"/>
    <dbReference type="eggNOG" id="KOG3818">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010628_1_0_1"/>
    <dbReference type="InParanoid" id="B8LT90"/>
    <dbReference type="OMA" id="PEDGAWF"/>
    <dbReference type="OrthoDB" id="10254730at2759"/>
    <dbReference type="PhylomeDB" id="B8LT90"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016266">
        <property type="entry name" value="POLE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="9">
        <location>
            <begin position="421"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="142"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="599"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="599"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="617"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED23598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="746" mass="81322" checksum="B8EED5BB8595C06F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTC2</accession>
    <name>B8LTC2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_059940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002339883.1">
        <property type="nucleotide sequence ID" value="XM_002339842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTC2"/>
    <dbReference type="STRING" id="441959.B8LTC2"/>
    <dbReference type="GeneID" id="8108524"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_059940"/>
    <dbReference type="eggNOG" id="ENOG502RF8N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015502_0_0_1"/>
    <dbReference type="InParanoid" id="B8LTC2"/>
    <dbReference type="OMA" id="LYYQNFH"/>
    <dbReference type="OrthoDB" id="2399539at2759"/>
    <dbReference type="PhylomeDB" id="B8LTC2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED22496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="417" mass="47217" checksum="09AB0B9B472F11EF" modified="2009-03-03" version="1">MPLRSNARNPSSLACIPCRQRHLKCDALIPPCSRCKQSNVKCHYVASKRGLRRKDSTTTSPPTTEPVDADASCTSPPYTQTLTPTFSPGISEFLPSLDETSQRLAGLSTPEETRTVVSTESCAVPAYHNIAFDPMIKLYYQNFHSSHPFVIPRKSLSNYDLTRFLPPCLISMMQFIGSHFHPDPTVKDRYQKKAYMSLNDSSEPSGFKVQAMLLAAIAYHAHGNEEQAGYMLNSAITMASQLGIQSGSFAGHSYPGNAILEESWRRTFWELFIVVHLFKTFSAQQNCDIQWSGYRDEDLLKMELPCDEATYYAAGSIPQSKTLPQLQNVWRSVNNDTEETFSSFSYRIEAIRLWEMVQSVNSRSTALMYIDEIELDTLDIRLTTLLIRLMKIYQCFTSSANEPDDQMRRQAQMITLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTD2</accession>
    <name>B8LTD2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_064760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340397.1">
        <property type="nucleotide sequence ID" value="XM_002340356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTD2"/>
    <dbReference type="STRING" id="441959.B8LTD2"/>
    <dbReference type="GeneID" id="8104199"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_064760"/>
    <dbReference type="HOGENOM" id="CLU_058063_0_0_1"/>
    <dbReference type="InParanoid" id="B8LTD2"/>
    <dbReference type="OrthoDB" id="4220248at2759"/>
    <dbReference type="PhylomeDB" id="B8LTD2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF1">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="17"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="334" mass="38957" checksum="E25904982152B6F0" modified="2009-03-03" version="1">METSQTDSSSRNEDTRFHLFPRLPTEIRLEIWRASLPRRIISLDSRNPCPGPSKDFIQIWQRPPSIACVCKEARSVAFQHGRLRWAENVDGPDKRLLETIPEHILADHLLADAKQAKAVVISSSYMNFHHIEETARLLTFLNNPFLYIARNYVVHMSKGEAIDSGLFGFNAEEPIVLVDDKDKDQLRKYAAVCSLTEDNLFPLEDHLDSLEKSPESEPIHNEFAHGDISRMWLHLQRHGIPAYGKAKGNPRYEGLYNQFGFLNRDHHMVKSARETIPKYRLMFVFELCRNSRHLLIMEHQQNKKAFNSVCQDIFRRKIYTTEQLREYLIDNMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTI6</accession>
    <name>B8LTI6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS5m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_065220</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340451.1">
        <property type="nucleotide sequence ID" value="XM_002340410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTI6"/>
    <dbReference type="STRING" id="441959.B8LTI6"/>
    <dbReference type="GeneID" id="8109426"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_065220"/>
    <dbReference type="eggNOG" id="KOG2646">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037994_1_0_1"/>
    <dbReference type="InParanoid" id="B8LTI6"/>
    <dbReference type="OMA" id="IYEMCRA"/>
    <dbReference type="OrthoDB" id="309483at2759"/>
    <dbReference type="PhylomeDB" id="B8LTI6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000022">
        <property type="entry name" value="28S ribosomal protein S5, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000041">
        <property type="entry name" value="37S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="11">
        <location>
            <begin position="257"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED23064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="420" mass="47156" checksum="0F31BA9AE53B4D79" modified="2009-03-03" version="1">MNVLQPARCLFCSFSQTARVGARVPVQREFHAAAALYARKPPGPRPTAKKPGQKKTWDDIEKKLRPSDFADYSSKELRQLSQEYTEDQVAAILAAEKAIDPKDLVEQFAIRNDPMKLGYLDDFSTIEPVVDKHIRAPESNSDWHATLKSEDDFAEDFAKFFAEMPDNATAADWVRFTENLRLTKGKEENERNPSSALVPDIFEEGETLSNPFSKDVEATSDQKKKKTEGNRSNEEITDALKRLMQSTGYSLDKIKSLKVKTLVSHAVVNQTRLGKVRRQYCLSVAGNGDGLLGIGEAKSEEASDAVTQSKYRAIRNMQPILRYENRTIYGDVKGKVGAVELKLMNRPPGFGLRCQHLIYEMARAAGIHDLAARVERSRNPMNTVKAAYEALTAQKDPEEIARARGRKLVDVRKVYYAGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTQ1</accession>
    <name>B8LTQ1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_070530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341030.1">
        <property type="nucleotide sequence ID" value="XM_002340989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTQ1"/>
    <dbReference type="STRING" id="441959.B8LTQ1"/>
    <dbReference type="GeneID" id="8104746"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_070530"/>
    <dbReference type="eggNOG" id="ENOG502S1UN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017096_0_0_1"/>
    <dbReference type="InParanoid" id="B8LTQ1"/>
    <dbReference type="OMA" id="GRIYWFK"/>
    <dbReference type="OrthoDB" id="14339at2759"/>
    <dbReference type="PhylomeDB" id="B8LTQ1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332:SF1">
        <property type="entry name" value="ELMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED23643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="316" mass="34684" checksum="C27D091CD9E1FB82" modified="2009-03-03" version="1">MTAADLLPYQITVHGHTSLLTMSGIPMPAQQGTSVGPQSAASIFQHVHDMSSKRVSTLGYLRKVHEGRVYWFNTVHFSRHDLMRMPYFDPKRLSRRAINFLLLGLSLPPILDAYTTPMEYLRALHALLVEFETFQQVHNPDGNFSSNLVRARLPQMFKRATYTGNKTRRASSANEIGLPMHFGDSSDVKAMTGNLASSATAASAVTSFPNTDSSDLLPGEEYTYLLTPSLPFDPDFFETFVTLCDVLIDCYNRLTGLVSSPSVCTTGFGELFTKTDAKLRKVMVAGVVRDFEDASRSGAKSEIGGVSRVVLGGLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUI3</accession>
    <name>B8LUI3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Amino acid transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_071530</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341143.1">
        <property type="nucleotide sequence ID" value="XM_002341102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUI3"/>
    <dbReference type="FunCoup" id="B8LUI3">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LUI3"/>
    <dbReference type="GeneID" id="8110253"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_071530"/>
    <dbReference type="eggNOG" id="KOG1305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009020_4_1_1"/>
    <dbReference type="InParanoid" id="B8LUI3"/>
    <dbReference type="OMA" id="FLFFGSQ"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="PhylomeDB" id="B8LUI3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="493"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="181"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED23756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="587" mass="64015" checksum="DF3E0BBCE2E31F91" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVG1</accession>
    <name>B8LVG1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar transporter chaperon Vtc1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_073680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341367.1">
        <property type="nucleotide sequence ID" value="XM_002341326.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341368.1">
        <property type="nucleotide sequence ID" value="XM_002341327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVG1"/>
    <dbReference type="FunCoup" id="B8LVG1">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LVG1"/>
    <dbReference type="GeneID" id="8105121"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_073680"/>
    <dbReference type="eggNOG" id="KOG4580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141247_1_0_1"/>
    <dbReference type="InParanoid" id="B8LVG1"/>
    <dbReference type="OMA" id="MAIMIYA"/>
    <dbReference type="OrthoDB" id="2243669at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016237">
        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="24"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED23980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="126" mass="13936" checksum="36DC3A7C36A5EB2B" modified="2009-03-03" version="1">MSSQPLLQTVPGKRIALPTRVEPKVFFANERTFLSWLNFTVILGGLAIGLLNFGDRVGRISAGLFTIIAMAAMVYALFTFHWRAQSIRKRGQSGFDDRFGPSLLAVALLAAVIVNFVLRIREANRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXG1</accession>
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        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">TSTA_066850</name>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340629.1">
        <property type="nucleotide sequence ID" value="XM_002340588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXG1"/>
    <dbReference type="STRING" id="441959.B8LXG1"/>
    <dbReference type="GeneID" id="8105091"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_066850"/>
    <dbReference type="eggNOG" id="ENOG502SKK7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014802_0_0_1"/>
    <dbReference type="InParanoid" id="B8LXG1"/>
    <dbReference type="OMA" id="YAHTFAQ"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="PhylomeDB" id="B8LXG1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="82"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED23242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="744" mass="82288" checksum="85B4663C8F1C32DF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXR5</accession>
    <name>B8LXR5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_080050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002342037.1">
        <property type="nucleotide sequence ID" value="XM_002341996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXR5"/>
    <dbReference type="STRING" id="441959.B8LXR5"/>
    <dbReference type="GeneID" id="8102420"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_080050"/>
    <dbReference type="eggNOG" id="KOG4369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_300187_0_0_1"/>
    <dbReference type="InParanoid" id="B8LXR5"/>
    <dbReference type="OMA" id="DCMWLAA"/>
    <dbReference type="OrthoDB" id="4540681at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF194">
        <property type="entry name" value="INVERSIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="796"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="829"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="862"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="896"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="930"/>
            <end position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED24650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="998" mass="108920" checksum="15F1E9318ECDE231" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B8LY27</accession>
    <name>B8LY27_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA mismatch repair protein Mlh1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_067130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340659.1">
        <property type="nucleotide sequence ID" value="XM_002340618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LY27"/>
    <dbReference type="FunCoup" id="B8LY27">
        <property type="interactions" value="761"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LY27"/>
    <dbReference type="GeneID" id="8101153"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_067130"/>
    <dbReference type="eggNOG" id="KOG1979">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004131_2_0_1"/>
    <dbReference type="InParanoid" id="B8LY27"/>
    <dbReference type="OMA" id="ANYHVKK"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="PhylomeDB" id="B8LY27"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03483">
        <property type="entry name" value="MutL_Trans_MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000033">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="7">
        <location>
            <begin position="247"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="560"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="670"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="564"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="705"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED23272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="764" mass="85182" checksum="EBBD71CA50E9767F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYC8</accession>
    <name>B8LYC8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_063380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340244.1">
        <property type="nucleotide sequence ID" value="XM_002340203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYC8"/>
    <dbReference type="STRING" id="441959.B8LYC8"/>
    <dbReference type="GeneID" id="8105995"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_063380"/>
    <dbReference type="eggNOG" id="ENOG502S0EY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_22_1"/>
    <dbReference type="InParanoid" id="B8LYC8"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="PhylomeDB" id="B8LYC8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED22857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="43329" checksum="27EB38C2670912B8" modified="2009-03-03" version="1">MSLLASSGIVIVIPNIDDSKAIGHASIKILSIRLSVGPWFNENIADPFELFSWEANLYPLVDTAEVSQEQFTAAILRALPLEIDAFSSLFDEFWDKSIDLIRKAPNDFNAYTIGRMHKHMVVLVPARSVCYKPAVNFSKHKAGFGGRNMWWCSLLRRKTRNYHWRCCHKRRDRSKSTSGFSSEEIHAGTLGRPNVAIRSLLQKIKTKLIQERLAKKMANNLQNIHNNLGCDSAQYPEIDQDELFIPTTLISTILRAFAPRVINFRAPLIQCMKTSLIYLGATRIPSSQMIYIALFGSGDRVMKSGLDRDEIATRDKVMAFEMEGARVWDILPCIVIKGVCDYADSHKNEVWQHCADATGAACMRAVLDEWPIGLCGNCSQLLASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYP1</accession>
    <name>B8LYP1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methionine-tRNA synthetase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_068250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340786.1">
        <property type="nucleotide sequence ID" value="XM_002340745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYP1"/>
    <dbReference type="STRING" id="441959.B8LYP1"/>
    <dbReference type="GeneID" id="8108599"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_068250"/>
    <dbReference type="eggNOG" id="KOG1247">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2265525_0_0_1"/>
    <dbReference type="InParanoid" id="B8LYP1"/>
    <dbReference type="OrthoDB" id="5844513at2759"/>
    <dbReference type="PhylomeDB" id="B8LYP1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="103" mass="11442" checksum="712254922BF729AB" modified="2009-03-03" version="1">MPYVNNVPHLGNIIGLVLSADGTDDYGTTTEAKALMEICTPRELCDKYHALHAEKRQGHNFIEKSTSPSWQIALLKGNVLYVVIPTLVVINVMVVARFSEPYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYP5</accession>
    <name>B8LYP5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL6m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_068300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340790.1">
        <property type="nucleotide sequence ID" value="XM_002340749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYP5"/>
    <dbReference type="FunCoup" id="B8LYP5">
        <property type="interactions" value="654"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LYP5"/>
    <dbReference type="GeneID" id="8102424"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_068300"/>
    <dbReference type="eggNOG" id="KOG3254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065464_1_0_1"/>
    <dbReference type="InParanoid" id="B8LYP5"/>
    <dbReference type="OMA" id="RERHGLC"/>
    <dbReference type="OrthoDB" id="540873at2759"/>
    <dbReference type="PhylomeDB" id="B8LYP5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000001">
        <property type="entry name" value="50S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000009">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_uL6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_uL6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 10" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="9">
        <location>
            <begin position="169"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED23403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="253" mass="27533" checksum="7EEE1397B8B7739F" modified="2009-03-03" version="1">MSCAASQRCLVQLLREPIRSKSVPAFLVPALSQPLRAQCFSTTSAARSRIGGAPVSIPPEVNLSLIDLPQIKARGKAKDAPKMAVEVNGPLGQMTLNIPPFVNINHDQTARKATISVQDAEVPHQRAMWGTTRAHLQNYVLGVSEGHICILSLVGVGYRATIESTATTVTAEYPGQQFVSLKVGYSHPIELPIPKGVKASTPQPTRILLESIDKEVVTQFAAEIRAWRKPEPYKGKGIFVNGETIRLKNKKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYR2</accession>
    <name>B8LYR2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">assimilatory sulfite reductase (NADPH)</fullName>
            <ecNumber evidence="4">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TSTA_068450</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="4"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340807.1">
        <property type="nucleotide sequence ID" value="XM_002340766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYR2"/>
    <dbReference type="FunCoup" id="B8LYR2">
        <property type="interactions" value="430"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LYR2"/>
    <dbReference type="GeneID" id="8110198"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_068450"/>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003662_1_0_1"/>
    <dbReference type="InParanoid" id="B8LYR2"/>
    <dbReference type="OMA" id="MIVAVNW"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="PhylomeDB" id="B8LYR2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009337">
        <property type="term" value="C:sulfite reductase complex (NADPH)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06207">
        <property type="entry name" value="CyPoR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000007">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000010">
        <property type="entry name" value="Sulfite reductase [NADPH] flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000052">
        <property type="entry name" value="Sulfite reductase [NADPH] flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000011">
        <property type="entry name" value="Sulfite reductase flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF109">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] FLAVOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="19">
        <location>
            <begin position="643"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00059320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EED23420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1030" mass="114332" checksum="1EE5EA4159A5D3F3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYY1</accession>
    <name>B8LYY1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine-specific methyltransferase SAM-dependent domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_069100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340876.1">
        <property type="nucleotide sequence ID" value="XM_002340835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYY1"/>
    <dbReference type="STRING" id="441959.B8LYY1"/>
    <dbReference type="GeneID" id="8104733"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_069100"/>
    <dbReference type="eggNOG" id="ENOG502QS9T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049766_0_2_1"/>
    <dbReference type="InParanoid" id="B8LYY1"/>
    <dbReference type="OMA" id="RVEMHLV"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="PhylomeDB" id="B8LYY1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017805">
        <property type="entry name" value="SAM_MeTrfase_EasF-type_put"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03439">
        <property type="entry name" value="methyl_EasF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF2">
        <property type="entry name" value="HISTIDINE-SPECIFIC METHYLTRANSFERASE SAM-DEPENDENT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="3">
        <location>
            <begin position="70"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED23489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="363" mass="41308" checksum="DC949F275CFE762B" modified="2009-03-03" version="1">MFENIIPLQLTQSQRRLRDSKPLFPRSSTTANNIIDIRPHPEMTDNTLRESIQESLNKITSGQDSEFYVGMPSLLLWNEQGLRYFEDVTYSPSYYLTNEEIGLLEKHKYKIAERIESGSMLVELGSGNLRKIKVLLEALDNLGREVDYFALDVSLPELQRTISLVPPGYFRHVRCFGLLGTYDDGREWLNKPELQSRPKTLLSLGSTLGSFQRHEIGGFLRSFFSSSGRNPSFFVGLDGCKDAQRVYNAYNDPEGANQRFVKNGLHRANQILAYEAFDLEHWHVKGVWEEENGRHSQYYYLDADVSLGDGMQVPAGKSLLAIQSHKYDSDDQAWLAESAGLEIVESWSSGQGYSLLFLGEQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZ57</accession>
    <name>B8LZ57_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_083330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478064.1">
        <property type="nucleotide sequence ID" value="XM_002478019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZ57"/>
    <dbReference type="STRING" id="441959.B8LZ57"/>
    <dbReference type="GeneID" id="8105211"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_083330"/>
    <dbReference type="eggNOG" id="ENOG502SIFT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_1_3_1"/>
    <dbReference type="InParanoid" id="B8LZ57"/>
    <dbReference type="OMA" id="SSHVCKG"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="PhylomeDB" id="B8LZ57"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF12">
        <property type="entry name" value="STERIGMATOCYSTIN 8-O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="177"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED21101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="433" mass="48972" checksum="A8330C9C7ACB1D7B" modified="2009-03-03" version="1">MEGMTIDQLASDILSECTLMQRYCQTTGIALPSLLAGATPDFWSTDSPQELIAARTRTLGLLERITTLLRGPHDFIHEYVASNWDQGALYVFLRTRLLEHIAVLGGEANIGNLATASGVPEDKLIRILGLLCCKNIVRQSDNGIYALTAISEDMIQDPDFRAWVEFQLFETRIASVHLADALESKPNTYTDGKSAFKQGFGVEMYEWHTSHPEEGDRFRRAMKGVSNSLDPADSLIRTWIKNRPSSNLTKVVEIGGRYGFASTTLVREKEDLSFELRCDSEEFLRRGQALVDPRSMSRISFTHLTSNFEPPPPSDANTVCAYVIRNLFWNWTDDEAVRLLQQLAQILHGSPWTHIIVTDGVSPLPGEFPPHVEISYRRRDITTMTMHNVKQRSQEEWLKLFSRVDPALKITTHFESSSHVCKGLWELRLETGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZS7</accession>
    <name>B8LZS7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_080920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477822.1">
        <property type="nucleotide sequence ID" value="XM_002477777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZS7"/>
    <dbReference type="STRING" id="441959.B8LZS7"/>
    <dbReference type="GeneID" id="8101397"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_080920"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_23_3_1"/>
    <dbReference type="InParanoid" id="B8LZS7"/>
    <dbReference type="OMA" id="ANESHRE"/>
    <dbReference type="OrthoDB" id="4368687at2759"/>
    <dbReference type="PhylomeDB" id="B8LZS7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="455"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1077" mass="122018" checksum="283E3EFDA658AD18" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZV4</accession>
    <name>B8LZV4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_081190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477849.1">
        <property type="nucleotide sequence ID" value="XM_002477804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZV4"/>
    <dbReference type="STRING" id="441959.B8LZV4"/>
    <dbReference type="GeneID" id="8101424"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_081190"/>
    <dbReference type="HOGENOM" id="CLU_2962480_0_0_1"/>
    <dbReference type="InParanoid" id="B8LZV4"/>
    <dbReference type="PhylomeDB" id="B8LZV4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED20886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="59" mass="6598" checksum="85ED1F16A03BA6BC" modified="2009-03-03" version="1">MAPNPDLNGFEPEGKNRTQLDTYVSVLRLAKLIVLLKSHSVYVDETNEHLVAQNVYDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0L1</accession>
    <name>B8M0L1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_085390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478271.1">
        <property type="nucleotide sequence ID" value="XM_002478226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0L1"/>
    <dbReference type="STRING" id="441959.B8M0L1"/>
    <dbReference type="GeneID" id="8106145"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_085390"/>
    <dbReference type="eggNOG" id="KOG0047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1277538_0_0_1"/>
    <dbReference type="InParanoid" id="B8M0L1"/>
    <dbReference type="OMA" id="FRHSANT"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="PhylomeDB" id="B8M0L1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="230" mass="26011" checksum="61F0B5743E26B2CA" modified="2009-03-03" version="1">MTAPRVRQAHPDWTGTRGTSILTLSKPPFPPGNSIEDSPDPLLQFHMFFYRDAQFHRIGVSTSTFFPFLSYLRLGSKLPLHGLILFIPQLRRALRVGVNHAKNPQYTPNGFVNKSRPDTADNTVSREPNFYHEGKASDYHQPRVLCQKVMTSKARENLHLNTARVLNCTGLIRSMRNAVYDLLPEKKFDMLEVQEASKNAEMAGKSQKFRHSANTDVSMGTVPSVPIYNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0Y4</accession>
    <name>B8M0Y4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_090030</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478727.1">
        <property type="nucleotide sequence ID" value="XM_002478682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0Y4"/>
    <dbReference type="FunCoup" id="B8M0Y4">
        <property type="interactions" value="348"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M0Y4"/>
    <dbReference type="GeneID" id="8108091"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_090030"/>
    <dbReference type="eggNOG" id="KOG0752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_10_9_1"/>
    <dbReference type="InParanoid" id="B8M0Y4"/>
    <dbReference type="OMA" id="YKMSVPK"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="PhylomeDB" id="B8M0Y4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="53"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="150"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="256"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED21764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="352" mass="38865" checksum="6B48ED7344FD4BB5" modified="2009-03-03" version="1">MSLNRQDSAQGEDLGSDSDKLHESSRLPTLASEYATKPVATSFLQRTKYNLSEPVVAAFIAGGVAGAVSRTIVSPLERLKILLQIQSVGREEYRLSIWKALVKMRKEEGWRGFMRGNGTNCIRIIPYSAVQFGSYNFYKKFIEPTPGADLTPVRRLFCGALAGITSVTFTYPLDIVRTRLSIQSASFAELGQREAGEKLPGMFETMVMMYKTEGGMLALYRGIIPTVAGVAPYVGLNFMVYESVRVYLTPEGEKNPSPARKLLAGAISGAVAQTCTYPFDVLRRRFQINTMTGMGYQYASIWDAVKVIVAQEGIQGLYKGIVPNLLKVAPSMASSWLSFEITRDLLVGMREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1C6</accession>
    <name>B8M1C6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_090610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478785.1">
        <property type="nucleotide sequence ID" value="XM_002478740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1C6"/>
    <dbReference type="GeneID" id="8101552"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_090610"/>
    <dbReference type="eggNOG" id="ENOG502SAP8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054245_0_0_1"/>
    <dbReference type="InParanoid" id="B8M1C6"/>
    <dbReference type="OMA" id="VSDHRLK"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="PhylomeDB" id="B8M1C6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="154"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED21822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="313" mass="34697" checksum="B38127E3C6A45B88" modified="2009-03-03" version="1">MNPPAKRSETNPKPKNKHIFDPWNSSSTGHQRAENPYSRTTDWRDTRRDKLARQFRFASNNGDDGSLMRDGGGSYMTETKADGGGGGGEGEWKWMSAQEAKRNELRVRDIRRYMGGISKPPLQPLMTTTTTTTTKEKLILEPDESDPKNRKVREEKGIFTHLTFYINGSTYPTISDHKLKHLLAEEGGNISLYLARKSVTHVILGSSATSNMSSAGTAGRKTGRLLASSKLQKEIVAKTSGFGRGVKYVNVEWVIESIKAGKKLPEARFSPSTFSSMSRLGNFTRVGVPAGQKSVYDTFNRSTTTTKSMDEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1F4</accession>
    <name>B8M1F4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_090900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478813.1">
        <property type="nucleotide sequence ID" value="XM_002478768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1F4"/>
    <dbReference type="GeneID" id="8101580"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_090900"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="InParanoid" id="B8M1F4"/>
    <dbReference type="OMA" id="HLTWRWA"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="PhylomeDB" id="B8M1F4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000436">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF78">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="26"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="511"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="520"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="542"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED21850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="567" mass="61671" checksum="785130BD79BF589D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1H4</accession>
    <name>B8M1H4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione S-transferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_091100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478833.1">
        <property type="nucleotide sequence ID" value="XM_002478788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1H4"/>
    <dbReference type="STRING" id="441959.B8M1H4"/>
    <dbReference type="GeneID" id="8101600"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_091100"/>
    <dbReference type="eggNOG" id="ENOG502S4E5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110291_1_1_1"/>
    <dbReference type="InParanoid" id="B8M1H4"/>
    <dbReference type="OMA" id="ACQHLGW"/>
    <dbReference type="OrthoDB" id="410651at2759"/>
    <dbReference type="PhylomeDB" id="B8M1H4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050997">
        <property type="entry name" value="MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250:SF26">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED21870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="151" mass="16495" checksum="5081D1AED8B12A1B" modified="2009-03-03" version="1">MVSITVPENYGAVIAVALGGIPLLSWVQGNIVTSLRKPAKIRYPQYYATPAECKENPAAYKFNCAQRAHGNLLENMPQTILYMLIAGLKWPNATAALGTAWIVFRALYAHGYVTAAKPNGVGRFHGAPFWLVQGALWGMAVFGVGWELIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8M201</accession>
    <name>B8M201_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase, zinc-binding dehydrogenase family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_086100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478342.1">
        <property type="nucleotide sequence ID" value="XM_002478297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M201"/>
    <dbReference type="STRING" id="441959.B8M201"/>
    <dbReference type="GeneID" id="8104575"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_086100"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_2_1"/>
    <dbReference type="InParanoid" id="B8M201"/>
    <dbReference type="OMA" id="IDWKGPA"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="PhylomeDB" id="B8M201"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052585">
        <property type="entry name" value="Lipid_raft_assoc_Zn_ADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482">
        <property type="entry name" value="PROTEIN AST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482:SF2">
        <property type="entry name" value="ZINC-BINDING DEHYDROGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="100"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED21379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="468" mass="50780" checksum="83BF1AC3F181B8BB" modified="2009-03-03" version="1">MATTTTTWITTTDSISHKHDFTESRNDSYLRSSSSTLRPLPLTEEQNIIKKEAYTETAEIKTTNIEQHSVPVPVVDKLAATQNALLLHAIKEKYTLVTDHAIPSIHHQDEILIEVSAIGLNPIDWKAPAFNFGIPSLPWVFGRDLAGKVIKTSSSSSRLQVGDLVLVPSTDYRDIRKAAFQEYAVTTHYNAAKIPPTTSIHGGASIGVAYVAAALALGVSFGLDFGLARSVPGPDLRTILKSVNAQDIPEDVRPECLPSSEAGAERVKKGDWIAIWGASTTTGYIALQLAKLCGLKVICIADIARHGQRLHALGADILVDRHDTNRAVDIIRGVTNGQLRFGIDIVGRDTATILEKALSQPHKEGGNEPQSHLLGLTGSPKEKKDGIVYHTVPIKIFHESPQVGEGLVKWLENLLEYKALTPPEVVIRDEGGLGGINDALDLLRSGEVSGKRIVVDLRRGDVKQSTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2G0</accession>
    <name>B8M2G0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA-binding La domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_088600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478587.1">
        <property type="nucleotide sequence ID" value="XM_002478542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2G0"/>
    <dbReference type="FunCoup" id="B8M2G0">
        <property type="interactions" value="678"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M2G0"/>
    <dbReference type="GeneID" id="8106957"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_088600"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043291_2_0_1"/>
    <dbReference type="InParanoid" id="B8M2G0"/>
    <dbReference type="OMA" id="PKPQWKG"/>
    <dbReference type="OrthoDB" id="439993at2759"/>
    <dbReference type="PhylomeDB" id="B8M2G0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08029">
        <property type="entry name" value="LA_like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12291">
        <property type="entry name" value="RRM1_La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF140">
        <property type="entry name" value="ACHILLES, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="7">
        <location>
            <begin position="95"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="204"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="295"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="323"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED21624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="396" mass="44452" checksum="3A9716F91941871B" modified="2009-03-03" version="1">MSAEEVKATETPQNGNADAAKDVQNLLAELKGDEEKKVESGAPAEEDEAAKEARIIAEATKLGKEQAEQESKDEKKPAERPRRNYRENIKSDLTAQEVTDDHNEIRKQVEFYFSDSNLPMDNFLLKKVGGSANHPVELSLLHSFKRMRRFQPFSAIVEALKTSTVLNLVDNDTKVKRKVPLPESVNDFLDPNVVKVFETEAMGRSVYVKGFGEEGPKTQFEIEAFFAPYGPTNAIRLRRAFDKTFKGSVFVEFDTEETQKKFLALDPPPKWNGKDLIIKSKKDYCDEKVRDIQAGKIKAGNRNSGRGGRGGRGGRGRGRGRGGRGDNDRRDWRERRDEDQKRGFREDKPTVQKDARGIPIVKSTEEPATSGQKRAREDTNGATNEHAAKKVDVKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2N4</accession>
    <name>B8M2N4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_091860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478908.1">
        <property type="nucleotide sequence ID" value="XM_002478863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2N4"/>
    <dbReference type="STRING" id="441959.B8M2N4"/>
    <dbReference type="GeneID" id="8098572"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_091860"/>
    <dbReference type="eggNOG" id="ENOG502S8JK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077442_2_0_1"/>
    <dbReference type="InParanoid" id="B8M2N4"/>
    <dbReference type="OMA" id="DVWSKPP"/>
    <dbReference type="OrthoDB" id="42525at2759"/>
    <dbReference type="PhylomeDB" id="B8M2N4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009784">
        <property type="entry name" value="DUF1349"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332:SF2">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07081">
        <property type="entry name" value="DUF1349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED21945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="198" mass="22416" checksum="A87EBB04C5A36141" modified="2009-03-03" version="1">MSDYKFINSSQSVPDAKDLPINYSIKASPSTDVWAKPPATHRFNAPILYKTIPLKSFKRVRVSIVAEWKVLYDQGGLIIVINNGKTDEQRQWIKCGIEFTNSKPHISVVAKDRWADWSLVPVPSGGQAVTIELVREEDNTLWVYLVEGISRVPLREVTWAFEQEETAECWVGSYAARPSSATTDDLVVDFRHLVVETH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3V0</accession>
    <name>B8M3V0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA damage-inducible protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_038970</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable aspartic protease. May be involved in the regulation of exocytosis. Acts as a linker between the 19S proteasome and polyubiquitinated proteins via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds ubiquitin and polyubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DDI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481127.1">
        <property type="nucleotide sequence ID" value="XM_002481082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3V0"/>
    <dbReference type="FunCoup" id="B8M3V0">
        <property type="interactions" value="281"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M3V0"/>
    <dbReference type="MEROPS" id="A28.A06"/>
    <dbReference type="GeneID" id="8107939"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_038970"/>
    <dbReference type="eggNOG" id="KOG0012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020435_2_0_1"/>
    <dbReference type="InParanoid" id="B8M3V0"/>
    <dbReference type="OMA" id="GHRLNAF"/>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="PhylomeDB" id="B8M3V0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05479">
        <property type="entry name" value="RP_DDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01796">
        <property type="entry name" value="Ubl_Ddi1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033882">
        <property type="entry name" value="DDI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019103">
        <property type="entry name" value="Peptidase_aspartic_DDI1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15397:SF3">
        <property type="entry name" value="DNA DAMAGE INDUCIBLE 1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15397">
        <property type="entry name" value="SODIUM-GLUCOSE COTRANSPORTER REGULATORY PROTEIN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09668">
        <property type="entry name" value="Asp_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="13">
        <location>
            <begin position="32"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="12">
        <location>
            <begin position="430"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="113"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="404"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="422"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED20693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="474" mass="51780" checksum="B84A6B39269CD908" modified="2009-03-03" version="1">MHLTVSGIVLHAMLELSNILLTILLTTIFWRIAVSVIKPDESDADIISLDVAGDMTLEVLKAVIESDSNIPPSSQRLVYNNQLLNNDTQTLEQVGISEGDMLLVHVGMGRPQAAGRSLGGGPSSSAAGNSQALQRQQQQQQQQQQQQPLFDTETLRLNLLGDPRVMETVRRQNPELAAVADDPRRFQEVLLSQKRREQELEREKEAKIAALNADPFNVDAQREIEEIIRQQAVTENLHNAMEHHPESFGRVTMLYIPVEVNGKPIKAFVDSGAQVTIMSPECAAACNIMRLVDQRYGGIAKGVGTAKIIGRVHSAQLKIGSMFLPCSFTVMEGKHIDLLLGLDMLKRHQACIDLKRGALVIQDQAVPFLGEADIPKEFQDEFEDEPLIRGADGAEIGARSGAVTLQAEKPPAQQQQTRTLGSETSTSQQSASSRWSASSINKITELGFSREQAISGLDASNGNVDQAIEFLLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8M460</accession>
    <name>B8M460_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_039970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481237.1">
        <property type="nucleotide sequence ID" value="XM_002481192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M460"/>
    <dbReference type="STRING" id="441959.B8M460"/>
    <dbReference type="GeneID" id="8109756"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_039970"/>
    <dbReference type="HOGENOM" id="CLU_1556303_0_0_1"/>
    <dbReference type="InParanoid" id="B8M460"/>
    <dbReference type="OrthoDB" id="3562262at2759"/>
    <dbReference type="PhylomeDB" id="B8M460"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="172" mass="19687" checksum="DC9DC9C38B4A3859" modified="2009-03-03" version="1">MYGGKETPAMQESGKAHRLKQFRTTVVRLYYKALDENDQDTNSEHTNEEPEAPLGINSTLPTSQDDEPDTSTPQPRPAQCPQRNRQLPARYRDDLIQLVFAQFDQSQEKEINSLLENGVFEVVKVDNILKGTRIFNSRFVNEIKNRGTDKAFEKSRLVVQAYNDKGKEIVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4A8</accession>
    <name>B8M4A8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Kinesin family protein (BimC), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSTA_024290</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479537.1">
        <property type="nucleotide sequence ID" value="XM_002479492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4A8"/>
    <dbReference type="FunCoup" id="B8M4A8">
        <property type="interactions" value="1031"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M4A8"/>
    <dbReference type="GeneID" id="8109611"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_024290"/>
    <dbReference type="eggNOG" id="KOG0243">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8M4A8"/>
    <dbReference type="OMA" id="DWETFDQ"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="PhylomeDB" id="B8M4A8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000073">
        <property type="term" value="P:initial mitotic spindle pole body separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01364">
        <property type="entry name" value="KISc_BimC_Eg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000051">
        <property type="entry name" value="Kinesin-like protein bimC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Microtub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10 14" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="17">
        <location>
            <begin position="79"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="992"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1099"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="473"/>
            <end position="549"/>
        </location>
    </feature>
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        <location>
            <begin position="740"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="26"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1134"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1168"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="163"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034704"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED19103.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1177" mass="131487" checksum="BFA2B5D5B6E8CB3C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4I1</accession>
    <name>B8M4I1_TALSN</name>
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        <submittedName>
            <fullName evidence="9">Clathrin-coated vesicle protein, putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="ORF">TSTA_024980</name>
    </gene>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP18 family.</text>
    </comment>
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    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502S3AC">
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    </dbReference>
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    <dbReference type="PhylomeDB" id="B8M4I1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019365">
        <property type="entry name" value="TVP18/Ca-channel_flower"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314:SF2">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10233">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003246"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005738"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED19176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="148" mass="16299" checksum="2669A59CF063CA07" modified="2009-03-03" version="1">MTLAEEFRTRNFSIYGQWTGVICIFLCFALGIANIFAPIGRIPFSIVCLCCAFVILFIEVPFLLRICPTSSKFDDFIRRFTSNYMRALIYIGMSAVQWVSLVTGASSLIAAAVFLLIAGLCYLLAGVRNQEFIGSKTLGGQGIAQMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8M579</accession>
    <name>B8M579_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_029600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480119.1">
        <property type="nucleotide sequence ID" value="XM_002480074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M579"/>
    <dbReference type="FunCoup" id="B8M579">
        <property type="interactions" value="1332"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M579"/>
    <dbReference type="GeneID" id="8106527"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_029600"/>
    <dbReference type="eggNOG" id="ENOG502SJG4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007426_5_0_1"/>
    <dbReference type="InParanoid" id="B8M579"/>
    <dbReference type="OMA" id="DERASCK"/>
    <dbReference type="OrthoDB" id="762982at2759"/>
    <dbReference type="PhylomeDB" id="B8M579"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="323"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED19685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="689" mass="78307" checksum="F5358FF483684852" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5V2</accession>
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        <submittedName>
            <fullName evidence="6">Protein phosphatase</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">TSTA_033260</name>
    </gene>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
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        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
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    <dbReference type="OrthoDB" id="271628at2759"/>
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    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PTP-MTM-like_fungal"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
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        <property type="entry name" value="PH-GRAM_MTMR6-9"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF128">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF21098">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
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        </location>
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        </location>
        <ligand>
            <name>substrate</name>
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        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED20079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="753" mass="85666" checksum="0CA519D3C61EC0C5" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5Z9</accession>
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        <recommendedName>
            <fullName evidence="2">DUF7924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_033680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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        </lineage>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480560.1">
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    </dbReference>
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    <dbReference type="STRING" id="441959.B8M5Z9"/>
    <dbReference type="GeneID" id="8097785"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_033680"/>
    <dbReference type="HOGENOM" id="CLU_1062362_0_0_1"/>
    <dbReference type="InParanoid" id="B8M5Z9"/>
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    <dbReference type="PhylomeDB" id="B8M5Z9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057684">
        <property type="entry name" value="DUF7924"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25545">
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7924" evidence="2">
        <location>
            <begin position="112"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="231"/>
        </location>
    </feature>
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        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED20126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="262" mass="30093" checksum="0672C24F7D9EFDD3" modified="2009-03-03" version="1">MSQRPSKRPRLQASDDSVSEDIALRERLLRQSVDIFQGTVFDDGAIERFHNALRNQSKSRLLTTYARFLVPSVEKQDLGEVSVLEDAIVVYNEKWLNVAPIYGPNPRPVVNMKNMHSMCIAMRAVWSLTSISNSMERIHRRILGFSISYDSERLQIYGHYPEIDDFDGILTANFSLFQEKGYGFTGKDLGTDRSLSYADKEVDKKTQEESIASQDLSESQNMFQTLQRQSDDREARYTKYLTASEQEIIGNTSRQKELLAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6J3</accession>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="441959.B8M6J3"/>
    <dbReference type="GeneID" id="8109668"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_027490"/>
    <dbReference type="eggNOG" id="ENOG502SQ9B">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019020_0_0_1"/>
    <dbReference type="InParanoid" id="B8M6J3"/>
    <dbReference type="OMA" id="AESDYGH"/>
    <dbReference type="OrthoDB" id="5399183at2759"/>
    <dbReference type="PhylomeDB" id="B8M6J3"/>
    <dbReference type="Proteomes" id="UP000001745">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED19455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="644" mass="70984" checksum="BEFD3D45A627255C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7J9</accession>
    <name>B8M7J9_TALSN</name>
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        <submittedName>
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    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479986.1">
        <property type="nucleotide sequence ID" value="XM_002479941.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479987.1">
        <property type="nucleotide sequence ID" value="XM_002479942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7J9"/>
    <dbReference type="FunCoup" id="B8M7J9">
        <property type="interactions" value="97"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M7J9"/>
    <dbReference type="GeneID" id="8108357"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_028410"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_21_2_1"/>
    <dbReference type="InParanoid" id="B8M7J9"/>
    <dbReference type="OMA" id="NDNVMRR"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035841">
        <property type="term" value="C:new growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035840">
        <property type="term" value="C:old growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903139">
        <property type="term" value="P:positive regulation of cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070610">
        <property type="term" value="P:regulation of fungal-type cell wall (1-&gt;3)-alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000573">
        <property type="entry name" value="RHO family GTPase Rho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED19552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="199" mass="22137" checksum="696B85DF025AC357" modified="2009-03-03" version="1">MAQQSTDNVMRRKLVIIGDGACGKTSLLSVFTLGYFPTHYVPTVFENYVTDCRVDGRSVQLALWDTAGQEDYERLRPLAYSKAHVLLIGFAVDTPDSLDNVKTKWIEEANERCPDVPIILVGLKKDLRDDPVAIEEMRKKSLRFLTPKEGSETAAQIGARKYLECSSLTGEGVDDVFEAATRAALLSFEKERNGCCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8A8</accession>
    <name>B8M8A8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_036460</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480855.1">
        <property type="nucleotide sequence ID" value="XM_002480810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8A8"/>
    <dbReference type="FunCoup" id="B8M8A8">
        <property type="interactions" value="1040"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M8A8"/>
    <dbReference type="GeneID" id="8101917"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_036460"/>
    <dbReference type="eggNOG" id="KOG1342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_0_3_1"/>
    <dbReference type="InParanoid" id="B8M8A8"/>
    <dbReference type="OMA" id="EHRWDKH"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="PhylomeDB" id="B8M8A8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10004">
        <property type="entry name" value="RPD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="11">
        <location>
            <begin position="39"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="438"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="620"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED20421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="672" mass="74307" checksum="9557186B65688EEC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8K8</accession>
    <name>B8M8K8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pogo transposable element, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_037410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480955.1">
        <property type="nucleotide sequence ID" value="XM_002480910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8K8"/>
    <dbReference type="GeneID" id="8100586"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_037410"/>
    <dbReference type="eggNOG" id="KOG3105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_4_0_1"/>
    <dbReference type="InParanoid" id="B8M8K8"/>
    <dbReference type="OrthoDB" id="4207519at2759"/>
    <dbReference type="PhylomeDB" id="B8M8K8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="61"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED20521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="610" mass="68951" checksum="373842CAADF8B2F7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8M976</accession>
    <name>B8M976_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">White collar, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_112070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481363.1">
        <property type="nucleotide sequence ID" value="XM_002481318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M976"/>
    <dbReference type="STRING" id="441959.B8M976"/>
    <dbReference type="GeneID" id="8098862"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_112070"/>
    <dbReference type="eggNOG" id="ENOG502QXB0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_947240_0_0_1"/>
    <dbReference type="InParanoid" id="B8M976"/>
    <dbReference type="OrthoDB" id="4225820at2759"/>
    <dbReference type="PhylomeDB" id="B8M976"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF9">
        <property type="entry name" value="PAS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0157">Chromophore</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="133"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED17371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="294" mass="33488" checksum="70B888A73EE241B8" modified="2009-03-03" version="1">MDNTSDHNSIIVEAQDSIDELRRRPSEYKLPFLQQANENNNNPSKIMEDNNSFMILLNSFKRVRARQPIEYANPVARLLMLLPDIESSDEHIPNARSPKLEQQAQNALHALSKFQGTSDALAEVFCLTDPSRLDNPIIFASEEFHRITQYGMEYVLGRNCRFLQGPKTNKHSKRRIRDVIEAGQQHHEVFLDYRRDGSPFMNLLMCAPLCDNNGKVRCFIGVDVSGLVMDDTRMDSIKGISASGHPSPNGQFEEDGDLAHQNGYTNGIHTMILRMQNHSIRRQLQKELEKPGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9C4</accession>
    <name>B8M9C4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable threonine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_114880</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481676.1">
        <property type="nucleotide sequence ID" value="XM_002481631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9C4"/>
    <dbReference type="FunCoup" id="B8M9C4">
        <property type="interactions" value="982"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M9C4"/>
    <dbReference type="GeneID" id="8101298"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_114880"/>
    <dbReference type="eggNOG" id="KOG1637">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008554_0_1_1"/>
    <dbReference type="InParanoid" id="B8M9C4"/>
    <dbReference type="OMA" id="WYADGMY"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="PhylomeDB" id="B8M9C4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000019">
        <property type="entry name" value="Threonine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000003">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000005">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="289"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED17684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="724" mass="83178" checksum="10DE9BC49261D583" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9H0</accession>
    <name>B8M9H0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE affecting a late Golgi compartment protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_115290</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481722.1">
        <property type="nucleotide sequence ID" value="XM_002481677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9H0"/>
    <dbReference type="FunCoup" id="B8M9H0">
        <property type="interactions" value="276"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M9H0"/>
    <dbReference type="GeneID" id="8101339"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_115290"/>
    <dbReference type="eggNOG" id="KOG3202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061883_0_0_1"/>
    <dbReference type="InParanoid" id="B8M9H0"/>
    <dbReference type="OMA" id="EHDPYRF"/>
    <dbReference type="OrthoDB" id="546861at2759"/>
    <dbReference type="PhylomeDB" id="B8M9H0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21444">
        <property type="entry name" value="SNARE_NTD_Tlg1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15851">
        <property type="entry name" value="SNARE_Syntaxin6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000012">
        <property type="entry name" value="SNARE domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000006">
        <property type="entry name" value="Syntaxin 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015260">
        <property type="entry name" value="Syntaxin-6/10/61_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048036">
        <property type="entry name" value="Tlg1p-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09177">
        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="14">
        <location>
            <begin position="162"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="107"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED17730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="254" mass="28714" checksum="2C11AC7A6A06EB85" modified="2009-03-03" version="1">MSEDPFLQVQSEVLNTLQTIRPLYSSFLRIRSLTTSPSNPELVQSRTELESTLEDLQADLADLRQSVRAVERDPYRYGLELDEVERRRGFVQDLGREVDDMVSEIGKQPAPTTAAKGKNNISLPNPSEFDTLSPDIHDKFDHHREEGEDDDYYANFEQQRQVDLMAAQDQQLDGVFRTVGNLRQQADTMGRELEDQAVLLDDVEGLADSVGGKLASGMKRIRTIVRKNEDTYSTCCIGILLVILVLLFILLLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9S5</accession>
    <name>B8M9S5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_118460</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Lipid-anchor</topology>
            <topology evidence="1 10">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482069.1">
        <property type="nucleotide sequence ID" value="XM_002482024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9S5"/>
    <dbReference type="FunCoup" id="B8M9S5">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M9S5"/>
    <dbReference type="GeneID" id="8099770"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_118460"/>
    <dbReference type="eggNOG" id="ENOG502QPST">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021855_2_1_1"/>
    <dbReference type="InParanoid" id="B8M9S5"/>
    <dbReference type="OMA" id="DDSIDFW"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="PhylomeDB" id="B8M9S5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF2">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 10" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005124074" description="1,3-beta-glucanosyltransferase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="12">
        <location>
            <begin position="371"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED18077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="539" mass="57249" checksum="1549559C4497C082" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9X6</accession>
    <name>B8M9X6_TALSN</name>
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        <submittedName>
            <fullName evidence="11">Polyketide synthase, putative</fullName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_118920</name>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
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    <dbReference type="EC" id="2.3.1.161" evidence="11"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482120.1">
        <property type="nucleotide sequence ID" value="XM_002482075.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M9X6"/>
    <dbReference type="GeneID" id="8108566"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_118920"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_31_4_1"/>
    <dbReference type="InParanoid" id="B8M9X6"/>
    <dbReference type="OMA" id="WEHKNNG"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="PhylomeDB" id="B8M9X6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050637">
        <property type="term" value="F:lovastatin nonaketide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
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        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF50">
        <property type="entry name" value="HIGHLY REDUCING POLYKETIDE SYNTHASE SRDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="50"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="983"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="983"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1130"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="1013"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED18128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="2388" mass="259340" checksum="FCBA5BFAAAAB556B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAC8</accession>
    <name>B8MAC8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sorbitol/xylulose reductase Sou1-like, putative</fullName>
            <ecNumber evidence="4">1.1.1.138</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_123610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.138" evidence="4"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002482577.1"/>
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    <dbReference type="AlphaFoldDB" id="B8MAC8"/>
    <dbReference type="STRING" id="441959.B8MAC8"/>
    <dbReference type="GeneID" id="8108272"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_123610"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="InParanoid" id="B8MAC8"/>
    <dbReference type="OMA" id="GAHFKKQ"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="PhylomeDB" id="B8MAC8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05352">
        <property type="entry name" value="MDH-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF3">
        <property type="entry name" value="MANNITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED18630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="308" mass="33469" checksum="6077BBE21A4FB1EB" modified="2009-03-03" version="1">MTIAFGLFNWVESKGGVVCHEHNQQHITSPFIFLLSSQQNIKMPVTVPTADSLKDLFSLKGKVIVITGASGPRGMGIESARGCAEMGANVAITYASRPEGGEKNARELAEKYGIKAKAYKCNVGKWEDVQKLVQDVIQEFGHIDGFVANAGRTADKGILDGSVKDWEEVIQTDLTGTFHCAKAVGPHFKQRGKGSFVITASMSGHIANFPQEQTSYNVAKAGCIHFARSLANEWRDFARVNSISPGYIDTGLSDFVPQETQDLWNSMIPLGRNGNAKELKGAYVYLLSDASTYTTGHDLVIDGGYTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAJ0</accession>
    <name>B8MAJ0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable E3 ubiquitin ligase complex SCF subunit sconB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Sulfur controller B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Sulfur metabolite repression control protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_112480</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the SCF(sconB) E3 ubiquitin ligase complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481406.1">
        <property type="nucleotide sequence ID" value="XM_002481361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAJ0"/>
    <dbReference type="FunCoup" id="B8MAJ0">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MAJ0"/>
    <dbReference type="GeneID" id="8105713"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_112480"/>
    <dbReference type="eggNOG" id="KOG0274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_103_3_1"/>
    <dbReference type="InParanoid" id="B8MAJ0"/>
    <dbReference type="OMA" id="TMCRAAQ"/>
    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="PhylomeDB" id="B8MAJ0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22147">
        <property type="entry name" value="F-box_SpPof1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051075">
        <property type="entry name" value="SCF_subunit_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872">
        <property type="entry name" value="UBIQUITIN LIGASE SPECIFICITY FACTOR/HREP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872:SF9">
        <property type="entry name" value="UBIQUITIN-BINDING SDF UBIQUITIN LIGASE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="14" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6 11" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="13">
        <location>
            <begin position="481"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="738"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="808"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="854"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="894"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="936"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="976"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="180"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="264"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="592"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="598"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED17414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1087" mass="120443" checksum="33956F2978310672" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAM0</accession>
    <name>B8MAM0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pogo transposable element, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_112760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481436.1">
        <property type="nucleotide sequence ID" value="XM_002481391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAM0"/>
    <dbReference type="GeneID" id="8105741"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_112760"/>
    <dbReference type="eggNOG" id="ENOG502S2ZX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_331808_0_0_1"/>
    <dbReference type="InParanoid" id="B8MAM0"/>
    <dbReference type="OrthoDB" id="4448936at2759"/>
    <dbReference type="PhylomeDB" id="B8MAM0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="6">
        <location>
            <begin position="367"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="148"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED17444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="863" mass="98452" checksum="DB0A737420C9A1A9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MB07</accession>
    <name>B8MB07_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_124320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482700.1">
        <property type="nucleotide sequence ID" value="XM_002482655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MB07"/>
    <dbReference type="GeneID" id="8098383"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_124320"/>
    <dbReference type="eggNOG" id="ENOG502ST9Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_657521_0_0_1"/>
    <dbReference type="InParanoid" id="B8MB07"/>
    <dbReference type="OMA" id="IRWAIEG"/>
    <dbReference type="OrthoDB" id="5244622at2759"/>
    <dbReference type="PhylomeDB" id="B8MB07"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="46907" checksum="1BD532B6EAED9EDC" modified="2009-03-03" version="1">MVESISPIKHRLELLERTLYAVQAQHRLLEYRVQYIEDENQTLRQALASSLQQGNGPGNGKASSGHNSYISELQALAKEPEDSVDEHVKTLSSLSLLDAPTLLMQVLVPKTTAKSEVRYSPLAPSSAAASEFEPSGGSRFNPPTVDTLPLVSGSPESSAVDTSSNPKTKERDFAVVPWDGTIAWKFINLFRDKREEHEAILNSIDHCRMQDEWFFQYGLRYIPKPGDKDAYRTVRIENLPNGTTLDELLAHIHCGDVFSADLLNTLSITGYHTGRVVFLHQKSAEKFCRSVKKRGLEIQGTPAHVTLEKTATYPVGMSLRAAIRDHGCTRCVLVDEVPEALIECIDGVVGTPHLKNSVEHYSRSYCDEEYPEQTKLRVCVRFHSMRAAAYAYDELQRNIFLRHCILTYDKDPCNSEPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8MB30</accession>
    <name>B8MB30_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Metalloprotease m41 ftsh, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_124540</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482723.1">
        <property type="nucleotide sequence ID" value="XM_002482678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MB30"/>
    <dbReference type="STRING" id="441959.B8MB30"/>
    <dbReference type="GeneID" id="8098405"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_124540"/>
    <dbReference type="eggNOG" id="KOG0743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010189_4_3_1"/>
    <dbReference type="InParanoid" id="B8MB30"/>
    <dbReference type="OMA" id="TVSCFGW"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="PhylomeDB" id="B8MB30"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="14">
        <location>
            <begin position="48"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="249"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED18731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="475" mass="53400" checksum="892A564E76AD0BE5" modified="2009-03-03" version="1">MAFYIHAGGAASRPLLEPCSQGYLLFKDVLTRFSKLDITQIGSLVAIAGVLPSAWRFLRHAWDETYSWVRHCFLASVTIPGGDPLNRSVVEWILANRPRNYRSFTGLTEVGNSGMDRAAALKKTRHPIRNAFLVERSSDSHSIAMSNNPGYDGIGGEELTISCFGWSVEPVKRFIKACRDYTETQTQFFVIIYSRDRYGLAWQPKARKPIRHLDTVHFDNQLKQDLLADIRNYLDPKTQKRYQTRSMPYRRGYLFYGPPGTGKSSLSLAIAGEFGLDLYEVKIPSVATDADLEQMFQDIPPRCVVLLEDIDAVWVDRSNSSKPVQDGQPMPNCTLSGLLNVLDGVGSQEGRIVIMTTNRPEALDSALTRPGRIDMKVYLGNISQKSSEEMFLRMFSPDLGFKFSFDMDEMRDLATSFASQIPDDKITPSALQGFFQQHLDSPHDAVSLIGGWVKEELAKKSDKEFEVIINNENAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8MB31</accession>
    <name>B8MB31_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">quinol--cytochrome-c reductase</fullName>
            <ecNumber evidence="3">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TSTA_124550</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="17">Binds 1 heme c group covalently per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482724.1">
        <property type="nucleotide sequence ID" value="XM_002482679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MB31"/>
    <dbReference type="FunCoup" id="B8MB31">
        <property type="interactions" value="688"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MB31"/>
    <dbReference type="GeneID" id="8098406"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_124550"/>
    <dbReference type="eggNOG" id="KOG3052">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040334_1_1_1"/>
    <dbReference type="InParanoid" id="B8MB31"/>
    <dbReference type="OMA" id="WVKKFKW"/>
    <dbReference type="OrthoDB" id="5925at2759"/>
    <dbReference type="PhylomeDB" id="B8MB31"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000002">
        <property type="entry name" value="Cytochrome c1, heme protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000003">
        <property type="entry name" value="Cytochrome c1, heme protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002326">
        <property type="entry name" value="Cyt_c1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021157">
        <property type="entry name" value="Cyt_c1_TM_anchor_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266">
        <property type="entry name" value="CYTOCHROME C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266:SF3">
        <property type="entry name" value="CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02167">
        <property type="entry name" value="Cytochrom_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00603">
        <property type="entry name" value="CYTOCHROMEC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81496">
        <property type="entry name" value="Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 17 18" id="KW-0349">Heme</keyword>
    <keyword evidence="13 17 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="20">
        <location>
            <begin position="97"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR602326-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EED18732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="317" mass="35171" checksum="4878A04F16099F70" modified="2009-03-03" version="1">MLARSLLRAAPARATARQSLRQNSRASSTSSGSENASSPFYLTATATVATAATIATTAWYYHLYGQQAFAMTPAEEGLHPSQYPWEHAKWNKTFDHQALRRGFQVYREVCASCHSLSRVPWRDFVGVMHTVDEMKAMAEENEYDTEPNDEGEIEKRPGKLSDYMPAPYKNDEAARAANNGALPPDLSLIVKARHGGCNYIFSLLTGYPDEPPAGASVQEGLNFNPYFPGTGIAMARVLFDGLVEYEDGTPATTSQMAKDVVEFLNWAAEPEMDERKKMGMKALALSAGLFAISVWVKRYKWAAIKARKIVYNPPVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBR4</accession>
    <name>B8MBR4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">SNF2 family helicase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSTA_119590</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482189.1">
        <property type="nucleotide sequence ID" value="XM_002482144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBR4"/>
    <dbReference type="STRING" id="441959.B8MBR4"/>
    <dbReference type="GeneID" id="8105234"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119590"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_2_5_1"/>
    <dbReference type="InParanoid" id="B8MBR4"/>
    <dbReference type="OMA" id="ETTVWRL"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="PhylomeDB" id="B8MBR4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF11">
        <property type="entry name" value="FAMILY HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G06590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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                <person name="Fedorova-Abrams N.D."/>
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</entry>
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        <location>
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        <location>
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        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="33091" checksum="0FD697DB83E219AD" modified="2009-03-03" version="1">MNSRGLISYADNMKEAVVKRRKTSRSSTGTRDANSETEADHSNDLLRKFFESRFQPLDMPTNQATTSQIYDDEDGENCGSEDDFEGFSDNESESEEEVMVVEHVDARKEDVLLDKQTRKALLSAKIPTSADLSASTNNKKDTKSKEEVDNETENLQNDLALQRLLKESHLLDSDSSDLNPTGKNRHKALDLRLLALGAKKSIFEQKKMPKSHREGIQSKAIKTETNRRREARENGIILEKPVFKQSKSSTKRRERGVGAPAVGKFSGGTLRLSKHDLASIQGPSRKAGRGGKKRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBZ0</accession>
    <name>B8MBZ0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell cycle control protein Cwf14/Bud31, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_121750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BUD31 (G10) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482428.1">
        <property type="nucleotide sequence ID" value="XM_002482383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBZ0"/>
    <dbReference type="FunCoup" id="B8MBZ0">
        <property type="interactions" value="885"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MBZ0"/>
    <dbReference type="GeneID" id="8098164"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_121750"/>
    <dbReference type="eggNOG" id="KOG3404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087132_1_1_1"/>
    <dbReference type="InParanoid" id="B8MBZ0"/>
    <dbReference type="OMA" id="FGTSCIC"/>
    <dbReference type="OrthoDB" id="277109at2759"/>
    <dbReference type="PhylomeDB" id="B8MBZ0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001748">
        <property type="entry name" value="BUD31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018230">
        <property type="entry name" value="BUD31/G10-rel_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411:SF0">
        <property type="entry name" value="PROTEIN BUD31 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411">
        <property type="entry name" value="PROTEIN BUD31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01125">
        <property type="entry name" value="BUD31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00322">
        <property type="entry name" value="G10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00997">
        <property type="entry name" value="G10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED18436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="148" mass="17261" checksum="C66D89D6396D15DB" modified="2009-03-03" version="1">MPPIRTTRNAKPPPAGFDDIEDTLLEFSNKMKDAENVSHEGKKRHEVLWPIFQISHQRSRYIYELYYEKEAISKQLYDWLLKNKYADAMLIAKWKKQGYEKLCCLRCIQTKETNFNSTCICRVPKAQLKEEQAIQCVSCGCRGCSSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCG9</accession>
    <name>B8MCG9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_125030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482777.1">
        <property type="nucleotide sequence ID" value="XM_002482732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCG9"/>
    <dbReference type="STRING" id="441959.B8MCG9"/>
    <dbReference type="GeneID" id="8100282"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_125030"/>
    <dbReference type="eggNOG" id="ENOG502SPA8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052870_0_0_1"/>
    <dbReference type="InParanoid" id="B8MCG9"/>
    <dbReference type="OrthoDB" id="4226919at2759"/>
    <dbReference type="PhylomeDB" id="B8MCG9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF4">
        <property type="entry name" value="FLUG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="427" mass="48072" checksum="74A8843414DBE871" modified="2009-03-03" version="1">MSTPQNTASSFINVSRWHMPPAEKSCGSWVGMPSSRMMLATKLSALDCQRGEPEVHEPGVAEVCSTRSSKCGASPAAPGTSPSGRWEHAPETGSVHSLRRTDQGAAPRYLPGPTDFGAQARKARVIEEMRSLAGTKKKAQKAFPHLYQRHESLCKELSQLRKTLAKDTKETARKEHFYNAPILEVDRQIKRLLSQADPEDCNVNSPDKKDWELPIPTYIFPERERLVDNFYGPDAESYEDDKLLARRIQATKDMVALSTLCEPNRRGDRVNWKFDDDESAELEKPCFLEEETLDCPTDRQDSLRRHLIDCHLAKAYDRIRCTWKMCHDVPKFTKIADFLAHAIYVHAYDVNIQLKHLPPRQPVSGREDSSSDDSDSSSDSNRHSGIDTPASSITSEITNTDPRLIESGSVHSTQCLVRRSKRIKVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8MD30</accession>
    <name>B8MD30_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Triglyceride lipase-cholesterol esterase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_113750</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481548.1">
        <property type="nucleotide sequence ID" value="XM_002481503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MD30"/>
    <dbReference type="FunCoup" id="B8MD30">
        <property type="interactions" value="1397"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MD30"/>
    <dbReference type="ESTHER" id="talsn-b8md30">
        <property type="family name" value="Acidic_Lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="8101687"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_113750"/>
    <dbReference type="eggNOG" id="KOG2624">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010974_5_0_1"/>
    <dbReference type="InParanoid" id="B8MD30"/>
    <dbReference type="OMA" id="WRMYNEI"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="PhylomeDB" id="B8MD30"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000095">
        <property type="entry name" value="Triglyceride lipase-cholesterol esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="9">
        <location>
            <begin position="83"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="486"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="495"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="514"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED17556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="533" mass="60554" checksum="AD7BA746B38F099B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8MD53</accession>
    <name>B8MD53_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_113930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481570.1">
        <property type="nucleotide sequence ID" value="XM_002481525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MD53"/>
    <dbReference type="STRING" id="441959.B8MD53"/>
    <dbReference type="GeneID" id="8109155"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_113930"/>
    <dbReference type="eggNOG" id="ENOG502SWVM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066658_0_0_1"/>
    <dbReference type="InParanoid" id="B8MD53"/>
    <dbReference type="OMA" id="FMQYDSV"/>
    <dbReference type="OrthoDB" id="5367275at2759"/>
    <dbReference type="PhylomeDB" id="B8MD53"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002875038" evidence="1">
        <location>
            <begin position="20"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="313" mass="35742" checksum="4ED3237D5B572A14" modified="2009-03-03" version="1">MVLLTSSTVATFLIPVITCQHGVRNIERDFRSLDSMQADYEHMTYDTNKEQSILDPETGELSTLNQGNFAYLQLLSEPNPASICSTIAIYKKMFEGGSTIQDRLFMYPQEWDLITPTDPVVSQALSSLREASVQYKFWLLPIDMHLVIQQGYSLTDSKLLRLGEIQFMAYDSVLYLRTPGLLLDAQELDKMILTRPLPMKYEPTRQESYRNAAWIGMPLRAHNEAKIPPVYLISVNSMRNRVEARTHVPNVALRGFGDLAAGPNFVKVTGKDPAYVFFDWDEDGRIQQENNTYYDRWRQESANVCGGLDLSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDF9</accession>
    <name>B8MDF9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glucose dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_117080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481914.1">
        <property type="nucleotide sequence ID" value="XM_002481869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MDF9"/>
    <dbReference type="STRING" id="441959.B8MDF9"/>
    <dbReference type="GeneID" id="8102100"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_117080"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_3_1"/>
    <dbReference type="InParanoid" id="B8MDF9"/>
    <dbReference type="OMA" id="WLTFQNK"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="PhylomeDB" id="B8MDF9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF134">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="497"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="541"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="93"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="496"/>
            <end position="497"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED17922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="563" mass="62313" checksum="7E32047E8720B129" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDM8</accession>
    <name>B8MDM8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_120110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482249.1">
        <property type="nucleotide sequence ID" value="XM_002482204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MDM8"/>
    <dbReference type="STRING" id="441959.B8MDM8"/>
    <dbReference type="GeneID" id="8105285"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_120110"/>
    <dbReference type="eggNOG" id="ENOG502SUI3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096188_2_2_1"/>
    <dbReference type="InParanoid" id="B8MDM8"/>
    <dbReference type="OMA" id="FGVIQIH"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="PhylomeDB" id="B8MDM8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02231">
        <property type="entry name" value="cupin_BLL6423-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047142">
        <property type="entry name" value="OryJ/VirC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156:SF2">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156">
        <property type="entry name" value="SLR2101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="83"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="181" mass="19861" checksum="91A97C3635D6AD52" modified="2009-03-03" version="1">MTNLSTPIRRVLTASDPKGNGYFASDDLLTPYDPTTAPEFSLPTEKSAFGVIQLHRTRGFPADNQRPTLVPLADTKGPSARIIDLPPHQEGGWMHRTLSLDYCVVLSGSVTFITDGGEEKTLKEHDVIVTRGVNHAWVNRGETVARVFAVVVPALPIITEDRVQLDKTPAGEIFDPEEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEC8</accession>
    <name>B8MEC8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_016340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483789.1">
        <property type="nucleotide sequence ID" value="XM_002483744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEC8"/>
    <dbReference type="STRING" id="441959.B8MEC8"/>
    <dbReference type="GeneID" id="8106407"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_016340"/>
    <dbReference type="eggNOG" id="ENOG502RZVD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022564_2_0_1"/>
    <dbReference type="InParanoid" id="B8MEC8"/>
    <dbReference type="OMA" id="WTKSRIR"/>
    <dbReference type="OrthoDB" id="5378975at2759"/>
    <dbReference type="PhylomeDB" id="B8MEC8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031355">
        <property type="entry name" value="YBL010C/LAA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17104">
        <property type="entry name" value="YBL010C_LAA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="529" mass="57582" checksum="99FB221AEF83530E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEM7</accession>
    <name>B8MEM7_TALSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_019710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_019710"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2689650_0_0_1"/>
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    <dbReference type="OrthoDB" id="5409193at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="78" mass="8565" checksum="FE9EEF02C072AD53" modified="2009-03-03" version="1">MSQPTGTTTTQERSQPWQAMQEVQTLFKPAMSAANAESGADASSQRDMLGEKPLKLNLFRENLNSATTNIADVVEEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEN4</accession>
    <name>B8MEN4_TALSN</name>
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        <submittedName>
            <fullName evidence="1">Phosphatidylethanolamine-binding protein, putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">TSTA_019780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED16917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="441959.B8MEN4"/>
    <dbReference type="GeneID" id="8104937"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_019780"/>
    <dbReference type="eggNOG" id="KOG3346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043994_7_0_1"/>
    <dbReference type="InParanoid" id="B8MEN4"/>
    <dbReference type="OMA" id="LHWIQSD"/>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="PhylomeDB" id="B8MEN4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030162">
        <property type="term" value="P:regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF78">
        <property type="entry name" value="PROTEASE INHIBITOR"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED16917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="185" mass="20606" checksum="0159E4053FA6641D" modified="2009-03-03" version="1">MPSYKNIDKYLDQIHKDKTLVLGLVVGSHQDVKPGVRIPKADAQSSPELHLPKSYLSSSTTNDTYLMIAIDIDAPFPSWRGLGPILHWVQPNLKPDPVTGRLSPPGPESYIVNYIGPAPPPPSSPHRYCFFLYRQPEGLDVDKYIAKRGGKKVGNVARMWFDLEKHERELGLKGGIVAGNYFVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8MET5</accession>
    <name>B8MET5_TALSN</name>
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        <submittedName>
            <fullName evidence="9">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="ORF">TSTA_020260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484202.1">
        <property type="nucleotide sequence ID" value="XM_002484157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MET5"/>
    <dbReference type="STRING" id="441959.B8MET5"/>
    <dbReference type="GeneID" id="8108837"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_020260"/>
    <dbReference type="eggNOG" id="ENOG502S5NV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_465529_0_0_1"/>
    <dbReference type="InParanoid" id="B8MET5"/>
    <dbReference type="OMA" id="KEATCVD"/>
    <dbReference type="OrthoDB" id="5575144at2759"/>
    <dbReference type="PhylomeDB" id="B8MET5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="188"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="58"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="360"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="459"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="535"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED16968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="586" mass="63842" checksum="F62409F9AC3FDFF3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEY7</accession>
    <name>B8MEY7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_023240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484504.1">
        <property type="nucleotide sequence ID" value="XM_002484459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEY7"/>
    <dbReference type="STRING" id="441959.B8MEY7"/>
    <dbReference type="GeneID" id="8109976"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_023240"/>
    <dbReference type="eggNOG" id="KOG0351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004144_0_0_1"/>
    <dbReference type="InParanoid" id="B8MEY7"/>
    <dbReference type="OMA" id="AVENCHS"/>
    <dbReference type="OrthoDB" id="5153301at2759"/>
    <dbReference type="PhylomeDB" id="B8MEY7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF154">
        <property type="entry name" value="RECQ HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="594"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="786"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="959"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="962"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED17270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1026" mass="117316" checksum="BA1EB1B96B7ED52F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8MF36</accession>
    <name>B8MF36_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinesin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_012440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483369.1">
        <property type="nucleotide sequence ID" value="XM_002483324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MF36"/>
    <dbReference type="STRING" id="441959.B8MF36"/>
    <dbReference type="GeneID" id="8104092"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_012440"/>
    <dbReference type="eggNOG" id="KOG1840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_125_3_1"/>
    <dbReference type="InParanoid" id="B8MF36"/>
    <dbReference type="OMA" id="LVSTYWA"/>
    <dbReference type="OrthoDB" id="4218961at2759"/>
    <dbReference type="PhylomeDB" id="B8MF36"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877573" evidence="1">
        <location>
            <begin position="23"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="355"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED16135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1192" mass="134355" checksum="7A28E08910526949" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFT1</accession>
    <name>B8MFT1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_009220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483032.1">
        <property type="nucleotide sequence ID" value="XM_002482987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFT1"/>
    <dbReference type="GeneID" id="8100783"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_009220"/>
    <dbReference type="eggNOG" id="ENOG502SESV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029138_1_0_1"/>
    <dbReference type="InParanoid" id="B8MFT1"/>
    <dbReference type="OMA" id="REHWAIN"/>
    <dbReference type="OrthoDB" id="2548233at2759"/>
    <dbReference type="PhylomeDB" id="B8MFT1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034:SF1">
        <property type="entry name" value="CONDENSATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED15798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="52351" checksum="3E68F0E3A18F8EB7" modified="2009-03-03" version="1">MAWHEPNLKSVSNTIMPWSRVDDNRYERALGENETFIKILADAARPLNREHWAINIITTVTPMGSIAQEDLTSLFREAWKGLRFKHPTIAAYVMDETKYVYDVPDKTALTEWATETFRVVDNKTVDEVIASTTLNPYATMTYFPQTCQLLGHAQHWRTDGVGGFILMDDFLDLASRSVPVDASSLPWGEETSRLAPSIEEAAGLLSADPSEEDKKLAQQAVAGFGHTVGAIGIASDAAAETVPGGTRISCLQLSEQETNAVVKACKDKQISVTAAVHASVAGANYALAAPEDKNKHYTSTIRFSFRPFLPKPYSGREYASAIFTSGWMFPVTAESSWAERAKAYHDEYRKGLTPEFISAHREYAIGLCNLLQSMPAGLPSPTDVDISSLGVVERMLAREKGTPERGIHIDQVSGGLEMANRQCVCHVWTFRNELCLNLVYNEAFYEKATMDTFVGSVKDLLLQGLSVKLIQPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MG94</accession>
    <name>B8MG94_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vanillin dehydrogenase, putative</fullName>
            <ecNumber evidence="7">1.2.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_013200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="7"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483448.1">
        <property type="nucleotide sequence ID" value="XM_002483403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MG94"/>
    <dbReference type="STRING" id="441959.B8MG94"/>
    <dbReference type="GeneID" id="8108196"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_013200"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_1"/>
    <dbReference type="InParanoid" id="B8MG94"/>
    <dbReference type="OMA" id="NWYGFNV"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="PhylomeDB" id="B8MG94"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07105">
        <property type="entry name" value="ALDH_SaliADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000012">
        <property type="entry name" value="NAD-dependent succinate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF6">
        <property type="entry name" value="CYTOPLASMIC ALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="28"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED16214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="484" mass="51670" checksum="AA4E794747B7E81C" modified="2009-03-03" version="1">MENGASVLGHVPVIPLLIDNESIVTDVKFDVVSPLNNQCCYQSSSASVAEANAAAQAAQAAFSQWTKLKPNVRRELLWKAADLMDSVSDELVRYQQEEMGALPAAARRSIKRASDLLRDAGAMISLIEGTVPSLGQEGYAAVVLKEPYGVVLGIAPWNSPFILGMRAIALPLAAGNTVILKGSELSPKCFWALGQIFYRAGLPKGCVNVIFHRPSDAIEVTNSLIAHPAVQKINFTGSTQVGRAIAAVAGKYGKPVLLELGGKAPCIILDDADLQEAASGCLIGAFAGAGQICMSTERIIVHRRVAESFRAILVEKAQEMFGASLPVPTLVSAASRKRIQILVSDALQKKAEKLFAPRDNKEQNDSQMQPIILENVSPDSDLYHTESFGPVASLFVVDSEGEAIELANDTEYGLTAAVYTNNLARGFMVAGQIQSGAVHINSPTIHDEPVLPHGGVRSSGYGRFGGVHGLDEFLQTKVITWKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8MH80</accession>
    <name>B8MH80_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Beta-xylanase</fullName>
            <ecNumber evidence="13">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSTA_019560</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="13"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484128.1">
        <property type="nucleotide sequence ID" value="XM_002484083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MH80"/>
    <dbReference type="STRING" id="441959.B8MH80"/>
    <dbReference type="GeneID" id="8104651"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_019560"/>
    <dbReference type="eggNOG" id="ENOG502QR4K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020161_12_1_1"/>
    <dbReference type="InParanoid" id="B8MH80"/>
    <dbReference type="OMA" id="CVGFTIW"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
    <dbReference type="PhylomeDB" id="B8MH80"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031158">
        <property type="entry name" value="GH10_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF35">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00591">
        <property type="entry name" value="GH10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10 13 18" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 13 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <keyword evidence="6 18" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002875109" description="Beta-xylanase" evidence="15">
        <location>
            <begin position="20"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="17">
        <location>
            <begin position="24"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="16">
        <location>
            <begin position="370"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="341"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EED16894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="406" mass="43144" checksum="FB84CD7918633B18" modified="2009-03-03" version="1">MVAVKPLILALAAGHLAHAQLNTAAKAAGLLYFGTAVDNGDLSDSQYLPNLETDDFGQITPANSMKWQPTEPSQGSYTFSQGDQIASLAKTNNDYLRCHNLVWYNQLPSYITSGSWTNETLIAALKEHINGVVTHWKGQCYAWDVVNEALNEDGTYRQNVFYQHIGEAYIPIAFAAAAAADPNAKLYYNDYNIEYPGAKATGAQNIVKSIQAAGARIDGVGLQAHFIVGQTPSLASQKANMAAFTALGVDVAITELDIRMTLPDTSALQTQQSTDYQTTTTACVQTKGCVGITLWDFTDKHSWVPGTFSGQGDACPWDSNYKKKPAYYGILAGLQSGAGGSTTLTTTTTSTPTTTSSPATTTTTGAGSGTGAAHWGQCGGNGWTGPTTCVSPYTCQVVNPYYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8MI58</accession>
    <name>B8MI58_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain dehydrogenase/reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_022740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484454.1">
        <property type="nucleotide sequence ID" value="XM_002484409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MI58"/>
    <dbReference type="STRING" id="441959.B8MI58"/>
    <dbReference type="GeneID" id="8107111"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_022740"/>
    <dbReference type="eggNOG" id="KOG4169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_13_3_1"/>
    <dbReference type="InParanoid" id="B8MI58"/>
    <dbReference type="OMA" id="MYTTHLA"/>
    <dbReference type="OrthoDB" id="5371740at2759"/>
    <dbReference type="PhylomeDB" id="B8MI58"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF16">
        <property type="entry name" value="BACILYSIN BIOSYNTHESIS OXIDOREDUCTASE BACC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED17220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="375" mass="40541" checksum="8BA60C8D8FF779BA" modified="2009-03-03" version="1">MDLSYDTARIKGKTILITGGASGFGAGYGARWAAAGANVILGDINPAGEEVAAQIRQDTQNENVHFIQLDVTSWKSQVNFFRESVRLSPHGGIDTVVANAGINNSEESRSFENPHVDYLNDPSPPAPSFKTLDVNLTGVMYTVHLALFFLPKNPGSMPCEQESVASESGRDRHILLMGSVASLHPLITQAPYTVSKHGVLGLFRSLRVTAPVSAGVRVNIICPYYTDSTFMQTPVRVLLAGVPLGKSEDVIDAASYLVADTACIGRSLVTGPKLKLDYSTGEFEALHDGNDKEGAVWECYLNDSDPADIFTQRMLTVVHAAVKARGWAGWVSGMAECELPVTALSTVSLRLGNMRLLATWRSFPYKEAEHEAIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIZ3</accession>
    <name>B8MIZ3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_050930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485608.1">
        <property type="nucleotide sequence ID" value="XM_002485563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIZ3"/>
    <dbReference type="GeneID" id="8109135"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_050930"/>
    <dbReference type="eggNOG" id="ENOG502SC13">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060131_6_5_1"/>
    <dbReference type="InParanoid" id="B8MIZ3"/>
    <dbReference type="OMA" id="FEVMHIM"/>
    <dbReference type="OrthoDB" id="2744543at2759"/>
    <dbReference type="PhylomeDB" id="B8MIZ3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="256" mass="29513" checksum="39A2340EBA064BB4" modified="2009-03-03" version="1">MFERSFTQNMGMKDIKVRPATVEDATSISQIHYEALGKFHKFYSGFLANNPREIIPITTATALKDPKSAFLVAVDTATDRIVGFIRYWIVKEEKNEAEMTAKKSQLDRSQPEFTNLFAPKEHVKKLYEEFSVRDDEMDACYEEVAKGQRHYYIKHLMIDPAQQRRGIGQKLLSAVLAKSDAENLPTFLTSSTEAHPLYVKLGFVDIGPEFRIDNEAWASRIMELEREIGVDERMRLKDECVGLYEVENCMVRWASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJF4</accession>
    <name>B8MJF4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_046080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485107.1">
        <property type="nucleotide sequence ID" value="XM_002485062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJF4"/>
    <dbReference type="STRING" id="441959.B8MJF4"/>
    <dbReference type="GeneID" id="8098335"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_046080"/>
    <dbReference type="HOGENOM" id="CLU_515036_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJF4"/>
    <dbReference type="OrthoDB" id="4227234at2759"/>
    <dbReference type="PhylomeDB" id="B8MJF4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="211"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="448"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED15154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="529" mass="60025" checksum="117173E696429027" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MK33</accession>
    <name>B8MK33_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin synthase export chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_043250</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CHS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484803.1">
        <property type="nucleotide sequence ID" value="XM_002484758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MK33"/>
    <dbReference type="FunCoup" id="B8MK33">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MK33"/>
    <dbReference type="GeneID" id="8104967"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_043250"/>
    <dbReference type="eggNOG" id="ENOG502QRVH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050424_1_1_1"/>
    <dbReference type="InParanoid" id="B8MK33"/>
    <dbReference type="OMA" id="TVWEVKD"/>
    <dbReference type="OrthoDB" id="2189463at2759"/>
    <dbReference type="PhylomeDB" id="B8MK33"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF2">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED14850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="332" mass="36551" checksum="ADF5CD72E4199B36" modified="2009-03-03" version="1">MTGITSLDSFCRTAPVPLCALIGPKSSIQGSNGILPTCYARNIDVGNTIIFQGASDFAHIAALMMTVIMILHVRSKFTAVGRKEITDFFYLFMLLTVCSLVVDAGVVPPHSGPFPWFVAAQNGLVSATCTCLLINGFVGFQLYEDGTNLSVWLLRASSAGMFVISFIVSLFTFKGWGGLDPENPIGLFVVIYILNAICLAIYVVMQLLLVYNTLDDRWPLGHIALGVFFFVVGQVMVYALSTTICNGVQHYLDGLFFGTVCNLFAVMMIYKYWDSITKEDLEFSVGVKSNNWDIKDIQEEDRRLTIYPDGGSEYAPSTHYRSSTFGGNHSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8MK51</accession>
    <name>B8MK51_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_043430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484821.1">
        <property type="nucleotide sequence ID" value="XM_002484776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MK51"/>
    <dbReference type="GeneID" id="8097851"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_043430"/>
    <dbReference type="HOGENOM" id="CLU_672972_0_0_1"/>
    <dbReference type="InParanoid" id="B8MK51"/>
    <dbReference type="OrthoDB" id="10535462at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002875174" evidence="2">
        <location>
            <begin position="20"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED14868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="409" mass="42354" checksum="C86F57DB034F6D5B" modified="2009-03-03" version="1">MKSASILPFLCVLAAAAPAFSIPGREVDVHRRQSTDDDGLGDLLGGVRARQSSDDDDDDDGLGGLLGGLRARQSSDDDDAGLDDVLGGLKRRQSSNTPNDFGNVLSDLPTRQNSDSDNNSNDDSLGNILDDSSLSVDGNGQNVDIADLGSLLRRQLLPAPSTSSTSGNNDNSDQLANVLDGSAADINRNAQNVSVARRQFPSKSENGNGNGDDNESLLNVLDGDTGDVNRNIQNITVLRRTSSKQSVGKRGWLSALLGRDTPSTTNNGNGNGDNDESLANVLDGSAAAVDDNVQGVSVLRRQASSSSATPSPTPSASAAPIVQDPTLNAANDNDNNNASNNDALLNAADDSSADVSKNLQNITILKHRRQNAGDKNGDVDDDDTLGNIVDGSAVKADGNAEGVDVGDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKN6</accession>
    <name>B8MKN6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent RNA helicase SUB2</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ATP-dependent RNA helicase sub2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">TSTA_048330</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 also plays a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the DEAD box helicase family. DECD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485344.1">
        <property type="nucleotide sequence ID" value="XM_002485299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKN6"/>
    <dbReference type="FunCoup" id="B8MKN6">
        <property type="interactions" value="1242"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MKN6"/>
    <dbReference type="GeneID" id="8107015"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_048330"/>
    <dbReference type="eggNOG" id="KOG0329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8MKN6"/>
    <dbReference type="OMA" id="YAHVEPK"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="PhylomeDB" id="B8MKN6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17950">
        <property type="entry name" value="DEADc_DDX39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000111">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000168">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase 56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 23" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="22">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="92"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="21">
        <location>
            <begin position="279"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="18">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EED15391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="444" mass="49936" checksum="5CC06281B9F5D996" modified="2009-03-03" version="1">MATEEDLIDYSDEELQTTEPAAVAPAATEAGNGAAATKKGDLTVSGGRPDKKGSYVGIHSTGFRDFLLKTELLRAITDCGFEHPSEVQQVCIPQGMLHSDLLCQAKSGLGKTAVFVLTTLHGLDPVEGEVQVLVMCHTRELAYQIKNEYARFSKYLPQVKTAVFYGGTPMQKDIEILSNKETRPNIVVGTPGRLNALVRDKKLSLRNVKAFVLDECDKMLDQIDMRRDVQEIFRNTPAEKQVMMFSATLSQEVRPICKKFMRNPLEVYVDDDTKLTLHGLQQYYIKLSEQEKNRKLSDLLDNLEFNQVIIFVKSTLRANELDKLLRECNFPSIAVHSGVSQEERIKRYKEFKEFNKRICVATDVFGRGIDIERINLAINYDLPGDADSYLHRVGRAGRFGTKGLSISFVSSEEDEKVLKEIEKRFEVALPEYPEGGVDASTYMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKQ2</accession>
    <name>B8MKQ2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome segregation protein (SepB), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_043720</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484854.1">
        <property type="nucleotide sequence ID" value="XM_002484809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKQ2"/>
    <dbReference type="FunCoup" id="B8MKQ2">
        <property type="interactions" value="349"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MKQ2"/>
    <dbReference type="GeneID" id="8097880"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_043720"/>
    <dbReference type="eggNOG" id="KOG1274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004219_2_1_1"/>
    <dbReference type="InParanoid" id="B8MKQ2"/>
    <dbReference type="OMA" id="RYAHTNG"/>
    <dbReference type="OrthoDB" id="427368at2759"/>
    <dbReference type="PhylomeDB" id="B8MKQ2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057646">
        <property type="entry name" value="WD40_WDHD1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022100">
        <property type="entry name" value="WDHD1/CFT4_beta-prop_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048591">
        <property type="entry name" value="WDHD1/CFT4_hel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932:SF10">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20946">
        <property type="entry name" value="Ctf4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12341">
        <property type="entry name" value="Mcl1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24817">
        <property type="entry name" value="WD40_WDHD1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDHD1 first WD40" evidence="9">
        <location>
            <begin position="11"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="11"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="229"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 second beta-propeller" evidence="7">
        <location>
            <begin position="416"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 helical bundle" evidence="8">
        <location>
            <begin position="727"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="323"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED14901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="841" mass="94504" checksum="C1A3C39AB3DA4D6F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKW6</accession>
    <name>B8MKW6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor (AmyR), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_044310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484918.1">
        <property type="nucleotide sequence ID" value="XM_002484873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKW6"/>
    <dbReference type="STRING" id="441959.B8MKW6"/>
    <dbReference type="GeneID" id="8104107"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_044310"/>
    <dbReference type="eggNOG" id="ENOG502RZG2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016574_6_2_1"/>
    <dbReference type="InParanoid" id="B8MKW6"/>
    <dbReference type="OrthoDB" id="4132249at2759"/>
    <dbReference type="PhylomeDB" id="B8MKW6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF19">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED14965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="693" mass="78376" checksum="10004850EEC82FE6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLG4</accession>
    <name>B8MLG4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn cluster transcription factor Rds2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_049340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485450.1">
        <property type="nucleotide sequence ID" value="XM_002485405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLG4"/>
    <dbReference type="FunCoup" id="B8MLG4">
        <property type="interactions" value="396"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MLG4"/>
    <dbReference type="GeneID" id="8100650"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_049340"/>
    <dbReference type="eggNOG" id="ENOG502QQGC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010748_0_0_1"/>
    <dbReference type="InParanoid" id="B8MLG4"/>
    <dbReference type="OMA" id="TRCVKRN"/>
    <dbReference type="OrthoDB" id="65716at2759"/>
    <dbReference type="PhylomeDB" id="B8MLG4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045722">
        <property type="term" value="P:positive regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053045">
        <property type="entry name" value="Zinc_cluster_trans_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31986">
        <property type="entry name" value="REGULATOR OF DRUG SENSITIVITY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31986:SF7">
        <property type="entry name" value="REGULATOR OF DRUG SENSITIVITY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ERT1/acuK family PAS" evidence="7">
        <location>
            <begin position="337"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="192"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED15497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="449" mass="50279" checksum="CF50565A40F924DD" modified="2009-03-03" version="1">MTCDSERPCTRCIKRNIGHLCHDEPREPAKKNNRTEPEDGAAAIGNGNEFASSHNLATDAGNQSMLSDSSLSIRPSTIDPSQSVQSATIQPAAGQGLDRNNQHMFGYNAGGAGSGDWGLNGQSNGFQDMHTFHPSYMFNAPEVTNEYNLLGDFLNNSLLDDNGMYGNEELQGMFSDSSLINMSTNINPNAASFAQQQQQQQQLAQLAPQQATNTQIQQPTSSVSTDKARENYYMTAADPSGMDPPEERMNKLLKAKYEAGMLRPFNYVKGYARLNQYMESHMKPASRHKILRQLDKFRPKFRERMQSLTDIELVFSEMWFERSLMEYDRVFASMAIPACCWRRTGEIFRGNKEMAELINVPIESLRDGKLALHQIITEDQLVSYWEKFGAIAFDGSQKAMLTSCTLKSPDDDDSAKGIPCCFSFTIRRDPNAIPALIVGNFLPSERRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLJ7</accession>
    <name>B8MLJ7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex protein EXO70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_049680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Bud</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EXO70 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485483.1">
        <property type="nucleotide sequence ID" value="XM_002485438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLJ7"/>
    <dbReference type="FunCoup" id="B8MLJ7">
        <property type="interactions" value="118"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MLJ7"/>
    <dbReference type="GeneID" id="8102128"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_049680"/>
    <dbReference type="eggNOG" id="KOG2344">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010236_4_2_1"/>
    <dbReference type="InParanoid" id="B8MLJ7"/>
    <dbReference type="OMA" id="GIIRAGP"/>
    <dbReference type="OrthoDB" id="1922221at2759"/>
    <dbReference type="PhylomeDB" id="B8MLJ7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004140">
        <property type="entry name" value="Exo70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542:SF41">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542">
        <property type="entry name" value="EXOCYST COMPLEX PROTEIN EXO70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" value="Exo70_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20669">
        <property type="entry name" value="Exo70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="5">
        <location>
            <begin position="245"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED15530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="627" mass="69037" checksum="5BA191AC54B67EC1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMF4</accession>
    <name>B8MMF4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pogo transposable element, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_099590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485946.1">
        <property type="nucleotide sequence ID" value="XM_002485901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMF4"/>
    <dbReference type="GeneID" id="8105402"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_099590"/>
    <dbReference type="eggNOG" id="ENOG502S2ZX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_4_0_1"/>
    <dbReference type="InParanoid" id="B8MMF4"/>
    <dbReference type="OMA" id="CCEAHIQ"/>
    <dbReference type="OrthoDB" id="8194222at2759"/>
    <dbReference type="PhylomeDB" id="B8MMF4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED13708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="490" mass="56328" checksum="FD98F5215169A2A7" modified="2009-03-03" version="1">MAYRAETRANGHKLTQSEEESLVRWILDLDKRGLPPRHSLVREMADYLLSQRGNQYVGENWEYNLVKRRPEIESKFSRKYNYERAKCEDPKIVQEYFDRVREVILEYGILPEDIYNFDETGFAMGLCATAKVITGSDRYNRPNILQPGDREWVTAIEAVNSIGWALPSYIIFKAKKYTRLGWFEDLPDDWKINISDNGWTTDKIGLEWLKTHFIPLIDGRTSGKYWMLILDGHGSHLTAEFDHTCTKNNIIPVCMPPHSSHLLQPLDVGCFAVLKRHYGQLVEQRMRLGFNHIDKLDFLTAFPKARTMVYKAQTVRNSFTATGLLTVRLKTPTPPPSRSSDTQSSCLQTPQNPRQFKRQMTTMKKRISWHTRSSSKAIGEVFTRASKAYEMSINKLTIAQKELHDLRAAHEKEKQKRQKSKKQISHDHGITREEAQALVQGQIEASQTVTTAPAEPELPVSHLPVRRQFRCSGCGIEGHKITGCPNRARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8MND1</accession>
    <name>B8MND1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_102500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486258.1">
        <property type="nucleotide sequence ID" value="XM_002486213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MND1"/>
    <dbReference type="GeneID" id="8100827"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_102500"/>
    <dbReference type="eggNOG" id="ENOG502RK0Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060983_2_1_1"/>
    <dbReference type="InParanoid" id="B8MND1"/>
    <dbReference type="OMA" id="QNTRATH"/>
    <dbReference type="OrthoDB" id="3012298at2759"/>
    <dbReference type="PhylomeDB" id="B8MND1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF60">
        <property type="entry name" value="III CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002875249" description="GH18 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="34"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED14020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="313" mass="34252" checksum="76608B458558DFAC" modified="2009-03-03" version="1">MLHKLLAPLIALLSLSQYVLSFPLTVRLDNGAPLRNIVYVQTFTDSRGNWFNLTDLVTQKSGITHVILASLHLDSPTEIHLNDNDIESSYWDPLWPMVSSLQAAGVKVMLMMGGAAQGSYARLQNDFDTYYPIILQILRHHNLDGFDMDVEENVSESILLRLAQQLDADMGTNFILTAAPVALSMSNSGNLDNVSWPALDKVAISSTRPNGKLFNWYNTQFYDGWGSAASTGSYDTVIKAGWDPRRIVLGVLTAASAGSSWQPTSVLASTIASLKAKYPNFGGVFGWEYGLAGQSDGQTPVQWVQSIGRYLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNN1</accession>
    <name>B8MNN1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uracil permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_103430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486358.1">
        <property type="nucleotide sequence ID" value="XM_002486313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNN1"/>
    <dbReference type="GeneID" id="8103046"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_103430"/>
    <dbReference type="eggNOG" id="KOG2466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021555_3_2_1"/>
    <dbReference type="InParanoid" id="B8MNN1"/>
    <dbReference type="OMA" id="CISAWST"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="PhylomeDB" id="B8MNN1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF15">
        <property type="entry name" value="NICOTINAMIDE RIBOSIDE TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED14120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="576" mass="64063" checksum="443D308EC520F01E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNN2</accession>
    <name>B8MNN2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_103440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486359.1">
        <property type="nucleotide sequence ID" value="XM_002486314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNN2"/>
    <dbReference type="STRING" id="441959.B8MNN2"/>
    <dbReference type="GeneID" id="8103047"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_103440"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_277211_0_0_1"/>
    <dbReference type="InParanoid" id="B8MNN2"/>
    <dbReference type="OMA" id="KHATEYW"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="PhylomeDB" id="B8MNN2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="8">
        <location>
            <begin position="324"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="7">
        <location>
            <begin position="635"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="6">
        <location>
            <begin position="897"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED14121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1145" mass="125663" checksum="E8D4D118C26D94BF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8MP07</accession>
    <name>B8MP07_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">C6 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_104600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486484.1">
        <property type="nucleotide sequence ID" value="XM_002486439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MP07"/>
    <dbReference type="STRING" id="441959.B8MP07"/>
    <dbReference type="GeneID" id="8103231"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_104600"/>
    <dbReference type="eggNOG" id="ENOG502S69E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038300_1_0_1"/>
    <dbReference type="InParanoid" id="B8MP07"/>
    <dbReference type="OrthoDB" id="3251668at2759"/>
    <dbReference type="PhylomeDB" id="B8MP07"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED14246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="245" mass="27978" checksum="F8FAF4C1FC34BECF" modified="2009-03-03" version="1">MRGVPWTMHLEGIYNILCAQGFQNMNRENESFRNHLVEVMGVMDMSVFILGRQTPYFGIWRQHRHGPVNMSKQGDVETVTGLPRSLLDLYSGIGETTSEQDLWNWPGEKGNLLQCQLWEAHRLSAILNRAVAHRIEHRHRNPCHAHSQLSDAILRAHIDMDKEAEENQVVNALNYPALIAAQEVEILRNNPDSMSLIRRCLQSHSKAGFGSKLLLNLLVEFWEFNDPNLDLDSLASFHHVEAGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MP65</accession>
    <name>B8MP65_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">TSTA_105160</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486542.1">
        <property type="nucleotide sequence ID" value="XM_002486497.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B8MP65">
        <property type="interactions" value="610"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MP65"/>
    <dbReference type="GeneID" id="8098737"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_105160"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001650_18_4_1"/>
    <dbReference type="InParanoid" id="B8MP65"/>
    <dbReference type="OrthoDB" id="4356562at2759"/>
    <dbReference type="PhylomeDB" id="B8MP65"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="20" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="25">
        <location>
            <begin position="607"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="241"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="927"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1017"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="957"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1019"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1042"/>
            <end position="1067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EED14304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1649" mass="189672" checksum="ED4206C93E2EA559" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPB7</accession>
    <name>B8MPB7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_105670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486594.1">
        <property type="nucleotide sequence ID" value="XM_002486549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPB7"/>
    <dbReference type="GeneID" id="8100426"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_105670"/>
    <dbReference type="eggNOG" id="ENOG502S2D3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051862_0_0_1"/>
    <dbReference type="InParanoid" id="B8MPB7"/>
    <dbReference type="OMA" id="LLEDWEY"/>
    <dbReference type="OrthoDB" id="5282002at2759"/>
    <dbReference type="PhylomeDB" id="B8MPB7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4470" evidence="1">
        <location>
            <begin position="59"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="346" mass="39133" checksum="145B07A34013323D" modified="2009-03-03" version="1">MCLQYCGPICQKSHWSHHKIECKSALGKETWQPAWVLEKRTPAFIGTGIGETFGATKYLWGNVPAFDVLELGSNEGEEYEGDLRILLQSGGSFETEISLPIASGDLRNLIKTIARLPSSYNHLLEVTLNDRDFEIVARNLILLLVALVVGNSHEAVDCIIHLWYSTLVRESDIRILQDRIQPLIEEVCEKTKNKSPGTLLGKTWTFAHCSLRVVIEQSSWNRLLQIFNKPSGLTAEQALKIRATNTLAFSRRDYRDRYMSCLSPIERVSFHKFRQDGLLLPFGFPRLDFRAPNPCVSGTSKFSKVILTRNRTFFQTADTWPMKYSANSLDGWSLKEVLNTTSGGNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPE2</accession>
    <name>B8MPE2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Guanine nucleotide-binding protein alpha-2 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_105920</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486619.1">
        <property type="nucleotide sequence ID" value="XM_002486574.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486620.1">
        <property type="nucleotide sequence ID" value="XM_002486575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPE2"/>
    <dbReference type="STRING" id="441959.B8MPE2"/>
    <dbReference type="GeneID" id="8100451"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_105920"/>
    <dbReference type="eggNOG" id="KOG0082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014184_6_0_1"/>
    <dbReference type="InParanoid" id="B8MPE2"/>
    <dbReference type="OMA" id="INYGHPD"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090726">
        <property type="term" value="C:cortical dynamic polarity patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180040">
        <property type="term" value="P:negative regulation of pheromone response MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000009">
        <property type="entry name" value="Guanine nucleotide-binding protein G(O) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000051">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF242">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="46"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="180"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="205"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="274"/>
            <end position="277"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED14381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="358" mass="41185" checksum="299D0982A6B67FFA" modified="2009-03-03" version="1">MGCMSSKVEVEDKEAARVNAGIEKQIRNDKKTYDRTVKILLLGAGESGKSTIIKQMRIIHSGGFPEDERRQNRAVIYSNLVVAFKVLMEIMQTQKIDFEKESNQSLGDILAKTEADVDTDEAFSDLSIKEAMVQLWNDQGVQQAVARGHEFALHDNLHYFFNSIDRLFTPGWLPDNQDMLHSRLRTTGITETLFELGQLNFRMMDVGGQRSERKKWIHCFEGVQCLLFMVALSGYDQSLLEDQNANQMHEAMMLFESLANGEWFKRKPIMLFLNKMDLFKTKLPLSPINKHFPDYSGSPTDFDTAAKYFADRFRSINRMPDREIYIHYTNATDTTLLKATMDSVQDMIIQKNLHTLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPF2</accession>
    <name>B8MPF2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA exonuclease Rex3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_106000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486629.1">
        <property type="nucleotide sequence ID" value="XM_002486584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPF2"/>
    <dbReference type="FunCoup" id="B8MPF2">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MPF2"/>
    <dbReference type="GeneID" id="8100459"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_106000"/>
    <dbReference type="eggNOG" id="KOG2248">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022453_4_0_1"/>
    <dbReference type="InParanoid" id="B8MPF2"/>
    <dbReference type="OMA" id="GQCTYHP"/>
    <dbReference type="OrthoDB" id="3996471at2759"/>
    <dbReference type="PhylomeDB" id="B8MPF2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF112">
        <property type="entry name" value="RNA EXONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="6">
        <location>
            <begin position="386"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED14391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="595" mass="66096" checksum="319BE401B50E7418" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPF9</accession>
    <name>B8MPF9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_106070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPF9"/>
    <dbReference type="GeneID" id="8100466"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_106070"/>
    <dbReference type="HOGENOM" id="CLU_2160106_0_0_1"/>
    <dbReference type="InParanoid" id="B8MPF9"/>
    <dbReference type="OrthoDB" id="5077812at2759"/>
    <dbReference type="PhylomeDB" id="B8MPF9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED14398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="117" mass="13365" checksum="026AE67615A6CACE" modified="2009-03-03" version="1">MLILITHFEDVQNRSLINPLQYASWHPRESRENAHARIGASIGCTKEQIAANFIAFQHTIPSSDIVIFSDRSRLVDRFVGGSYIRLQAHYQFLYSSLLYGHRKEVFNIEVEAALAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPQ2</accession>
    <name>B8MPQ2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_106990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486729.1">
        <property type="nucleotide sequence ID" value="XM_002486684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPQ2"/>
    <dbReference type="GeneID" id="8103599"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_106990"/>
    <dbReference type="eggNOG" id="ENOG502R6QQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032506_0_0_1"/>
    <dbReference type="InParanoid" id="B8MPQ2"/>
    <dbReference type="OMA" id="CEMDITQ"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="PhylomeDB" id="B8MPQ2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="484"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED14491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="576" mass="64604" checksum="9F875C9F5AEEE765" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQA4</accession>
    <name>B8MQA4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_057420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487362.1">
        <property type="nucleotide sequence ID" value="XM_002487317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQA4"/>
    <dbReference type="STRING" id="441959.B8MQA4"/>
    <dbReference type="GeneID" id="8108878"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_057420"/>
    <dbReference type="eggNOG" id="ENOG502SQEH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1053674_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQA4"/>
    <dbReference type="OMA" id="CADSHNT"/>
    <dbReference type="OrthoDB" id="5376287at2759"/>
    <dbReference type="PhylomeDB" id="B8MQA4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="244" mass="28070" checksum="6B342E84EF016566" modified="2009-03-03" version="1">MSLNNSAVSSEIVFPVTELSSTTESCVFRYDQGPVKVKVPRKRGRPVGSKKISNSKLQQGFHMTDNDFYFVHMAGDNVNTISKEARTTIRKRVMANYMHRKRKWDETSHDPLRLVRGLERADPFDAFPIKLEAYMLDLLKYYMTTIWKSFYTIESLTSINPMTDYWIPLAFCDDAFLHLLIGCADSHNTRAMHFEDRPIALWHMNKALSIMKIRIATMRSVTDATIASIATLAFVEVCYLFFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQJ6</accession>
    <name>B8MQJ6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SWI5-dependent HO expression protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_058860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487509.1">
        <property type="nucleotide sequence ID" value="XM_002487464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQJ6"/>
    <dbReference type="STRING" id="441959.B8MQJ6"/>
    <dbReference type="GeneID" id="8106488"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_058860"/>
    <dbReference type="eggNOG" id="ENOG502S77X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050241_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQJ6"/>
    <dbReference type="OMA" id="NMHQHNG"/>
    <dbReference type="OrthoDB" id="3918393at2759"/>
    <dbReference type="PhylomeDB" id="B8MQJ6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="104"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="231"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED13398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="39048" checksum="E8FCB1E25B9C4D4D" modified="2009-03-03" version="1">MKRNALRKKSPADALGIRPWALDNNNSSDAPQLNLPRVETRLEMHQTNGLFDSLTTDRRVVSNPSSSPGEGANGVKSKSSNNDLSSEWTSAVGHASTGKSGRVIHNLQEEIARLTRELSLYRSRAEEAQHINETLKEQIINITERLRNSEQSNETNLASISRKDRKIEDLRTEVQNEKARRLRAEAETAKVNQLMSEEQDGFHRRCAELQEASNYSTSQYEALSKASQREKSDLQRKFKGIKDELASLREQAELKDREQERLDALIDRQNQELETERRRIQEIFTAYDNYKTSRDREFEDLVAKGRRNQANVDAAVASLKETEDKMKWVMHVKKDIPWAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQQ4</accession>
    <name>B8MQQ4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD-repeat protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_052080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486795.1">
        <property type="nucleotide sequence ID" value="XM_002486750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQQ4"/>
    <dbReference type="STRING" id="441959.B8MQQ4"/>
    <dbReference type="GeneID" id="8106798"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_052080"/>
    <dbReference type="eggNOG" id="KOG0272">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_6_16_1"/>
    <dbReference type="InParanoid" id="B8MQQ4"/>
    <dbReference type="OMA" id="LRQNICD"/>
    <dbReference type="OrthoDB" id="4226663at2759"/>
    <dbReference type="PhylomeDB" id="B8MQQ4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF8">
        <property type="entry name" value="POC1 CENTRIOLAR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="54"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="587"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="621"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="663"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="705"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="747"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="789"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED12684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="933" mass="104324" checksum="FEE0254ED027002D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQS4</accession>
    <name>B8MQS4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_052440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486832.1">
        <property type="nucleotide sequence ID" value="XM_002486787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQS4"/>
    <dbReference type="STRING" id="441959.B8MQS4"/>
    <dbReference type="GeneID" id="8098193"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_052440"/>
    <dbReference type="HOGENOM" id="CLU_017238_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQS4"/>
    <dbReference type="OrthoDB" id="5095651at2759"/>
    <dbReference type="PhylomeDB" id="B8MQS4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="284" mass="33484" checksum="9C1A10F4198A9742" modified="2009-03-03" version="1">MEFSEWEVQRRDIDKIFEWMKRTVCHSYLKTCVHVTHSWKEAYNNLKTQVGQGSREIQRRIRDDYNQHMKPFRGTPRDLEAWLIKWEEIMLQGKKKSMFLEAIRPLDEAWVTSFEHSIDPKIDDKSLTYKDLSNGFRRLIPRLRTKRQSRIIKGSFATHLSKSDDSEEENEESLQRGRAVERGRRRSRSQSFEGGQRSGFAPDKRGGPKPTCPACGGMHFIDFCFYIFGYKAPQEFEPRLWLQQRADRWLNSNAPLAKENRDKLLLKGKNDLALEVDPKSDENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQS6</accession>
    <name>B8MQS6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Elongation factor 2 kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_052460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486834.1">
        <property type="nucleotide sequence ID" value="XM_002486789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQS6"/>
    <dbReference type="STRING" id="441959.B8MQS6"/>
    <dbReference type="GeneID" id="8098195"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_052460"/>
    <dbReference type="eggNOG" id="ENOG502S4BB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077993_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQS6"/>
    <dbReference type="OMA" id="NYVLCDL"/>
    <dbReference type="OrthoDB" id="4224470at2759"/>
    <dbReference type="PhylomeDB" id="B8MQS6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17509">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051852">
        <property type="entry name" value="Alpha-type_PK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992:SF11">
        <property type="entry name" value="ALPHA-TYPE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00811">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-type protein kinase" evidence="7">
        <location>
            <begin position="34"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED12723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="282" mass="31803" checksum="B86348317DDC40AA" modified="2009-03-03" version="1">MGRSSYTANQYSKGEGISRCAGCVHGHHADTPSAKESNSGRYNESSQATHENYELRNPFAEGAFRWVAKGRYVSGPRKGQQCVSKWFKTGAVFSSDYFTLDIKAVDKALELVNRFNQLNIINKVIKINVPAVWTFTDDSHEDWAGQKVLCEPFINNYQKFNSNSGWNDDALPWGKVMQALSHFSYHVSGGFYVLCDLQGGIYQHEVVLSDPVILSRRREYGVTDLGPDGISSFFSQHECNNFCRPNWTKPANPVQHFRPVPGTTMIRRTVPTGYSRPHGTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRD5</accession>
    <name>B8MRD5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF866 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_055350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487141.1">
        <property type="nucleotide sequence ID" value="XM_002487096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRD5"/>
    <dbReference type="FunCoup" id="B8MRD5">
        <property type="interactions" value="549"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MRD5"/>
    <dbReference type="GeneID" id="8102228"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_055350"/>
    <dbReference type="eggNOG" id="KOG1296">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114688_0_0_1"/>
    <dbReference type="InParanoid" id="B8MRD5"/>
    <dbReference type="OMA" id="TAHFVWR"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="PhylomeDB" id="B8MRD5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857:SF0">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED13030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="163" mass="18405" checksum="B313149BC3671552" modified="2009-03-03" version="1">MLSLALTAELQGVAGLQPKDTEEEPYYYTFKVLCSSCREEHPNWVSFSRYEKHDIPGSRGEANFVWKCKLCGKTHSASITAGPNAYQIPENAKNKTQKIIELDCRGLEFTDFKADGDWEAKGAETSTSFSGIDLSEGEWYDYDEKAGEEVSVKDIKFEIRNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRI5</accession>
    <name>B8MRI5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_056210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487233.1">
        <property type="nucleotide sequence ID" value="XM_002487188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRI5"/>
    <dbReference type="STRING" id="441959.B8MRI5"/>
    <dbReference type="GeneID" id="8100686"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_056210"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1062364_0_0_1"/>
    <dbReference type="InParanoid" id="B8MRI5"/>
    <dbReference type="OMA" id="WISTIDF"/>
    <dbReference type="OrthoDB" id="4369706at2759"/>
    <dbReference type="PhylomeDB" id="B8MRI5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="159"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED13122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="262" mass="30127" checksum="5B982655AAAF3724" modified="2009-03-03" version="1">MTSYFKIEHKYPENTTSYDQCRVEWGEDYIICKDGDPYTHYRTFTSGNTLIKDRKTRETIRKETDALCFEMEAAGLMADFPCLVVHGIFDYAYSHQNNNGRALLEDIKQGQNRALDQQGSSHSEKMAKLLLDSHHRCHQVFKTSTYEKFKNINPNRVEGTCEWALKSPEYQRWWNTTSNDLLWISADPGCRKSVLAKSLIDEVFAAADLTVFIVYLFFEDNDEQNSIATALCVVLHQLFSLQPQSAATRIAVLGKKLRENSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSB2</accession>
    <name>B8MSB2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD-dependent oxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_000420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED11965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487619.1">
        <property type="nucleotide sequence ID" value="XM_002487574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSB2"/>
    <dbReference type="STRING" id="441959.B8MSB2"/>
    <dbReference type="GeneID" id="8108665"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_000420"/>
    <dbReference type="eggNOG" id="ENOG502SJ3M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1876921_0_0_1"/>
    <dbReference type="InParanoid" id="B8MSB2"/>
    <dbReference type="OMA" id="ETRENMY"/>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="PhylomeDB" id="B8MSB2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="167" mass="19124" checksum="ABD2D3A82DCF39E2" modified="2009-03-03" version="1">MAPCPPEYAKKRLSVIRFPVNIQNYNLQSQRKVYDVFAKEMSETPGFRNSYIMFEGYSVHGVKLVPSESSAFPHRDDNIIIAPVVTYDNKANNPELDAKANAFGEKLRQTIIAARGQKELHTYVNYASGGETRENMYGFGPWRLQKLAALKKKYDLEQKLNYYASVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSB8</accession>
    <name>B8MSB8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_000480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED11971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487625.1">
        <property type="nucleotide sequence ID" value="XM_002487580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSB8"/>
    <dbReference type="STRING" id="441959.B8MSB8"/>
    <dbReference type="GeneID" id="8108671"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_000480"/>
    <dbReference type="eggNOG" id="ENOG502RNTC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051027_0_0_1"/>
    <dbReference type="InParanoid" id="B8MSB8"/>
    <dbReference type="OMA" id="HISANTQ"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="PhylomeDB" id="B8MSB8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="50714" checksum="7D288AFAC818E768" modified="2009-03-03" version="1">MANSRFHVDNFRPYGRHNRKAPSLHHQKTASRYPTPTSITEFPLSPTSACPPSPNAQTSFTRTRSHTRAQALVHPLPVRPPVEVCAHPRLPQPPSRLSHTRYVQAPEEHSSSSAGSHVMTVPDPTTMTLEPQEQSPSPPQSPPDSNLNDTDPSTSWLSVVDDYPITEITPHCVTDYGPISYPTRSETILPIDPAILADETPCALTFGRQDSGVSGFISPDEFSQESDSVRDHFASTPNPQPEQQSTSPGAAPLYDPFDQQTHLSHAHTAELETGTASTLQPTCGDGSQDLSSNKRRTVPEYNSGQPSKRVCARTTPNENVNTPLIPTLCSYFLTAPVDDRLEFLSWLFDGALSQCMSGFPTTPTSSLNKARIKGTGRRGRQTRQLVPTASESVPSSAKGRKGMSWEPEEIDLLVQLRRVEKLPWSDVVKRLTERFPGRTAGSIQTPHMTPPGKRRTSPYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTB4</accession>
    <name>B8MTB4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_004150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488018.1">
        <property type="nucleotide sequence ID" value="XM_002487973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTB4"/>
    <dbReference type="STRING" id="441959.B8MTB4"/>
    <dbReference type="GeneID" id="8100126"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_004150"/>
    <dbReference type="eggNOG" id="ENOG502SBHE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136313_0_0_1"/>
    <dbReference type="InParanoid" id="B8MTB4"/>
    <dbReference type="OMA" id="VEVRWTN"/>
    <dbReference type="OrthoDB" id="5555533at2759"/>
    <dbReference type="PhylomeDB" id="B8MTB4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037652">
        <property type="entry name" value="Mim2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28230">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28230:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19117">
        <property type="entry name" value="Mim2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="129" mass="14227" checksum="D171077F095A31B1" modified="2009-03-03" version="1">MSASILSPGDDSTSPSASAYMIPSRFNISYHSTSSDDDEIASLPSETSSESDLLSDYEDSDAEEQWRESLQQLELLLTMVLVPVIGKYAGRRCAYWGWTKFMEWKYPVEAVITNKAAFRTAGIIGAATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTD1</accession>
    <name>B8MTD1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_004290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488034.1">
        <property type="nucleotide sequence ID" value="XM_002487989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTD1"/>
    <dbReference type="STRING" id="441959.B8MTD1"/>
    <dbReference type="GeneID" id="8100140"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_004290"/>
    <dbReference type="eggNOG" id="ENOG502RNWX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1284040_0_0_1"/>
    <dbReference type="InParanoid" id="B8MTD1"/>
    <dbReference type="OrthoDB" id="4185910at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="215" mass="23015" checksum="6EFE523E36944420" modified="2009-03-03" version="1">MSTFTPNAVQSNTRDPRPLLRPLFHVLRPNNLCVPLIPADELPSWLEVVSTYTIDVNHSFLASYTPHPRLGEYDIICRYCETATQHIHDWNPWSANGLEEQSRIALRTHVSAGAGGYAAANGVMACTVHEEVVTCVFDADAAGVAVVADASIASTDTTATIPTAALFTAVWQTVSTLLTPLSAAKSTAGCATGSRKIRATSTDEQARRSGFRATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8LSU0</accession>
    <name>B8LSU0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SsDNA binding protein Ssb3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_064060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340323.1">
        <property type="nucleotide sequence ID" value="XM_002340282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LSU0"/>
    <dbReference type="STRING" id="441959.B8LSU0"/>
    <dbReference type="GeneID" id="8099951"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_064060"/>
    <dbReference type="eggNOG" id="ENOG502SBIR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141922_2_0_1"/>
    <dbReference type="InParanoid" id="B8LSU0"/>
    <dbReference type="OMA" id="HRYKEIF"/>
    <dbReference type="OrthoDB" id="188186at2759"/>
    <dbReference type="PhylomeDB" id="B8LSU0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04479">
        <property type="entry name" value="RPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000271">
        <property type="entry name" value="Similar to ssDNA binding protein Ssb3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013970">
        <property type="entry name" value="Rfa2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114:SF1">
        <property type="entry name" value="REPLICATION PROTEIN A 14 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114">
        <property type="entry name" value="REPLICATION PROTEIN A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08661">
        <property type="entry name" value="Rep_fac-A_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED22936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="122" mass="13396" checksum="E4AD0A8DE6171170" modified="2009-03-03" version="1">MSLQTPRILPSHLQAFHPSSGGNQRINTVRILGTVTALRGETAVITCGNHGDVTLLLKPDSHLQMGKLVEIVGKVAELSGGQGLGINVLATIDWDSPLNFDYKIYEHVVDVTHRYKEIFYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8LT08</accession>
    <name>B8LT08_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="9">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_064700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Esterase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate esterase 1 (CE1) family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340391.1">
        <property type="nucleotide sequence ID" value="XM_002340350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LT08"/>
    <dbReference type="STRING" id="441959.B8LT08"/>
    <dbReference type="GeneID" id="8099958"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_064700"/>
    <dbReference type="eggNOG" id="ENOG502QTDU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027551_1_1_1"/>
    <dbReference type="InParanoid" id="B8LT08"/>
    <dbReference type="OMA" id="WGPNLQG"/>
    <dbReference type="OrthoDB" id="2425929at2759"/>
    <dbReference type="PhylomeDB" id="B8LT08"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050955">
        <property type="entry name" value="Plant_Biomass_Hydrol_Est"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01840">
        <property type="entry name" value="esterase_phb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037:SF3">
        <property type="entry name" value="FERULOYL ESTERASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 9" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029033851" description="Carboxylic ester hydrolase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED23004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="297" mass="32143" checksum="E05D19757C540BAD" modified="2009-03-03" version="1">MRLFFFLFALLSSTLTSAAITRGQFSQVTDSWGSNPTNTGFYIYVPRNLASKPGIIVAIHYCTGTAQAYYQGTPYAQLAEQYGFIVIYPSSPYSGTCWDVSSHAALTHNGGGDSNSIANMVTWTTSQYNADTSKIFVTGSSSGAMMTNVMAATYPELFKAAIVYSGVSAGCFYSAAGQVDAWNSSCAQGQVEASPQAWASIAENMYPGYSGARPKMQIYHGSIDTTLYPENYNETCKQWAGVFGYNYGAPQQVEQNNPQSQYTTTIWGPNLHGIYATGVGHTVPVNGARDMQWFGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTK3</accession>
    <name>B8LTK3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, FAD-binding, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_065370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340468.1">
        <property type="nucleotide sequence ID" value="XM_002340427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTK3"/>
    <dbReference type="STRING" id="441959.B8LTK3"/>
    <dbReference type="GeneID" id="8102008"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_065370"/>
    <dbReference type="eggNOG" id="ENOG502RRJ9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017006_2_0_1"/>
    <dbReference type="InParanoid" id="B8LTK3"/>
    <dbReference type="OMA" id="LICCAVP"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="PhylomeDB" id="B8LTK3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06197">
        <property type="entry name" value="FNR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42815">
        <property type="entry name" value="FAD-BINDING, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42815:SF2">
        <property type="entry name" value="FAD-BINDING, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="357"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="618" mass="68280" checksum="A146E9D4540D0CE8" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8LU38</accession>
    <name>B8LU38_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Patatin-like serine hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_060080</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002339897.1">
        <property type="nucleotide sequence ID" value="XM_002339856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LU38"/>
    <dbReference type="STRING" id="441959.B8LU38"/>
    <dbReference type="GeneID" id="8110184"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_060080"/>
    <dbReference type="eggNOG" id="KOG4231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003059_1_1_1"/>
    <dbReference type="InParanoid" id="B8LU38"/>
    <dbReference type="OMA" id="AACCTSA"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="PhylomeDB" id="B8LU38"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07199">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PNPLA" evidence="8">
        <location>
            <begin position="451"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="7">
        <location>
            <begin position="455"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="7">
        <location>
            <begin position="660"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="490"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED22510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="960" mass="106690" checksum="C804EC5767123AF4" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUR5</accession>
    <name>B8LUR5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_073120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341309.1">
        <property type="nucleotide sequence ID" value="XM_002341268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUR5"/>
    <dbReference type="GeneID" id="8110242"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_073120"/>
    <dbReference type="HOGENOM" id="CLU_723960_0_0_1"/>
    <dbReference type="InParanoid" id="B8LUR5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="382" mass="40378" checksum="64DC690FD147EDDE" modified="2009-03-03" version="1">MADIAETVSQPQDSDKPSESKSSESIAQNIASAALQGGEILAAQQQLVYIPQQQQQVQQQSTQATQTMTIMNNQFVPVSTSPVQVPTSAASPVPVVLPQVQISVHSQPTAVSAPGSIVQKQASVLKEEKKNDAVNKLEKPELSSAQIAAVKPHDPKKPLTTSTQLQTNANTNPNTATMQSRDRGCGLCTAIKKLFQGMTEAENNDNKKDDNQTNTANNGTQDNNTGGQSLGNNTMKMVMQAVMPAPGPAAQNTTSYSSPLTANDNNTTTNASNDQGVNAIATNMTIPNTVQVSSGDTSASPNLFYMIPSSGQPQTEYLMTVQQPLTVVGSPQVAVVPAVDSEVTTNQAIMDGTNMDSGGFNEEEEGYLVDDEDDDGTNDYVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8LV07</accession>
    <name>B8LV07_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF659 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_061190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340015.1">
        <property type="nucleotide sequence ID" value="XM_002339974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LV07"/>
    <dbReference type="GeneID" id="8106171"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_061190"/>
    <dbReference type="HOGENOM" id="CLU_1687894_0_0_1"/>
    <dbReference type="InParanoid" id="B8LV07"/>
    <dbReference type="OrthoDB" id="2976890at2759"/>
    <dbReference type="PhylomeDB" id="B8LV07"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED22628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="17352" checksum="3A7FB85A227FA204" modified="2009-03-03" version="1">MYEELKASAETVSFFLDVWKTSNKKYILVICHLSTEDFEDRQLVIHFGHCVYGNPQLSISTGILVIPLHLPSALGMSPVGLYVTISSGISQGIKLFKPTVISRVRSHMGHTGEDMAKEIQDELQNFDLGQKLVAICNDNASNNPTLCHSLHKLLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8LV78</accession>
    <name>B8LV78_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retrovirus polyprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_065810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340515.1">
        <property type="nucleotide sequence ID" value="XM_002340474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LV78"/>
    <dbReference type="STRING" id="441959.B8LV78"/>
    <dbReference type="GeneID" id="8106190"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_065810"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_42_2_1"/>
    <dbReference type="InParanoid" id="B8LV78"/>
    <dbReference type="OMA" id="MAWEREG"/>
    <dbReference type="OrthoDB" id="4502494at2759"/>
    <dbReference type="PhylomeDB" id="B8LV78"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000003">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="263" mass="30641" checksum="2062BB2622075477" modified="2009-03-03" version="1">MLGGNGFHRLVQQKKSNIFFTSLHEIDKIIDGKSKTEKELELEEIREKLPFLYLKDFANVFSKRDYHPLYKMSLEELEAVREYILDNLSKGFIKPSNAPFASPIIMAEKPGGSLRFCVNYHKLNQLTKKDRYPLPLIDEVFERLNRACIFTKLDIRYGTYKYKVMPFGLINGPATFQRLVNDLFMDCLDQFLIAFIDDLLIYSENELEHEIHVKRVLERLRNAGLQAALHKCEFHVTHTKFLGFILTSEGIEVDQEKVCAITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVR9</accession>
    <name>B8LVR9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-ketoacyl-acyl carrier protein reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_075710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341586.1">
        <property type="nucleotide sequence ID" value="XM_002341545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVR9"/>
    <dbReference type="STRING" id="441959.B8LVR9"/>
    <dbReference type="GeneID" id="8099930"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_075710"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="InParanoid" id="B8LVR9"/>
    <dbReference type="OMA" id="KMTRADW"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="PhylomeDB" id="B8LVR9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000374">
        <property type="entry name" value="3-oxoacyl-(Acyl-carrier-protein) reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="9"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED24199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="256" mass="27469" checksum="CF91334A6B6CC404" modified="2009-03-03" version="1">MDDLTLDGKVAIITGSSRGIGEGLAVEFARRGAKVVITYTSESSSAKADKVLSCIVGYQYGRSAIKVQADLRTLEGPSQIVAATLKAFPDDGIDILVNNAGCEVQKRLSEVTAEDLQYVYDLNVRGTMLMTQAVLPHLRRPGRIINIASVAARAGLSGYSLYASSKAAMEGFTRCWAAELGADGHTVNCVNPGPVDTDMIYQINPDIVEAQKKSTPVEQRLATVDDIAQICAFLAEERSRWVTGQTISASGGWTMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVV2</accession>
    <name>B8LVV2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED19</name>
        <name evidence="11" type="ORF">TSTA_076830</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 19 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341705.1">
        <property type="nucleotide sequence ID" value="XM_002341664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVV2"/>
    <dbReference type="STRING" id="441959.B8LVV2"/>
    <dbReference type="GeneID" id="8106033"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_076830"/>
    <dbReference type="eggNOG" id="ENOG502QXG3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036911_1_0_1"/>
    <dbReference type="InParanoid" id="B8LVV2"/>
    <dbReference type="OMA" id="TSAFHLC"/>
    <dbReference type="OrthoDB" id="2160599at2759"/>
    <dbReference type="PhylomeDB" id="B8LVV2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013942">
        <property type="entry name" value="Mediator_Med19_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08633">
        <property type="entry name" value="Rox3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="353"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED24318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="453" mass="49390" checksum="EE9CCF73CE7E9752" modified="2009-03-03" version="1">MSDSFSLAGNVSPTSFSASNLKANHSPDISNNSYPQTPTSPPLMSVGAQNYASNFAHTHTSPSHTTTSNGQPLSSPPSSTPMSTQNSQQPTVSATASFPTPASSVSGHLRNTTPADESEAADKSWGQGIQNSHATGSTEFGSVDRTGHRRTDHDRHKLPEGSNMKGRPPVADVDMMDIDSKEDLNSSIRDSSLDALQQDIGTAFHLCKSVPTITGPDPSFDLISLYGLGPIGRSVMRADPTTGEKINRLRKSYEGKLKGLGLSGRNKAVKNENGQSGGLRHLMMWPEEEWQIQKVHGKEIKFAEAESSLQKLQMRAMKLEPGPIPNSEYWEDILGHEKPAKHTNIENGKRAVSTPNALRPTNQANGVPATTAAPERARPTRGKKRHYDDNSFVGYGEGFVDDDDEAALYSNSEDRSGKKKRKKVFKSSRTHYQNVSYARTDGQLWGRHVWNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8LW34</accession>
    <name>B8LW34_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_074400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341449.1">
        <property type="nucleotide sequence ID" value="XM_002341408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LW34"/>
    <dbReference type="STRING" id="441959.B8LW34"/>
    <dbReference type="GeneID" id="8101226"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_074400"/>
    <dbReference type="eggNOG" id="ENOG502S1DF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013056_2_0_1"/>
    <dbReference type="InParanoid" id="B8LW34"/>
    <dbReference type="OMA" id="GDWTGEK"/>
    <dbReference type="OrthoDB" id="5407645at2759"/>
    <dbReference type="PhylomeDB" id="B8LW34"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED24062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="376" mass="42317" checksum="9CFF71B5197353DA" modified="2009-03-03" version="1">MSYYDSRDSRGYRVKRDRYSRPDGAYVEETYVDSRGGYPYDYDTRLIRRRGDSEESVVEEISRDFPPGEYYYGYPGPRRAATVREGARRARSVGRDPYYDGEYYRRDDYRPRRSRRSDGQRDRYERSTYSSSRSPSPRPRRRKSLGEEALGAIGGALGLKAARDRSRDRDHDSDRGRSRKYRSYSDSRSRSRGHRAKSEARIAQAMKAALAAGAAEAFRVRNTPGPWTGEKGRRVLTAAVSAGGVDGLIDRDPNKHGGRHVLESILAGMATNRLVNGARSNSRSRKDRGRSQSRGGIGDMAAAGILAAAGKQAYDRFSKSRGRDRSDSRDSRDSNRDSKKRSSSVSRAINKGLAALGLDDKNHNDRGRDRSRRSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWC5</accession>
    <name>B8LWC5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_076070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341623.1">
        <property type="nucleotide sequence ID" value="XM_002341582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWC5"/>
    <dbReference type="STRING" id="441959.B8LWC5"/>
    <dbReference type="GeneID" id="8104257"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_076070"/>
    <dbReference type="eggNOG" id="ENOG502S7E3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103432_0_0_1"/>
    <dbReference type="InParanoid" id="B8LWC5"/>
    <dbReference type="OMA" id="AFYGYAM"/>
    <dbReference type="OrthoDB" id="2550114at2759"/>
    <dbReference type="PhylomeDB" id="B8LWC5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39605">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39605:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED24236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="182" mass="19498" checksum="A02744648315DB74" modified="2009-03-03" version="1">MDVFNLYTYGSSAWLALQGLALVATPKLIITLLIDDTRPPSDVEAYLSRAFGLALLAVATLTILLTGSVPLGSSVGGVDTTTTSTENENARSPYAVPTVLVTTLFQATLAFYNYTWYLARSQTALGLGMVGSGVVAAVGVWCMLFGTSKGRISRRTGADKRTSGFPFKNAEADKRHPERKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWQ0</accession>
    <name>B8LWQ0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromatin modification-related protein EAF3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Chromatin modification-related protein eaf3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_078100</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MRG family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341834.1">
        <property type="nucleotide sequence ID" value="XM_002341793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWQ0"/>
    <dbReference type="FunCoup" id="B8LWQ0">
        <property type="interactions" value="672"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LWQ0"/>
    <dbReference type="GeneID" id="8108493"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_078100"/>
    <dbReference type="eggNOG" id="KOG3001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039566_1_1_1"/>
    <dbReference type="InParanoid" id="B8LWQ0"/>
    <dbReference type="OMA" id="GLQTYFD"/>
    <dbReference type="OrthoDB" id="124855at2759"/>
    <dbReference type="PhylomeDB" id="B8LWQ0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000077">
        <property type="entry name" value="Chromatin modification-related protein eaf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.30:FF:000004">
        <property type="entry name" value="Putative Chromatin modification-related protein eaf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038133">
        <property type="entry name" value="HAT_Nua4_EAF3/MRG15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="14">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="85"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00057322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED24447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="330" mass="38511" checksum="D404B8A0A907ED59" modified="2009-03-03" version="1">MAPTSSNYNRDEKVLCFHHEVLYEAKIMDMRHVDPDDRKSPYEYLVHYKGWKNTWDDWVPQERLRKFTEENRELAAQIRREVTAQMWGKSNVTTSKTSKRRGGSDSGRGSEERQSSVPAKGTKRGRDNEIEKEDQFHLRPSIRIMLPDTLKALLVDDWENITKNQQVVALPAHHSVNEILQSYSEEEKPKRTTTAELDILEEVIMGIKEYFDKSLDKVLLYKFEREQYRLLRQKWESGAENYVDKGPLDIYGAHHLARLFAVLPELIAQTNMDQQSINRLREELSKFTIWLSRNSEKFFSNKYISASTEYLEKATGVPIPNPGTATSRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXH8</accession>
    <name>B8LXH8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polyubiquitin UbiD/Ubi4, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_078380</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341866.1">
        <property type="nucleotide sequence ID" value="XM_002341825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXH8"/>
    <dbReference type="SMR" id="B8LXH8"/>
    <dbReference type="FunCoup" id="B8LXH8">
        <property type="interactions" value="678"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LXH8"/>
    <dbReference type="GeneID" id="8104716"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_078380"/>
    <dbReference type="eggNOG" id="KOG0001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010412_7_0_1"/>
    <dbReference type="InParanoid" id="B8LXH8"/>
    <dbReference type="OMA" id="VHENTRR"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="PhylomeDB" id="B8LXH8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000004">
        <property type="entry name" value="Polyubiquitin Ubiquitin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="153"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="229"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED24479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="305" mass="34287" checksum="E6BBBF708CA6276A" modified="2009-03-03" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXP5</accession>
    <name>B8LXP5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lysine-specific histone demethylase Aof2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_079030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341933.1">
        <property type="nucleotide sequence ID" value="XM_002341892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXP5"/>
    <dbReference type="STRING" id="441959.B8LXP5"/>
    <dbReference type="GeneID" id="8102517"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_079030"/>
    <dbReference type="eggNOG" id="KOG0029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004498_1_2_1"/>
    <dbReference type="InParanoid" id="B8LXP5"/>
    <dbReference type="OMA" id="WCAENPF"/>
    <dbReference type="OrthoDB" id="9982100at2759"/>
    <dbReference type="PhylomeDB" id="B8LXP5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000064">
        <property type="entry name" value="Lysine-specific histone demethylase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000249">
        <property type="entry name" value="Lysine-specific histone demethylase Aof2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF386">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SWIRM" evidence="4">
        <location>
            <begin position="182"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="26"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="83"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="897"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED24546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1054" mass="117791" checksum="D18B76E6A2279C9C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXQ6</accession>
    <name>B8LXQ6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6603 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_079130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341944.1">
        <property type="nucleotide sequence ID" value="XM_002341903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXQ6"/>
    <dbReference type="STRING" id="441959.B8LXQ6"/>
    <dbReference type="GeneID" id="8105962"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_079130"/>
    <dbReference type="HOGENOM" id="CLU_1361221_0_0_1"/>
    <dbReference type="InParanoid" id="B8LXQ6"/>
    <dbReference type="OrthoDB" id="5352492at2759"/>
    <dbReference type="PhylomeDB" id="B8LXQ6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046538">
        <property type="entry name" value="DUF6603"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20248">
        <property type="entry name" value="DUF6603"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6603" evidence="1">
        <location>
            <begin position="15"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6603" evidence="1">
        <location>
            <begin position="91"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED24557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="201" mass="21682" checksum="883135F3A8A68D49" modified="2009-03-03" version="1">MQNGLQGDPSESVGLNGWISLAEGQFWLAAGLTCTAFQVLNIQAVATLSWGSQDTKLGVFADCIAKYPLSAKNDDELFLLVELGIVTVMPYTRWFFTINFNVHFGASVHLHGPPMAGYVFVDWNIISFTIQFGDSAPQNNPLSWDKEWALLKQIDSPAGGGGGNDNAAHVFAATGGFTTSPADAVSVTEQRCNMDCLTWSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>B8LY93</accession>
    <name>B8LY93_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Fungal specific transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_067700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340725.1">
        <property type="nucleotide sequence ID" value="XM_002340684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LY93"/>
    <dbReference type="STRING" id="441959.B8LY93"/>
    <dbReference type="GeneID" id="8102662"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_067700"/>
    <dbReference type="eggNOG" id="ENOG502QV53">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007003_5_0_1"/>
    <dbReference type="InParanoid" id="B8LY93"/>
    <dbReference type="OMA" id="IEPWWDS"/>
    <dbReference type="OrthoDB" id="2154091at2759"/>
    <dbReference type="PhylomeDB" id="B8LY93"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF77">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="658"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="733"/>
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        </location>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
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        <location>
            <begin position="761"/>
            <end position="777"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED23338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="907" mass="101906" checksum="2F9EC7316F2B7ABA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYF4</accession>
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        </submittedName>
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        <name evidence="2" type="ORF">TSTA_063620</name>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002340229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYF4"/>
    <dbReference type="STRING" id="441959.B8LYF4"/>
    <dbReference type="GeneID" id="8101996"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_063620"/>
    <dbReference type="eggNOG" id="ENOG502RS2E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_446244_0_0_1"/>
    <dbReference type="InParanoid" id="B8LYF4"/>
    <dbReference type="OrthoDB" id="5401486at2759"/>
    <dbReference type="PhylomeDB" id="B8LYF4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="609" mass="67759" checksum="C893EE4E0559A848" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYT0</accession>
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            <fullName evidence="5">Mitochondrial intermediate peptidase</fullName>
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            <fullName evidence="14">Octapeptidyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
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        <name evidence="18" type="ORF">TSTA_068610</name>
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    <organism evidence="18 19">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.</text>
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        </reaction>
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            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M3 family.</text>
    </comment>
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    </dbReference>
    <dbReference type="RefSeq" id="XP_002340824.1">
        <property type="nucleotide sequence ID" value="XM_002340783.1"/>
    </dbReference>
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        <property type="interactions" value="639"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LYT0"/>
    <dbReference type="GeneID" id="8102380"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_068610"/>
    <dbReference type="eggNOG" id="KOG2090">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001805_0_0_1"/>
    <dbReference type="InParanoid" id="B8LYT0"/>
    <dbReference type="OMA" id="ALMFEYM"/>
    <dbReference type="OrthoDB" id="17530at2759"/>
    <dbReference type="PhylomeDB" id="B8LYT0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06457">
        <property type="entry name" value="M3A_MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033851">
        <property type="entry name" value="M3A_MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF79">
        <property type="entry name" value="MITOCHONDRIAL INTERMEDIATE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="17">
        <location>
            <begin position="291"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012441"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EED23437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="795" mass="89355" checksum="A13049DFA4E8B488" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZ01</accession>
    <name>B8LZ01_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_069300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340896.1">
        <property type="nucleotide sequence ID" value="XM_002340855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZ01"/>
    <dbReference type="STRING" id="441959.B8LZ01"/>
    <dbReference type="GeneID" id="8102664"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_069300"/>
    <dbReference type="HOGENOM" id="CLU_000288_34_22_1"/>
    <dbReference type="InParanoid" id="B8LZ01"/>
    <dbReference type="OMA" id="WAREEKV"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="PhylomeDB" id="B8LZ01"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED23509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="28289" checksum="0B8CCD90097E4A88" modified="2009-03-03" version="1">MLDEEHPVLPAADPRDANPYLLGRVSDHNVVIACLPAETTGKVSAATVTDMIHSFPSIRFGLMVGIGGGVPHHTYPEQGAGVEIGEDDDESEDEMEEIPDIRLGDVVVSLHTKSTEAVVQYDFGKSLQEKEFVHTGGKLNAVARLQANHTRGHYKIPELLSKMLADNPSMANFQHPGSEKDRLFKADIIHVEAPKIHCGTIGSADQVMKNAILRDQWALKENILSVWKLLYKLILNHAPTKILALQFNDKRIFFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZD0</accession>
    <name>B8LZD0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phenylacetyl-CoA ligase, putative</fullName>
            <ecNumber evidence="7">1.13.12.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_089190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="1.13.12.7" evidence="7"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478646.1">
        <property type="nucleotide sequence ID" value="XM_002478601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZD0"/>
    <dbReference type="STRING" id="441959.B8LZD0"/>
    <dbReference type="GeneID" id="8104886"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_089190"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="InParanoid" id="B8LZD0"/>
    <dbReference type="OMA" id="IPINPIY"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="PhylomeDB" id="B8LZD0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000003">
        <property type="entry name" value="Long-chain-fatty-acid--CoA ligase FadD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="457"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED21683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="562" mass="62739" checksum="481E0E8AF9875CB7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZG2</accession>
    <name>B8LZG2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit M</fullName>
            <shortName evidence="5">eIF3m</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_089520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit M family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478678.1">
        <property type="nucleotide sequence ID" value="XM_002478633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZG2"/>
    <dbReference type="STRING" id="441959.B8LZG2"/>
    <dbReference type="GeneID" id="8104919"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_089520"/>
    <dbReference type="eggNOG" id="KOG2753">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035254_0_1_1"/>
    <dbReference type="InParanoid" id="B8LZG2"/>
    <dbReference type="OMA" id="FNDEHKG"/>
    <dbReference type="OrthoDB" id="10267031at2759"/>
    <dbReference type="PhylomeDB" id="B8LZG2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03012">
        <property type="entry name" value="eIF3m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027528">
        <property type="entry name" value="eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040750">
        <property type="entry name" value="eIF3m_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF2">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18005">
        <property type="entry name" value="eIF3m_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="207"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="422"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED21715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="466" mass="50791" checksum="5C3076B3DFFCFDEA" modified="2009-03-03" version="1">MPAPTNTLLIEGSFTELCEELAQYLNVLRSNEGGASVNAEIAPLLEPLRQQEQNGEEPNLGQRDEVLKKIVAAAAVLNNAPEKEFIPAYNLLVYLIQQSSDPDIFLSRICFYLSKPVTSSAQFGPSLALTILTTIFNTLAPSDSSRYHVFLAIVAVIRQSGSTTAYEALKEQLVNQLPNWLASWELDEEDAQKLHLAIADAAEAAGDSEFAHAHIVEALQAIDANEASSKENRELAVRALTSALAHPAIFDFTSLSASDAVQALRSSDTSLFELLEIFAADTLDAYDDFISSTPLSSISGGVLADSGDALQTKMRLLTLTSLASSTPSRSLPYAAIASALRVADTEVEKWVIDTIRAGLVEGKLSQLRSEFLVHRATYRVFGEKQWAEVQGRLFVWRRSLEGVLGVIRTERERYARELQQQQAAAQAAEEGGAVGKGGDKKSTGDRRRHQQHQSQPHEVDLLGEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZW1</accession>
    <name>B8LZW1_TALSN</name>
    <protein>
        <submittedName>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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</entry>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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                <person name="Fedorova-Abrams N.D."/>
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        </source>
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            <dbReference type="EMBL" id="EED20952.1"/>
        </source>
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        <source>
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    </evidence>
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</entry>
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    <accession>B8M0V8</accession>
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        <alternativeName>
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    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF31">
        <property type="entry name" value="PROTEIN PXR1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="12">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="165"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="15"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
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        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED21738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="342" mass="38300" checksum="92449CE0462F830C" modified="2009-03-03" version="1">MGLAAPRKRVKISHDPNNTTWAQSTSGFGHKIMTSQGWTPGSYLGARNANHADTFTAASASHIRVTLKDDTLGLGARPRTLGNDDVAAIDAFQGLLGRLNGKSDVQLEQEQRKRDDTRLALYASKKWQAVTFVSGGYLVQEKPDDVLKSKSKKKYHSSNDTTVVDKASFGKSSDDSVDDTPSQSEDAVSSVKAGKSSRTAEAKDTKEKSKKKDKEGKKEKSDKKVKKEKKDKKERKERKERKREKEQKKKDEKDSSKKRRRAEEDLDSESSESSSLDEADNKASQQKATSTQAPRPNWRHAIRGRHIQQKRMAIMDDRSLGEVSIQLICVTIQFLIYMLTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8M101</accession>
    <name>B8M101_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-1,6-glucan boisynthesis protein (Knh1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_090200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478744.1">
        <property type="nucleotide sequence ID" value="XM_002478699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M101"/>
    <dbReference type="FunCoup" id="B8M101">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M101"/>
    <dbReference type="GeneID" id="8108108"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_090200"/>
    <dbReference type="eggNOG" id="ENOG502S28F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063732_0_0_1"/>
    <dbReference type="InParanoid" id="B8M101"/>
    <dbReference type="OMA" id="PEAFAIN"/>
    <dbReference type="OrthoDB" id="2432613at2759"/>
    <dbReference type="PhylomeDB" id="B8M101"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045328">
        <property type="entry name" value="Kre9/Knh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008659">
        <property type="entry name" value="Kre9/Knh1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154:SF1">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05390">
        <property type="entry name" value="Kre9_KNH1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002874674" evidence="2">
        <location>
            <begin position="22"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="28"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1 C-terminal" evidence="3">
        <location>
            <begin position="176"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED21781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="268" mass="29726" checksum="631B7F52412E2B4F" modified="2009-03-03" version="1">MKLTKATSLLALITLPLLAFADVEFIEPRAGSTVKSGDILTAYWKDSGDLPSLLELHEYDLFLCAGGPEIEYSEELALLVPNGLFDKGNSVSFQIRSDLGSEYPDAYFLKMTSRGTNNMTLVNYSERFSVTGMTGTFSELVQYGLLLAANDTAKYHQELKLRKRQVATAIIPAKDVYNVPYPQQTRGLTKYAPMGKRPATTITAKSGPPQFPTSAFEVAHTFLPIPTWQTTLTASRTWTTSGMENPATPAPHPKDDMQIYLRRWADDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8M143</accession>
    <name>B8M143_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_082180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477948.1">
        <property type="nucleotide sequence ID" value="XM_002477903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M143"/>
    <dbReference type="GeneID" id="8107676"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_082180"/>
    <dbReference type="HOGENOM" id="CLU_2607633_0_0_1"/>
    <dbReference type="InParanoid" id="B8M143"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="79" mass="8929" checksum="F898C2CEF94B08BF" modified="2009-03-03" version="1">MSTRKLSRASNTAPELSPELGTPVIHPRYHEGQKVRYKDVTERYGTDTSIGRVKTVLKDVTPPVGREEVRYEVCPDKCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8M177</accession>
    <name>B8M177_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_082520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477982.1">
        <property type="nucleotide sequence ID" value="XM_002477937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M177"/>
    <dbReference type="STRING" id="441959.B8M177"/>
    <dbReference type="GeneID" id="8107710"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_082520"/>
    <dbReference type="eggNOG" id="ENOG502QSJS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016583_1_1_1"/>
    <dbReference type="InParanoid" id="B8M177"/>
    <dbReference type="OMA" id="NYIIHTG"/>
    <dbReference type="OrthoDB" id="3918848at2759"/>
    <dbReference type="PhylomeDB" id="B8M177"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018829">
        <property type="entry name" value="DUF2433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056812">
        <property type="entry name" value="RRM_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF11">
        <property type="entry name" value="DUF2433 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10360">
        <property type="entry name" value="DUF2433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25061">
        <property type="entry name" value="RRM_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2433" evidence="2">
        <location>
            <begin position="283"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding" evidence="3">
        <location>
            <begin position="501"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED21019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="669" mass="71265" checksum="84E87DA702D36063" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8M219</accession>
    <name>B8M219_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_087160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478446.1">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RABCONNECTIN-RELATED"/>
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        <property type="entry name" value="Rav1p_C"/>
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        <property type="entry name" value="Putative isomerase YbhE"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="405"/>
            <end position="436"/>
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        <location>
            <begin position="602"/>
            <end position="1242"/>
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        <location>
            <begin position="1289"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1301"/>
            <end position="1311"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED21483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1327" mass="149798" checksum="1A68765AA23D6D7C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2G8</accession>
    <name>B8M2G8_TALSN</name>
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        <submittedName>
            <fullName evidence="3">Glutamyl-tRNA(Gln) amidotransferase subunit A, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_088680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002478550.1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_088680"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_009600_14_3_1"/>
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    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
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        <property type="entry name" value="AS_sf"/>
    </dbReference>
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        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF34">
        <property type="entry name" value="OS04G0183300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="50"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="161"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED21632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="505" mass="54965" checksum="BCCB58CC4837144F" modified="2009-03-03" version="1">MASQNLLNDWELGTPHPPQKRAMASFDALTISARQLISLLHDGILNSVQLVERYLEQIERHEAYLHALISVAPKESLRAIAAKLDEEHAKGRLRSPLHGIPIIIKVGPVNPKGPDILRSFPTLIPDDRGKDLPSGWSAVGGQTQSPYVRGGVVPGDSKDGHSMPSGSSSGSASAVAAGYAPLSIGTETNGSLVWPASRCALYSIKPTIGLISQQGIVPVSNTCDSAGPMAKSPYDLALLMDVLLEKPPDNSFISSLSQDSWSDISVGVLDYDKWWHDAGFLKPVEEATQEMKFKSEADNGSQSAAFQVAYDSIRKTAKRFAENVPLVSPTDFSLHGIDSLSAVLLSDFPVDFERYLADLEYASLKDFHELKIFKADTNSEVEYPLNHNQARIEDATSMNLSAREYVTHLRNIREIGRTNGIDRILKDYEIDVIIGPADSQMTKIAAAAGYPIASLPLGYLKYNGRAFGMLAIACANNEEKLIQVMGAWDTMFNPVKPPPLLIEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3D2</accession>
    <name>B8M3D2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Diphthine methyl ester synthase</fullName>
            <ecNumber evidence="4">2.1.1.314</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Diphthamide biosynthesis methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_095530</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="EC" id="2.1.1.314"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the diphthine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.314" evidence="4"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479267.1">
        <property type="nucleotide sequence ID" value="XM_002479222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3D2"/>
    <dbReference type="FunCoup" id="B8M3D2">
        <property type="interactions" value="944"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M3D2"/>
    <dbReference type="GeneID" id="8105864"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_095530"/>
    <dbReference type="eggNOG" id="KOG3123">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066040_1_0_1"/>
    <dbReference type="InParanoid" id="B8M3D2"/>
    <dbReference type="OMA" id="HNASIMS"/>
    <dbReference type="OrthoDB" id="2516at2759"/>
    <dbReference type="PhylomeDB" id="B8M3D2"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141133">
        <property type="term" value="F:diphthine methyl ester synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000004">
        <property type="entry name" value="Diphthine synthase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000004">
        <property type="entry name" value="Putative diphthine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01084">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED22304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="284" mass="31539" checksum="8B1DB5EB273330DD" modified="2009-03-03" version="1">MLYLVGLGLADEKDITVRGLEVVKSASRVYLEAYTSILLVEKEKLEAYYGRPVIVADRELVESGSDDILENAKDVDVAFLVVGDPFGATTHTDLVLRARELGIPTRTIPNASILSAIGCTGLQLYNFGQTVSMVFFTETWKPSSYYDRVKENAQLGLHTLVLLDIKVKEQSLENMARGRKIYEPPRYMTVAQCASQMLETEEERQEGVYGPDSLAIGAARVGAPDQKLVAGTLKELAEVDMGRPLHSLVLLGKRAHDLERDYIEQFAVNKETFHAAWKQGYGHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3R6</accession>
    <name>B8M3R6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">KRR1 small subunit processome component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">KRR-R motif-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_038640</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Essential for vegetative growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3. Interacts with MPP10, KRI1 and with ribosomal proteins RPS1A, RPS4A, RPS4B, RPS8A, RPS8B, RPS11A, RPS11B, RPS13, RPS24, RPS25, RPL4A, RPL7B, RPL8, RPL23, RPL25 and RPL28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the KRR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481093.1">
        <property type="nucleotide sequence ID" value="XM_002481048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3R6"/>
    <dbReference type="FunCoup" id="B8M3R6">
        <property type="interactions" value="1075"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M3R6"/>
    <dbReference type="GeneID" id="8107906"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_038640"/>
    <dbReference type="eggNOG" id="KOG2874">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040185_0_2_1"/>
    <dbReference type="InParanoid" id="B8M3R6"/>
    <dbReference type="OMA" id="TPDIDKW"/>
    <dbReference type="OrthoDB" id="441223at2759"/>
    <dbReference type="PhylomeDB" id="B8M3R6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000011">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000014">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006515">
        <property type="entry name" value="KRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 11" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="K Homology" evidence="13">
        <location>
            <begin position="119"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="233"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="274"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED20659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="348" mass="40428" checksum="9425F57D241EF556" modified="2009-03-03" version="1">MPSTYKRDKPWDTDDIDKWKIEEFKPEDNAGGTFAEESSFMTLFPKYREVYLKEAWPMITRTLEKHGIACTLDLVEGSMTVKTTRKTFDPAAILNARDLIKLLSRSVPAQQAIKILEDGVACDIIKIRSLVNNKERFVKRRQRILGPSGSTLKALELLTGTYILVQGNTVSTMGPFKGLKEVRRVIEDCMANIHPIYHIKELMIKRELAKDPTLATESWDRFLPNFKKRTLSKRRVPHKVTDKSQKVYTPFPPPQEKSKIDKELESGEYFLSKQAKERVRKEEIQEKQREKREEKMKERQKDFVPPTEDADKKEKKKKRKRAEDAGDHTEKKKKKKKSKTDESGEISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8M455</accession>
    <name>B8M455_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7708 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_039920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481232.1">
        <property type="nucleotide sequence ID" value="XM_002481187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M455"/>
    <dbReference type="STRING" id="441959.B8M455"/>
    <dbReference type="GeneID" id="8109751"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_039920"/>
    <dbReference type="eggNOG" id="ENOG502SR7Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_479793_0_0_1"/>
    <dbReference type="InParanoid" id="B8M455"/>
    <dbReference type="OMA" id="QCWLSPV"/>
    <dbReference type="OrthoDB" id="5389929at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7708" evidence="2">
        <location>
            <begin position="52"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="209"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED20798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="573" mass="65477" checksum="F6B51EB5BB25007E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4F7</accession>
    <name>B8M4F7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Annexin ANXC3.2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_024740</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479586.1">
        <property type="nucleotide sequence ID" value="XM_002479541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4F7"/>
    <dbReference type="STRING" id="441959.B8M4F7"/>
    <dbReference type="GeneID" id="8106691"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_024740"/>
    <dbReference type="eggNOG" id="KOG0819">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4826">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_390871_0_0_1"/>
    <dbReference type="InParanoid" id="B8M4F7"/>
    <dbReference type="OMA" id="VRGPLMQ"/>
    <dbReference type="OrthoDB" id="5415655at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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</entry>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B8M520</accession>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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            <begin position="527"/>
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        <location>
            <begin position="608"/>
            <end position="626"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="633"/>
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        </location>
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        <location>
            <begin position="661"/>
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        <location>
            <begin position="767"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1190"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1261"/>
            <end position="1292"/>
        </location>
    </feature>
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        <location>
            <begin position="1304"/>
            <end position="1327"/>
        </location>
    </feature>
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        <location>
            <begin position="1333"/>
            <end position="1351"/>
        </location>
    </feature>
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        <location>
            <begin position="1358"/>
            <end position="1376"/>
        </location>
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        <location>
            <begin position="1458"/>
            <end position="1477"/>
        </location>
    </feature>
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        <location>
            <begin position="159"/>
            <end position="411"/>
        </location>
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        <location>
            <begin position="849"/>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED19626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1520" mass="169917" checksum="B7FBCF5F7C476A42" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8M564</accession>
    <name>B8M564_TALSN</name>
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        <submittedName>
            <fullName evidence="4">Mismatched base pair and cruciform DNA recognition protein, putative</fullName>
        </submittedName>
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        <name evidence="4" type="ORF">TSTA_029460</name>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the UPF0337 (CsbD) family.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="CsbD"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00009129"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF05532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED19670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="179" mass="18747" checksum="ADE0927D2ADA144A" modified="2009-03-03" version="1">MASNDSGSSTIKSYVDSAVGTAQNVLSSVTGKPADKQEATAQKAQADQEYEKSHTTARLGPFTADPNTGAAVSDSQDRTSGSWNQTVGAAKESLGNLIGNENLRQTGIQQNADGKAQEARGQLSDLGQGVTDRARGAMGAVGSAVLGDQEGQEKWKDVHDEGKTRQRGVEADLQKAEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5C4</accession>
    <name>B8M5C4_TALSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">TSTA_030010</name>
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    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED19730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002480119.1"/>
    </dbReference>
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    <dbReference type="STRING" id="441959.B8M5C4"/>
    <dbReference type="GeneID" id="8106568"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_030010"/>
    <dbReference type="HOGENOM" id="CLU_847804_0_0_1"/>
    <dbReference type="InParanoid" id="B8M5C4"/>
    <dbReference type="PhylomeDB" id="B8M5C4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="328" mass="37139" checksum="BF66C13970531EF1" modified="2009-03-03" version="1">METYSQISQTISAGRQYREVGFRALSTYALSARTIFAILIETEQILFVPKTSIRIRILRRTLPTQPQSADGSSLLQEISLETITVAIFCTLPYEAAAVRYCLEEDDHYSVSKSQVCHGGQGRPRDPNFKTRSPWGRCRQRSSDNHLGVVQYEFGKYEEDGFDLKGCLNKPPSILLSARLRREAHYRRFYAKLLRNLGSVAQVSKIPCLTGTVPISIRRMIAANMKKYVEGRLSPQARYHPMVHRGLILSGGGIISNTVDRERLRRGYKDSLCYETEAVGIMDEIPCLVIRVVERARVEPYTNRFETKRLGASQSEQPNSGISRLPTLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5Z6</accession>
    <name>B8M5Z6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Catechol dioxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_033660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480557.1">
        <property type="nucleotide sequence ID" value="XM_002480512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5Z6"/>
    <dbReference type="STRING" id="441959.B8M5Z6"/>
    <dbReference type="GeneID" id="8097783"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_033660"/>
    <dbReference type="eggNOG" id="ENOG502QU2V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046727_1_1_1"/>
    <dbReference type="InParanoid" id="B8M5Z6"/>
    <dbReference type="OMA" id="AMGPKTT"/>
    <dbReference type="OrthoDB" id="5238185at2759"/>
    <dbReference type="PhylomeDB" id="B8M5Z6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03461">
        <property type="entry name" value="1_2-HQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039390">
        <property type="entry name" value="1_2-HQD/HQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF7">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catechol dioxygenase N-terminal" evidence="8">
        <location>
            <begin position="23"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="7">
        <location>
            <begin position="105"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED20123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="286" mass="32353" checksum="A134EF59A4F01CFB" modified="2009-03-03" version="1">MATHTYDPTFTDRVINAMGPKTNSRLRQLMAGFIRHIHDFARENELTVDEWMMGVKMINWAGQMSDDKRNEGQLLCDVIGLETLVDEITYKVASEADAPTATAILGPFFRADTMVRQNGDSMVTGVDDGEMVFMHGQVIDYKTKKPIPGTTVEVWQASTNGLYEQQDPNQVEHNLRGKFTTDENGRYWFYCIRPTPYPVPGDGPAGKLLELLDRHPYRPAHIHILATHEGYKPLVTQIFDRQDQYLTNDSVFAVKDSLIVDFVPREGDPNASLELAYDVKLVPKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8M629</accession>
    <name>B8M629_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_023640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479463.1">
        <property type="nucleotide sequence ID" value="XM_002479418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M629"/>
    <dbReference type="STRING" id="441959.B8M629"/>
    <dbReference type="GeneID" id="8109546"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_023640"/>
    <dbReference type="eggNOG" id="ENOG502SJ3M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_0_0_1"/>
    <dbReference type="InParanoid" id="B8M629"/>
    <dbReference type="OMA" id="FENHHSY"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="PhylomeDB" id="B8M629"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF32">
        <property type="entry name" value="FAD-LINKED OXIDOREDUCTASE AFOF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="67"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED19029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="500" mass="54512" checksum="0E0B352F417E0C22" modified="2009-03-03" version="1">MFDILGVVRLTAEMKVFGIGVILALPLLATAQSYNLTALFQPVLSPGAEIYYANDSDWTQNVTQRWTTWDAPTYLGAIKPVTERDVQNIVKVASAHNISFLATGGGHGVSQGFANIQNAIEIDLANFKTVNLDIENNQLTVGGGATYGQLYDPLYNAGKEFPTGNAPCVGVIGATIGAGVGLLQGLHGYTSDALISARIVTASGVLFEASATNNTELFWAIRGAGANFGIITSATYRIYDATNSGQAQNADFLFAESANRTVWNALQTLDETLPAELSVTITSTYNQTSGQASIMVNLVYFGIYDNFQPYVDQFLAISPTQWRNVTVPWNQLIASANFGAPSHGCGTNSSHINFFSIALNQTDPLTFQGFFDDLILFSQQNPSYTGAWVIERYSTQGPLAVPEETRGVYPWREAKMQLLWESDYPDSSLDSTVNAFYTQQRQHFDEFSGFHTFATYVNYAHGDEGPNVWYGDADNLARLSAAKRKWDSNNLFGAAKPVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8M651</accession>
    <name>B8M651_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Endothelin-converting enzyme</fullName>
            <ecNumber evidence="10">3.4.24.71</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_023840</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.71" evidence="10"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479485.1">
        <property type="nucleotide sequence ID" value="XM_002479440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M651"/>
    <dbReference type="STRING" id="441959.B8M651"/>
    <dbReference type="GeneID" id="8109566"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_023840"/>
    <dbReference type="eggNOG" id="KOG3624">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006187_4_3_1"/>
    <dbReference type="InParanoid" id="B8M651"/>
    <dbReference type="OMA" id="FGWAQVW"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="PhylomeDB" id="B8M651"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="9">
        <location>
            <begin position="111"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="8">
        <location>
            <begin position="563"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED19051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="770" mass="86726" checksum="3C387E429D79EBE1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6K7</accession>
    <name>B8M6K7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="17">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">TSTA_027630</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.</text>
    </comment>
    <comment type="function">
        <text evidence="17">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of pre-60S ribosomal complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="17">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="17"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479903.1">
        <property type="nucleotide sequence ID" value="XM_002479858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6K7"/>
    <dbReference type="FunCoup" id="B8M6K7">
        <property type="interactions" value="1146"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M6K7"/>
    <dbReference type="GeneID" id="8109682"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_027630"/>
    <dbReference type="eggNOG" id="KOG0345">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_26_4_1"/>
    <dbReference type="InParanoid" id="B8M6K7"/>
    <dbReference type="OMA" id="AYKEHEC"/>
    <dbReference type="OrthoDB" id="7396459at2759"/>
    <dbReference type="PhylomeDB" id="B8M6K7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17960">
        <property type="entry name" value="DEADc_DDX55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056330">
        <property type="entry name" value="CTT_SPB4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23681">
        <property type="entry name" value="CTT_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 16 22" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 17" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="44"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="282"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="538"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="15">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="581"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EED19469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="634" mass="71086" checksum="5B4022CA2C0F581A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6Q2</accession>
    <name>B8M6Q2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin-like protein (Clg1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_028050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479948.1">
        <property type="nucleotide sequence ID" value="XM_002479903.1"/>
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    <dbReference type="AlphaFoldDB" id="B8M6Q2"/>
    <dbReference type="FunCoup" id="B8M6Q2">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M6Q2"/>
    <dbReference type="GeneID" id="8108321"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_028050"/>
    <dbReference type="eggNOG" id="ENOG502S0QI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030504_1_0_1"/>
    <dbReference type="InParanoid" id="B8M6Q2"/>
    <dbReference type="OMA" id="HWDTWRA"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="PhylomeDB" id="B8M6Q2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF27">
        <property type="entry name" value="PHO85 CYCLIN CLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="474" mass="53062" checksum="9C695B8232E07B96" modified="2009-03-03" version="1">MPSFYNPGLHGLPPTPPHLHGNGKMELDPPFFVTGHTSFPPRYPQTGCEFIEQYSQAASFVKSASVNSHQMMPSVRGGRDYAAALHQQQQQQQHSLAQSQLGGPQSIYGAVSTNVPTLPPIRSSMHLPANSDTAIPPQYRRHDVHIPAETRVKEEKPTGGVAAHLDYEMDQMSDFVAETAQGIVYPGQTIVPPPFRKYVHQILSSTRLPSSTILLGLFYLATRMRMLSAKGIYATGTGQVYRMLTTALLLGSKFLDDNTFQNRSWAEVSNISVSELNTMELDWLFAFEWKIHERIHNKKDGFGVWLARWESYRATMASRNEARQKLSPIDTNITRQLTVPKPLMSPDGPIPPQYQRSNTYENTWLNPTACEYSPPSAPHSGPNTPDYYNGGTWMYTNPPPPYTRTWGSQAEYTYSHPPRSQPPSYHHTPVYTAPVSHSVWTGHGSSCGCTYCLKHHEHYFSCHTFGALQPMVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8M733</accession>
    <name>B8M733_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_034870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480687.1">
        <property type="nucleotide sequence ID" value="XM_002480642.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480689.1">
        <property type="nucleotide sequence ID" value="XM_002480644.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480690.1">
        <property type="nucleotide sequence ID" value="XM_002480645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M733"/>
    <dbReference type="GeneID" id="8104329"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_034870"/>
    <dbReference type="eggNOG" id="ENOG502S5UU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8M733"/>
    <dbReference type="OMA" id="GIWNIKD"/>
    <dbReference type="OrthoDB" id="5363135at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="74"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED20253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="183" mass="20527" checksum="959798387B9B64A5" modified="2009-03-03" version="1">MTEELTRIDSAVAGLSISPKDEKTQTKTVEKEKKAKTHKRVGSTAEGVRNIKDLEKEQIPIEIAIETQKTGWKLNTSPSTIDDREILSKFLVTPPVKKIDLHFPLGLEVTARNLKGVTIKDALDAIHKQFKKKADDELGENPYLAGFEWDPEESWTKLIVHQKKAGAPAATSKKSKKKEKEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7J0</accession>
    <name>B8M7J0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_028320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479977.1">
        <property type="nucleotide sequence ID" value="XM_002479932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7J0"/>
    <dbReference type="GeneID" id="8108348"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_028320"/>
    <dbReference type="eggNOG" id="ENOG502S7GF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038380_0_0_1"/>
    <dbReference type="InParanoid" id="B8M7J0"/>
    <dbReference type="OMA" id="SWEPYSP"/>
    <dbReference type="OrthoDB" id="5398515at2759"/>
    <dbReference type="PhylomeDB" id="B8M7J0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="412" mass="45649" checksum="1259753B2CF3553A" modified="2009-03-03" version="1">MATTPPPASPRELRVPRAPRHGAGYDSFDPYPTRQSARLAGQRTSDRHTTTPPPSSPKKFTRHNDVDTLSPPNTLSPRKKTVRGKALLISEVLDSETSDLSDGAGGLSSRSSIVPGRPQLLPTPVKTPHHQKPGKFGYTARSLFTPTKSAKKPSGYSLDSFQEDPTGNHSSIEIYTDSRDRIPVKNDSIDNPFASKSEIKMSSDRETSQFKRRDLAPELDSKEMVERTDGMLYTFRGKKIFRKFEQRDSDDEEDETEADELGLFANRPDLLDSWTNLHVPRLTRSAIKGRRLFPVSDSKQSESESVDENEEAVTDIEEPVDSIEGTEIVHSEGLESTPGKRSLRSRTTRTHNADKSDPVHAAVSETKKRAKGGSPFDVWARKKPAKVSASKKREADPFIDSPAPVAKKAKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8M916</accession>
    <name>B8M916_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monoxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_111470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481303.1">
        <property type="nucleotide sequence ID" value="XM_002481258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M916"/>
    <dbReference type="STRING" id="441959.B8M916"/>
    <dbReference type="GeneID" id="8109827"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_111470"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_3_1"/>
    <dbReference type="InParanoid" id="B8M916"/>
    <dbReference type="OMA" id="NYRAVIP"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="PhylomeDB" id="B8M916"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="11"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="305"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED17311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="448" mass="49596" checksum="A02AABF8124E0C0B" modified="2009-03-03" version="1">MSSNGPGIQLKITVIGGGMAGLASAIALSDMNPNHQITVLESNASLSEFGAGLQLFANSTRILHKWGLTPALERVAFQSSHVSIRRWEDDAELTFNMNNPYSTWLYGWPQWQIYRPDLQKALFERAKEFPNVSVLFAKSVKSVDAMTGTVYTVDGEVFEADLTVAADGIWSRARRCLPASKDVSPTAYREHNYRAVIPRSRMLSNAITAPFIASPEAKLWVGPGVFVLGYTVASKELYNLVIGVPRPSEGVPVGSWNHPANLETMRGLVSGWCEEVRALASLVQEDCVSWTLGEVPPIPSFVSTSGRVALVGDAAHSLLPHAAQGAGMAFEDAAGLSEFVRHLRSKEDLPKVMDAWSHFRQARVDHLRNISRGNASDMTLPDGELQIARDMKWSTIRDKQRAQWAELGLEKIREKMIREKPTPDPDCKSTFEPGGRIREFCREHLGWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAK4</accession>
    <name>B8MAK4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UDP-galactose transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_112610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481420.1">
        <property type="nucleotide sequence ID" value="XM_002481375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAK4"/>
    <dbReference type="STRING" id="441959.B8MAK4"/>
    <dbReference type="GeneID" id="8105726"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_112610"/>
    <dbReference type="eggNOG" id="KOG2234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024645_2_0_1"/>
    <dbReference type="InParanoid" id="B8MAK4"/>
    <dbReference type="OMA" id="IEEDMMT"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="PhylomeDB" id="B8MAK4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005799">
        <property type="entry name" value="UDP-gal_transpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="392"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED17428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="454" mass="49096" checksum="EA27F583421BD90E" modified="2009-03-03" version="1">MGAAKQTSSKSRSTHIRNFTLLLLTIQYASTVVLIHYSRVMPTVAGKRYVTSTAVFLTEAIKLAISLTMALYEISKRAPPSMPATSLFSNLSNTIFSGDSWKLALPALLYTVANSLQYVALSNLDPATYQVTYQVKLLFAAVFGLLVLQRYIPARNWGLLLFLAAGVVLLHAPGHRSDQLVARDESVQFPRSLEEWKQKKGYSPMKFVKRSASYEGIEEDMLLEHPPLDGRVGLIATLCACLASSLAAVSFEKVIRDSAAKTSLWVRNVQLAVQSVVPAFFIGVIFLDGEVIAKQGFFAGYSWIVWVIIFIQAIGGIGAGYAIVYADQTAKTTATGFSLVVGILSSLSVFDLDLSVNFSIGAIVVLIATFLYGSSAPSPSSLARMRPPPIRIESYDAPENQDGPGASPPNDFSIKLPTTPLLSAGLSTSRPASPSHPRVKSNQNGSGYFLEPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAL3</accession>
    <name>B8MAL3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_112690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481429.1">
        <property type="nucleotide sequence ID" value="XM_002481384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAL3"/>
    <dbReference type="GeneID" id="8105734"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_112690"/>
    <dbReference type="eggNOG" id="ENOG502RZDV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_7_1_1"/>
    <dbReference type="InParanoid" id="B8MAL3"/>
    <dbReference type="OMA" id="GRHFAYI"/>
    <dbReference type="OrthoDB" id="5283415at2759"/>
    <dbReference type="PhylomeDB" id="B8MAL3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="51"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="336"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED17437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="434" mass="47276" checksum="463A5535D1D20213" modified="2009-03-03" version="1">MSTVPSNIEAAQAAGRIPAGLSLNYLAESRDRSAKIAILFVGCLTIVVVVARCYARVFLVKSFGLDDALAAFTVVGLLFTPSDNGTGILILLRSQLLYIAILALCIILIDLGSGRHIEYIQYILSLPQVNRTEVLDFVMHLLYTTALFVCRLSGLAFYQRLASHHSKISVAIKVATGFLIIAYLAQIFLLIFHCVPVTGLWPYVWQPELNEYTCITWGEVYSVNSALSLTCDLIMLVIPFMLIYLLHVSRKRRFQLSLILFPGVIVLAISSVRIYLVVVGQWATDGSWAYNPMLAIETSEIGGTLIALSIPALKPLFGSWFGHVKSSTSGPTPKSSRPEHSGYSHNISRDLKMGQNGNTGSIELNSYHVNIAAGRKHAASTPTISVKDALENDGSSDDLLLDGDVPDRAHSAFSSRIHVSQETTVSAAKASDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8MB55</accession>
    <name>B8MB55_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_125580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482836.1">
        <property type="nucleotide sequence ID" value="XM_002482791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MB55"/>
    <dbReference type="STRING" id="441959.B8MB55"/>
    <dbReference type="GeneID" id="8098070"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_125580"/>
    <dbReference type="eggNOG" id="ENOG502SPKX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042688_2_0_1"/>
    <dbReference type="InParanoid" id="B8MB55"/>
    <dbReference type="OMA" id="VQMINIW"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="PhylomeDB" id="B8MB55"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="35345" checksum="CAED03ED7D4F9C68" modified="2009-03-03" version="1">MATAKITTQHTYDIPAQLTYLEWHDHYETEKPFMVIRYPDDPPEMTGGNVTFKEGEEETIHDIRGHEDDFTLDGNGFLFTHAPTSLAPSDFLDDEKIKTKYLPECEAYLKGLLDADQVIIFHYRVRNTITSDDPYSDTGPARSAHVDLSSQTIRERIRNRYPDRADFLLSGRVRLINLWRPINGPIQNWPLAVCDGNTLPEKNLVLTERIRTRDKAIARFVVHSPAMKWYYQSGMEDGTLLVLKNYDSHAEEGGVARYSAHCSFPLPTAGPDTPPRESVEVRAVVLNYPRDDPSLVEPKPAISNVDSASITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBA5</accession>
    <name>B8MBA5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_126050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482886.1">
        <property type="nucleotide sequence ID" value="XM_002482841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBA5"/>
    <dbReference type="STRING" id="441959.B8MBA5"/>
    <dbReference type="GeneID" id="8098117"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_126050"/>
    <dbReference type="eggNOG" id="ENOG502RPRF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1983055_0_0_1"/>
    <dbReference type="InParanoid" id="B8MBA5"/>
    <dbReference type="OrthoDB" id="4366272at2759"/>
    <dbReference type="PhylomeDB" id="B8MBA5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED18894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="126" mass="14511" checksum="3FA7F5D94B07B5B3" modified="2009-03-03" version="1">MQPANTEIRHKILPHHVFQLQCMLDTFTVSRSWSMSALRGHVLMPPAQGFATSTGCRPISRPRHDEICRAELRRKTFARTAFRSAIDIHNLLGVKGNRFSREPTILNPYQHAQWDPYTFHLGDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCI3</accession>
    <name>B8MCI3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Efflux pump antibiotic resistance protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_125160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482791.1">
        <property type="nucleotide sequence ID" value="XM_002482746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCI3"/>
    <dbReference type="STRING" id="441959.B8MCI3"/>
    <dbReference type="GeneID" id="8100295"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_125160"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_1_1_1"/>
    <dbReference type="InParanoid" id="B8MCI3"/>
    <dbReference type="OMA" id="AMCACPL"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="PhylomeDB" id="B8MCI3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="82"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED18799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="432" mass="47368" checksum="2F7AF8FC4E663F75" modified="2009-03-03" version="1">MAVNEVIPGQGSDKIDEFNEEKKLSQTQRKDEDVERSSVTTEKMDQVEEKVLEPRDPNLVDWDGPDDPENPINWTSKRKAIVTVSIALITFLTPLGSSMFAPGVPNVMRDFKSSNESLAAFVVPVYLLSYCFGPLVIAPLSEMYGRQPLYTICNVLYTVFNVACALAPEMGSLIVFRFISGLAGSCPLTLGAGSLADMIPQEKRGAAMAVWALGPLLGPVIGPVAGGYLTQAKGWWWTFWVLAIAGGAVTISSLISLRESYAYVILDRKAKRLRKETGNPNLRSVLDTGRTPKQLFMFSIVRPTKMLFMSPIVFLLSLYVAVIYGYLYLLFTTIPNVFEVQYGFSQGSVGLPYLGTGVGLLIGLVILGATSDRLLKRLTRSNGGVSKTEYRLPPMFFGSWLVPMALSGMVGLRKRRMLGYCLSCAHLSLVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDS5</accession>
    <name>B8MDS5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">R3H-associated N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_120520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482296.1">
        <property type="nucleotide sequence ID" value="XM_002482251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MDS5"/>
    <dbReference type="GeneID" id="8100036"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_120520"/>
    <dbReference type="eggNOG" id="ENOG502S2TY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064119_0_0_1"/>
    <dbReference type="InParanoid" id="B8MDS5"/>
    <dbReference type="OMA" id="YPRHDPM"/>
    <dbReference type="OrthoDB" id="10256743at2759"/>
    <dbReference type="PhylomeDB" id="B8MDS5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02325">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025952">
        <property type="entry name" value="R3H-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039629">
        <property type="entry name" value="R3HDM4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32019">
        <property type="entry name" value="R3H DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32019:SF2">
        <property type="entry name" value="R3H DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13902">
        <property type="entry name" value="R3H-assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H-associated N-terminal" evidence="2">
        <location>
            <begin position="99"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED18304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="363" mass="41126" checksum="209E6113057475EB" modified="2009-03-03" version="1">MAIHPSLRTGRASTSNLTQQDISAWTEQAAASLQILDISDSVAQIEVINASTPIRGTANALSIPLDGPITATNKPSTPRVKIISKAADDTIGTSAYRRREPIRRDSLRRREALLKGKEGSRRRQRWENDRLLSNPWVQPPAPGDWSVQPTHPRHDPVPYYLAPLWDSHFAHKEQSKSLKQAKSKNREHEDEKTRVSKEIRKSLKHARAARGMLQDLEEDIRRFLEKWNDKQLERELDSVKDSEYEDSDDEIVFVGRNGQMHDAHSRQEKAKRINEGLQEGQKMVFESLAHDPGAVFGRWLVHSIATYYGLYTWSVTSGSPERRQAYVGLNPPVSSTHLADLTHGSSLRIKPGEPLPKPLWVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8ME37</accession>
    <name>B8ME37_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_012230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483348.1">
        <property type="nucleotide sequence ID" value="XM_002483303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ME37"/>
    <dbReference type="STRING" id="441959.B8ME37"/>
    <dbReference type="GeneID" id="8104071"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_012230"/>
    <dbReference type="eggNOG" id="ENOG502RYM3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031559_1_2_1"/>
    <dbReference type="InParanoid" id="B8ME37"/>
    <dbReference type="OMA" id="SWIIDNY"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="PhylomeDB" id="B8ME37"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF3">
        <property type="entry name" value="DUF3431 DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="498" mass="56484" checksum="D7E5E5EAD5E61B4C" modified="2009-03-03" version="1">MHRSNYALPGLGISVCTFTLILAAWHLFFSGDKWRSIPQKVGLGDVIHSRPSSAASYYMPDGSAPPFNISEFVSGIPKKQGSPYSKTLVMAKTKEENTTWTETKLNGSGWDVSIYVVDDPRAPLHPPKNKGHEAMVYLTYIIDNYDNLPDIMAFMHAHQFAWHNEEIFEFDAAEMLRRLSLERVTREGYMNMRCYWSPGCPNWLKPGAIDEDLDKKEERLIAKAWSEIFPNMDIPQVLAQPCCAQFALSRERVRTIPRERFLHYRQWLINTDLRDTMSGRVLEYIWHLVFTGQEVSCPSQNACLCDGFGICFGGENEVNYYYQTLWRIRDANNELKKWQEADGALDEDARIRLSLDELADAQPSENDSQGILLTAEVEEKTAELARLKKEAFKRGEDPVYRAWAAGRQSKPGDGAYGLSCGHSTTHNNVMFHLGTTLGLEEGMFKVCVPILMAPDLSIMKISPVKSRSAQQNSHGPCMYATELQSDATTSNLQWPTWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MF12</accession>
    <name>B8MF12_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS drug efflux transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_009060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483015.1">
        <property type="nucleotide sequence ID" value="XM_002482970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MF12"/>
    <dbReference type="GeneID" id="8100767"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_009060"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="InParanoid" id="B8MF12"/>
    <dbReference type="OMA" id="TSTAWVY"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="PhylomeDB" id="B8MF12"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000429">
        <property type="entry name" value="MFS drug efflux transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED15781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="530" mass="56594" checksum="0A4BCA3172DE5EA6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8MF42</accession>
    <name>B8MF42_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_012500</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483375.1">
        <property type="nucleotide sequence ID" value="XM_002483330.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483376.1">
        <property type="nucleotide sequence ID" value="XM_002483331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MF42"/>
    <dbReference type="FunCoup" id="B8MF42">
        <property type="interactions" value="796"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MF42"/>
    <dbReference type="GeneID" id="8104098"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_012500"/>
    <dbReference type="eggNOG" id="KOG2345">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_109_1_1"/>
    <dbReference type="InParanoid" id="B8MF42"/>
    <dbReference type="OMA" id="AMHQYKV"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13986">
        <property type="entry name" value="STKc_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000550">
        <property type="entry name" value="Serine/threonine kinase 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000374">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000728">
        <property type="entry name" value="Serine/threonine protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052239">
        <property type="entry name" value="Ser/Thr-specific_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998:SF2">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="32"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="168"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="354"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="354"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED16141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="421" mass="46407" checksum="7DB29C9BC5B15399" modified="2009-03-03" version="1">MAQYFFDLLYTFTDCMCCFPSSPQLKINNRSFKLLRLLGEGGFSYVYLVQDKNTSELFALKKIRCPFGQESVSQALKEVEAYSLFTPHPNIIRSFDHCVVNESASKFRGGDDSSSKTVYILLPYYQRGNLQDAINANLVNHTKFPEKELMALMLGVAKALKAMHQYKVKSGPASTRQAKSVRREGEQADEELSRKLGKPKRRNTHGVDDDVEQEPLMDDEVTQSQEGVGEGEFRPYAHRDIKPGNIMIDDDGITPILMDLGSLAPSPIAITSRSLALAVQDTAAEHSTMPYRAPELFDVKTGSIIDTKVDIWSLGCTLYACLVGKSPFEARSEETGGSLSMCVLGGDWRFPDENTSSAKGKAKSNTPAASGSSQASNENGISEPVKEIVRKCLQVEPADRPDIDELIQLISKAIKSLPDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MG41</accession>
    <name>B8MG41_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_010260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483142.1">
        <property type="nucleotide sequence ID" value="XM_002483097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MG41"/>
    <dbReference type="STRING" id="441959.B8MG41"/>
    <dbReference type="GeneID" id="8105665"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_010260"/>
    <dbReference type="eggNOG" id="KOG3764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_51_1_1"/>
    <dbReference type="InParanoid" id="B8MG41"/>
    <dbReference type="OMA" id="MSGINNT"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="PhylomeDB" id="B8MG41"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF35">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="22"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="238"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED15908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="493" mass="52770" checksum="2D59E0287DF29640" modified="2009-03-03" version="1">MAIAAEGRYPIGYRWRSSTHLIIACIATALFTENFLFSFIVPILDYMLEENLNVDPAKAQYVISLVLSVHALVCVIAGPITGHTADKISSRKGALLVSLSCELVGTVIVAAAPSVAILITGRIILAIGGNAAWIIGLATLADTVGTENAAKTLGAISVIYNSGLLVGPMVSGWLLRLVGYWPTWCTAIAVLIIDMAMRLVIIESPKDQKHATTGKPRSATNGINERSLAENVDVEAAGAGEDSTNSLHETTPLLQPPISNPGELQDPSSQKDALQQDNGTSNFYRIVLSHPRALTAMACHMTSSLVVTSLDTTLPLHVIRDFGWNTTQTSSMFFLIQLPQLALGTFTGWLKDKYGTKVPTGVGYLLTGLLLWLLGTPGKDGLSFIGSGQKGQIIYSSILLALGFARSFTIGTGIIEMTSVIREIQTEEPGIFGPNGGYSRAYSLTNLSWNIGLLTGPLLSGTLVQVVGYYYMNFTFGCSNFLSAHVTIMRTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGH4</accession>
    <name>B8MGH4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">mRNA splicing factor (Prp17), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_013920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483528.1">
        <property type="nucleotide sequence ID" value="XM_002483483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGH4"/>
    <dbReference type="FunCoup" id="B8MGH4">
        <property type="interactions" value="840"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MGH4"/>
    <dbReference type="GeneID" id="8099191"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_013920"/>
    <dbReference type="eggNOG" id="KOG0282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022571_2_1_1"/>
    <dbReference type="InParanoid" id="B8MGH4"/>
    <dbReference type="OMA" id="TLWHPHE"/>
    <dbReference type="OrthoDB" id="10257301at2759"/>
    <dbReference type="PhylomeDB" id="B8MGH4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000191">
        <property type="entry name" value="mRNA splicing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="277"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="321"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="407"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="5">
        <location>
            <begin position="487"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="547"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED16294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="575" mass="63746" checksum="AB5810336828F977" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGH7</accession>
    <name>B8MGH7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_018020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483962.1">
        <property type="nucleotide sequence ID" value="XM_002483917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGH7"/>
    <dbReference type="FunCoup" id="B8MGH7">
        <property type="interactions" value="306"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MGH7"/>
    <dbReference type="GeneID" id="8109058"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_018020"/>
    <dbReference type="eggNOG" id="KOG3114">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059606_2_1_1"/>
    <dbReference type="InParanoid" id="B8MGH7"/>
    <dbReference type="OMA" id="VFRRCVA"/>
    <dbReference type="OrthoDB" id="10256463at2759"/>
    <dbReference type="PhylomeDB" id="B8MGH7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="104"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED16728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="305" mass="33547" checksum="813ABA679CA46D24" modified="2009-03-03" version="1">MANQGYDVVVDVDAEGDLGHTDLQEDLEFHPSNFENDPRSAKIQADSQPFLGNDGGPSRGGNGGSGGGISSGGGKRHLWTIQYYSQFFDVDTNEVARRCVAAVYPRSNFLDVLDGNPDLYGPFWIATTVVIILFLTGTISQYLAHEHDEHFEYDFRLLSGAAGLIYGYTGVIPIALWGALRWFGSSSADLIECWALYGYANLLWIAVALASWSPLTALNWALVGVGFAWTVFFLLRNLYPVLSATDAKTSKILLILVVVLHAGLAIAIKVLFFAHGSPVSKKNHHDDDDHKDKDKGHDDRRRVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGQ7</accession>
    <name>B8MGQ7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSTA_018750</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heterohexamer; composed of 3 copies of TIM9 and 3 copies of TIM10, named soluble 70 kDa complex. Associates directly with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
            <topology evidence="1 15">Peripheral membrane protein</topology>
            <orientation evidence="1 15">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484042.1">
        <property type="nucleotide sequence ID" value="XM_002483997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGQ7"/>
    <dbReference type="FunCoup" id="B8MGQ7">
        <property type="interactions" value="651"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MGQ7"/>
    <dbReference type="GeneID" id="8100985"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_018750"/>
    <dbReference type="eggNOG" id="KOG3480">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162151_1_0_1"/>
    <dbReference type="InParanoid" id="B8MGQ7"/>
    <dbReference type="OMA" id="VGENMQK"/>
    <dbReference type="OrthoDB" id="274922at2759"/>
    <dbReference type="PhylomeDB" id="B8MGQ7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042719">
        <property type="term" value="C:mitochondrial intermembrane space chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140318">
        <property type="term" value="F:protein transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038:SF16">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="16">
        <location>
            <begin position="17"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00065568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EED16808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="95" mass="10446" checksum="D93AA8C6F3506854" modified="2009-03-03" version="1">MSFLFGGRPQLSSEQKIAAAETEVEMVSDLFNRLTQSCTKKCIPPEYREGELNKGESVCLDRCVSKFFEVNIKVSEKMQGEAANRQGGGMGGFGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGX6</accession>
    <name>B8MGX6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_014480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002483546.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="8107831"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_014480"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="MIQFGSK"/>
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    <dbReference type="PhylomeDB" id="B8MGX6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
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        <property type="entry name" value="COMT_C"/>
    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF16">
        <property type="entry name" value="O-METHYLTRANSFERASE ELCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Winged helix' DNA-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="SAM_OMT_II"/>
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    </dbReference>
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    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="198"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED16357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="450" mass="49094" checksum="3F0F4B06C95BD8AE" modified="2009-03-03" version="1">MNQSATLQSLSSTIGLKVTEFSNLLKEAGLPEPSFAEKSYADFAHGTATSTESTLRQVRNDLIDAAKDIIRLAMGPIDQVLSLAWSASDTANINIINTFSIAQNVPSGSSISAEDLSAATGLPVDELTRTVRYAITNGIFTEYTPGLFAHSAASAALAHNKHLRDICDFNTDFLASIQIKLAEALKARASGASDAPHAAFNVAYRTKDDLFQHFHKDADLNAKYHAYLAGRVNTPLWSVDRLLTAWNWSALGDATVVDCGGSSGHTCVSLASICPQTKFIVQDMSTDAMELGRESVAFLSSSDSSSPYHDLSSRITFATHDFFTEQKTLADVYIFRHILHDWNDENSVKILKALVPALEKKSAQCNGRHPRVLISEGIVPPPPEKRRGTVTEKMIRIEDSIMLAAHNACERNVQDFIDIFQAADPRFSFIGETSGAKEGAFQSLLEFEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHB7</accession>
    <name>B8MHB7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HD superfamily hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_021530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484330.1">
        <property type="nucleotide sequence ID" value="XM_002484285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHB7"/>
    <dbReference type="STRING" id="441959.B8MHB7"/>
    <dbReference type="GeneID" id="8098419"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_021530"/>
    <dbReference type="eggNOG" id="ENOG502QSR7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036524_0_1_1"/>
    <dbReference type="InParanoid" id="B8MHB7"/>
    <dbReference type="OMA" id="YDNSHDY"/>
    <dbReference type="OrthoDB" id="16547at2759"/>
    <dbReference type="PhylomeDB" id="B8MHB7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.50">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594:SF1">
        <property type="entry name" value="HD_PDEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03035)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED17096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="215" mass="23961" checksum="995FD9FC5FC7B5C1" modified="2009-03-03" version="1">MEPSQDECLITSMTNYMTTCMSGHDPSHNPTHVHRVVSLAHRILASELTLHPDTAPIKYNKTVITLAAILHDIGDHKYLPTDGSAADPKQLVYNALLSHGADEQLASRVQTIVNNVSYTNETRNPDQDADRLDAIGAVGIARTFTYLGSQGLKRAATADSGPWELEDSITHFGEKLERLEGMMKTDTGMQIARERTRRLKLFKEWWVDETAPFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHH6</accession>
    <name>B8MHH6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_010730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483191.1">
        <property type="nucleotide sequence ID" value="XM_002483146.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MHH6"/>
    <dbReference type="GeneID" id="8109846"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_010730"/>
    <dbReference type="eggNOG" id="ENOG502RPXF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003437_0_0_1"/>
    <dbReference type="InParanoid" id="B8MHH6"/>
    <dbReference type="OMA" id="RTELEMW"/>
    <dbReference type="OrthoDB" id="2322499at2759"/>
    <dbReference type="PhylomeDB" id="B8MHH6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057214">
        <property type="entry name" value="DUF7892"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25422">
        <property type="entry name" value="DUF7892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="113"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1099"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1258"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1261"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1290"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1360"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1415"/>
            <end position="1434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED15957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1462" mass="163633" checksum="85B303EF78A3D06B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIC7</accession>
    <name>B8MIC7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_040900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484564.1">
        <property type="nucleotide sequence ID" value="XM_002484519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIC7"/>
    <dbReference type="STRING" id="441959.B8MIC7"/>
    <dbReference type="GeneID" id="8099898"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_040900"/>
    <dbReference type="eggNOG" id="ENOG502S1KN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039076_0_0_1"/>
    <dbReference type="InParanoid" id="B8MIC7"/>
    <dbReference type="OMA" id="LMTIGPE"/>
    <dbReference type="OrthoDB" id="545169at2759"/>
    <dbReference type="PhylomeDB" id="B8MIC7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046366">
        <property type="entry name" value="MPAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124:SF4">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="48690" checksum="B8D69D85298BAF8D" modified="2009-03-03" version="1">MTAGRMLDNTGPFHTLYNNTHLIIALALTIYLALVRRHRYRRMIEIGRPFTDGKRELSSMTTKEAHAIMAQLQELEFPYAFAKARQIALLKAGGIPTMSKLFAATGQNNRRNAGKRAVDTEILLREAQSKSRDSDRYATAVARMNYLHARYRRANKITNNDLLHTLGDGLAEILNVIEREEWRELTDVEKCAIGIFHKNLGEDMGIPFDQLPSKAEGWKDGLHFAMELRKWTISYEEEVARPTATNDQYVRVYIDSAISALPSFLRTIVRQMLSADLDKIMRTSLCIESPNPILIMVLGLVRYFRRLFLRYLALPRPPFLAVKLVHEMPNPGTNLYNFERKSLQPWYIRPTFWSKWGPGALLVKILGGKVPGSRGDRYEPQGYNLMTIGPEPQKGKGMEEMRSDMDIIRTRGVATCPFSQAKSGNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJ17</accession>
    <name>B8MJ17_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_051170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485632.1">
        <property type="nucleotide sequence ID" value="XM_002485587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJ17"/>
    <dbReference type="STRING" id="441959.B8MJ17"/>
    <dbReference type="GeneID" id="8106319"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_051170"/>
    <dbReference type="eggNOG" id="ENOG502QU74">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011527_0_1_1"/>
    <dbReference type="InParanoid" id="B8MJ17"/>
    <dbReference type="OMA" id="LMEMSPT"/>
    <dbReference type="OrthoDB" id="414774at2759"/>
    <dbReference type="PhylomeDB" id="B8MJ17"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588">
        <property type="entry name" value="TPR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588:SF1">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="564" mass="64385" checksum="FADA883498DAED3B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJ41</accession>
    <name>B8MJ41_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_051390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485656.1">
        <property type="nucleotide sequence ID" value="XM_002485611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJ41"/>
    <dbReference type="STRING" id="441959.B8MJ41"/>
    <dbReference type="GeneID" id="8106341"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_051390"/>
    <dbReference type="HOGENOM" id="CLU_2361158_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJ41"/>
    <dbReference type="PhylomeDB" id="B8MJ41"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED15703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="96" mass="11659" checksum="F594566F79CB7395" modified="2009-03-03" version="1">MEFSEWEVQRRDIDKIFEWMKQTVYYSYLKTYVHVTHSWKEAYNNLKMQVGQGSREIQFLEAIRPLDEAWVTSFEHLIDSKIDDKSLTYKDLLNGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJH5</accession>
    <name>B8MJH5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Probable beta-glucosidase L</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Beta-D-glucoside glucohydrolase L</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Cellobiase L</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Gentiobiase L</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TSTA_046290</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 23">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485128.1">
        <property type="nucleotide sequence ID" value="XM_002485083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJH5"/>
    <dbReference type="STRING" id="441959.B8MJH5"/>
    <dbReference type="GeneID" id="8099540"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_046290"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_2_3_1"/>
    <dbReference type="InParanoid" id="B8MJH5"/>
    <dbReference type="OMA" id="MTDWNAQ"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="PhylomeDB" id="B8MJH5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000757">
        <property type="entry name" value="Beta-glucosidase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF28">
        <property type="entry name" value="BETA-GLUCOSIDASE L-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 21" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877781" description="Probable beta-glucosidase L" evidence="19">
        <location>
            <begin position="20"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="20">
        <location>
            <begin position="652"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EED15175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="734" mass="76864" checksum="CA7398477AC020B9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJL2</accession>
    <name>B8MJL2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Presequence protease, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Pitrilysin metalloproteinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSTA_046660</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Degrades mitochondrial transit peptides after their cleavage in the intermembrane space or in the matrix, and presequence peptides; clearance of these peptides is required to keep the presequence processing machinery running. Preferentially cleaves the N-terminal side of paired basic amino acid residues. Also degrades other unstructured peptides. May function as an ATP-dependent peptidase as opposed to a metalloendopeptidase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer and homodimer; homodimerization is induced by binding of the substrate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M16 family. PreP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485165.1">
        <property type="nucleotide sequence ID" value="XM_002485120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJL2"/>
    <dbReference type="FunCoup" id="B8MJL2">
        <property type="interactions" value="673"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MJL2"/>
    <dbReference type="GeneID" id="8104190"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_046660"/>
    <dbReference type="eggNOG" id="KOG2019">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009165_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJL2"/>
    <dbReference type="OMA" id="NYLYYIR"/>
    <dbReference type="OrthoDB" id="10250783at2759"/>
    <dbReference type="PhylomeDB" id="B8MJL2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000013">
        <property type="entry name" value="Mitochondrial presequence protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000009">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000011">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055130">
        <property type="entry name" value="PreP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF13">
        <property type="entry name" value="PRESEQUENCE PROTEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22516">
        <property type="entry name" value="PreP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 17" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16C associated" evidence="16">
        <location>
            <begin position="513"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EED15212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1061" mass="117632" checksum="742284DC0702B529" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJN9</accession>
    <name>B8MJN9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_051750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485691.1">
        <property type="nucleotide sequence ID" value="XM_002485646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJN9"/>
    <dbReference type="STRING" id="441959.B8MJN9"/>
    <dbReference type="GeneID" id="8103396"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_051750"/>
    <dbReference type="HOGENOM" id="CLU_1078400_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJN9"/>
    <dbReference type="OrthoDB" id="4207519at2759"/>
    <dbReference type="PhylomeDB" id="B8MJN9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="27"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED15738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="258" mass="29982" checksum="4D3A2ABDA3ABAE33" modified="2009-03-03" version="1">MGLCATAKVITGSGRYARPKLLQPGNREWVTAIEATNSTGWVLPSYIIFKAKQYTRLGWFEDLPDDWRINISNNGWTTDKIGHTNPRDLWSSLKAGCDQRTTLPLITQYELFHSNKWEPKNTISTYTSYFRNIFLSLENTSYKIHQDIAIHILVDQLPDCYKTEVTYLLANIKDSSSEGDNTSGQALVTRGRRPNRRTSSRNLRNEGNNSNSNRREQSNRNSRNKRLICNWYKREGHYERDCHIRTWQLYRVGSLSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJP1</accession>
    <name>B8MJP1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_051770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485693.1">
        <property type="nucleotide sequence ID" value="XM_002485648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJP1"/>
    <dbReference type="GeneID" id="8103398"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_051770"/>
    <dbReference type="HOGENOM" id="CLU_2414793_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJP1"/>
    <dbReference type="PhylomeDB" id="B8MJP1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="92" mass="11145" checksum="90A986AE800A5BC3" modified="2009-03-03" version="1">MQNPGEAQFFLPSKVEAAKQRIQDIESQKEQDKINAAILRTQEALERERRDRKNQEKRESRIREREAKKQQKELEKEQRRIARETKRQAKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJR7</accession>
    <name>B8MJR7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Purple acid phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_042090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="4"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484687.1">
        <property type="nucleotide sequence ID" value="XM_002484642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJR7"/>
    <dbReference type="STRING" id="441959.B8MJR7"/>
    <dbReference type="GeneID" id="8102986"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_042090"/>
    <dbReference type="eggNOG" id="KOG1378">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013387_2_2_1"/>
    <dbReference type="InParanoid" id="B8MJR7"/>
    <dbReference type="OMA" id="FTEFMHR"/>
    <dbReference type="OrthoDB" id="45007at2759"/>
    <dbReference type="PhylomeDB" id="B8MJR7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PAPs-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="ACID PHOSPHATASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953:SF153">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005124085" description="Purple acid phosphatase" evidence="4">
        <location>
            <begin position="22"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="7">
        <location>
            <begin position="36"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="177"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="6">
        <location>
            <begin position="424"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED14734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="492" mass="53175" checksum="826C3EDF340EBD8A" modified="2009-03-03" version="1">MKSTTSISAAAVLLAAPSVYAGLINFPPIPKDLTTPFQQRLAAYGPSSVSVGWNTYAAQSSGCVQYGTSPDNLNLKSCSTIGSTTYQSSRTYSNVVILSGLAPATTYYYKIVSTNSTVGHFQSPRQPGDKTPFNLDVVVDLGVYGADGFTTSKRDDIPTIQPELNHSTIGRLATTVDDYELVIHPGDFAYADDWFEKPHNLLDGKDAYQAILEQFYDQLAPIAGRKLYMASPGNHEADCTEVPFTSGLCPEGQKNFTDFLHRFGQTMPKAYTSSSTNATAQSLAAKAKSLSNPPFWYSFEYGMVHIAMIDTETDFPNAPDGQDGSAGLDGGPFGATHQQLDFLAADLASVDRSVTPWVIVAGHRPWYTTGDSSSACSSCQDAFEDLLYTYGVDVGVFGHVHNSQRFLPVYKGTADPNGMTDPKAPMYIIAGGTGNIEGLSSVGSVPSYNAFVYADDYSYSTMKFLDEHNLQIDFIRSSTGEILDSSILYKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MK02</accession>
    <name>B8MK02_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino-acid N-acetyltransferase subunit Mak10, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_042910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAK10 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484772.1">
        <property type="nucleotide sequence ID" value="XM_002484727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MK02"/>
    <dbReference type="FunCoup" id="B8MK02">
        <property type="interactions" value="620"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MK02"/>
    <dbReference type="GeneID" id="8104768"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_042910"/>
    <dbReference type="eggNOG" id="KOG2343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011757_0_0_1"/>
    <dbReference type="InParanoid" id="B8MK02"/>
    <dbReference type="OMA" id="QMEWIVQ"/>
    <dbReference type="OrthoDB" id="269405at2759"/>
    <dbReference type="PhylomeDB" id="B8MK02"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057983">
        <property type="entry name" value="NAA35-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007244">
        <property type="entry name" value="Naa35_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057982">
        <property type="entry name" value="TPR_NAA35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373">
        <property type="entry name" value="GLUCOSE REPRESSIBLE PROTEIN MAK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373:SF0">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04112">
        <property type="entry name" value="Mak10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25789">
        <property type="entry name" value="TPR_NAA35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAA35-like N-terminal" evidence="4">
        <location>
            <begin position="38"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="NAA35-like TPR repeats" evidence="5">
        <location>
            <begin position="348"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED14819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="773" mass="87886" checksum="3E1650124549E31C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8MK20</accession>
    <name>SEY1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein sey1</fullName>
            <ecNumber evidence="1">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">sey1</name>
        <name type="ORF">TSTA_043120</name>
    </gene>
    <organism>
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cooperates with the reticulon proteins and tubule-shaping DP1 family proteins to generate and maintain the structure of the tubular endoplasmic reticulum network. Has GTPase activity, which is required for its function in ER organization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">Enriched in the cortical ER. Concentrated in punctae along the ER tubules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="1"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484790.1">
        <property type="nucleotide sequence ID" value="XM_002484745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MK20"/>
    <dbReference type="SMR" id="B8MK20"/>
    <dbReference type="FunCoup" id="B8MK20">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MK20"/>
    <dbReference type="GeneID" id="8104954"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_043120"/>
    <dbReference type="eggNOG" id="KOG2203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011270_0_0_1"/>
    <dbReference type="InParanoid" id="B8MK20"/>
    <dbReference type="OMA" id="PIIKMTE"/>
    <dbReference type="OrthoDB" id="1597724at2759"/>
    <dbReference type="PhylomeDB" id="B8MK20"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048309">
        <property type="term" value="P:endoplasmic reticulum inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016320">
        <property type="term" value="P:endoplasmic reticulum membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01851">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000727">
        <property type="entry name" value="Protein SEY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="RHD3/Sey1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046758">
        <property type="entry name" value="Sey1/RHD3-like_3HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923:SF2">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05879">
        <property type="entry name" value="RHD3_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20428">
        <property type="entry name" value="Sey1_3HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000385002" description="Protein sey1">
        <location>
            <begin position="1"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="763"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="784"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="787"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="808"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="GB1/RHD3-type G" evidence="2">
        <location>
            <begin position="68"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="846"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="463"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="812"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="78"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="880" mass="99244" checksum="F63B5EC8C2D753C6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKW7</accession>
    <name>B8MKW7_TALSN</name>
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        <submittedName>
            <fullName evidence="5">Monocarboxylate transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_044320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484919.1">
        <property type="nucleotide sequence ID" value="XM_002484874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKW7"/>
    <dbReference type="GeneID" id="8104108"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_044320"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="InParanoid" id="B8MKW7"/>
    <dbReference type="OMA" id="LSYRIWA"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="PhylomeDB" id="B8MKW7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF305">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="253"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED14966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="447" mass="46913" checksum="9CFBD23012967932" modified="2009-03-03" version="1">MATTTTTTAIELPNNVARTTAAAANNHSTSHHEDDDVMQASLVADSEVPDGGYGWVLIFACAVICFWFVGTTYCWGVFQAALVEQGVSSASTLAFVGSLTTACVSFMAVVNARVIRKLGPRLSGLLGVSLFGLGEVMAGFVTGDVVGLFMTIGLVMGLGTSLMFMVVSVTPAQYFKTKRGIANGIVYAGGGLGGAIISFVTNGLLQSLGIAWTFRVLGFITLATGLPAAYLIKERVPIRPTSFIEWRLFRDYRFILIFLGGALATFPLFVPPFFLPLYTNSLHMTSSAGAGLVAAFNFSSAIGRLLCGFSSDRIGPLNTVFSSLLLSALSALVLWPVSSSLGPLIVFVIINGMANGGFFATMPTVVSNVFGSARVSVAMGMVVTGWGGGYLLGAPIAGYLLNASGGEKRGIDAFHPAIYYAGSMALGSASLMLMARLGIDRRLTQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLP1</accession>
    <name>B8MLP1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Allantoate permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_101440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486142.1">
        <property type="nucleotide sequence ID" value="XM_002486097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLP1"/>
    <dbReference type="GeneID" id="8101832"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_101440"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1876823_0_0_1"/>
    <dbReference type="InParanoid" id="B8MLP1"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="PhylomeDB" id="B8MLP1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="136" mass="15110" checksum="98BECAAC820B1FFD" modified="2009-03-03" version="1">MASVVPTIAGVIVLLTVPFAPSKRVGLLLAYYIIIAYWGCAGLALSLVTRNVAVGNAIGSQTYQAKDAPRYFPALATVLVCFVLLEVVLFALRTYYIAQNKKRDCMIERGEATEDRNFTHSFEDITDRQNVNFDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLQ4</accession>
    <name>B8MLQ4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_098830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485864.1">
        <property type="nucleotide sequence ID" value="XM_002485819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLQ4"/>
    <dbReference type="STRING" id="441959.B8MLQ4"/>
    <dbReference type="GeneID" id="8099711"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_098830"/>
    <dbReference type="eggNOG" id="ENOG502S3V7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038504_2_0_1"/>
    <dbReference type="InParanoid" id="B8MLQ4"/>
    <dbReference type="OMA" id="VDILDCY"/>
    <dbReference type="OrthoDB" id="5593235at2759"/>
    <dbReference type="PhylomeDB" id="B8MLQ4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="477" mass="53462" checksum="F8AC128D8E9D8AA2" modified="2009-03-03" version="1">MDMSDFKSLRRWGDLPRKISHCSRMTYMVFLAFCGLFLVSLSWVLLRPPTLDSSSLENTTGKVPAAAPTVAHLPTPTPELSSVTIHQSDEGTSHVDHSATPLVKPDGVRIVGVVFYGRRDRSSLLECYLRKNLASFGGWLDEVIWAANTEDADDLSYGEHIAGTADEYTFLPIKNENKDDGYLNIYTHAFTEPDTIYVKMDDDIVFIDQSAIPRVVMTLINNPRALLVSSNVVNNPALGWVHYHMGAVHPYVPEVRPDSDNLATKENGVWRASDLPSWSGAEWEMPELDHFFSLFGVNDRANVPVHRWIPTRDLSLLYKTPVAKSEYNAFGNNLLFWPLAAQAHYSLLQNIEEKRLGRYFMVHGSDEEAVSTWDMRGSRISINFMVIKGKDIIDNLPNLKGDDENQLTVELPASLNRAVLVETTSVVAHFSFGPQKNLAKTDILARYHNYANQNICPNSILEPEILLATDKMPGVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLR9</accession>
    <name>B8MLR9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_098960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485879.1">
        <property type="nucleotide sequence ID" value="XM_002485834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLR9"/>
    <dbReference type="STRING" id="441959.B8MLR9"/>
    <dbReference type="GeneID" id="8103974"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_098960"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_7_0_1"/>
    <dbReference type="InParanoid" id="B8MLR9"/>
    <dbReference type="OMA" id="TWWVNSY"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="PhylomeDB" id="B8MLR9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF5">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED13641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="550" mass="62523" checksum="5E934E7A5840C956" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLX0</accession>
    <name>B8MLX0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_097380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485720.1">
        <property type="nucleotide sequence ID" value="XM_002485675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLX0"/>
    <dbReference type="STRING" id="441959.B8MLX0"/>
    <dbReference type="GeneID" id="8103436"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_097380"/>
    <dbReference type="HOGENOM" id="CLU_002055_1_1_1"/>
    <dbReference type="InParanoid" id="B8MLX0"/>
    <dbReference type="OMA" id="NENIVHW"/>
    <dbReference type="OrthoDB" id="411592at2759"/>
    <dbReference type="PhylomeDB" id="B8MLX0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED13482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="31760" checksum="3E28E6016A24C949" modified="2009-03-03" version="1">MTISTYNLCLLHCIDQSQGFGIIDMQTDDTLILADNTFANYEENEIKQANILCKPREKLTPSNPLKFNGGLITEDAQGITLTQERTYDIKSLNKRLQWQLDNAERGLRFVRLDLDLLCLVIFADLSFANNKDFSSQIGFVIVLVDAVNNENIVHWSLIKCKRVIRSVLASKLYAMVHGFDSAASIKSTTTQLLHLTKPLPLVICTDSKSLYECLVKLGTTQEKRLMIDLMYLRQSYERQEIAEIKWIDGESNPANAMTKSKPCHALQALIDTNKLNINVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MM39</accession>
    <name>B8MM39_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_098070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485789.1">
        <property type="nucleotide sequence ID" value="XM_002485744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MM39"/>
    <dbReference type="STRING" id="441959.B8MM39"/>
    <dbReference type="GeneID" id="8108446"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_098070"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_7_1_1"/>
    <dbReference type="InParanoid" id="B8MM39"/>
    <dbReference type="OMA" id="LSWWFIP"/>
    <dbReference type="OrthoDB" id="10054429at2759"/>
    <dbReference type="PhylomeDB" id="B8MM39"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF13">
        <property type="entry name" value="THIAMINE TRANSPORTER THI9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED13551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="532" mass="58117" checksum="201014D538FCCBD9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MM41</accession>
    <name>B8MM41_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_098090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485791.1">
        <property type="nucleotide sequence ID" value="XM_002485746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MM41"/>
    <dbReference type="STRING" id="441959.B8MM41"/>
    <dbReference type="GeneID" id="8108448"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_098090"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_3_1"/>
    <dbReference type="InParanoid" id="B8MM41"/>
    <dbReference type="OMA" id="VHWFGLL"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="PhylomeDB" id="B8MM41"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000319">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF30">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04702)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED13553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="541" mass="59966" checksum="31C84F83078390EA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMB6</accession>
    <name>B8MMB6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_099230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485908.1">
        <property type="nucleotide sequence ID" value="XM_002485863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMB6"/>
    <dbReference type="STRING" id="441959.B8MMB6"/>
    <dbReference type="GeneID" id="8104001"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_099230"/>
    <dbReference type="eggNOG" id="ENOG502S16F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009388_4_0_1"/>
    <dbReference type="InParanoid" id="B8MMB6"/>
    <dbReference type="OMA" id="MSAWMRR"/>
    <dbReference type="OrthoDB" id="2426273at2759"/>
    <dbReference type="PhylomeDB" id="B8MMB6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596:SF3">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="350"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="791" mass="89515" checksum="4A827BCBC956BA0C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMH6</accession>
    <name>B8MMH6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphatidylinositol:UDP-GlcNAc transferase PIG-C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_099800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGC family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485968.1">
        <property type="nucleotide sequence ID" value="XM_002485923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMH6"/>
    <dbReference type="STRING" id="441959.B8MMH6"/>
    <dbReference type="GeneID" id="8105423"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_099800"/>
    <dbReference type="eggNOG" id="KOG3059">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024002_1_0_1"/>
    <dbReference type="InParanoid" id="B8MMH6"/>
    <dbReference type="OMA" id="ILWDSWV"/>
    <dbReference type="OrthoDB" id="196709at2759"/>
    <dbReference type="PhylomeDB" id="B8MMH6"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009450">
        <property type="entry name" value="Plno_GlcNAc_GPI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06432">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="449"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED13730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="499" mass="54385" checksum="57FAF8290221955F" modified="2009-03-03" version="1">MAPQPQSLPPVPPPVPVETHPNRAGGLKPPLPQRAPPDPSRLAPEHAYAHSQARLWHDGSSHLRPIDGIFATPASVAALRPPPAVPGTEPRKNDIRKFRDGRRKKRKGVWKKLLWVRQSYPDNYTDVETFLDHLQRNPRLRPYDFWPLVADSTVIVQHVCSVVIFVCCFVGIFQSRISPVSVVGSGSIGTLLGWVLWDAWVWKEKNEAIKAAQFADAGDIDDGSSASSTASQTPAAGLQVNGNAANVHGLGLDLPRSDTEVHLRRRSTGISVASLQSVTPGSSFLLGQPSFYSYEGNKPLLSPRNRQRLATIKSALLIYCALLGLSPILKSLTKSTASDSIWALSCWLMIINIFSFDYGSSEGQADATKFPASLSTNAALMASTVLASRLPSTTHVFSLTLFSIEVFGLFPVFRRQLRHVSWTGHVLLTFALVLAAGAGVGIAMRGGWFAAIVGAILSTILTALAMGSCSWWLISLQKYKNVVIGPWDPARPIIRRNWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMT3</accession>
    <name>B8MMT3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA polymerase</fullName>
            <ecNumber evidence="20">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">TSTA_100810</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18 20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="19">Forms DNA polymerase zeta with REV7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="20"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486077.1">
        <property type="nucleotide sequence ID" value="XM_002486032.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B8MMT3">
        <property type="interactions" value="676"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MMT3"/>
    <dbReference type="GeneID" id="8097965"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_100810"/>
    <dbReference type="eggNOG" id="KOG0968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000203_3_1_1"/>
    <dbReference type="InParanoid" id="B8MMT3"/>
    <dbReference type="OMA" id="GRNKMGF"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="PhylomeDB" id="B8MMT3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05778">
        <property type="entry name" value="DNA_polB_zeta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05534">
        <property type="entry name" value="POLBc_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000007">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.342.10:FF:000018">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000002">
        <property type="entry name" value="DNA polymerase zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000024">
        <property type="entry name" value="DNA polymerase zeta catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056435">
        <property type="entry name" value="DPOD/Z_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030559">
        <property type="entry name" value="PolZ_Rev3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056447">
        <property type="entry name" value="REV3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812:SF1">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24055">
        <property type="entry name" value="POL3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24065">
        <property type="entry name" value="REV3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 20" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 20" id="KW-0235">DNA replication</keyword>
    <keyword evidence="15 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12 20" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13 20" id="KW-0408">Iron</keyword>
    <keyword evidence="14 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase zeta catalytic subunit N-terminal" evidence="26">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase delta/zeta catalytic subunit N-terminal" evidence="25">
        <location>
            <begin position="61"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="23">
        <location>
            <begin position="811"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="22">
        <location>
            <begin position="1067"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="24">
        <location>
            <begin position="1567"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="456"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="613"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00066055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF24055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF24065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="EED13839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1672" mass="191713" checksum="50F0B11867517FB3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMU1</accession>
    <name>B8MMU1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytoskeleton assembly control protein Sla2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_100880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLA2 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486085.1">
        <property type="nucleotide sequence ID" value="XM_002486040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMU1"/>
    <dbReference type="FunCoup" id="B8MMU1">
        <property type="interactions" value="258"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MMU1"/>
    <dbReference type="GeneID" id="8098600"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_100880"/>
    <dbReference type="eggNOG" id="KOG0980">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004601_0_0_1"/>
    <dbReference type="InParanoid" id="B8MMU1"/>
    <dbReference type="OMA" id="FQMSVEM"/>
    <dbReference type="OrthoDB" id="10262320at2759"/>
    <dbReference type="PhylomeDB" id="B8MMU1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1410.10:FF:000004">
        <property type="entry name" value="Cytoskeleton assembly control protein Sla2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000021">
        <property type="entry name" value="Cytoskeleton assembly control protein Sla2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035964">
        <property type="entry name" value="I/LWEQ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002558">
        <property type="entry name" value="ILWEQ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030224">
        <property type="entry name" value="Sla2_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407:SF15">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01608">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00307">
        <property type="entry name" value="ILWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="7">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="I/LWEQ" evidence="8">
        <location>
            <begin position="795"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="249"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="997"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED13847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1038" mass="118314" checksum="933DE7FED531510A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MN11</accession>
    <name>B8MN11_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_101960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486198.1">
        <property type="nucleotide sequence ID" value="XM_002486153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MN11"/>
    <dbReference type="GeneID" id="8099241"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_101960"/>
    <dbReference type="eggNOG" id="ENOG502RJ1A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_6_2_1"/>
    <dbReference type="InParanoid" id="B8MN11"/>
    <dbReference type="OMA" id="IETWSKE"/>
    <dbReference type="OrthoDB" id="4225981at2759"/>
    <dbReference type="PhylomeDB" id="B8MN11"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="49"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED13960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="466" mass="53257" checksum="E6E13C351FA0D89E" modified="2009-03-03" version="1">MASMELALAALRSADPREKPNISLVARTYGVSQSGLYKRFHGVTGSKEEQYDKQRILTTTQSRALIKWINQLTERGLPPTNSMLANFAREISGKEPGKNWASRWLKAHSDKVISRYSTGLDSDRKKADSAYKYALYFELIGRKIQQYNLGPEQIYNMDEKGFMLGVSTKRKRIFTRRKYEQGGYKQHLQDGNREWITTIGCICANGTALAPTFRTTGLYPFDPEIVINKFNKKITSRPSSSESGASIIPPEDWRRLEKLVKTVVNNIYDEKAVQLRETVSHLSTQLILLQNENQGLKRALINAKKPKNKKQPLLLGLPSEQDGGALFMSPTKVQQARDIISQKNDEAAQKQVHKDDKKLQQQLKKQAREAEKVKRAQIRQEKREQREQEAAEKQRLKDEQELAKLADLQLQNDVISTPKASKRPTKQISRQAKPRVQPEAHVEDNEVVVTTNRRGRAIRPPARFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNC6</accession>
    <name>B8MNC6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">xylan 1,4-beta-xylosidase</fullName>
            <ecNumber evidence="13">3.2.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSTA_102450</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of (1-&gt;4)-beta-D-xylans, to remove successive D-xylose residues from the non-reducing termini.</text>
            <dbReference type="EC" id="3.2.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="13"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486253.1">
        <property type="nucleotide sequence ID" value="XM_002486208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNC6"/>
    <dbReference type="STRING" id="441959.B8MNC6"/>
    <dbReference type="GeneID" id="8100822"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_102450"/>
    <dbReference type="eggNOG" id="KOG4157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_5_3_1"/>
    <dbReference type="InParanoid" id="B8MNC6"/>
    <dbReference type="OMA" id="WGFKGHV"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="PhylomeDB" id="B8MNC6"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000007">
        <property type="entry name" value="Exo-1,4-beta-xylosidase xlnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000013">
        <property type="entry name" value="Probable exo-1,4-beta-xylosidase xlnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF3">
        <property type="entry name" value="BETA-D-XYLOSIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877600" description="xylan 1,4-beta-xylosidase" evidence="14">
        <location>
            <begin position="23"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="15">
        <location>
            <begin position="44"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EED14015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="893" mass="95787" checksum="8A0C140DC895A551" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8MP18</accession>
    <name>B8MP18_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_104710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486495.1">
        <property type="nucleotide sequence ID" value="XM_002486450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MP18"/>
    <dbReference type="GeneID" id="8098692"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_104710"/>
    <dbReference type="eggNOG" id="ENOG502QTS6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058267_1_0_1"/>
    <dbReference type="InParanoid" id="B8MP18"/>
    <dbReference type="OrthoDB" id="4222915at2759"/>
    <dbReference type="PhylomeDB" id="B8MP18"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED14257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="143" mass="15415" checksum="5F30944C6EE3AA72" modified="2009-03-03" version="1">MWKSNNPFIASSCTQVNQPKPSDEEITNLHDAIQQVASETLVDRRFILAIILQESKGCLRVPTTSWGVSNPGLMQDHGGTGTCYGVNSYPKENIVQMVQDGTSGTKGGDGLVTLLDKGVTPCYASDIANRLTGWVSAEYACTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8MP54</accession>
    <name>B8MP54_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_105050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486531.1">
        <property type="nucleotide sequence ID" value="XM_002486486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MP54"/>
    <dbReference type="GeneID" id="8098726"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_105050"/>
    <dbReference type="eggNOG" id="ENOG502T2PH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058490_3_2_1"/>
    <dbReference type="InParanoid" id="B8MP54"/>
    <dbReference type="OMA" id="EHKEPDY"/>
    <dbReference type="OrthoDB" id="4226005at2759"/>
    <dbReference type="PhylomeDB" id="B8MP54"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED14293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="310" mass="35799" checksum="56705928230BA303" modified="2009-03-03" version="1">MSSTPSPEDFGLTPNTPVHKYQDVHHFSEMVFREFKLLQSRQDSSQYVIFTDLDQERFSRDFQDHTDALAIESYFPRLQILMAKIETVTHANAADDFGIMFMEKPCLMKIDRRQLIKISTASIETDERSKRADRAYKPRRLPKYRDQRWPTLVVEVGYTEVRRKLANDTRWWLTASNGDVKTVVTISINQKYREITFEKWGPNTEAPEQPVVLQSIQVQQDADLQHIKISGKCPLVLSFEAIFLRHPQTACETDIEFSQDELEKFAVDTWDVQAVFSQTFSRNTSPEFIAANCGIRASNLCLRATPPPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>B8MP85</accession>
    <name>B8MP85_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="16">ATP-PFK</shortName>
            <shortName evidence="16">Phosphofructokinase</shortName>
            <ecNumber evidence="16">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TSTA_105360</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 16">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16 17">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="16">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16 17">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion outer membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="16"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486562.1">
        <property type="nucleotide sequence ID" value="XM_002486517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MP85"/>
    <dbReference type="FunCoup" id="B8MP85">
        <property type="interactions" value="866"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MP85"/>
    <dbReference type="GeneID" id="8098757"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_105360"/>
    <dbReference type="eggNOG" id="KOG2440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011053_0_0_1"/>
    <dbReference type="InParanoid" id="B8MP85"/>
    <dbReference type="OMA" id="WHNLGGS"/>
    <dbReference type="OrthoDB" id="537915at2759"/>
    <dbReference type="PhylomeDB" id="B8MP85"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000010">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000007">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000008">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03184">
        <property type="entry name" value="Phosphofructokinase_I_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
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        </location>
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            <end position="562"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED12686.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="631" mass="72762" checksum="C7364C43E4305235" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8MR66</accession>
    <name>B8MR66_TALSN</name>
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        <recommendedName>
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        </recommendedName>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="216" mass="24827" checksum="3B9F7A8CF162CC8E" modified="2009-03-03" version="1">MIIDGWMFYYARSQAAIQAIDGAQKTGQQILGSIAEKWDELRSQGVQVTIHWIPAHQGIEGNERADIAAKEATGWRLVQNNRGRQVPLDMDSTAPRLVGLQQPLSALKRDLKTLAYKQWEQNWQQNQQGRTLFRVVDKPSKKNIELHTRLSRPLSSILTQMRTGNISLRHFLYKRKIPGIDNGECQCQRGAQTVTHILLSCPRFKEERNAWKNERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="29" xmlns="https://uniprot.org/uniprot">
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
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            <dbReference type="EMBL" id="EED13004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="183" mass="20710" checksum="B561963D7D377ED2" modified="2009-03-03" version="1">MVKRKENSESMKSNGTSQKCGVEISQIKVDDAFAILSACACTWASDRWSTPGKCASIRAVVGFLKKKQSQLSSPKQKHWVASHQMAVFNIVARMILEHRCSELFDVVSNDQPSFARFLEYLDRWSAQTQVEDFIVKQRKNVLGETDRGAVNAKANYAKALHRQGKFADTIARQREVLERENLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRU6</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">TSTA_057690</name>
    </gene>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000001745">
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    </dbReference>
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            <end position="132"/>
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    </feature>
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            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="297" mass="32022" checksum="6A933B55B91F5C3C" modified="2009-03-03" version="1">MARKGPGTDGPLQTALLESTSAATTRASKGQKIFSPIAAFLDKHRSQTTGLAPHLLRALTALSDDLALVAQQHFNAYISGILMISILPALSPSPSSSPTLNPLPPLPSPLRSPSVKSTSTTHPKASVKKPMPLVKQPHPNNWLFVRLLANYAARKMEAYTIYSSLQSQLNLNSAALKEVQATKTGFALCPSSPEALLALKAQKETISAFFVNCQIERSSRWISYRVTNVPRKIGQILDSQYSLIPVNPTLLSLEISETTGLKPISISETTTSAANPDTLSLSWFVNFLEGAKLPLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MS51</accession>
    <name>B8MS51_TALSN</name>
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            <fullName evidence="11">75k gamma secalin</fullName>
        </recommendedName>
    </protein>
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    </gene>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SCC4/mau-2 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002488065.1"/>
    </dbReference>
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    <dbReference type="STRING" id="441959.B8MS51"/>
    <dbReference type="GeneID" id="8104478"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_004940"/>
    <dbReference type="eggNOG" id="ENOG502RK5N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006541_1_1_1"/>
    <dbReference type="InParanoid" id="B8MS51"/>
    <dbReference type="OMA" id="QMVDICC"/>
    <dbReference type="OrthoDB" id="5565328at2759"/>
    <dbReference type="PhylomeDB" id="B8MS51"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019440">
        <property type="entry name" value="MAU2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21394">
        <property type="entry name" value="MAU2 CHROMATID COHESION FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10345">
        <property type="entry name" value="Cohesin_load"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="489"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="123"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="188"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="245"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="415"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED12456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1143" mass="127285" checksum="4E7EC31D05829200" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B8MS70</accession>
    <name>B8MS70_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_001960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487782.1">
        <property type="nucleotide sequence ID" value="XM_002487737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MS70"/>
    <dbReference type="GeneID" id="8098787"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_001960"/>
    <dbReference type="HOGENOM" id="CLU_2544158_0_0_1"/>
    <dbReference type="InParanoid" id="B8MS70"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED12128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="83" mass="9648" checksum="883B2CFCCFB73A1C" modified="2009-03-03" version="1">MDAPSNINDEISSLSRQIEQEEGAIEAVERLAQNASPKNWSTSRNKVRHLEKKLKNLQLIRDAPDWVVVFAQEQNDHDENWKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSH6</accession>
    <name>B8MSH6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">6-hydroxy-D-nicotine oxidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_000760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487658.1">
        <property type="nucleotide sequence ID" value="XM_002487613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSH6"/>
    <dbReference type="STRING" id="441959.B8MSH6"/>
    <dbReference type="GeneID" id="8108699"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_000760"/>
    <dbReference type="eggNOG" id="ENOG502RZAG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_1_2_1"/>
    <dbReference type="InParanoid" id="B8MSH6"/>
    <dbReference type="OMA" id="HHEFRTM"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="PhylomeDB" id="B8MSH6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF54">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877975" evidence="5">
        <location>
            <begin position="22"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="104"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED12004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="536" mass="57169" checksum="ECA5CBD6B9F6638A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSK7</accession>
    <name>B8MSK7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_003900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle</location>
            <location evidence="6">COPII-coated vesicle membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the VMA21 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487989.1">
        <property type="nucleotide sequence ID" value="XM_002487944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSK7"/>
    <dbReference type="FunCoup" id="B8MSK7">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MSK7"/>
    <dbReference type="GeneID" id="8100102"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_003900"/>
    <dbReference type="eggNOG" id="ENOG502SBNA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154717_1_1_1"/>
    <dbReference type="InParanoid" id="B8MSK7"/>
    <dbReference type="OMA" id="AMKEDQT"/>
    <dbReference type="OrthoDB" id="160405at2759"/>
    <dbReference type="PhylomeDB" id="B8MSK7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03058">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019013">
        <property type="entry name" value="Vma21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792:SF3">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09446">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Prevents secretion from ER" evidence="6">
        <location>
            <begin position="118"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED12335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="121" mass="12801" checksum="E711D5ABA7A11F56" modified="2009-03-03" version="1">MVLPGRRSRPNQRVSPPPSSSEKPDTSSVLAQGSTNIPGASDTSPAVPAETIYKLLAFTFAMICGPLGAYFLSIKTFFSGNSTLAGALAALTANVVLVAYVIVAWQEDKEDQAKQKEKKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTF0</accession>
    <name>B8MTF0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Cytochrome c oxidase subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Cytochrome c oxidase polypeptide VIIA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_002610</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the fungal cytochrome c oxidase subunit 7a family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487849.1">
        <property type="nucleotide sequence ID" value="XM_002487804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTF0"/>
    <dbReference type="FunCoup" id="B8MTF0">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MTF0"/>
    <dbReference type="GeneID" id="8102872"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_002610"/>
    <dbReference type="eggNOG" id="ENOG502SBM8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196969_0_0_1"/>
    <dbReference type="InParanoid" id="B8MTF0"/>
    <dbReference type="OMA" id="ASYWWWG"/>
    <dbReference type="OrthoDB" id="2317211at2759"/>
    <dbReference type="PhylomeDB" id="B8MTF0"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22888">
        <property type="entry name" value="CcO_VIIa_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014368">
        <property type="entry name" value="Cyt_c_oxidase_su7a_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000283">
        <property type="entry name" value="COX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED12195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="62" mass="7006" checksum="6B3FE6C7BC3ED1EA" modified="2009-03-03" version="1">MAAAIPPITGMLRRGLVLDLSTAFGLGTTFGYLWWYGYHLPRVRARDNHYARLEQERAAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTI8</accession>
    <name>B8MTI8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RecQ-mediated genome instability protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_004420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488048.1">
        <property type="nucleotide sequence ID" value="XM_002488003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTI8"/>
    <dbReference type="STRING" id="441959.B8MTI8"/>
    <dbReference type="GeneID" id="8100153"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_004420"/>
    <dbReference type="eggNOG" id="KOG3683">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093893_0_0_1"/>
    <dbReference type="InParanoid" id="B8MTI8"/>
    <dbReference type="OMA" id="MTSPDQI"/>
    <dbReference type="OrthoDB" id="341511at2759"/>
    <dbReference type="PhylomeDB" id="B8MTI8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049363">
        <property type="entry name" value="RMI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790:SF15">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1 RMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21000">
        <property type="entry name" value="RMI1_N_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01161">
        <property type="entry name" value="DUF1767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RMI1 N-terminal" evidence="5">
        <location>
            <begin position="12"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="4">
        <location>
            <begin position="70"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED12394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="245" mass="26803" checksum="793676E9FEC76B77" modified="2009-03-03" version="1">MSSTEEHIKSQLLSTKSLPVSPAWISNFLASLSQNQQRAPPSALAQTALFRILTTDFTKTLSTSTHSKLLPRDIFNPSVKERRISGPVPVQVLDVEDIGSKQVERGETIRGREIVRNVNVDGDNSANDETANNGSRSARNTTSNGPHRLILQDAAGTKIVALEYKDIDGVSVEKLCIGAKLVLKDITVARGIALLTPETVTLLGGKIESWDTTWRQKRKEVLLAKIEALHAEQNRGNANGDEMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUB8</accession>
    <name>B8MUB8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposable element tc1 transposase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_108120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488378.1">
        <property type="nucleotide sequence ID" value="XM_002488333.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488379.1">
        <property type="nucleotide sequence ID" value="XM_002488334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUB8"/>
    <dbReference type="STRING" id="441959.B8MUB8"/>
    <dbReference type="GeneID" id="8106876"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_108120"/>
    <dbReference type="eggNOG" id="ENOG502QUTZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_802103_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUB8"/>
    <dbReference type="OrthoDB" id="4737581at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="2">
        <location>
            <begin position="22"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED11622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="346" mass="39628" checksum="567816F89ED26781" modified="2009-03-03" version="1">MPNLPRPWQALTYFASKTGSPTSTELAQHLDLNCSKLAIKSALNSRGYYRYIARRKPPLSSINKAKRLRWAQEHINWTYNDWKTILWTDESWVLGNRHTRTWITRRKDEIYDDMCVVEHFISQYPHLSLMQDGAPGHGAQATQNKIREYGINMIYWPLYFLDLNPIEVVNFRDQMSTIELRIALQEAWDAVPEDFLVELVESMPERCKAVVEVGGGYTSTHNIRDSRKSRHPGGQRDASSQRLTHAYEEVPLSMNIPEDTERPSAILIIPPAYPTDQPPTTAQYVHWLNIDISALRPRLTVTIQTRANGGEPLDRKAWNAGGLLKAWLLSSQRQEVCIVISVLPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUZ0</accession>
    <name>B8MUZ0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_110110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488587.1">
        <property type="nucleotide sequence ID" value="XM_002488542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUZ0"/>
    <dbReference type="GeneID" id="8107243"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_110110"/>
    <dbReference type="HOGENOM" id="CLU_763284_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUZ0"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED11831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="363" mass="41151" checksum="B0EB94857EF862C8" modified="2009-03-03" version="1">MLGGGSQGKQDKEDDMQGGSILDSSPEGIFQRLLPIIQNVPGAYFEIRDFLIAQLDPNVADPVCKNTPLHHYASVRDLDIVRKLVARGANLYFRNIHNVSPLDLAVMNGDTDMVEVMCKEATEVMRTATKQKQNDPSNNELIKKFCWEKLNAYFGDVESFLKGLRDSDSIIYGDFPLWVLTQGKCSPEGKNLCLDIYSDTGGYWWLQSFLSLHGYGKERSALLFNGQPMIIWYNQERNKMVSVTKTENTTSINAVFSSIKTTGFANFITGRRIYCLFPYLTLQLHETYSWEKTNVEENSILAFAEHKCLSEASLKNQFLAKMFEDRSAGDEQTLRIGLYDGENGYVEKAQKHEKVFSVSEMTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>B8LT49</accession>
    <name>B8LT49_TALSN</name>
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        <recommendedName>
            <fullName evidence="2">P-type Ca(2+) transporter</fullName>
            <ecNumber evidence="2">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSTA_069750</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="2"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340944.1">
        <property type="nucleotide sequence ID" value="XM_002340903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LT49"/>
    <dbReference type="FunCoup" id="B8LT49">
        <property type="interactions" value="421"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LT49"/>
    <dbReference type="GeneID" id="8104671"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_069750"/>
    <dbReference type="eggNOG" id="KOG0202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_3_3_1"/>
    <dbReference type="InParanoid" id="B8LT49"/>
    <dbReference type="OMA" id="KMHACET"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="PhylomeDB" id="B8LT49"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140613">
        <property type="term" value="F:P-type manganese transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000031">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000040">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="365"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="898"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="938"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="979"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="15">
        <location>
            <begin position="37"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EED23557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1050" mass="113748" checksum="D8A1D75DCDB51BC1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8LT93</accession>
    <name>B8LT93_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc knuckle domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_070150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340988.1">
        <property type="nucleotide sequence ID" value="XM_002340947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LT93"/>
    <dbReference type="FunCoup" id="B8LT93">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LT93"/>
    <dbReference type="GeneID" id="8102398"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_070150"/>
    <dbReference type="eggNOG" id="KOG0314">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019105_1_0_1"/>
    <dbReference type="InParanoid" id="B8LT93"/>
    <dbReference type="OMA" id="NVPDHEP"/>
    <dbReference type="OrthoDB" id="106784at2759"/>
    <dbReference type="PhylomeDB" id="B8LT93"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16620">
        <property type="entry name" value="vRING-HC-C4C4_RBBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014891">
        <property type="entry name" value="DWNN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033489">
        <property type="entry name" value="RBBP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01180">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51282">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DWNN" evidence="9">
        <location>
            <begin position="5"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="97"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="361"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="575"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="390"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="575"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="593"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED23601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="644" mass="71087" checksum="11533D36C66F4C18" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTX3</accession>
    <name>B8LTX3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Ubiquitin fusion degradation protein UfdB, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_071990</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341191.1">
        <property type="nucleotide sequence ID" value="XM_002341150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTX3"/>
    <dbReference type="FunCoup" id="B8LTX3">
        <property type="interactions" value="1267"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LTX3"/>
    <dbReference type="GeneID" id="8105092"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_071990"/>
    <dbReference type="eggNOG" id="KOG2042">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8LTX3"/>
    <dbReference type="OMA" id="WLTEIAM"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="PhylomeDB" id="B8LTX3"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16657">
        <property type="entry name" value="RING-Ubox_UBE4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="13">
        <location>
            <begin position="994"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="513"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="946"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="22"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED23804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1082" mass="123006" checksum="4EB20FEA8814F0D1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTX9</accession>
    <name>B8LTX9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Endosomal cargo receptor (Erp5), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_072030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341196.1">
        <property type="nucleotide sequence ID" value="XM_002341155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTX9"/>
    <dbReference type="FunCoup" id="B8LTX9">
        <property type="interactions" value="500"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LTX9"/>
    <dbReference type="GeneID" id="8105098"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_072030"/>
    <dbReference type="eggNOG" id="KOG1690">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066963_2_1_1"/>
    <dbReference type="InParanoid" id="B8LTX9"/>
    <dbReference type="OMA" id="GATCAWQ"/>
    <dbReference type="OrthoDB" id="3427at2759"/>
    <dbReference type="PhylomeDB" id="B8LTX9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002874464" evidence="9">
        <location>
            <begin position="28"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="37"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED23809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="225" mass="25660" checksum="17E5049ED88179F0" modified="2009-03-03" version="1">MSATRTSPSWLLTLFTVFTVLSAQARALHVYMEGQQRKCFFEELPKDTLVVGTYKAEILNRESNIWVQDSSLQVLITVEETFDNDHRVVSQRTPSNGRFTFTAADAGQHRICFTPDSQSQGWLSSAPTVKLALDVAIGATSKIETEDSGKISDITQRVKDLNSRLEDIRREQVFQREREAEFRDQSEATNSRVVRWTLIQLAVLSITCAWQLSHLRSFFIKQKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUP0</accession>
    <name>B8LUP0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peroxin/Ferlin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_072870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341284.1">
        <property type="nucleotide sequence ID" value="XM_002341243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUP0"/>
    <dbReference type="STRING" id="441959.B8LUP0"/>
    <dbReference type="GeneID" id="8099997"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_072870"/>
    <dbReference type="eggNOG" id="ENOG502S2MG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028361_2_1_1"/>
    <dbReference type="InParanoid" id="B8LUP0"/>
    <dbReference type="OMA" id="RWQFLTH"/>
    <dbReference type="OrthoDB" id="72441at2759"/>
    <dbReference type="PhylomeDB" id="B8LUP0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051513">
        <property type="entry name" value="Tectonin_beta-prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23250">
        <property type="entry name" value="DYSFERLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23250:SF1">
        <property type="entry name" value="TECTONIN BETA-PROPELLER REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00694">
        <property type="entry name" value="DysFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peroxin/Ferlin" evidence="2">
        <location>
            <begin position="197"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED23897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="461" mass="53132" checksum="4936B37A5C842E42" modified="2009-03-03" version="1">MATDVAKGIDLVDNTKSQQPSEQDLSRSETRSSYFQLKQKLTRDSVRNELQKRKYAKWQRERLGAPDPESRSQSLSRTTTKNTTPGTPMPSKGFDNVDILNIAPVQTEATNILKTEENPEASSELEVLYENQRGWFLFGIPFYSSRSLLQFDPPAWVDKEYRVSPVNITNTQVPDPSWEWAWPTWYVDMSDDVDEEGWQYSFSFIPKSGWHGTHPWFHSYVRRRRWVRLRVKKKYARLKNGVDQTDFRMAHMLNEDYFTIHSQNLNSVDPSIAPPTAADVPSSSFSRQWVGDSPERHVEDSIENIPALLEAMKNAIVDRKKIEALRKFLAQGGEELYYLPDKVPEMLSLFVFQTSRWQFLKLLHDALDDANSLETDSNAGKKEIDAQDRRRNNILRTIDAVKKEVSDIGVFDISKENLESLYDSELHEAHRSSRGKGKERSWNEIKGIPKAAGIGKEGHIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUS7</accession>
    <name>B8LUS7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS monocarboxylate transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_073240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341321.1">
        <property type="nucleotide sequence ID" value="XM_002341280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUS7"/>
    <dbReference type="GeneID" id="8109408"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_073240"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="InParanoid" id="B8LUS7"/>
    <dbReference type="OMA" id="YHATTCI"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="PhylomeDB" id="B8LUS7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED23934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="455" mass="49307" checksum="B392F28F3750C93E" modified="2009-03-03" version="1">MEYELEHRSSHSSRTTHPGNGIDSLPLAIIHNDGNETSGIIEQQSLHPADTGTHAYLFLLSSFILEALIWGFAYTFGIFQQYYSTHPPFDSDKSNIAVIGTCSMGIIYIISPLVFGLLLGFPKLKRYSSALGLVLMIPALLGSSFANTTRQLLVSQGIVYAIGASFAYAPLILFMEEWFVKKRGFAFGIMWAGTGVSGVVLPLLMQWLMDTYGFRTTLRVWSAVLLVCIGPLLYFVKPRIPIAQSSSTRPFNLRFLRNGSFMIFQLGNIIQALGFFLPTIYLPTYATNTLGVNGVVSSLTVILFNLASVFGCIIMGAMVDRYHATTCILFSTIGSTISVFLIWGFSISLTPLLIFCVVYGIFAGSFSSTWPAIMREVKNRESSVEPAIVFAFLAAGRGIGNVASGPLSDGLLQGYPFQGVLGGAYGSGYGSLIVFTGVSALLGGLSVLARPLRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8LV29</accession>
    <name>B8LV29_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain type dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_061400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340037.1">
        <property type="nucleotide sequence ID" value="XM_002339996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LV29"/>
    <dbReference type="STRING" id="441959.B8LV29"/>
    <dbReference type="GeneID" id="8102539"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_061400"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_8_0_1"/>
    <dbReference type="InParanoid" id="B8LV29"/>
    <dbReference type="OMA" id="IHPGNVF"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="PhylomeDB" id="B8LV29"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF37">
        <property type="entry name" value="CLAVALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED22650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="303" mass="32831" checksum="B3F91853E87BF76D" modified="2009-03-03" version="1">MPPPRGTPNILEGPGDYDVTSIIHSESYPAIDSRQFDFSGKAIFVTGASRGLGCAMVLSFVRAGASFIAAGARSDMSHLAKDVATTAESTNREAPKFLAVNLNVADPKSVEDAAALVEREFGRIDIVINNAGLLGSHGGITDTDPEEWWNIMSVNLRGPYLVARSFLPMLVKSPNPYIIQVTSVAAHLLNPTLTAYQTSKASLLRFTQLIDAEYGKQGVTAFAIHPGNCPTDMMGGPGGLHDFEKHIFVDSSDLSADTIAFLTAEKRQWLGGRYINVTWDMPELVAKKDDIVQGDKLKNRFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVB9</accession>
    <name>B8LVB9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_066200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340556.1">
        <property type="nucleotide sequence ID" value="XM_002340515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVB9"/>
    <dbReference type="STRING" id="441959.B8LVB9"/>
    <dbReference type="GeneID" id="8102533"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_066200"/>
    <dbReference type="eggNOG" id="ENOG502SCIP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010004_1_0_1"/>
    <dbReference type="InParanoid" id="B8LVB9"/>
    <dbReference type="OrthoDB" id="4509841at2759"/>
    <dbReference type="PhylomeDB" id="B8LVB9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="54228" checksum="54DBFE565D9B663C" modified="2009-03-03" version="1">MVPSVGLSSGGSLPSTPYPSQEDLEVYLEHTDPNILNPIRRFPDKVVEKENLVIHSTQDTTIAHRRIAAACILSSGDIILLLGTVDDVDQLTCKKDWIRAFGNEAHIQKCTWGVVVHGVNTNINPKQPQFITTLTSENAPVFAQLPASMNVTHTGWLLSEYKIKEQKLTNAHLVVIFNDERIANFVIQCGLIIKGRQHNVLIYDKVANLQQCFKCQMYKHIARHCQRQICCAYCAGSHDTGDCPTPKEKEYAKCANCTAENVHIKDPAKRLNMKHFAYARECPIRATCLAEAHQRRIYDPQYHTPPGAISPNDPTPAEAANTERSPRAPARIATTRQSANSRKRSEPEPISPTSGDPTNRSSKKPRRAQWDKDLVIDVDPNPEPKTGPETQIKYTYNTRARQNTKPPPGTPVLQSDIAPLEISHVQAVRTVRQSKSVRTIPDDDSSEDELTQPSIHEAPQEPIEPAQEADTLMTTNLEDSTWANNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVV1</accession>
    <name>B8LVV1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_076820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341704.1">
        <property type="nucleotide sequence ID" value="XM_002341663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVV1"/>
    <dbReference type="GeneID" id="8110216"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_076820"/>
    <dbReference type="eggNOG" id="ENOG502S0KS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_543123_0_0_1"/>
    <dbReference type="InParanoid" id="B8LVV1"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="PhylomeDB" id="B8LVV1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025255">
        <property type="entry name" value="DUF4202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41729">
        <property type="entry name" value="GLUTAMYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41729:SF1">
        <property type="entry name" value="GLUTAMYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13875">
        <property type="entry name" value="DUF4202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED24317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="502" mass="56070" checksum="AB9EEC0774C2C440" modified="2009-03-03" version="1">MTEAQRPFSSFRLLSFDIYGTLIEWEKGILQAASPIRERLLDSSPLKRDDIAFGAVFNKHEARLQAAHPGMTYDKILRNAYIAVAKEILMHGDSLPGEDHLQAEGVAFAESIKNWPAFPDTVEAMRKLKRLGFKLVPLSNVDHGSFGKTLAGPLGGLKEPLTPGSEPLDPFFDAVYTAQDIGSYKPDLRNFEYLISHVKAEFGVEKHEILHVAQSLTHDHVACKQIGLTSVWIARGENGKSGMGGDAQELMGKVSFAWKFKSLREFADAGNILLISEAAGRKAEMSDKFHRALSAIDEAHSQDPKGPGPYRLDNHRNKINPLRTSLCPKNDSYLDSYNPSASELLRLAIRAQHLRRWEVPRSSYPATKAGYLNWRTFLKNRQADQARQICLDAGYSPEEAGRVASLVRKEGLKRRAVETTANTTVDKGAESEEDETQILEDVACLVFLDDQFAAFEKGLDEEKILGILRKTWAKMSDKGRRMALEIQMSDRCRELVQKALSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8LW02</accession>
    <name>B8LW02_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aha1 domain family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_077340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341755.1">
        <property type="nucleotide sequence ID" value="XM_002341714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LW02"/>
    <dbReference type="FunCoup" id="B8LW02">
        <property type="interactions" value="1361"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LW02"/>
    <dbReference type="GeneID" id="8101987"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_077340"/>
    <dbReference type="eggNOG" id="KOG2936">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8LW02"/>
    <dbReference type="OrthoDB" id="567237at2759"/>
    <dbReference type="PhylomeDB" id="B8LW02"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08892">
        <property type="entry name" value="SRPBCC_Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.20">
        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036338">
        <property type="entry name" value="Aha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015310">
        <property type="entry name" value="AHSA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="ASHA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 HSP90 CO-CHAPERONE AHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009:SF22">
        <property type="entry name" value="LD43819P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09229">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01000">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103111">
        <property type="entry name" value="Activator of Hsp90 ATPase, Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Activator of Hsp90 ATPase AHSA1-like N-terminal" evidence="4">
        <location>
            <begin position="13"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED24368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="385" mass="43014" checksum="5E71E327AC94F71F" modified="2009-03-03" version="1">MALHNPNNWHWVNKDVAPWTKTYLQDTLSKISAEEDGVSAKVEKVLSMDGDVDVSQRKGKVITLYDVKLQLEYEGKTKDDETVTGTITIPEVAHDTEEDEFVFEISVYSESSSKQPVKDLVRSKIVPQIRTALAKLPKVLVEEHGKDIQHAPGSNPSSGFATPTYHSHKSPSPAAGTPKTTTTSTGKVAVNTTTVTASDEFRTTAEEMYTTFTDPQRIAAFTRGPPRQFEGAKIGGKFAIFDGNVTGEYITLEPSKRVVQKWRLAQWPEGHFSTQEIVFDQNDVDRVTVMRVTWTGVPIGQEEVVQRNWEGYYVRSIKQTFGYSPPSSFASTITTTVPRNPHLPSAASSSYQFSLMRRLLMFVFVLFLGIGLARYSDQILKFFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWX0</accession>
    <name>B8LWX0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_079580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341990.1">
        <property type="nucleotide sequence ID" value="XM_002341949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWX0"/>
    <dbReference type="STRING" id="441959.B8LWX0"/>
    <dbReference type="GeneID" id="8105100"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_079580"/>
    <dbReference type="eggNOG" id="KOG2741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_5_2_1"/>
    <dbReference type="InParanoid" id="B8LWX0"/>
    <dbReference type="OMA" id="EEAFHWQ"/>
    <dbReference type="OrthoDB" id="6417021at2759"/>
    <dbReference type="PhylomeDB" id="B8LWX0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="37"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="162"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED24603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="400" mass="45288" checksum="E4C7BF4903E5E09E" modified="2009-03-03" version="1">MALVLQAYTFAQQYVASYLHPTPTKSPMGLKLGVISTAQINPAAIIHPAETHPDVILYGIASRDLETAKQAAQKYNFKKAYGSYQDLIDDPEIDFVYISTPNGLHYEWASKALRAGKHVLCEKPFTSNAEEARKLVELAKVKGLVCEEAFHWQFHPSAHLFREILDSGRYGRILRTSAIMTASPGVPDGDIRWQFELSGGSSMDMTYALSFTRFAVHGAKLKEVQSAVARPYAQDKRVDEAMHSLILFEDPKDGHLIQSRIYTDMARQWVIKKIVPRVWEFPSIEVETDKAIIYYYNAMMPHLYHYISITDKTTGKTEYKKQYKGGPCWGESWTTGGKGGKAYWSTYRYQLEAFTEKVRGKHVPYWISGEESIAQMEAIDAIYKIAGLPTRPSVSKEMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B8LX43</accession>
    <name>B8LX43_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ankyrin repeat-containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_061810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340080.1">
        <property type="nucleotide sequence ID" value="XM_002340039.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LX43"/>
    <dbReference type="GeneID" id="8109410"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_061810"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_2_1"/>
    <dbReference type="InParanoid" id="B8LX43"/>
    <dbReference type="OMA" id="TIMEMAM"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="PhylomeDB" id="B8LX43"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055497">
        <property type="entry name" value="DUF7069"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23239">
        <property type="entry name" value="DUF7069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="6">
        <location>
            <begin position="389"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7069" evidence="5">
        <location>
            <begin position="589"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="4">
        <location>
            <begin position="678"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="891"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="927"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="957"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="993"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1026"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1059"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1092"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1125"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1155"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1248"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1289"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1330"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1363"/>
            <end position="1392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED22693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1417" mass="157099" checksum="DD03D03ABC02202C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXP0</accession>
    <name>B8LXP0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein transport protein yos1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_078980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the YOS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341928.1">
        <property type="nucleotide sequence ID" value="XM_002341887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXP0"/>
    <dbReference type="FunCoup" id="B8LXP0">
        <property type="interactions" value="280"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LXP0"/>
    <dbReference type="GeneID" id="8109436"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_078980"/>
    <dbReference type="eggNOG" id="KOG4779">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152125_0_0_1"/>
    <dbReference type="InParanoid" id="B8LXP0"/>
    <dbReference type="OMA" id="VQTVMRM"/>
    <dbReference type="OrthoDB" id="15356at2759"/>
    <dbReference type="PhylomeDB" id="B8LXP0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013880">
        <property type="entry name" value="Yos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858:SF0">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08571">
        <property type="entry name" value="Yos1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED24541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="86" mass="9529" checksum="71FFB72AB57C218E" modified="2009-03-03" version="1">MLFFGFGRLIYVTVLLINAVAVLSEDRFLARIGWGQAQPEPGFGSSYDNSSIKARTVNLITSVRTVMRIPLIVINTVIIVYELILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8LY14</accession>
    <name>B8LY14_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_067010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340646.1">
        <property type="nucleotide sequence ID" value="XM_002340605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LY14"/>
    <dbReference type="STRING" id="441959.B8LY14"/>
    <dbReference type="GeneID" id="8102509"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_067010"/>
    <dbReference type="eggNOG" id="ENOG502S5IR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1235758_0_0_1"/>
    <dbReference type="InParanoid" id="B8LY14"/>
    <dbReference type="OrthoDB" id="4230245at2759"/>
    <dbReference type="PhylomeDB" id="B8LY14"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="224" mass="25144" checksum="4CF13E26B4904732" modified="2009-03-03" version="1">MAKKETDDEEFHAKKAENDAITAKVKHEEAERQAELDRSAPLSETPNVSLPPEIPTYPDDDLVIRTSSIPETNEDCKFLDAPSSLDEEIEDSGDDGVEPDFKVEDEDDLNPFGGLDEEISKLIKPGSPSSEVSFRLSSSTRPSPVPLNTGELEPEFKWASHMQLITFRATAGKIAEEYLKGKSVKLHHQSVRSREIRNWHAYNQGVKDSKNIDVRRKRIEESAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8LY64</accession>
    <name>B8LY64_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate pyruvate transaminase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamic--alanine transaminase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamic--pyruvic transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_067460</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340696.1">
        <property type="nucleotide sequence ID" value="XM_002340655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LY64"/>
    <dbReference type="FunCoup" id="B8LY64">
        <property type="interactions" value="504"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LY64"/>
    <dbReference type="GeneID" id="8102511"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_067460"/>
    <dbReference type="eggNOG" id="KOG0258">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8LY64"/>
    <dbReference type="OrthoDB" id="1732682at2759"/>
    <dbReference type="PhylomeDB" id="B8LY64"/>
    <dbReference type="UniPathway" id="UPA00528">
        <property type="reaction ID" value="UER00586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1970:FF:000001">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000012">
        <property type="entry name" value="alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000010">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045088">
        <property type="entry name" value="ALAT1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751">
        <property type="entry name" value="ALANINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751:SF29">
        <property type="entry name" value="ALANINE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="156"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED23309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="530" mass="59164" checksum="9125AB1D8154F53E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYC3</accession>
    <name>B8LYC3_TALSN</name>
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        <recommendedName>
            <fullName evidence="1">Utp8 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_063330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340239.1">
        <property type="nucleotide sequence ID" value="XM_002340198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYC3"/>
    <dbReference type="STRING" id="441959.B8LYC3"/>
    <dbReference type="GeneID" id="8103872"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_063330"/>
    <dbReference type="eggNOG" id="ENOG502S1FV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013566_0_0_1"/>
    <dbReference type="InParanoid" id="B8LYC3"/>
    <dbReference type="OMA" id="GGWLFND"/>
    <dbReference type="OrthoDB" id="5330858at2759"/>
    <dbReference type="PhylomeDB" id="B8LYC3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018843">
        <property type="entry name" value="Utp8_b-prop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10395">
        <property type="entry name" value="Utp8_b_propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Utp8 beta-propeller" evidence="1">
        <location>
            <begin position="9"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="915" mass="99209" checksum="FE101E6F07EE994C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYG6</accession>
    <name>B8LYG6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Elongation factor-like 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_063710</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340282.1">
        <property type="nucleotide sequence ID" value="XM_002340241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYG6"/>
    <dbReference type="FunCoup" id="B8LYG6">
        <property type="interactions" value="804"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LYG6"/>
    <dbReference type="GeneID" id="8103930"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_063710"/>
    <dbReference type="eggNOG" id="KOG0467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_3_1_1"/>
    <dbReference type="InParanoid" id="B8LYG6"/>
    <dbReference type="OMA" id="FARCDIQ"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="PhylomeDB" id="B8LYG6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16268">
        <property type="entry name" value="EF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000006">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000002">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056752">
        <property type="entry name" value="EFL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25118">
        <property type="entry name" value="EFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="17"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="766"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="766"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED22895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1081" mass="119271" checksum="2F8B7F298336950B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYJ9</accession>
    <name>B8LYJ9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NWD NACHT-NTPase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_067860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340744.1">
        <property type="nucleotide sequence ID" value="XM_002340703.1"/>
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    <dbReference type="AlphaFoldDB" id="B8LYJ9"/>
    <dbReference type="STRING" id="441959.B8LYJ9"/>
    <dbReference type="GeneID" id="8105635"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_067860"/>
    <dbReference type="HOGENOM" id="CLU_1908100_0_0_1"/>
    <dbReference type="InParanoid" id="B8LYJ9"/>
    <dbReference type="OrthoDB" id="4497594at2759"/>
    <dbReference type="PhylomeDB" id="B8LYJ9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="15057" checksum="1B0004EF15445309" modified="2009-03-03" version="1">MGLREFFKSHKNMKGKTGRTQESSSNTTLTVNSSYANRDSWDEAYDALRTENEDLIRKVLLSRHRNRSSRREEQLRQVVTTVVDEVDLAKWQTKAGSHSFILRGQFDQAVKIVIASKDFISSAVSSDPHAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZG1</accession>
    <name>B8LZG1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7707 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_089510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478677.1">
        <property type="nucleotide sequence ID" value="XM_002478632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZG1"/>
    <dbReference type="STRING" id="441959.B8LZG1"/>
    <dbReference type="GeneID" id="8104918"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_089510"/>
    <dbReference type="eggNOG" id="ENOG502SSWV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084512_1_0_1"/>
    <dbReference type="InParanoid" id="B8LZG1"/>
    <dbReference type="OMA" id="CSAQRNT"/>
    <dbReference type="OrthoDB" id="2121879at2759"/>
    <dbReference type="PhylomeDB" id="B8LZG1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056124">
        <property type="entry name" value="DUF7707"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38118:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38118">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24808">
        <property type="entry name" value="DUF7707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002874630" description="DUF7707 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7707" evidence="2">
        <location>
            <begin position="28"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED21714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="200" mass="20534" checksum="D3599806A59BF1D5" modified="2009-03-03" version="1">MRSSAVLILAAFVAETTAYYNFTFPTGFNLGEVSSTILGQWCQGERNTCPQVCGGSASANDCDSTTLNFDCTCSNGTTPDLNPYENTIPFYVCQENYKQCIQNNPNDLDAQKQCKANATCGTIILDAASSTSAAPSTTSAVSTAAATTIATTTSAASATKASGTAASATTSHGVASLQISADHATGFFAAAMLAVFGMMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0A7</accession>
    <name>B8M0A7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferric reductase NAD binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_084350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478167.1">
        <property type="nucleotide sequence ID" value="XM_002478122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0A7"/>
    <dbReference type="STRING" id="441959.B8M0A7"/>
    <dbReference type="GeneID" id="8101528"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_084350"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010365_8_1_1"/>
    <dbReference type="InParanoid" id="B8M0A7"/>
    <dbReference type="OMA" id="ANCSARW"/>
    <dbReference type="OrthoDB" id="4226077at2759"/>
    <dbReference type="PhylomeDB" id="B8M0A7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF26">
        <property type="entry name" value="FAD-BINDING 8 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric reductase NAD binding" evidence="4">
        <location>
            <begin position="343"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED21204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="476" mass="54085" checksum="5F240173A93A873A" modified="2009-03-03" version="1">MDSIQIYAAAIGGILLLLLAQSMIRQLGYRIMFLSRLARFFAHITQRPWFFFLKHFVYSFILKRKTFIGPISRSEFIAQLIYWGGTATCNMFKVTTTSAAGTRAGQLAVVNLALLFFGRRFELLSDLLGIQSATYRRIHQTVGLMTCLQGSVHALLNIRRAISTSYELGSPKAEVDNTAGSSWYGSDFLHSSNESMLCVYYKTPFYLEHLCVGDALASLTGEKYFIVALRNVSASRIGCRAEILRSRDKSAAQIMILLNRPFKVRAGMSLHIWIPGLGIRSFFGSHSFPIAWWENDMQGRAKVISLLVKPKSGFTKRLLYSKPHQLRTFIEGPYGVPIDFLGYDRILMVATGIGIAAQLSYLKELVGMKDEKRSTRTLYVVWQVDDESNLDWVHQWMDQLLLMDRGVYMLKFGIYVPPSDNEAPTAWNSEHNRIWKIPGTINPEKIVGNWWSDNGKALITVLILQQFLQIKKFVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0K2</accession>
    <name>B8M0K2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adenosine deaminase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_085300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478262.1">
        <property type="nucleotide sequence ID" value="XM_002478217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0K2"/>
    <dbReference type="FunCoup" id="B8M0K2">
        <property type="interactions" value="610"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M0K2"/>
    <dbReference type="GeneID" id="8106136"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_085300"/>
    <dbReference type="eggNOG" id="KOG1097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039228_7_0_1"/>
    <dbReference type="InParanoid" id="B8M0K2"/>
    <dbReference type="OMA" id="RSNWIFC"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="PhylomeDB" id="B8M0K2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043103">
        <property type="term" value="P:hypoxanthine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="ADENINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114:SF7">
        <property type="entry name" value="ADENOSINE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="4">
        <location>
            <begin position="73"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED21299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="422" mass="48481" checksum="8A8814F07ABA4B7B" modified="2009-03-03" version="1">MVEPVYRIAPNCQGAKFIVSRGGRRDPILSCRIWLMGAVMEKFAVRGDYSEYPSEISQIMNGLEISPFITELPKVELHIHIEGTLTPALRWKLAHRNNIPLPYATYEELLDSYKVTYNHRREVNGDNGAPTFLEAYFAGCQVLCTEEDFYELAMDYFRKAREMNVRYVEPFFDTQAHTKRGIPASVVMNGFLRAKHDGAKFYNVRSNWIFCFLRDESLESGLEAYRTARPWAKTKDGKGKGLFHAVGLASNEYDRPPLLFEEGFRLAKEDGLHVTMHCDVDQKDAVDHVHEAIFQVCGGKGSERIDHGLNAVDREDLIVGLKERNIGLTLCPHAYHRRQATHILFPKIRKLWDEGVKICINSDDPTYMHNVWIDGNMMKVYEYCQFSKADMAQLVRNAVEVSWAEEEVKEEILEELEGFVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8M111</accession>
    <name>B8M111_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_090300</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478754.1">
        <property type="nucleotide sequence ID" value="XM_002478709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M111"/>
    <dbReference type="STRING" id="441959.B8M111"/>
    <dbReference type="GeneID" id="8108118"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_090300"/>
    <dbReference type="eggNOG" id="KOG0923">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_7_0_1"/>
    <dbReference type="InParanoid" id="B8M111"/>
    <dbReference type="OMA" id="PLDPMMS"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="PhylomeDB" id="B8M111"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000726">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
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    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF07717">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="499"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="688"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="109"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="112"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="239"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED21791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1137" mass="129129" checksum="2AB603BF662BCFD3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8M127</accession>
    <name>B8M127_TALSN</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="8104840"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_082020"/>
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    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
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    <dbReference type="OMA" id="WFATVIA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="AA-permease/SLC12A_dom"/>
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        <property type="entry name" value="APC_YAT"/>
    </dbReference>
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        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF39">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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        </location>
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        <location>
            <begin position="239"/>
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        </location>
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            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
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        <location>
            <begin position="46"/>
            <end position="379"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="475" mass="50951" checksum="99EF5F1AD1CF6250" modified="2009-03-03" version="1">MEDGKRIEGPVVLKPANNGDSDCTVGQMDTQSDRFGHVERRLKSRHIQFMALGGAIGTSLFLGIGSSLSTAGPANPLLGFTISGLAVCGMMLSLGEMTTWLPIPGAIPTFCSRYVDEALGFAVGWNNWYFASIVVCLEISAASVVIDYWPGAQGISPAVWITIIIIFILVLNVSAVGIFGEAEFVFTSIKLIAIIGLIILSVIVMAGGASNHEAIGFKYWNNPGAMNELSPATGAEGCFLAFFSVLVYACFTYAGVEMLAAAGGETQNPRVNMPIAFRRVAYRIVGFYVLGTLFVGCIVASNDPNLLTALAHNASGAAESPWVIGIQNAGITVLPSIINAVILTSAVSSANAMLYTGSRYLYSLARVGQAPRVLLYCIKNFYLTINVYDCFSRWFNCLSLGMNSTHPGRIAQQIAMLVTDLESAFYISWKLLKRTKVHPLEDVDLVTGKAEIDALDGDLGTEHPKTLAARLVKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8M138</accession>
    <name>B8M138_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LEA domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_082130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
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        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
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            <end position="20"/>
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    </evidence>
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            <dbReference type="EMBL" id="EED20980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="46228" checksum="5EFE47E49D33C131" modified="2009-03-03" version="1">MYVDTSKPPPPLPSPRCTEVSSGVSMLQPLSRRGTGPGMILIVPDAPQSNLSIINGVPSPLIKWAEESYVVVEIQERAMSSEGILQRATQAIFRSEDCVPKEKVGIVVYNGRLWDLVAPLLSSTTEISGAVIYASPDDKSPLSASPIPCLIHLTGKPSYSTTENKNIPPNRLYTYPSAKSSSFALPFQDDFSYSLEALSHTRNLTFFKPLMNGPYFDLEQIWDEHTYFEFENRSVQWTMSTMVQEPYVNHIPTMTGGVGREKLTHFYTNHFIFSNPADAELEVISRTVGIDRVVDEFIYKVTHNREIDWLIPGIPETGKKLEIPMTAIVNIRGDRLYHEHIAWDQGTVLSQVGLMPEYVPFPYRIAGDAPADGRYFEVKVPVAGMTTAMKVRDRNAVESNGLFEYKVREIGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1Q1</accession>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_002479056.1"/>
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    <dbReference type="STRING" id="441959.B8M1Q1"/>
    <dbReference type="GeneID" id="8103712"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_093840"/>
    <dbReference type="eggNOG" id="ENOG502S7KY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009271_1_0_1"/>
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    <dbReference type="OMA" id="PAEEWMG"/>
    <dbReference type="OrthoDB" id="2504266at2759"/>
    <dbReference type="PhylomeDB" id="B8M1Q1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046784">
        <property type="entry name" value="Eap1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20566">
        <property type="entry name" value="Eap1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="22"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="744"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="810" mass="88944" checksum="479A870DF88F6609" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1R8</accession>
    <name>B8M1R8_TALSN</name>
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        <submittedName>
            <fullName evidence="9">Efflux pump antibiotic resistance protein, putative</fullName>
        </submittedName>
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        <name evidence="9" type="ORF">TSTA_094010</name>
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        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002479073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1R8"/>
    <dbReference type="GeneID" id="8103729"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_094010"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_880471_0_0_1"/>
    <dbReference type="InParanoid" id="B8M1R8"/>
    <dbReference type="OMA" id="HAGKEHR"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="PhylomeDB" id="B8M1R8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF177">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="44"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED22155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="316" mass="33124" checksum="7DFD7682C53AF063" modified="2009-03-03" version="1">MSLSTPPPPLPEDGRLEAIGEKTHQVEPEKQKQKQTETVESNEPSIVASSSTVNGREKPGMLEDDGTATQEKGVDEPQPPKSVAFPKGVEAFVIVLALVLSMGLMSLDQTIVATAIPKITDQFNKINDVACFVVSIFIFELGSLICAVAPNSTTLIVGRAITDLGASGIASGVYTIAAFAAEPRKRATWMGIIGAAYGVTAVLGPLIGGGLRMGCPGGGESKMLCFYINLPIGGLAAFVILLTFKTPATAKRVDATLKEKLLHMDFPGTVLIMGASIALLLALQYGGVTHAWNSSVVIGLLVGFVVMVLALMMVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8M284</accession>
    <name>B8M284_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_087840</name>
    </gene>
    <organism evidence="2 3">
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        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052391">
        <property type="entry name" value="E3_Ligase-Neurotoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24133">
        <property type="entry name" value="ANKYRIN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24133:SF40">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="7"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="73"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="158"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="191"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="224"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="323"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED22366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="412" mass="45225" checksum="F014183F6B4E4405" modified="2009-03-03" version="1">MECTDDLGQTPLLLAAQNGHDAVIDILLDKGANIEYTDKSGRTPLLLAAQNGHDAIVNILLDKGANIECTDEYGRTPLLLAAQNGHEAIFNTLLGKEPILTQNGHEVVVNTLLDKGANIECADKSSQTPLLLAAQNGHETVVNTLLQKYANIECADGSGQTPLLLAVRNKHSPLSLQLLGKGANPNSKDSVGLTPMFWASTHGQASVIRLLLKKGANLQPTDCIGWRPMSIAAKKGHTDVVKLLLERGAITEATDKFGQTALLLAIRHGHGEIVEQFLDHNKKSAPKEPERPPEPKPSDTLSRPTKSSGNMLNACVLELDVILDEAYKQLRKEDEKLIEAYENDLLDQLEQIEPGTDRDMRLRKLVEQRIHSIQNSQLEFTVGRKEIVVRDQARRVIHTMLGFKNFITTAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3W0</accession>
    <name>B8M3W0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="4 14">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSTA_039070</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="4 14"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481137.1">
        <property type="nucleotide sequence ID" value="XM_002481092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3W0"/>
    <dbReference type="STRING" id="441959.B8M3W0"/>
    <dbReference type="GeneID" id="8107949"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_039070"/>
    <dbReference type="eggNOG" id="KOG0786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_3_1"/>
    <dbReference type="InParanoid" id="B8M3W0"/>
    <dbReference type="OMA" id="FRYSLDM"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="PhylomeDB" id="B8M3W0"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF4">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="6"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EED20703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="378" mass="40418" checksum="EA70F44B3B54A826" modified="2009-03-03" version="1">MAEIRKLLVLPGDHIGPEIIAEALKILAVLEEELPNFKVQISYGLIGGASLDKTGSAITDEVLETAVASDAVLLGSVGGPEWAHVPGALSPEKGILHLRQRLDAFANIRPCRFYASSLLNQSPLKPEIAAGVDFVLVRENCGGAYFGTKTEFEDEARTEVERCARVSAALARTFGRGKNTDDKSPAIVWNADKANVLASGRFWRTVTHDIFEREFPDIELHDQLADSMAMVMVKAPTKFNGVIHTDNTFGDILSDISGGIVGSLGVLPSASVCGVPGSEKPVKGIYEAVHGSAPDISGTGQANPIAQILSLAMLLRYSFSMPRQADLLEDAVRKTLEVREHGGLGIRTKDLGGSASTQDVGDAVAFQFRTLLRSADIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4J3</accession>
    <name>B8M4J3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sialidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_025100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479622.1">
        <property type="nucleotide sequence ID" value="XM_002479577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4J3"/>
    <dbReference type="STRING" id="441959.B8M4J3"/>
    <dbReference type="GeneID" id="8106727"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_025100"/>
    <dbReference type="eggNOG" id="ENOG502R6VZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020422_0_0_1"/>
    <dbReference type="InParanoid" id="B8M4J3"/>
    <dbReference type="OMA" id="PTRGMHD"/>
    <dbReference type="OrthoDB" id="5300765at2759"/>
    <dbReference type="PhylomeDB" id="B8M4J3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="528"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="549"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="676" mass="73753" checksum="2AA33BF609836798" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4R5</accession>
    <name>B8M4R5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flavoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_026580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479784.1">
        <property type="nucleotide sequence ID" value="XM_002479739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4R5"/>
    <dbReference type="STRING" id="441959.B8M4R5"/>
    <dbReference type="GeneID" id="8098939"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_026580"/>
    <dbReference type="eggNOG" id="KOG0672">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033319_3_0_1"/>
    <dbReference type="InParanoid" id="B8M4R5"/>
    <dbReference type="OMA" id="KGLACGD"/>
    <dbReference type="OrthoDB" id="1532798at2759"/>
    <dbReference type="PhylomeDB" id="B8M4R5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED19350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="237" mass="25513" checksum="C93F85FF0731EB17" modified="2009-03-03" version="1">MGTNPAESVAAAINDGKTHLLLAASGSVATIKIPLIISALRRHTNLSIRVILTKSASFFLQGQSAEQPTIASIAALPNVDAIYQDEDEMTESWVRGAGILHINLRKWADILVIAPLSANTLAKIVNGLSNNLLTDVIRAWDTSGLVDGGARKRILVAPAMNAAMWLQPITKKHILVLDKEWGVEADDGTLEHQGWFEVLKPIEKSLACGDVGVGGMMEWTNIVKIIEQRLGLVAPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5E3</accession>
    <name>B8M5E3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_030180</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480183.1">
        <property type="nucleotide sequence ID" value="XM_002480138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5E3"/>
    <dbReference type="FunCoup" id="B8M5E3">
        <property type="interactions" value="393"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M5E3"/>
    <dbReference type="GeneID" id="8106585"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_030180"/>
    <dbReference type="eggNOG" id="KOG0934">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061221_1_3_1"/>
    <dbReference type="InParanoid" id="B8M5E3"/>
    <dbReference type="OMA" id="ETMAEYM"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="PhylomeDB" id="B8M5E3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048203">
        <property type="term" value="P:vesicle targeting, trans-Golgi to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000007">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="13"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED19749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="136" mass="15763" checksum="36CD4696CB91A1FF" modified="2009-03-03" version="1">MTQLSDSPIAPRQSEKAKIVKDVSQLVLSRRTRMCNFLEYKDQKVVYRRYASLFFIAGCSATDNELISLEIVHRYVEQMDKYYGNVCELDIIFNFQKAYFILDELLLAGEMQESSKKNVLRCISQQDSLEDIEVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6A8</accession>
    <name>B8M6A8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M50B-like-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_025980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479717.1">
        <property type="nucleotide sequence ID" value="XM_002479672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6A8"/>
    <dbReference type="STRING" id="441959.B8M6A8"/>
    <dbReference type="GeneID" id="8108010"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_025980"/>
    <dbReference type="eggNOG" id="ENOG502QPXP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066780_0_1_1"/>
    <dbReference type="InParanoid" id="B8M6A8"/>
    <dbReference type="OMA" id="LSVNHTQ"/>
    <dbReference type="OrthoDB" id="40823at2759"/>
    <dbReference type="PhylomeDB" id="B8M6A8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049500">
        <property type="entry name" value="Peptidase_M50B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979">
        <property type="entry name" value="OS02G0221600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979:SF2">
        <property type="entry name" value="PEPTIDASE M50B-LIKE-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13398">
        <property type="entry name" value="Peptidase_M50B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="28868" checksum="B22C87BFB5643099" modified="2009-03-03" version="1">MAPTPAYFHDLANSMIVRRSLTNVNHTQAVTLGIIAVYVVVIALLWNLPYIRWSLWPFKMLVIAFHEFGHAITAVCTGGRVKSISLDPHEGGVTHMVGGKSAITLPAGYLGSSLIGALLIFCGFDIVASKIASIVLGVCFLLTLWWARKDWLTIVTILLAVGLLIGFWFIAHAEALRFLVLFIGVMSCLYSAWDICDDLILRKVNTSDASVFAKRYGGSSQCWGVIWSLVSVAFMAAAIVAGLAAFNQSFAQQESDSSHFIPTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8M715</accession>
    <name>B8M715_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_034720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480669.1">
        <property type="nucleotide sequence ID" value="XM_002480624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M715"/>
    <dbReference type="STRING" id="441959.B8M715"/>
    <dbReference type="GeneID" id="8104314"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_034720"/>
    <dbReference type="HOGENOM" id="CLU_1620182_0_0_1"/>
    <dbReference type="InParanoid" id="B8M715"/>
    <dbReference type="OrthoDB" id="4510599at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF16">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHASE ATNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED20235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="164" mass="18502" checksum="BB0ECD135DBF65E7" modified="2009-03-03" version="1">MNLDDNRFEDSHGTRQSTDFAENKQAKTKGSSVLDKEERRKWTEMQHCPDSSFLRVQSSQIEDAFPCTPLQEGLLALSAHLPGYYVAQYKLQLRPDVDDVALQATWSHAYATTPILRTRIVDLAGEGLVQTIIDEPFEWMTADDLDGYLRHDSQRTTGTGTPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7Q9</accession>
    <name>B8M7Q9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MHYT domain signaling protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_030540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480222.1">
        <property type="nucleotide sequence ID" value="XM_002480177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7Q9"/>
    <dbReference type="STRING" id="441959.B8M7Q9"/>
    <dbReference type="GeneID" id="8101733"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_030540"/>
    <dbReference type="eggNOG" id="ENOG502QTP5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008375_2_0_1"/>
    <dbReference type="InParanoid" id="B8M7Q9"/>
    <dbReference type="OMA" id="HERFEHI"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="PhylomeDB" id="B8M7Q9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005330">
        <property type="entry name" value="MHYT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152:SF1">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03707">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="MHYT" evidence="2">
        <location>
            <begin position="116"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="864" mass="95381" checksum="FE48957D14FB310F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B8M870</accession>
    <name>B8M870_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">TATA-binding protein-associated factor mot1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Modifier of transcription 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NCT transcriptional regulatory complex subunit mot1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TSTA_032850</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box via its C-terminal ATPase activity. Both transcription activation and repression require its ATPase activity. Part of the NCT transcriptional regulatory complex that acts as a key regulator of ergosterol biosynthesis and the azole exporter cdr1B. The NCT complex binds the promoters of genes linked to azole susceptibility, and especially represses the expression of cdr1B transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms the NCT transcriptional regulatory complex with nctA and nctB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480466.1">
        <property type="nucleotide sequence ID" value="XM_002480421.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B8M870">
        <property type="interactions" value="1353"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M870"/>
    <dbReference type="GeneID" id="8105024"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_032850"/>
    <dbReference type="eggNOG" id="KOG0392">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_1_1_1"/>
    <dbReference type="InParanoid" id="B8M870"/>
    <dbReference type="OMA" id="WYSDIAC"/>
    <dbReference type="OrthoDB" id="10252227at2759"/>
    <dbReference type="PhylomeDB" id="B8M870"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045898">
        <property type="term" value="P:regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17999">
        <property type="entry name" value="DEXHc_Mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000009">
        <property type="entry name" value="B-TFIID TATA-box-binding protein-associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000508">
        <property type="entry name" value="Probable helicase mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000445">
        <property type="entry name" value="Related to MOT1-transcriptional accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000428">
        <property type="entry name" value="TATA-binding protein-associated factor 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044972">
        <property type="entry name" value="Mot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044078">
        <property type="entry name" value="Mot1_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022707">
        <property type="entry name" value="Mot1_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498:SF1">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12054">
        <property type="entry name" value="DUF3535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="20" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="1313"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="1660"/>
            <end position="1811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="77"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="179"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="243"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="697"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="697"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EED20032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1894" mass="211103" checksum="2B2603B9D8F26E12" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8M901</accession>
    <name>B8M901_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_111390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481288.1">
        <property type="nucleotide sequence ID" value="XM_002481243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M901"/>
    <dbReference type="STRING" id="441959.B8M901"/>
    <dbReference type="ESTHER" id="talsn-b8m901">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="8109819"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_111390"/>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_16_4_1"/>
    <dbReference type="InParanoid" id="B8M901"/>
    <dbReference type="OMA" id="NGGILTW"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="PhylomeDB" id="B8M901"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012384141" description="Carboxylic ester hydrolase" evidence="4">
        <location>
            <begin position="16"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="17"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED17296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="569" mass="60818" checksum="DD15E778B13C2440" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9I1</accession>
    <name>B8M9I1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nitrogen metabolite repression regulator NmrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_115390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481733.1">
        <property type="nucleotide sequence ID" value="XM_002481688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9I1"/>
    <dbReference type="STRING" id="441959.B8M9I1"/>
    <dbReference type="GeneID" id="8101349"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_115390"/>
    <dbReference type="eggNOG" id="ENOG502QTW1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027360_0_0_1"/>
    <dbReference type="InParanoid" id="B8M9I1"/>
    <dbReference type="OMA" id="LWEGWRD"/>
    <dbReference type="OrthoDB" id="5356836at2759"/>
    <dbReference type="PhylomeDB" id="B8M9I1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF5">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="6"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED17741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="352" mass="38697" checksum="C08966A923C146D7" modified="2009-03-03" version="1">MTQVHKTIAVVNATGRQAASLIRVASALGYGVRAHTHTLKGVIAEELSSLPNVTLIKGDLLNNTALMDEIFKGAQLAFINTVSQAGDEVVIGRALADAAKRAGTIQHYIYSSMPDHSVHGPWPGPPMWACKFTVENYVRQLGIPATFVYAGIYNNNFTSLPYPLFQMELQPDGSFEWAAPFNPDVPLPWLDAEHDVGPALIQIFKDGPKRWNGHRIALTFETLSPIQVCAAFGRALGRRVRYRRTSKIEIKVKIPEGYREQLEVLEVLFGQLEAPYFPQPEFNTPAAGSPKGLGPAGGKGAGAGMMQGPGGVVSQRVTDEARKLWQGWRDMEEYAREVFPVEEEANGLQWML</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MA02</accession>
    <name>B8MA02_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_119180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482146.1">
        <property type="nucleotide sequence ID" value="XM_002482101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MA02"/>
    <dbReference type="GeneID" id="8104368"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119180"/>
    <dbReference type="eggNOG" id="ENOG502SRDU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049367_0_0_1"/>
    <dbReference type="InParanoid" id="B8MA02"/>
    <dbReference type="OMA" id="QEWDECA"/>
    <dbReference type="OrthoDB" id="5334491at2759"/>
    <dbReference type="PhylomeDB" id="B8MA02"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="207"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED18154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="302" mass="34064" checksum="2476F2541FECC540" modified="2009-03-03" version="1">MLMQSALSCDTRKFLGQQYYRTLSPTPPPSSDSISGSLLGVSRKLQNLLNVSPGATPSTPPRSVRLASPFHQEMKANKSKPKTRSRKTTPKTTPKPSTPRAITPTVSRAQTPTAPPRTRKRSRSVYEDGESETEIEMAGPRRLRDEYTTPKRLRHFPYHMPRGLGIADFESLNGHSAEQNTSHQETESEALPQIILPSIEIEDTEVSNTNDKADWTAEEDEQLVDMVLEKFRLTKRDWQECARRIGKDDASVGKRWQALLGEGNIGLRRGSGQFVRGRLDGYQEIVYNWKDTLGKRCLEEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MA52</accession>
    <name>B8MA52_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chromosome segregation in meiosis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_121250</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Forms a fork protection complex (FPC) with TOF1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Plays an important role in the control of DNA replication and the maintenance of replication fork stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the fork protection complex (FPC) consisting of TOF1 and CSM3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CSM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482373.1">
        <property type="nucleotide sequence ID" value="XM_002482328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MA52"/>
    <dbReference type="STRING" id="441959.B8MA52"/>
    <dbReference type="GeneID" id="8099365"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_121250"/>
    <dbReference type="eggNOG" id="KOG3004">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036204_1_0_1"/>
    <dbReference type="InParanoid" id="B8MA52"/>
    <dbReference type="OMA" id="GHEWADL"/>
    <dbReference type="OrthoDB" id="437078at2759"/>
    <dbReference type="PhylomeDB" id="B8MA52"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012923">
        <property type="entry name" value="Csm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040038">
        <property type="entry name" value="TIPIN/Csm3/Swi3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220">
        <property type="entry name" value="TIMELESS INTERACTING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220:SF11">
        <property type="entry name" value="TIMELESS-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07962">
        <property type="entry name" value="Swi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation in meiosis protein 3" evidence="11">
        <location>
            <begin position="63"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="150"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED18381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="295" mass="32791" checksum="5A7FA72EDE0D7289" modified="2009-03-03" version="1">MSDIDDLFDYDAGLDDILKNLPSAQNKETSQTEKGNNDEPDATKVLGLDADLKVTKQRVPIAKLDEARLLSQKGIPKLRKDVKTKLKFKGKAHEFSDLGRLLNFYQLWLDDLYPRAKFADGLAMIEKLGHSKRIQIMRREWINEEKPDYLRNADDEDHNNHDNSNPVAERDEAPGAQTATNNDTSADANVPLDDDMEDLFGEAPRRRSTPKQDTSSGSNDDVPPDDDLGMMLAEAENVNGTTEQDTFNESNTQAPVTDANNDNDAPPDDDLDMLLAEAENIAQAGDGSRKSIFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAN2</accession>
    <name>B8MAN2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenosine 5'-monophosphoramidase HNT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Histidine triad nucleotide-binding protein HNT1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_112870</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine 5'-phosphoramidate + H2O = NH4(+) + AMP</text>
            <dbReference type="Rhea" id="RHEA:67916"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57890"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:67917"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HINT family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481448.1">
        <property type="nucleotide sequence ID" value="XM_002481403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAN2"/>
    <dbReference type="FunCoup" id="B8MAN2">
        <property type="interactions" value="608"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MAN2"/>
    <dbReference type="GeneID" id="8105752"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_112870"/>
    <dbReference type="eggNOG" id="KOG3275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_3_0_1"/>
    <dbReference type="InParanoid" id="B8MAN2"/>
    <dbReference type="OMA" id="YRVVMNC"/>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="PhylomeDB" id="B8MAN2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043530">
        <property type="term" value="F:adenosine 5'-monophosphoramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000013">
        <property type="entry name" value="Hit family protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="12">
        <location>
            <begin position="7"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="10 11">
        <location>
            <begin position="95"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="9">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED17456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="135" mass="14940" checksum="2E5C1551E06E4E5E" modified="2009-03-03" version="1">MTSPACIFCKIIKGDIPSFKLFESDKVFAFLDIQPLSRGHALVIPKFHGAKLTDIPDEYLTELLPVAKKIAQATGAEDFNVLQNNGRAAHQLVDHVHFHVIPKPNEKEGLGISWPAQATDMDKLKALLEELKGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8MB25</accession>
    <name>B8MB25_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_124490</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ZNF598/HEL2 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482718.1">
        <property type="nucleotide sequence ID" value="XM_002482673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MB25"/>
    <dbReference type="FunCoup" id="B8MB25">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MB25"/>
    <dbReference type="GeneID" id="8098400"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_124490"/>
    <dbReference type="eggNOG" id="KOG2231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008515_1_0_1"/>
    <dbReference type="InParanoid" id="B8MB25"/>
    <dbReference type="OMA" id="VFTHEHT"/>
    <dbReference type="OrthoDB" id="3838338at2759"/>
    <dbReference type="PhylomeDB" id="B8MB25"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16615">
        <property type="entry name" value="RING-HC_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057634">
        <property type="entry name" value="PAH_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041888">
        <property type="entry name" value="RING-HC_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056437">
        <property type="entry name" value="Znf-C2H2_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23202">
        <property type="entry name" value="PAH_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25447">
        <property type="entry name" value="RING_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23230">
        <property type="entry name" value="zf-C2H2_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="134"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="400"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="459"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="676"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="708"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="416"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="459"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="722"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED18726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="759" mass="84006" checksum="F47547A7CA433320" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBB2</accession>
    <name>B8MBB2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor (AflR), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_126110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482893.1">
        <property type="nucleotide sequence ID" value="XM_002482848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBB2"/>
    <dbReference type="STRING" id="441959.B8MBB2"/>
    <dbReference type="GeneID" id="8098123"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_126110"/>
    <dbReference type="HOGENOM" id="CLU_031656_1_0_1"/>
    <dbReference type="InParanoid" id="B8MBB2"/>
    <dbReference type="OMA" id="VRCTKER"/>
    <dbReference type="OrthoDB" id="4226590at2759"/>
    <dbReference type="PhylomeDB" id="B8MBB2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045122">
        <property type="term" value="P:aflatoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013700">
        <property type="entry name" value="AflR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF31">
        <property type="entry name" value="MONODICTYPHENONE CLUSTER TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08493">
        <property type="entry name" value="AflR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED18901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="465" mass="51374" checksum="09F072E0A1217B1F" modified="2009-03-03" version="1">MQESTSSSQIPRTPLYTNEPVRRKPRSTTSKIRDSCHSCAISKVRCPKEKPTCARCMKRGVVCEYFVTKRPGRKRDNHVTEATETCHQISPPNSLLQDESGTGLFSSEPSSMAILNSSSTARELSNVSGTVEFSSYINVLADFMPPMEQSSPPRIPRVSNNFDGNLTPPIDFLKFGLLDSNMTNFAPESYDIEGLLTSSNFETGPSFENPLIGCTLPSKSFFALPVDQQGLLSNHDENSNTGVLDIMSKLFIPETPSSASMSTSPSDAATISNNTTSHSAVHSSAQAIVTQNKYFIESVDGILQCSLCAKTGYLMAILSTIISKILERYTIAARQDTRHSISEEYGSSERNGRKNTTTKEYAEHFGAYPGMHYNDARRSRAQLVLSELHRVQGLMNRLCKNALKEEAAQNNTDFERNSPRLSFSDGQRNGSEITFSAATLREMKSDLRKNLSSLSFGIIKMLRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBG6</accession>
    <name>B8MBG6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">endo-1,3(4)-beta-glucanase</fullName>
            <ecNumber evidence="4">3.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_116200</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;3)- or (1-&gt;4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.</text>
            <dbReference type="EC" id="3.2.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.6" evidence="4"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481822.1">
        <property type="nucleotide sequence ID" value="XM_002481777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBG6"/>
    <dbReference type="STRING" id="441959.B8MBG6"/>
    <dbReference type="GeneID" id="8099647"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_116200"/>
    <dbReference type="eggNOG" id="ENOG502QUM3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016972_1_0_1"/>
    <dbReference type="InParanoid" id="B8MBG6"/>
    <dbReference type="OMA" id="TEAYWEF"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="PhylomeDB" id="B8MBG6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000114">
        <property type="entry name" value="Probable endo-1,3(4)-beta-glucanase NFIA_089530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF42">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02280)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="12">
        <location>
            <begin position="76"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="446"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="446"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED17830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="503" mass="55710" checksum="041C6C5D265B221F" modified="2009-03-03" version="1">MAYQAHGQTQYPKSHGDTAPPYADNIALNSSINNDSPQKLSQYSRFDPRGWRTRTRLIAAGGIVVIIIAIIVGAYEGWKANRYPNYSALTYSLKDTYEGENFFDNFWYWSDADPTGGFVFYLQRANAVWSNLTYATKDSAVIKVDTSYPNTIGGRNSVRIQSNNTYNNGLFIFDILHTPYGCGTWPALWLADSSNWPTNGEIDVIEATNNGTWGNSMTLHTTDGCSMGVKRKETGKVTSKNCYNGTNSNEGCGVSSTTASYGPEFNKNGGGVYATELRDAGIRIWWWPRNSIPSDIADGKPDPSTWGEATADFPSTDCSISSHFRNQSIIANIDLCGSLAAADRYYIDQAQCPSNCTAYVAANPGAFAEAYWEFKSFKNYLQEANTWGSSYATDPYGTNTYGTSTYGGTSYSTYGDTTGGGANRTTYDPTTGAYDQHIDYDADATTRRHHREQMDESGRYYHRDVDRDTTGLDNTTRVHKEYSNPNTGTSYTRDSAYDRNNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBJ7</accession>
    <name>B8MBJ7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_116510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481853.1">
        <property type="nucleotide sequence ID" value="XM_002481808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBJ7"/>
    <dbReference type="GeneID" id="8102043"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_116510"/>
    <dbReference type="eggNOG" id="ENOG502QU1D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_842434_0_0_1"/>
    <dbReference type="InParanoid" id="B8MBJ7"/>
    <dbReference type="OMA" id="PGKGVCY"/>
    <dbReference type="OrthoDB" id="5426798at2759"/>
    <dbReference type="PhylomeDB" id="B8MBJ7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF11">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="281"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="85"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED17861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="330" mass="36315" checksum="3F55EABFF52B445F" modified="2009-03-03" version="1">MSITYSRIEHPGHTFPLQSMSYHYDGGRHGQDRNSRHYRLPPPHSSIPIGLIADEQQTSSHQRTDAQHSRNDFPAQRENLPSVHQLLSGGNAGYLPSLPPPTSRHGHSLQNSPSIHSLPPSSHYKPPRKSHGGYPDYSSLATSGDREYEDNRSPQSGTLPPISQVGMEASYTRPSHRSRSHLVSDEDSSRSQSKDATASPRHSDPSLSHFVSSPGQEGSRPGSRGPAVPNQVVDERYLPGKGVCYIFADNSYCPKLIDGQPVNPNWGLTKAGKARKRLAQACIPCREKKVKCQPNLPKCDQCQKSGRECRFESAPRGSRARSSSYDPQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBV3</accession>
    <name>B8MBV3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Sexual development transcription factor SteA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_119920</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the STE12 transcription factor family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482228.1">
        <property type="nucleotide sequence ID" value="XM_002482183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBV3"/>
    <dbReference type="STRING" id="441959.B8MBV3"/>
    <dbReference type="GeneID" id="8105266"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119920"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025505_0_0_1"/>
    <dbReference type="InParanoid" id="B8MBV3"/>
    <dbReference type="OMA" id="EMSRHGT"/>
    <dbReference type="OrthoDB" id="1095242at2759"/>
    <dbReference type="PhylomeDB" id="B8MBV3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990526">
        <property type="term" value="C:Ste12p-Dig1p-Dig2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990527">
        <property type="term" value="C:Tec1p-Ste12p-Dig1p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000243">
        <property type="entry name" value="Probable transcription factor steA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000390">
        <property type="entry name" value="Transcription factor stea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003120">
        <property type="entry name" value="Ste12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052127">
        <property type="entry name" value="STE12_transcription_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427:SF1">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02200">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00424">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="560"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="590"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="414"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="605"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="633"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="437"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="633"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED18236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="692" mass="77279" checksum="170B00F9C88BBE16" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBX0</accession>
    <name>B8MBX0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Inosine triphosphate pyrophosphatase</fullName>
            <shortName evidence="13">ITPase</shortName>
            <shortName evidence="13">Inosine triphosphatase</shortName>
            <ecNumber evidence="13">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="13">NTPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">XTP/dITP diphosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_121590</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ITP + H2O = IMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:29400"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-hydroxy-dATP + H2O = N(6)-hydroxy-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:83971"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:233529"/>
            <dbReference type="ChEBI" id="CHEBI:233530"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:83972"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>XTP + H2O = XMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:28343"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13 14">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="13"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482408.1">
        <property type="nucleotide sequence ID" value="XM_002482363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBX0"/>
    <dbReference type="FunCoup" id="B8MBX0">
        <property type="interactions" value="733"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MBX0"/>
    <dbReference type="GeneID" id="8098148"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_121590"/>
    <dbReference type="eggNOG" id="KOG3222">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082080_1_1_1"/>
    <dbReference type="InParanoid" id="B8MBX0"/>
    <dbReference type="OMA" id="YDPIFQP"/>
    <dbReference type="OrthoDB" id="6288734at2759"/>
    <dbReference type="PhylomeDB" id="B8MBX0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009204">
        <property type="term" value="P:deoxyribonucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.950.10:FF:000003">
        <property type="entry name" value="Inosine triphosphate pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03148">
        <property type="entry name" value="HAM1_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027502">
        <property type="entry name" value="ITPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00042">
        <property type="entry name" value="RdgB/HAM1 family non-canonical purine NTP pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="64"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="140"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="166"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED18416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="183" mass="20277" checksum="E0704D882D16AC36" modified="2009-03-03" version="1">MKTLNFITGNKNKLSEVRAILGDAVVVDNKSVDVPEIQGTIEEIAKEKCRRAADAVGGPVLTEDTALEFHAYKGLPGPYIKSFLEALGHEGLNKMLDSFDDRSAEAVCTFAFSNGPGEEPLIFQGRTLGKIVPARGPPNFGWDPIFEYEGKTYAEMDKEEKNKISHRYKALMKLKAWLIENEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBY5</accession>
    <name>B8MBY5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_121700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ELOF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482423.1">
        <property type="nucleotide sequence ID" value="XM_002482378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBY5"/>
    <dbReference type="FunCoup" id="B8MBY5">
        <property type="interactions" value="678"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MBY5"/>
    <dbReference type="GeneID" id="8098159"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_121700"/>
    <dbReference type="eggNOG" id="KOG3214">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105983_0_2_1"/>
    <dbReference type="InParanoid" id="B8MBY5"/>
    <dbReference type="OMA" id="CLDANKK"/>
    <dbReference type="OrthoDB" id="445983at2759"/>
    <dbReference type="PhylomeDB" id="B8MBY5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.190:FF:000001">
        <property type="entry name" value="Transcription elongation factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934:SF0">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Zn_ribbon_Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED18431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="117" mass="12543" checksum="4D2EFD83BA89BEF3" modified="2009-03-03" version="1">MGKRKKSSRGPQGPKKREPLATTFACLFCNHENSITVKLDKKLGVGNLSCKVCGQRFQTGINYLSAAVDVYSDWVDACDAVAKSKANTYDASGSQAVYSRGSAGPDADLEDPVHDDL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-24" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBY6</accession>
    <name>RS3A_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">40S ribosomal protein S1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">rps1</name>
        <name type="ORF">TSTA_121710</name>
    </gene>
    <organism>
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482424.1">
        <property type="nucleotide sequence ID" value="XM_002482379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBY6"/>
    <dbReference type="SMR" id="B8MBY6"/>
    <dbReference type="FunCoup" id="B8MBY6">
        <property type="interactions" value="1326"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MBY6"/>
    <dbReference type="GeneID" id="8098160"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_121710"/>
    <dbReference type="eggNOG" id="KOG1628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062507_0_0_1"/>
    <dbReference type="InParanoid" id="B8MBY6"/>
    <dbReference type="OMA" id="TRFKGHE"/>
    <dbReference type="OrthoDB" id="9834376at2759"/>
    <dbReference type="PhylomeDB" id="B8MBY6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_eS1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000389414" description="Small ribosomal subunit protein eS1">
        <location>
            <begin position="2"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="modified residue" description="N-acetylalanine; partial" evidence="1">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="256" mass="29184" checksum="BC684F0C5DBB04E3" modified="2009-03-03" version="1">MAVGKNKRLSKGKKGLKKRTVDPFSRKDEYSVKAPSTFQIRDVGKTLVNRTTGLKNANDSLKGRIFEVSLADLQNDEDHAFRKVKLRVDEVQGKNCLTNFHGLDFTSDKLRSLVRKWQSLIEANVTVKTTDDYLLRLFAIAFTKRRPNQIKKTTYARSSQIRAIRKKMTEIIQREAASCTLSQLTTKLIPEVIGREIEKSTQGIYPLQNVHIRKVKLLKSPKFDLGALLNLHGESTTDDQGHKVEREFKETVLESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MC17</accession>
    <name>B8MC17_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_121990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482455.1">
        <property type="nucleotide sequence ID" value="XM_002482410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MC17"/>
    <dbReference type="FunCoup" id="B8MC17">
        <property type="interactions" value="351"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MC17"/>
    <dbReference type="GeneID" id="8105485"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_121990"/>
    <dbReference type="eggNOG" id="KOG1505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041844_3_2_1"/>
    <dbReference type="InParanoid" id="B8MC17"/>
    <dbReference type="OMA" id="RMVMIAN"/>
    <dbReference type="OrthoDB" id="189226at2759"/>
    <dbReference type="PhylomeDB" id="B8MC17"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="5">
        <location>
            <begin position="131"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED18463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="410" mass="47390" checksum="473A2E3D368CDBBA" modified="2009-03-03" version="1">MSDIRRRVPIDPSGTSVVSEEPQVSDKEKNAGLKHGVFMQIFRSLLLITWFNCCCVCIVATQLIGAPLYLVNKDYYYAYMAMTKQCFGILMITITQWGAPTVVRVSGDDSVNGQIQMTANGLLKTNFPDRLVFIANHQVYTDWTYLWWVGYTSRMHGHIYIILKESLKYLPVLGQGMMFYGFIFMARKWEADKPRLEHRLQKLKTRHSGPMSGPQSLDPMWLLIFPEGTNLSINTKNVSNRYGEKMGIEPLKHMILPRSTGLLFCLQQLRGTVDYVYDCTVGYEGPPKGVYPDRFYTLRSIYGQGRPPKSVNMYWRRWSLAEIPLDDPKAFEQWLLERWREKDALLDQFFETGRFPTSLGSSIETQHIPDKQKEEASRGYVETEIQLARWIEIAEIFVVLLLVGFLCRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>B8MC90</accession>
    <name>B8MC90_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_122680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482528.1">
        <property type="nucleotide sequence ID" value="XM_002482483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MC90"/>
    <dbReference type="STRING" id="441959.B8MC90"/>
    <dbReference type="GeneID" id="8097733"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_122680"/>
    <dbReference type="eggNOG" id="ENOG502RF8N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015502_2_0_1"/>
    <dbReference type="InParanoid" id="B8MC90"/>
    <dbReference type="OMA" id="IDDLCGW"/>
    <dbReference type="OrthoDB" id="2399539at2759"/>
    <dbReference type="PhylomeDB" id="B8MC90"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="542"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED18536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="606" mass="67773" checksum="2EECA17AFC7F19B9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCC0</accession>
    <name>B8MCC0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_122950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482558.1">
        <property type="nucleotide sequence ID" value="XM_002482513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCC0"/>
    <dbReference type="GeneID" id="8097760"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_122950"/>
    <dbReference type="HOGENOM" id="CLU_1349700_0_0_1"/>
    <dbReference type="InParanoid" id="B8MCC0"/>
    <dbReference type="OrthoDB" id="10632174at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED18566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="203" mass="23202" checksum="0CB44A8EC6E530A0" modified="2009-03-03" version="1">MFKTSANPSGSYLPFFDLYIKDINQKQPLKLDEGLPKRMWLMMGTLGSKPQCPSQKTKIVEGGMSGHLMNFNPKNAGPLHEFLRPRGGNNGNNEIQRYAQPLAVAKDAYQMVLCPFNLEPGKWEYEMVGEFNFTYKDGEGESEGNMRMEIDITFWFEVEKNGENARKTLKILEMKPPQIAYYAEKEGRLMPVYVSDPVEERSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCC8</accession>
    <name>B8MCC8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Phosphoglucomutase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_123040</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482566.1">
        <property type="nucleotide sequence ID" value="XM_002482521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCC8"/>
    <dbReference type="FunCoup" id="B8MCC8">
        <property type="interactions" value="325"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MCC8"/>
    <dbReference type="GeneID" id="8108219"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_123040"/>
    <dbReference type="eggNOG" id="KOG1220">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_0_1_1"/>
    <dbReference type="InParanoid" id="B8MCC8"/>
    <dbReference type="OMA" id="GYCVDPE"/>
    <dbReference type="OrthoDB" id="8300170at2759"/>
    <dbReference type="PhylomeDB" id="B8MCC8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008973">
        <property type="term" value="F:phosphopentomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046115">
        <property type="term" value="P:guanosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006148">
        <property type="term" value="P:inosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05799">
        <property type="entry name" value="PGM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000035">
        <property type="entry name" value="Pgm3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745:SF1">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745">
        <property type="entry name" value="PHOSPHOMANNOMUTASE 45A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="11">
        <location>
            <begin position="48"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="12">
        <location>
            <begin position="215"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="13">
        <location>
            <begin position="331"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED18574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="610" mass="68564" checksum="F1A501FFAF9D59CD" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCE1</accession>
    <name>B8MCE1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="3">FBP aldolase</shortName>
            <ecNumber evidence="3">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_124760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2 3">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="3"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482749.1">
        <property type="nucleotide sequence ID" value="XM_002482704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCE1"/>
    <dbReference type="STRING" id="441959.B8MCE1"/>
    <dbReference type="GeneID" id="8100255"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_124760"/>
    <dbReference type="eggNOG" id="KOG4153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040088_4_0_1"/>
    <dbReference type="InParanoid" id="B8MCE1"/>
    <dbReference type="OMA" id="TCYSAIR"/>
    <dbReference type="OrthoDB" id="2558351at2759"/>
    <dbReference type="PhylomeDB" id="B8MCE1"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050246">
        <property type="entry name" value="Class_II_FBP_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30304">
        <property type="entry name" value="D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30304:SF0">
        <property type="entry name" value="D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE SUBUNIT GATY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED18757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="288" mass="31196" checksum="74430A2FC7C419BA" modified="2009-03-03" version="1">MPHPNLKGNRALEILDKALAGKYGVPGMCCYNIEGILATVRAAEAKKSPAMILLFPWAIQYADGLLVHAAAEAAKKAKVPVTVHMDHAQSPEIIRYAADLGGFDSIMVDMSHYEKEENLAKTRELVAYCHERGIATEAEPGRIEGGEDGVADTADLTGLLTTPEESHEFVATGIDWLAPAFGNVHGSYGPRGVQLEYDRLESINKAVGDKVRIVLHGADPFTTEIFQKCISHGVSKININKVMNNEYLRVQAEKAGKVPLTTLHEEVTNAMQAAVERCMDMLGSTGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCN1</accession>
    <name>B8MCN1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_126410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002482880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCN1"/>
    <dbReference type="STRING" id="441959.B8MCN1"/>
    <dbReference type="GeneID" id="8099068"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_126410"/>
    <dbReference type="eggNOG" id="ENOG502RZYI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059042_3_0_1"/>
    <dbReference type="InParanoid" id="B8MCN1"/>
    <dbReference type="OMA" id="STHDITM"/>
    <dbReference type="OrthoDB" id="5289248at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="66"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED18933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="215" mass="24569" checksum="CFD6735F3B56ECE9" modified="2009-03-03" version="1">MSNTALLFGRSATYISVVLKLNLRYLAVRYNHILDWHPTLTYERMATYASSLEKVSKGAIRIWGFIDGTFREICRPIRDQKIFYNGYEGAHGIKYQGTVAPDGLILSLHGPFPGSTHDITMYQSCGLPEKLREIMKQREQLFLYGDIAYTSSFRIITPYKVTRPLTRKEKRLIKVLSSDRIGIENAFGKVVTQFATTQFKPDQPVNKPSCFSKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCZ8</accession>
    <name>B8MCZ8_TALSN</name>
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        <submittedName>
            <fullName evidence="15">DsDNA-dependent ATPase Rad54, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_113500</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481516.1">
        <property type="nucleotide sequence ID" value="XM_002481471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCZ8"/>
    <dbReference type="FunCoup" id="B8MCZ8">
        <property type="interactions" value="570"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MCZ8"/>
    <dbReference type="GeneID" id="8101662"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_113500"/>
    <dbReference type="eggNOG" id="KOG0390">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_10_2_1"/>
    <dbReference type="InParanoid" id="B8MCZ8"/>
    <dbReference type="OMA" id="YTEHERM"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="PhylomeDB" id="B8MCZ8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000332">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013967">
        <property type="entry name" value="Rad54_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08658">
        <property type="entry name" value="Rad54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="232"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="565"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED17524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="808" mass="91522" checksum="050D907A9149F016" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8MD00</accession>
    <name>B8MD00_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_113520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED17526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481518.1">
        <property type="nucleotide sequence ID" value="XM_002481473.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481519.1">
        <property type="nucleotide sequence ID" value="XM_002481474.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481520.1">
        <property type="nucleotide sequence ID" value="XM_002481475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MD00"/>
    <dbReference type="GeneID" id="8101664"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_113520"/>
    <dbReference type="eggNOG" id="ENOG502RNSK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034488_0_0_1"/>
    <dbReference type="InParanoid" id="B8MD00"/>
    <dbReference type="OMA" id="VMASHHK"/>
    <dbReference type="OrthoDB" id="4360110at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED17526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="585" mass="65258" checksum="FEF74B97F7324449" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MD59</accession>
    <name>B8MD59_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Clock controlled protein (Ccg-8), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_113990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
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</entry>
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        <location>
            <begin position="37"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="609" mass="67931" checksum="8B978FACF0BE5B40" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDK8</accession>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Trichocomaceae</taxon>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062853_1_0_1"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
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        <property type="entry name" value="54S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL1M"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
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    </dbReference>
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            <end position="66"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED17971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="306" mass="33915" checksum="AB6084DE1110F0BB" modified="2009-03-03" version="1">MAYAFRALPVTAGHISASCRSTLRQNSAIAPFLYPLGQQQVRTATSNPQAKGKKNKQKESKKKVKGARDYQQKDLSLIDQYALCDAMRYIRAFEVGRDRERSKYEIHIRLKSRKDGPVIRNMVRFPHAVQTESRICVIAPPGSKHAKDALEAGASIVGEQEVFENIKKGIIEFERCICHTDSLDALNKAGLGRILGPRGLMPSVKTGTVVDDVGIRVQMLRGGTVYRERDAVIRMPIGQLGFSPDQLRDNLRAALEQVKKDTTQLSDRVPKEVYEVVLSSTNGPGFSLNGDFRSDSSPEPAYLTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEJ9</accession>
    <name>B8MEJ9_TALSN</name>
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        <recommendedName>
            <fullName evidence="4">Chitinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_017010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEJ9"/>
    <dbReference type="STRING" id="441959.B8MEJ9"/>
    <dbReference type="GeneID" id="8103674"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_017010"/>
    <dbReference type="HOGENOM" id="CLU_2607634_0_0_1"/>
    <dbReference type="InParanoid" id="B8MEJ9"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="PhylomeDB" id="B8MEJ9"/>
    <dbReference type="Proteomes" id="UP000001745">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002875101" description="Chitinase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="8524" checksum="4205946032635ABF" modified="2009-03-03" version="1">MKYLALTGFLAAHAAALRNVMYVDHLPSSDLVSSVTYAIMAFAPSENFNSGSTFTPFESINTFRARFPSTTKIMVAIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MET9</accession>
    <name>B8MET9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA binding protein MSSP-2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_020310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="441959.B8MET9"/>
    <dbReference type="GeneID" id="8109986"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_020310"/>
    <dbReference type="eggNOG" id="KOG4733">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031131_0_0_1"/>
    <dbReference type="InParanoid" id="B8MET9"/>
    <dbReference type="OMA" id="RAIPAMW"/>
    <dbReference type="OrthoDB" id="271725at2759"/>
    <dbReference type="PhylomeDB" id="B8MET9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000323">
        <property type="entry name" value="RNA binding protein MSSP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="240"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="328"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="16"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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            <end position="455"/>
        </location>
    </feature>
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        <location>
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            <end position="524"/>
        </location>
    </feature>
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        <location>
            <begin position="541"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="436"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="499"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED16972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="577" mass="63265" checksum="5F9E79CDD90F0895" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFB4</accession>
    <name>B8MFB4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_017230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483882.1">
        <property type="nucleotide sequence ID" value="XM_002483837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFB4"/>
    <dbReference type="GeneID" id="8103696"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_017230"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090753_0_0_1"/>
    <dbReference type="InParanoid" id="B8MFB4"/>
    <dbReference type="OMA" id="MKTGVRP"/>
    <dbReference type="OrthoDB" id="4526357at2759"/>
    <dbReference type="PhylomeDB" id="B8MFB4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED16648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="191" mass="20715" checksum="550B99A7BD1B0A90" modified="2009-03-03" version="1">MEAYAIYSSLRSQLNSNSAALKEVQTTKTGFALCPSSPEALLALEAQKEIISAFFVNCQIERSSRWVSYRVTNVPRKIGQILNGQYSLIPVNPTLLSSEISETTGLKPTSISETTSSAVNPDTPSSSWFLFNAHDAGNGIMQDPVPAPLDAGYVAPQSILKRAMPIAAQPWNLINALLDAYTVMDHIQLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFP3</accession>
    <name>B8MFP3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">cAMP receptor-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_020910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484267.1">
        <property type="nucleotide sequence ID" value="XM_002484222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFP3"/>
    <dbReference type="STRING" id="441959.B8MFP3"/>
    <dbReference type="GeneID" id="8109351"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_020910"/>
    <dbReference type="eggNOG" id="ENOG502QWAA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024810_3_1_1"/>
    <dbReference type="InParanoid" id="B8MFP3"/>
    <dbReference type="OMA" id="RMEIPYL"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="PhylomeDB" id="B8MFP3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05462">
        <property type="entry name" value="Dicty_CAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="11"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="415"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED17033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="459" mass="51514" checksum="C5B7D50E3861CE75" modified="2009-03-03" version="1">MSLSDQQLSAITAAERVTSILSVVGTTIVISTFLSSRAFRKPINRVVFFASWANILTNVGTFISRTAIAQREHGVALCWFQGFLIQWLMPADALWTLAMAFNVYLTFFHKYDAVKLRRLEWKYLVLCYGLPFIPPFIYFFIHSSSKGPVYGSATLWCWVSIEWDILRIAVFYGPVWFVILLTFAIYTRVGIDISRKRRMLRSFNKEASMMMDERLNNLFEIHASKVVHVTSEVVRDTSHSNDSNGSNSSSSNYNIDPNGNTNDNSHITAYPSYSVTIGRGDEFPLPPSAPSTVGSTSVKIAATPSRRTPRIDISSAAFAYCKYAMLYFVALIVTWVPSTINRVYSLFYPDQVVFGLQFVSALVLPLQGFWNSIIYIAVSWATVMDLIDRFSARFQRRSSLSSSNDATAGMKMNHSFPRKSSHLSPGAARNTGGQANRRVSDDAESTTYFAKDVEGRQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGF9</accession>
    <name>B8MGF9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_013790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483513.1">
        <property type="nucleotide sequence ID" value="XM_002483468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGF9"/>
    <dbReference type="STRING" id="441959.B8MGF9"/>
    <dbReference type="GeneID" id="8099178"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_013790"/>
    <dbReference type="eggNOG" id="KOG2216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143031_0_0_1"/>
    <dbReference type="InParanoid" id="B8MGF9"/>
    <dbReference type="OrthoDB" id="20582at2759"/>
    <dbReference type="PhylomeDB" id="B8MGF9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019163">
        <property type="entry name" value="THO_Thoc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375">
        <property type="entry name" value="FMS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375:SF3">
        <property type="entry name" value="THO COMPLEX SUBUNIT 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09766">
        <property type="entry name" value="FmiP_Thoc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED16279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="155" mass="17594" checksum="4D4F2C65CB6AF31E" modified="2009-03-03" version="1">MAETACMTVRDIVTDPSLLPVLQVSANAHNECQKLLQLLDPNNAATTATIPSQETILAISRQQKILYALLAQLRGLNRDAILRVRETKQVTAQARQEIDRLHLQLQNLYYEQKHLMGEIAACESYDHIYRSLPLIPEEDFFNYSLNTQTQTPTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGW4</accession>
    <name>B8MGW4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trehalose-6-phosphate synthase</fullName>
            <ecNumber evidence="6">2.4.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">UDP-glucose-glucosephosphate glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_014360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="2.4.1.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.15" evidence="6"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483579.1">
        <property type="nucleotide sequence ID" value="XM_002483534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGW4"/>
    <dbReference type="FunCoup" id="B8MGW4">
        <property type="interactions" value="611"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MGW4"/>
    <dbReference type="GeneID" id="8107819"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_014360"/>
    <dbReference type="eggNOG" id="KOG1050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002351_7_2_1"/>
    <dbReference type="InParanoid" id="B8MGW4"/>
    <dbReference type="OMA" id="AFWIQDY"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="PhylomeDB" id="B8MGW4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000007">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000035">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012766">
        <property type="entry name" value="Trehalose_OtsA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02400">
        <property type="entry name" value="trehalose_OtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF106">
        <property type="entry name" value="BCDNA.GH08860"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED16345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="484" mass="54411" checksum="CB19B585470A1CB5" modified="2009-03-03" version="1">MSPAPAVAAPPESGRLLLVSNRLPITIRRSEGGKYEFSMSSGGLVTGLSGLAKTTTFQWYGWPGLEVPEDEIETVKSKLKEEYGATPVFIDDQLADRHYNGFSNSILWPLLHYHPGEIVFDESAWVAYKEANALFAQTIADEAKDGDMIWVHDYHLMLLPQLLRERLRAQGKKNIKIGFFLHTPFPSSEIYRVLPVRADLLKGVLYCDLIGFHTFDYARHFLSSCTHILNLSTTPGSVRFENRSVSVGAFPIGIDPEKFLDGLKNPKVQNRIASLESKFQGMKLMVSVDRLDYIKGIPQKLHALEVFLSNHPEWVGKVVLVQVAVPSRQDVEEYQNLRAVVNELVGRINGRFGTVDYMPIHFMHKSVNFEELLALYAVSDACVVSSTRDGMNLVSFEYIASQQKRQGVLILSEFAGAAQSLNGSLVVNPWNTEDLAKAYHQAVSMEPEQRAAKYQKLWKYISKYTSAFWGQSFVAELSRCTAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGW5</accession>
    <name>B8MGW5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha,alpha-trehalose phosphate synthase subunit, putative</fullName>
            <ecNumber evidence="6">2.4.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_014370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.15" evidence="6"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483580.1">
        <property type="nucleotide sequence ID" value="XM_002483535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGW5"/>
    <dbReference type="FunCoup" id="B8MGW5">
        <property type="interactions" value="319"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MGW5"/>
    <dbReference type="GeneID" id="8107820"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_014370"/>
    <dbReference type="eggNOG" id="KOG1050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002351_2_2_1"/>
    <dbReference type="InParanoid" id="B8MGW5"/>
    <dbReference type="OMA" id="SHDFIHC"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="PhylomeDB" id="B8MGW5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000099">
        <property type="entry name" value="Alpha,alpha-trehalose phosphate synthase subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000036">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF15">
        <property type="entry name" value="TREHALOSE SYNTHASE COMPLEX REGULATORY SUBUNIT TPS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="73"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED16346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="892" mass="99880" checksum="2CBE3053EE2E1FF9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHF9</accession>
    <name>B8MHF9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_021950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484372.1">
        <property type="nucleotide sequence ID" value="XM_002484327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHF9"/>
    <dbReference type="STRING" id="441959.B8MHF9"/>
    <dbReference type="GeneID" id="8098461"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_021950"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_1_1_1"/>
    <dbReference type="InParanoid" id="B8MHF9"/>
    <dbReference type="OMA" id="QIDFREQ"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="PhylomeDB" id="B8MHF9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051704">
        <property type="entry name" value="FAD_aromatic-hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865:SF2">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="4"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED17138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="401" mass="45096" checksum="01639B392D9FE416" modified="2009-03-03" version="1">MTSLKVLICGGGCAGPALAYWLSKCGHQVVVVERFPSLRASGAQIDLRAQGIEIVKRMGLLDVIRTKLVDEVGFSFVDSQGRVKATIMANKSGKGAQSLTSEFEIMRGDLVRVLYDATKDNVKYVFGKKVEYHEQDEQQVMVYFSDGSSDYFDLLVGADGQGSRIRQAILTPPNTNPYKRLGVHIAYYFVPRTQDDTDTSHMYHCAGGRVIMRRSHNQEQSQVYLFLRDGSEELQSLSKAPLEQQKEFWSQRFADAGWQAPRFLGDIKTTDNFYCQEVVQVRINSWYKGRVVLLGDAAHCASPFSGMGTTGGFVGAYVLAGEINRHRDDLAQAFANYEEKLRPFVNELQKMSPTGVRLFAPETQWAIRWLCILRIPDLLARISSDEKGGWKLPDYPELYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHG4</accession>
    <name>B8MHG4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reverse transcriptase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_022000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484377.1">
        <property type="nucleotide sequence ID" value="XM_002484332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHG4"/>
    <dbReference type="STRING" id="441959.B8MHG4"/>
    <dbReference type="GeneID" id="8098466"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_022000"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_26_3_1"/>
    <dbReference type="InParanoid" id="B8MHG4"/>
    <dbReference type="OMA" id="ITISCCE"/>
    <dbReference type="OrthoDB" id="4357294at2759"/>
    <dbReference type="PhylomeDB" id="B8MHG4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="3">
        <location>
            <begin position="531"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED17143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="833" mass="91765" checksum="9AD5A3EC34CE5F8D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MI30</accession>
    <name>B8MI30_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_022460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484426.1">
        <property type="nucleotide sequence ID" value="XM_002484381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MI30"/>
    <dbReference type="GeneID" id="8107083"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_022460"/>
    <dbReference type="eggNOG" id="ENOG502RA41">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055491_7_1_1"/>
    <dbReference type="InParanoid" id="B8MI30"/>
    <dbReference type="OMA" id="SITACNC"/>
    <dbReference type="OrthoDB" id="2993351at2759"/>
    <dbReference type="PhylomeDB" id="B8MI30"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="6"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED17192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="140" mass="16265" checksum="BC3DB645ED7ED711" modified="2009-03-03" version="1">MAHKSLKSTCHCGAITVIVPHQPEEINECQCTICRRYAAAWAYYKVNEIKFNMKEGAKLSQYVWGDKEKSFNFCENCGCICYWWPFEKKKADGSAADFGVNTRNMDPMEILHVNRKIENAWVFQPINNKTMAHEQDQAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIB0</accession>
    <name>B8MIB0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">TSTA_040740</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484547.1">
        <property type="nucleotide sequence ID" value="XM_002484502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIB0"/>
    <dbReference type="FunCoup" id="B8MIB0">
        <property type="interactions" value="164"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MIB0"/>
    <dbReference type="GeneID" id="8110031"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_040740"/>
    <dbReference type="eggNOG" id="KOG1027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004875_2_0_1"/>
    <dbReference type="InParanoid" id="B8MIB0"/>
    <dbReference type="OMA" id="QCYEKDY"/>
    <dbReference type="OrthoDB" id="63989at2759"/>
    <dbReference type="PhylomeDB" id="B8MIB0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09769">
        <property type="entry name" value="Luminal_IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10422">
        <property type="entry name" value="RNase_Ire1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13982">
        <property type="entry name" value="STKc_IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000572">
        <property type="entry name" value="Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000443">
        <property type="entry name" value="Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.180">
        <property type="entry name" value="KEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010513">
        <property type="entry name" value="KEN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038357">
        <property type="entry name" value="KEN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF6">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06479">
        <property type="entry name" value="Ribonuc_2-5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51392">
        <property type="entry name" value="KEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 25" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8 22" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="17" id="KW-0834">Unfolded protein response</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877519" description="non-specific serine/threonine protein kinase" evidence="22">
        <location>
            <begin position="33"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="743"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="domain" description="KEN" evidence="24">
        <location>
            <begin position="1048"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="485"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="584"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="937"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="584"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="628"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="671"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EED14594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1184" mass="132024" checksum="4EB6C793E5D6295F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIU5</accession>
    <name>B8MIU5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">12-oxophytodienoate reductase opr, putative</fullName>
            <ecNumber evidence="5">1.3.1.42</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_050460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.42" evidence="5"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485560.1">
        <property type="nucleotide sequence ID" value="XM_002485515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIU5"/>
    <dbReference type="STRING" id="441959.B8MIU5"/>
    <dbReference type="GeneID" id="8109088"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_050460"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_0_2_1"/>
    <dbReference type="InParanoid" id="B8MIU5"/>
    <dbReference type="OMA" id="APCTRMR"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="PhylomeDB" id="B8MIU5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016629">
        <property type="term" value="F:12-oxophytodienoate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000059">
        <property type="entry name" value="N-ethylmaleimide reductase, FMN-linked"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF129">
        <property type="entry name" value="FLAVIN OXIDOREDUCTASE HXNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="4">
        <location>
            <begin position="10"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED15607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="385" mass="41952" checksum="4340D5FCA9EF0876" modified="2009-03-03" version="1">MGSIDIVGPLFQPLRLGAVTLSHRVVQAPTTRMRSTKESDGVSVPNDLNVEYYTQRASPGGLMITEATPISRLAAGYPGVPGIFTPSQVAGWKKVTSAVHAKGAYIYCQLWHVGRATVPSFIEGKRALSATDVPISGKAMDGNEYATTPPRPMTVEEIQETVKEYAAASKRAIEAGFDGVEIHAGNGYLLDQFLHDNVNNRTDDYGGSIEKRSRIVLEVLQAAAEAIGAERVGIRLSPYNYFQDTRDSNPNVHWLWLCSQIAALPAKLRPAYVHMVEPRFDEVLDEDAKMVSLAGGKPSLDVFRPTLKKAGIAFLAAGNFNSQNAGPKLLEDGADAVAFGRLFIANPDLPRRLKEGLPLNQYDRSTFYGADPPEKGYTDYGFYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJ19</accession>
    <name>B8MJ19_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_051190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485634.1">
        <property type="nucleotide sequence ID" value="XM_002485589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJ19"/>
    <dbReference type="STRING" id="441959.B8MJ19"/>
    <dbReference type="GeneID" id="8106321"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_051190"/>
    <dbReference type="eggNOG" id="ENOG502QQEX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010060_1_1_1"/>
    <dbReference type="InParanoid" id="B8MJ19"/>
    <dbReference type="OMA" id="LVEYMEW"/>
    <dbReference type="OrthoDB" id="406864at2759"/>
    <dbReference type="PhylomeDB" id="B8MJ19"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055235">
        <property type="entry name" value="ASD1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051563">
        <property type="entry name" value="Glycosyl_Hydrolase_51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776:SF0">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877539" description="non-reducing end alpha-L-arabinofuranosidase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-arabinofuranosidase C-terminal" evidence="9">
        <location>
            <begin position="463"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED15681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="640" mass="70494" checksum="3592DE1C8ED1BCF7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJN4</accession>
    <name>B8MJN4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_051700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485686.1">
        <property type="nucleotide sequence ID" value="XM_002485641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJN4"/>
    <dbReference type="GeneID" id="8103391"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_051700"/>
    <dbReference type="HOGENOM" id="CLU_094692_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJN4"/>
    <dbReference type="OrthoDB" id="4230168at2759"/>
    <dbReference type="PhylomeDB" id="B8MJN4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877546" evidence="2">
        <location>
            <begin position="22"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED15733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="159" mass="17868" checksum="CE1F95A3DB4CA159" modified="2009-03-03" version="1">MVGKIVGFGLTILALLPTIKSISPPSSVQKLRRYVNKIEKSLDGIKDILDESSPGLIRRIKTVNQGSLIMADLGELHRENFTQIRDTAKRKAAKRTKRQVKAVGALYVKDANRLIKHRHDGDLMKIHKRYILGERQQGEEEEAPAPQTPGFFIDTTGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8MK01</accession>
    <name>B8MK01_TALSN</name>
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        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_042900</name>
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    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484771.1">
        <property type="nucleotide sequence ID" value="XM_002484726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MK01"/>
    <dbReference type="STRING" id="441959.B8MK01"/>
    <dbReference type="GeneID" id="8104767"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_042900"/>
    <dbReference type="eggNOG" id="ENOG502RF8N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_506391_0_0_1"/>
    <dbReference type="InParanoid" id="B8MK01"/>
    <dbReference type="OMA" id="FAYRITA"/>
    <dbReference type="OrthoDB" id="2399539at2759"/>
    <dbReference type="PhylomeDB" id="B8MK01"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="101"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED14818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="538" mass="60409" checksum="9B7745698ABC30CA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKD5</accession>
    <name>B8MKD5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit J</fullName>
            <shortName evidence="5">eIF3j</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 30 kDa subunit homolog</fullName>
            <shortName evidence="5">eIF-3 30 kDa subunit homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">HCR1</name>
        <name evidence="7" type="ORF">TSTA_047390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit J family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485243.1">
        <property type="nucleotide sequence ID" value="XM_002485198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKD5"/>
    <dbReference type="FunCoup" id="B8MKD5">
        <property type="interactions" value="118"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MKD5"/>
    <dbReference type="GeneID" id="8099289"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_047390"/>
    <dbReference type="eggNOG" id="KOG4813">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087988_0_0_1"/>
    <dbReference type="InParanoid" id="B8MKD5"/>
    <dbReference type="OMA" id="KPHYALW"/>
    <dbReference type="OrthoDB" id="20381at2759"/>
    <dbReference type="PhylomeDB" id="B8MKD5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.60:FF:000003">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.60">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03009">
        <property type="entry name" value="eIF3j"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023194">
        <property type="entry name" value="eIF3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013906">
        <property type="entry name" value="eIF3j"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08597">
        <property type="entry name" value="eIF3_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED15290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="270" mass="29957" checksum="C55D22E28B6FEFD5" modified="2009-03-03" version="1">MAPSKWDDEEESTPPSSPPPVAGRRKFDDEEDDEVLDSWDAAEDSEVEREKAAAAAAAKAKAEAEAAAKKKSKAQRIQEHQQERKKLEEEEEDSDDDSSEDEAERRARLRKTEKDSDLKHAEDLFGDIDLNRNRGKSKAIVVGDASDPTKAIDLSAMPLFKPTTKDQFANLTNVLIPLLTANSKKPQYALWAPEFAKQLVKDLPSDQVKKVASALTTLSNEKMREERAADKGSKKSKAAKTKTSLNTARDFAKVDTNAYDDDDLGDDDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLN3</accession>
    <name>B8MLN3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pre-mRNA splicing factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_101360</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486134.1">
        <property type="nucleotide sequence ID" value="XM_002486089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLN3"/>
    <dbReference type="STRING" id="441959.B8MLN3"/>
    <dbReference type="GeneID" id="8101824"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_101360"/>
    <dbReference type="eggNOG" id="KOG0007">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013259_3_1_1"/>
    <dbReference type="InParanoid" id="B8MLN3"/>
    <dbReference type="OMA" id="VKYQEQQ"/>
    <dbReference type="OrthoDB" id="447637at2759"/>
    <dbReference type="PhylomeDB" id="B8MLN3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000015">
        <property type="entry name" value="Splicing factor 3A subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000001">
        <property type="entry name" value="Splicing factor 3a, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045146">
        <property type="entry name" value="SF3A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022030">
        <property type="entry name" value="SF3A1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316">
        <property type="entry name" value="SPLICEOSOME ASSOCIATED PROTEIN 114/SWAP SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316:SF1">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12230">
        <property type="entry name" value="PRP21_like_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SURP motif" evidence="9">
        <location>
            <begin position="37"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="9">
        <location>
            <begin position="136"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="473"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="544"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="194"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="544"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="595"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED13896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="606" mass="67709" checksum="E891C4FB2BDF625A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MM04</accession>
    <name>B8MM04_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD dependent epimerase/dehydratase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_097720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485754.1">
        <property type="nucleotide sequence ID" value="XM_002485709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MM04"/>
    <dbReference type="STRING" id="441959.B8MM04"/>
    <dbReference type="GeneID" id="8108411"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_097720"/>
    <dbReference type="eggNOG" id="ENOG502SKH5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_8_4_1"/>
    <dbReference type="InParanoid" id="B8MM04"/>
    <dbReference type="OMA" id="VEPFVRM"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="PhylomeDB" id="B8MM04"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF30">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="76"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED13516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="380" mass="41773" checksum="4203FFB343D25DCB" modified="2009-03-03" version="1">MFRLLGPLTGWPSRRHSVRGGVGPVDRMAESPRSSDGFFLGSIIAKSLEVSIKQTFSYVLFLSTSTSLKSIMAITRVFVAGATGTQGGALARHLRAKNIEVHALARDIASQKAQDLVSIGVKFWVGDFNNKSALTIAITGCDALFLNFMPDLTNLSAEEQWAQSILDAGKEAGAQHVVFSSVYGVDQTDKMRWFDEKAAVAEIYASKHSIEKIVKASGYATWTVLRPGYFMANCVQPFVQFMLPGLAETGELITALRSDTVLPLTDTKTIGLFSSAAIMQPERFNGKTISYLDELLTLSEFIERLSQAVGRELKITYLSDDEVEAQRETNPILGGQLVTRDMAQFANLDQVKSLEVPLGTFEEYLKREREAVNATYNKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>B8MM70</accession>
    <name>B8MM70_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_098390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485820.1">
        <property type="nucleotide sequence ID" value="XM_002485775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MM70"/>
    <dbReference type="GeneID" id="8099667"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_098390"/>
    <dbReference type="eggNOG" id="ENOG502SMMJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007091_2_0_1"/>
    <dbReference type="InParanoid" id="B8MM70"/>
    <dbReference type="OMA" id="HMFLSMI"/>
    <dbReference type="OrthoDB" id="4337792at2759"/>
    <dbReference type="PhylomeDB" id="B8MM70"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF129">
        <property type="entry name" value="ASPYRIDONES CLUSTER REGULATOR APDR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED13582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="769" mass="86719" checksum="68CB4FF37F48B252" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNR8</accession>
    <name>B8MNR8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_103780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486395.1">
        <property type="nucleotide sequence ID" value="XM_002486350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNR8"/>
    <dbReference type="GeneID" id="8103081"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_103780"/>
    <dbReference type="HOGENOM" id="CLU_973786_0_0_1"/>
    <dbReference type="InParanoid" id="B8MNR8"/>
    <dbReference type="OrthoDB" id="4149149at2759"/>
    <dbReference type="PhylomeDB" id="B8MNR8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED14157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="286" mass="32690" checksum="B0A94AD487676757" modified="2009-03-03" version="1">MDPETEFDTDIMILDYVCSRATHALLLTRIAELSDRPAHAHLDLLNIFDTWQLLVSHKHSATRQISIDLQAKLQLISFTTRFFARARKSKWRDDNSRQQPAKKGGTFSNTAYMTMLEILRIPREERLDDRFRVLSLMDMFQGFLELCATMIGGMAVPDEDGIVEVLGKFIIQAVLEQYTLFGKTASDAIVEASSLLSRQNPIETTTKLLSTIQSSYLNLLHPPPVSSQQRESQETHLNRLAQQFPAFDFESMLIMKLQEFLFGLETPVLVKLETGEMDLYNEKNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNU2</accession>
    <name>B8MNU2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_104000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486419.1">
        <property type="nucleotide sequence ID" value="XM_002486374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNU2"/>
    <dbReference type="GeneID" id="8103172"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_104000"/>
    <dbReference type="HOGENOM" id="CLU_155384_1_0_1"/>
    <dbReference type="InParanoid" id="B8MNU2"/>
    <dbReference type="OrthoDB" id="4206436at2759"/>
    <dbReference type="PhylomeDB" id="B8MNU2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="92" mass="10364" checksum="5BFC08C4E250F53D" modified="2009-03-03" version="1">MRMSKAYETTMNDLVLVQKENRDLRAAHGKEKQKRQKSKKQISIEHGITGEEAQALVQDQVEASQAVTTAPGEPELPASQAVFIVRTQPYWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>B8MP12</accession>
    <name>B8MP12_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Polyketide synthase, putative</fullName>
            <ecNumber evidence="13">2.3.1.161</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_104650</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.161" evidence="13"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486489.1">
        <property type="nucleotide sequence ID" value="XM_002486444.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MP12"/>
    <dbReference type="GeneID" id="8103236"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_104650"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_31_0_1"/>
    <dbReference type="InParanoid" id="B8MP12"/>
    <dbReference type="OMA" id="KNAYHSA"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="PhylomeDB" id="B8MP12"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050637">
        <property type="term" value="F:lovastatin nonaketide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="30"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="1025"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2571"/>
            <end position="2651"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="9">
        <location>
            <begin position="1025"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="9">
        <location>
            <begin position="1190"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="9">
        <location>
            <position position="1057"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="9">
        <location>
            <position position="1258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED14251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="2652" mass="293187" checksum="CD79A3D1F48C196A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MP29</accession>
    <name>B8MP29_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aryl-alcohol dehydrogenase Aad14, putative</fullName>
            <ecNumber evidence="4">1.1.1.91</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_104820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.91" evidence="4"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486506.1">
        <property type="nucleotide sequence ID" value="XM_002486461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MP29"/>
    <dbReference type="FunCoup" id="B8MP29">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MP29"/>
    <dbReference type="GeneID" id="8098703"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_104820"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_2_1"/>
    <dbReference type="InParanoid" id="B8MP29"/>
    <dbReference type="OMA" id="MNYTHLG"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="PhylomeDB" id="B8MP29"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047681">
        <property type="term" value="F:aryl-alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF2">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="27"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED14268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="370" mass="41360" checksum="59B9182CDBF66E24" modified="2009-03-03" version="1">MSSDGSPPTDLGKLRVLSSTASIHVSPLALGGMSIGDAWASGMGSMDKESSFKLLDFYFESGGNFIDTSNNYQDEQSETWIGEWMSSRENRDQMVIATKYTTGYKTYELGKGRASNYVGNSRRSLHMSVRDSLQKLQTDYIDIFIEEIMDSLHILVEQGKVLYLGISDSPAWLASAANYYARAHGKTPFSIYQGRWNVMLRDFEREIIPMARYFGMALAPWDVLGGGKFQSRKALEERKSKGESLRKIFGSTGEQSKKEFKISEALAKVAEEHGMDSVQAIALAYVMSKAPRVFPIVGGRKIEHLKSNIDALRIRLSLEEIEYLESVVEFEPGFPNNFLGPHPRVVGKTSGWLMTDPVNLTFGAPEYDYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8MP61</accession>
    <name>B8MP61_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_105120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486538.1">
        <property type="nucleotide sequence ID" value="XM_002486493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MP61"/>
    <dbReference type="GeneID" id="8098733"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_105120"/>
    <dbReference type="eggNOG" id="ENOG502SF0B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107878_0_0_1"/>
    <dbReference type="InParanoid" id="B8MP61"/>
    <dbReference type="OMA" id="NSRAKWA"/>
    <dbReference type="OrthoDB" id="5153521at2759"/>
    <dbReference type="PhylomeDB" id="B8MP61"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="179" mass="19960" checksum="71913AABE401FD7B" modified="2009-03-03" version="1">MSDLRRSATGVKRVHNHKAKWAHGARQYGQQASSFDKWTKDSAGPVRLRPVPPTSSATQSVLRRYNESTIRSARNANDTYFQHDVKEALTSDSSSDETTILHESAAPDNMAIVDDDISAYAISGNNILAIAVSKAEVKYENKVTEKLAKEYEFVSREDDHVTGYIADVDDFEIIDHETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPH9</accession>
    <name>B8MPH9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_106270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486656.1">
        <property type="nucleotide sequence ID" value="XM_002486611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPH9"/>
    <dbReference type="GeneID" id="8098780"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_106270"/>
    <dbReference type="HOGENOM" id="CLU_094692_0_0_1"/>
    <dbReference type="InParanoid" id="B8MPH9"/>
    <dbReference type="PhylomeDB" id="B8MPH9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED14418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="257" mass="29176" checksum="459CC10978139D22" modified="2009-03-03" version="1">MTPKLYKEEEKLIAKALMPFQQYKHVHGRVVNKIARLGGFDFDKNDFFELRDIRIKTFTTRTIRHGWRERGIWPLNPRLILDTMLQPDEAFEALVAEGDALKIYGEADDTIPSSPTTKSISPPSTAVKLRRYVNKIEKSIDSIKNILDEVSPGLSRRIKVVNQGSLTLAELGDLHRESFAKVRDTATRKNQKTTKRQVKASGALYIKDANRLVKRRHDGDLLKIYKSHAVGVSQPTEEAASIEPQNSGFFFDTQGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPJ5</accession>
    <name>B8MPJ5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_106440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486672.1">
        <property type="nucleotide sequence ID" value="XM_002486627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPJ5"/>
    <dbReference type="STRING" id="441959.B8MPJ5"/>
    <dbReference type="GeneID" id="8106794"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_106440"/>
    <dbReference type="eggNOG" id="ENOG502SPA8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_903666_0_0_1"/>
    <dbReference type="InParanoid" id="B8MPJ5"/>
    <dbReference type="PhylomeDB" id="B8MPJ5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED14434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="308" mass="35018" checksum="99D31412E2E6B17D" modified="2009-03-03" version="1">MSLRTFYSSVVAPIPVQFVLDNLQYKFEDDIRHYNHPRWTANESNLLSIGDFTSQERQRVLGQSAYLARASACGPSLSISGRHPPSCREHAYKKGFLRSVIRTYRDAGHEAVTKELSQLRKALATDTQDTARKDYFHNAPVLEVDRQIEQPPGQVDVKDSNSSGFDGEDWELPILKYVFSERARLCLRQASSVSRVGEANRLSGIQKLHCLLNRNSRSVQQMSVLSVAVYLAAQHLTPPLHKFPRKRKDSLRRHLIDCCQMTRIFGEAEDRLFDLEGQPVTSSSYQRSIAIMLAHKSPSQKKFIKPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQ31</accession>
    <name>B8MQ31_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_055590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487168.1">
        <property type="nucleotide sequence ID" value="XM_002487123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQ31"/>
    <dbReference type="GeneID" id="8102252"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_055590"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="B8MQ31"/>
    <dbReference type="OMA" id="TWTMDNR"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="PhylomeDB" id="B8MQ31"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF27">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="501"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="563"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="167"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED13057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="632" mass="69609" checksum="532839C1BC8806CA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQ63</accession>
    <name>B8MQ63_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_055890</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487200.1">
        <property type="nucleotide sequence ID" value="XM_002487155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQ63"/>
    <dbReference type="STRING" id="441959.B8MQ63"/>
    <dbReference type="GeneID" id="8102282"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_055890"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_2_0_1"/>
    <dbReference type="InParanoid" id="B8MQ63"/>
    <dbReference type="OMA" id="ICTPAHR"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="PhylomeDB" id="B8MQ63"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF29">
        <property type="entry name" value="BETA-GLUCOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002875291" description="beta-glucosidase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="13">
        <location>
            <begin position="579"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED13089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="695" mass="75271" checksum="24FCEA61ECDD64AC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQ81</accession>
    <name>B8MQ81_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP citrate synthase</fullName>
            <ecNumber evidence="4">2.3.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSTA_056510</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="4"/>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487261.1">
        <property type="nucleotide sequence ID" value="XM_002487216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQ81"/>
    <dbReference type="STRING" id="441959.B8MQ81"/>
    <dbReference type="GeneID" id="8100714"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_056510"/>
    <dbReference type="eggNOG" id="KOG1254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006587_3_1_1"/>
    <dbReference type="InParanoid" id="B8MQ81"/>
    <dbReference type="OMA" id="DMHVSGI"/>
    <dbReference type="OrthoDB" id="5295093at2759"/>
    <dbReference type="PhylomeDB" id="B8MQ81"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000004">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.110:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032263">
        <property type="entry name" value="Citrate-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056749">
        <property type="entry name" value="Citrate_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF10">
        <property type="entry name" value="SUCCINATE--COA LIGASE [GDP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16114">
        <property type="entry name" value="Citrate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24948">
        <property type="entry name" value="Citrate_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-citrate synthase ATP-grasp" evidence="15">
        <location>
            <begin position="2"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase citrate-binding" evidence="14">
        <location>
            <begin position="296"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EED13150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="485" mass="52817" checksum="38CB180A8E1C715A" modified="2009-03-03" version="1">MSAKSIFEADGKAILNYHLTRAPVIKPTPLPRAATHNPPPKLASLYFPEDADINGVLDQAEATYPWLLAKDAKFVAKPDQLIKRRGKSGLLALNKTWPEARAWIEARAGKEIQVETVKGYLRQFLVEPFVPHPQETEYYININSVREGDWILFTHEGGVDVGDVDAKAEKILIPVNLKNYPSNEEIAATLLKKVPSGLHNVLVDFISRLYAVYVDCQFTYLEINPLVVIPNANATSAEVHFLDLAAKLDQTAEFECGTKWAIARSPSALGLPAPKGDGRVNIDAGPPMEFPAPFGRELSKEEKFIADMDAKTGASLKLTVLNANGRVWTLVAGGGASVVYADAIASAGFVSELANYGEYSGAPTETQTYNYARTVLDLMLRAPQHPEGKVLFIGGGIANFTNVASTFKGVIRALREVASTLNEHKVQIWVRRAGPNYQEGLKNIKAVGEELGLDMHVYGPDMHVSGIVPLALSGKKTDIKEFGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MR03</accession>
    <name>B8MR03_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_053560</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486949.1">
        <property type="nucleotide sequence ID" value="XM_002486904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MR03"/>
    <dbReference type="STRING" id="441959.B8MR03"/>
    <dbReference type="GeneID" id="8098307"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_053560"/>
    <dbReference type="eggNOG" id="KOG0139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_4_1_1"/>
    <dbReference type="InParanoid" id="B8MR03"/>
    <dbReference type="OMA" id="WADYCTA"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="PhylomeDB" id="B8MR03"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF17">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G16630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="28"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="157"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="262"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED12838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="437" mass="47996" checksum="EE34B0B322B9F399" modified="2009-03-03" version="1">MAPISRPVIAPYSEPLLPQLDIKNPHYTETHHHLRRYVRDYVETNIIPYAQEWEEAGEVPEEVRLRHCHLGFSIVHPLTSLEDADNIPLPGGVPREKWDTWCSLIVADELTRCGFVGVVWGLGGGNSIGAPSIARFGTPEQRKRWLPGVASGKTRFCLGITEPDAGSDVANISTTAKTEGDYYIVNGAKKWITNGLWADYCTAAVRTGGPGRKGVSVLVIPLKQKGVTRKRMHNSGVNASGSTFLEFDDVRVPADHLIGRVNEGFQIVMSNFNSERLSLACAALRLARVCVEDAFNYAVQRETFGAPLITRQAIQFKITKCGMLIEPAQSFLEQLVYIIETTKDRPNAGNIGGMTALLKVMSTRALEKCVREAQQIFGGAGYNKGGKGVRVEQISRDVRVHVVGGGSEEIMMGLALQEEIKALKSRQKASQEKTAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTB2</accession>
    <name>B8MTB2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_004130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488016.1">
        <property type="nucleotide sequence ID" value="XM_002487971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTB2"/>
    <dbReference type="STRING" id="441959.B8MTB2"/>
    <dbReference type="GeneID" id="8100124"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_004130"/>
    <dbReference type="HOGENOM" id="CLU_1455318_0_0_1"/>
    <dbReference type="InParanoid" id="B8MTB2"/>
    <dbReference type="OrthoDB" id="4224248at2759"/>
    <dbReference type="PhylomeDB" id="B8MTB2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="186" mass="20188" checksum="77802A71730C3A3B" modified="2009-03-03" version="1">MTQLTASALAAQEKSHAQGRVDSMHSHAAKVVHEERTHQYFSQLGILKGIDIINAEYWDGGNTGACTRTGTGAGGCSRANRDDALPDTARRDNSDNSNGGDLLQSLKIFVPHLVEDSGTTPLERFLTLGESTDPSYIRHPALTQAQYYGNMDSVETRISQAHVSADRIISEGQARKGSTGDEHMYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTQ9</accession>
    <name>B8MTQ9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2423 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_005730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488198.1">
        <property type="nucleotide sequence ID" value="XM_002488153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTQ9"/>
    <dbReference type="GeneID" id="8105547"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_005730"/>
    <dbReference type="eggNOG" id="ENOG502SXGY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149452_0_0_1"/>
    <dbReference type="InParanoid" id="B8MTQ9"/>
    <dbReference type="OMA" id="PIIREHK"/>
    <dbReference type="OrthoDB" id="4087970at2759"/>
    <dbReference type="PhylomeDB" id="B8MTQ9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019434">
        <property type="entry name" value="DUF2423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28219">
        <property type="entry name" value="UPF0642 PROTEIN YBL028C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28219:SF1">
        <property type="entry name" value="UPF0642 PROTEIN YBL028C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10338">
        <property type="entry name" value="YBL028C_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2423" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED12544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="121" mass="13695" checksum="83679F33A28147BF" modified="2009-03-03" version="1">MAKSIRSSTKKRNHAKLRSTVFGPVADARTERLSAKLQELAAQPLKIETSKDSSEENTKTEAGVEDESDKMVIDESAATKSSSTKQRSNRVRKQIKRKPRNKMVFSKPHQGKQQRKTQKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUA6</accession>
    <name>B8MUA6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB/POZ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_108010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488367.1">
        <property type="nucleotide sequence ID" value="XM_002488322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUA6"/>
    <dbReference type="STRING" id="441959.B8MUA6"/>
    <dbReference type="GeneID" id="8106865"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_108010"/>
    <dbReference type="eggNOG" id="ENOG502SQDU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8MUA6"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="PhylomeDB" id="B8MUA6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="59"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED11611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="277" mass="31754" checksum="E94BE6B088FD1471" modified="2009-03-03" version="1">MPTKKKKKDRKRNKPELDLELDDDNHTQETQSITSDDDSAEMLNLLARYECLYLNPQYSDLTIICGTEVFPVHRNIVCPRSSYFARSCGGNFKEALGTIELKDQDPNLIRKVLQFLYTGDYTFEIDGDEEKEDNLGQPSSQDHSRGFNACQFHVRMYAQADYFQIDGLKSRAERYFRGSFLDQPSKDPFEAIITEIYTSIPESDEQIRDAAIELTMDNLETLRNGTEVILLDGFLKRSPAFAADLCIAMLKRRSESQKEEIFRPAASKPLFTLYGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8MV64</accession>
    <name>B8MV64_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transposable element tc3 transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_008160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962662">
        <property type="protein sequence ID" value="EED11520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488701.1">
        <property type="nucleotide sequence ID" value="XM_002488656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MV64"/>
    <dbReference type="STRING" id="441959.B8MV64"/>
    <dbReference type="GeneID" id="8110153"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_008160"/>
    <dbReference type="eggNOG" id="ENOG502QUTZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033666_0_1_1"/>
    <dbReference type="InParanoid" id="B8MV64"/>
    <dbReference type="OrthoDB" id="5415741at2759"/>
    <dbReference type="PhylomeDB" id="B8MV64"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="1">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="2">
        <location>
            <begin position="157"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED11520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="31594" checksum="EEB061EC62D016D7" modified="2009-03-03" version="1">MKDAEIDDLISFVTSSRYARYLTYRELALHLDLGYSQWAIRSALLSRGYRRYVARRKPPLSPENKQKRLLWAQEYLSWSPSQWEAILWSDEIWVNPGHHTRTWVTRRKDEVFHEDCTIERRPHKIGWMFWGSFHGTTKGPMVFWEKQWEYSHQHPYLQLVQDGAPGYGAQSTIQELEKGGVHMVRWPPFSPDLNLIEMVWNWMKNYLQVNLGLGAHLKEPGPNRTAPQDGAVQFQLLRTAGRFHDFRNRTALNAVRTSGSTNSTNREIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MVD4</accession>
    <name>B8MVD4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_007840</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962663">
        <property type="protein sequence ID" value="EED11494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488810.1">
        <property type="nucleotide sequence ID" value="XM_002488765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MVD4"/>
    <dbReference type="STRING" id="441959.B8MVD4"/>
    <dbReference type="GeneID" id="8103458"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_007840"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_4_1"/>
    <dbReference type="InParanoid" id="B8MVD4"/>
    <dbReference type="OMA" id="SDVKQAH"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="PhylomeDB" id="B8MVD4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED11494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="522" mass="60306" checksum="2186C29D0CBC983E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MVL1</accession>
    <name>B8MVL1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposon I factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_080460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962664">
        <property type="protein sequence ID" value="EED11435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488845.1">
        <property type="nucleotide sequence ID" value="XM_002488800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MVL1"/>
    <dbReference type="STRING" id="441959.B8MVL1"/>
    <dbReference type="GeneID" id="8108969"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_080460"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_23_2_1"/>
    <dbReference type="InParanoid" id="B8MVL1"/>
    <dbReference type="OMA" id="DCHYSWR"/>
    <dbReference type="OrthoDB" id="4368687at2759"/>
    <dbReference type="PhylomeDB" id="B8MVL1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="335"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="3">
        <location>
            <begin position="809"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1116"/>
            <end position="1139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED11435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1139" mass="129114" checksum="2CEF1973B8058644" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>H9CNL9</accession>
    <name>H9CNL9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">ATP synthase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_m0100</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="14"/>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="BMC Genomics" volume="13" first="698" last="698">
            <title>Sequencing of mitochondrial genomes of nine Aspergillus and Penicillium species identifies mobile introns and accessory genes as main sources of genome size variability.</title>
            <authorList>
                <person name="Joardar V."/>
                <person name="Abrams N.F."/>
                <person name="Hostetler J."/>
                <person name="Paukstelis P.J."/>
                <person name="Pakala S."/>
                <person name="Pakala S.B."/>
                <person name="Zafar N."/>
                <person name="Abolude O.O."/>
                <person name="Payne G."/>
                <person name="Andrianopoulos A."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="23234273"/>
            <dbReference type="DOI" id="10.1186/1471-2164-13-698"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase A chain family.</text>
    </comment>
    <dbReference type="EMBL" id="JQ354994">
        <property type="protein sequence ID" value="AFD95913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9CNL9"/>
    <dbReference type="FunCoup" id="H9CNL9">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="STRING" id="441959.H9CNL9"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_m0100"/>
    <dbReference type="InParanoid" id="H9CNL9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00310">
        <property type="entry name" value="ATP-synt_Fo_a_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.220:FF:000003">
        <property type="entry name" value="ATP synthase subunit a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="entry name" value="ATP synthase, F0 complex, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045083">
        <property type="entry name" value="ATP_synth_F0_asu_bact/mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004482">
        <property type="entry name" value="PRK05815.2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11410">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11410:SF0">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="F1F0 ATP synthase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0138">CF(0)</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFD95913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="256" mass="28305" checksum="D7587080FAA367DB" modified="2012-05-16" version="1">MQVNFILSPLDQFEIRDLLSLNISLLNNTHISLTNIGLYLSVGIVLIISYSLLATNNNKIIPNNWSLSQETLYFTVHGIVINQINSNKGQVYFPFIYSLFIFILANNLLGMIPYSFASTSHFVLTFSMSFTVVLGATILGFQKHGLKFFSLFVPSGCPLGLLPLLVLIEFISYLSRNVSLGLRLAANILSGHMLLSILGGFTYNIMTSGLLFFFLGLLPLAFIIAFSGLELAIAFIQAQVFVVLSCSYIKDGLDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B8LT32</accession>
    <name>B8LT32_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arginine N-methyltransferase 2</fullName>
            <ecNumber evidence="8">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_069580</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340927.1">
        <property type="nucleotide sequence ID" value="XM_002340886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LT32"/>
    <dbReference type="FunCoup" id="B8LT32">
        <property type="interactions" value="375"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LT32"/>
    <dbReference type="GeneID" id="8102694"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_069580"/>
    <dbReference type="eggNOG" id="KOG1709">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033831_0_0_1"/>
    <dbReference type="InParanoid" id="B8LT32"/>
    <dbReference type="OMA" id="YWVVDNY"/>
    <dbReference type="OrthoDB" id="19014at2759"/>
    <dbReference type="PhylomeDB" id="B8LT32"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019702">
        <property type="term" value="F:protein arginine N5-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000135">
        <property type="entry name" value="Arginine N-methyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017408">
        <property type="entry name" value="Arginine_N-MeTrfase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051038">
        <property type="entry name" value="RMT2/GAMT_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026480">
        <property type="entry name" value="RMT2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379:SF1">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038148">
        <property type="entry name" value="Arginine_N-mtfrase-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51559">
        <property type="entry name" value="SAM_RMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RMT2" evidence="10">
        <location>
            <begin position="176"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED23540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="409" mass="46624" checksum="A579A7587EDA1A7C" modified="2009-03-03" version="1">MTDIIETIDVDLDIQEILLAASQHNIPKLRQLLRSNHAGAENPANIKDTETGYSPLHAAIAACEPDDAEEKKDGEVNGEEKEEGELALARETVKFLLQEGAIWNDLDKNDETPGCLARKLGLMELYELMVDAGVRAELLFNRLEGYEMLVDDDDDDEEEGQKEENEEKEHEEAEHKNVTNVRYLHSNLTFQNDRLLDNDQNGVMMSWESDIMRKTALKILPAPGLRVLNIGHGMGIVDGFFQDQSPATHHIVEAHAEVIEEMRRKGWHEKPGVVIHHGRWQDILPQLVEQGELFDAIYYDTFAESYADFREFLSEQVIGLLDSDGLWSFFNGMGADRQISYDVYQKVVEMDVFEAGFDVAWEDVPVPPLDGEWNGVRRKYWVVDNYRLPLSWGVYKVKPATNPPSRVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTE8</accession>
    <name>B8LTE8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_064890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340413.1">
        <property type="nucleotide sequence ID" value="XM_002340372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTE8"/>
    <dbReference type="FunCoup" id="B8LTE8">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LTE8"/>
    <dbReference type="GeneID" id="8105994"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_064890"/>
    <dbReference type="eggNOG" id="KOG0372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_8_1_1"/>
    <dbReference type="InParanoid" id="B8LTE8"/>
    <dbReference type="OMA" id="KIGGYPP"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="PhylomeDB" id="B8LTE8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901525">
        <property type="term" value="P:negative regulation of mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="6">
        <location>
            <begin position="114"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED23026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="320" mass="36379" checksum="720BE2B0F140A5B5" modified="2009-03-03" version="1">MPGLPSSIDLDECIERLYKKQLLADSVIEAICAKAKELLMKESNVVHIAAPVTVVGDIHGQFFDMIEIFKIGGFCPNTNYLFLGDYVDRGLFSVETISLLVCLKLRYPSRVHLIRGNHESRGVTQSYGFYTECARKYGNANVWHYFTDMFDFLTLSVVINDQIFCVHGGLSPSIHSIDQIKIIDRFREIPHEGPMADLVWSDPDIEHDEFSLSPRGAGYTFGAQVVRKFLEVNSMSHILRAHQLCQEGYQVLYDDRLSTVWSAPNYCYRCGNLASVLEVSDSGERFFNIFGAAPENDEHRNEQQTQPNKDSQNPVIEYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8LU16</accession>
    <name>B8LU16_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retrovirus polyprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_072390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341233.1">
        <property type="nucleotide sequence ID" value="XM_002341192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LU16"/>
    <dbReference type="STRING" id="441959.B8LU16"/>
    <dbReference type="GeneID" id="8101131"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_072390"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_33_7_1"/>
    <dbReference type="InParanoid" id="B8LU16"/>
    <dbReference type="OMA" id="CEVVFRI"/>
    <dbReference type="OrthoDB" id="4499277at2759"/>
    <dbReference type="PhylomeDB" id="B8LU16"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="305" mass="35213" checksum="C6BBC5933016E6F1" modified="2009-03-03" version="1">MSLEELEAARECIIDNLNKGFIESSNAPFTSPMIMAEKPGGGLRFCVDYRKLNKLTKKDRYPFPLIEEIFKRLSRARIFTKLDIRQCFHRIRMHTDSKDLTTFRCRYGTYKYKIKPFVNPNGHATLQRLVHDLFIDDLDQFLIAFIDGLLIYSENELEHEIHVQRVLKRLRSTGLQAALHKCEFHVTETKFLGFILAPDGIKVDQGKVEIIINWTVSTTVFGCEVVFRILWILPEVHTKPYQNREINVLFDWTKECQEAFEELKKRLVSAPVSCHYRPGLPTGLEADAPDGIVAAVPSQLQEDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUA7</accession>
    <name>B8LUA7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450 oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_060710</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002339966.1">
        <property type="nucleotide sequence ID" value="XM_002339925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUA7"/>
    <dbReference type="STRING" id="441959.B8LUA7"/>
    <dbReference type="GeneID" id="8108630"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_060710"/>
    <dbReference type="eggNOG" id="KOG0159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="InParanoid" id="B8LUA7"/>
    <dbReference type="OMA" id="PWVINRH"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="PhylomeDB" id="B8LUA7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF175">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE PKFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED22579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="523" mass="60129" checksum="4F2BCEDC63C03EA0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUC6</accession>
    <name>B8LUC6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF974 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_071020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341086.1">
        <property type="nucleotide sequence ID" value="XM_002341045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUC6"/>
    <dbReference type="STRING" id="441959.B8LUC6"/>
    <dbReference type="GeneID" id="8105661"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_071020"/>
    <dbReference type="eggNOG" id="KOG2625">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027041_1_1_1"/>
    <dbReference type="InParanoid" id="B8LUC6"/>
    <dbReference type="OMA" id="YLCVHNG"/>
    <dbReference type="OrthoDB" id="10250284at2759"/>
    <dbReference type="PhylomeDB" id="B8LUC6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010378">
        <property type="entry name" value="TRAPPC13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055429">
        <property type="entry name" value="TRAPPC13_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055427">
        <property type="entry name" value="TRAPPC13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23647">
        <property type="entry name" value="TRAPPC13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06159">
        <property type="entry name" value="TRAPPC13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 N-terminal" evidence="2">
        <location>
            <begin position="17"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 middle" evidence="3">
        <location>
            <begin position="232"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED23699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="345" mass="38130" checksum="C74676872851B447" modified="2009-03-03" version="1">MARPRAHSGADGPKEPHSVSLKVLRLSRPSLSYQYPLPREDTRISSKASLAYPSNDFDPHFILSPNVTLPPAFGSAYVGETFACSLCANNELPETDSTKKVTSVRILAEMQTPSQVFPLDLKPGEDEHQDETLPKPGKGLDYGQSLQKIVQFDLKEEGNHILAVSVSYTETLLADANATTASSGRVRTFRKLYQFIAQPCLSVRTKASELVPAEVENKSLGPYGKTRLLRFALEAQLENVGDGSVVIEKTILNAKPPFKSQSLNWDIHHFPSSSTSEQPTMNPRDILQVAFLVEQEVGQHDGLENLQKELKRDGRAILGQLSIEWRSAMGDRGFLTTGNLMTKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUD8</accession>
    <name>B8LUD8_TALSN</name>
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        <recommendedName>
            <fullName evidence="2">Small EDRK-rich factor-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_071140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341098.1">
        <property type="nucleotide sequence ID" value="XM_002341057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUD8"/>
    <dbReference type="FunCoup" id="B8LUD8">
        <property type="interactions" value="225"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LUD8"/>
    <dbReference type="GeneID" id="8107627"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_071140"/>
    <dbReference type="eggNOG" id="KOG4488">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165034_2_0_1"/>
    <dbReference type="InParanoid" id="B8LUD8"/>
    <dbReference type="OMA" id="NTMSGTE"/>
    <dbReference type="OrthoDB" id="18018at2759"/>
    <dbReference type="PhylomeDB" id="B8LUD8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED23711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="65" mass="7321" checksum="AFE0FF98F4A88078" modified="2009-03-03" version="1">MTRGNQRENARKKNLEKQAKAKSKNTMSGTEYQREKEKAAEIMREKQRKALEKKAAEAAAGGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUQ8</accession>
    <name>B8LUQ8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_073050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341302.1">
        <property type="nucleotide sequence ID" value="XM_002341261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUQ8"/>
    <dbReference type="GeneID" id="8110222"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_073050"/>
    <dbReference type="eggNOG" id="ENOG502SSTB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150197_0_1_1"/>
    <dbReference type="InParanoid" id="B8LUQ8"/>
    <dbReference type="OMA" id="GWVGYQI"/>
    <dbReference type="OrthoDB" id="4083871at2759"/>
    <dbReference type="PhylomeDB" id="B8LUQ8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42077">
        <property type="entry name" value="YALI0F30239P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42077:SF1">
        <property type="entry name" value="YALI0F30239P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877389" evidence="1">
        <location>
            <begin position="25"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="103" mass="11672" checksum="52137035D6B2955E" modified="2009-03-03" version="1">MANSIIPLIILLLVVALFSAIGFAVYTIAQDVSSNTRAKMEKRNISFSKEGMKVSVKEKRDEEYKDQTQSVLVKVWNNTSFPAYKSRLWDNGASGKEDDVKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVQ2</accession>
    <name>B8LVQ2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Heat shock protein/chaperonin HSP78, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_075540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341569.1">
        <property type="nucleotide sequence ID" value="XM_002341528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVQ2"/>
    <dbReference type="FunCoup" id="B8LVQ2">
        <property type="interactions" value="231"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LVQ2"/>
    <dbReference type="GeneID" id="8099980"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_075540"/>
    <dbReference type="eggNOG" id="KOG1051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_0_1"/>
    <dbReference type="InParanoid" id="B8LVQ2"/>
    <dbReference type="OMA" id="VSKMMQG"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="PhylomeDB" id="B8LVQ2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000017">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF176">
        <property type="entry name" value="HEAT SHOCK PROTEIN 78, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="121"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="519"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="9">
        <location>
            <begin position="697"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="334"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED24182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="791" mass="87997" checksum="61E94D42BA04008D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVV6</accession>
    <name>B8LVV6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Proline utilization protein PrnX, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_076890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341709.1">
        <property type="nucleotide sequence ID" value="XM_002341668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVV6"/>
    <dbReference type="FunCoup" id="B8LVV6">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LVV6"/>
    <dbReference type="GeneID" id="8102440"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_076890"/>
    <dbReference type="eggNOG" id="KOG3007">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042088_0_1_1"/>
    <dbReference type="InParanoid" id="B8LVV6"/>
    <dbReference type="OMA" id="CVGMGLM"/>
    <dbReference type="OrthoDB" id="41492at2759"/>
    <dbReference type="PhylomeDB" id="B8LVV6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF23">
        <property type="entry name" value="PRNX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED24322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="342" mass="38446" checksum="22A36FD529EDC824" modified="2009-03-03" version="1">MLAVSERDLTKLLHNLNHHETHLLLQHLSTALHAFSAQHRGTTTENTNIINQPQRTSIINEKWESTTLFMPVSDYQSTGFKVVTVPKVTKATNAIRGVINILSPEGRLEGVMSAAEITAFRTALASMILFSRFYDTKEKKKKILIFGSGKQAEWHARLAFQRRLEESISSKLVPDLRGRYPHLDIETYSREEQTQDVYQSRLRADLARSDAIFCCTPSTEPLFTYNDLTASSNKRRFISLIGSYKPHMQEIDSRTLLSGVKGRIYVDSVEACMEEAGELIMAKVDEKQLIELGEVDPTLPLEEKEGNVIFKCVGLGIMDLVIARNLLKMASEQGLGTVVDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVY6</accession>
    <name>B8LVY6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endoglucanase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_077190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341739.1">
        <property type="nucleotide sequence ID" value="XM_002341698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVY6"/>
    <dbReference type="SMR" id="B8LVY6"/>
    <dbReference type="STRING" id="441959.B8LVY6"/>
    <dbReference type="GeneID" id="8101053"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_077190"/>
    <dbReference type="eggNOG" id="ENOG502SH4Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051064_0_1_1"/>
    <dbReference type="InParanoid" id="B8LVY6"/>
    <dbReference type="OrthoDB" id="89349at2759"/>
    <dbReference type="PhylomeDB" id="B8LVY6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF10">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012722942" evidence="3">
        <location>
            <begin position="16"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED24352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="237" mass="25805" checksum="C8542478223C949E" modified="2009-03-03" version="1">MKLSLLLSLAAAAYAQQQSLCSQYSSYTSGPYTVNNNLWGESSGSGSQCTYVNSISSSGVAWSTTWNWSGSNSQVKSYANSQYSALNKKLVSQLSSIPTSVQWSYSNTAITADVSYDLFTAADINHVTYSGDYELMIWLGRYGGAQPLGSQIGTANVAGITWQLWYGVNGSQKTYSFVAPSQTTSWSGDILNFFDYLEEHQNFPASSQYLIDLQFGTEPFTGSQTTLTVNHWSASAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8LW31</accession>
    <name>B8LW31_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Quinone oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_074370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341446.1">
        <property type="nucleotide sequence ID" value="XM_002341405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LW31"/>
    <dbReference type="STRING" id="441959.B8LW31"/>
    <dbReference type="GeneID" id="8101274"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_074370"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_1_1"/>
    <dbReference type="InParanoid" id="B8LW31"/>
    <dbReference type="OMA" id="EAYKEPY"/>
    <dbReference type="OrthoDB" id="256333at2759"/>
    <dbReference type="PhylomeDB" id="B8LW31"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="72"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED24059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="427" mass="45791" checksum="67A2596F73E46839" modified="2009-03-03" version="1">MLKFVKRLGSRQDLRGWKEISNKSGANRDITSIASSDSSPSLGSHKPMTVTYEVPSDITYDVPATMKAQQLDAYNTPYVFRDSVPVPTPTHPYDLLIRVDAASYCHTDYVLASGHMASVEQPVFPHAGCHEFSGTVVALPPNSAQSDFKIGDRVGVSCRPYHACGECAECVEEDSPDSDPKGYSVLCPTIKSQGIGIPGGFQEYVLVDARQLTIIPPGLSQVEAAPLMCAGITIYAAIKKTGLKPGQRIGIIGCGGGLGHLGLQYATAMGLKVYGVENADRPLALARGLKNISGATIIDSRTTTAAEAIAHISTEDKRPIPGQFGLDAVIILPESQKAFQYGVDMLKNHGKCVVVSFPPQGFHMTDIHYVGNVSGSIKQLREMTAFSAKHGIKAQIEVFPLEKLNDLVKAYLSGHGGKLVIDYHHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWK3</accession>
    <name>B8LWK3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SET domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_077590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341787.1">
        <property type="nucleotide sequence ID" value="XM_002341746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWK3"/>
    <dbReference type="STRING" id="441959.B8LWK3"/>
    <dbReference type="GeneID" id="8101951"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_077590"/>
    <dbReference type="eggNOG" id="KOG1337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_393276_0_0_1"/>
    <dbReference type="InParanoid" id="B8LWK3"/>
    <dbReference type="OMA" id="YVFNIFY"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="PhylomeDB" id="B8LWK3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF135">
        <property type="entry name" value="SET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G11040)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED24400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="739" mass="83550" checksum="B4F9CB4FA23801CD" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWM9</accession>
    <name>B8LWM9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_077850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341813.1">
        <property type="nucleotide sequence ID" value="XM_002341772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWM9"/>
    <dbReference type="STRING" id="441959.B8LWM9"/>
    <dbReference type="GeneID" id="8105603"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_077850"/>
    <dbReference type="eggNOG" id="ENOG502SN8F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_680033_0_0_1"/>
    <dbReference type="InParanoid" id="B8LWM9"/>
    <dbReference type="OMA" id="WTLGPIK"/>
    <dbReference type="OrthoDB" id="5206740at2759"/>
    <dbReference type="PhylomeDB" id="B8LWM9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED24426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="405" mass="44105" checksum="51598A0225B3E1EA" modified="2009-03-03" version="1">MSFLLEVHGLRQAIVLEAYLETSTGTCKVGTLRCDYAVCSHKERMAGAYINAGDSRWTLFGWPTSVWLPVKSKSELNALSHISPVPRESPPSVSHTTAQKMIAITTTATPSVMHNTTITKRPKLSLQTTSLPATFGNSNTGLVARSCITASPTVRNTFSNAYDIRQTLSAIDSPSPSCRSADRSARHGSPFPFSNYRSDPMPYQQPLGVRSILRNSPLKKLSLGRRSVSISAGAIDNRRVYFPAKKQVSFRNQLEEEIKTVRYVARHSDIDSESEPELISDGADGSSSESSDSSESQSEHSSSGEDDGEAQDRPVRRRKRKSAPSERQIRAAALRDGLNNDRIAAALSAVPDSNSQKRRCKWRWTLGNSPSAEAESNLDTIPSAETIQSPPALNTGNDTVISGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWN9</accession>
    <name>B8LWN9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_077980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341823.1">
        <property type="nucleotide sequence ID" value="XM_002341782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWN9"/>
    <dbReference type="FunCoup" id="B8LWN9">
        <property type="interactions" value="1113"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LWN9"/>
    <dbReference type="GeneID" id="8105633"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_077980"/>
    <dbReference type="eggNOG" id="KOG1646">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046346_0_0_1"/>
    <dbReference type="InParanoid" id="B8LWN9"/>
    <dbReference type="OMA" id="KPRYKAP"/>
    <dbReference type="OrthoDB" id="10260596at2759"/>
    <dbReference type="PhylomeDB" id="B8LWN9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED24436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="237" mass="27156" checksum="8AD6CA3AABE7E9AD" modified="2009-03-03" version="1">MKLNISYPANGSQKLIEIDDERKLRAFMEKRMGTEVPGDGLGDEFKGYLFKITGGNDKQGFPMKQGVLLPNRVKLLLSDGHSCYRPRRTGERKRKSIRGAITGQDLAVLALSIVKQGENEIPGLTDVVNPKRLGPKRATKIRKFFGLDKKDDVRKFVIRRTVTKEGKKDYTKAPKIQRLVTPQRLQRKRHRIAIKRRRAEAAREAANDYAKLLASRVHEEKAKRTELRKRRASSLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWW5</accession>
    <name>B8LWW5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_079530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341985.1">
        <property type="nucleotide sequence ID" value="XM_002341944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWW5"/>
    <dbReference type="STRING" id="441959.B8LWW5"/>
    <dbReference type="GeneID" id="8105086"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_079530"/>
    <dbReference type="eggNOG" id="ENOG502SQ1T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_508153_0_0_1"/>
    <dbReference type="InParanoid" id="B8LWW5"/>
    <dbReference type="OMA" id="KCPGYRP"/>
    <dbReference type="OrthoDB" id="4491390at2759"/>
    <dbReference type="PhylomeDB" id="B8LWW5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED24598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="537" mass="60707" checksum="23DDDA6F10A5AE40" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8LX22</accession>
    <name>B8LX22_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc binding dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_061600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340059.1">
        <property type="nucleotide sequence ID" value="XM_002340018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LX22"/>
    <dbReference type="STRING" id="441959.B8LX22"/>
    <dbReference type="GeneID" id="8105631"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_061600"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_5_1"/>
    <dbReference type="InParanoid" id="B8LX22"/>
    <dbReference type="OMA" id="FTRTISY"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="PhylomeDB" id="B8LX22"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="14"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED22672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="331" mass="35315" checksum="3950ADBA5186E70F" modified="2009-03-03" version="1">MSSNTAAWITEAKKAPLEVKEAPLWTPKENEVLVKNQAVAVNPIDGSVQQFAYLPLSYPSILGTDVAGEIIAVGPNVARWKIGDRIVGHGLVLWDFKPEGAAFQHYTILVANMAAEIPDHISFQDAVVLPLCLSTAATSLFHDDYMGLQLPTCPPQKTTGETLVIWGGASCVGSNGYEVITTASPKNFDYVKNLGADQVFDYSSPTVADDIVDALKGKLLAGILDSIGFSATQFCLDIAHRSRGFKFVSTTKPRFPNPPEGVQIKHVRGDALVANSLGKSIYEDFLPKALKCGSYVAAPKPTVIGKGLESVQAGIDAVMKGVSATKIVITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXY4</accession>
    <name>B8LXY4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Steroid dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_062860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340186.1">
        <property type="nucleotide sequence ID" value="XM_002340145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXY4"/>
    <dbReference type="STRING" id="441959.B8LXY4"/>
    <dbReference type="GeneID" id="8101991"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_062860"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="InParanoid" id="B8LXY4"/>
    <dbReference type="OMA" id="WGRFHPN"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="PhylomeDB" id="B8LXY4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED22799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="333" mass="36078" checksum="CE69F26A75E60C91" modified="2009-03-03" version="1">MQITHFMGATWSQFFPPHPTLTETNLPSQKGKVFIVTGGYSGVGYELVAILYQAGAKVYLAGRSEEKANAAIAEIKAQPTKKDLSETGEIVFLHLSLDDLTTIKPAVEKFTSAESRLDVLFNNAGVSNPPTGSVSAQGHELQLATNVLGPHLLTQLLLPTLRNTAKSLPPGSVRVIWTSSIADQLQAPKNGIELSELERPHSDPQHNYTLSKLGNWYLAHGLAKQAGSDGILTVTQNPGNLKSNLTRHLPSYVAILAGPLLHHARKGAYTELWAGLSPDLKIEDNGKYVVPWGRLHPNPRQDLLATMKSKDEGGNGVAAIFLEFADKQIADFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYX0</accession>
    <name>B8LYX0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_069010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340865.1">
        <property type="nucleotide sequence ID" value="XM_002340824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYX0"/>
    <dbReference type="FunCoup" id="B8LYX0">
        <property type="interactions" value="354"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LYX0"/>
    <dbReference type="GeneID" id="8108636"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_069010"/>
    <dbReference type="eggNOG" id="KOG3191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018398_6_1_1"/>
    <dbReference type="InParanoid" id="B8LYX0"/>
    <dbReference type="OMA" id="DVNRNAC"/>
    <dbReference type="OrthoDB" id="406152at2759"/>
    <dbReference type="PhylomeDB" id="B8LYX0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000274">
        <property type="entry name" value="ERF1 methyltransferase catalytic subunit MTQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED23478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="246" mass="27001" checksum="8B61D3FB2C25C753" modified="2009-03-03" version="1">MLPTPSTSHVSFDTIYEPAEDSFLLLDTLSSASEAAWLTDRFQISKSSASPLIVEVGSGSGVVIAFTAANSKHIFDVNRDACQATRQTVQTAISETGNASRTHYLSSLTGDLVSPLKPGSVDVLLFNPPYVPTPDLPILPQPRQNETKSLSRSEKFEHDSYLLSLSYAGGLDGMETTNRFIEAIPSILNPERGVAYLLLCAQNKPEDVRARIIRGWHGWTADMVGRSGMQAGWEKLVILRIYRNEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0C7</accession>
    <name>B8M0C7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_084550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478187.1">
        <property type="nucleotide sequence ID" value="XM_002478142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0C7"/>
    <dbReference type="STRING" id="441959.B8M0C7"/>
    <dbReference type="GeneID" id="8102737"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_084550"/>
    <dbReference type="eggNOG" id="ENOG502SUXP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114624_0_0_1"/>
    <dbReference type="InParanoid" id="B8M0C7"/>
    <dbReference type="OMA" id="YVANAWL"/>
    <dbReference type="OrthoDB" id="4358740at2759"/>
    <dbReference type="PhylomeDB" id="B8M0C7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="192" mass="21598" checksum="BAC6FD8BD1FF1466" modified="2009-03-03" version="1">MKNEGSGLEDAKVSVITPIWRNNPQERQVLGKGDRQFPMNAKRPLRVLTIVSNKSPAWEQSPEGIIQFALRVIAENNLYDVTEISVSNTKLLAIQYYRVRKMFVFDISNESYDPAKGHLPEENELPVVVIHLSNRNIASRPHPGECARINETVRYLHDANGFGSTPPFVENHTSGTPPNYPNPRSLRRSGAP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-07-27" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0Z4</accession>
    <name>AMPP3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName>Probable Xaa-Pro aminopeptidase pepP</fullName>
            <ecNumber>3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Prolidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">pepP</name>
        <name type="ORF">TSTA_090130</name>
    </gene>
    <organism>
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478737.1">
        <property type="nucleotide sequence ID" value="XM_002478692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0Z4"/>
    <dbReference type="SMR" id="B8M0Z4"/>
    <dbReference type="FunCoup" id="B8M0Z4">
        <property type="interactions" value="434"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M0Z4"/>
    <dbReference type="GeneID" id="8108101"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_090130"/>
    <dbReference type="eggNOG" id="KOG2737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_1_2_1"/>
    <dbReference type="InParanoid" id="B8M0Z4"/>
    <dbReference type="OMA" id="DAHALFF"/>
    <dbReference type="OrthoDB" id="10261878at2759"/>
    <dbReference type="PhylomeDB" id="B8M0Z4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000002">
        <property type="entry name" value="Xaa-Pro aminopeptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF1">
        <property type="entry name" value="XAA-PRO DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0031">Aminopeptidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000411890" description="Probable Xaa-Pro aminopeptidase pepP">
        <location>
            <begin position="1"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="468" mass="52215" checksum="428A6E4138641D19" modified="2009-03-03" version="1">MTSTEGILAGKYPAKAHARRVVEYLRQNGFEGDGVLYLEAQKTKMIEDNDSEQPFRQRRFFFYLSGCLLPDAHLTYHISSDKLALFIPPLDPESVIWSGLPLSPTQAKELYDVDEVLYTTDINPTLAHLASEVGTSGFVFAIDGQISDDISFKNFPETDLVALKTAIEECRVVKDAYEVAMIRKANDVTAQAHVAVLKATKSATNERELEAAFIGTCIAHGCREMAYHPIVASGTSSATLHYVNNDEPLIDLTTNKKKLNLLLDAAGEYKTYCADVTRTFPLSGKFSPESRQIYDIVLEMQTKSLAMLKEGVLWEDVHVTAHRVAIKGLLKLGILRGSEEELLEKRISVAFFPHGLGHYLGMDTHDTGGHANYADKDKMFRYLRVRGKLPAGSVITVEPGVYFCRFIIEPYLKDSELSKYIDADVLEKYWEVGGVRIEDNIHITKEGYDNLTTAPKTADQLELMINGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8M150</accession>
    <name>B8M150_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell surface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_082250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477955.1">
        <property type="nucleotide sequence ID" value="XM_002477910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M150"/>
    <dbReference type="STRING" id="441959.B8M150"/>
    <dbReference type="GeneID" id="8107683"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_082250"/>
    <dbReference type="eggNOG" id="ENOG502S5EQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037529_0_0_1"/>
    <dbReference type="InParanoid" id="B8M150"/>
    <dbReference type="OMA" id="MGMKSHG"/>
    <dbReference type="OrthoDB" id="2590867at2759"/>
    <dbReference type="PhylomeDB" id="B8M150"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39606:SF1">
        <property type="entry name" value="CELL SURFACE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39606">
        <property type="entry name" value="SURFACE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="216" mass="21830" checksum="B87A0C1378DBBEED" modified="2009-03-03" version="1">MSNIVHKVKDAVTNHHDKPSHSTNAGPHDSNVANKVDPRVDSDRDHRAGYSAAGTGNTTAGTGISSGTGTTGTSYGAGTSGYDSTNTTASGPHGSNLANKADPRVDSDRGQYGTTGGVTAGGAYNSNPSSTNAGPHSSNLANKADPRVDSDLDNRARHQNLGSNTAPAGSSYTTPGSGGAQQTAGPHDSNIANKLDPRVDSDLDNSRTVGGNATRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1H9</accession>
    <name>B8M1H9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin C-terminal hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_091160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478838.1">
        <property type="nucleotide sequence ID" value="XM_002478793.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M1H9"/>
    <dbReference type="GeneID" id="8101605"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_091160"/>
    <dbReference type="eggNOG" id="KOG1866">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_228178_0_0_1"/>
    <dbReference type="InParanoid" id="B8M1H9"/>
    <dbReference type="OMA" id="FSAIQCE"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="PhylomeDB" id="B8M1H9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000136">
        <property type="entry name" value="Ubiquitin C-terminal hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021905">
        <property type="entry name" value="DUF3517"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF827">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12030">
        <property type="entry name" value="DUF3517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="1597"/>
            <end position="1925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2495"/>
            <end position="2521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED21875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="2521" mass="286848" checksum="EBBE215D85529E37" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1I0</accession>
    <name>B8M1I0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor TFIIE complex alpha subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_091170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478839.1">
        <property type="nucleotide sequence ID" value="XM_002478794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1I0"/>
    <dbReference type="FunCoup" id="B8M1I0">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M1I0"/>
    <dbReference type="GeneID" id="8101606"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_091170"/>
    <dbReference type="eggNOG" id="KOG2593">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035744_1_0_1"/>
    <dbReference type="InParanoid" id="B8M1I0"/>
    <dbReference type="OMA" id="DAIKWKV"/>
    <dbReference type="OrthoDB" id="361102at2759"/>
    <dbReference type="PhylomeDB" id="B8M1I0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="333"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="403"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED21876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="448" mass="48705" checksum="7553175267A3178E" modified="2009-03-03" version="1">MDLASALVRSVVRAFYETRQILVVDALFTHSVLHAEDLAHLLGMQQKDLRKLCARLREDRLIAVHTRSEIREGSTRPVNRDYYYIPLHPVIDAIKYRVLRLTSSIKAQYTPSEDRKEYICLRCGAEWTELDVLSLYSDEGFECQSCGAILERTEDVKGTEGLDRTGHEKNSKLMAQLEAFTSLLKQIDATEIPVNDFETAWDHKVEVIRNQQTHPSKPAIAAAAKQPAAVRGNQRVDAAAIEVSLQSSAEKTAAEQAADAARKAAFEKQNALPVWHTHSTVSTTAGNINKIKAETDAEIRAEIKDEAGAADETKPSTDALDDIAAYYAEIAKAKAEEATSPDEDDSDDDEDEDEFEDISVVGTPATTTVASGGGGGPTSAPVPGRSSAGIKRELESESGGSSAPQTATGTPGTPADDGPVSKKVKTEEDVIKKEEESDEDEEEFEDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1R5</accession>
    <name>B8M1R5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine acid phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_093980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479115.1">
        <property type="nucleotide sequence ID" value="XM_002479070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1R5"/>
    <dbReference type="GeneID" id="8103726"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_093980"/>
    <dbReference type="eggNOG" id="KOG3672">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030126_0_0_1"/>
    <dbReference type="InParanoid" id="B8M1R5"/>
    <dbReference type="OMA" id="DWEWNYY"/>
    <dbReference type="OrthoDB" id="10262962at2759"/>
    <dbReference type="PhylomeDB" id="B8M1R5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF195">
        <property type="entry name" value="ACID PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877234" evidence="2">
        <location>
            <begin position="21"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED22152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="468" mass="51902" checksum="217048117D33CE8F" modified="2009-03-03" version="1">MSRFSVGIAIGLASLSPVLGLTPEETFYPPTLNDTAYISNSSIGTYGGTYQAPTTGPTGGTPYGAYDYCSMPHPRPQEYELPDALKQGHVWGKLVYLEYLQRHQRRSPYNILPGGENQAYECDNVRPYLYAGVNSFSGIQPIPMYAQTYQDPTNPFTPGVNGTCQYPQITIGGIQDGFQHGKDLWAVYGERLGLIPRQPNERVWFRSSESALTQGSAGAVLRGVWPWYQGTLPLHQMVSSVDTVNAGYSCSAVGNMLNAIKSTPEWNEHITVTAELRSTLGSMLGAESGSWQSTFDHFSDNFQARLCNGYMLPCSLTNSSNCVTMEMAEEVFRAGDWEWNYYWRTNPDVAKYIQVVEGLFIGEIVTHLQAVLNGTSSLDYTHIFVHDGDIGPVLGALGIDALRWPAMASNIAFEVWETNDNQSRYYARVLYSGWPLKTIHGTLDWVPLADLINIMKPYIPKDIVSLCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1U1</accession>
    <name>B8M1U1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_085500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478282.1">
        <property type="nucleotide sequence ID" value="XM_002478237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1U1"/>
    <dbReference type="STRING" id="441959.B8M1U1"/>
    <dbReference type="GeneID" id="8104515"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_085500"/>
    <dbReference type="HOGENOM" id="CLU_2544152_0_0_1"/>
    <dbReference type="InParanoid" id="B8M1U1"/>
    <dbReference type="OrthoDB" id="5106062at2759"/>
    <dbReference type="PhylomeDB" id="B8M1U1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED21319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="83" mass="9491" checksum="2D425FAF881A4393" modified="2009-03-03" version="1">MEMPPFRSTPIAGFTRTQPVLSWAFPTLFPRGEAEFILPRQHSVKFDDYIKHLMRFDNGPGGQEVTADQLRAAFEDDNPEGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2W8</accession>
    <name>B8M2W8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein SSH4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein ssh4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSTA_094690</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SSH4 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479186.1">
        <property type="nucleotide sequence ID" value="XM_002479141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2W8"/>
    <dbReference type="FunCoup" id="B8M2W8">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M2W8"/>
    <dbReference type="GeneID" id="8103799"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_094690"/>
    <dbReference type="eggNOG" id="KOG1477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016552_1_1_1"/>
    <dbReference type="InParanoid" id="B8M2W8"/>
    <dbReference type="OMA" id="FFFKYTR"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="PhylomeDB" id="B8M2W8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000065">
        <property type="entry name" value="Ear1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="18">
        <location>
            <begin position="128"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="434"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EED22223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="487" mass="53082" checksum="613A6213717CC69D" modified="2009-03-03" version="1">MPPPDPVLLTPAMASPTGFTTSLRIHSQTEFKIAESTQQPMYTGVSSNSDIMAEIAAVSGSTGKGILIGILSALGSAGVAIVVLTIILFFKYTRRGRILLDRIGRPGEFDDEEAFAREEAEALETMDDLSRTEYLRAKAFIQANPPETMQTDISLSQFLAIQEKGVSAWQFEPELEIANCFVEARTEIEFFDSECSVQTNLPVPKQNEVYYWEAKIYDKPESTLISIGMTTKPYPLFRLPGFHKTSVAYQSTGERRYNQPFKSPSYGPEYNQGDVIGVGYRPRSGTIFFTRNGKKLEDVVHGLKSPNFFPTVGANGPCTIHVNFGQMGFVFIEANVKKWGLAPMTGSLAPPPPYGSEQGSILLESGRETTAPVAPSYLEAGYRGSRSTVPTSPGPIRSPTDISLAQLAHIPSHEDFGEGSSRNTVNTAEDGLYITAASPPPEYSSPESSRNSFRSDHEGGDASHPPGYTAVAADEGNQQHHSHHDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8M331</accession>
    <name>B8M331_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRP9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_092500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478970.1">
        <property type="nucleotide sequence ID" value="XM_002478925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M331"/>
    <dbReference type="STRING" id="441959.B8M331"/>
    <dbReference type="GeneID" id="8099431"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_092500"/>
    <dbReference type="eggNOG" id="ENOG502SD1I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096859_0_0_1"/>
    <dbReference type="InParanoid" id="B8M331"/>
    <dbReference type="OMA" id="YETNKGA"/>
    <dbReference type="OrthoDB" id="5419752at2759"/>
    <dbReference type="PhylomeDB" id="B8M331"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039914">
        <property type="entry name" value="SRP9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039432">
        <property type="entry name" value="SRP9_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834:SF12">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05486">
        <property type="entry name" value="SRP9-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP9" evidence="2">
        <location>
            <begin position="5"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED22007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="166" mass="17228" checksum="2F8689C95A66E69F" modified="2009-03-03" version="1">MPYLPTPNAFLEQSSLLLEAYPDDTRITTKYSYPNPSNKNNTHKISKRQSSKTTPNTEESIIPKSTTTTCATLTLKTYNPVTGICLKYKTNKAAEVGRLISGLGKLGAGVKITSATEEPVATTAAAATEGESSEVPVQIQAAPAVAAPSSGGGGGGGKKKKGKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8M405</accession>
    <name>B8M405_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CoA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_039470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481182.1">
        <property type="nucleotide sequence ID" value="XM_002481137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M405"/>
    <dbReference type="STRING" id="441959.B8M405"/>
    <dbReference type="GeneID" id="8109285"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_039470"/>
    <dbReference type="eggNOG" id="ENOG502S3ZG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112567_1_1_1"/>
    <dbReference type="InParanoid" id="B8M405"/>
    <dbReference type="OMA" id="IYNACVL"/>
    <dbReference type="OrthoDB" id="5138418at2759"/>
    <dbReference type="PhylomeDB" id="B8M405"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303:SF2">
        <property type="entry name" value="COA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303">
        <property type="entry name" value="CYTOPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA-binding" evidence="1">
        <location>
            <begin position="40"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="182" mass="20220" checksum="087FF9972C8CE6BB" modified="2009-03-03" version="1">MHSGHITRFLSHSFRSQSTSGNRFLRMTEAAVTRFFQSPQFAVAGANNDPSRFGYRIFAWYHQHSLPVTPIHPREQTIRLPSREYSVASSPKSLTQPTETSLSFVTPPPVTIQLLKEAHEIGIPAVWFQPGTYNDEVLDYARSNFEAVIGGPGGAGSEGWCVLVDGEDGLESAGRTWKQQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4R4</accession>
    <name>B8M4R4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposon, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_025750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479693.1">
        <property type="nucleotide sequence ID" value="XM_002479648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4R4"/>
    <dbReference type="GeneID" id="8107987"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_025750"/>
    <dbReference type="eggNOG" id="KOG3105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_14_1_1"/>
    <dbReference type="InParanoid" id="B8M4R4"/>
    <dbReference type="OrthoDB" id="4230268at2759"/>
    <dbReference type="PhylomeDB" id="B8M4R4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="30"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="498" mass="57548" checksum="BA7756348AA18A81" modified="2009-03-03" version="1">MRTSVIVAREFNVPYRRLLARVNGQTALQERPTQNNILTNDQECAVKAWIDNVDLMGIPPTNRMIISCANAILQDANPHVQPPPTVGTGWVYRFTKRIGYTRVKQKIIDPKRLEAEDLGVIQTWFDRLEIQLRINKITPSKLWNFDETGFQVGQGKNESIVTQFPRTSTRIASASSRESLTIIESVSAAGKVIPPLIILKGKHHMEEWYQNLFEDDYCVAYSEKGYSNAELTYEWLHHFDLSTQEYAKNGYRMLLMDNFKAHLTYEFIEHCRKQKIIIYCFPPHTTHFLQPLDDIPFQAYKHFHGIEVNKQMRAGAYDFDKYDFLYHLATVRNQTFTSRIIRAGFRDVGIHPYNPELVMDKLNAAEILDAVPILEIYDGEEQAIPSSPTTRSTSPPLDSYKIGRHIKKIEQDLELIKEGIKHISPNLERRVRRIMKGSLINAQISASHRRQVNHLLDVNRRKSKAKTRRQILNVGGVLTVRDANTKIEARKVLEIEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5W2</accession>
    <name>B8M5W2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_033350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480523.1">
        <property type="nucleotide sequence ID" value="XM_002480478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5W2"/>
    <dbReference type="GeneID" id="8105073"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_033350"/>
    <dbReference type="HOGENOM" id="CLU_1673533_0_0_1"/>
    <dbReference type="InParanoid" id="B8M5W2"/>
    <dbReference type="PhylomeDB" id="B8M5W2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="92"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="158" mass="18168" checksum="030AFFBC73D6BA72" modified="2009-03-03" version="1" fragment="single">ERNIPSSPTTGSRSPPRDTLAFEKDVKRLRRDIAAISDFFDQISPFLSRRVNRIVDAGLSKAHQSDLYEHHIELLTEIGGVLTVNDTNPAIENRKLDEMEKNKRRIERERERAREREAREMAQQQSLQAIQEPIDESAVSYLPDSSLLFIDIEGEARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6U5</accession>
    <name>B8M6U5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_034040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480599.1">
        <property type="nucleotide sequence ID" value="XM_002480554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6U5"/>
    <dbReference type="STRING" id="441959.B8M6U5"/>
    <dbReference type="GeneID" id="8097821"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_034040"/>
    <dbReference type="eggNOG" id="ENOG502RY95">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008869_0_0_1"/>
    <dbReference type="InParanoid" id="B8M6U5"/>
    <dbReference type="OMA" id="HVVHSKI"/>
    <dbReference type="OrthoDB" id="3248508at2759"/>
    <dbReference type="PhylomeDB" id="B8M6U5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF3">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="673" mass="75387" checksum="7AB9305C67A91D9F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6V3</accession>
    <name>B8M6V3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell surface protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_034130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480607.1">
        <property type="nucleotide sequence ID" value="XM_002480562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6V3"/>
    <dbReference type="STRING" id="441959.B8M6V3"/>
    <dbReference type="GeneID" id="8097829"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_034130"/>
    <dbReference type="eggNOG" id="ENOG502S5EQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037529_0_0_1"/>
    <dbReference type="InParanoid" id="B8M6V3"/>
    <dbReference type="OMA" id="DSHMANK"/>
    <dbReference type="OrthoDB" id="2590867at2759"/>
    <dbReference type="PhylomeDB" id="B8M6V3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39606:SF1">
        <property type="entry name" value="CELL SURFACE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39606">
        <property type="entry name" value="SURFACE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="46132" checksum="D6DAB58780B46946" modified="2009-03-03" version="1">MSSIINKVKDAVTHDKHEKPSYSTNAGPHDSNMANKVDPRVDSDRDGRAAYGTTGTTGTTGTGMNIGNTYTHGTTGSTNAGPHNSNVANKVDPRVDSDLDGRAVHGNTGYSGTHTGAGVGNTYGTTGSTNAGPHNSNVLNKVDPRVDSDLDGRATHHNTGYNTAGTTTGAVAGGYGTGSTNAGPHNSNMMNKLDPRVDSDRGKHLQKLVVVTAANSFSDGRNAFGSAGSADTTTKSFEQSQNESTATSTTAHGAHSSNHGPHNSNLMNKLDPRVDSDRDHHAAHSGMTGHSGTTGTTMGAGAGGMGAGAGGTTTYGHHGYGTTTAGPHDSNLANKMDPRVDSDRSNYGTTTTGHGYNTRSTNAGPHDTNMANKMDPRVDSDMDNRARHHHMGTTTGAAPAGSSYASTGTGQTYGSAGPHNSNLMNKLDPRIDSDLDGSRTVGNTQRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7I3</accession>
    <name>B8M7I3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-binding cassette transporter, putative</fullName>
            <ecNumber evidence="12">3.6.3.44</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_028250</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.44" evidence="12"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479970.1">
        <property type="nucleotide sequence ID" value="XM_002479925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7I3"/>
    <dbReference type="STRING" id="441959.B8M7I3"/>
    <dbReference type="GeneID" id="8108341"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_028250"/>
    <dbReference type="eggNOG" id="KOG0056">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_1_1"/>
    <dbReference type="InParanoid" id="B8M7I3"/>
    <dbReference type="OMA" id="DAYMAFI"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="PhylomeDB" id="B8M7I3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18583">
        <property type="entry name" value="ABC_6TM_HMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000287">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF651">
        <property type="entry name" value="HEAVY METAL TOLERANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
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            <end position="39"/>
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            <begin position="226"/>
            <end position="247"/>
        </location>
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            <begin position="342"/>
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        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
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            <begin position="229"/>
            <end position="511"/>
        </location>
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            <begin position="545"/>
            <end position="779"/>
        </location>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED19536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="806" mass="89298" checksum="9B401665D24CA3A6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7Q4</accession>
    <name>B8M7Q4_TALSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">TSTA_028890</name>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480041.1">
        <property type="nucleotide sequence ID" value="XM_002479996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7Q4"/>
    <dbReference type="STRING" id="441959.B8M7Q4"/>
    <dbReference type="GeneID" id="8099008"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_028890"/>
    <dbReference type="eggNOG" id="ENOG502QPW5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049926_0_0_1"/>
    <dbReference type="InParanoid" id="B8M7Q4"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="PhylomeDB" id="B8M7Q4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="415" mass="46197" checksum="56C8673BB3871C65" modified="2009-03-03" version="1">MLSSNGTMGRIPCYLPDILGVQPNVNTKCVGFAVTKADHLCGQQASDLSGRAQASRLLNEGTHLLQAGEENIDDLLRKLAPLLLCNRHHQKDAPRLVGEWSVKVAQFNRRRFALLRPSPSPNETEDTQDYRDLRLVHTPNRASHSEEAPQTPVEETDDIEWSDRIRSTRGTSAPPRFAPPEQLSTSTDTIATTAPAMGQRGSHTPLVVSVSVGSPTSTGHAIENISALSSALTGSLDDNHYVRARVDIYPQIASEGRSRMRQSHYVTVGFPSQVQNTESTTLTYQSRTQSFSWEGTESQPLNNRASRNTTAESTHQHRSRGATSASTSQELARRPTSSRSEVTRKRVEGDCHICFLPLQDEGSDDEDEEAKLERQQSEKDDEYDSEHDGESSEEDEELAYYDEYVTKLHMFKCKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8M862</accession>
    <name>B8M862_TALSN</name>
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        <submittedName>
            <fullName evidence="11">MFS sugar transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_032770</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002480413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M862"/>
    <dbReference type="GeneID" id="8105016"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_032770"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="InParanoid" id="B8M862"/>
    <dbReference type="OMA" id="KFWIIWA"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="PhylomeDB" id="B8M862"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF26">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="17"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="505"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED20024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="532" mass="59080" checksum="A6DC7AD30D27B1B5" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8G4</accession>
    <name>B8M8G4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_036980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480911.1">
        <property type="nucleotide sequence ID" value="XM_002480866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8G4"/>
    <dbReference type="STRING" id="441959.B8M8G4"/>
    <dbReference type="GeneID" id="8100544"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_036980"/>
    <dbReference type="eggNOG" id="KOG1203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025711_1_0_1"/>
    <dbReference type="InParanoid" id="B8M8G4"/>
    <dbReference type="OMA" id="DYVAWSA"/>
    <dbReference type="OrthoDB" id="10254604at2759"/>
    <dbReference type="PhylomeDB" id="B8M8G4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF50">
        <property type="entry name" value="UPF0659 PROTEIN YMR090W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="8"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED20477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="272" mass="29869" checksum="6804CA819C1A8B22" modified="2009-03-03" version="1">MPQVLLLGGHGKIALHLTPLLLARSWNVTSVIRNAEHEAEILALGKDKPGKLSVLLSSLDDVKSQADAQAVLDKVKPEYVVWAAGAGGKGGPQRTYAIDRDAAKHFIASSFATPSVTKFLLISHMGSRKTKPSWFTEESWKRTEKLWTDILPDYCKAKWEADQYQTALAAVTKTKNPEREIQSISLRPGLLTDELATGKVAMGHVKAAEGSVTREDVAVVADRLLARDDAEGWFDLLNGEEPIDEAVERVVKGKIDSIGDEDVENMIRKFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8H5</accession>
    <name>B8M8H5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_037090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480922.1">
        <property type="nucleotide sequence ID" value="XM_002480877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8H5"/>
    <dbReference type="STRING" id="441959.B8M8H5"/>
    <dbReference type="GeneID" id="8100555"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_037090"/>
    <dbReference type="HOGENOM" id="CLU_2279354_0_0_1"/>
    <dbReference type="InParanoid" id="B8M8H5"/>
    <dbReference type="OrthoDB" id="5084510at2759"/>
    <dbReference type="PhylomeDB" id="B8M8H5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED20488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="102" mass="11679" checksum="178BDAF958CFC367" modified="2009-03-03" version="1">MAAMHVSDRPPFVKFSESIPVNVIGRHGRMRSIKKPFKAWAKKIAELRREAEDGPEDCRPLTFFSPVCQENSHFTLLEINDTQLPLFKAIVLVIHFTQDSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8Q9</accession>
    <name>B8M8Q9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">GAR transformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_037860</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6R)-10-formyltetrahydrofolate = N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6S)-5,6,7,8-tetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GART family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481006.1">
        <property type="nucleotide sequence ID" value="XM_002480961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8Q9"/>
    <dbReference type="FunCoup" id="B8M8Q9">
        <property type="interactions" value="213"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M8Q9"/>
    <dbReference type="GeneID" id="8102162"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_037860"/>
    <dbReference type="eggNOG" id="KOG3076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038395_0_1_1"/>
    <dbReference type="InParanoid" id="B8M8Q9"/>
    <dbReference type="OMA" id="HYVDEGM"/>
    <dbReference type="OrthoDB" id="5575075at2759"/>
    <dbReference type="PhylomeDB" id="B8M8Q9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.170:FF:000009">
        <property type="entry name" value="Phosphoribosylglycinamide formyltransferase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369:SF2">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="10">
        <location>
            <begin position="7"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED20572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="224" mass="24524" checksum="3F80F55E2B15C289" modified="2009-03-03" version="1">MTDTPIRLTVLISGNGSNLQAVIDEIAKPTDSKLPNTQIVRVLSNRKTAYGLERATKAGIPTTYHNLLKYKKAHPATPEGVQLAREEYDEELARLVIADKPDLVACLGFMHVLSTRFLVPLEEEGIRIVNLHPALPGAFNGVDAIERAHAAWLEGTITKSGVMIHNVISEVDMGQPILVKEIPFVKGVDEDLGKFKEKVHSIEWGAVIEGLQMTIGEVRAKCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8R8</accession>
    <name>B8M8R8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_037950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481015.1">
        <property type="nucleotide sequence ID" value="XM_002480970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8R8"/>
    <dbReference type="STRING" id="441959.B8M8R8"/>
    <dbReference type="GeneID" id="8102171"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_037950"/>
    <dbReference type="eggNOG" id="ENOG502S47U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064532_0_0_1"/>
    <dbReference type="InParanoid" id="B8M8R8"/>
    <dbReference type="OMA" id="YSIHVMA"/>
    <dbReference type="OrthoDB" id="4159154at2759"/>
    <dbReference type="PhylomeDB" id="B8M8R8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF7">
        <property type="entry name" value="SUR7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="27348" checksum="62B8D52EBAC37AC5" modified="2009-03-03" version="1">MIFTLNTISKVFALVSFTLSTLCLFAGSQKSILQNASVVLLDTSASEPTSAIQAAANRTAADLGLKDFYAIHVLTYCEGNFKSSVEGGLEVTSCSKRRAPFAFDPAKVFSAGFKAGFNISDINWPDSITDDFEVMEMTTKAMSVLYVIGVASTGVVFLMEILLTQAGGKPSMFAHLFFVVLSFVCLGVSSSVASGIAVQFVNLINRHGQGFGVVAKGGSSFLGMTWSAVVLSFLTVVISVITLPSSGGTPISEKEIEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8X9</accession>
    <name>B8M8X9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nuclear pore protein (SEH1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_038480</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481076.1">
        <property type="nucleotide sequence ID" value="XM_002481031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8X9"/>
    <dbReference type="FunCoup" id="B8M8X9">
        <property type="interactions" value="1187"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M8X9"/>
    <dbReference type="GeneID" id="8107890"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_038480"/>
    <dbReference type="eggNOG" id="KOG2445">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032441_5_0_1"/>
    <dbReference type="InParanoid" id="B8M8X9"/>
    <dbReference type="OMA" id="WFRLWAE"/>
    <dbReference type="OrthoDB" id="5566198at2759"/>
    <dbReference type="PhylomeDB" id="B8M8X9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF3">
        <property type="entry name" value="NUCLEOPORIN SEH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="9"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="328"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED20642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="382" mass="43040" checksum="2345BC82C673CB19" modified="2009-03-03" version="1">MGTNFTDFESGHRDLVTVTKFNFYGNRIVTGSSDHRLKVWDQKDGQWQLTDTWRAHDAEIRDATWNGPFTGQHIGSVGEDMRLKIWQEDVTQPPNSGRRFKSIYRLPAPHRVPFVSLDFRNVDLDTWLAVITRDGYLMVMEPVMPDTLGEWQALDQFRVCTAPGRGEETSFRVQFHHDSFDATHSLKPDGDRKSLSLVVAAMDTVKIYRTDSSRRFYHAIELTGHGGLVRDISWANGSVRGYDLIASGCKDGFIRIFEVYTSLSGNGAHGNHHHQRNGHLSAQSPSQRATAQSGIGSALANRAPVTASPRPANVDTPFRHEYREVACIDSRHLDVWQVQWSFAGDCLISSGDDGSVRFWKKGLTGEWLEFAETDMTDEEPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8M975</accession>
    <name>B8M975_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_112060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481362.1">
        <property type="nucleotide sequence ID" value="XM_002481317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M975"/>
    <dbReference type="STRING" id="441959.B8M975"/>
    <dbReference type="GeneID" id="8098861"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_112060"/>
    <dbReference type="HOGENOM" id="CLU_043971_0_0_1"/>
    <dbReference type="InParanoid" id="B8M975"/>
    <dbReference type="OrthoDB" id="3469466at2759"/>
    <dbReference type="PhylomeDB" id="B8M975"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="41308" checksum="3EFD1BAC73496D2C" modified="2009-03-03" version="1">MQLYDYLAQIYVFIQNPVRRTGFGLLYYCLPFIVSSAAVLNALLSVVATHRILISGRGNERHKSDLVAAYYHHKVQTIQIVNESLARQPNNITFDVQVAIAILGIVEYTTGSLDNAQKHMAGLQVIMDANGGTIGAPPDHYSALGIVKIANMLISNDQHDHPMNNERRMLDGILTKLPGDCHPSIPSMFHSLKHLSTTMPRNPAVTIAQQSSWLDQLNITELQMHQIIENELISQTDALTTPFVTSRVYPIAGSIFLCLWLRQLSIQSNVLDYLVDSLIYALDEIEHEQQYPSVILLWLLFVGGAAAEGRRTRQWFLGRLSNAVQTLNLDSWRRVKNVLEALPYVDECDEYLRRIWEELERSTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8M998</accession>
    <name>B8M998_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha-L-rhamnosidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_114670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481650.1">
        <property type="nucleotide sequence ID" value="XM_002481605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M998"/>
    <dbReference type="STRING" id="441959.B8M998"/>
    <dbReference type="GeneID" id="8109229"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_114670"/>
    <dbReference type="HOGENOM" id="CLU_1526166_0_0_1"/>
    <dbReference type="InParanoid" id="B8M998"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="PhylomeDB" id="B8M998"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF4">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="1">
        <location>
            <begin position="103"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="176" mass="19651" checksum="B8E12BA0ACFFE92C" modified="2009-03-03" version="1">MYINIWALGPRTEQFTYFAPGTQSATWDISKNGTYIRGQKPASTGEIVNLRNCTVKFEAMIDYGGTGWRMGTEINATQATGPIYQTHYWRGYSTALLTEYALGVRPVTVGYREFLFAPLPGFKVERVQGRVPTPHDLIYANWGYGSNSKIIMDIDIPKGTKATVVPPFSGPWTRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAB5</accession>
    <name>B8MAB5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_123490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482609.1">
        <property type="nucleotide sequence ID" value="XM_002482564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAB5"/>
    <dbReference type="STRING" id="441959.B8MAB5"/>
    <dbReference type="GeneID" id="8108260"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_123490"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_957055_0_0_1"/>
    <dbReference type="InParanoid" id="B8MAB5"/>
    <dbReference type="OMA" id="FDKWKRM"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="PhylomeDB" id="B8MAB5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF14">
        <property type="entry name" value="DEHYDROGENASE ARBD, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED18617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="291" mass="31482" checksum="34D6C5E660025EBE" modified="2009-03-03" version="1">MPGGVACSIIGYHISRHTENTDSRRTMVLFLNPFRNPRSARTGSNAALLSLCRPRMIARIARVTSLSQSQKCQFSLASSLCQNSQYTRPPKTLPGFSLEGQTCIVTGAARGLGKEFLTAFARSGANGACIDLSLPAATSSIEHITSQVKTSSQSKGINLKPYSCDVTSESQVQSTINQIIKDFGKIDVLVTAAGIVDNVPAEDYSYAKWRKLMDVNLDGSFLCAREVGRHMIQQKNGGSIILVGSMCGDVCVRPQKQAAYNASKAAVIMLAKSLATEYVSHYSTLKCRYTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAG6</accession>
    <name>B8MAG6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_112230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481382.1">
        <property type="nucleotide sequence ID" value="XM_002481337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAG6"/>
    <dbReference type="GeneID" id="8098878"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_112230"/>
    <dbReference type="eggNOG" id="ENOG502RN7F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060599_1_0_1"/>
    <dbReference type="InParanoid" id="B8MAG6"/>
    <dbReference type="OMA" id="QCNESEV"/>
    <dbReference type="OrthoDB" id="4186330at2759"/>
    <dbReference type="PhylomeDB" id="B8MAG6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="385" mass="42719" checksum="A8A922E56169BC37" modified="2009-03-03" version="1">MFENFSFPSPSSTAEGDDRLMLDCDSTTISPLSSRCPSPSSFLPRRSRPLSRPRSPFHRRPQQPPTSMPSNYEQFQRRISVSTLTEKLNAHTLDQNTTPGLSHAPHESPVSPISPTSFSFSVTKDSGSSRGSVRTLLTPPGEYDDEGYDDLLTSGWEPYHNAQSPTSIPLDSDGFLDVPQQRFPREQSLRSQRQQMSRAQCNVDVLKLALLAENFSSRTSESVGLSDDECHPSSLPPDTSPPSLRRPSIKPRCGSGASVAGNLRYRSRTSLNPEMVRRRSTSSAATFASSTRIAKPRARELLSKKSEQTLRRKSLVCATIASAMEKKKFILVISVPASLYKLKIILECIHHACQLRSHHSFQHTETGYPNTWECSPSLSSIVKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAS0</accession>
    <name>B8MAS0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_115570</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481753.1">
        <property type="nucleotide sequence ID" value="XM_002481708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAS0"/>
    <dbReference type="FunCoup" id="B8MAS0">
        <property type="interactions" value="657"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MAS0"/>
    <dbReference type="GeneID" id="8099584"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_115570"/>
    <dbReference type="eggNOG" id="KOG2085">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8MAS0"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="PhylomeDB" id="B8MAS0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070199">
        <property type="term" value="P:establishment of protein localization to chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031107">
        <property type="term" value="P:septin ring disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031134">
        <property type="term" value="P:sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000016">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="610"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="649"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="662"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="672"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED17761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="704" mass="79796" checksum="A04C3787AA3366A8" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MB16</accession>
    <name>B8MB16_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_124410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482709.1">
        <property type="nucleotide sequence ID" value="XM_002482664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MB16"/>
    <dbReference type="GeneID" id="8098392"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_124410"/>
    <dbReference type="eggNOG" id="ENOG502S3S2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082191_2_1_1"/>
    <dbReference type="InParanoid" id="B8MB16"/>
    <dbReference type="OrthoDB" id="3063476at2759"/>
    <dbReference type="PhylomeDB" id="B8MB16"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF1">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="92" mass="9879" checksum="C0EFF965AF688580" modified="2009-03-03" version="1">MSSGRAVSHGRGGAGNIHADGKATTAADLVTPTLKQDFFTTGRGGTGNMAHNDKDRPELARDYQDVEKPPKRSEENVQFTGRGKPAPLTWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBP1</accession>
    <name>B8MBP1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L8, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_119380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482166.1">
        <property type="nucleotide sequence ID" value="XM_002482121.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482167.1">
        <property type="nucleotide sequence ID" value="XM_002482122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBP1"/>
    <dbReference type="FunCoup" id="B8MBP1">
        <property type="interactions" value="1183"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MBP1"/>
    <dbReference type="GeneID" id="8104388"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119380"/>
    <dbReference type="eggNOG" id="KOG2309">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036235_0_3_1"/>
    <dbReference type="InParanoid" id="B8MBP1"/>
    <dbReference type="OMA" id="HPYKFKM"/>
    <dbReference type="OrthoDB" id="10267824at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000020">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000006">
        <property type="entry name" value="60S ribosomal protein L8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="5">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="4">
        <location>
            <begin position="96"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED18174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="254" mass="27475" checksum="6AE16692FA3C21C3" modified="2009-03-03" version="1">MGRVIRNQRKGRGSIFTAHTRLNKAPAQFRTLDYAERHGYVRGVVKEIIHDPGRGAPLAKVSFRHPYRFKKITETFIANEGMYTGQFIYAGKNASLTVGNVLPLGSVPEGTVVTNVEEKIGDRGALGRTSGNYVTVIGHNPEEGKTRVKLPSGAKKVVSSKARGMIGIVAGGGRTDKPLLKASRAKHKFAVKRNSWPKTRGVAMNPVDHPHGGGNHQHIGKASTISRYAAQGQKAGLIAARRTGLLRGTQKTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBP8</accession>
    <name>B8MBP8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Importin beta-5 subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_119430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482173.1">
        <property type="nucleotide sequence ID" value="XM_002482128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBP8"/>
    <dbReference type="FunCoup" id="B8MBP8">
        <property type="interactions" value="1080"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MBP8"/>
    <dbReference type="GeneID" id="8105218"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119430"/>
    <dbReference type="eggNOG" id="KOG2274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008920_1_1_1"/>
    <dbReference type="InParanoid" id="B8MBP8"/>
    <dbReference type="OMA" id="NPDQYTI"/>
    <dbReference type="OrthoDB" id="431626at2759"/>
    <dbReference type="PhylomeDB" id="B8MBP8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000373">
        <property type="entry name" value="Importin beta-5 subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056840">
        <property type="entry name" value="HEAT_IPO9_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF9">
        <property type="entry name" value="IMPORTIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25018">
        <property type="entry name" value="HEAT_IPO9_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="23"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED18181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1037" mass="113871" checksum="04D94341A0CBE77B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBR9</accession>
    <name>B8MBR9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="16">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSTA_119640</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Protein phosphatase that specifically binds to and dephosphorylates the molecular chaperone Hsp90. Dephosphorylation positively regulates the Hsp90 chaperone machinery.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:20630"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="16"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482194.1">
        <property type="nucleotide sequence ID" value="XM_002482149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBR9"/>
    <dbReference type="FunCoup" id="B8MBR9">
        <property type="interactions" value="618"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MBR9"/>
    <dbReference type="GeneID" id="8105239"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119640"/>
    <dbReference type="eggNOG" id="KOG0376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3870">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012645_0_0_1"/>
    <dbReference type="InParanoid" id="B8MBR9"/>
    <dbReference type="OMA" id="NDMAEAY"/>
    <dbReference type="OrthoDB" id="445564at2759"/>
    <dbReference type="PhylomeDB" id="B8MBR9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07417">
        <property type="entry name" value="MPP_PP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.60:FF:000002">
        <property type="entry name" value="Protein-glutamate O-methyltransferase C1393.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000389">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000039">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041753">
        <property type="entry name" value="PP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 15" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="17">
        <location>
            <begin position="279"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EED18202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="943" mass="106750" checksum="94EAAF910F9A1030" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBS9</accession>
    <name>B8MBS9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SNF2 family helicase/ATPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_119720</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482204.1">
        <property type="nucleotide sequence ID" value="XM_002482159.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MBS9"/>
    <dbReference type="GeneID" id="8105247"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119720"/>
    <dbReference type="eggNOG" id="KOG1015">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001161_0_0_1"/>
    <dbReference type="InParanoid" id="B8MBS9"/>
    <dbReference type="OMA" id="QCQSMEQ"/>
    <dbReference type="OrthoDB" id="2020972at2759"/>
    <dbReference type="PhylomeDB" id="B8MBS9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18007">
        <property type="entry name" value="DEXHc_ATRX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
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    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
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            <begin position="211"/>
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            <begin position="240"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="1788" mass="202243" checksum="6E1D46C30EE9482B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBT1</accession>
    <name>B8MBT1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Carbamoyl phosphate synthase arginine-specific small chain</fullName>
            <ecNumber evidence="4">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Arginine-specific carbamoyl phosphate synthetase, glutamine chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TSTA_119740</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Small subunit of the arginine-specific carbamoyl phosphate synthase (CPSase). CPSase catalyzes the formation of carbamoyl phosphate from the ammonia moiety of glutamine, carbonate, and phosphate donated by ATP, the first step of the arginine biosynthetic pathway. The small subunit (glutamine amidotransferase) binds and cleaves glutamine to supply the large subunit with the substrate ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CarA family.</text>
    </comment>
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        <property type="protein sequence ID" value="EED18214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482206.1">
        <property type="nucleotide sequence ID" value="XM_002482161.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482207.1">
        <property type="nucleotide sequence ID" value="XM_002482162.1"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_035901_1_0_1"/>
    <dbReference type="InParanoid" id="B8MBT1"/>
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    <dbReference type="OrthoDB" id="434at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:L-arginine biosynthetic process"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific small chain"/>
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    </dbReference>
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        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
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        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
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        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF4">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6 20" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbamoyl-phosphate synthase small subunit N-terminal" evidence="19">
        <location>
            <begin position="43"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="454"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EED18214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="468" mass="50781" checksum="B98D17CA2C9618FD" modified="2009-03-03" version="1">MFAQLFRSTTLRASPVSSVKASLPQMRSLATVDRRFASTRRFEPATFTIRNGPVFHGKSFGANTNISGEAVFTTSLVGYPESLTDPSYRGQILVFTQPLIGNYGVPSAEKDTNGLLKYFESPNLQAAGVVVADVAEQYSHWTAVESLGEWCAREGVPAISGVDTRAIVTFLREQGSSLARITVGEEYDADEDEAFIDPEQINLVRQVSTKAPFHVSAANPECHVALIDCGVKENILRSLVGRGASVTVFPFDYPIHKVAHHFDGVFISNGPGDPTHCQDTVYHLRKLMETSQVPIMGICLGHQLLALAAGARTIKLKYGNRAHNIPALDLTTGRCHITSQNHGYAVDASTLPSDWKPYFVNLNDSSNEGMIHKSRPIFSTQFHPEAKGGPLDSSYLFDIYLDSVAKYKKNQSVFQPTRESRPSPLLVDLLPKERVGVAPTTGALNNARTPTAPSPVSQQAPAAAVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBU4</accession>
    <name>B8MBU4_TALSN</name>
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        <submittedName>
            <fullName evidence="2">Peroxisomal membrane protein (Pex3), putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">TSTA_119820</name>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482219.1">
        <property type="nucleotide sequence ID" value="XM_002482174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBU4"/>
    <dbReference type="FunCoup" id="B8MBU4">
        <property type="interactions" value="181"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MBU4"/>
    <dbReference type="GeneID" id="8105257"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119820"/>
    <dbReference type="eggNOG" id="KOG4444">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017002_3_0_1"/>
    <dbReference type="InParanoid" id="B8MBU4"/>
    <dbReference type="OMA" id="HRGWKDL"/>
    <dbReference type="OrthoDB" id="45930at2759"/>
    <dbReference type="PhylomeDB" id="B8MBU4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006966">
        <property type="entry name" value="Peroxin-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080:SF1">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04882">
        <property type="entry name" value="Peroxin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="525" mass="58024" checksum="67D0E0D135385438" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MC95</accession>
    <name>B8MC95_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">RING finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_122720</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482533.1">
        <property type="nucleotide sequence ID" value="XM_002482488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MC95"/>
    <dbReference type="STRING" id="441959.B8MC95"/>
    <dbReference type="GeneID" id="8097737"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_122720"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008264_1_1_1"/>
    <dbReference type="InParanoid" id="B8MC95"/>
    <dbReference type="OMA" id="PGCSICT"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="PhylomeDB" id="B8MC95"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ATL42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ATL42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877416" evidence="11">
        <location>
            <begin position="32"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="370"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="306"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="421"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="487"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="422"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="513"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED18541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="529" mass="57477" checksum="659EB5F96A386A50" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCL5</accession>
    <name>B8MCL5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Multidrug resistance protein, putative</fullName>
            <ecNumber evidence="13">1.3.1.74</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_125450</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.74" evidence="13"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482823.1">
        <property type="nucleotide sequence ID" value="XM_002482778.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MCL5"/>
    <dbReference type="GeneID" id="8108377"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_125450"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_5_1"/>
    <dbReference type="InParanoid" id="B8MCL5"/>
    <dbReference type="OMA" id="KSIKMMG"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="PhylomeDB" id="B8MCL5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032440">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
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    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="486"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="851"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="892"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="964"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="991"/>
            <end position="1011"/>
        </location>
    </feature>
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        <location>
            <begin position="1075"/>
            <end position="1096"/>
        </location>
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        <location>
            <begin position="230"/>
            <end position="507"/>
        </location>
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        <location>
            <begin position="573"/>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED18831.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1402" mass="154035" checksum="B0A1E58B0606164F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCU9</accession>
    <name>B8MCU9_TALSN</name>
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        <recommendedName>
            <fullName evidence="4">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="5" type="ORF">TSTA_127090</name>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Trichocomaceae</taxon>
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        </lineage>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the D-alanine--D-alanine ligase family.</text>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Dala_Dala_lig_C"/>
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        <property type="entry name" value="D-ALANINE--D-ALANINE LIGASE"/>
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    </dbReference>
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        <property type="entry name" value="D-ALANINE--D-ALANINE LIGASE B"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="159"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED19001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="389" mass="42321" checksum="349A027BD227C932" modified="2009-03-03" version="1">MLIASNFIRSAAVRALHQVCSGSIPHRAISTQSPRVAVLFQAIDPPVIGNVRKPCKPGGYRDSGADIAYTLRIKGIESITPDISPKPSNDHGWCFADTEEGIQSALEKGATHLWANTILFKSHPLQSSQKLSSRVPDVYVVGQPPTLVEKFDDKAYLNGKLKELGGYTLPQSWLASNPATLEKCISSITKLPVVGKPVRGRGSHGVKLCHNPEELREHVLSLLQESPLVMIEEYLAGEEATITVMPPSSEMPDYWSLPPVTRFNHADGVAPYNGAVAVSANSRVVTESELRDLAYGKVINECVQVARLIRATAPIRIDARRFSEGSEFALFDINMKPNMTGPGRPGREDQASLTAIAASALGWDYGSLLMKILATAQPLSSLRLYRSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCW8</accession>
    <name>B8MCW8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BolA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_113200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002481441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCW8"/>
    <dbReference type="FunCoup" id="B8MCW8">
        <property type="interactions" value="295"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MCW8"/>
    <dbReference type="GeneID" id="8101632"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_113200"/>
    <dbReference type="eggNOG" id="KOG3348">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109462_1_0_1"/>
    <dbReference type="InParanoid" id="B8MCW8"/>
    <dbReference type="OMA" id="CHRMVNT"/>
    <dbReference type="OrthoDB" id="4983at2759"/>
    <dbReference type="PhylomeDB" id="B8MCW8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045115">
        <property type="entry name" value="BOL2"/>
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        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
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        <property type="entry name" value="BOLA-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735">
        <property type="entry name" value="BOLA-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="137" mass="15231" checksum="43D6591C6D8613E9" modified="2009-03-03" version="1">MFVRTTVSRGYRSLTRSTSRPFFNPVQTTTPFSRLPSRSFAVAMADSASTSGVTADGLKEKLSAQLGAQFVEIEDMSGGCGQAFQAIIVSPQFDKKNMLARHRLVNSVLKDEIAAIHAWTPKCYTPEQWQKLQEERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MD82</accession>
    <name>B8MD82_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spermine/spermidine synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_114200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481599.1">
        <property type="nucleotide sequence ID" value="XM_002481554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MD82"/>
    <dbReference type="STRING" id="441959.B8MD82"/>
    <dbReference type="GeneID" id="8109182"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_114200"/>
    <dbReference type="eggNOG" id="ENOG502QTVA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017511_2_0_1"/>
    <dbReference type="InParanoid" id="B8MD82"/>
    <dbReference type="OMA" id="CFIGWAG"/>
    <dbReference type="OrthoDB" id="2016285at2759"/>
    <dbReference type="PhylomeDB" id="B8MD82"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000288">
        <property type="entry name" value="Spermine/spermidine synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037959">
        <property type="entry name" value="MFS_SpdSyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317:SF1">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED17607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="588" mass="65687" checksum="9295725A39A9573C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDT0</accession>
    <name>B8MDT0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Laccase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_120560</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482301.1">
        <property type="nucleotide sequence ID" value="XM_002482256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MDT0"/>
    <dbReference type="SMR" id="B8MDT0"/>
    <dbReference type="STRING" id="441959.B8MDT0"/>
    <dbReference type="GeneID" id="8100040"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_120560"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_7_2_1"/>
    <dbReference type="InParanoid" id="B8MDT0"/>
    <dbReference type="OMA" id="HGHHFYI"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="PhylomeDB" id="B8MDT0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04206">
        <property type="entry name" value="CuRO_1_LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04205">
        <property type="entry name" value="CuRO_2_LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13910">
        <property type="entry name" value="CuRO_3_MCO_like_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF511">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="127"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="268"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="531"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED18309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="691" mass="77338" checksum="29A5268D8542F467" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8ME12</accession>
    <name>B8ME12_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_011980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483323.1">
        <property type="nucleotide sequence ID" value="XM_002483278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ME12"/>
    <dbReference type="STRING" id="441959.B8ME12"/>
    <dbReference type="GeneID" id="8104046"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_011980"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033341_0_0_1"/>
    <dbReference type="InParanoid" id="B8ME12"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="PhylomeDB" id="B8ME12"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43495">
        <property type="entry name" value="GABA PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43495:SF5">
        <property type="entry name" value="GAMMA-AMINOBUTYRIC ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="85"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="18"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED16089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="464" mass="51965" checksum="579926897C4B290D" modified="2009-03-03" version="1">MSSQNLFELFSWSHMDYGNGLNPGPEEQPQDGPEYRANRPGGSRLPEDFGRESDHPENLPWSLSRELGSIHIFVRYQLQVPTNETGHMLTLSSSFRLGGPSAAIYAYALLGVLATMVLHNIATMLRVWPVAGALLLYVKHFLDEEIGIVVTIVYWLTYCLTAAALTATIADLLAIFHLSDASTVVITVVVSVIPVALNYWSIRAFRHIEVGLGVFKLVVALVIILDMNILNAGTRSHILSVLTKTIKLIVYSSFQSNNPIARKAAGWFGGFMSSIFLGSFSIIGVEVVAVTAQEAIIYTRAEDNEETVTHEERQPRARSEEEFTDQFSWPARWTPIVVTLIYIWGVWSTMGNIPLEDLKMFYPNNNLAGSGHDPCKASIFIDTACPNPSGPGQSNDNLTHNQFGFYHHCSDLCFFENVKEQIRCTAKAIFVSAWLFWVPFLKFANAGTFNQVGYWNIRPFWLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B8ME64</accession>
    <name>B8ME64_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdenum cofactor sulfurase</fullName>
            <shortName evidence="4">MCS</shortName>
            <shortName evidence="4">MOS</shortName>
            <shortName evidence="4">MoCo sulfurase</shortName>
            <ecNumber evidence="4">2.8.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor sulfurtransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hxB</name>
        <name evidence="7" type="ORF">TSTA_015760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:42636"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:82685"/>
            <dbReference type="EC" id="2.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.9" evidence="4"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483725.1">
        <property type="nucleotide sequence ID" value="XM_002483680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ME64"/>
    <dbReference type="STRING" id="441959.B8ME64"/>
    <dbReference type="GeneID" id="8106349"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_015760"/>
    <dbReference type="eggNOG" id="KOG2142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010913_0_0_1"/>
    <dbReference type="InParanoid" id="B8ME64"/>
    <dbReference type="OMA" id="PCTRCQM"/>
    <dbReference type="OrthoDB" id="10264306at2759"/>
    <dbReference type="PhylomeDB" id="B8ME64"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008265">
        <property type="term" value="F:molybdenum cofactor sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03050">
        <property type="entry name" value="MOCOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028886">
        <property type="entry name" value="MoCo_sulfurase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF80">
        <property type="entry name" value="MOLYBDENUM COFACTOR SULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MOSC" evidence="6">
        <location>
            <begin position="625"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="632"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="632"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="662"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED16491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="864" mass="96037" checksum="4E6447333E22F5AB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEX8</accession>
    <name>B8MEX8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_023150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484495.1">
        <property type="nucleotide sequence ID" value="XM_002484450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEX8"/>
    <dbReference type="GeneID" id="8109967"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_023150"/>
    <dbReference type="eggNOG" id="ENOG502SVBM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128909_0_0_1"/>
    <dbReference type="InParanoid" id="B8MEX8"/>
    <dbReference type="OMA" id="TMGDKSP"/>
    <dbReference type="PhylomeDB" id="B8MEX8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="22386" checksum="FFE9A119AA00F3B7" modified="2009-03-03" version="1">MPQQAAAEQVKPRKLSQPCQRWQPSLQRSPTTFAEPFINWLDLQGLVLISDIDCPTHERGNVLDLSFASSPLALAGAKASIASHLDATSDHQPLITTVPWDQRYKETAQKLRFDTLDHTSFLSLLASNLAGTKSSAAAEEDLDALAEKLTSATQGAYRGSAKRTMTQGIGQPWWNEDCKKALHNYCLGLCSKTDFRRITRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8MF25</accession>
    <name>B8MF25_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_012330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483358.1">
        <property type="nucleotide sequence ID" value="XM_002483313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MF25"/>
    <dbReference type="STRING" id="441959.B8MF25"/>
    <dbReference type="GeneID" id="8104081"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_012330"/>
    <dbReference type="eggNOG" id="ENOG502T4YK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_700529_0_0_1"/>
    <dbReference type="InParanoid" id="B8MF25"/>
    <dbReference type="OrthoDB" id="42525at2759"/>
    <dbReference type="PhylomeDB" id="B8MF25"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009784">
        <property type="entry name" value="DUF1349"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332:SF2">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07081">
        <property type="entry name" value="DUF1349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED16124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="394" mass="44978" checksum="BA3F43D1CD6AE0A1" modified="2009-03-03" version="1">MAGRARKIRWATYLSSHYREDAPTVEVGILKSGLLWSQMYLNFWAKRLGKQIYFGLQVTEFLMKFVTGDTPENPASIMPELVEYLRFQKFHRVPYQEASYSVKLGRYVGDIGFMCPRCYRQNQASTAQRVRYAEFRDCTKYLSIAARRPRRQSQCPQKMVSHRDLIAVNHETQSHNLEILCPPKTDILYKPAIPDKARPFQFTAPIYKLSMPAGQFKRASVTITFNSNSFVEFDQAGLLFLRPHAKLPNPTSTNEGDAETSPGFVKIGPEVFQDRMRYAVSGSNHTIPDWSLWPVPDRFARTVTVSVEMVRHGPLLGAFVVERDGANVEKTLIRTVPWCFDDIADMDSEVWVGVYAARPDLDGASHGAPLQVRFSEFEIESTTGVLKFQDKWVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8MF50</accession>
    <name>B8MF50_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_012570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483383.1">
        <property type="nucleotide sequence ID" value="XM_002483338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MF50"/>
    <dbReference type="STRING" id="441959.B8MF50"/>
    <dbReference type="GeneID" id="8104105"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_012570"/>
    <dbReference type="HOGENOM" id="CLU_042074_0_0_1"/>
    <dbReference type="InParanoid" id="B8MF50"/>
    <dbReference type="OMA" id="PRIYAGW"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="PhylomeDB" id="B8MF50"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED16149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="461" mass="52812" checksum="776EE5D9FF1DE690" modified="2009-03-03" version="1">MEDCFGDSELSNRSPRVCLNCKARKRKCDKTLPACSRCDRLLLRCEYDSTDSIVADNDFSNISSSLRLISSVFGSWMSWVRNFYLSVQKMHLNSSENFVSTYLVTVHRWFPIIDEERFKDRLESHSYEYDINDFLLLTSIYLIVRRPDEQQRPAIMDDDPYQAVRHFYFHVFADLTSEPSIQFLQSGLLLATYEYGHGLVDAARNTLFSCLSASMLLGLHQTKAPLGVDSAWKRAMKDEATLICWAIVVTDRKLQLPVTKIIDEANLLSDLEVTENKSDGRLSWDHDAYTATSFYRQVQSSVLVGNVLDLILNATDPFSEECQRRFKVLDSQLQCAIHLTLQTETAGQLNSVSEALSLNRSAFFLLNWWQYEHSQKINNEAALLQSRMALESVIRITVETVSDFLPRIYAGWFNGVQCIFLAAVTAMQLDPTNSTRVEELKEMLGIQSLRWNSAAEYLRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFB8</accession>
    <name>B8MFB8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_017270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483886.1">
        <property type="nucleotide sequence ID" value="XM_002483841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFB8"/>
    <dbReference type="GeneID" id="8103700"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_017270"/>
    <dbReference type="HOGENOM" id="CLU_1797750_0_0_1"/>
    <dbReference type="InParanoid" id="B8MFB8"/>
    <dbReference type="PhylomeDB" id="B8MFB8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED16652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="144" mass="16378" checksum="268200EF628938A5" modified="2009-03-03" version="1">MEQVGPEDYLSGSVISSGVKSTGNSAPTPIGFIRNQIQEEWERGWKTSKNGSHLWRIDRNLPAVRTQRIPYDKNYGRRSGLHLTISRTCWEEDLKVSKRHHRDFKAGRRRAADRVPGMLATIGHDEALNSSLCNGLMYIDIDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFL1</accession>
    <name>B8MFL1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PHD finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_020580</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484235.1">
        <property type="nucleotide sequence ID" value="XM_002484190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFL1"/>
    <dbReference type="STRING" id="441959.B8MFL1"/>
    <dbReference type="GeneID" id="8102452"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_020580"/>
    <dbReference type="eggNOG" id="KOG0955">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002663_0_0_1"/>
    <dbReference type="InParanoid" id="B8MFL1"/>
    <dbReference type="OMA" id="NTSKWSH"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="PhylomeDB" id="B8MFL1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15670">
        <property type="entry name" value="ePHD_BRPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15492">
        <property type="entry name" value="PHD_BRPF_JADE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000008">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000007">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="406"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="460"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="62"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="153"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="372"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="624"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1028"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1103"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
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            <begin position="165"/>
            <end position="191"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <begin position="1045"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED17001.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1142" mass="127301" checksum="9814872C1832D54F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFR6</accession>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="52"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED17056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="499" mass="54920" checksum="2551622463042EE7" modified="2009-03-03" version="1">MERQPKMRGDIILVPQPSDDSADPLNWSQRKKYMTLGIVSLAAFTSHCAALANQQGISPQAKLYHKSLNDMADTVATAIAGMVAGPLVLVPLTHIFGCCSILLWSMVASTCGSIWSALMTKPNQYVAFTISRLSVGLFSATPTVLGPQMLVDIFFLHERGTVFNTFMVWSTFGVIIGPTLGGFIVAHAPWPWEFWWTVVLQGAVVLLAFVFLEETGFTRENGKVYPRRPSAFIHNRVATYFPGTQVAHVGGLQEALHSAWAQVLIGITPVTILVGIFLFGLSGWFVSFNTLLSVFLQNPVAAGGYGFSTQQNAAFTFTMWIGAAVAQFWGDFFNDRIPLYFVARNSGTWKPEYRLHSLWIPSFLVTPIALGIVGTTLKYHLHYIVLAGGAFLITFASVCTNPVAINYLVECFMNYPTEVNCILAVYRLSLGLGIPFFVRVWVANVGVGWVFGTMAILALILFIPIIILMLYGPTLRQMGFAKLRGDEEGAQVMRKDETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGD8</accession>
    <name>B8MGD8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_013580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002483447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGD8"/>
    <dbReference type="STRING" id="441959.B8MGD8"/>
    <dbReference type="GeneID" id="8099157"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_013580"/>
    <dbReference type="eggNOG" id="ENOG502QR0K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021595_0_0_1"/>
    <dbReference type="InParanoid" id="B8MGD8"/>
    <dbReference type="OMA" id="DWYNTEH"/>
    <dbReference type="OrthoDB" id="2851338at2759"/>
    <dbReference type="PhylomeDB" id="B8MGD8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43039">
        <property type="entry name" value="ESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="312"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED16258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="562" mass="63306" checksum="16AE8C217148B0F9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGE9</accession>
    <name>B8MGE9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_013690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483503.1">
        <property type="nucleotide sequence ID" value="XM_002483458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGE9"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Fungal_SecMet_Regulators"/>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="575"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED16269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="690" mass="77660" checksum="9A2E41EACE019DF8" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGL1</accession>
    <name>B8MGL1_TALSN</name>
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        <submittedName>
            <fullName evidence="3">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_018330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED16762.1"/>
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    <dbReference type="STRING" id="441959.B8MGL1"/>
    <dbReference type="GeneID" id="8100943"/>
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    <dbReference type="HOGENOM" id="CLU_018631_0_0_1"/>
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    <dbReference type="OMA" id="IDSYESW"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="PhylomeDB" id="B8MGL1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="F-box domain"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED16762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="594" mass="67140" checksum="40CAE6D20F672032" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHH9</accession>
    <name>B8MHH9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_010760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483194.1">
        <property type="nucleotide sequence ID" value="XM_002483149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHH9"/>
    <dbReference type="STRING" id="441959.B8MHH9"/>
    <dbReference type="GeneID" id="8109849"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_010760"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2110590_0_0_1"/>
    <dbReference type="InParanoid" id="B8MHH9"/>
    <dbReference type="OrthoDB" id="8069008at2759"/>
    <dbReference type="PhylomeDB" id="B8MHH9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="115" mass="12833" checksum="57B16606D2B20DE5" modified="2009-03-03" version="1">MQAADIPRSYKEAMATRWVIRGNIYNRHEHLFGDKSALAVTSSTKLILSAAAAHYGWFVAQTDAITVFSNGKLSQPVYMKQPTGFEQGERGVLVCRLRQALNGLEASARIWYNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHL7</accession>
    <name>B8MHL7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-chaperonin molecular chaperone ATPase</fullName>
            <ecNumber evidence="2">3.6.4.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_011120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="2"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483232.1">
        <property type="nucleotide sequence ID" value="XM_002483187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHL7"/>
    <dbReference type="FunCoup" id="B8MHL7">
        <property type="interactions" value="1522"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MHL7"/>
    <dbReference type="GeneID" id="8109885"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_011120"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8MHL7"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="PhylomeDB" id="B8MHL7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Heat shock protein 70"/>
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    </dbReference>
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        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Heat shock protein SSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Heat shock protein ssb1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase_NBD"/>
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        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
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        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
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        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED15998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="614" mass="67031" checksum="800143154C40A4A6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHR0</accession>
    <name>B8MHR0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_014820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EED16390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002483579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHR0"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022195_1_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:iron ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF9">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED16390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="449" mass="51855" checksum="7482B1051315735E" modified="2009-03-03" version="1">MDVLSKTFYDQLVQLGSQREEITPIIKERATDFIKSLTIWQILALVSCLYWALTSFAARTEDGYLKEWGDQWAMNTLWSHSEVPIKAISENRNDQMGKYLEAVRKELDYALEMEVPDAEDWISIDVQLMIQKLLARLVGKMIVGKPACRSPEWMDLAEHFTEDFITASIIMRLVPKWMHPLLTEVIPQRRRLRKRLQGVFNITDPCVARHEEAKMKRKQGLEIEEEDNMVAWILDNIKDQDYVLKNLNKLVVVMLVPAAHTKSPTLHEEILQVNKEHGEIGEKLPMKEWVTKLELLDSFFNGSQRLSQPLAITPNRYAVEDITFKDSLQVPKGALLGWVSIHNQIDSNIAPEPEKFDPMRSYGKRQVAAEECHKHLAGQPSLENLTFGYGSQACPGRNIAISILKMVVSRLLRDYEFKFADDQSKPKNIYLLEFIIPDPKARLMIRKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHX4</accession>
    <name>B8MHX4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Oligosaccharyltransferase subunit ribophorin II, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_015410</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483688.1">
        <property type="nucleotide sequence ID" value="XM_002483643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHX4"/>
    <dbReference type="FunCoup" id="B8MHX4">
        <property type="interactions" value="151"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MHX4"/>
    <dbReference type="GeneID" id="8106283"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_015410"/>
    <dbReference type="eggNOG" id="KOG2447">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051361_0_0_1"/>
    <dbReference type="InParanoid" id="B8MHX4"/>
    <dbReference type="OMA" id="VFFMYYT"/>
    <dbReference type="OrthoDB" id="432292at2759"/>
    <dbReference type="PhylomeDB" id="B8MHX4"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056790">
        <property type="entry name" value="Ribophorin_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008814">
        <property type="entry name" value="Swp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640">
        <property type="entry name" value="RIBOPHORIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25147">
        <property type="entry name" value="Ribophorin_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044234093" evidence="8">
        <location>
            <begin position="21"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II C-terminal" evidence="9">
        <location>
            <begin position="176"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED16454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="284" mass="30648" checksum="DA177AB6CF8BD58F" modified="2009-03-03" version="1">MRLLPAHLSLLALVAPSVYAASWGFTDATVSVSSKSATGKVKQSLKENAPVSTPISLGDSDSLRVLLTAQEDRSAKRPHQAFLLLKDSSTGLDVSYPFSVKNDGKSKVELSKKDIPTQFLATPNPVDAEIVIGSFGASDAYRNLAFQLSINSDASAPAAPDSVERYGKQPRINHIFKADPKSPPPIITLIFLLATLVTIPVLAGMWMYFDVNLYHLSIALKAAPVPHIVFVASIIGLEGIFFMYYTSWTLFQMLPATLAVGAIAFLSGSRALSEVQERRLAGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIA0</accession>
    <name>B8MIA0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_040640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484537.1">
        <property type="nucleotide sequence ID" value="XM_002484492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIA0"/>
    <dbReference type="GeneID" id="8110021"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_040640"/>
    <dbReference type="eggNOG" id="ENOG502SXT7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_811761_0_0_1"/>
    <dbReference type="InParanoid" id="B8MIA0"/>
    <dbReference type="OrthoDB" id="2687452at2759"/>
    <dbReference type="PhylomeDB" id="B8MIA0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="274"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED14584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="352" mass="38355" checksum="66DD2D6290F6C813" modified="2009-03-03" version="1">MDYSNSNIGADSTFQRQQNGSDFDDYESPNEIHSHQPYIELPSSQSKYPSPAVGSMGFALPESNGGLGIMNRDMNTGIGMGMGMTMNMDLRFHTNTSMNMTPGTHSLYCENGGTVPFHVQPNLTSSHAVMRCDAQSLLAVGHAVDTNAFMAVGTTSAPATRPIPIPLPNHSFHSASQFTMTPEFNSSSYEYSSSPYYYSASPATSSSSTSIHSEEYNHKVVRNVDASQLAAKSPSPGSPISTSCPAVLDSKSSTPSSPNPPVQLVQKKKSPASFECQKCGRFFTRGADVKRHETSVHSPRPMDCPVKNCVRKGSIGFPRRDHLMEHLRTFHNQNIPKRCGTKKRRTNAALDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIF8</accession>
    <name>B8MIF8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Epoxide hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_041200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484595.1">
        <property type="nucleotide sequence ID" value="XM_002484550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIF8"/>
    <dbReference type="STRING" id="441959.B8MIF8"/>
    <dbReference type="ESTHER" id="talsn-b8mif8">
        <property type="family name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="8109705"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_041200"/>
    <dbReference type="eggNOG" id="KOG4178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_7_0_1"/>
    <dbReference type="InParanoid" id="B8MIF8"/>
    <dbReference type="OMA" id="ATRWYRM"/>
    <dbReference type="OrthoDB" id="284184at2759"/>
    <dbReference type="PhylomeDB" id="B8MIF8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="34"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED14642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="329" mass="36750" checksum="3A57DCD80E6CD8BC" modified="2009-03-03" version="1">MALHLFPEISKTTTVRDGTKYSYIHVPPSDSNKPTFLLLHGFPSTSYDWRHVLPLLKDRGYGVIAPDLLGYGDSDNPAEVEAYSIKRMADHVIEVILSEGLEQVIGVGHDWGSTLLSTAALTYPDRFSGLTFTAVGFVPPEPFDLKSVNTMVKEYIGYPAFAYMDFFNEDSAAAICDKNPASVMSMLYSTKPDDWKAHMGAEGGAKEWVSCGKVAHPPPWMSYEEIATHVQLLKKGGYTGPLNWYKSFIRGIDKSLYERFTTDESKNLDIPAVVVTAAYDCGSRPEFQIPAAEKHLSNRRIERFECGHWIPLERPKELVILLEEFASGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJB2</accession>
    <name>B8MJB2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_041780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484654.1">
        <property type="nucleotide sequence ID" value="XM_002484609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJB2"/>
    <dbReference type="GeneID" id="8102955"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_041780"/>
    <dbReference type="eggNOG" id="ENOG502SBH1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8MJB2"/>
    <dbReference type="OrthoDB" id="2841294at2759"/>
    <dbReference type="PhylomeDB" id="B8MJB2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045469">
        <property type="entry name" value="Nis1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19271">
        <property type="entry name" value="Nis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877540" evidence="1">
        <location>
            <begin position="28"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="150" mass="15621" checksum="03843E0A1F4269E1" modified="2009-03-03" version="1">MGTNDPISTKMYKSVLSLGLIASTALAQSVSIGLPAAGAQLSTGTPTTFQIQRPDTLTGSQEIAVVIGISKCNSGGRCASPDESMGTVLYNGPFNPQFHETALPPYQNFTLEIPESAATDNGLVTVAHFSLVGASAWPMVEYLNQSITVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJG9</accession>
    <name>B8MJG9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipase 1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_046230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485122.1">
        <property type="nucleotide sequence ID" value="XM_002485077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJG9"/>
    <dbReference type="ESTHER" id="talsn-b8mjg9">
        <property type="family name" value="Fungal-Bact_LIP"/>
    </dbReference>
    <dbReference type="GeneID" id="8099534"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_046230"/>
    <dbReference type="eggNOG" id="ENOG502QRF9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029538_5_0_1"/>
    <dbReference type="InParanoid" id="B8MJG9"/>
    <dbReference type="OMA" id="EGCTIQN"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="PhylomeDB" id="B8MJG9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF5">
        <property type="entry name" value="LIP-DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877637" evidence="3">
        <location>
            <begin position="23"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED15169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="481" mass="51398" checksum="C591AC13BA8E1438" modified="2009-03-03" version="1">MHYSYILSTALCLSSTIGLSHSSSALPPSQDPWYTAPDNLLSFPAGSIIRIRPDPLSIYDSIGANITSASYNILYRTTDGNDLPSFAVATLFIPTLFIPSLKIAGKSKGLLSYQIPYNSPTVDASPSWTLLTSLNSTFPDIVAALEQGWYVSATDFEGPNATFAAGVAEGHAVLDGLRAVTKSSSSPVSDAKGTDWKIGLWGYSGGSIASEFAAELRASYAPEIQIAGVAIGGLPTPVTAVLDSVNETPYAGLIVSGLWGYANAFPIVESYLLSRLTDEVKSSGNFTAGRNMNILEIFAVYADVDVFSYFVGGEDDIFSSPLLQYFWNTQGVMGVHGLPDMPMYIYKAVEDQLAPVEYTDSLVNRYCDESEAAVTRKEAGVRILYERNMIGGHVAEETNADASAVEFLKNALKGGLGASWPSGNGYGCVVRNVTVGNDTSPDCTSIPIDMSDRQAFMQDKLEPVTGSERPEDDISNADTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJM7</accession>
    <name>B8MJM7_TALSN</name>
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            <fullName evidence="4">Integral membrane protein</fullName>
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    </protein>
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        <name evidence="2" type="ORF">TSTA_051630</name>
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    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485679.1">
        <property type="nucleotide sequence ID" value="XM_002485634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJM7"/>
    <dbReference type="GeneID" id="8103384"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_051630"/>
    <dbReference type="eggNOG" id="ENOG502SJVS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2335062_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJM7"/>
    <dbReference type="OrthoDB" id="5420247at2759"/>
    <dbReference type="PhylomeDB" id="B8MJM7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42029">
        <property type="entry name" value="AN04G07800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42029:SF2">
        <property type="entry name" value="WAX SYNTHASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="11452" checksum="510FEEE9BFD8ECAF" modified="2009-03-03" version="1">MPHGTFIFVPEQAYWWYLASTAIGLIISWSLHNVIAWMKNKAFMARWLSLAYIGTVFLAQPYWGVEIFANFAYFNNIDAAFYESCDHWKHYFGGQDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJS1</accession>
    <name>B8MJS1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2 finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_042130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484691.1">
        <property type="nucleotide sequence ID" value="XM_002484646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJS1"/>
    <dbReference type="STRING" id="441959.B8MJS1"/>
    <dbReference type="GeneID" id="8102990"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_042130"/>
    <dbReference type="eggNOG" id="ENOG502QW3K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015282_2_0_1"/>
    <dbReference type="InParanoid" id="B8MJS1"/>
    <dbReference type="OMA" id="TLQTYWN"/>
    <dbReference type="OrthoDB" id="4485682at2759"/>
    <dbReference type="PhylomeDB" id="B8MJS1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="791" mass="91070" checksum="DFBB70A77AC15D6B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJY2</accession>
    <name>B8MJY2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_042740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484752.1">
        <property type="nucleotide sequence ID" value="XM_002484707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJY2"/>
    <dbReference type="STRING" id="441959.B8MJY2"/>
    <dbReference type="GeneID" id="8099889"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_042740"/>
    <dbReference type="eggNOG" id="ENOG502SQ00">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030349_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJY2"/>
    <dbReference type="OMA" id="YPSKCVY"/>
    <dbReference type="OrthoDB" id="5344325at2759"/>
    <dbReference type="PhylomeDB" id="B8MJY2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED14799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="584" mass="65657" checksum="F6F7E6E96B3AAC69" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8MM48</accession>
    <name>B8MM48_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_098170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485798.1">
        <property type="nucleotide sequence ID" value="XM_002485753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MM48"/>
    <dbReference type="STRING" id="441959.B8MM48"/>
    <dbReference type="GeneID" id="8108456"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_098170"/>
    <dbReference type="eggNOG" id="ENOG502S3BW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001613_8_4_1"/>
    <dbReference type="InParanoid" id="B8MM48"/>
    <dbReference type="OMA" id="CTICKEA"/>
    <dbReference type="OrthoDB" id="4368520at2759"/>
    <dbReference type="PhylomeDB" id="B8MM48"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="3">
        <location>
            <begin position="228"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="2">
        <location>
            <begin position="471"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED13560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="736" mass="84520" checksum="0DCE958BB4A70004" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNR4</accession>
    <name>B8MNR4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">cystathionine gamma-synthase</fullName>
            <ecNumber evidence="10">2.5.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">O-succinylhomoserine (thiol)-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_103740</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-succinyl-L-homoserine + L-cysteine = L,L-cystathionine + succinate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20397"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57661"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="EC" id="2.5.1.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-cystathionine from O-succinyl-L-homoserine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the trans-sulfuration enzymes family. MET7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.48" evidence="10"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486391.1">
        <property type="nucleotide sequence ID" value="XM_002486346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNR4"/>
    <dbReference type="FunCoup" id="B8MNR4">
        <property type="interactions" value="174"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MNR4"/>
    <dbReference type="GeneID" id="8103077"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_103740"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011302_3_0_1"/>
    <dbReference type="InParanoid" id="B8MNR4"/>
    <dbReference type="OrthoDB" id="10047078at2759"/>
    <dbReference type="PhylomeDB" id="B8MNR4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000111">
        <property type="entry name" value="Cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000063">
        <property type="entry name" value="Probable cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12824">
        <property type="entry name" value="MRP-L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="167"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED14153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="893" mass="100555" checksum="74788DA08E16B911" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNT9</accession>
    <name>B8MNT9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_103970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486416.1">
        <property type="nucleotide sequence ID" value="XM_002486371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNT9"/>
    <dbReference type="STRING" id="441959.B8MNT9"/>
    <dbReference type="GeneID" id="8103169"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_103970"/>
    <dbReference type="HOGENOM" id="CLU_077443_0_0_1"/>
    <dbReference type="InParanoid" id="B8MNT9"/>
    <dbReference type="OMA" id="DHEMAAS"/>
    <dbReference type="OrthoDB" id="4507940at2759"/>
    <dbReference type="PhylomeDB" id="B8MNT9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="122"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED14178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="234" mass="27316" checksum="59C8BD4C610F51F0" modified="2009-03-03" version="1">MLTALHAAKEKLSQYYAMTDEIDSDLYAIGTIISPQQKLQFFRRKEWHDLKTDWHGQYRKSLEDYLEVYKWRLSDIQLVSKVQSSATVILELEVFCEPEESSGLHHSSSSHCDELTQYLKSTLASLAWDVLSIPATGAGVERLFNSTRDVCHYRRGSLKPETIQDIMMFICTSKLEIEEDQRVLINAYLSYEEIQAVKEEKDTQADEFEPISDKDEAEDEDQDEDVVEDYYYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNV7</accession>
    <name>B8MNV7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription initiation factor IIF subunit alpha, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_104160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF alpha subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486434.1">
        <property type="nucleotide sequence ID" value="XM_002486389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNV7"/>
    <dbReference type="STRING" id="441959.B8MNV7"/>
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            <end position="91"/>
        </location>
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            <end position="165"/>
        </location>
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            <end position="576"/>
        </location>
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            <end position="638"/>
        </location>
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            <begin position="42"/>
            <end position="73"/>
        </location>
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        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
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        </location>
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        </location>
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        <source>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED14196.1"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
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    <sequence length="698" mass="77890" checksum="B43ED91931A207C0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MP72</accession>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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            <end position="102"/>
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            <end position="193"/>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED14311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="315" mass="35007" checksum="8CC4C2C1A6AD04A1" modified="2009-03-03" version="1">MSKAVYWRQTLRFLTMIRSGLISMIYTQTLDMSATALKDSETITLISTDVERIVTNMRNLHELWASILEVGVAIWLLEREVWIACIIPLVISLGSVLAMVPVSTRFGQAQKRWIECVQDQLAMTSSMVSRMKTVQILGLSDILFKTVSRLREVEVQTSARFRKLLIWQIALSNIPVTLAPFATLTIYAVIALVRQDGSILSTTAFTTLALISILTDPLLVFCQAIPANIQAIACFSRIEKYYKNSTPLPVSSTTLSDDNIEENKESQPYKVSQAVNSPLVSFKNAEISRSSEKEPALKNLNLSICRGVVMIIGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPS8</accession>
    <name>B8MPS8_TALSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_052570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="AlphaFoldDB" id="B8MPS8"/>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_052570"/>
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    <dbReference type="InParanoid" id="B8MPS8"/>
    <dbReference type="OMA" id="AYRLDWE"/>
    <dbReference type="OrthoDB" id="5315324at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877888" evidence="1">
        <location>
            <begin position="22"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="202" mass="22262" checksum="D4449B9098A2CD5E" modified="2009-03-03" version="1">MKFSTPLILLSVQGHLLGALATKHSASSYPGLTDTDCQIRCPQSTNPSKVILPAIVNIQNATGDWDNALECWEVDTISSSLPGIDNAYRLDWEDGFDAGYQYIFYGESFMQAHSTPEPSLIVVGGGIGDLRMPSGRCLRVQGGDNFFSFGTKGKMTAWWAPGTVVSDFYFKDGVIPEHVVVPELEESQYGRLLKHQQERLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQ56</accession>
    <name>B8MQ56_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CCCH finger DNA binding protein, putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">TSTA_055820</name>
    </gene>
    <organism evidence="7 8">
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        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002487148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQ56"/>
    <dbReference type="FunCoup" id="B8MQ56">
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        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="169"/>
            <end position="207"/>
        </location>
    </feature>
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        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
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        <location>
            <begin position="169"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
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        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
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        <location>
            <begin position="272"/>
            <end position="314"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="22"/>
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            <begin position="47"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
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        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED13082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="355" mass="40195" checksum="FDB7F0681F31ADB1" modified="2009-03-03" version="1">MPPKKGADQAKKKKTTVEDKTFGMKNKKGGSARRQIAQLEAQAKHNKNADEKRKEAEKARRAAEKAAEEQAKREAAELFKPVQVQKVPFGVDPKTVVCQFYKQGHCEKGKKCKFSHDLSVERKSAKRDLYSDTRDSDAANGGKEKDTMDQWDEAKLRDVVLSKHGNPRTTTDKVCKYFIEAVENQKYGWFWTCPNGGDKCMYRHALPPGFVLKTKEQRAAEKALMEKSPMHTLTLEDFLESERHKLTGTLTPVTPETFAEWKKKRLDKKAAEEEARKAKEATGRTLFESGNWRTAGDSEEESDEEDDEDGAWNLEALRKETERLRMEKEEERLAKLHGLSTGETIGEAVAVDGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQH2</accession>
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        <submittedName>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
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        </cofactor>
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        <text evidence="2">Belongs to the cytochrome P450 family.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="EP450IV"/>
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    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
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    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED13374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="556" mass="62588" checksum="1CE687C7FEA768EF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQH7</accession>
    <name>B8MQH7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">TSTA_058680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487490.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQH7"/>
    <dbReference type="GeneID" id="8106470"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_058680"/>
    <dbReference type="eggNOG" id="ENOG502TB5Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2514172_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQH7"/>
    <dbReference type="OrthoDB" id="4525861at2759"/>
    <dbReference type="PhylomeDB" id="B8MQH7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="85" mass="9548" checksum="DFCC0659AC5F14E0" modified="2009-03-03" version="1">MPSNDHKNYDPTQSMANPGMNYWVRSTPPTQSTRRNAAGRGLFSGLQDMKHYNVDGGWANRHVVDEDVHGNNGSLFGWFSGFFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQL8</accession>
    <name>B8MQL8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_059270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002487507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQL8"/>
    <dbReference type="GeneID" id="8107397"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_059270"/>
    <dbReference type="HOGENOM" id="CLU_430938_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQL8"/>
    <dbReference type="OrthoDB" id="4221801at2759"/>
    <dbReference type="PhylomeDB" id="B8MQL8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
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        <source>
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        <source>
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</entry>
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    <accession>B8MR20</accession>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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                <person name="Fedorova-Abrams N.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
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</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <subcellularLocation>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED12474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="472" mass="51364" checksum="4579758DA701EB5D" modified="2009-03-03" version="1">MGNSPSKSPPGNSHAPLAGSHNVPGQERRVNRRTSINALSGTKASAADPSATRESATGQPASHGVAAGQQQRPQSRNVPPQTTQPIHEVPDRTGGRRFDGRHSAREAVEASSPVQVPAATNRPGRDEGYVPHESSANPANTYYSASHLQRGPPRLPLPIGDANATPGSPVIAPVDSQVDSVPFELENQIPQATISLDDPHVDEDEVEDEMQAYAMHGPGSKAVPTVIEWRGTGDRVFVTGTFVNWEKKFRLHKSDTEPNVKSTTLHLRPGTHHLKFIVDGDMRASDDLPTAVDFTNHLVNYIEVVADDIGGQRSRRESERAMKAMVPAGVHPPQVLPETVTAQQNQEALEKDEEPEEEPEEEIPMGNFRGTVPQFLIDIDREEEDAEYQRAANVIADAPTPPILPLFLGRSILNGTTPMKDDNSVLNYPNHTVLNHLATSSIKNGVLATSVTTRYKRKYVTTILYKPTGDVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTE9</accession>
    <name>B8MTE9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Chitin synthase</fullName>
            <ecNumber evidence="2 11">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_002590</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cell membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chitin synthase family. Class III subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 11"/>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487847.1">
        <property type="nucleotide sequence ID" value="XM_002487802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTE9"/>
    <dbReference type="STRING" id="441959.B8MTE9"/>
    <dbReference type="GeneID" id="8102870"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_002590"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004760_0_1_1"/>
    <dbReference type="InParanoid" id="B8MTE9"/>
    <dbReference type="OMA" id="WHLTYIK"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="PhylomeDB" id="B8MTE9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF11">
        <property type="entry name" value="CHITIN SYNTHASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 11 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="573"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="617"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="650"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="696"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="735"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="835"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="874"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="13">
        <location>
            <begin position="135"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED12193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="905" mass="100750" checksum="15838F24C02FD399" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTG6</accession>
    <name>B8MTG6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GABA permease GabA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_003560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487952.1">
        <property type="nucleotide sequence ID" value="XM_002487907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTG6"/>
    <dbReference type="FunCoup" id="B8MTG6">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MTG6"/>
    <dbReference type="GeneID" id="8098052"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_003560"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_2_3_1"/>
    <dbReference type="InParanoid" id="B8MTG6"/>
    <dbReference type="OMA" id="YCIGIGM"/>
    <dbReference type="OrthoDB" id="4476201at2759"/>
    <dbReference type="PhylomeDB" id="B8MTG6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000046">
        <property type="entry name" value="Amino-acid permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004756">
        <property type="entry name" value="AA_permease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00907">
        <property type="entry name" value="2A0304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF14">
        <property type="entry name" value="GABA PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED12298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="524" mass="56781" checksum="676FE73BDE202CF5" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTG8</accession>
    <name>B8MTG8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_003580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL54 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487954.1">
        <property type="nucleotide sequence ID" value="XM_002487909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTG8"/>
    <dbReference type="STRING" id="441959.B8MTG8"/>
    <dbReference type="GeneID" id="8098054"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_003580"/>
    <dbReference type="eggNOG" id="ENOG502SBZ8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086132_0_0_1"/>
    <dbReference type="InParanoid" id="B8MTG8"/>
    <dbReference type="OMA" id="YPEWLWR"/>
    <dbReference type="OrthoDB" id="10252718at2759"/>
    <dbReference type="PhylomeDB" id="B8MTG8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013870">
        <property type="entry name" value="Ribosomal_mL54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L54, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08561">
        <property type="entry name" value="Ribosomal_L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="38"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED12300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="252" mass="27094" checksum="BFA86336006B2F2A" modified="2009-03-03" version="1">MICQRCRTSLLSRVPVQQHSVRTPSSCVSIAFNTQSRFASTDTPKIPAMPPPPAPRQPGAGSVSIPSAISSATPGVSQPLSTPTDGIPKPPKWVNPGKGATSDDAAAATGPTHEPSSCVAGTPLKGLNYMKGKPDIVALEDHEYPDWLWTLLDDKAKKSNETGGVDVASLNKKQRKRYEKKMAALAATQPRKIPLHEQATDIIPADYNAERDGPRDIIAEAAVSIEKTEQITKSAREARRKGIRESNFLRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTS0</accession>
    <name>B8MTS0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N6-DNA-methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_005840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488209.1">
        <property type="nucleotide sequence ID" value="XM_002488164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTS0"/>
    <dbReference type="FunCoup" id="B8MTS0">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MTS0"/>
    <dbReference type="GeneID" id="8105558"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_005840"/>
    <dbReference type="eggNOG" id="KOG2904">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018398_0_0_1"/>
    <dbReference type="InParanoid" id="B8MTS0"/>
    <dbReference type="OMA" id="MPRIPYS"/>
    <dbReference type="OrthoDB" id="269872at2759"/>
    <dbReference type="PhylomeDB" id="B8MTS0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050320">
        <property type="entry name" value="N5-glutamine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895">
        <property type="entry name" value="HEMK METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895:SF74">
        <property type="entry name" value="MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED12555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="361" mass="40655" checksum="254D133E7A365D03" modified="2009-03-03" version="1">MPRIPTRLVLKAYKENPLLLDLLKECRTLENARNELRWLREGAIAKFPPPGTSSKGQDVYSTHTWQRELRKMCDDRSKGKPLQYILGDQPFGDLDILCRKGVLIPRGETESFTFHTRDVILEAHSAKYLGKSLRILDLCSGSGCISLLLHSLLASHFKDLTIVGVDVDPRAISLSQKNKLHNIRRGLLSPRAQNEVCFLKADILDSIESGKRSFLDTLQPHFPGSNTQSTWDVLISNPPYISTSNFCNGTTSRSVRKYEPVRALVPPIVHSPFWKELGFEHVAREDIFYVRLLSLIHQLHVKITVLECGDLEQARRIMTMAEVLSEKVGANGRQCVYIWNDGCAVNDNDGGARAVIIESLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTW6</accession>
    <name>B8MTW6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 11">D-xylulose reductase</fullName>
            <ecNumber evidence="9 11">1.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Xylitol dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_006100</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 11">Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>xylitol + NAD(+) = D-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 or 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 11">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.9" evidence="9 11"/>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488234.1">
        <property type="nucleotide sequence ID" value="XM_002488189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTW6"/>
    <dbReference type="FunCoup" id="B8MTW6">
        <property type="interactions" value="556"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MTW6"/>
    <dbReference type="GeneID" id="8105295"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_006100"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_5_1"/>
    <dbReference type="InParanoid" id="B8MTW6"/>
    <dbReference type="OMA" id="FETWYAM"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="PhylomeDB" id="B8MTW6"/>
    <dbReference type="UniPathway" id="UPA00146">
        <property type="reaction ID" value="UER00577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046526">
        <property type="term" value="F:D-xylulose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to D-xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0859">Xylose metabolism</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="15"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED12580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="354" mass="38010" checksum="D3AC59254E222BBD" modified="2009-03-03" version="1">MSLTETKNLSFVLEGIKKVKFEERPIPEIIDPYDVLINVKYTGICGSDVHYWEHGSIGSFVVREPMVLGHESSGVVSKVGSKVTTLKVGDQVAMEPGIPCRRCEPCKSGKYHLCINMAFAATPPYDGTLARYYRLPEDFCYKLPENIPLKEGALIEPLGVAVHVVKQGGVVPGNSVVVFGAGPVGLLCGAVAKAFGASKVIISDIQQSRLDFAKKYIADGTFQPARVSAEENANRLKEEHDILAGADVVLEASGAEPAVHTGIHALRTGGTFVQAGMGRSEINFPIMAVCGKELNFKGSFRYGSGDYKLAVELVATGKVSVKELITGEFKFEDAEQAYIDVKAGKGIKTIIVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUU4</accession>
    <name>B8MUU4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_110440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488620.1">
        <property type="nucleotide sequence ID" value="XM_002488575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUU4"/>
    <dbReference type="STRING" id="441959.B8MUU4"/>
    <dbReference type="GeneID" id="8107276"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_110440"/>
    <dbReference type="HOGENOM" id="CLU_1240851_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUU4"/>
    <dbReference type="OrthoDB" id="4330117at2759"/>
    <dbReference type="PhylomeDB" id="B8MUU4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF2">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED11864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="223" mass="24842" checksum="92FF605F888E7FCF" modified="2009-03-03" version="1">MSTPQRYRAACEACRYSKVRCSGGMVCDRCSERNFQCSYGIAHRAGKPKGSKKKVTLRLEAARRRIGKPSGESTLNTSGPSSQAYTVFTGHDCNHAFPSSNSSAYPLPIPIEKETDMGSYNTPLDYKNDVSPVIERNLHSSGDYQSTASNIPPYSSTLDRRSYIDGLKAYPQQNYGLYQDPSFIPWYFMTSFRPPEATPGAQEGGTYLFPIYPPHMLDDIFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8MV75</accession>
    <name>B8MV75_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_008270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962662">
        <property type="protein sequence ID" value="EED11531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488712.1">
        <property type="nucleotide sequence ID" value="XM_002488667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MV75"/>
    <dbReference type="STRING" id="441959.B8MV75"/>
    <dbReference type="GeneID" id="8110160"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_008270"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150206_0_0_1"/>
    <dbReference type="InParanoid" id="B8MV75"/>
    <dbReference type="OrthoDB" id="3261222at2759"/>
    <dbReference type="PhylomeDB" id="B8MV75"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="144" mass="15882" checksum="AFA6BFBF98A7785A" modified="2009-03-03" version="1">MIKGETVEPKESAKILGVVMDLQLNFKEHIANAATKGLVAAMALRRLKMISPRTARQLFKATVAPGADYASSVWIMQKHGAIAVIGAFRTVATIVAEAEARIHPFHNQHTKKVTKLWIDIQTLPKSNPLVKLKTDATWKFTSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8MVI2</accession>
    <name>B8MVI2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF659 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_007930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962663">
        <property type="protein sequence ID" value="EED11503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488819.1">
        <property type="nucleotide sequence ID" value="XM_002488774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MVI2"/>
    <dbReference type="STRING" id="441959.B8MVI2"/>
    <dbReference type="GeneID" id="8108947"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_007930"/>
    <dbReference type="HOGENOM" id="CLU_2224962_0_0_1"/>
    <dbReference type="InParanoid" id="B8MVI2"/>
    <dbReference type="OrthoDB" id="2976890at2759"/>
    <dbReference type="PhylomeDB" id="B8MVI2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11805" checksum="8DCC90746BC442A3" modified="2009-03-03" version="1">MAEVLQTTLEELNIEHKVLTIIADNAANNETLMPELYFNLKEKFDNMVSPANGERKLQRFQGLDSYMCCIAHALNLITPDHGPLDSENTPAKVAMEAHLSNSSFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8LT96</accession>
    <name>B8LT96_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Autophagy-related protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_070180</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Plays a role in the regulation of filamentous growth and chronological longevity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the ATG7 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340992.1">
        <property type="nucleotide sequence ID" value="XM_002340951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LT96"/>
    <dbReference type="FunCoup" id="B8LT96">
        <property type="interactions" value="772"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LT96"/>
    <dbReference type="GeneID" id="8102329"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_070180"/>
    <dbReference type="eggNOG" id="KOG2337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8LT96"/>
    <dbReference type="OrthoDB" id="338614at2759"/>
    <dbReference type="PhylomeDB" id="B8LT96"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01486">
        <property type="entry name" value="Apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.70:FF:000001">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme atg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000243">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006285">
        <property type="entry name" value="Atg7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01381">
        <property type="entry name" value="E1_like_apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="9">
        <location>
            <begin position="360"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606285-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED23605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="708" mass="78027" checksum="425B46868251E016" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTS6</accession>
    <name>B8LTS6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-3-methyladenine glycosylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_070750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkylbase DNA glycosidase AlkA family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341055.1">
        <property type="nucleotide sequence ID" value="XM_002341014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTS6"/>
    <dbReference type="FunCoup" id="B8LTS6">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LTS6"/>
    <dbReference type="GeneID" id="8106222"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_070750"/>
    <dbReference type="eggNOG" id="KOG1918">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_72_0_1"/>
    <dbReference type="InParanoid" id="B8LTS6"/>
    <dbReference type="OMA" id="VEMFAMF"/>
    <dbReference type="OrthoDB" id="415889at2759"/>
    <dbReference type="PhylomeDB" id="B8LTS6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032131">
        <property type="term" value="F:alkylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000004">
        <property type="entry name" value="DNA-3-methyladenine glycosylase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051912">
        <property type="entry name" value="Alkylbase_DNA_Glycosylase/TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003:SF5">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="5">
        <location>
            <begin position="197"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="24"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED23668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="382" mass="42012" checksum="ECBA533F67250298" modified="2009-03-03" version="1">MAPRRSARISSLADQKPLEAATAISKVNKSSKSKNKASKENGITKEQKESPTRKAQKKTKKEAAASAAEKALTTPQTPPRKQKGVTSVADNHNLRLTPPPSRLDRPVEPHRTNATLVTPRGSSVVAYPSLEDTSPSKTGLPRPIATTGNLLEKALEHLTSVDARLKPLIEQHHCRIFSPEGLAEQIDPFDSLISSIMAQQVSGAAAKSIKNKFLDLFDSSKDVQTDAEGKRRFPTPAQVAKLDIPTLRTAGLSQRKAEYVQGLAEKFASGELSTQKLLRASDEEVMEMLIAVRGLGRWSVEMFSCFALKRTDVFSTGDLGVQRGCAAFVGKDVNKLKAKGGKFKYMSESDMLELAEKFRPYRSLFMWYMWRVEEVDVAVLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8LU02</accession>
    <name>B8LU02_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ima1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_072250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341219.1">
        <property type="nucleotide sequence ID" value="XM_002341178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LU02"/>
    <dbReference type="STRING" id="441959.B8LU02"/>
    <dbReference type="GeneID" id="8102303"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_072250"/>
    <dbReference type="eggNOG" id="KOG4623">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013127_1_0_1"/>
    <dbReference type="InParanoid" id="B8LU02"/>
    <dbReference type="OMA" id="HVSYERH"/>
    <dbReference type="OrthoDB" id="5966927at2759"/>
    <dbReference type="PhylomeDB" id="B8LU02"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034992">
        <property type="term" value="C:microtubule organizing center attachment site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071765">
        <property type="term" value="P:nuclear inner membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042321">
        <property type="entry name" value="Ima1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018617">
        <property type="entry name" value="Ima1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28538">
        <property type="entry name" value="INTEGRAL INNER NUCLEAR MEMBRANE PROTEIN IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28538:SF1">
        <property type="entry name" value="INTEGRAL INNER NUCLEAR MEMBRANE PROTEIN IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09779">
        <property type="entry name" value="Ima1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="606"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Ima1 N-terminal" evidence="8">
        <location>
            <begin position="9"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="665"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="749"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="695"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="767"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED23832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="840" mass="95030" checksum="A1FD6AA2600AC2FB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8LU08</accession>
    <name>B8LU08_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.131</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSTA_072310</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the fourth and fifth mannose residues to the dolichol-linked oligosaccharide chain, to produce Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:29523"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="EC" id="2.4.1.131"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12 14">
            <dbReference type="Rhea" id="RHEA:29524"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.131" evidence="4 14"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341225.1">
        <property type="nucleotide sequence ID" value="XM_002341184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LU08"/>
    <dbReference type="FunCoup" id="B8LU08">
        <property type="interactions" value="419"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LU08"/>
    <dbReference type="GeneID" id="8105380"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_072310"/>
    <dbReference type="eggNOG" id="KOG1387">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017896_1_1_1"/>
    <dbReference type="InParanoid" id="B8LU08"/>
    <dbReference type="OMA" id="ARLYGWV"/>
    <dbReference type="OrthoDB" id="2276068at2759"/>
    <dbReference type="PhylomeDB" id="B8LU08"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03806">
        <property type="entry name" value="GT4_ALG11-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000168">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Alg11), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031814">
        <property type="entry name" value="ALG11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919:SF1">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15924">
        <property type="entry name" value="ALG11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="ALG11 mannosyltransferase N-terminal" evidence="16">
        <location>
            <begin position="107"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="15">
        <location>
            <begin position="348"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF15924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EED23838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="554" mass="61639" checksum="11B4FE911F4A60F0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUZ7</accession>
    <name>B8LUZ7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-carbamoylsarcosine amidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_061090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340005.1">
        <property type="nucleotide sequence ID" value="XM_002339964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUZ7"/>
    <dbReference type="STRING" id="441959.B8LUZ7"/>
    <dbReference type="GeneID" id="8102696"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_061090"/>
    <dbReference type="eggNOG" id="ENOG502QS7S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_7_1_1"/>
    <dbReference type="InParanoid" id="B8LUZ7"/>
    <dbReference type="OMA" id="VCNAYWS"/>
    <dbReference type="OrthoDB" id="1739143at2759"/>
    <dbReference type="PhylomeDB" id="B8LUZ7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF1">
        <property type="entry name" value="ISOCHORISMATASE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="31"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED22618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="242" mass="25956" checksum="A56DAB5C6FED29A7" modified="2009-03-03" version="1">MSTLSPSDYPAYAANISNKTQDPLDWGLRPALLILDVSKAYFSEASPLSLLSSTCGTAATLPANVSRLINAARSGECPVIWARTLFTNTKLHDAGIWTRKMPRQLLQGFSSKNEDGLHEFLEGMTPSAGSDGDSQKRLADLVIEKKFVSAFFGTNLAGQLAMIGVDTIVFCGARTGGEIRQSILDAQGLGFRGIVAADACADTCKETHFANLFDIQAKMGDVLTTDMAIEGLSKGWLWQASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVI1</accession>
    <name>B8LVI1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_073860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341387.1">
        <property type="nucleotide sequence ID" value="XM_002341346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVI1"/>
    <dbReference type="STRING" id="441959.B8LVI1"/>
    <dbReference type="GeneID" id="8107307"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_073860"/>
    <dbReference type="HOGENOM" id="CLU_013929_8_3_1"/>
    <dbReference type="InParanoid" id="B8LVI1"/>
    <dbReference type="OrthoDB" id="5425161at2759"/>
    <dbReference type="PhylomeDB" id="B8LVI1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="111"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED24000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="191" mass="21804" checksum="C4C87C1F4ED7EBE2" modified="2009-03-03" version="1">MADYLLSQRASQQVGEKWVYNLIQRRPEIESKFSRKYNYERAKCEDPKIIQEYFDRTGFAMGFCVTAKVITGSDRYARPKLLQPGNRGWVTAIEAVGSIEWALPSLVEDLNVSDNGWTTDKIGLEWLKTHFIPLTDGRTLGKYRMLILDGHGSHLTPEFDRICTENNIIPVCMPPHSSHRLQPLDVGCFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVT4</accession>
    <name>B8LVT4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_075860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341601.1">
        <property type="nucleotide sequence ID" value="XM_002341560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVT4"/>
    <dbReference type="STRING" id="441959.B8LVT4"/>
    <dbReference type="GeneID" id="8106185"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_075860"/>
    <dbReference type="eggNOG" id="ENOG502SSWS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008534_0_0_1"/>
    <dbReference type="InParanoid" id="B8LVT4"/>
    <dbReference type="OMA" id="TPQDWVE"/>
    <dbReference type="OrthoDB" id="10251744at2759"/>
    <dbReference type="PhylomeDB" id="B8LVT4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="478"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="516"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="662"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="718"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="203"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="544"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="662"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="774"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="801"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED24214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="890" mass="99011" checksum="370D86DE9DEC89E3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVX5</accession>
    <name>B8LVX5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Intermembrane space AAA protease IAP-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSTA_077080</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341728.1">
        <property type="nucleotide sequence ID" value="XM_002341687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVX5"/>
    <dbReference type="FunCoup" id="B8LVX5">
        <property type="interactions" value="1088"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LVX5"/>
    <dbReference type="GeneID" id="8101978"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_077080"/>
    <dbReference type="eggNOG" id="KOG0734">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_9_0_1"/>
    <dbReference type="InParanoid" id="B8LVX5"/>
    <dbReference type="OMA" id="MSHFEWA"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="PhylomeDB" id="B8LVX5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031942">
        <property type="term" value="C:i-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000002">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000175">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048438">
        <property type="entry name" value="Yme1-like_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF97">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21232">
        <property type="entry name" value="Yme1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 17" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="372"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EED24341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="807" mass="88588" checksum="EA5AE05A2E124017" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8LW50</accession>
    <name>B8LW50_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trafficking protein particle complex II-specific subunit 65 IgD3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_074560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341465.1">
        <property type="nucleotide sequence ID" value="XM_002341424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LW50"/>
    <dbReference type="STRING" id="441959.B8LW50"/>
    <dbReference type="GeneID" id="8104202"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_074560"/>
    <dbReference type="eggNOG" id="ENOG502RYDF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015118_0_0_1"/>
    <dbReference type="InParanoid" id="B8LW50"/>
    <dbReference type="OMA" id="IFSWTVY"/>
    <dbReference type="OrthoDB" id="5345392at2759"/>
    <dbReference type="PhylomeDB" id="B8LW50"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055420">
        <property type="entry name" value="IgD3_Trs65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024662">
        <property type="entry name" value="Trs65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159:SF1">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12735">
        <property type="entry name" value="IgD3_Trs65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex II-specific subunit 65 IgD3" evidence="2">
        <location>
            <begin position="405"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED24078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="577" mass="62715" checksum="4FC81E9F4B6AD3B0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWG0</accession>
    <name>B8LWG0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL2m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_076390</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341658.1">
        <property type="nucleotide sequence ID" value="XM_002341617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWG0"/>
    <dbReference type="FunCoup" id="B8LWG0">
        <property type="interactions" value="423"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LWG0"/>
    <dbReference type="GeneID" id="8101990"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_076390"/>
    <dbReference type="eggNOG" id="KOG0438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036235_3_0_1"/>
    <dbReference type="InParanoid" id="B8LWG0"/>
    <dbReference type="OMA" id="TAQRGNC"/>
    <dbReference type="OrthoDB" id="268576at2759"/>
    <dbReference type="PhylomeDB" id="B8LWG0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000128">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 11" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="10">
        <location>
            <begin position="107"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="9">
        <location>
            <begin position="210"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="255"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="355"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED24271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="409" mass="45470" checksum="AA305D1A682D3F49" modified="2009-03-03" version="1">MAVSFQPRLFLRALQLPIRGASFSSFRSYSSVIHETERPPVEESSSFDPSIAFAPPPTRDEAGVLVRTYKPRTPGVRHLRRPINDHLWKGRPVHRLTFPKRGHAKGGRNHSGRITVRHRGGGHKRRIRMVDFARNDPGPHVVERIEHDPGRTAHIALVRAQSNGKLSYILAADGMRAGDVIQSYMPGIPDDLWKSMGGVIDPGVLAARTAWRGNCLPLHMIPVGTLIFNVGLRPGKGGQLCRSAGTFATVIAKGTEQQKNEERKQQLEAEAGTGETEEKRLSQRDRQKVQRDASHVTIRLQSGEVRLIHKDCCATVGVASNPNYQYTQLGKAGRSRWLNIRPTVRGVAMNAMDHPHGGGRGKSKGNVHPKSPWGIPTKSGYKTRPKWKINKAVVVPRVRNQGKRRRGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXA0</accession>
    <name>B8LXA0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RelA/SpoT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_066310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340568.1">
        <property type="nucleotide sequence ID" value="XM_002340527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXA0"/>
    <dbReference type="STRING" id="441959.B8LXA0"/>
    <dbReference type="GeneID" id="8105099"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_066310"/>
    <dbReference type="eggNOG" id="ENOG502S64P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_406509_0_0_1"/>
    <dbReference type="InParanoid" id="B8LXA0"/>
    <dbReference type="OMA" id="VMHVWSE"/>
    <dbReference type="OrthoDB" id="4218265at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41773">
        <property type="entry name" value="GTP PYROPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41773:SF1">
        <property type="entry name" value="RELA_SPOT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RelA/SpoT" evidence="1">
        <location>
            <begin position="51"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="704" mass="80466" checksum="D7E8AD44371FF7D2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXE6</accession>
    <name>B8LXE6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_066730</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340614.1">
        <property type="nucleotide sequence ID" value="XM_002340573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXE6"/>
    <dbReference type="STRING" id="441959.B8LXE6"/>
    <dbReference type="GeneID" id="8106641"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_066730"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_436910_0_0_1"/>
    <dbReference type="InParanoid" id="B8LXE6"/>
    <dbReference type="OMA" id="VFEYWLT"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="PhylomeDB" id="B8LXE6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF41">
        <property type="entry name" value="CHITIN SYNTHASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="567"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED23227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="626" mass="71819" checksum="B246AE6173971159" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8LY59</accession>
    <name>B8LY59_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_067410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340691.1">
        <property type="nucleotide sequence ID" value="XM_002340650.1"/>
    </dbReference>
    <dbReference type="GeneID" id="8101259"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_067410"/>
    <dbReference type="HOGENOM" id="CLU_1176085_0_0_1"/>
    <dbReference type="InParanoid" id="B8LY59"/>
    <dbReference type="OMA" id="TIELTIX"/>
    <dbReference type="OrthoDB" id="3945463at2759"/>
    <dbReference type="PhylomeDB" id="B8LY59"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="226" mass="26033" checksum="6AB2288E693F11AE" modified="2009-03-03" version="1">MMLGSAGFVDSVTATTIELTIXXNKRKSPGSEKSDLSEATQLALKALQKYAVQNEILEHQQQGLVDALIGEKKRQKRGRPLGLINKDNPGEAQFFSPGRIEAARQQIQNIELQKEQGKIEAANRRTQKAFARQQKAQEIQERRETRIREREEKRRQKELEKEQLRVAREAQKEVKRAKERLAKQVNTKKRRYSKVIESNEEVSSKRPKTGISRSGRAINLPIRFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8LY63</accession>
    <name>B8LY63_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proteasome regulatory particle subunit (RpnG), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_067450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340695.1">
        <property type="nucleotide sequence ID" value="XM_002340654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LY63"/>
    <dbReference type="FunCoup" id="B8LY63">
        <property type="interactions" value="1116"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LY63"/>
    <dbReference type="GeneID" id="8105105"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_067450"/>
    <dbReference type="eggNOG" id="KOG0687">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031814_1_0_1"/>
    <dbReference type="InParanoid" id="B8LY63"/>
    <dbReference type="OMA" id="RLHCKVD"/>
    <dbReference type="OrthoDB" id="1452at2759"/>
    <dbReference type="PhylomeDB" id="B8LY63"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000013">
        <property type="entry name" value="Proteasome regulatory particle subunit (RpnG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000021">
        <property type="entry name" value="Putative proteasome regulatory particle subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049549">
        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21154">
        <property type="entry name" value="RPN7_PSMD6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="232"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED23308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="493" mass="54215" checksum="52E13A8E8B5F0335" modified="2009-03-03" version="1">MADPQFAKYPDLSLAQDIFNISNPSCASAVRQTSFKRLQDAITEHKMAPLYRHLAHPTEGILNTSGEGVPQQPSTNGAAAVSRPVITSNLLPGRKLSQKISFSWDEKLYDSLKEENKKELESFQKEEEEAAEAAGDTEVLAAQGKRAEFWARVGDKDKAIQTYEEVLEKTSILGTKIDLVLAMIRVGLFFGDRVFVKNTIERANALVESGGDWDRRNRLKAYKGLHLLTIRSYSLAAPLLLDSLSTFTSYELCSYSSLVIYAVLAGSLSLKRVDFKAKVVDAPEIKAILGEGEDMVSALTGAISSGPGAGDEEMKDVSSATPGTASTAINLTTLGTGSGAQAEAERPIDFSGLASLVSSLYSGNYRSFFIALASVEDTFLSQDRYLYEHRAWFVREMRLRGYQQLLQSYRVVGLTSMANDFGVTVDFLDRDLAKFIAAERISCTMDRVNGVIETNRPDDKNKQYADLVKQGDALITKLQKYGQAVRLRGSERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYA6</accession>
    <name>B8LYA6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosome biogenesis protein Nip7, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_063170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340222.1">
        <property type="nucleotide sequence ID" value="XM_002340181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYA6"/>
    <dbReference type="FunCoup" id="B8LYA6">
        <property type="interactions" value="1067"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LYA6"/>
    <dbReference type="GeneID" id="8110233"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_063170"/>
    <dbReference type="eggNOG" id="KOG3492">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097217_1_0_1"/>
    <dbReference type="InParanoid" id="B8LYA6"/>
    <dbReference type="OMA" id="MITRRCW"/>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="PhylomeDB" id="B8LYA6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.220:FF:000001">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="60S ribosome subunit biogenesis protein NIP7 pre-PUA" evidence="3">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="UPF0113" evidence="2">
        <location>
            <begin position="98"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED22835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="147" mass="16731" checksum="D05650B3A2980AB2" modified="2009-03-03" version="1">MRALTEEETKTLFQKLANYTGRSLNQLIQPTEDNERYVFRIQGSRVYYVKQSIANLATSVARDNLLSLGVCVGKFTKTMKFRLHITALDLIAPYARYKVTIKQNGEMPFLYGGNVVKAHVLRWSEDCPEHSGCVVFSQDDTPLVCHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYL7</accession>
    <name>B8LYL7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Sensor histidine kinase/response regulator, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSTA_068030</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340762.1">
        <property type="nucleotide sequence ID" value="XM_002340721.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LYL7"/>
    <dbReference type="GeneID" id="8109474"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_068030"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_50_4_1"/>
    <dbReference type="InParanoid" id="B8LYL7"/>
    <dbReference type="OMA" id="WVMKPIN"/>
    <dbReference type="OrthoDB" id="2015534at2759"/>
    <dbReference type="PhylomeDB" id="B8LYL7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009584">
        <property type="term" value="P:detection of visible light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000048">
        <property type="entry name" value="Sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.270:FF:000002">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013654">
        <property type="entry name" value="PAS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001294">
        <property type="entry name" value="Phytochrome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013515">
        <property type="entry name" value="Phytochrome_cen-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043150">
        <property type="entry name" value="Phytochrome_PHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065:SF10">
        <property type="entry name" value="PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065">
        <property type="entry name" value="SENSOR HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08446">
        <property type="entry name" value="PAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00360">
        <property type="entry name" value="PHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01033">
        <property type="entry name" value="PHYTOCHROME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="6 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Phytochrome chromophore attachment site" evidence="13">
        <location>
            <begin position="417"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="793"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="15">
        <location>
            <begin position="1238"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1043"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1085"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1138"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="11">
        <location>
            <position position="1289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EED23375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1403" mass="154597" checksum="A1BB941592D8844C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZE5</accession>
    <name>B8LZE5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_089350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478661.1">
        <property type="nucleotide sequence ID" value="XM_002478616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZE5"/>
    <dbReference type="STRING" id="441959.B8LZE5"/>
    <dbReference type="GeneID" id="8104902"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_089350"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="InParanoid" id="B8LZE5"/>
    <dbReference type="OMA" id="WEVANVI"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="PhylomeDB" id="B8LZE5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000417">
        <property type="entry name" value="Glucose 1-dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF83">
        <property type="entry name" value="(3R)-3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0684">Rhamnose metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED21698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="274" mass="28987" checksum="F5EF5E7C15205789" modified="2009-03-03" version="1">MAPPQLLVGKVCGITGGLTGIGREIALDYLRHGAKVAVNHLGGPNDESLVKSFHKDAEAVIRELNHSSIDGTRQFITVAGDISKPETGADFVAKIVEAFERLDVFISNAGVCQFAEFLEIEPSLLSQTVNINLCGAFYATQAAGRQMALHQSPSGGSIIGISSISALVGGGQQCHYCPTKAGVLSLMQSTAVALGKYNIRCNALLPGTIRTQLNDEDMSDEKKRTYMEGRIPLGRLGQPRDLAGPAVFLASDELSGYVTGAQILVDGGLFVNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8M153</accession>
    <name>B8M153_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RTA1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_082280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477958.1">
        <property type="nucleotide sequence ID" value="XM_002477913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M153"/>
    <dbReference type="STRING" id="441959.B8M153"/>
    <dbReference type="GeneID" id="8107686"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_082280"/>
    <dbReference type="eggNOG" id="ENOG502SKG2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033465_3_0_1"/>
    <dbReference type="InParanoid" id="B8M153"/>
    <dbReference type="OMA" id="YMVLARM"/>
    <dbReference type="OrthoDB" id="5384040at2759"/>
    <dbReference type="PhylomeDB" id="B8M153"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF15">
        <property type="entry name" value="LIPID TRANSPORTER ATNI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877484" evidence="6">
        <location>
            <begin position="22"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED20995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="437" mass="48852" checksum="F58433631AF11556" modified="2009-03-03" version="1">MKMHLITLMVPLLASIQTVHAIPLETPAPTSLSISTSLLKTSIPTISPNTLARRDTTSSASTTQMDSSPIQTLEATDSCTPTIAPDKNGYVPPTECNALYNYYPSFATAVAFSVLFGIILVTHIVQMFVYKTGFVWVIVMGIAWEFGGYLVRAFSTKHQQSEGMVTVSQILILLAPLWVNAFDYMILARMIWFFIPEKRIWFFKPSLLATIFVCLDFGSFVVQAIGGMMATPGAGASTIQTGLHIYMGGIGVQQFFICCFLVLAVQFHREMHHLERLGVLSGEKRRWKGLLYSLYFSLIAITVRIIYRLIEFTSGVGLNNPVTTHEWFMYAFDAFPMLLAGGVWCALYPGKILTGPDAKLPSSGLGRILCCGYCCCCCCRRGRKKKVAVSRGSERQELEELRLEEYHWVNRESYTSASSNWEPNKNMAYEPYRSQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1A4</accession>
    <name>B8M1A4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Small oligopeptide transporter, OPT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_082790</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478009.1">
        <property type="nucleotide sequence ID" value="XM_002477964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1A4"/>
    <dbReference type="GeneID" id="8105157"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_082790"/>
    <dbReference type="eggNOG" id="KOG2262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004965_1_1_1"/>
    <dbReference type="InParanoid" id="B8M1A4"/>
    <dbReference type="OMA" id="EVWHTGL"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="PhylomeDB" id="B8M1A4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="601"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="632"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="679"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED21046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="741" mass="82429" checksum="D791A42DAA6A7E32" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8M204</accession>
    <name>B8M204_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C6 transcription factor RosA-like, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_086130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478345.1">
        <property type="nucleotide sequence ID" value="XM_002478300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M204"/>
    <dbReference type="STRING" id="441959.B8M204"/>
    <dbReference type="GeneID" id="8104578"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_086130"/>
    <dbReference type="eggNOG" id="ENOG502R6NR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018979_3_0_1"/>
    <dbReference type="InParanoid" id="B8M204"/>
    <dbReference type="OMA" id="CPLVGSM"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="PhylomeDB" id="B8M204"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="527" mass="57945" checksum="2927099282225CA1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B8M259</accession>
    <name>B8M259_TALSN</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_087590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="EED21523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M259"/>
    <dbReference type="STRING" id="441959.B8M259"/>
    <dbReference type="GeneID" id="8100888"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_087590"/>
    <dbReference type="eggNOG" id="KOG0409">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035117_5_0_1"/>
    <dbReference type="InParanoid" id="B8M259"/>
    <dbReference type="OMA" id="VYSNRTM"/>
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    <dbReference type="PhylomeDB" id="B8M259"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF8">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE NADP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="5">
        <location>
            <begin position="4"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="6">
        <location>
            <begin position="179"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED21523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="318" mass="33578" checksum="6BAE7776F0F2C538" modified="2009-03-03" version="1">MATQIGWYGLGSMGLAMATNLQRHLSSTQALSLLYSNRTLSRGDSLQQLGAVPQSNFKDLVSRSNIIFTMVSNDAVLESLINTAIESPGTSIASKIFIDCSTVHPQTITSISSRLSSKSASFLCAPVFGGNPVATAGKLVFALAGSTPEVRHNIIKPLIQDVMGRKVIDCGEDPAKSSLLKIAGNIVTVSLMETVGEAQVFAEKTGLGTEAMEELINEAFGPIAGGYSKRLTTGAYAPELNTRPGFGVSLAIKDANHALSIAQDKGVELPSVELARDNMASARDYAGECLDSSSMYGILRQKAGLAFWNEKSRQGGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8M289</accession>
    <name>B8M289_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_087890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21553.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M289"/>
    <dbReference type="STRING" id="441959.B8M289"/>
    <dbReference type="GeneID" id="8100918"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_087890"/>
    <dbReference type="HOGENOM" id="CLU_903665_0_0_1"/>
    <dbReference type="InParanoid" id="B8M289"/>
    <dbReference type="OrthoDB" id="4840035at2759"/>
    <dbReference type="PhylomeDB" id="B8M289"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED21553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="308" mass="34003" checksum="AF43DDA954413794" modified="2009-03-03" version="1">MPDIGGLAKNGSENELQRAASHRAVDYHSSFLDLTDDTESRPVSPSNRLEPDTCDYPFLTYTGNAEPPCQSSLIHVTIEKCIARAAPVSEGSHNAQRPISFHVPRHALEHVGKWALCSRIPEHQEYQKYRILWIDGGGSHPNHIHESLPTASELSRAHMVCIFFKCTPDLGHKDVKTSQENMSGQEVITVALLYGIIVQLTSLLPENIKEDSELHCIQLAALDGSLGSAPVALSAIRVLLDHAVANPIAFIIDGLPFAEGPSTNSFLRELVEMLRHRDNDPCTLLLFSTEGESEVLSETIKLHERLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4D0</accession>
    <name>B8M4D0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_024490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479559.1">
        <property type="nucleotide sequence ID" value="XM_002479514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4D0"/>
    <dbReference type="STRING" id="441959.B8M4D0"/>
    <dbReference type="GeneID" id="8097980"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_024490"/>
    <dbReference type="eggNOG" id="ENOG502SM1Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022339_1_0_1"/>
    <dbReference type="InParanoid" id="B8M4D0"/>
    <dbReference type="OMA" id="IWVPVWG"/>
    <dbReference type="OrthoDB" id="5281682at2759"/>
    <dbReference type="PhylomeDB" id="B8M4D0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED19125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="588" mass="66841" checksum="F386C8A46503588A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4I0</accession>
    <name>B8M4I0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_024970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479609.1">
        <property type="nucleotide sequence ID" value="XM_002479564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4I0"/>
    <dbReference type="STRING" id="441959.B8M4I0"/>
    <dbReference type="GeneID" id="8106714"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_024970"/>
    <dbReference type="eggNOG" id="ENOG502SPD4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009400_0_0_1"/>
    <dbReference type="InParanoid" id="B8M4I0"/>
    <dbReference type="OMA" id="PRPDWAM"/>
    <dbReference type="OrthoDB" id="5386574at2759"/>
    <dbReference type="PhylomeDB" id="B8M4I0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021582">
        <property type="entry name" value="Aim21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11489">
        <property type="entry name" value="Aim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="825"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="611"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="673"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="864"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="877"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="935" mass="100999" checksum="781A5B2C7DB5F8FD" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4N5</accession>
    <name>B8M4N5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_025470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479664.1">
        <property type="nucleotide sequence ID" value="XM_002479619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4N5"/>
    <dbReference type="STRING" id="441959.B8M4N5"/>
    <dbReference type="GeneID" id="8107959"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_025470"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1124517_0_0_1"/>
    <dbReference type="InParanoid" id="B8M4N5"/>
    <dbReference type="OMA" id="WIEEPLA"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="PhylomeDB" id="B8M4N5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF4">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED19230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="275" mass="32060" checksum="A9B2D514F42A7BED" modified="2009-03-03" version="1">MRKQLESNFNGMFKVFFKSTPEQRDLRNRFEARMKQLIKDEQLQQKLIPPFEAGCRRINPDEGYLITLQKSNMQPIFESIKNICAHWVITSDGQEHPADILIAVTGRAGSLEATSDYFIRLLRKFLREQVKKFDVRLDAQTDFDKHTQAYMQNMVWTGTYRRSTLHYIQTLAENRWEDYAWEYHGNRYDYWEQGLSWIEEPLADSLGRDEAEALHSSTIPTKDSDISFYLRESSPLPSSLGVKDECLLEELAIEQVVETKLSEIIQPSVPTSIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4S0</accession>
    <name>B8M4S0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphotransferase</fullName>
            <ecNumber evidence="8">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_026630</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="8"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479789.1">
        <property type="nucleotide sequence ID" value="XM_002479744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4S0"/>
    <dbReference type="FunCoup" id="B8M4S0">
        <property type="interactions" value="1068"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M4S0"/>
    <dbReference type="GeneID" id="8098945"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_026630"/>
    <dbReference type="eggNOG" id="KOG1369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014393_5_0_1"/>
    <dbReference type="InParanoid" id="B8M4S0"/>
    <dbReference type="OMA" id="YPNFEGY"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="PhylomeDB" id="B8M4S0"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000034">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF30">
        <property type="entry name" value="GLUCOKINASE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="9">
        <location>
            <begin position="12"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="10">
        <location>
            <begin position="232"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED19355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="493" mass="53785" checksum="7CD5125E11B36D86" modified="2009-03-03" version="1">MAPGPSLDAALRVAREFDLPSDQVQRGVDEFLSQMAEGMAKNGTNLSQIPTYVTSVPNGTEKGLYLAVDLGGTNFRVCSINLRGDSTFDLTQSKVAIPRDLMVAPSYKELFKFLAKQVESFLETHHNEHFEATVRRRRLTGTTDEYRREEIFDLGFTFSFPVHQTSINRGTLIRWTKGFDIPDAVGQDVCLMLQDAINELHLPVRVAALVNDTVGTLMARSYTSPGKTETVIGAIFGTGTNGAYVEKLNRLTKLNTKGEPAADATQQMVINTEWGSFDNNLSVLPNTLYDQQLDAASVNPGIQMFEKRVSGMFLGEILRLAILGLAKDATARLLRGDGTLIPTDSPLYTPWGIDTSFLSVIEADTTSDLAETKAALFEHFKVSNASTDDAQAIQAIGHAIAKRSARLSAIALAAILIDTKRIDTDETVDIGVDGSLVEFYPKFVDYIREAMREIKGIGEKEKKVRIGIAKDGSGVGAALIALVAHKGYAIESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8M510</accession>
    <name>B8M510_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_028970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480050.1">
        <property type="nucleotide sequence ID" value="XM_002480005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M510"/>
    <dbReference type="STRING" id="441959.B8M510"/>
    <dbReference type="GeneID" id="8099016"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_028970"/>
    <dbReference type="eggNOG" id="ENOG502SMH7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018003_2_3_1"/>
    <dbReference type="InParanoid" id="B8M510"/>
    <dbReference type="OMA" id="TELILIW"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="PhylomeDB" id="B8M510"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="10"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="365" mass="43261" checksum="164AA76B3CC9E1D7" modified="2009-03-03" version="1">MDKDNSVVIIAVMGATGSGKSTFIQLVTGSKDVGVGDTLLSETKEVCEYHFSHKGINYILIDTPGFDGSYRSDIEVTELILIWLEKSMVSGRRLNGIIYLYRISDIRMGGSALRNTQMFRKLVGKDALQNVKLATVFWEQVPDKDVALAFRREKELRDLWGSMLEHGAQIVRLQNNRKSGLRFLEKFSEKAKVVLEDQNEIVNLGKLTEDTAALRELVKEVDDLERELKENLRLEKKRLEKDIERQKSRQQHEVRKLQAEMERNLEAQRQIERHRLTQEEEDAQGDYERKRMKLEADKERQERQRRREIKELEKRERGELKRRKRRAKRLNRYYQRQYVCIGYTPKRTCVKCRGKLTRRKYYYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8M518</accession>
    <name>B8M518_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_029050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480058.1">
        <property type="nucleotide sequence ID" value="XM_002480013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M518"/>
    <dbReference type="GeneID" id="8099024"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_029050"/>
    <dbReference type="HOGENOM" id="CLU_1497204_0_0_1"/>
    <dbReference type="InParanoid" id="B8M518"/>
    <dbReference type="OMA" id="MHFASAT"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877290" description="GPI anchored protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED19624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="17362" checksum="C2DF1FCE542F0D2C" modified="2009-03-03" version="1">MLHSIFLAVLIALGPSAVLASPGVNDLPPPITGIVSSAMSLASSYESEYTTIPPDAQSAVSSALSLASSYDSYGNIEASSARSLASSYASEYGDGGSDSTPTTTSSSGSQATLTGTSTGSGSRGSTTITRTTDLAGATATSASATGGATLNKAPVVPVGGGMMATMGVLAASIGALAVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5A1</accession>
    <name>B8M5A1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HRQ family protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_029790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED19707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="48998" checksum="E25365E0AC6DBE7E" modified="2009-03-03" version="1">MEQSESHVEIAKRLIETFRSLAVNFPEHAQSNIDLLKKTLASPQKSQILISVLIGFALLFQVFLKFRQVRTHKRSRFLESPGFPLPEILDDFNWATQEPLQLRPFKPKYHLTMALESLNPSELILMDKTYKERMQYRRKILKEHRETVIAMFDESDPRIIAAVKELYRYIMSTYLPVRYPTMFRLHETAFETGKAYMLENLVLNELYPSEVTELTSPMRALEILYKTIDEDYLILLPEKSNDDDDISAANVKYRLVAYETCYPAGFNPREKLGKLLADIHGPVPGYQEKLEKSMDRHFANIEVGKYVKRANWSMSTNTELFAAFGGLHSSANETKVEDKIKEGTLDVDSTFLRCERQTLHRLPTSRAIVFGFHTYTYPIKQIKEEGSGQDLATAIDGLKEGSVPKIYGYKRGAVWGDAVKAYLRS</sequence>
</entry>
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            <taxon>Eurotiomycetes</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
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    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="79"/>
            <end position="286"/>
        </location>
    </feature>
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        <location>
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            <end position="39"/>
        </location>
    </feature>
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        <location>
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            <end position="520"/>
        </location>
    </feature>
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        <location>
            <begin position="542"/>
            <end position="774"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
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        <location>
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            <end position="327"/>
        </location>
    </feature>
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            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
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        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
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            <end position="517"/>
        </location>
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            <end position="586"/>
        </location>
    </feature>
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            <begin position="594"/>
            <end position="605"/>
        </location>
    </feature>
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            <end position="664"/>
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    </feature>
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            <begin position="685"/>
            <end position="711"/>
        </location>
    </feature>
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        <location>
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            <end position="728"/>
        </location>
    </feature>
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        <location>
            <begin position="739"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="EED19769.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="774" mass="83909" checksum="07E1D2C8FC23E3AF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6D3</accession>
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        <submittedName>
            <fullName evidence="3">Cell cycle control protein Cdc123</fullName>
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        <name evidence="3" type="ORF">TSTA_026190</name>
    </gene>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC123 family.</text>
    </comment>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:magnesium ion binding"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="P:eukaryotic translation initiation factor 2 complex assembly"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6G3</accession>
    <name>B8M6G3_TALSN</name>
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        <submittedName>
            <fullName evidence="2">Thioesterase family protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">TSTA_026480</name>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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                <person name="Andrianopoulos A."/>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="RefSeq" id="XP_002479772.1">
        <property type="nucleotide sequence ID" value="XM_002479727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6G3"/>
    <dbReference type="STRING" id="441959.B8M6G3"/>
    <dbReference type="GeneID" id="8098929"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_026480"/>
    <dbReference type="eggNOG" id="ENOG502SSJB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052827_0_2_1"/>
    <dbReference type="InParanoid" id="B8M6G3"/>
    <dbReference type="OMA" id="RVFYNDK"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="PhylomeDB" id="B8M6G3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF1">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="175"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="274" mass="31410" checksum="BD6EF551A9461B7E" modified="2009-03-03" version="1">MFHVLKKSYNTLLFRSVPIPLRRDILPAQLTSTPVRNLTTYVLNNTENTKRSRWRRRIILGLLSGSLGYFFGKSYIYEQCFPTEPDSVQDVKYVKLIGKLLDNLPATWEARSDPRFVEWEAYDGFSNGDKERRLTSGPLRGSRGLAVQKIFWNEEQKRCVNVVHFGKSLEGWPRIVHGGILATVLDETLGRVAIRSVPAHTGVTAHLDIKYINAVKSDRPYLVVAYLDKERSTDRKAYVTGGIFDPITKKVYCRCEALFVVPKGLSLRRIEERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8M750</accession>
    <name>B8M750_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_035000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480703.1">
        <property type="nucleotide sequence ID" value="XM_002480658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M750"/>
    <dbReference type="STRING" id="441959.B8M750"/>
    <dbReference type="GeneID" id="8104343"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_035000"/>
    <dbReference type="eggNOG" id="ENOG502SB51">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072829_2_1_1"/>
    <dbReference type="InParanoid" id="B8M750"/>
    <dbReference type="OMA" id="FIDETCE"/>
    <dbReference type="OrthoDB" id="548474at2759"/>
    <dbReference type="PhylomeDB" id="B8M750"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038966">
        <property type="entry name" value="TMA17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422:SF1">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="170" mass="18932" checksum="E700AEAACA0A8538" modified="2009-03-03" version="1">MSAEAQPISPIAFAEAIKELPLSSLYAKVSELRNSISHLTRSNEELRTYIIESEEGPDSPDNKELEAYVLENEEVMQAMAERIRLLKVEVEGRGQRWMEEVLEDGDGGEIEEDAQSPPLVNGVSSHEVDGVTDDNSERRVNGLTNPSNRQDGDGEEQRNGDDEDDEGIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7E1</accession>
    <name>B8M7E1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrion biogenesis protein (Mdm31), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_035880</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MDM31/MDM32 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480795.1">
        <property type="nucleotide sequence ID" value="XM_002480750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7E1"/>
    <dbReference type="FunCoup" id="B8M7E1">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M7E1"/>
    <dbReference type="GeneID" id="8107537"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_035880"/>
    <dbReference type="eggNOG" id="ENOG502QQJG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016236_2_1_1"/>
    <dbReference type="InParanoid" id="B8M7E1"/>
    <dbReference type="OMA" id="DFLCAEN"/>
    <dbReference type="OrthoDB" id="17678at2759"/>
    <dbReference type="PhylomeDB" id="B8M7E1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012571">
        <property type="entry name" value="Mdm31/Mdm32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068:SF0">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08118">
        <property type="entry name" value="MDM31_MDM32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="729"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="173"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED20361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="750" mass="83899" checksum="97AA239819F4C310" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7G6</accession>
    <name>B8M7G6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved serine proline-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_036120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480820.1">
        <property type="nucleotide sequence ID" value="XM_002480775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7G6"/>
    <dbReference type="STRING" id="441959.B8M7G6"/>
    <dbReference type="GeneID" id="8101883"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_036120"/>
    <dbReference type="eggNOG" id="ENOG502RDJ2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008050_0_0_1"/>
    <dbReference type="InParanoid" id="B8M7G6"/>
    <dbReference type="OMA" id="RIEMTYY"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="PhylomeDB" id="B8M7G6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08681">
        <property type="entry name" value="C2_fungal_Inn1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037791">
        <property type="entry name" value="C2_fungal_Inn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052981">
        <property type="entry name" value="Ingression_C2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052">
        <property type="entry name" value="CONSERVED SERINE PROLINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_2G01790)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052:SF3">
        <property type="entry name" value="INGRESSION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="10"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="896"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="846"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED20386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="925" mass="101827" checksum="DF8DC6947578EB26" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7M0</accession>
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        <recommendedName>
            <fullName evidence="3">Extracellular thaumatin domain protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">TSTA_028560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480007.1">
        <property type="nucleotide sequence ID" value="XM_002479962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7M0"/>
    <dbReference type="STRING" id="441959.B8M7M0"/>
    <dbReference type="GeneID" id="8108371"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_028560"/>
    <dbReference type="eggNOG" id="ENOG502SSWE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083650_2_1_1"/>
    <dbReference type="InParanoid" id="B8M7M0"/>
    <dbReference type="OMA" id="ANVQNAC"/>
    <dbReference type="OrthoDB" id="5144514at2759"/>
    <dbReference type="PhylomeDB" id="B8M7M0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195:SF6">
        <property type="entry name" value="SECRETED THAUMATIN-LIKE PROTEIN CALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED19573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="23309" checksum="061741AD6F4D2EB8" modified="2009-03-03" version="1">MPGIKDIQVFHITNITFFSTFFHQTNQANMYFTKALSLLATIGTLASAAPTGSMNVTHLDNLPTTHGSANTNGANGGSVDIHNNMKDTIYYWSVSQDAGSMKSLEPGASYTESWRTNPDGGGISIKMAMKPEQVDVLQYEYTLQGDTIFWDLSLIDMGTGSKFTEVGFAVTSNDSGCPSATCAPGDTACADAYLVWNDDHATHGCPAGTQMTLNIGPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7P3</accession>
    <name>B8M7P3_TALSN</name>
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        <submittedName>
            <fullName evidence="7">RNA exonuclease, putative</fullName>
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        <name evidence="7" type="ORF">TSTA_028780</name>
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    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
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            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="441959.B8M7P3"/>
    <dbReference type="GeneID" id="8098997"/>
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    <dbReference type="eggNOG" id="KOG2248">
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    <dbReference type="HOGENOM" id="CLU_036102_0_0_1"/>
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    <dbReference type="OMA" id="VEPHEPI"/>
    <dbReference type="OrthoDB" id="16516at2759"/>
    <dbReference type="PhylomeDB" id="B8M7P3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06137">
        <property type="entry name" value="DEDDh_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF114">
        <property type="entry name" value="EXONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="415"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="415"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED19596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="449" mass="50078" checksum="B256724FE97CEDB0" modified="2009-03-03" version="1">MADNQTSNFAILTRKKEKIEQNGEKYTCRVCNRAFGSQKALRSHRSATNHEVRCSVCNKGFAIDKDLRQHARIHLSAAPGNIASASKVESVVTMTEVTRRVLEPENCTTSLALQVPLIRRGLEELSLNEDHYQQEVSEKQVMAQKQGFLHRLNTYTLLPSAEYETIYRALLAACHATNVLNAEQYILQGVTGRKTNTNVRYEEFRPTPQAVAGQRKRKIVAIDCEMVGLWKGSDSVVLLCSVDVLTGETLLNTLVNPVSKVKSWRSTVSGVTRKAMNVAIERGQALRGWPAARKALWQYVDTETILVGHALQNDLNVLGIFHPRIVDTAILAAQAVFLDHQGKKFPQTYGLKKLLACFVNMAIQTGKRGHDCLEDTLATREVAIWCMRNPESLKTWGSRTFAEYEARRLEIQRAREKAKEEEKEAKIASRKAGKTGSGASINATNGVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7S7</accession>
    <name>B8M7S7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar epimerase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_030710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480240.1">
        <property type="nucleotide sequence ID" value="XM_002480195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7S7"/>
    <dbReference type="STRING" id="441959.B8M7S7"/>
    <dbReference type="GeneID" id="8101750"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_030710"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_12_2_1"/>
    <dbReference type="InParanoid" id="B8M7S7"/>
    <dbReference type="OMA" id="WGERAYY"/>
    <dbReference type="OrthoDB" id="2130169at2759"/>
    <dbReference type="PhylomeDB" id="B8M7S7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="342" mass="37452" checksum="433C723B7B132A32" modified="2009-03-03" version="1">MSKIFLTGATGYIGGEALYAISKKHPDFSISALVRDTTKNQRIKAAFSNVRIVNGELDDFELLKREAANADIVVHTADASDHVIAAQAIAAGLAEGHTASKPGYWLHVGGTGILTFRDSDRNVYGEYDDKIYNDWEGVDELTHLPDHAFHRNVDKIVLEAGTKNADRVKTALICPPTIYGPGRGPINQKSRQVYALASMTLQIKKAPLLGAGKSIWNNVHIQDLGQLFVLLTEAAVAGRQDKGLWGAEGYYFVENGEHVWGDVSRSIAQIAAKEGYIPEPSVGEVDIETCEKFAGYQAMSWGMNSRGKAKRAVKLLDWKPVAPSLEEELPGIVNMEYNDLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7S8</accession>
    <name>B8M7S8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conidiation protein Con-6, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_030720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480241.1">
        <property type="nucleotide sequence ID" value="XM_002480196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7S8"/>
    <dbReference type="GeneID" id="8101751"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_030720"/>
    <dbReference type="eggNOG" id="ENOG502S75W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107705_1_0_1"/>
    <dbReference type="InParanoid" id="B8M7S8"/>
    <dbReference type="OMA" id="NEMRGYK"/>
    <dbReference type="OrthoDB" id="5419162at2759"/>
    <dbReference type="PhylomeDB" id="B8M7S8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018824">
        <property type="entry name" value="Conidiation-specific_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052670">
        <property type="entry name" value="UPF0654_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576:SF2">
        <property type="entry name" value="PROTEIN CON-6, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03615)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576">
        <property type="entry name" value="UPF0654 PROTEIN C11D3.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10346">
        <property type="entry name" value="Con-6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="102" mass="11195" checksum="FD818118AD544F08" modified="2009-03-03" version="1">MSAFQNLDPAGVSPEDRINALRGYKATINNPRVSEEAKQHAHEMIDSLGGDQPRAEMKQFDQQHDQNRVAGGLKASLSNPRVSQQGKNQAQEKLDKLSGPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7T9</accession>
    <name>B8M7T9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_030810</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480252.1">
        <property type="nucleotide sequence ID" value="XM_002480207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7T9"/>
    <dbReference type="FunCoup" id="B8M7T9">
        <property type="interactions" value="323"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M7T9"/>
    <dbReference type="GeneID" id="8101760"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_030810"/>
    <dbReference type="eggNOG" id="KOG0239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_12_1_1"/>
    <dbReference type="InParanoid" id="B8M7T9"/>
    <dbReference type="OMA" id="AYANMER"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="PhylomeDB" id="B8M7T9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01366">
        <property type="entry name" value="KISc_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000065">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF45">
        <property type="entry name" value="PROTEIN CLARET SEGREGATIONAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="555"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="215"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="311"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="507"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="648"/>
            <end position="655"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED19818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="903" mass="100636" checksum="7D45F7D1FDFA6AFF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8L9</accession>
    <name>B8M8L9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_037520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480966.1">
        <property type="nucleotide sequence ID" value="XM_002480921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8L9"/>
    <dbReference type="STRING" id="441959.B8M8L9"/>
    <dbReference type="GeneID" id="8100597"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_037520"/>
    <dbReference type="eggNOG" id="ENOG502SQ1I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139329_0_0_1"/>
    <dbReference type="InParanoid" id="B8M8L9"/>
    <dbReference type="OMA" id="DLDCVKG"/>
    <dbReference type="OrthoDB" id="42919at2759"/>
    <dbReference type="PhylomeDB" id="B8M8L9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044662">
        <property type="entry name" value="HS1/DABB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178:SF17">
        <property type="entry name" value="STRESS-RESPONSE A_B BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="2">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED20532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="113" mass="13353" checksum="F0EA986E98939858" modified="2009-03-03" version="1">MFKFRSEVTAAHKATFVRELKRLKNLECVKSHRLVVGGPSVTDPIERSKGFEFALLSFHENRQELDKYQASKEHHWVTSTYLLPYKEDVIRFDFEVAPEEEHMWNFLPIIGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8W4</accession>
    <name>B8M8W4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_038340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481061.1">
        <property type="nucleotide sequence ID" value="XM_002481016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8W4"/>
    <dbReference type="STRING" id="441959.B8M8W4"/>
    <dbReference type="GeneID" id="8107876"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_038340"/>
    <dbReference type="HOGENOM" id="CLU_671169_0_0_1"/>
    <dbReference type="InParanoid" id="B8M8W4"/>
    <dbReference type="OrthoDB" id="4369561at2759"/>
    <dbReference type="PhylomeDB" id="B8M8W4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="410" mass="45081" checksum="30610709C7E3BD85" modified="2009-03-03" version="1">MAVTLNNIKFYHPPSLPARPIKSTSPNDHHTSKRTDSTPSTHSKLSFSPFSQPALPHPLPPRPPAIIPCSHHTASATLHFPSSTSHTADSHPVCKNDFHRALDDFFSAKNGKNDEDGESSIRVPTQDHGNDNRAHATSPNLEVLSQMTASLPSPSFSHPRIHRQHSAHLNRLHQRPISSTLIRQISAQGSSIVNRERSETTHASGVLSHSPKSGGSTLRNESTDLQGASGDSKRASSCQLEESSNRKRSPSARLSPLSTPQVVVPVLSRRSVSLRRKSNYLDNPEREDAGESLRPSKRRRRILDEASSTSRVPRQLSSESPRAKRPESPPEDLSAESEPIPVQGFLRLRSSGSEVIYCLELSQTHFSSSVAGGQIESPRPHQRTARPATRIRFTPEEDAFIVQLKAQELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9F9</accession>
    <name>B8M9F9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monoxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_115180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481711.1">
        <property type="nucleotide sequence ID" value="XM_002481666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9F9"/>
    <dbReference type="STRING" id="441959.B8M9F9"/>
    <dbReference type="GeneID" id="8101328"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_115180"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1189970_0_0_1"/>
    <dbReference type="InParanoid" id="B8M9F9"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="PhylomeDB" id="B8M9F9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF1">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06050)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="16"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED17719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="242" mass="26249" checksum="D6637BBBFF53CBEC" modified="2009-03-03" version="1">MATVGFLDAILTVLEKGILIQFGRKFTNVIEDSPTDGVEFGFADGSTESASILVGADGIHSTVREYLYPDLQTIFLGMAGITAAVSRAQLKLPEDYHIPVTIMSPQGAFVIAPQQADGSEVLIGKQQRVSAGKPGWDREFVADKQGAVEFLQTGNAHFPEFVRNAVSQIDPVKVNKWPFFVVPKLDKWASETRRVLIVGDAAHAIPPSAGQGINQAFEDVYVLALLLSKADKIENFQDALSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9W4</accession>
    <name>B8M9W4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major facilitator superfamily transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_118820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482108.1">
        <property type="nucleotide sequence ID" value="XM_002482063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9W4"/>
    <dbReference type="STRING" id="441959.B8M9W4"/>
    <dbReference type="GeneID" id="8108556"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_118820"/>
    <dbReference type="eggNOG" id="ENOG502SMKU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009650_2_1_1"/>
    <dbReference type="InParanoid" id="B8M9W4"/>
    <dbReference type="OMA" id="SAMGWGR"/>
    <dbReference type="OrthoDB" id="3353407at2759"/>
    <dbReference type="PhylomeDB" id="B8M9W4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021822">
        <property type="entry name" value="DUF3405"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205:SF2">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11885">
        <property type="entry name" value="DUF3405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED18116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="704" mass="81055" checksum="3BD5D900103A82DE" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAH4</accession>
    <name>B8MAH4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Voltage-gated K channel beta subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_112310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481390.1">
        <property type="nucleotide sequence ID" value="XM_002481345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAH4"/>
    <dbReference type="STRING" id="441959.B8MAH4"/>
    <dbReference type="GeneID" id="8105697"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_112310"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_1"/>
    <dbReference type="InParanoid" id="B8MAH4"/>
    <dbReference type="OMA" id="EQPAYNM"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="PhylomeDB" id="B8MAH4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF6">
        <property type="entry name" value="VIC POTASSIUM ION CHANNEL, BETA SUBUNIT (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="25"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED17398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="349" mass="38958" checksum="E6B0F5BDB2647BCB" modified="2009-03-03" version="1">MPVPKDLPRMQYRFLGRSGLQVSAISLGGWLTYGGHVENENTFSCMKAAYDVGINFFDCAESYSNGESERVMGQAIKKFGWKRNDIVVSTKIYWGEAFGENPVNNRGLSRKHVVEGLNGSLERLGLEYVDIVFAHRPDRDTPIEETVRAFNHVINTGKAFYWGTSEWDADEIATAWRYADKLGLIGPVAEQPQYNMFSRNKVEKDFAHLYEEVGLGLTIWSPLKVGILTGKYNNGIPENSRLANSTDPSVERMRARIGGKEWDTFISVVAKLKPIADRLEVSQPNLAMAWVLANKNVSSAITGASRPDQIYESVKSLVVIEKLTPEILAEIDGILGNKPPVVKRRSPMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAR0</accession>
    <name>B8MAR0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-1,2-mannosyltransferase (Ktr4), putative</fullName>
            <ecNumber evidence="4">2.4.1.131</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_115480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.131" evidence="4"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481742.1">
        <property type="nucleotide sequence ID" value="XM_002481697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAR0"/>
    <dbReference type="FunCoup" id="B8MAR0">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MAR0"/>
    <dbReference type="GeneID" id="8101358"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_115480"/>
    <dbReference type="eggNOG" id="KOG4472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024327_4_3_1"/>
    <dbReference type="InParanoid" id="B8MAR0"/>
    <dbReference type="OMA" id="WCFFLYQ"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="PhylomeDB" id="B8MAR0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF7">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED17750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="397" mass="46744" checksum="96FAF8AD6814C64A" modified="2009-03-03" version="1">MAIARPIRLLGAVGILGVLLVLYKFSHSTTGGFTPVGTDKISDMKRDPLLDPTGEPEGILWRAEEHDYSPESENSARINATLLSLVRNQELTELVTTMKDLERTWNHKFNYPWTFLNDEPFTPEFKKRTQEVTKAKCYYEQVPKDHWEAPEWIDDELVKESNKILEENNIQYSDKPSYHKMCRWNSGMFYKHPALANTRYYWRVEPNVQFFCNVDYDVFRYMQDYNKTYGFTINLFDAPESLPTLWPETERFLAEHPEYISENNMMEWLVDDKLRPEHNKKANGYSTCHFWSNFEIGDMNFFRSEAYEAYFNHLDRAGGFFYERWGDAPVHSIALGLFEDASKVHWFRDIGYRHIPYFNCPNSPKCSGCTPGKFYEGASFLAKEDCRPNYFKYVGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>B8MB34</accession>
    <name>B8MB34_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Multidrug resistance protein, putative</fullName>
            <ecNumber evidence="15">1.3.1.74</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_124580</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.74" evidence="15"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482727.1">
        <property type="nucleotide sequence ID" value="XM_002482682.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MB34"/>
    <dbReference type="GeneID" id="8098409"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_124580"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_5_1"/>
    <dbReference type="InParanoid" id="B8MB34"/>
    <dbReference type="OMA" id="NMLIQFW"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="PhylomeDB" id="B8MB34"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032440">
        <property type="term" value="F:2-alkenal reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF399">
        <property type="entry name" value="ABC TRANSPORTER ATNG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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</entry>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_120240"/>
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    <dbReference type="OrthoDB" id="508139at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED18274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="107" mass="12497" checksum="A0767C6330188426" modified="2009-03-03" version="1">MATESDIGKGHTAVCNALLIRRNEIADRFWNDMEEPDHALVELAFEVFDRYGCIQPKFKNHPIKWGFHAIPDLTEKKSRHFFVVTSPKIRFSEIGHENRQRDDADDE</sequence>
</entry>
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        <name evidence="4" type="ORF">TSTA_120390</name>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
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    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:signal transduction involved in filamentous growth"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SIGNALING MUCIN HKR1-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="SIGNALING MUCIN HKR1-RELATED"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877440" evidence="3">
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            <begin position="21"/>
            <end position="715"/>
        </location>
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        <location>
            <begin position="632"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
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        <location>
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            <end position="366"/>
        </location>
    </feature>
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        <location>
            <begin position="389"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="625"/>
        </location>
    </feature>
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        <location>
            <begin position="389"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="608"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED18291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="715" mass="70617" checksum="E8A86194B93E9C47" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDX1</accession>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="nucleotide sequence ID" value="XM_002483237.1"/>
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    <dbReference type="STRING" id="441959.B8MDX1"/>
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    <dbReference type="HOGENOM" id="CLU_004495_2_3_1"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF16">
        <property type="entry name" value="7-KETO 8-AMINOPELARGONIC ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
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            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED16048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="524" mass="56994" checksum="C89D9BB19FC35D05" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B8MES3</accession>
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        <recommendedName>
            <fullName evidence="7">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_020150</name>
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        <lineage>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002484145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MES3"/>
    <dbReference type="STRING" id="441959.B8MES3"/>
    <dbReference type="GeneID" id="8108826"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_020150"/>
    <dbReference type="eggNOG" id="KOG0859">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064620_1_1_1"/>
    <dbReference type="InParanoid" id="B8MES3"/>
    <dbReference type="OMA" id="NTKLMIM"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="PhylomeDB" id="B8MES3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000017">
        <property type="entry name" value="Synaptobrevin-like protein Sybl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF168">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="12">
        <location>
            <begin position="11"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="13">
        <location>
            <begin position="160"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED16956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="255" mass="27994" checksum="7ACDA545CBD79A45" modified="2009-03-03" version="1">MASSSRPSSSLLYSCIAHGTTILAEHSSPGASSTSASSLASIILPKISHDKPQKLTYTHDRLFVHYIADSPSSQDGGSGSKNGSTEPDSHSSLSYLVVATAEQGRRIPFAFLLEAKRKFLSAYPPSTTDFSTLPAYGCAAYNSELRALLQQFNTAPPSDSLASARREIDSVRDIMTENIERVLERGERIDLLVDKTDRLGGSAHDFRMRSRGLRRRMWWKNVKVMFLLGVVLVFLIYLFVGMGCGLPSWGRCIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8MF02</accession>
    <name>B8MF02_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_008960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483005.1">
        <property type="nucleotide sequence ID" value="XM_002482960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MF02"/>
    <dbReference type="STRING" id="441959.B8MF02"/>
    <dbReference type="GeneID" id="8100757"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_008960"/>
    <dbReference type="eggNOG" id="ENOG502SJ0E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115019_0_0_1"/>
    <dbReference type="InParanoid" id="B8MF02"/>
    <dbReference type="OMA" id="YNMTHND"/>
    <dbReference type="OrthoDB" id="3454835at2759"/>
    <dbReference type="PhylomeDB" id="B8MF02"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="20"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED15771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="167" mass="19033" checksum="359FE52FA1C86238" modified="2009-03-03" version="1">MAASNPSRQLLCLTMLGYKKPGLTEEELCSFQVCQHSQLVCGLMEKYGVVRYSITHNAAKPMNLLPRVFDPKYVEFSDYDFIVQIIIPNLDVFFALKEDPVYQERVAMDHLNFADRSSPSRKTRMSLGYVHEIIRDGKVVYVDAVEPECQIYNNLLSDQGKFIAADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8MF23</accession>
    <name>B8MF23_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sugar transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_012310</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483356.1">
        <property type="nucleotide sequence ID" value="XM_002483311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MF23"/>
    <dbReference type="GeneID" id="8104079"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_012310"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="InParanoid" id="B8MF23"/>
    <dbReference type="OMA" id="EIAYPAH"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="PhylomeDB" id="B8MF23"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF3">
        <property type="entry name" value="HEXOSE TRANSPORTER PROTEIN (AFU_ORTHOLOGUE AFUA_8G04480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="39"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED16122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="520" mass="56852" checksum="FA6ED0439AA7978E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFC5</accession>
    <name>B8MFC5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_017340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483893.1">
        <property type="nucleotide sequence ID" value="XM_002483848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFC5"/>
    <dbReference type="GeneID" id="8108991"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_017340"/>
    <dbReference type="eggNOG" id="KOG3105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_4_0_1"/>
    <dbReference type="InParanoid" id="B8MFC5"/>
    <dbReference type="OMA" id="DRTCIEN"/>
    <dbReference type="OrthoDB" id="4694018at2759"/>
    <dbReference type="PhylomeDB" id="B8MFC5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="60"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="387"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED16659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="548" mass="63042" checksum="730599DB0D8BC764" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFE8</accession>
    <name>B8MFE8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acid phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_017570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483916.1">
        <property type="nucleotide sequence ID" value="XM_002483871.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483917.1">
        <property type="nucleotide sequence ID" value="XM_002483872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFE8"/>
    <dbReference type="STRING" id="441959.B8MFE8"/>
    <dbReference type="GeneID" id="8109014"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_017570"/>
    <dbReference type="eggNOG" id="KOG2157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049222_2_0_1"/>
    <dbReference type="InParanoid" id="B8MFE8"/>
    <dbReference type="OMA" id="PENDWVV"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027746">
        <property type="entry name" value="TTL"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED16682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="336" mass="36550" checksum="23862B3FDB807C2D" modified="2009-03-03" version="1">MHILVVNDDGPPSQKLSPYIRPFVDALEDAGHRVSVAIPAASRSWIGKAHIIGASLTATYVHPDSFQEDGTWVEEDATEDHSKPAAVTTNSHLPPTPAASTEHLNVTGSAPVSPEDYWVVVTNGTPASCTQLGIYELFPDRGPIDLVISGPNHGRNASTIYNLSSGTVGGALEAATCGKRGIALSFGSKDEQPREVIAAAARLSTRVIEHLYRNWSDKVELYNLNVPMREDVESRPVRYTSALRNEWTKGSLYAEVGNHGTSDEDGDKDTLQRKGKPNRVRQFQWSTELSDIKKSLAESLRGTDARTVLDGYTSVTPLKANFWHPSGFSGDLQLDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFN9</accession>
    <name>B8MFN9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_020870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484263.1">
        <property type="nucleotide sequence ID" value="XM_002484218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFN9"/>
    <dbReference type="STRING" id="441959.B8MFN9"/>
    <dbReference type="GeneID" id="8109991"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_020870"/>
    <dbReference type="HOGENOM" id="CLU_495377_0_0_1"/>
    <dbReference type="InParanoid" id="B8MFN9"/>
    <dbReference type="OMA" id="CVANNIP"/>
    <dbReference type="OrthoDB" id="2426273at2759"/>
    <dbReference type="PhylomeDB" id="B8MFN9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596:SF2">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G17550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="136"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="550" mass="61695" checksum="4F7F6F601A821045" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MG44</accession>
    <name>B8MG44_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbonyl reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_010290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483145.1">
        <property type="nucleotide sequence ID" value="XM_002483100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MG44"/>
    <dbReference type="STRING" id="441959.B8MG44"/>
    <dbReference type="GeneID" id="8105668"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_010290"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_4_1"/>
    <dbReference type="InParanoid" id="B8MG44"/>
    <dbReference type="OMA" id="QVNCYTH"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="PhylomeDB" id="B8MG44"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF252">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED15911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="327" mass="35941" checksum="3D24D1C148FD40B8" modified="2009-03-03" version="1">MLLQPHIPELPKYTSLEGRTVLVTGGTNGLGYESARQFLTFKAPRLIITARNAARGVESVQALRADPDVIKGNPNAIIDMFPLDLDDYKSVTKFCDKVKSEAPDLDVLVCNAGISQMDFKMSASGHEQIMQVNCYSNFLVALELLPVLRATAAKKGQPSHLTFVGSAMQTVHSFASNPIPPSENVLDFLDNAKNASKLKRYNDSKLAVNAFVRYIATKVSSSEVIINDFCPGAVPTNLEHNTPWLIKKIVTVLKRTVGRSIQEGGRTVVYASILAGTESHGKFLQHNKVVPGPPYLDEDAGKEFTQRLWTDLLAELKTVDPQITTWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MG63</accession>
    <name>B8MG63_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">O-methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_010480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483164.1">
        <property type="nucleotide sequence ID" value="XM_002483119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MG63"/>
    <dbReference type="GeneID" id="8105687"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_010480"/>
    <dbReference type="eggNOG" id="ENOG502RQGF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8MG63"/>
    <dbReference type="OMA" id="NHFMVGK"/>
    <dbReference type="OrthoDB" id="1535081at2759"/>
    <dbReference type="PhylomeDB" id="B8MG63"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF18">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="1">
        <location>
            <begin position="212"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="367" mass="40978" checksum="A81B09069DE4F41F" modified="2009-03-03" version="1">MTPPVAAVLAQTVTVTASLSFIPVAVYFNLFSTLVKIGKAATSKQITDARNEERSVDEKEQAPLCYQLTHDVLYSLSSIGLVDLVQDDVFEANDITRHMIAMPSAQHGTLHFATEPMFAGAFLMRKLIDTKFEYPFKALETPTQYGYKLLGQDDLAKEHTYSIMARQGRMDSFNQFMVGKFGKFGKMPERVKSFGYDLDSAVSGTESDVVWVDIGGGRGEMLLELKEAYPTLSKSALVLQEFNPDIGSVREVTQMEWNFASDTPQPVEGALNYSLTHIFHNLPDLDALELMQKVSKAMALYSRLIIQEFTKNKSYGKMHATMITLYGGRLRSSAEWKRLAALCGLRVTFEAYPEAGEGLIEMRKIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHN5</accession>
    <name>B8MHN5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_011250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483250.1">
        <property type="nucleotide sequence ID" value="XM_002483205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHN5"/>
    <dbReference type="GeneID" id="8109898"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_011250"/>
    <dbReference type="eggNOG" id="ENOG502SXHS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137473_1_1_1"/>
    <dbReference type="InParanoid" id="B8MHN5"/>
    <dbReference type="OMA" id="SPHINIY"/>
    <dbReference type="OrthoDB" id="2120024at2759"/>
    <dbReference type="PhylomeDB" id="B8MHN5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED16016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="113" mass="12881" checksum="C722331378D40E96" modified="2009-03-03" version="1">MFRLNPARRIHGAARHIILSDIASSQFTRRGFTSSIPRSQQPQPPQLEKSNTFKEGISAYRPFGAPFLKVFLGAIFTYQVIYYAWMKLETSEKKFLKNGLEKEAKKLAAEAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHX9</accession>
    <name>B8MHX9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calcium homeostasis protein Regucalcin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_015450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483693.1">
        <property type="nucleotide sequence ID" value="XM_002483648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHX9"/>
    <dbReference type="FunCoup" id="B8MHX9">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MHX9"/>
    <dbReference type="GeneID" id="8106287"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_015450"/>
    <dbReference type="eggNOG" id="KOG4499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036110_3_0_1"/>
    <dbReference type="InParanoid" id="B8MHX9"/>
    <dbReference type="OMA" id="KKPAMCA"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="PhylomeDB" id="B8MHX9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF47">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="4">
        <location>
            <begin position="29"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED16459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="317" mass="35737" checksum="27EBC83CB189807B" modified="2009-03-03" version="1">MAGKLGASADVQRWTVTESYLDIRGGLLEGPFYTPERNELRFVDLDYEKVYFVNLAKGPSATRVLHTESPIGVTADMIDDSGNNTQIVVAAKHGFATMDYQSGALTYIHRVHTSEEQAYRMRFNDGAVDNQGRFWAGSSIDHKYVQGQHEGTLYRLDPDLSLHEMVHQMTTPNGMGWNDADNIMYVTDSPHGKIYAYDFDARTGSITNRRDFLTFEASFGEPDGFAMDVEGCLWVAVWRGSRIIRVNPQGEITGEILFPTRFITCPEFVGSELIVTTAIEQEPYKYPQSARWGGKVYRVDVGIRGKPRNAFRRGYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>B8MI44</accession>
    <name>B8MI44_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_022600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484440.1">
        <property type="nucleotide sequence ID" value="XM_002484395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MI44"/>
    <dbReference type="GeneID" id="8107097"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_022600"/>
    <dbReference type="HOGENOM" id="CLU_2607635_0_0_1"/>
    <dbReference type="InParanoid" id="B8MI44"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED17206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="79" mass="8849" checksum="55FBF560483773F6" modified="2009-03-03" version="1">MERIETSNVIIARSTSPVKDEFFSCETAHGLLVRAVDVQKVETKEPLHVTIVARSTGNAFMTSRWVSVGVYSPKKRLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIG8</accession>
    <name>B8MIG8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-C homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_045220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-C/MIF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485013.1">
        <property type="nucleotide sequence ID" value="XM_002484968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIG8"/>
    <dbReference type="STRING" id="441959.B8MIG8"/>
    <dbReference type="GeneID" id="8099486"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_045220"/>
    <dbReference type="eggNOG" id="ENOG502S47H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8MIG8"/>
    <dbReference type="OMA" id="CHGRVQV"/>
    <dbReference type="OrthoDB" id="1939643at2759"/>
    <dbReference type="PhylomeDB" id="B8MIG8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019237">
        <property type="term" value="F:centromeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051455">
        <property type="term" value="P:spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06993">
        <property type="entry name" value="cupin_CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000033">
        <property type="entry name" value="Centromere protein C 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028386">
        <property type="entry name" value="CENP-C/Mif2/cnp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025974">
        <property type="entry name" value="Mif2/CENP-C_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028929">
        <property type="entry name" value="Mif2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684:SF11">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11699">
        <property type="entry name" value="CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15624">
        <property type="entry name" value="Mif2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mif2 N-terminal" evidence="9">
        <location>
            <begin position="14"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Mif2/CENP-C cupin" evidence="8">
        <location>
            <begin position="489"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="405"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="575"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="617"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00057947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF15624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED15060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="630" mass="69738" checksum="570FB2CFABBA76C6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJ38</accession>
    <name>B8MJ38_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_051360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485653.1">
        <property type="nucleotide sequence ID" value="XM_002485608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJ38"/>
    <dbReference type="GeneID" id="8106338"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_051360"/>
    <dbReference type="eggNOG" id="ENOG502SVBM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051551_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJ38"/>
    <dbReference type="OMA" id="NTMACKG"/>
    <dbReference type="OrthoDB" id="4526357at2759"/>
    <dbReference type="PhylomeDB" id="B8MJ38"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="338" mass="36191" checksum="0DF8202933442811" modified="2009-03-03" version="1">MLKIASTRAELPGVQPLTRLNAPGNTMACKGPGTDGPLQTALLESTSAATTRASEGQKIFSPIAAFLDKHRSQTTGLAPHLLRALTALSDDLASVAQQHFNAYISGISTTSILPALSPSPSFSPILNPLPPSPPPSRPPSGLNQSTYATITQYAPVKLTPTTHSKSPVKKPMPLVKQPLPDNRLFVRLLADHAARKMEAYAIYSSLRSQLNSNSAVLKEVQATKTGFTLCPSSPEALLALEAQKETISAFFVNCQIERSSRWVSYRVTNVPRKIGQILDGRYSLIPINPTLLSLEISETTGLKPISISETATSAANPNTLSSSWFVNFPEGTKSPLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJ80</accession>
    <name>B8MJ80_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_041470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484622.1">
        <property type="nucleotide sequence ID" value="XM_002484577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJ80"/>
    <dbReference type="GeneID" id="8109732"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_041470"/>
    <dbReference type="HOGENOM" id="CLU_1644858_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJ80"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED14669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="161" mass="18226" checksum="9CF59036EE514669" modified="2009-03-03" version="1">MGFSWLKAHTLFLSGITMLYCLWVHPYVCKNLFITNCLDQARAACGLLSTLGRTCCACQRENNENVSHAGFVAPSNEQNHRTFSDDQLEVDRSSLIESDMDNYAAVYNISNVSYKLKADKFMDEPDGFRDFFDLGLLDDVNLNLDDQSWNMGEVTQNKSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJD2</accession>
    <name>B8MJD2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_041960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484674.1">
        <property type="nucleotide sequence ID" value="XM_002484629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJD2"/>
    <dbReference type="STRING" id="441959.B8MJD2"/>
    <dbReference type="GeneID" id="8102973"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_041960"/>
    <dbReference type="eggNOG" id="ENOG502SNFG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068309_1_0_1"/>
    <dbReference type="InParanoid" id="B8MJD2"/>
    <dbReference type="OMA" id="FVECNFF"/>
    <dbReference type="OrthoDB" id="2564987at2759"/>
    <dbReference type="PhylomeDB" id="B8MJD2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877636" evidence="1">
        <location>
            <begin position="18"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="199" mass="21181" checksum="C78C25D67A3280D0" modified="2009-03-03" version="1">MKAQFITAAGLFAGALGQQSIFSGAGFGTYYYDVENVDDCGTSFKYQNMGPVMCNQETALTLNDINSNYIVAMNNTQLGSDPSLYCGKKVVVSVNGQASDLPLFIGDGCQRCGGGSLDATTWNAQAAPGLDFSLSVLNEISGGAGCTNGHVDITWEIVDETLYNFDTNAPASLSMPIWQHSSIALGPDFCLLFYFQNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJH1</accession>
    <name>B8MJH1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_046250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485124.1">
        <property type="nucleotide sequence ID" value="XM_002485079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJH1"/>
    <dbReference type="STRING" id="441959.B8MJH1"/>
    <dbReference type="GeneID" id="8099536"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_046250"/>
    <dbReference type="eggNOG" id="KOG0698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013173_1_4_1"/>
    <dbReference type="InParanoid" id="B8MJH1"/>
    <dbReference type="OMA" id="HVMKLSM"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="PhylomeDB" id="B8MJH1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF803">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="9">
        <location>
            <begin position="17"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED15171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="320" mass="35151" checksum="A431DC41D6FC5206" modified="2009-03-03" version="1">MLPTRTMHIEDAVLLFDAGAATVQGGRVSQEDRHVILLPHQFPPTKSTDKFALFATYDGHGSADVSEHVRQNLPNLLIKRPEFEKGDYETAIIKSFEDEDELLLQMVMEENTQAVIAGSTVALCLVNLTKGLMVVGNVGDSHIFLARRDEGSEFITWQERLTVAHKPHDPSEKSRIEQAGGAVHTYGGTARLGTLNMSRALGDLQYKNPINNLNLTRGTKKAKRANASGSTIRGNILSNEAYVRTIKLDPNSRYTLLVCTDGVTDVTDEKQLMTEVMSDFVAGRRARDIAKMVTTATGEQPHSDNSTCVIAFLDGVRALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJT1</accession>
    <name>B8MJT1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_042230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484701.1">
        <property type="nucleotide sequence ID" value="XM_002484656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJT1"/>
    <dbReference type="STRING" id="441959.B8MJT1"/>
    <dbReference type="GeneID" id="8103000"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_042230"/>
    <dbReference type="eggNOG" id="ENOG502RS4C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011455_3_0_1"/>
    <dbReference type="InParanoid" id="B8MJT1"/>
    <dbReference type="OMA" id="RMFETEL"/>
    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="PhylomeDB" id="B8MJT1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF21">
        <property type="entry name" value="REGULATORY PROTEIN LEU3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="98"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED14748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="542" mass="61591" checksum="C9B454A9D7E60170" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-02-23" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKR3</accession>
    <name>CYB2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName>L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="5">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_043820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2021" name="PLoS Comput. Biol." volume="17" first="e1009446" last="e1009446">
            <title>Experimental and computational investigation of enzyme functional annotations uncovers misannotation in the EC 1.1.3.15 enzyme class.</title>
            <authorList>
                <person name="Rembeza E."/>
                <person name="Engqvist M.K.M."/>
            </authorList>
            <dbReference type="PubMed" id="34555022"/>
            <dbReference type="DOI" id="10.1371/journal.pcbi.1009446"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
    </reference>
    <comment type="function">
        <text evidence="5 6">Catalyzes the oxidation of (S)-lactate (L-lactate) to pyruvate with subsequent transfer of electrons to cytochrome c. Also displays oxidase activity in vitro, catalyzing the oxidation of a broad range of 2-hydroxyacids, such as glycolate, (S)-lactate, 2-hydroxyoctanoate, (S)-2-hydroxyglutarate and to a lesser extent mandelate, to the corresponding 2-oxoacids, with a reduction of O2 to H2O2 (PubMed:34555022). However, the physiological activity of this enzyme is most likely to function as an L-lactate dehydrogenase. May be involved in the utilization of (S)-lactate as a sole source of carbon for growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2S)-2-hydroxycarboxylate + O2 = a 2-oxocarboxylate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:16789"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:58123"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glycolate + O2 = glyoxylate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:25311"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29805"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-lactate + O2 = pyruvate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:55868"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2-hydroxyoctanoate + O2 = 2-oxooctanoate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:67940"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:133514"/>
            <dbReference type="ChEBI" id="CHEBI:176689"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-2-hydroxyglutarate + O2 = 2-oxoglutarate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:27662"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16782"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>mandelate + O2 = phenylglyoxylate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:68968"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:25147"/>
            <dbReference type="ChEBI" id="CHEBI:36656"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="1">Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of two discrete domains, an N-terminal cytochrome b domain and a C-terminal flavin-binding domain. The cytochrome b domain is required for efficient cytochrome c reduction.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="5"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484865.1">
        <property type="nucleotide sequence ID" value="XM_002484820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKR3"/>
    <dbReference type="SMR" id="B8MKR3"/>
    <dbReference type="STRING" id="441959.B8MKR3"/>
    <dbReference type="GeneID" id="8097890"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_043820"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020639_1_1_1"/>
    <dbReference type="InParanoid" id="B8MKR3"/>
    <dbReference type="OMA" id="WSYVAGG"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="PhylomeDB" id="B8MKR3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003973">
        <property type="term" value="F:(S)-2-hydroxy-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000012">
        <property type="entry name" value="Mitochondrial cytochrome b2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF82">
        <property type="entry name" value="CYTOCHROME B2, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07200)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0349">Heme</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000454855" description="L-lactate dehydrogenase (cytochrome)">
        <location>
            <begin position="1"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="2">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="3">
        <location>
            <begin position="101"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="179"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="404"/>
            <end position="408"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="427"/>
            <end position="428"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="34555022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="EMBL" id="EED14912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED14912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="496" mass="53913" checksum="9E20BE8E81F07C69" modified="2009-03-03" version="1">MARVLDAAEVAKHNTPESCWVILYGKVYDVTEFISSHPGGVKVILRLAGTDATEEYDPIHPPGTLEENLKPEALLGTVDPETLPKPDKQQSSPEEEEQGPPPMETLFNLDEIEQVATKQVSRKAWGYYYSAADDLISKNFNREIYRSILLRPRVFIDVGKCDLSTTILGHRVGLPIYISPAAMARLAHPAGEAGIAAACRGFGAMQMISNNASMSPEQIVENAAPDQVFGWQLYVQMERKKSEAMLARVEKLKAIKCVILTLDAPVPGKREDDMRTDNIGKKLPVSSAKVAEKEVETLPDGTPVPTDGGGGVGKQLFAGTAYDLTWKETLTWLTKVTKLPIILKGLQTHEDAYIASLYAPQVKGIILSNHGGRALDTAPPAVHTLLEIRKYCPEVFDKIEVLVDGGIRRGTDVVKALCLGARAVGIGRPALWGLGAGGIAGVERTLEILADETKTCMQLLGVEKISDLGPEYINSRIVEQQIYDGPSGLEKARAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8ML73</accession>
    <name>B8ML73_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase, 2OG-Fe(II) oxygenase family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_044540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484941.1">
        <property type="nucleotide sequence ID" value="XM_002484896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ML73"/>
    <dbReference type="STRING" id="441959.B8ML73"/>
    <dbReference type="GeneID" id="8104130"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_044540"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="IGNMAHT"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="PhylomeDB" id="B8ML73"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
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        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="201"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED14988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="370" mass="40188" checksum="E88CC70045BFA5F0" modified="2009-03-03" version="1">MSPSATFPSESTAAPTASFPEVHIPSDKKAGLRTISLYQLQSGSASERNLLLETCMNDGFFYLDLSHPNFASLLAFVDATFNCSKELFNYPPEIKSLFDVDKISDLKVNGYKPKGRNVVGNGKDGKNDGFESWVLPRNGVLQLSNEPFPHPPVVANHLPDISGLFDGLSSAAHVILSSLSDSLSLPAGQRLEDFQGLNRPSPDILRVLKYHANSNTDIIPQTPHTDLGSLTFVFSTTPGLQVLPPGVQQKPGAYSESDWLYVEPRPGHAIVNIGDCITLMTNGILRSALHRVGPVTGCAMPERYSMAYLMRPEDQTVLRALDSPLIPKSTIGEDVVTSGAWIRKKFKALRGQKDAGNFDQILTGGRGILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLQ3</accession>
    <name>B8MLQ3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_098820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485863.1">
        <property type="nucleotide sequence ID" value="XM_002485818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLQ3"/>
    <dbReference type="GeneID" id="8099710"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_098820"/>
    <dbReference type="eggNOG" id="ENOG502SPA2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098382_0_0_1"/>
    <dbReference type="InParanoid" id="B8MLQ3"/>
    <dbReference type="OMA" id="KRHEVCW"/>
    <dbReference type="OrthoDB" id="2824656at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002875208" evidence="1">
        <location>
            <begin position="18"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="224" mass="25440" checksum="AFF5A0FE60DEEB82" modified="2009-03-03" version="1">MLLQLVRFTLLPSLTLAAPAVAQLRQHVSNAGASRQYLSYMMSTQSASLPKKRHEICWIILWHKNFTVANKPAVTGLDDIIQGTATTMLYDFDDSQLEQLTRGIEAPICEFAFIRLSPVAPLSDPGLRTSMHKTYTDCYKMQGFISGQWAYSIDANHPDGIPLSDNTLLKPDDRRLALYFLGWESIELHQDACLTPLFAEEIDKLQPWFYPGSGAWYNTFRQYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMC5</accession>
    <name>B8MMC5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xaa-Pro dipeptidyl-peptidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_099310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485917.1">
        <property type="nucleotide sequence ID" value="XM_002485872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMC5"/>
    <dbReference type="STRING" id="441959.B8MMC5"/>
    <dbReference type="GeneID" id="8104009"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_099310"/>
    <dbReference type="eggNOG" id="ENOG502RPGM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015590_3_0_1"/>
    <dbReference type="InParanoid" id="B8MMC5"/>
    <dbReference type="OMA" id="DIFREQF"/>
    <dbReference type="OrthoDB" id="2578740at2759"/>
    <dbReference type="PhylomeDB" id="B8MMC5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF10">
        <property type="entry name" value="COCE_NOND FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="2">
        <location>
            <begin position="326"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED13679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="595" mass="67589" checksum="B4EB9B1A1ED02A88" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMF1</accession>
    <name>B8MMF1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General amino acid permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_099570</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485943.1">
        <property type="nucleotide sequence ID" value="XM_002485898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMF1"/>
    <dbReference type="STRING" id="441959.B8MMF1"/>
    <dbReference type="GeneID" id="8105400"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_099570"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="InParanoid" id="B8MMF1"/>
    <dbReference type="OMA" id="ECLIGSA"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="PhylomeDB" id="B8MMF1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF18">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="41"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED13705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="538" mass="59555" checksum="A32524233AAB2E0D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQ04</accession>
    <name>B8MQ04_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_054050</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487005.1">
        <property type="nucleotide sequence ID" value="XM_002486960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQ04"/>
    <dbReference type="FunCoup" id="B8MQ04">
        <property type="interactions" value="1096"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MQ04"/>
    <dbReference type="GeneID" id="8100345"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_054050"/>
    <dbReference type="eggNOG" id="KOG0166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018084_6_0_1"/>
    <dbReference type="InParanoid" id="B8MQ04"/>
    <dbReference type="OMA" id="EMIQMLY"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="PhylomeDB" id="B8MQ04"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.690:FF:000003">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000021">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="10">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
            <begin position="124"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
            <begin position="166"/>
            <end position="208"/>
        </location>
    </feature>
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        <location>
            <begin position="335"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED12894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="552" mass="60559" checksum="263E590742A6D19D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQ16</accession>
    <name>B8MQ16_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_054180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487017.1">
        <property type="nucleotide sequence ID" value="XM_002486972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQ16"/>
    <dbReference type="STRING" id="441959.B8MQ16"/>
    <dbReference type="GeneID" id="8100357"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_054180"/>
    <dbReference type="eggNOG" id="ENOG502QW4G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035426_1_0_1"/>
    <dbReference type="InParanoid" id="B8MQ16"/>
    <dbReference type="OMA" id="YYDNQQW"/>
    <dbReference type="OrthoDB" id="5401193at2759"/>
    <dbReference type="PhylomeDB" id="B8MQ16"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED12906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="419" mass="44907" checksum="2281F78F8171D6B8" modified="2009-03-03" version="1">MSTSYYEPQGWQAPARQASWEQPVPPSRSGTSSVSQRDDSSAFSSQFDEVDRAIDNLVKSGKLFNGPRRESMPMMMMGRHFPEYDPRMAGGIPPQRHHSVSDFDQSRGHPGAALQGFYASQRFQGRQSETEQMLQAKRRMAAQRERELRNYHQEQQYNRSLLAEMSGNKPDRSLSPAAMSEESRRELIARQHRALYGNESPAFFAPGSLGEDAHNSRSDNTNTGTPTSVSGGVRGPSPRAVDPFGMSQSQEGLGQNSGSNPLPATGRQSPRANRTTSPNTGANSSYGLYENVNVEQPNTSNSSPGGADSPSSRQLSSKSAGHLGSVGPIGSRPSQPATSQAQNPALNKRSTTPLPSPLGFGFAPNESATTANERSNSSASNPTNSGHTNAKESAFSSGWGSNSGVWGSKNLGVQASVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQG1</accession>
    <name>B8MQG1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10 12">Alpha-glucuronidase</fullName>
            <ecNumber evidence="2 10 12">3.2.1.139</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">aguA</name>
        <name evidence="16" type="ORF">TSTA_058520</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 12">Alpha-glucuronidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Releases 4-O-methylglucuronic acid from xylan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10 12">
            <text>an alpha-D-glucuronoside + H2O = D-glucuronate + an alcohol</text>
            <dbReference type="Rhea" id="RHEA:20005"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="ChEBI" id="CHEBI:58899"/>
            <dbReference type="EC" id="3.2.1.139"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10 12">Belongs to the glycosyl hydrolase 67 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.139" evidence="2 10 12"/>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487474.1">
        <property type="nucleotide sequence ID" value="XM_002487429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQG1"/>
    <dbReference type="STRING" id="441959.B8MQG1"/>
    <dbReference type="GeneID" id="8106454"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_058520"/>
    <dbReference type="eggNOG" id="ENOG502QWS4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007125_2_0_1"/>
    <dbReference type="InParanoid" id="B8MQG1"/>
    <dbReference type="OMA" id="YNHHLDE"/>
    <dbReference type="OrthoDB" id="6501611at2759"/>
    <dbReference type="PhylomeDB" id="B8MQG1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046559">
        <property type="term" value="F:alpha-glucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02795">
        <property type="entry name" value="CBM6-CBM35-CBM36_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1330.10">
        <property type="entry name" value="Alpha-glucuronidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037054">
        <property type="entry name" value="A-glucoronidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011395">
        <property type="entry name" value="Glyco_hydro_67_aGlcAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005154">
        <property type="entry name" value="Glyco_hydro_67_aGlcAse_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011099">
        <property type="entry name" value="Glyco_hydro_67_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011100">
        <property type="entry name" value="Glyco_hydro_67_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39207">
        <property type="entry name" value="ALPHA-GLUCURONIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39207:SF1">
        <property type="entry name" value="ALPHA-GLUCURONIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07477">
        <property type="entry name" value="Glyco_hydro_67C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07488">
        <property type="entry name" value="Glyco_hydro_67M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03648">
        <property type="entry name" value="Glyco_hydro_67N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029900">
        <property type="entry name" value="Alpha-glucuronds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 12" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="Alpha glucuronidase N-terminal" evidence="13">
        <location>
            <begin position="10"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 67 catalytic" evidence="15">
        <location>
            <begin position="137"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 67 C-terminal" evidence="14">
        <location>
            <begin position="462"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR029900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR029900-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EED13363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="833" mass="92321" checksum="D5B0BF6A6BD68C0C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQS0</accession>
    <name>B8MQS0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_052400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486828.1">
        <property type="nucleotide sequence ID" value="XM_002486783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQS0"/>
    <dbReference type="STRING" id="441959.B8MQS0"/>
    <dbReference type="GeneID" id="8098189"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_052400"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_10_0_1"/>
    <dbReference type="InParanoid" id="B8MQS0"/>
    <dbReference type="OMA" id="WARDVHA"/>
    <dbReference type="OrthoDB" id="4159828at2759"/>
    <dbReference type="PhylomeDB" id="B8MQS0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="185" mass="21165" checksum="3A8592A61770E824" modified="2009-03-03" version="1">MEEIERKVFEAKPWKAPGEDGLLAMMWRQLWLVVKERIIPLKKPAKDNYSLAKSWRPISLLSTLGKILEVVIAERISYAAETFSLLPTNHFGARKRRSAEQAILLLQEEIYKAWRNRKVLSLVSFDVAGAYNGVFKERLLQRLKARGIPDKMVQWIDAFCSGRTATITVNGQISEQRELLQAGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRJ8</accession>
    <name>B8MRJ8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-ribose-5-phosphate ketol-isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoriboisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_056560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487266.1">
        <property type="nucleotide sequence ID" value="XM_002487221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRJ8"/>
    <dbReference type="FunCoup" id="B8MRJ8">
        <property type="interactions" value="906"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MRJ8"/>
    <dbReference type="GeneID" id="8100719"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_056560"/>
    <dbReference type="eggNOG" id="KOG3075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056590_0_0_1"/>
    <dbReference type="InParanoid" id="B8MRJ8"/>
    <dbReference type="OMA" id="ACHVQEK"/>
    <dbReference type="OrthoDB" id="1555531at2759"/>
    <dbReference type="PhylomeDB" id="B8MRJ8"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006014">
        <property type="term" value="P:D-ribose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000014">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934:SF0">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED13155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="326" mass="35134" checksum="0C0D737C7F153391" modified="2009-03-03" version="1">MKPFLRLFSSPREFSIRYRTTCVSKSNPSAFGFLATPCRQTYRSFFASRSKHTMAASIEASKRAAAKVAVQNHYPLNAKWVGIGSGTTIVYVVEAIKELGIDTSLTRFVPTGYQSKQLIKQAGLTAVEFDALPEDVVLDVAFDGADEVDDDLNCIKGGGACLFQEKIVALQAKEFICVADSRKLQNRLLTNWKYIPIEVAPIAANRVIRKLTELGSIKPAIRLNTVAKEGPLKTDQGFFIVDAPFLPLLTPSDVKAGKDGNGTDGVWEVETLANKIKAIPGVLEVGIFCGVTGPEAQSLGSTGGQKPVAAYFGMPDGTVTVRKAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRW6</accession>
    <name>B8MRW6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_057890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487411.1">
        <property type="nucleotide sequence ID" value="XM_002487366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRW6"/>
    <dbReference type="STRING" id="441959.B8MRW6"/>
    <dbReference type="GeneID" id="8108925"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_057890"/>
    <dbReference type="eggNOG" id="KOG0730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1316185_0_0_1"/>
    <dbReference type="InParanoid" id="B8MRW6"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="PhylomeDB" id="B8MRW6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED13300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="209" mass="23501" checksum="755C2305B5B75A76" modified="2009-03-03" version="1">MVSLFKQDYLRELNETKPRNLPLNQLFVGNPGKGKTTAPALYGRILVDLGLLSKGDGKLFYYLGLDCGACGAVNVTDEPFTSISGGKPVRFEDFSFARLEQILLWKISQQETACSSDAIQVAKDMLERALTRPNFGNASEVERCLSIAKLNYEKRQYKAVGCEDASQDEEFLPEDFDLEHKHRHINCHELLAEKLDDQIIEPISSFHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8MS19</accession>
    <name>B8MS19_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial export protein Som1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_002630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487851.1">
        <property type="nucleotide sequence ID" value="XM_002487806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MS19"/>
    <dbReference type="GeneID" id="8102874"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_002630"/>
    <dbReference type="eggNOG" id="ENOG502SG5C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142986_2_0_1"/>
    <dbReference type="InParanoid" id="B8MS19"/>
    <dbReference type="OMA" id="TTSWEPI"/>
    <dbReference type="OrthoDB" id="3983163at2759"/>
    <dbReference type="PhylomeDB" id="B8MS19"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024645">
        <property type="entry name" value="Mitochondr_Som1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11093">
        <property type="entry name" value="Mitochondr_Som1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="12196" checksum="43358A2687DCE37A" modified="2009-03-03" version="1">MAPLVPIFPTDDLQSRVQIIHRGFKEKRRKGEPIDLHKCELMEMVQYSCNPPEEGILPPGVVMCKPIVRLFRRCAGGLTVETTSWEKMNANNEASSNKLDTRKEKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B8MS26</accession>
    <name>B8MS26_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_002700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487858.1">
        <property type="nucleotide sequence ID" value="XM_002487813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MS26"/>
    <dbReference type="STRING" id="441959.B8MS26"/>
    <dbReference type="GeneID" id="8102881"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_002700"/>
    <dbReference type="HOGENOM" id="CLU_1971961_0_0_1"/>
    <dbReference type="InParanoid" id="B8MS26"/>
    <dbReference type="OrthoDB" id="5358884at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="127" mass="13178" checksum="CCBECA6724E53D70" modified="2009-03-03" version="1">MPGASQSYSSTSSSTTFTSHSSTRTSRSASTPAAITDCPTSNGTTYTPGNPSSGNSIYQFTKKAADTTTDGTNLEQASLSTFNGSESRVGIQCTSVVHLMDTSCYAKNGTKTVKSMYNDVVVAMLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MS76</accession>
    <name>B8MS76_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acid phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_002010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="2"/>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487788.1">
        <property type="nucleotide sequence ID" value="XM_002487743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MS76"/>
    <dbReference type="STRING" id="441959.B8MS76"/>
    <dbReference type="GeneID" id="8098792"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_002010"/>
    <dbReference type="eggNOG" id="ENOG502QSRP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027977_2_0_1"/>
    <dbReference type="InParanoid" id="B8MS76"/>
    <dbReference type="OMA" id="GYVNWEV"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="PhylomeDB" id="B8MS76"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000043">
        <property type="entry name" value="Acid phosphatase PHOa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF23">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877745" description="acid phosphatase" evidence="4">
        <location>
            <begin position="24"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED12134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="417" mass="46285" checksum="09CEEAD9DCD08B0F" modified="2009-03-03" version="1">MLSQKMLYNILLAMMATCSLTAAQTTTEQYPSAAEIAAAQASVVPYSPVSKVHGKVFSRFVDIWLENTDLETAEAESHLAELKKNGIFLSNYWAVTHPSEPNYCAAAGGDHFGMDNDDWHQIPNNVSTIADLFDTKKLSWAEYQEALPYAGYQGFRYPESGPNNYVRKHNPLILFNSVTDDATRLRQIKNFTSFYDDLDNQRLPQYSFITPNMTNDGHDTNVAFSGTWSYNFLGELFKNECFMEDTLVLLTFDENGNKTHPNKVYSLLVGGAVPDHLKGTTDDTFYTHYSVIASLSANFDLPSLGRWDCGANLLSIVADKTGYINYDVDTSNFNLNTSYPGPLSNKAFSAAWPVPLTTGTCSGGRSILNTVKQTYHGLKPTYNYTSPVPYDAVSGTAVGVKYSRTGHNGKTEWYETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSG7</accession>
    <name>B8MSG7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_000390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED11962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487616.1">
        <property type="nucleotide sequence ID" value="XM_002487571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSG7"/>
    <dbReference type="GeneID" id="8108662"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_000390"/>
    <dbReference type="eggNOG" id="KOG2551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051938_4_0_1"/>
    <dbReference type="InParanoid" id="B8MSG7"/>
    <dbReference type="OMA" id="LPTVHIW"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="PhylomeDB" id="B8MSG7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF7">
        <property type="entry name" value="SERINE HYDROLASE FSH DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED11962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="219" mass="24153" checksum="73C1F079F15A314D" modified="2009-03-03" version="1">MKFLCLHGNGTNSNIMRMQTASLRYELEDGHEYEFVEAAIPATMSQGIETFSTPDQSFYAFYNPEELSTLQVTIAQLDEYITAEGPFDVVMGFSAGAVLAASYILQKQQQQGHDTPPFKCGIFLSSALSAAEMNYLGWLHSDDNDEGGHLTIRLPTVHIWGANDQTAPTGGADLSKLCDPAQRLIVIHDGTHELPRGEHMTQAVHAIRRALYAASQYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSI3</accession>
    <name>B8MSI3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_000830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487665.1">
        <property type="nucleotide sequence ID" value="XM_002487620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSI3"/>
    <dbReference type="STRING" id="441959.B8MSI3"/>
    <dbReference type="GeneID" id="8108706"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_000830"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_13_1"/>
    <dbReference type="InParanoid" id="B8MSI3"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="PhylomeDB" id="B8MSI3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="360"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED12011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="409" mass="45380" checksum="EA08A2760A902F3C" modified="2009-03-03" version="1">MSNPNDYTVGWICALSTEYVAAQEFLDDEHALLDFVSPNDTNDYTLGRLGKHNVVIAVLPDGEYGTASAATVATNMLNSFLNARIGLMVGIGGGALSRKHDIRLGDIVVSAPRDGEGGVLEYNFAQHKRKGHQGEDAIGFVLEKNPRLCQEYARPQPNTDKLFHPHAIHNSRACGFCVHNPSYVVERRERAEHEDNPAIHYGLVASANQLMKDAVIRDRLAAEKGVLCFEMEAAGLMNHFLCLVIRGICDYSDSHKNKEWQGYAAMTAAAYAKDLLSRISPNRVEAEKRISDVLSLVRKDIKEVHTTAQNTKTAIEILDNDRRREKVIAKLPYAKGSTFDSFDGVLDPRCHPETRIALRRQIREWAENGQGKSIFWLKGIAGTGKSTISRTVAESLHMEGKLGASFFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSY4</accession>
    <name>B8MSY4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CobW domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_002240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487811.1">
        <property type="nucleotide sequence ID" value="XM_002487766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSY4"/>
    <dbReference type="STRING" id="441959.B8MSY4"/>
    <dbReference type="GeneID" id="8102835"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_002240"/>
    <dbReference type="eggNOG" id="KOG2743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017452_2_1_1"/>
    <dbReference type="InParanoid" id="B8MSY4"/>
    <dbReference type="OMA" id="WSQAGPN"/>
    <dbReference type="OrthoDB" id="272672at2759"/>
    <dbReference type="PhylomeDB" id="B8MSY4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051927">
        <property type="entry name" value="Zn_Chap_cDPG_Synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43603">
        <property type="entry name" value="COBW DOMAIN-CONTAINING PROTEIN DDB_G0274527"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43603:SF1">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90002">
        <property type="entry name" value="Hypothetical protein YjiA, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="2">
        <location>
            <begin position="303"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED12157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="565" mass="63908" checksum="B33F0F6E757D7CE6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8MT14</accession>
    <name>B8MT14_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_001100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002487647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MT14"/>
    <dbReference type="STRING" id="441959.B8MT14"/>
    <dbReference type="GeneID" id="8108733"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_001100"/>
    <dbReference type="HOGENOM" id="CLU_197760_0_0_1"/>
    <dbReference type="InParanoid" id="B8MT14"/>
    <dbReference type="OrthoDB" id="4772102at2759"/>
    <dbReference type="PhylomeDB" id="B8MT14"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED12038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="9102" checksum="3266F9F73A4955BE" modified="2009-03-03" version="1">MFMRMPPGYRTLINLEFKAIPQEPCCMLKSGIILFFYVDDIVVAYKKDREAEAKSVMKELCAKYHITSGEDLEWFLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTB9</accession>
    <name>B8MTB9_TALSN</name>
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        <submittedName>
            <fullName evidence="6">Ankyrin repeat-containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_004180</name>
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    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002487978.1"/>
    </dbReference>
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    <dbReference type="STRING" id="441959.B8MTB9"/>
    <dbReference type="GeneID" id="8100129"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_004180"/>
    <dbReference type="eggNOG" id="KOG0502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001887_0_0_1"/>
    <dbReference type="InParanoid" id="B8MTB9"/>
    <dbReference type="OMA" id="CFAFHLE"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="PhylomeDB" id="B8MTB9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002875359" evidence="5">
        <location>
            <begin position="27"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="957"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="990"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1023"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1056"/>
            <end position="1088"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED12369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1124" mass="125589" checksum="44448399347A5EE4" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTF8</accession>
    <name>B8MTF8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS drug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_003480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487944.1">
        <property type="nucleotide sequence ID" value="XM_002487899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTF8"/>
    <dbReference type="FunCoup" id="B8MTF8">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="GeneID" id="8098044"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_003480"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_3_1"/>
    <dbReference type="InParanoid" id="B8MTF8"/>
    <dbReference type="OMA" id="TATITFM"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="PhylomeDB" id="B8MTF8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000022">
        <property type="entry name" value="MFS drug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000670">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF81">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="47"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED12290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="492" mass="53257" checksum="FE86A49B04F7EFAC" modified="2009-03-03" version="1">MAIEESNSFVLSDSRTSDDIEQLSEFQTLLRQHEQAKWKPPKGFVWIQVAIFANVFLSGFDGTITVSTYALISSEFNAANTASWLTTSYLITSTAFQPIYGRMSDIFGRKPCFYVCTIAFLLGCLGCGVAQDMFLLNIMRAITGVGGGGLITMATIINSDLIPFKNRGMYQAAQNVLHGFGAICGASLGGAIAETIGWRWCFLLQVPLSVFALVVGKIVIRLPQTSEDHNSTHGWQGIWNQVDILGTMLLVSGLSVQLIGLSLGGNELPWSNPWIILSLTGSVALLALFLWTEARTLAAPIIPLRLLHGTVPICIQIANLCVGMGAYAFLFNLPLFFQVVLLDSASTAGARLVIPSLATPLGGLIAGIIMSRWGRLSQIVQTGALLMFVGNLLVAMLRFNDASWKYFVYVFPANLGQGMVYPGILFSFLAAFDHTDHAVSSSTVYLIRSLGNVWGVAITSAVVQNQLNSGLSKALSGIPDHRKVKPFIFRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTY7</accession>
    <name>B8MTY7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="10">PPIase</shortName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_006430</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488274.1">
        <property type="nucleotide sequence ID" value="XM_002488229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTY7"/>
    <dbReference type="STRING" id="441959.B8MTY7"/>
    <dbReference type="GeneID" id="8105328"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_006430"/>
    <dbReference type="eggNOG" id="KOG0415">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018791_2_1_1"/>
    <dbReference type="InParanoid" id="B8MTY7"/>
    <dbReference type="OMA" id="APKCCEN"/>
    <dbReference type="OrthoDB" id="2083at2759"/>
    <dbReference type="PhylomeDB" id="B8MTY7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01921">
        <property type="entry name" value="cyclophilin_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12235">
        <property type="entry name" value="RRM_PPIL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000015">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000377">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035542">
        <property type="entry name" value="CRIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035538">
        <property type="entry name" value="Cyclophilin_PPIL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="12">
        <location>
            <begin position="6"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="248"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="341"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="353"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="410"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED12620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="455" mass="52286" checksum="A00CFD299B4BE69B" modified="2009-03-03" version="1">MSVLLETSLGDLVIDLLVDVAPKACENFLKLCKVKYYNFSPVHSVQKNFTFQTGDPIGPGSPDSDGGSSIWGLLKGRTHKTFAVDMPPKLKHTERGTVSMATVPSPKDPDERLAGSQFIVTLGDNLDYLDGKAAIFGKVVEGFDVLEKINEVFIDDNGRPLKDIRIRHTVVLDDPYDDPPGLEVPPESPLPSKAQLATVRIADDEELDENIDEEAMEKLRREREARAQALTLEMVGDLPFAEVKPPENVLFVCKLNPVTQDEDLHLIFSRFGPILSCEVIRDKRTGDSLQYAFIEFENQKDCEQAYFKMEGVLIDDHRIHVDFSQSVSKLSDTWRQATVQKRQGGGFGGISSLERKRQYRTAEDRGRPDRYGMVFDKDEMRRPPPSRDEKPLRRSHSRSRSPKIRGPAPRRFDDQHRDDRYRDGRNRDRDRDRDRDRNRNRDRYTPDRRDYDRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTZ4</accession>
    <name>B8MTZ4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">mRNA binding post-transcriptional regulator (Csx1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_006490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488281.1">
        <property type="nucleotide sequence ID" value="XM_002488236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTZ4"/>
    <dbReference type="FunCoup" id="B8MTZ4">
        <property type="interactions" value="158"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MTZ4"/>
    <dbReference type="GeneID" id="8105334"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_006490"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8MTZ4"/>
    <dbReference type="OMA" id="VRIFKMQ"/>
    <dbReference type="OrthoDB" id="446113at2759"/>
    <dbReference type="PhylomeDB" id="B8MTZ4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12611">
        <property type="entry name" value="RRM1_NGR1_NAM8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12613">
        <property type="entry name" value="RRM2_NGR1_NAM8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12346">
        <property type="entry name" value="RRM3_NGR1_NAM8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000065">
        <property type="entry name" value="mRNA binding post-transcriptional regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000222">
        <property type="entry name" value="mRNA binding post-transcriptional regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000227">
        <property type="entry name" value="mRNA binding post-transcriptional regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF10">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="59"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="153"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="281"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED12627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="393" mass="42002" checksum="5F6D7419D8D35226" modified="2009-03-03" version="1">MSFQNYEYQNQQDGAASAGAPAPADTTMTGQADPSPAPFAGTPGEPSAAATQQGGDGKTTLWMGELEPWIDENFIRNLWFQMGEQVNVKMIRDKFSGSNAGYCFVDFASPAAAAKALSLNGTPMPNTTRAFKLNWATGGGLADRGRDERGPEYSIFVGDLGPEVNEYVLVSLFQSRFPSCKSAKIMTDPISGMSRGYGFVRFSDENDQQRALSEMQGVYCGNRPMRISTATPKNKGPGVGPGGMGMPGPAGIYPPAAMGGPPMGFYGAPQPMNQFTDPNNTTVFVGGLSGYVTEDELRSFFQGFGEITYVKIPPGKGCGFVQFVQRHAAEMAINQMQGYPIGNSRVRLSWGRSQNNSGPAGTPYRPAPPPPIYPNMGMPPAHQYGGGFAPMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8MU06</accession>
    <name>B8MU06_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_006590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488293.1">
        <property type="nucleotide sequence ID" value="XM_002488248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MU06"/>
    <dbReference type="STRING" id="441959.B8MU06"/>
    <dbReference type="GeneID" id="8105344"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_006590"/>
    <dbReference type="eggNOG" id="KOG2497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038942_1_2_1"/>
    <dbReference type="InParanoid" id="B8MU06"/>
    <dbReference type="OMA" id="PIRTYRI"/>
    <dbReference type="OrthoDB" id="194386at2759"/>
    <dbReference type="PhylomeDB" id="B8MU06"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF130">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED12639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="40125" checksum="2AC62B29ED7DB0B4" modified="2009-03-03" version="1">MESITETKDVLRLIAQYFELVELRSLSIPSSSVLKNSITQNRIYNEMFNEELLSPVIPPATYRLRLLKRLIFVIESDPRWDPEEDEIIEPLIAAMIDLMSQPAEESSSMSLDTEEPQLSFVSYTVPQAELQERKQVVTFESRGLIYGSGSTGFRTWEAALHLGTYLSSTSCGGSSPVSVQGKRVVELGAGTGFISLLCQKFLGAAKVLMTDGNSKLVDVFNRPCLEQNGFGRSNGSIEGRQWVWGDPLSTNGTEQQFDIALGADLIYDKAIIPLLIDAISLLFSSHGVRQFVISATIRNQDTFSAFLNACRPDFDIYHITFVLILGSTILVTIESNIPSADSSLEELKSTPSMQMEKCLPISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUC1</accession>
    <name>B8MUC1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_108140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488381.1">
        <property type="nucleotide sequence ID" value="XM_002488336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUC1"/>
    <dbReference type="STRING" id="441959.B8MUC1"/>
    <dbReference type="GeneID" id="8106878"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_108140"/>
    <dbReference type="HOGENOM" id="CLU_1023697_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUC1"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="PhylomeDB" id="B8MUC1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="272" mass="30029" checksum="5F8252BA05B70A97" modified="2009-03-03" version="1">MITRCRKRLLNLARHQTNLPMNFNDTRVSLAQKASTTPMSEPKSEENTSKSKATTFEMKGLPLNMKDLPASSIIPSDRASSTAASEAIHIDAQSSSKSFKYIILSEEVAENRIKGSSKYNIGWICATSTKYVAAKGLLDKEHESLEYGSADDNNFDTLGEMEKHKVVIPRLPKWEYEFAAAASVARDMARTFPHVQIGLMVGIGGGAPSKKHDIRISPTASGGLHNHVLVKNKWVARNDTNVIWLTAEYRASYSAVSWGMLILGQLTFLKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUL5</accession>
    <name>B8MUL5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_108690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488439.1">
        <property type="nucleotide sequence ID" value="XM_002488394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUL5"/>
    <dbReference type="STRING" id="441959.B8MUL5"/>
    <dbReference type="GeneID" id="8103125"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_108690"/>
    <dbReference type="eggNOG" id="ENOG502SCIP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010004_1_0_1"/>
    <dbReference type="InParanoid" id="B8MUL5"/>
    <dbReference type="OrthoDB" id="4464205at2759"/>
    <dbReference type="PhylomeDB" id="B8MUL5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="449"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="599"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="556"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="640"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED11683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="654" mass="72514" checksum="DC17AA99CDDFBD26" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUP0</accession>
    <name>B8MUP0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_108890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488464.1">
        <property type="nucleotide sequence ID" value="XM_002488419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUP0"/>
    <dbReference type="STRING" id="441959.B8MUP0"/>
    <dbReference type="GeneID" id="8103145"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_108890"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_3_1_1"/>
    <dbReference type="InParanoid" id="B8MUP0"/>
    <dbReference type="OMA" id="NILCENQ"/>
    <dbReference type="OrthoDB" id="4510570at2759"/>
    <dbReference type="PhylomeDB" id="B8MUP0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="43"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED11708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="365" mass="40956" checksum="A4115360E505BEF5" modified="2009-03-03" version="1">MAQVEKSILKARNTAPGEDKLQTNILKTAWPLIKDKILFLFQGCLRLGYHPKCFRHAILTILQKPSKEDWTNPRSYRPIALLSVLGKGLERLVARNMAWIAIHYKVLASQQFGALPLRSVINLTTCLTHNIEQALNQGKTASLLTFDVEGAFDNVLPGRLTYQLQTQGWPNNLILWISSFITERTIQIRFDNELSPHTDISCGLPQGSPISPILFMLYIAPLFHMGNPRTRFGHADDGATLAISLSLLTNYQTLSESLQDAIEWGTAEGITFAPNKYELMHFSWHRADQDPATTPSVSMGSVIVTEATDRPYLRWLGILFDKKLSFHWPYRPVSSVKPTSAQRRGGQAAPDLVPALRQTLPQSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUW5</accession>
    <name>B8MUW5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_109120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488489.1">
        <property type="nucleotide sequence ID" value="XM_002488444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUW5"/>
    <dbReference type="GeneID" id="8107144"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109120"/>
    <dbReference type="HOGENOM" id="CLU_811766_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUW5"/>
    <dbReference type="PhylomeDB" id="B8MUW5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="342" mass="35753" checksum="411E06B2168912A4" modified="2009-03-03" version="1">MGLFNSDYSRLPTNTSDKTGVLESPMETSDDPWNSPFGEPPIRSALESDEVPAFGKLPGAPENFTSILKFDGVPAFGKSPGAPENFTSALGSNEVPAFGKLPGAPKNFTSILFNEVPAFGKSPGAPENSTSALGSNEVPAFGKLPGAPKNFTSILFNEVPAFGKSPGAPENSTSALGSNEVPAFGKLPGAPKNFTSILFNEVPAFGKSPGAPENSTSALGSNEVPAFGKLPGAPKNFTSILFNEVPAFGKSPGAPENSTSALGSNEVPAFGEPSRPPKKNIRSTFRSPKTSNDSRQNDSSFSDPHHGSMIVEYSPFASWGPRVPPFVVPISPKDIPNLKRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MVA3</accession>
    <name>B8MVA3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_008550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962662">
        <property type="protein sequence ID" value="EED11559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488740.1">
        <property type="nucleotide sequence ID" value="XM_002488695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MVA3"/>
    <dbReference type="STRING" id="441959.B8MVA3"/>
    <dbReference type="GeneID" id="8103243"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_008550"/>
    <dbReference type="eggNOG" id="KOG1121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009123_10_2_1"/>
    <dbReference type="InParanoid" id="B8MVA3"/>
    <dbReference type="OMA" id="RTISWER"/>
    <dbReference type="OrthoDB" id="4505704at2759"/>
    <dbReference type="PhylomeDB" id="B8MVA3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="6">
        <location>
            <begin position="422"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED11559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="512" mass="59076" checksum="E024E10C557F176C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MVB5</accession>
    <name>B8MVB5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_008670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962662">
        <property type="protein sequence ID" value="EED11571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488752.1">
        <property type="nucleotide sequence ID" value="XM_002488707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MVB5"/>
    <dbReference type="GeneID" id="8103255"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_008670"/>
    <dbReference type="HOGENOM" id="CLU_013929_8_1_1"/>
    <dbReference type="InParanoid" id="B8MVB5"/>
    <dbReference type="OrthoDB" id="4230268at2759"/>
    <dbReference type="PhylomeDB" id="B8MVB5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="39"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED11571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="192" mass="22282" checksum="4F50CA1C0BC3899E" modified="2009-03-03" version="1">MPSEKYKEEENRISEALEILRKNPGQKIKPLARGTSQLNRRPTHKRLTEDQERAIILWMNDLDDRGIPPTVRMIKNYADKVLQNMHPGADNPPQLGDRWVYRFLKRLPKEYVKMKQKTIDPKRHLAEDPSFIQAWFDRLETAIERYKITPSNIWNFDKSGFQIGQGGDEEVVTRYHGTTAIQVDVGTALGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8MVC4</accession>
    <name>B8MVC4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_008760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962662">
        <property type="protein sequence ID" value="EED11580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488761.1">
        <property type="nucleotide sequence ID" value="XM_002488716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MVC4"/>
    <dbReference type="GeneID" id="8103264"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_008760"/>
    <dbReference type="HOGENOM" id="CLU_556192_0_0_1"/>
    <dbReference type="InParanoid" id="B8MVC4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="491" mass="55516" checksum="204A6D0F2E98EB9E" modified="2009-03-03" version="1" fragment="single">VSRTRAMAIDLERKQSFEPKLQSTITKYGIPTEDIYTILTRLALQVGMGRDQYIVTRELKKRIYIPLNTNREYITVVEGVNASSEWVISPFVIIAAKTIIQGWFDATGYGQNIGIAVSGNGYPDDELGYQWIHRETFRKVKGWPNIDCQFVMDLALTLLPNPWARLVRTNPDYPTVARYKALAREPWQRHPLAAATIICGNCFGEGCRSRTYGLVNQRRWVPNGGPKDSRYHFSYPPPGKAASSAQLCEQDEKRRQKFHRLLRLFVTEKLTQSTVKLLLGERPLGEIGIDISLRAKEAGGNRWQFHLPASDNPIRHYVKVELAKAFRKRLIKGPKVYALMEYNPLLNKTSSRDSKDALPSALREYADVFSPQNEGQSTLSVVMGRAVISKRTSRKASSDRQKVQLHHRSYSYQRRTDLTKSPLRASVRYPSSLIDKAVGSTPTPLTKTITTNYRGSCKAFALRTAPILGNPFKNHPTHPRDRTPEASLASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>H9CNM6</accession>
    <name>H9CNM6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Intron-encoded GIY-YIG endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_m0430</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="2"/>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="BMC Genomics" volume="13" first="698" last="698">
            <title>Sequencing of mitochondrial genomes of nine Aspergillus and Penicillium species identifies mobile introns and accessory genes as main sources of genome size variability.</title>
            <authorList>
                <person name="Joardar V."/>
                <person name="Abrams N.F."/>
                <person name="Hostetler J."/>
                <person name="Paukstelis P.J."/>
                <person name="Pakala S."/>
                <person name="Pakala S.B."/>
                <person name="Zafar N."/>
                <person name="Abolude O.O."/>
                <person name="Payne G."/>
                <person name="Andrianopoulos A."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="23234273"/>
            <dbReference type="DOI" id="10.1186/1471-2164-13-698"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="JQ354994">
        <property type="protein sequence ID" value="AFD95920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9CNM6"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_m0430"/>
    <dbReference type="InParanoid" id="H9CNM6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="120"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFD95920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="242" mass="27515" checksum="164B163E063F0311" modified="2012-05-16" version="1">MFYKNLINLKPTNILKFNSNGSFNNNSSDPNQKNKWKIILGRSGTNQLVHKLALEHIKSGKPVTAKVINSILSYCNIEITESILKDILSKPGFVFDNLDTNETINDIEAIIGSPSKKIQIPGVYIFTHKLTGDKYVGSSSQLAIRLNGYLKNKHRVIGLLLPQLKENLDKFTLRIIPLNDNYAFRSEIVLEQYYLLDSSFNLNTVKVANNPSGSNAKPLYMYNREKLFYITFQCNKKILLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8LSW2</accession>
    <name>B8LSW2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_064270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPAT/DAPAT family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340345.1">
        <property type="nucleotide sequence ID" value="XM_002340304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LSW2"/>
    <dbReference type="STRING" id="441959.B8LSW2"/>
    <dbReference type="GeneID" id="8102481"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_064270"/>
    <dbReference type="eggNOG" id="KOG3730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015023_0_0_1"/>
    <dbReference type="InParanoid" id="B8LSW2"/>
    <dbReference type="OMA" id="ENMICKM"/>
    <dbReference type="OrthoDB" id="10255570at2759"/>
    <dbReference type="PhylomeDB" id="B8LSW2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07993">
        <property type="entry name" value="LPLAT_DHAPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022284">
        <property type="entry name" value="GPAT/DHAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045520">
        <property type="entry name" value="GPAT/DHAPAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041728">
        <property type="entry name" value="GPAT/DHAPAT_LPLAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563:SF17">
        <property type="entry name" value="DIHYDROXYACETONE PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19277">
        <property type="entry name" value="GPAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="6">
        <location>
            <begin position="212"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED22958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="816" mass="91132" checksum="9DD229F72699F5F7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8LSW8</accession>
    <name>B8LSW8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_064330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340351.1">
        <property type="nucleotide sequence ID" value="XM_002340310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LSW8"/>
    <dbReference type="STRING" id="441959.B8LSW8"/>
    <dbReference type="GeneID" id="8106611"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_064330"/>
    <dbReference type="eggNOG" id="ENOG502S3WP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061619_0_0_1"/>
    <dbReference type="InParanoid" id="B8LSW8"/>
    <dbReference type="OMA" id="DCPTFTT"/>
    <dbReference type="OrthoDB" id="5394411at2759"/>
    <dbReference type="PhylomeDB" id="B8LSW8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024624">
        <property type="entry name" value="Pyridox_Oxase_Alr4036_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243">
        <property type="entry name" value="AGL049CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE ALR4036 FAMILY FMN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12766">
        <property type="entry name" value="Pyridox_oxase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding" evidence="2">
        <location>
            <begin position="49"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED22964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="299" mass="33978" checksum="A3D81910ACFD34F0" modified="2009-03-03" version="1">MNRIINQAERKSKLALAATKYRSRRLQHHISHLSTHTGTMAATSSIPPAPWRSLFLEHISKLDDPYMSVSTVAFDPKTGIPLPRVRTCGFRGFFGELKLHHSAEKQLKDEGGLNPSIYESDMIAFTTDVRMEKVEQIKETGGAIEVLFWVKEVMGQWRLRGQAFVIGDSESEASEKAARSEVEKGLRKKSDNTGGSGEWSWEKEVTAYFANHSPLMRGSFKGPHPGTPHSQKPDDPNLSLGQKVKDLHDPVARRHFRVVVIRVEEVDRLDLNDPEKALRWKTTLDHTGHQRWEELELWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTF7</accession>
    <name>B8LTF7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-amino acid oxidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_064960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340422.1">
        <property type="nucleotide sequence ID" value="XM_002340381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTF7"/>
    <dbReference type="STRING" id="441959.B8LTF7"/>
    <dbReference type="GeneID" id="8108616"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_064960"/>
    <dbReference type="eggNOG" id="KOG3923">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1046543_0_0_1"/>
    <dbReference type="InParanoid" id="B8LTF7"/>
    <dbReference type="OrthoDB" id="409956at2759"/>
    <dbReference type="PhylomeDB" id="B8LTF7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF16">
        <property type="entry name" value="D-AMINO ACID OXIDASE (AFU_ORTHOLOGUE AFUA_5G11290)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="34"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED23035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="266" mass="29602" checksum="9DECE64933195910" modified="2009-03-03" version="1">MVIWHLVRSGRVFPKIHLDHQIRIEDFAKDRRTHSTYEFTTVCINTAIYLPWLLSKCLGNGVAFKRAVVEHVTDAACLHENPGHVGQVVVVRNDPGVMTTVSNTTSGQNAMVYMMCRPGGKSFEYTPTSVERKIDTRHTGGGSILGGCYQVNNWEESPDTDLAENIKRGCVTLYPALTQGQGVDELSIIRHGVGFRPLRPQGVRIETEYIRGIPVVHNYGHGGWGYQSSYGCTSASQNAKFLNLCKGLLLFSLFLTKKRKSFIKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTG8</accession>
    <name>B8LTG8_TALSN</name>
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        <submittedName>
            <fullName evidence="6">MYB DNA binding protein (Tbf1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_065060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340433.1">
        <property type="nucleotide sequence ID" value="XM_002340392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTG8"/>
    <dbReference type="FunCoup" id="B8LTG8">
        <property type="interactions" value="455"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LTG8"/>
    <dbReference type="GeneID" id="8102310"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_065060"/>
    <dbReference type="eggNOG" id="ENOG502QRT9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008791_1_0_1"/>
    <dbReference type="InParanoid" id="B8LTG8"/>
    <dbReference type="OMA" id="YMPGVPH"/>
    <dbReference type="OrthoDB" id="3366990at2759"/>
    <dbReference type="PhylomeDB" id="B8LTG8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000137">
        <property type="entry name" value="MYB DNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013867">
        <property type="entry name" value="Telomere_rpt-bd_fac_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052833">
        <property type="entry name" value="Telomeric_DNA-bd_trans-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47807">
        <property type="entry name" value="PROTEIN TBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47807:SF1">
        <property type="entry name" value="PROTEIN TBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08558">
        <property type="entry name" value="TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="5">
        <location>
            <begin position="632"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="430"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="481"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="713"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="488"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="721"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="770"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED23046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="824" mass="91163" checksum="7D3EAAC3E9DCEDEE" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8LU17</accession>
    <name>B8LU17_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_072400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341234.1">
        <property type="nucleotide sequence ID" value="XM_002341193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LU17"/>
    <dbReference type="GeneID" id="8101133"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_072400"/>
    <dbReference type="HOGENOM" id="CLU_1344035_0_0_1"/>
    <dbReference type="InParanoid" id="B8LU17"/>
    <dbReference type="OrthoDB" id="4365667at2759"/>
    <dbReference type="PhylomeDB" id="B8LU17"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED23847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="204" mass="22649" checksum="4A1E45EA741E47CA" modified="2009-03-03" version="1">MQRAMIAKRNNREKGWPDFVKACSLTANRLEQISLNEDRVKGRAANPHGTTPLLSTRASIPITTAASPLNNNSQYHSGNRLTKKARALLIKEGKCFKCKMLGHIGKDCPNTPNRSTELKELEKLIGREKDSLTISVQVAKNTHSISAKALTDTGANGLAFMDIHFAILLSEFLQVRTHRMELDCAIRGYDRKEASPITHAIVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8LU43</accession>
    <name>B8LU43_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_060130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002339902.1">
        <property type="nucleotide sequence ID" value="XM_002339861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LU43"/>
    <dbReference type="GeneID" id="8108536"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_060130"/>
    <dbReference type="eggNOG" id="ENOG502RNV9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_633365_0_0_1"/>
    <dbReference type="InParanoid" id="B8LU43"/>
    <dbReference type="OMA" id="GWENNST"/>
    <dbReference type="OrthoDB" id="4224113at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="433" mass="47197" checksum="2F816C011C5A0F34" modified="2009-03-03" version="1">MYTRALSSIALVMDRFKSSPLYPIEEVTPVDHQILHVGGSTSTLDRLPSRLQQSKSQRSLSLRDELEELAYENSYLKAELAWNKETRQVLMHLHGRTLEAVSILSEALTETTSQLRRSSPARSPAPSRRPLKLFQYVGQVVHDFDIQTTSSGAHPRLNSVLWVTSAVAGFISLALAVSVLLDPEFAESGVSIFRFNFTSLLSTQFLSERQLELLSIPEASSEDVPPIVATAVEGAASDIQAAQTVVSSALQAAATDAATAVQSDLSTVVPENMSIGLGKVCFGWENNSTQDCRGLPFNISSVVPSTLSGILSAPLQQLQEVENKVVSAILETVRRSLIVGIVLLLMFFLLLLFWEFPNDLWRRAVMTPLGFTCLVVPFLISTAVMFVVQSDIRKKIDDSSLISVQDGGASNLILVGLIFSILMFGATVSITLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUF2</accession>
    <name>B8LUF2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">JmjC domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_071250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341112.1">
        <property type="nucleotide sequence ID" value="XM_002341071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUF2"/>
    <dbReference type="STRING" id="441959.B8LUF2"/>
    <dbReference type="GeneID" id="8107596"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_071250"/>
    <dbReference type="eggNOG" id="KOG2132">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054409_0_0_1"/>
    <dbReference type="InParanoid" id="B8LUF2"/>
    <dbReference type="OMA" id="WIGHPPT"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="PhylomeDB" id="B8LUF2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF105">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="146"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="340" mass="38885" checksum="3BF7D10F232EAA68" modified="2009-03-03" version="1">MRPIRIYRLSSKRVKHSRDTHSRISTHFRNFHHSTNLPSIKWIPPNTIPDENDINHFRQHYFQVEKPVVIRAAKFVREDLPGYKKWFTAGGKEDDNSHLQLNYKYLSRFGDAVVPLEMTTTTSSSNGEDNGEVQFQRINAPLSMFLEWMQLSAQHETPAAATKTQIYLAQAYISDLPNLLSQDFSPPPRLVTETGRNDIYAANLWIGASPTYTPLHRDPNPNLFVHLAGLKRARMLNPGDGRGVFVDVRSRVENEHRLESSGSSSIRGEEMMMGVERRLLEDIIWQQHSKESSTQSDGNGMVGYDVLLERGDALFIPKGWWHSLKGVGKGNTASVNWWFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUX7</accession>
    <name>B8LUX7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS polyamine transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_060890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002339985.1">
        <property type="nucleotide sequence ID" value="XM_002339944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUX7"/>
    <dbReference type="STRING" id="441959.B8LUX7"/>
    <dbReference type="GeneID" id="8107356"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_060890"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_3_1"/>
    <dbReference type="InParanoid" id="B8LUX7"/>
    <dbReference type="OMA" id="GDWRWTQ"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="PhylomeDB" id="B8LUX7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF182">
        <property type="entry name" value="POLYAMINE TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="50"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED22598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="481" mass="51874" checksum="C53399FB2E68BA79" modified="2009-03-03" version="1">MSGTDVVKEDANDISSGGNLIGLGSVNGVDKPSRKAINAMNWPLWMKIYHTAIPCFLAFLITFTSSVDVPATEALMKEFNISQTKSLLSGTLYMLGLAFGPMIMAPLSEFVGRWWLYLVTSSSIVAFACGAAASKSFATLLVCRFFCGFLGSAGVAIGAGTILDVWGGAKAGGLARLLFICGPFLGPSLGPLTGAYAMHEYDGDRRWTQWVVALIGAPTWILILFMKETSDSRIKPTREHSGPFGIVIIALSTLKAAAARSWSILTTESIAFSLTLYTGYAYAVIFSYFASATYVYEIDFGFNERQVGLSFISVVIGYFLAAVMHVVVEGTLYARAVRNAPDGYPAPEHRLYTAMAGSVFLPIGLFWYAWGAQPNGHWAVAVASGIPFGLGAFVLFLSSIIYLVEAYGAAAAASALAANGSIRYMLGAIFPLFTIQMYENLGIHWAGSVFAFLSLALLPIPWLLFKYGHLLRRNSRFISST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8LV94</accession>
    <name>B8LV94_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_065970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340531.1">
        <property type="nucleotide sequence ID" value="XM_002340490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LV94"/>
    <dbReference type="FunCoup" id="B8LV94">
        <property type="interactions" value="215"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LV94"/>
    <dbReference type="GeneID" id="8102412"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_065970"/>
    <dbReference type="eggNOG" id="ENOG502S9TF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_397498_0_0_1"/>
    <dbReference type="InParanoid" id="B8LV94"/>
    <dbReference type="OMA" id="IAISFRR"/>
    <dbReference type="OrthoDB" id="3365636at2759"/>
    <dbReference type="PhylomeDB" id="B8LV94"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF39">
        <property type="entry name" value="TRANSCRIPTION FACTOR PBCR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="625"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="638"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED23144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="693" mass="77702" checksum="40FA521679A4FD95" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVC3</accession>
    <name>B8LVC3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_066240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340560.1">
        <property type="nucleotide sequence ID" value="XM_002340519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVC3"/>
    <dbReference type="GeneID" id="8105127"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_066240"/>
    <dbReference type="eggNOG" id="ENOG502TAF1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1171287_0_0_1"/>
    <dbReference type="InParanoid" id="B8LVC3"/>
    <dbReference type="OrthoDB" id="4223073at2759"/>
    <dbReference type="PhylomeDB" id="B8LVC3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="237" mass="27225" checksum="F1D3E3C478497FFA" modified="2009-03-03" version="1">MELPQPQAEEAVSSNDRVGKKQRDREEEAGYIMDDLKSGKSVLLLQETPKAKTSHCQSWRCMPRKRTGKPVIKSHYRFMLKDISVPSKRKAEYYHVTCLERLLPDLSALVRDGHLKMDGWISAPVDSNVCLESSAEMVADWFKYGGRTFDLGCYANFRKDHREWDNDCSTRWINHHLGHGEQPDNACNYCQSLPDPEEPKKEDYFPDDPSVISLSQMLASMSGQANIDKCGRRRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8LW45</accession>
    <name>B8LW45_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxal reductase (AKR8), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_074510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341460.1">
        <property type="nucleotide sequence ID" value="XM_002341419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LW45"/>
    <dbReference type="FunCoup" id="B8LW45">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LW45"/>
    <dbReference type="GeneID" id="8104719"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_074510"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_1"/>
    <dbReference type="InParanoid" id="B8LW45"/>
    <dbReference type="OMA" id="YPVEETI"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="PhylomeDB" id="B8LW45"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19077">
        <property type="entry name" value="AKR_AKR8A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED24073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="321" mass="35183" checksum="F6A06112C70BF310" modified="2009-03-03" version="1">MPTLLGRQVGSTGYGLMRMTWNPSPPPKETCFETLNTALELGANFWNGGEIYGTSNYNSCHLLQAYFEKYPQNADKVVLSIKGGTVKGGLQPDGSEENIRRSVDDCLKVLKGTKSIDIFECARQDPKTTVEQTVTILAKLVKEGKIGGIGLSEVDAETIRRAHKVHPIAAVEVELSLWSLDILENDIAKTCAELNIPVIAYSPLGRGAFTGEITKLTDIPEGDFRRHVPKFHDGNYENNLKLIQEVASLAKRKSVAPAQIALAWVRSLSDKPGLPTIIPIPGGTTKDKVIQNMQGVETLTDEEMAEVDALLKKHEVKGTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8LW46</accession>
    <name>B8LW46_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C2H2 finger domain protein (Gli3), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_074520</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341461.1">
        <property type="nucleotide sequence ID" value="XM_002341420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LW46"/>
    <dbReference type="STRING" id="441959.B8LW46"/>
    <dbReference type="GeneID" id="8101958"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_074520"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046889_1_0_1"/>
    <dbReference type="InParanoid" id="B8LW46"/>
    <dbReference type="OMA" id="QEQVTVC"/>
    <dbReference type="OrthoDB" id="3214149at2759"/>
    <dbReference type="PhylomeDB" id="B8LW46"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000201">
        <property type="entry name" value="C2H2 finger domain protein (Gli3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000031">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="172"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED24074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="364" mass="40000" checksum="B3B1E0C0E0CB17AA" modified="2009-03-03" version="1">MADSPGSPLSSIASDELTEDTKLDKDGHSPSVSSMPPSKRRRTGVASWDHHTPISSVQGDILPTSPSSPISSDTDGEIPNSPSLLALIGGGQDDDYSGQGGDQVSICRWDGCEAGDLGNMDNLVNHIHDDHIGTRQKKYSCEWIDCSRKGQTHASGYALRAHMRSHTREKPFYCALPECDRSFTRSDALAKHMRTVHETEALRPSDPVPKSQLLNNQQNTATPINKVQRIKLKLNFGPREDTPSSTNGEGGTTGNVDGQEAELVPVPEFTPDLGFDAHELALPPSQLYRLLRRQVHWAEIETSKLKQQWQELEPKRKEAFFEKEAALTEVIDAEGRLSKIVYDAQREADKESGNAQNGAEEVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8LX85</accession>
    <name>B8LX85_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_062230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340122.1">
        <property type="nucleotide sequence ID" value="XM_002340081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LX85"/>
    <dbReference type="GeneID" id="8099929"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_062230"/>
    <dbReference type="eggNOG" id="ENOG502R8CV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017138_1_1_1"/>
    <dbReference type="InParanoid" id="B8LX85"/>
    <dbReference type="OMA" id="APMGCHF"/>
    <dbReference type="OrthoDB" id="4226874at2759"/>
    <dbReference type="PhylomeDB" id="B8LX85"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="2"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="597" mass="68252" checksum="BD62B0A14315AC71" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXZ2</accession>
    <name>B8LXZ2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_062940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340194.1">
        <property type="nucleotide sequence ID" value="XM_002340153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXZ2"/>
    <dbReference type="STRING" id="441959.B8LXZ2"/>
    <dbReference type="GeneID" id="8100185"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_062940"/>
    <dbReference type="eggNOG" id="ENOG502SHWQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038384_1_0_1"/>
    <dbReference type="InParanoid" id="B8LXZ2"/>
    <dbReference type="OMA" id="LYFGMWY"/>
    <dbReference type="OrthoDB" id="4838853at2759"/>
    <dbReference type="PhylomeDB" id="B8LXZ2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42024">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42024:SF1">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED22807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="402" mass="45067" checksum="EBA95BAE5920C34B" modified="2009-03-03" version="1">MADAVETTTDGPPPLPYSLRQRKRSIAFFWTLFIIDTLIQPLVLYYALRYGTSLSLNLVFSISTAALGGVSVFEYFFRLYNLMRSKSRARPLNARKSWLDFFQINFTIVWLILAVELIVGTVPTIPYIRLLAMPLPTVMFYFGGVHLTLDILRMSGHKAPFRISSTPQGSVMPTALYVLVEDIVAVDGGGGQSYRYALRRRYLSSPYFRRMLFEMNCFWAGGSLVAAAAITAIIFTTPINVAYTLGWSLPFAWAGLWTLITFPWVQAELRHEKETWHLVQQHDGGEPFTDDITANPRTRMNSFQARILPFTAREKQLSPERESSIAEEPGSAQDNENIPADHTTRAPAGDDENFVGTVTAEEGTIGAGGLERSASRHDHEIATNNDNKSDNTPDPSRDLEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8LY96</accession>
    <name>B8LY96_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Voltage-gated hydrogen channel 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Hydrogen voltage-gated channel 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSTA_067730</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340728.1">
        <property type="nucleotide sequence ID" value="XM_002340687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LY96"/>
    <dbReference type="STRING" id="441959.B8LY96"/>
    <dbReference type="GeneID" id="8102379"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_067730"/>
    <dbReference type="eggNOG" id="ENOG502QQMU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_931200_0_0_1"/>
    <dbReference type="InParanoid" id="B8LY96"/>
    <dbReference type="OMA" id="KFHTFDA"/>
    <dbReference type="OrthoDB" id="427456at2759"/>
    <dbReference type="PhylomeDB" id="B8LY96"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030171">
        <property type="term" value="F:voltage-gated proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031846">
        <property type="entry name" value="Hvcn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480">
        <property type="entry name" value="F20B24.22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480:SF1">
        <property type="entry name" value="VOLTAGE-GATED HYDROGEN CHANNEL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="207"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="15">
        <location>
            <begin position="144"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EED23341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="299" mass="34339" checksum="F470950A1CB04031" modified="2009-03-03" version="1">MSELVSPLLGDHNTDLENQPQTGNKDKHHHRSKTFPLPTSVEFSRDVSGSRFIGNLASWSKKGVEGLGISRNSSYNRQYHEHQQSNEEQQYYDDDEYPYDVHPNTSYYAHLRAKTRAFLSSKWGHYIVLCMVAVDVACIFADFLIELWVCELSERHQTPIDRRWSLAQEALGLVGLIFSCLFMLELIASVLSFGLGYFRSKFHTFDALVIVLAFILDIALRGVVEELGSLIVVLRLWRVFKIIEEMSEVSAEMMERYEVELDNLRVENSKLRRKLKGYGYNDEGDDIEGNIGGDEEVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYC5</accession>
    <name>B8LYC5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7605 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_063350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340241.1">
        <property type="nucleotide sequence ID" value="XM_002340200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYC5"/>
    <dbReference type="STRING" id="441959.B8LYC5"/>
    <dbReference type="GeneID" id="8102386"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_063350"/>
    <dbReference type="HOGENOM" id="CLU_1230627_0_0_1"/>
    <dbReference type="InParanoid" id="B8LYC5"/>
    <dbReference type="OrthoDB" id="3598281at2759"/>
    <dbReference type="PhylomeDB" id="B8LYC5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056024">
        <property type="entry name" value="DUF7605"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24564">
        <property type="entry name" value="DUF7605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7605" evidence="1">
        <location>
            <begin position="13"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="225" mass="26491" checksum="6E06D6E8FC3F4243" modified="2009-03-03" version="1">MYNGNPPGRGPHAVNWNRDLIWKMRTDLKYQWKLFEEEIPTIFEKLMQRLKNNLDKLELHLGGLDPKSVEGTRVHTQDFEHMYSRIQREFENGVRSIHGRASESDSQSYVVQEMIPTYDAASEISGPEKATQQRTIIQGKIKDGTLFDGILRHLISDMEEQFETFHKVKDFLYETVDSVRENFDMIMSDAEEKQKAEERLKKQLADEVQQLLGKYQEIRFSMLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYR5</accession>
    <name>B8LYR5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_068480</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340810.1">
        <property type="nucleotide sequence ID" value="XM_002340769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYR5"/>
    <dbReference type="STRING" id="441959.B8LYR5"/>
    <dbReference type="GeneID" id="8110194"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_068480"/>
    <dbReference type="eggNOG" id="KOG1745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078295_4_0_1"/>
    <dbReference type="InParanoid" id="B8LYR5"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="PhylomeDB" id="B8LYR5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000085">
        <property type="entry name" value="Histone H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="88"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED23423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="187" mass="21387" checksum="C225B6FE772D5C40" modified="2009-03-03" version="1">MDEEVRDKLGDGGGGDLNLGVVRLAISSFNHYKKSPHFTIARTKIIARKISKGGKAKTVLPARKSLPKGKTVTQHPPAPKKYHLKWATNALQEIRRYQKSIELVIPKLPFQRLVREITQNITTNQIRFQALAIQALQEACEAFLVKEFEMTNLVAIHAHRVTIQPRDMRLVERLRKIMNRSSFQDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZH5</accession>
    <name>B8LZH5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Checkpoint protein kinase (SldA), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_093030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479020.1">
        <property type="nucleotide sequence ID" value="XM_002478975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZH5"/>
    <dbReference type="FunCoup" id="B8LZH5">
        <property type="interactions" value="499"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LZH5"/>
    <dbReference type="GeneID" id="8102547"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_093030"/>
    <dbReference type="eggNOG" id="KOG1166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002115_1_0_1"/>
    <dbReference type="InParanoid" id="B8LZH5"/>
    <dbReference type="OMA" id="NCEKGVG"/>
    <dbReference type="OrthoDB" id="248495at2759"/>
    <dbReference type="PhylomeDB" id="B8LZH5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13981">
        <property type="entry name" value="STKc_Bub1_BubR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.430:FF:000003">
        <property type="entry name" value="Checkpoint serine/threonine-protein kinase BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012572">
        <property type="entry name" value="Mad3/Bub1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF4">
        <property type="entry name" value="BUB1 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08171">
        <property type="entry name" value="Mad3_BUB1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0137">Centromere</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="7">
        <location>
            <begin position="64"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="815"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="237"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="521"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="544"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="559"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED22057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1228" mass="138416" checksum="09787D451FF17BA6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZJ5</accession>
    <name>B8LZJ5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ADP-ribosylation factor family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_093230</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002478995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZJ5"/>
    <dbReference type="STRING" id="441959.B8LZJ5"/>
    <dbReference type="GeneID" id="8102567"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_093230"/>
    <dbReference type="eggNOG" id="KOG0075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_10_3_1"/>
    <dbReference type="InParanoid" id="B8LZJ5"/>
    <dbReference type="OMA" id="FRNMWER"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="PhylomeDB" id="B8LZJ5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098852">
        <property type="term" value="C:lytic vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04159">
        <property type="entry name" value="Arl10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001015">
        <property type="entry name" value="ADP-ribosylation factor-like protein 8B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044154">
        <property type="entry name" value="Arl8a/8b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
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        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
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        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732:SF7">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="133"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED22077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="186" mass="20926" checksum="DFE3F64D556196D8" modified="2009-03-03" version="1">MAGIFRIIYDWLLRMFWATEMDVTMIGLQNAGKSSLLRVLAVCVFSFLSVPSIPTIGFNTKKVQKGHVTLKCWDLGGQPRFRPMWERYCRGVNAIVYIVDAADHAALPVATEELHDLLDKPSLDGIPLLVLGNKSDLPNKLSVDELIEEMDLKSIVRREVSCYGISAKEETNLDAVLHWLIARANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZQ9</accession>
    <name>B8LZQ9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_080740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477804.1">
        <property type="nucleotide sequence ID" value="XM_002477759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZQ9"/>
    <dbReference type="STRING" id="441959.B8LZQ9"/>
    <dbReference type="GeneID" id="8101379"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_080740"/>
    <dbReference type="HOGENOM" id="CLU_000680_26_1_1"/>
    <dbReference type="InParanoid" id="B8LZQ9"/>
    <dbReference type="OMA" id="SSDIIMF"/>
    <dbReference type="OrthoDB" id="5077812at2759"/>
    <dbReference type="PhylomeDB" id="B8LZQ9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED20841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19055" checksum="482A55982D9F212B" modified="2009-03-03" version="1">MADKSADLPAINPLQYAPWYPRKPRGNAQARIGAPMGRTKEQAAANFMAFQRTIPSSDIIMFSDGSRLADGRAGGGYIGLQAHHQFLRSSLSYGHGKEVFNAEVEAALASAQAAIVYPTAQFTTNLWICFDNLEVAIRLLSPSTGSSQEIFESFRTLAAAWPLRKRLPHTKSGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZT6</accession>
    <name>B8LZT6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Subgroup IIIi aminotransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_081010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477831.1">
        <property type="nucleotide sequence ID" value="XM_002477786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZT6"/>
    <dbReference type="STRING" id="441959.B8LZT6"/>
    <dbReference type="GeneID" id="8101406"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_081010"/>
    <dbReference type="eggNOG" id="KOG0975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031922_1_0_1"/>
    <dbReference type="InParanoid" id="B8LZT6"/>
    <dbReference type="OMA" id="CHEVKQV"/>
    <dbReference type="OrthoDB" id="409992at2759"/>
    <dbReference type="PhylomeDB" id="B8LZT6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009081">
        <property type="term" value="P:branched-chain amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000010">
        <property type="entry name" value="Branched-chain amino acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825">
        <property type="entry name" value="AMINO ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825:SF2">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 3, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED20868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="380" mass="41727" checksum="7BB63FB37D8012D3" modified="2009-03-03" version="1">MTFAPPAANLDPSIDWAKLGLAVTDIVNGHVECRYDAEAGKWLAPTFVRDPYLRIHGLAPGLNYGQQVYEGLKASRNRDEEILLFRADRHARRMAHSAYYVSIPPIPEELFLDSVRLAVAENAEFVPPYATNAALYIRPLAFGSAGHFALTPPREYLFCVFVQPFVTYHGSGAADALIIDEFDRAAPRGTGSAKVGGNYAPVMRYTDKARAEGFPLTLHLDSKTQTEIDEFSTSSFIGVKSGNDTVSPTLVVPDSKNAIESVTSDSTVAVAKAWGWTVEKRPVLYNQLADFTEVIAAGTAAALVPIRSITRRSTGDKFTFESGPLCQKLSTYLRQIQRGESSDFPEWVEVLQPPEVVYNKYKTAELPTYGNGHENGLAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZY7</accession>
    <name>B8LZY7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_081520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477882.1">
        <property type="nucleotide sequence ID" value="XM_002477837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZY7"/>
    <dbReference type="GeneID" id="8104790"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_081520"/>
    <dbReference type="eggNOG" id="ENOG502QR4T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_4_0_1"/>
    <dbReference type="InParanoid" id="B8LZY7"/>
    <dbReference type="OrthoDB" id="4207519at2759"/>
    <dbReference type="PhylomeDB" id="B8LZY7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="3">
        <location>
            <begin position="13"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="194"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="252"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED20919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="58503" checksum="FCE4EA9B05BBF23F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZZ4</accession>
    <name>B8LZZ4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin 2,3/unc44, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_081590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477889.1">
        <property type="nucleotide sequence ID" value="XM_002477844.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LZZ4"/>
    <dbReference type="GeneID" id="8104797"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_081590"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_19_1"/>
    <dbReference type="InParanoid" id="B8LZZ4"/>
    <dbReference type="OMA" id="IHVAARW"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="PhylomeDB" id="B8LZZ4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="3">
        <location>
            <begin position="46"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="347"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="853"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="919"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1196"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1229"/>
            <end position="1251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED20926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1452" mass="164399" checksum="EC2F54350AE48886" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8M056</accession>
    <name>B8M056_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pantothenate transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_083850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478116.1">
        <property type="nucleotide sequence ID" value="XM_002478071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M056"/>
    <dbReference type="GeneID" id="8101478"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_083850"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_3_1"/>
    <dbReference type="InParanoid" id="B8M056"/>
    <dbReference type="OMA" id="ATIMFIW"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="PhylomeDB" id="B8M056"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF54">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002874649" evidence="7">
        <location>
            <begin position="18"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED21153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="316" mass="34855" checksum="0AD91800711CD812" modified="2009-03-03" version="1">MAALRLLLSLFEAGVFPGCSFVLTSWYEPGELYRRMAIFYSGASAALDGTWGYRGWRFIYVIEGVFTFLCALTGFYFIYDTPAKVKWLSDEEQEFLLLRAKFSAGGESGVTEETRFSWKPASAAMKSSHIYATALIEFTCCVGVYGYSFVLPTIINNLGYTAANAQAMSVPPYVFACICLNVMALVGLVIIMVSVRYTNLVGVTLFGVFITTAGLYPISPAAAAWVSLNCAGSMKRAIVGSNIYIGDQAPRYPVGFGVSIGMLAMFGCIWPITYYFILKRTNAKRDAISLEEIRAKYTEEQLADMSDLSPTFRYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0K8</accession>
    <name>B8M0K8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HHE domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_085360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478268.1">
        <property type="nucleotide sequence ID" value="XM_002478223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0K8"/>
    <dbReference type="STRING" id="441959.B8M0K8"/>
    <dbReference type="GeneID" id="8106142"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_085360"/>
    <dbReference type="eggNOG" id="ENOG502S054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079417_0_0_1"/>
    <dbReference type="InParanoid" id="B8M0K8"/>
    <dbReference type="OMA" id="IEDMFDQ"/>
    <dbReference type="OrthoDB" id="9983919at2759"/>
    <dbReference type="PhylomeDB" id="B8M0K8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585:SF1">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="189" mass="21977" checksum="3265264BF10AF139" modified="2009-03-03" version="1">MTLISQAIKNDHRELEDAYSKILSAATDDEKRRWQNQFTWELARHSIGEELLVYPAFEKNLADGKQLADKDRAEHQKVKELLYKFQGLQPKDHEFTPTLRYLWSDLSQHIREEEKHDLVQLENALQQADSEKLTTKFNRTKKFIPTRSHPDAPDKPPFETVAGLMAAPLDHLSDLFRKFPGESKSELPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1U9</accession>
    <name>B8M1U9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc-dependent alcohol dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_085580</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478290.1">
        <property type="nucleotide sequence ID" value="XM_002478245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1U9"/>
    <dbReference type="STRING" id="441959.B8M1U9"/>
    <dbReference type="GeneID" id="8104523"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_085580"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_5_1"/>
    <dbReference type="InParanoid" id="B8M1U9"/>
    <dbReference type="OMA" id="INHPARW"/>
    <dbReference type="OrthoDB" id="5363962at2759"/>
    <dbReference type="PhylomeDB" id="B8M1U9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF25">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="10">
        <location>
            <begin position="31"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="9">
        <location>
            <begin position="201"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED21327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="402" mass="43241" checksum="1895D52473555CF0" modified="2009-03-03" version="1">MTTTTKSKALILHGAKDLRLETRDTPVPTGNEVQLAIRATGLCGSDLHYYIHGRNGDFVVQRPMALGHESSGLVTATGPDVKTLRVGDRVALEVGLPCRKCLYCASDRYNLCANMRFRSSAKTFPHLDGTLMQFTNHPEDMCHKLPDSVSYAGGALAEPLAVCLHAIRRSHPPTKEEAELARSLGEESAAMVFGAGAIGLLMAAALATSQHFSSIIIADIDARRLKVAESLGLGLKTHLIERSATTPPAKDAPQEEQTAYAMKTARETADKIKKTHNIPNGFARVYECTGVPPCIQAGIYAAAAGGVLVQVGMGAPILTLHHGAAMLREVDIIGVFRYDKYAYPAAIELLEKEAFKRVEDKIVTHRVDLSVEGQGERAFTLAAKGVDEEGVAVVKVLIESSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1V2</accession>
    <name>B8M1V2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-deoxy-D-gluconate 3-dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_085610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478293.1">
        <property type="nucleotide sequence ID" value="XM_002478248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1V2"/>
    <dbReference type="STRING" id="441959.B8M1V2"/>
    <dbReference type="GeneID" id="8104526"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_085610"/>
    <dbReference type="eggNOG" id="KOG1200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="InParanoid" id="B8M1V2"/>
    <dbReference type="OMA" id="LFGVQCD"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="PhylomeDB" id="B8M1V2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000398">
        <property type="entry name" value="Probable 2-deoxy-D-gluconate 3-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF5">
        <property type="entry name" value="2-DEHYDRO-3-DEOXY-D-GLUCONATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="10"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED21330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="260" mass="27524" checksum="40301687CCAD1263" modified="2009-03-03" version="1">MASLFSIEGRTALVTGGTRGIGQAMAIALAEAGADIVLVQRHESNTATRDEITKLGRKAVIHVAELSDREAVKKIIPTLVQQGVQPDILLNCAGIQKRHPSEKFPDEDWDEVINVNLTSVFTLAREFGANLLSRGASEFPSGRRGSVINVASLLSFQGGITVPAYAASKGGVAQLTKALSNEWVAKGINVNAIAPGYIDTDMNVALINDANRNAGIMARIPAGRWGKPEDFKGVVVFLASPASSYVSGEIITVDGGWMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8M247</accession>
    <name>B8M247_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_087470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478474.1">
        <property type="nucleotide sequence ID" value="XM_002478429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M247"/>
    <dbReference type="STRING" id="441959.B8M247"/>
    <dbReference type="GeneID" id="8100876"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_087470"/>
    <dbReference type="HOGENOM" id="CLU_1416039_0_0_1"/>
    <dbReference type="InParanoid" id="B8M247"/>
    <dbReference type="OrthoDB" id="5068804at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="1">
        <location>
            <begin position="9"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="192" mass="21289" checksum="4FF4CCD5F3CDBCB3" modified="2009-03-03" version="1">MRNSTNNSRFKNKQIVAFQSRLASYKLTLVISLDFLTLKNTTKDLETTRALENKIENATSRFAGQMQGLQIGLQTFLEANATPTQNEPQLTDTQIELAKEQESRILQAIEQQNIVLGYCYRACMAALRGTTQVTGNTYKYVSASDEVKMLVGDVGNVSGSAKHVYEDITAGGKSHVVVGNMQGEYMKDFFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2I3</accession>
    <name>B8M2I3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor hoxa13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_091350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478857.1">
        <property type="nucleotide sequence ID" value="XM_002478812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2I3"/>
    <dbReference type="STRING" id="441959.B8M2I3"/>
    <dbReference type="GeneID" id="8098521"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_091350"/>
    <dbReference type="eggNOG" id="ENOG502SGAD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005461_1_0_1"/>
    <dbReference type="InParanoid" id="B8M2I3"/>
    <dbReference type="OMA" id="GVAHARY"/>
    <dbReference type="OrthoDB" id="3260408at2759"/>
    <dbReference type="PhylomeDB" id="B8M2I3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23242">
        <property type="entry name" value="TRANSCRIPTION FACTOR HOXA13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23242:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR HOXA13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="587"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1267" mass="136392" checksum="4D24FDCB0775E6CF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2I9</accession>
    <name>B8M2I9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_091410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478863.1">
        <property type="nucleotide sequence ID" value="XM_002478818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2I9"/>
    <dbReference type="STRING" id="441959.B8M2I9"/>
    <dbReference type="GeneID" id="8098527"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_091410"/>
    <dbReference type="eggNOG" id="ENOG502QVJ3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1264299_0_0_1"/>
    <dbReference type="InParanoid" id="B8M2I9"/>
    <dbReference type="OrthoDB" id="4359445at2759"/>
    <dbReference type="PhylomeDB" id="B8M2I9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="1">
        <location>
            <begin position="142"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="219" mass="25385" checksum="2FFD6D5FEADD3A78" modified="2009-03-03" version="1" fragment="single">FTKTYGYVLVTKRSKTLKEGGSIRRVYLQCSRREVYCERTNEETYVCWRLDRTDPRHDYYSAARSTLASLRHEGIESKETQIKSYLDSYMSINQILSTLYKDNLKLIAKPRDIYNKKKKSRDDFLNSKTPVQALISVVLDDGFGFISDEKEGSYKFILECLVKVYAQADLPLPNCILTNKDMALMNAIPTVFPMANNTICLWHIEKNILTRARPILTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2R7</accession>
    <name>B8M2R7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bicyclomycin resistance protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_094180</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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            <end position="144"/>
        </location>
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        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
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        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
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        <location>
            <begin position="587"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1099"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1115"/>
            <end position="1127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED21982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1204" mass="131867" checksum="84441E3C0D9EA196" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8M366</accession>
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        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase, putative</fullName>
        </submittedName>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
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    <dbReference type="STRING" id="441959.B8M366"/>
    <dbReference type="GeneID" id="8099466"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_092880"/>
    <dbReference type="eggNOG" id="ENOG502R6JX">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_421606_0_0_1"/>
    <dbReference type="InParanoid" id="B8M366"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF2">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED22042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="650" mass="72646" checksum="FEA066AD1C11914E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3S7</accession>
    <name>B8M3S7_TALSN</name>
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        <recommendedName>
            <fullName evidence="8 9">Ribosomal RNA-processing protein 8</fullName>
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    </protein>
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        <name evidence="11" type="ORF">TSTA_038750</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
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    </reference>
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        <subcellularLocation>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
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        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Methyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="3 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
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            <end position="187"/>
        </location>
    </feature>
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        <location>
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            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
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            <end position="524"/>
        </location>
    </feature>
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        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
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            <end position="158"/>
        </location>
    </feature>
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        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
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            <begin position="422"/>
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    </feature>
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        <location>
            <begin position="515"/>
            <end position="524"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006301"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00076672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED20670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="545" mass="60373" checksum="140F6BE5184AECC0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8M442</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">TSTA_039790</name>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M442"/>
    <dbReference type="STRING" id="441959.B8M442"/>
    <dbReference type="GeneID" id="8109317"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_039790"/>
    <dbReference type="eggNOG" id="ENOG502SM4W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121100_1_0_1"/>
    <dbReference type="InParanoid" id="B8M442"/>
    <dbReference type="OrthoDB" id="3001700at2759"/>
    <dbReference type="PhylomeDB" id="B8M442"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="184" mass="20330" checksum="5DAEB8A2B91429AB" modified="2009-03-03" version="1">MDTINKTTKSASEHTEEQKQHFYNNLPVNERENKSYTEWVREAYQEQYEKWMPWIEDQYLKWFGKGDNKASYATKDTLNKSKVTGVSQIDQLQDDVHNVVGNQLGENGIAAPIGNLASKEGINRAQRNGKNEKGSYGSPVAGYTDSMISGTKNSAQYIGNSISGSAKNAASYMGLGSGSSQSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8M450</accession>
    <name>B8M450_TALSN</name>
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        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">TSTA_039870</name>
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    <organism evidence="1 2">
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        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481227.1">
        <property type="nucleotide sequence ID" value="XM_002481182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M450"/>
    <dbReference type="STRING" id="441959.B8M450"/>
    <dbReference type="GeneID" id="8109325"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_039870"/>
    <dbReference type="eggNOG" id="ENOG502RUBM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_26_3_1"/>
    <dbReference type="InParanoid" id="B8M450"/>
    <dbReference type="OMA" id="RIATDIW"/>
    <dbReference type="OrthoDB" id="4357294at2759"/>
    <dbReference type="PhylomeDB" id="B8M450"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED20793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="48289" checksum="F720676A2E118ABB" modified="2009-03-03" version="1">MTASLLTLDVKGAFDAVLPGRLIRRLRSPVSGILFMLYIAPLFRLGNPRNKFGYADDAANLAISTSLATNCEALSDSLQEALNWGAAEGITFTPDKYELLHFSQRKADQDPTCTPSVKAGSITVSENTKRLYLRWLGILYDKKLTFKWHVSETVSKALTVANALRSLGNTARGVKPYLLQQAVLACVLHKAYYGARVVLLVFRITPISVLYRESGFSPLEIELDRIALLATVRLRRLDPYHPLRRRAEQVASNSRQTSRFARRILALPNSKQINPLQHAPWHPRETRENAQARIGAPMGRSKEQAAADFIAFQRTIPSSDIIIFSDGSRLVDGRAGGGYIGFQAHNQFLRSSLSYKHGKEVFDAEAEAALAGAQAAIAYPTAQFATNLWICLDNLEVATRLLSPSTGSSQEAFESFRTLAAGWPLYERLPHTKSGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4F6</accession>
    <name>B8M4F6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SH3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_024730</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3RF family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479585.1">
        <property type="nucleotide sequence ID" value="XM_002479540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4F6"/>
    <dbReference type="STRING" id="441959.B8M4F6"/>
    <dbReference type="GeneID" id="8106690"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_024730"/>
    <dbReference type="eggNOG" id="KOG2177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005224_1_0_1"/>
    <dbReference type="InParanoid" id="B8M4F6"/>
    <dbReference type="OMA" id="NNCVNQG"/>
    <dbReference type="OrthoDB" id="1305878at2759"/>
    <dbReference type="PhylomeDB" id="B8M4F6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052256">
        <property type="entry name" value="E3_ubiquitin-ligase_CHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079">
        <property type="entry name" value="UBIQUITIN LIGASE PROTEIN CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="25"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="849"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="102"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="252"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="559"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="770"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="352"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="398"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="564"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="800"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="817"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED19151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="912" mass="100301" checksum="6F553B4C4B107E2F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4H9</accession>
    <name>B8M4H9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Impact N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_024960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479608.1">
        <property type="nucleotide sequence ID" value="XM_002479563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4H9"/>
    <dbReference type="STRING" id="441959.B8M4H9"/>
    <dbReference type="GeneID" id="8106713"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_024960"/>
    <dbReference type="eggNOG" id="ENOG502SK8I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031573_1_0_1"/>
    <dbReference type="InParanoid" id="B8M4H9"/>
    <dbReference type="OMA" id="ELDKRAW"/>
    <dbReference type="OrthoDB" id="514070at2759"/>
    <dbReference type="PhylomeDB" id="B8M4H9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="41578" checksum="86098E7043F07293" modified="2009-03-03" version="1">MAAQLQALLRFLSQDAKVPLASAMGKIKDLQAAGLQNVDDISTSNLETLQSIFKDGKIAKQVHNAAKRVAKEGVQKRGASDDGQATTDKSSSTTKKMKFSNESGGNRTPYEIEYSLTLPITSEPEEVLSKTILKTNRAPLVLAFAVAVTKYTMPEQPLSSRLSLAQTVVSANSRSKAISLGIESSAAAVDEEGKGQPTVRVLGREISVLKRWDYDPDEGRPEGDDAVDEILSNSTTNTGLPPLWGLDLEALRKRDSVSAKGNPGYRSTSNLPIHTPEVARSYLLKSFTMMKEIDDNTEKADTSKKKKPRESTAEKERCLGLLLQVLDILFSSWASTLSAEELDRRAWTWYVRVRPEVQAGVAGWGEKGRLNLADILSLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4U2</accession>
    <name>B8M4U2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="23">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">TSTA_026830</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 23">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38583"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:38584"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66036"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:66037"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="23">Membrane</location>
            <topology evidence="23">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="23"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479811.1">
        <property type="nucleotide sequence ID" value="XM_002479766.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B8M4U2">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M4U2"/>
    <dbReference type="GeneID" id="8098963"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_026830"/>
    <dbReference type="eggNOG" id="KOG0206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000846_0_0_1"/>
    <dbReference type="InParanoid" id="B8M4U2"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="PhylomeDB" id="B8M4U2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070867">
        <property type="term" value="C:mating projection tip membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990531">
        <property type="term" value="C:phospholipid-translocating ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140351">
        <property type="term" value="F:glycosylceramide flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090554">
        <property type="term" value="F:phosphatidylcholine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140346">
        <property type="term" value="F:phosphatidylserine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090556">
        <property type="term" value="F:phosphatidylserine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099040">
        <property type="term" value="P:ceramide translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000048">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000108">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF180">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 21 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="27" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10 22 23" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 21 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 23" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="556"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1131"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1159"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1210"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1251"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1276"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1316"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="25">
        <location>
            <begin position="108"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="26">
        <location>
            <begin position="1096"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1366"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1468"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="1378"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1401"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1420"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1473"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1491"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="20">
        <location>
            <position position="625"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="625"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="625"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="626"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="627"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="627"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="760"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="801"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="824"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="859"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="939"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="940"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="941"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1044"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1050"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <position position="1070"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1073"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1074"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="1074"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050913"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00051303"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00052223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="EED19377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1513" mass="169446" checksum="6DA7F943C1BA7861" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6D2</accession>
    <name>B8M6D2_TALSN</name>
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        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 1</fullName>
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        <name evidence="9" type="ORF">TSTA_026180</name>
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    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
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    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        <text evidence="2">Belongs to the COG1 family.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        </location>
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        </location>
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    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="Proteomes" id="UP000001745"/>
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    <sequence length="779" mass="88057" checksum="0977C3732B4426F1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8M879</accession>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
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            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="8101889"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_036180"/>
    <dbReference type="HOGENOM" id="CLU_855747_0_0_1"/>
    <dbReference type="InParanoid" id="B8M879"/>
    <dbReference type="OrthoDB" id="4226811at2759"/>
    <dbReference type="PhylomeDB" id="B8M879"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED20392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="325" mass="36407" checksum="E38E71CCBCC820C2" modified="2009-03-03" version="1">MGPKRGKKGTPWPEPRFADDPDIRAYAAAAIKDLEALRKHQELLEIGMPREISTAVVDAFLHLARRLAQRLARVELNVEKTQKEVSQASREITTTKSNTNRLVEAICRPTLPTTTRGSVAKNSLSVGTQNELNQFGNRTRFAYQEISRIGITFRRDIEHYKSTLQPISRNHVTASSESYVQAWGRNVPSNPPTVPSVGLSSGGSSPLTPYPNQEDLEVYLEHTDSNIVNPIRRFPDQVVEKANLAIRSTQDTTIAHRRIVAARILPSGDITLLLGTVDDVDQLTRKNDWIKAFGTETRIRKRTWGVVLRGVDTNINPKQPQFKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8M898</accession>
    <name>B8M898_TALSN</name>
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        <submittedName>
            <fullName evidence="2">Histone h1.3., putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">TSTA_036370</name>
    </gene>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Talaromyces</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED20411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="441959.B8M898"/>
    <dbReference type="GeneID" id="8101908"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_036370"/>
    <dbReference type="eggNOG" id="ENOG502SW29">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1555773_0_0_1"/>
    <dbReference type="InParanoid" id="B8M898"/>
    <dbReference type="OrthoDB" id="5403747at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="185" mass="19756" checksum="6A063F866C5ECDFA" modified="2009-03-03" version="1">MSANDKNEVTINLSQSELKLIALGTRFSENGKVDYEKLAKYGGYTKGSAQVLYRKALRKLTDVYPIDADAMAGNGDAGSDPVTPTSKAKTPKTPNSRTSGKKRKDAAAAEDQDTTAAPQTPLGPTIDDAAGDALDAEMATSTKKPRKTSSKQATTNTFTPVNDPVNDDRFMKAEDAFDAFIKAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8B8</accession>
    <name>B8M8B8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Deoxyribodipyrimidine photo-lyase Phr1, putative</fullName>
            <ecNumber evidence="10">4.1.99.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_036560</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="6">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.3" evidence="10"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480865.1">
        <property type="nucleotide sequence ID" value="XM_002480820.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="B8M8B8">
        <property type="interactions" value="336"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M8B8"/>
    <dbReference type="GeneID" id="8101927"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_036560"/>
    <dbReference type="eggNOG" id="KOG0133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8M8B8"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="PhylomeDB" id="B8M8B8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0071949">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:circadian regulation of gene expression"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Deoxyribodipyrimidine photo-lyase"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
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        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
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        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
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        <property type="entry name" value="DNA_photolyase_1_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF18">
        <property type="entry name" value="SI:CH1073-390K14.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA_PHOTOLYASES_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA_PHOTOLYASES_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="9">
        <location>
            <begin position="275"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="123"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="167"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="516"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="528"/>
            <end position="532"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="567"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="570"/>
            <end position="577"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="668"/>
            <end position="670"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="602"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="655"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED20431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="771" mass="88571" checksum="E0B1A46EA7B13713" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8X7</accession>
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        <submittedName>
            <fullName evidence="4">PHD finger and SET domain protein, putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">TSTA_038460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
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    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED20640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="KOG1844">
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    <dbReference type="HOGENOM" id="CLU_009510_0_0_1"/>
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    <dbReference type="PhylomeDB" id="B8M8X7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SET_dom_sf"/>
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        <property type="entry name" value="UPSET, ISOFORM A"/>
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        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="276"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="187"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="511"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="526"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="635"/>
            <end position="682"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="732"/>
            <end position="880"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="2">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="526"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="670"/>
            <end position="680"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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        <location>
            <begin position="743"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="791"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED20640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="880" mass="96295" checksum="8A01CF533764E7B6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8M934</accession>
    <name>B8M934_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_111650</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481321.1">
        <property type="nucleotide sequence ID" value="XM_002481276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M934"/>
    <dbReference type="STRING" id="441959.B8M934"/>
    <dbReference type="GeneID" id="8098820"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_111650"/>
    <dbReference type="HOGENOM" id="CLU_044368_0_0_1"/>
    <dbReference type="InParanoid" id="B8M934"/>
    <dbReference type="OMA" id="AKTKCCY"/>
    <dbReference type="OrthoDB" id="4216928at2759"/>
    <dbReference type="PhylomeDB" id="B8M934"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="59"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED17329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="528" mass="58851" checksum="9CB06E759783EAD6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9A7</accession>
    <name>B8M9A7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">transketolase</fullName>
            <ecNumber evidence="3">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_114740</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="11">Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="3"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481659.1">
        <property type="nucleotide sequence ID" value="XM_002481614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9A7"/>
    <dbReference type="STRING" id="441959.B8M9A7"/>
    <dbReference type="GeneID" id="8101284"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_114740"/>
    <dbReference type="eggNOG" id="KOG0523">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_0_0_1"/>
    <dbReference type="InParanoid" id="B8M9A7"/>
    <dbReference type="OMA" id="FINIHTV"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="PhylomeDB" id="B8M9A7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000012">
        <property type="entry name" value="Transketolase, variant 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049557">
        <property type="entry name" value="Transketolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF6">
        <property type="entry name" value="TRANSKETOLASE-LIKE PYRIMIDINE-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="14">
        <location>
            <begin position="380"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="447"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="140"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="507"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="558"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="13">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="13">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED17667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="720" mass="79369" checksum="23CAC288B1AC09F6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAP5</accession>
    <name>B8MAP5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-ubiquinone oxidoreductase 39 kDa subunit, putative</fullName>
            <ecNumber evidence="2">1.6.99.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_112970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.6.99.3" evidence="2"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481461.1">
        <property type="nucleotide sequence ID" value="XM_002481416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAP5"/>
    <dbReference type="STRING" id="441959.B8MAP5"/>
    <dbReference type="GeneID" id="8105762"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_112970"/>
    <dbReference type="eggNOG" id="KOG2865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_4_1"/>
    <dbReference type="InParanoid" id="B8MAP5"/>
    <dbReference type="OMA" id="PEDQFTN"/>
    <dbReference type="OrthoDB" id="275457at2759"/>
    <dbReference type="PhylomeDB" id="B8MAP5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05271">
        <property type="entry name" value="NDUFA9_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000358">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 39 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="59"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="382" mass="43859" checksum="E4BAB7A77D971F27" modified="2009-03-03" version="1">MQKCRAFNGALGRKALVPTPAVQFQVQRRNIQDVHITRTGKPILKVQGGRSSLGGHTATVFGATGFLGRYIVNRLARAGCTVVVPFREEMTKRHLKVSGDLGRVVFMEYDLRNTQSIEESVRHSDVVFNLVGRQYPTKNFTYEDVHVDGAERIAEAVAKYDVDRFIHVSSYNAAEDSPSEYFRTKGWGERVVREIFPETTIVRPAPMFGFEDNLLHKLAGVTNLFTANHMKEKYWPVHAIDVGTALERMAYDDNTASQTFELYGPKQYSTAEIAEIVDKEIVKHRRHINLPKAILKPAAYYLNKYLWWPTISADEVEREFIDQHIDPTAKTFKDLDIEPAEITSLTYLYLMGYRSSQYYDLPPATERERREEKKYLHVLDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBC4</accession>
    <name>B8MBC4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">F1F0 ATP synthase assembly protein Atp11, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_126220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482905.1">
        <property type="nucleotide sequence ID" value="XM_002482860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBC4"/>
    <dbReference type="FunCoup" id="B8MBC4">
        <property type="interactions" value="310"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MBC4"/>
    <dbReference type="GeneID" id="8098134"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_126220"/>
    <dbReference type="eggNOG" id="KOG3281">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054226_1_0_1"/>
    <dbReference type="InParanoid" id="B8MBC4"/>
    <dbReference type="OMA" id="FLQWGFH"/>
    <dbReference type="OrthoDB" id="16535at2759"/>
    <dbReference type="PhylomeDB" id="B8MBC4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010591">
        <property type="entry name" value="ATP11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126:SF0">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126">
        <property type="entry name" value="CHAPERONE ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06644">
        <property type="entry name" value="ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="82"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="84"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED18913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="342" mass="37724" checksum="C236F4CE99EA92D6" modified="2009-03-03" version="1">MASSRVPRLHTLVRTQTQLFQLQQRRWAQVHDVRFLATHRDPQQVLDRYKHKLDQKAKQEGHDSVESLKEAYKDKIAEYRRKASTVATPEPSPASSPTSTKPSPSSTPTHPTASSPIAAAARAATDSNTPGIKPLSSYLNLEKILTLPPKEIETLWRLRHANNARSICAVIPLETYQRMATAARSNPQFILPLPRQSGSTQSEESAAVEGGADIHFLQWGFHPPAASSSSSLQTANTHTSTVVFTHLAAYKLHGSYAQPHTTITHHLDLADEKGLVLMHGQVMPDSGVSVSEASWLVSCVQRFYDFDGEGSGRKGELLRMFTRGDVEGFKIEDLVSETETLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBD0</accession>
    <name>B8MBD0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_126270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482911.1">
        <property type="nucleotide sequence ID" value="XM_002482866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBD0"/>
    <dbReference type="STRING" id="441959.B8MBD0"/>
    <dbReference type="GeneID" id="8098139"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_126270"/>
    <dbReference type="eggNOG" id="ENOG502RPSD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_794775_0_0_1"/>
    <dbReference type="InParanoid" id="B8MBD0"/>
    <dbReference type="OMA" id="RFVFRRN"/>
    <dbReference type="OrthoDB" id="4221626at2759"/>
    <dbReference type="PhylomeDB" id="B8MBD0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="338" mass="38093" checksum="B9B341A534A2E125" modified="2009-03-03" version="1">MSSLRIPGIPYMRGPRGLGRLTAASAFLQLPRSPVKFRRNVRTCDIPSTPVCKLPRRITPDAPRRRGFQATPATSAIPFPSHAPSKPPSPTRYCVWPTPSMSKNGVSRALQNRSYNPSSPLPSRIPVAVDIRSALPVIPCPSALRKRVNFVNPMTAIHANDGSPVKAKSSRRTYHPKPELVARTRLYLKLAQIRKSMVSRSANPLRSILVRPGSEKVAKKKGVRFGPTLIREVNYWIDRKRNVFQDGGLWQMGRLQGWRITPLSTPNEDGETEKYMTMWGHDHNVIECPHEGCVWGSIALFVKYCRLKRMDLGCEGENLMPLWSAYRQKARDAGYDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCB8</accession>
    <name>B8MCB8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_122930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="protein sequence ID" value="EED18564.1"/>
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        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
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            <begin position="21"/>
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        </location>
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    </feature>
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        </location>
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    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED18564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="34619" checksum="C511C4A571AB7F90" modified="2009-03-03" version="1">MELPASLCFATPLMIIRLWRFNYQGTGFGLFYYYLVLFYTDFLSNINRSVAPLSPRLRLSLYELTDSRLQDFSLSTIAIPTASASIFTNTIPISNGQVTTVTITYAPAATSSAGNTTAISSPSDTPTSGNSGDSSSSGSSISSNAQKSSSGLSTGAKIGIGVGAGVGGLAIIGGIIALIVYCCARRRRETTAVGTNIVYAPANNAEDDKADAPVVTPIYHEHKPELDSQQQEQRLQQQVHDQQHNPAGLAAPVSPVSDDPSSTTGRTSELHSESQGYYQSPDGGAQELGAVSSYQHHYQYHLGVVTQAEMPADQGQGHGNTRHELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCJ5</accession>
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        <recommendedName>
            <fullName evidence="1">Berberine/berberine-like domain-containing protein</fullName>
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        <name evidence="2" type="ORF">TSTA_125270</name>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <dbReference type="NCBI Taxonomy" id="441959"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="77"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="148" mass="16984" checksum="0E6CD50CB98F683D" modified="2009-03-03" version="1">MPGLTYPFTAYYEYVGTDVSKIASRLIPRDAWRSALAHILVSIEWSVTSSCEVIHASSLYVIHWMDLLRDIAPDSGAYMSEADILEPHLQDAFYSINYARFYELKQHYDPTGLFFALTAVGAEDWEVQVTDPLPYSWNNSGRLYPRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCY2</accession>
    <name>B8MCY2_TALSN</name>
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        <recommendedName>
            <fullName evidence="4">Protein IBD2</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">TSTA_113340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002481455.1"/>
    </dbReference>
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    <dbReference type="STRING" id="441959.B8MCY2"/>
    <dbReference type="GeneID" id="8101646"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_113340"/>
    <dbReference type="eggNOG" id="ENOG502S317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017965_1_0_1"/>
    <dbReference type="InParanoid" id="B8MCY2"/>
    <dbReference type="OMA" id="LEDIWIC"/>
    <dbReference type="OrthoDB" id="4174342at2759"/>
    <dbReference type="PhylomeDB" id="B8MCY2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="503"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="63500" checksum="A907D735764F298D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCZ7</accession>
    <name>B8MCZ7_TALSN</name>
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        <submittedName>
            <fullName evidence="8">Vacuole-associated enzyme activator complex component (Vac14), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_113490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAC14 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481515.1">
        <property type="nucleotide sequence ID" value="XM_002481470.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="B8MCZ7">
        <property type="interactions" value="892"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MCZ7"/>
    <dbReference type="GeneID" id="8101661"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_113490"/>
    <dbReference type="eggNOG" id="KOG0212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007740_0_0_1"/>
    <dbReference type="InParanoid" id="B8MCZ7"/>
    <dbReference type="OMA" id="QCYQHVS"/>
    <dbReference type="OrthoDB" id="5574975at2759"/>
    <dbReference type="PhylomeDB" id="B8MCZ7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026825">
        <property type="entry name" value="Vac14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021841">
        <property type="entry name" value="VAC14_Fig4p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023:SF0">
        <property type="entry name" value="PROTEIN VAC14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023">
        <property type="entry name" value="TAX1 BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12755">
        <property type="entry name" value="Vac14_Fab1_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11916">
        <property type="entry name" value="Vac14_Fig4_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="5">
        <location>
            <begin position="87"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein 14 C-terminal Fig4-binding" evidence="7">
        <location>
            <begin position="569"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="435"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="756"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="797"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="833"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="455"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="805"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="872"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED17523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="898" mass="99154" checksum="29A017E5B8C52418" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDM5</accession>
    <name>B8MDM5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_120080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482246.1">
        <property type="nucleotide sequence ID" value="XM_002482201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MDM5"/>
    <dbReference type="FunCoup" id="B8MDM5">
        <property type="interactions" value="574"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MDM5"/>
    <dbReference type="GeneID" id="8105282"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_120080"/>
    <dbReference type="eggNOG" id="KOG1765">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065163_2_0_1"/>
    <dbReference type="InParanoid" id="B8MDM5"/>
    <dbReference type="OMA" id="KMVYDEA"/>
    <dbReference type="OrthoDB" id="28455at2759"/>
    <dbReference type="PhylomeDB" id="B8MDM5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="179"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED18254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="217" mass="24466" checksum="C2563FCD85A0107F" modified="2009-03-03" version="1">MATTIEMMDVDTAKPKNTKLPITVTKENPYTFDLGHLLAQDPNPLVISKSESVNNSLKAVARDGAQVLLNQLLTTCPVTSNAKDGVLLSLPPPNTLLPRYKPLPKPKEPTKWELFARKKGIGKYSSKPGAALAEKERRKKLVYDEASGEWVPRWGFKGANKSGENDWVVEVPDKEWKNEAEGKTNVRTMGRAERKERIKRNERKMRANERRSRKFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDR0</accession>
    <name>B8MDR0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sequence orphan</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_120370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482281.1">
        <property type="nucleotide sequence ID" value="XM_002482236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MDR0"/>
    <dbReference type="STRING" id="441959.B8MDR0"/>
    <dbReference type="GeneID" id="8100021"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_120370"/>
    <dbReference type="eggNOG" id="ENOG502QWAD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054095_2_1_1"/>
    <dbReference type="InParanoid" id="B8MDR0"/>
    <dbReference type="OMA" id="RRNWFIS"/>
    <dbReference type="OrthoDB" id="275936at2759"/>
    <dbReference type="PhylomeDB" id="B8MDR0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038781">
        <property type="entry name" value="C365.16-ike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845:SF1">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="35800" checksum="8E0ED854BD7FFD43" modified="2009-03-03" version="1">MSRDATQAKVPAIPISTAKSENKWNTRSLGLRFAADATSAAVAGALICPIITIIDRAIIEKASKGISIRHTLSTCLRSMITKPGGFFLSTPFILIYTLYGGTYLTANAIDTVTSTLRNQPFSTVTPGTAKFLTTTIVNMSICVYKDARFAKLFGPSSDPSTQCHPSAPAVTVATTGASSLSAATATAATIAKQTPTIPKVSYALFCLRDSVTIFASFNIPPLIASSVPDWIVSTPGMKAAVAQFSCPALMQFVSTPMHLLGLDLYNRQPPGGLGWRERLLRIRRDYIVSSFARMGKIVPAYGVGGVVNVRLRAALMEKLQLDDERKHHSLGRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEG9</accession>
    <name>B8MEG9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nucleoside transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_016730</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483832.1">
        <property type="nucleotide sequence ID" value="XM_002483787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEG9"/>
    <dbReference type="FunCoup" id="B8MEG9">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MEG9"/>
    <dbReference type="GeneID" id="8103646"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_016730"/>
    <dbReference type="eggNOG" id="ENOG502QR29">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8MEG9"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="PhylomeDB" id="B8MEG9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF8">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G03000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED16598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="546" mass="60368" checksum="20BDEC81B9C90F24" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEW9</accession>
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        <submittedName>
            <fullName evidence="4">G-protein beta WD-40 repeats containing protein, putative</fullName>
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        <name evidence="4" type="ORF">TSTA_023060</name>
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    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEW9"/>
    <dbReference type="STRING" id="441959.B8MEW9"/>
    <dbReference type="GeneID" id="8101277"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_023060"/>
    <dbReference type="eggNOG" id="KOG0272">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="B8MEW9"/>
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    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="PhylomeDB" id="B8MEW9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
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    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF8">
        <property type="entry name" value="POC1 CENTRIOLAR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
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        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="30"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="104"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="145"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="187"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="229"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="271"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="310"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="357"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
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            <end position="431"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="432"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED17252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="468" mass="49598" checksum="C6D5F7859B81996D" modified="2009-03-03" version="1">MTPNLERVQKSDDSAVNVQNVGSGSCLKTFTGHDDWVNSVAYSSDGTCVASGSVDETVKIWDVDSGNLLKTLKGHGGTVTSVAFSPDGTLEVWDVDGGSCLKTLEGHDGYITSVAFSPDGTRVALGLFSWAVKIWDIGSGSCKEFLGASGTVSSVTFSPDGSRVASASWDSTVKVWDVDGDSCLKTLERHGDYVTSVAFSPDGKCVVSGSRDSTVKIWDVDSGRCLKTLIDHSNPVLSVSFSPAGSRVASSSEDKTVKIWDVDSGSCLKTLEGHGGAVTSVAFSPDGKCVVSGSRDSAVKIWDVTCLKTLEGHRDWIRSVMFSPSGTHIVSLSDDRSIKIWDVDSGACLQTIEHGRVSSVAFSPDGTRMASGSDEKTFKVWDVESGTCSNTYDHSRVRSVAFSPDGTRIASGSDDETAKVWDVNSGNCLMTFKGHSSVVRTVAFSPNGECVASGSHDKKVKIWDAVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8MF66</accession>
    <name>B8MF66_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ureidoglycolate hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_012720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(S)-ureidoglycolate = urea + glyoxylate</text>
            <dbReference type="Rhea" id="RHEA:11304"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="4.3.2.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483399.1">
        <property type="nucleotide sequence ID" value="XM_002483354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MF66"/>
    <dbReference type="FunCoup" id="B8MF66">
        <property type="interactions" value="88"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MF66"/>
    <dbReference type="GeneID" id="8108148"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_012720"/>
    <dbReference type="eggNOG" id="ENOG502S1JQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070848_0_0_1"/>
    <dbReference type="InParanoid" id="B8MF66"/>
    <dbReference type="OMA" id="DCQEVAF"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="PhylomeDB" id="B8MF66"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004848">
        <property type="term" value="F:ureidoglycolate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050385">
        <property type="term" value="F:ureidoglycolate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.480">
        <property type="entry name" value="Ureidoglycolate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007247">
        <property type="entry name" value="Ureidogly_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024060">
        <property type="entry name" value="Ureidoglycolate_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21221">
        <property type="entry name" value="UREIDOGLYCOLATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21221:SF1">
        <property type="entry name" value="UREIDOGLYCOLATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04115">
        <property type="entry name" value="Ureidogly_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="220"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED16165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="335" mass="36794" checksum="4B45437FD549EB0C" modified="2009-03-03" version="1">MAPTLVSSPPTLRINPEPLTPQSFAPFGTVITTPFPRDLLGAPNNLPSLKLPHRVPATPVYANQGSAVKISPIAPLANGYENVCPSGKAAQARLSMFACFPRKLRRERQSAHRLVEHSLKHININEQQDEDNDFEGPVFDVRILERHPYTTQTFIPLDLSSQRRVLRDRVPDKKSHDWKGYGEGDVSITLDGSAEQDEEQEEPMFLVIVAPTLKGQSAAATTLSSSDSTNSSSSSIATLSDPVNEGSADSNRVLIRDPPDLENLRAFIARGGQAVTYGPVLGPRRIDFVVVQYVNGVDDEDCQEAAFKDGIVVDVKSLTEEEDELWNDLKKLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFY1</accession>
    <name>B8MFY1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_009690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483082.1">
        <property type="nucleotide sequence ID" value="XM_002483037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFY1"/>
    <dbReference type="STRING" id="441959.B8MFY1"/>
    <dbReference type="GeneID" id="8102765"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_009690"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_1_1_1"/>
    <dbReference type="InParanoid" id="B8MFY1"/>
    <dbReference type="OMA" id="WMTITIV"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="PhylomeDB" id="B8MFY1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="56"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED15848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="493" mass="53643" checksum="599C72B594D80DAC" modified="2009-03-03" version="1">MAQPASSNDVEDLAVPTTDKIATEKDDDEDVNLVDWDGPDDPANPVNWSNMQKWTVIGLVSFNTFNASMASSIFAPGVPQAMQDFHSNSSILFTFVVSVFIVGFIIGPLLLTPASELYGRMPVTHSANIIFLVASILCAVSVNIPMLIVFRLIMGLSGCVPVTLGAGFIADLMPVEKRGMALAIWTFGPLVGPVIGPVIGGYMALGTTWRWTFWLITILGAAATIASFLFMRETYVPIILERKAKALRKSTGGNMRTKYDKGQTLRQLIGAAVTRPLRMLIRSPIVLILSLYISIVYSYLYLLLTTYTEIFEGVYGFNSGEAGLAYLGLGVGFISGQVAIGPFSDRYIKLQRKRRGSVQPEDRLPPLLLGSCLVPIGLFCYGWSAEARTHWIVPIVGTCIFSAGVEFTFFPIQMYLIDAFTIHAASAVAANTVVRSIFGALVPLAGNPLYDTLGLGWGNSLLAFISIAFVPFSLVLLKYGARIRTNPRFQASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGB6</accession>
    <name>B8MGB6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_013390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483470.1">
        <property type="nucleotide sequence ID" value="XM_002483425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGB6"/>
    <dbReference type="GeneID" id="8107801"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_013390"/>
    <dbReference type="eggNOG" id="ENOG502S9HK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050866_1_1_1"/>
    <dbReference type="InParanoid" id="B8MGB6"/>
    <dbReference type="OMA" id="MECNEYS"/>
    <dbReference type="OrthoDB" id="9970474at2759"/>
    <dbReference type="PhylomeDB" id="B8MGB6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40518">
        <property type="entry name" value="ACETOACETATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40518:SF1">
        <property type="entry name" value="ACETOACETATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED16236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="252" mass="28295" checksum="D15F957DD0F34C58" modified="2009-03-03" version="1">MSRTFYKMCSTPLVSPHVHSDTLRKLDNGKSQLNGIGRLLKFLAIIRYEDTDVGPYDELIVMPGMSVNPHSGTRHARISNIYVSTDTSVWNGRRNWNIPKHRARFVFEQVGRQDQILKLYHPEDSAAPLDPKGTFFTALLKGSALPKWTLPAFSPGGLVQPPLPPPRYRSQSATTAAVIATDDPGNGRENPWLMIHPSYRGSWGLTYISKVPPSINDEESLEWYGDGISLPKMKVWSVGGYFEGNIAFQRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGJ4</accession>
    <name>B8MGJ4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_018170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483979.1">
        <property type="nucleotide sequence ID" value="XM_002483934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGJ4"/>
    <dbReference type="GeneID" id="8100927"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_018170"/>
    <dbReference type="eggNOG" id="ENOG502SYIX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071883_1_0_1"/>
    <dbReference type="InParanoid" id="B8MGJ4"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="PhylomeDB" id="B8MGJ4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="149"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED16745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="265" mass="30356" checksum="2CB72117FBC0B612" modified="2009-03-03" version="1">MKPEKNKVSRITIACNPCRSRKQKKSSILELTLCRPECEQCSSYNRTCEWPEQLKRGPPKGYVEALEQRLHETEDVLLKVLSQLNEAQLTSILSAPNAFPVDDVPQDNGTPNRFPMLHARNRGVEHWKSFPLRDAESIRKWQQDFHRIRSTSSSSLPNENHWRSSRPSRRRSSRKNARVDSGSAENLPNAQSPIDELPSEANGKFQDSNLYSRRTVNGGTSGNRPLRPKMNFHIPAPTNQHESNSSHLSSWNAAPSKEFQEQFMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MH91</accession>
    <name>B8MH91_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc metallopeptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_021310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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    </dbReference>
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        <location>
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        </location>
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        </location>
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        </location>
    </feature>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED17070.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="789" mass="86785" checksum="3C12588557EB1577" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
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            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        </location>
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        </location>
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        <location>
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        </location>
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        </location>
    </feature>
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        <location>
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            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED17097.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1096" mass="117871" checksum="E867EC39DE806F48" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHD0</accession>
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    </gene>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    <dbReference type="PhylomeDB" id="B8MHD0"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED17109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23180" checksum="83A0127453956720" modified="2009-03-03" version="1">MTIGLHQWRECSPFAEPKEVTLERRFVPQEIYGANIDEKIVQVPVHKWVFLACENASRCWSHNLPAHTDCLVIAVNGACQRNAAGKVETPLGCMLARIAHTTSGINIDVEDAGRAGGHVAELHAALYGLQQAAATAWEREMSEERDSGRPSMIAIKSDSPYLILAWEKNGYRTTKGTPVVHTELCEKLEAAYWSLCGAHESRRVYIYF</sequence>
</entry>
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        </submittedName>
    </protein>
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    </gene>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002483186.1"/>
    </dbReference>
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    <dbReference type="STRING" id="441959.B8MHL6"/>
    <dbReference type="GeneID" id="8109884"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_011110"/>
    <dbReference type="eggNOG" id="KOG1827">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012767_0_0_1"/>
    <dbReference type="InParanoid" id="B8MHL6"/>
    <dbReference type="OMA" id="LWTNAYF"/>
    <dbReference type="OrthoDB" id="6017at2759"/>
    <dbReference type="PhylomeDB" id="B8MHL6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054551">
        <property type="entry name" value="RSC4_Ig-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF19">
        <property type="entry name" value="PROTEIN POLYBROMO-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22994">
        <property type="entry name" value="RSC4_Ig_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="57"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="236"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="142"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="365"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="372"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED15997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="619" mass="69086" checksum="4AB7D066C8DF6C91" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHV3</accession>
    <name>B8MHV3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_015210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483667.1">
        <property type="nucleotide sequence ID" value="XM_002483622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHV3"/>
    <dbReference type="STRING" id="441959.B8MHV3"/>
    <dbReference type="GeneID" id="8106263"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_015210"/>
    <dbReference type="eggNOG" id="ENOG502S356">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025951_1_0_1"/>
    <dbReference type="InParanoid" id="B8MHV3"/>
    <dbReference type="OMA" id="ACHVRYF"/>
    <dbReference type="OrthoDB" id="4179303at2759"/>
    <dbReference type="PhylomeDB" id="B8MHV3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="522" mass="60504" checksum="990279E042332D6D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJ85</accession>
    <name>B8MJ85_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_041520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484627.1">
        <property type="nucleotide sequence ID" value="XM_002484582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJ85"/>
    <dbReference type="STRING" id="441959.B8MJ85"/>
    <dbReference type="GeneID" id="8109737"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_041520"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="InParanoid" id="B8MJ85"/>
    <dbReference type="OMA" id="NAICPFY"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="PhylomeDB" id="B8MJ85"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF115">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED14674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="289" mass="31042" checksum="5BB99E67D9F2F4EC" modified="2009-03-03" version="1">MELHADPLSHIYCHISQFEAMLRLDGKVVLITGLGQTTDEGWGIGAAIASKLASQGAMIFGGNRSLASAQRTKSRIDSSGGICDIQETNVTEANSVKALVEACMQRHGRIDILVNNVGRSEPGCPATMTEDIWDSQVDINLKSVYLTCHLVLPIMERQTSGGSIINVSSIAGLRYIGKPQVAYSATKAAIMQFTTATAVIYAAKNVRLNTVVPGLISTPYTRELAKRYAPGGDEEEYMRKRDAQVPMGRMGDAWDVANAVLFLAADESKYITGQELVVDGGITSSTGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJ98</accession>
    <name>B8MJ98_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_041650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484640.1">
        <property type="nucleotide sequence ID" value="XM_002484595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJ98"/>
    <dbReference type="ESTHER" id="talsn-b8mj98">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="8102942"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_041650"/>
    <dbReference type="eggNOG" id="ENOG502S15T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046066_1_3_1"/>
    <dbReference type="InParanoid" id="B8MJ98"/>
    <dbReference type="OMA" id="FCAGAWY"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="PhylomeDB" id="B8MJ98"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="9"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="280" mass="29820" checksum="18CB9E19270B4CF0" modified="2009-03-03" version="1">MASSNKPTVLFVHGAFHGPDCFDALISPLKAADYFGSIKNNLKLPSAELNSSSSLQQDIDVLRAEVLKVLDGPTVTNGPRGGSDCVVVMHSYGAVPAAEALRGLGRSERGVGNTAVVKMVYLSCNIPKAGDSHVGQLTAWIAERGLSADLPLEPLDNGILKFTGAADVFYNGLPEDQQASLIASLSTQSAAVLTTPLKGSVGSMAYDEIPGWYLLCKNDNILPEAFQRECIRVVRDGMERVEEVDAGHSSFMVVPEIVADFILRAAKSGNSQRGTQHHII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJA5</accession>
    <name>B8MJA5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_041710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484647.1">
        <property type="nucleotide sequence ID" value="XM_002484602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJA5"/>
    <dbReference type="GeneID" id="8102948"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_041710"/>
    <dbReference type="HOGENOM" id="CLU_2110593_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJA5"/>
    <dbReference type="OrthoDB" id="4499077at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED14694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="13099" checksum="26713E376185DECD" modified="2009-03-03" version="1">MEDCGSFISTWTEMGLSMNQENIIHSYNTIAERIVTNTWDETSHPVTLACFLSLQALFSSKVDITNTRNSKGQTRFHIAAHYNIDIVSILINRNTDVNARRNDGQKIWALVCCFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJB4</accession>
    <name>B8MJB4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-dehydrosphinganine reductase</fullName>
            <ecNumber evidence="9">1.1.1.102</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_041790</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reduction of 3'-oxosphinganine (3-ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>sphinganine + NADP(+) = 3-oxosphinganine + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.102"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:22642"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.1.1.102" evidence="9"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484656.1">
        <property type="nucleotide sequence ID" value="XM_002484611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJB4"/>
    <dbReference type="FunCoup" id="B8MJB4">
        <property type="interactions" value="133"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MJB4"/>
    <dbReference type="GeneID" id="8102956"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_041790"/>
    <dbReference type="eggNOG" id="KOG1210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_3_3_1"/>
    <dbReference type="InParanoid" id="B8MJB4"/>
    <dbReference type="OMA" id="ESHVNIQ"/>
    <dbReference type="OrthoDB" id="10267115at2759"/>
    <dbReference type="PhylomeDB" id="B8MJB4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08939">
        <property type="entry name" value="KDSR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045022">
        <property type="entry name" value="KDSR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED14703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="312" mass="34945" checksum="6C91C34376309745" modified="2009-03-03" version="1">MFGRTNFDPLGQSVIIAGGSKGLGRELALQLADRGANVAILGRTPKALEETLQDLQQKIKGPDQKHSSTVLDLTDAAQVTNYIDSLPEPPSILFCVAGGTASEIGFFADIAAEDIRSCMERNYFAAAFIAHAVLKQWLARPPPFKQRRHIVFTASTAAFVGLPGYTAYTPTKTATRALADTLRQEVLLYRSQQDIRVHCSFPGTIYTDAFYEEQTRKPDLLKELEGSNKENSGLTAARAAELTIEGLKQGRFFITMDMETELLLNNMRGPSPRYWSVWDWILGLLASLVWPVFRIMHDRKTSQYRREQRKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJI0</accession>
    <name>B8MJI0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine-protein kinase ripk4, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_046340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485133.1">
        <property type="nucleotide sequence ID" value="XM_002485088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJI0"/>
    <dbReference type="STRING" id="441959.B8MJI0"/>
    <dbReference type="GeneID" id="8099545"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_046340"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_816783_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJI0"/>
    <dbReference type="OMA" id="NCINIPD"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="PhylomeDB" id="B8MJI0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051070">
        <property type="entry name" value="NF-kappa-B_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680:SF3">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR CACTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="105"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="141"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED15180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="340" mass="37710" checksum="1A0D2E45928C8EA6" modified="2009-03-03" version="1">MVQIHISWTPEEYQPPQKPSWSAKMDDLMTETSVTDDLCFTPLHHVVIGLEKADVYQQLRLNNNCINIPDSLGRSPLHWAVIQGNTSIIAALLEHGAFPGSRDKEQMTPLHEVCRAPQSSQAACARLLIDSGADVDARDSWGRTALRIAVGFTNTSPDLIEILLEEGADVNDSDIYGQTPLLKSIRAQSCIMELLLKHGASTEATDIYGNTPLSEAIYRNSAEQLNLLMKYGSKTNQLLDLQPGRRAREGRINILHFTAWYGGIEVMRALESSEQYLCRSPDPIDDFVQYKEVRLAHGLGVGKEEYEAFVHLLSTVKYSCEGGDEDEKDDPEGSVGSSCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJL6</accession>
    <name>B8MJL6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_046690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485169.1">
        <property type="nucleotide sequence ID" value="XM_002485124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJL6"/>
    <dbReference type="STRING" id="441959.B8MJL6"/>
    <dbReference type="GeneID" id="8108033"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_046690"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="InParanoid" id="B8MJL6"/>
    <dbReference type="OMA" id="MCFAIGQ"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="PhylomeDB" id="B8MJL6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF83">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED15216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="530" mass="60013" checksum="3B59FB80CB64BDF0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJL7</accession>
    <name>B8MJL7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_046700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="3"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485170.1">
        <property type="nucleotide sequence ID" value="XM_002485125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJL7"/>
    <dbReference type="STRING" id="441959.B8MJL7"/>
    <dbReference type="GeneID" id="8108034"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_046700"/>
    <dbReference type="eggNOG" id="ENOG502RS2Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018331_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJL7"/>
    <dbReference type="OMA" id="AGWYADD"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="PhylomeDB" id="B8MJL7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.60">
        <property type="entry name" value="alpha-galactosidase from lactobacil brevis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038417">
        <property type="entry name" value="Alpga-gal_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050985">
        <property type="entry name" value="Alpha-glycosidase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031704">
        <property type="entry name" value="Glyco_hydro_36_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053:SF3">
        <property type="entry name" value="ALPHA-GALACTOSIDASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053">
        <property type="entry name" value="GLYCOSIDASE FAMILY 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16875">
        <property type="entry name" value="Glyco_hydro_36N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02065">
        <property type="entry name" value="Melibiase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00743">
        <property type="entry name" value="GLHYDRLASE36"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 36 N-terminal" evidence="6">
        <location>
            <begin position="67"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED15217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="700" mass="77888" checksum="076989E0EBB2C344" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8MK54</accession>
    <name>B8MK54_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Probable beta-glucosidase G</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Beta-D-glucoside glucohydrolase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Cellobiase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Gentiobiase G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TSTA_043460</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484824.1">
        <property type="nucleotide sequence ID" value="XM_002484779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MK54"/>
    <dbReference type="STRING" id="441959.B8MK54"/>
    <dbReference type="GeneID" id="8097854"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_043460"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_2_3_1"/>
    <dbReference type="InParanoid" id="B8MK54"/>
    <dbReference type="OMA" id="PFGGRNW"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="PhylomeDB" id="B8MK54"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF12">
        <property type="entry name" value="BETA-GLUCOSIDASE G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 21" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fibronectin type III-like" evidence="20">
        <location>
            <begin position="588"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EED14871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="674" mass="72922" checksum="BB0092B96D60E298" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKR1</accession>
    <name>B8MKR1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetoacetyl-CoA synthase</fullName>
            <ecNumber evidence="7">6.2.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_043800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.16" evidence="7"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484863.1">
        <property type="nucleotide sequence ID" value="XM_002484818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKR1"/>
    <dbReference type="STRING" id="441959.B8MKR1"/>
    <dbReference type="GeneID" id="8097888"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_043800"/>
    <dbReference type="eggNOG" id="KOG1175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_3_1"/>
    <dbReference type="InParanoid" id="B8MKR1"/>
    <dbReference type="OMA" id="DWYREWA"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="PhylomeDB" id="B8MKR1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002937">
        <property type="entry name" value="PRK03584.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF1">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="6">
        <location>
            <begin position="42"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="111"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED14910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="696" mass="76948" checksum="7B98117A27E425D4" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKS5</accession>
    <name>B8MKS5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell wall biogenesis protein Ecm15, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_043930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484877.1">
        <property type="nucleotide sequence ID" value="XM_002484832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKS5"/>
    <dbReference type="FunCoup" id="B8MKS5">
        <property type="interactions" value="42"/>
    </dbReference>
    <dbReference type="GeneID" id="8097901"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_043930"/>
    <dbReference type="eggNOG" id="ENOG502S45I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137479_0_0_1"/>
    <dbReference type="InParanoid" id="B8MKS5"/>
    <dbReference type="OMA" id="RVIGQCH"/>
    <dbReference type="OrthoDB" id="5587367at2759"/>
    <dbReference type="PhylomeDB" id="B8MKS5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051614">
        <property type="entry name" value="UPF0045_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00106">
        <property type="entry name" value="MTH1187 family thiamine-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777:SF1">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="MTH1187/YkoF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine-binding protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED14924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="114" mass="12248" checksum="8507630848088B11" modified="2009-03-03" version="1">MSSSSIESIPTPDHCTADFCLIPIGTGSASVSAQIADVQRLIEKSGLKYVMHSAGTTLEGPWDKVHHVIGQAHTILHQQGVVRIQSDIRSGSRVDKVQSFEDKVAAVNKLLGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8ML53</accession>
    <name>B8ML53_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_049090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485422.1">
        <property type="nucleotide sequence ID" value="XM_002485377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ML53"/>
    <dbReference type="STRING" id="441959.B8ML53"/>
    <dbReference type="GeneID" id="8100625"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_049090"/>
    <dbReference type="HOGENOM" id="CLU_1476087_0_0_1"/>
    <dbReference type="InParanoid" id="B8ML53"/>
    <dbReference type="OrthoDB" id="10400344at2759"/>
    <dbReference type="PhylomeDB" id="B8ML53"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="183" mass="20387" checksum="768F0FBBCCB833B5" modified="2009-03-03" version="1">MESRPPSIPHPPFPRPSLFSAAPQHSRQYGSSQQPPSRPEARSQTTYDSLNRPADEPSRVMPTYNYAAHSYNPDLRSQTRSTSPTRFGAMQSDPAKRSALASPVKNNGILGKDSAFYRDALNTPYPLLFRLDTSPTSCCFAYTNLSLYKALFLETATYTETISRAIVLDSGVVFWQICVTRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLA6</accession>
    <name>B8MLA6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_044850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484974.1">
        <property type="nucleotide sequence ID" value="XM_002484929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLA6"/>
    <dbReference type="STRING" id="441959.B8MLA6"/>
    <dbReference type="GeneID" id="8104161"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_044850"/>
    <dbReference type="eggNOG" id="ENOG502R8TH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_601441_0_0_1"/>
    <dbReference type="InParanoid" id="B8MLA6"/>
    <dbReference type="OMA" id="NFYYLTS"/>
    <dbReference type="OrthoDB" id="250175at2759"/>
    <dbReference type="PhylomeDB" id="B8MLA6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED15021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="450" mass="52036" checksum="38472F88707F03F1" modified="2009-03-03" version="1">MSLHRSSQILRPLCQSCARRPSLLPSSTIPTTTNIIRTPATTRNYTATSNYQAKRPLRSPAAKSLNRTYGKEFSVVEPEEWWAEHDGVKKRFEKNYATIYADNRRAKVFREIGRRLIHAAYNSPATAESLKPIWAGDPARVLDVALAIFSSAPWETHVVRWSVAATSEAGVVWSMIQFVHSQIKKHGTNLPNSREIERIKKIAYEKDDPVALMVWGDVAWRWGRKDEALEIFQYLNKIAYPSFSPAERNNDITYEGHYQAPWKYLVEIHNEAGRYDEADELMKLGALTYRDPAALVSYAYIRKEKGDWESYEQCLVVAAMTGHGEACFRLGNYYYRIYKGEVPSREDIAAKKHPIRTWFVDLFGWFTLTKKDWRRLAINWYEMASALGYMPGTRNLVVLLREDGHESATEILDRIKLDYVMWNSKNIVKLRKSWDDPNFKPDLPAAWLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLU9</accession>
    <name>B8MLU9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amine oxidase, flavin-containing superfamily</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_101150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486113.1">
        <property type="nucleotide sequence ID" value="XM_002486068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLU9"/>
    <dbReference type="GeneID" id="8101803"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_101150"/>
    <dbReference type="eggNOG" id="ENOG502SIR2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028280_0_0_1"/>
    <dbReference type="InParanoid" id="B8MLU9"/>
    <dbReference type="OMA" id="NFQTTLW"/>
    <dbReference type="OrthoDB" id="68575at2759"/>
    <dbReference type="PhylomeDB" id="B8MLU9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002875322" description="Amine oxidase, flavin-containing superfamily" evidence="1">
        <location>
            <begin position="23"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="52362" checksum="850F21A83226D656" modified="2009-03-03" version="1">MLSLRTASLWLMIAAATGGAIALELPNFLTKDVVIIGGGASGAYAGVRLRDDFNKSIAIVEMQDRLGGMVNTYIDPATGTPYDYGVQSFLDLGNATGFFERFGIETAPLSQTNVTTEHIDFNTGAVVNLTLPSFPDQVTALQKFLDVVKPWTDYLQPGYWNFPQPADIPEDFLIPFGDFITKYGLEDAIPLIYETTGLGLGNMTQATTMFELQAFGTYMAQAMTGQLNSYHPSSGGNQALYNAIQKDLGDDVLYNSTVIRSLRTKWGVLLTVQNHATGHATLITARQLLIAIEPTDQNLAPFDLDDNERTVLSKFTYTKEYSGIVNNSAFAPGMSYTNMAAGAAPDKYLILPNFPFTNEVSYIGGDNLFRVIIAGDDTLDEASAKTLMQKNFETLLKAGRLAEPYNGQQIEWVSFSNHGPMHARVSVEDVQAGLFQDLNALQGQRSTWWTGGAFSCNFQTTLWEFDETLIPKILANLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMB4</accession>
    <name>B8MMB4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_099210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485906.1">
        <property type="nucleotide sequence ID" value="XM_002485861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMB4"/>
    <dbReference type="GeneID" id="8103999"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_099210"/>
    <dbReference type="eggNOG" id="ENOG502SYA6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057536_0_0_1"/>
    <dbReference type="InParanoid" id="B8MMB4"/>
    <dbReference type="OMA" id="RPPHVIE"/>
    <dbReference type="OrthoDB" id="5384804at2759"/>
    <dbReference type="PhylomeDB" id="B8MMB4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="452" mass="53095" checksum="2A9523AF5BA3AACA" modified="2009-03-03" version="1">MSRLINFPSELLILVYSFLDNIDDALHLARTCKFMYNVLDTPGRRLDIFSKIIMAINVDKIIKQNGDHHRYDLRLHATETICTNFRNEHYNTSDLPSISDRPLFPTEFLVPDTNTLYKKLDPDTVWSIISRWHALKLLFSLYFDSTIRPSYLRSVFWQRPDCQHSRWQKAVDYEIPLEPPSGQTCTTLRDMSSTDKAEAYTRFYRAITSHWLHINLTWLAGISKYPDRPSCDSTFSQIDSLWYNDRERATLIQKLEAIEVTDFIWGFLARKIFADPDQIDSWISSPGHLDNETILWDVPLDASSFARLVRIATFYLPPPHIIELLVDMWASPEPGGRLNKRDYIQKLGFFDTKHGVLEQDGEQVIVFSWFSTEIMFMIEWVGVDWTLKDKGISLQLGMMSSVDDPLVYTQWRRYRVSRWIDDFRGKCILFPETEEEIIKRIEQNQPPSIQPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMV1</accession>
    <name>B8MMV1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_101070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="2"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="8101795"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_101070"/>
    <dbReference type="eggNOG" id="KOG3981">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_053595_0_1_1"/>
    <dbReference type="InParanoid" id="B8MMV1"/>
    <dbReference type="OMA" id="MNACIPP"/>
    <dbReference type="OrthoDB" id="70823at2759"/>
    <dbReference type="PhylomeDB" id="B8MMV1"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:carbohydrate catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
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        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
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        <property type="entry name" value="DeoC"/>
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        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Aldolase"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED13867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="267" mass="28498" checksum="59AF49B107355CF0" modified="2009-03-03" version="1">MATKLETPNTDIEWAAFISTIKDDLPDTHTVYHTPLPHAVAHTIDHTQLSPSATSSDIDNLCSEAREHKFATVCVPHNLADIKNEVGIACVVGFHEGTYPTAEKVEEATKAVAEGATELDMVLNWPLLKQGKYTDVYNDILAVRRAAPAPKTKLKVILETSQLSRDEIIAGSAISDMAGANYVKTSTGFNGTGATIENVRLMREVVDMLANGCKVKASGGVRSAEEAVEMLKAGADRIGASAGVKIVRELTGNALRPNVSTPIGGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMZ2</accession>
    <name>B8MMZ2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase, putative</fullName>
            <ecNumber evidence="3">2.3.1.161</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_101770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED13941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002486134.1"/>
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    <dbReference type="AlphaFoldDB" id="B8MMZ2"/>
    <dbReference type="STRING" id="441959.B8MMZ2"/>
    <dbReference type="GeneID" id="8099222"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_101770"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_311256_0_0_1"/>
    <dbReference type="InParanoid" id="B8MMZ2"/>
    <dbReference type="OrthoDB" id="4455258at2759"/>
    <dbReference type="PhylomeDB" id="B8MMZ2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:lovastatin nonaketide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050444">
        <property type="entry name" value="Polyketide_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681:SF6">
        <property type="entry name" value="POLYKETIDE SYNTHASE 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681">
        <property type="entry name" value="POLYKETIDE SYNTHASE 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="2">
        <location>
            <begin position="167"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED13941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="944" mass="104780" checksum="90F392D1CD88B360" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MN18</accession>
    <name>B8MN18_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Efflux pump antibiotic resistance protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_102020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486205.1">
        <property type="nucleotide sequence ID" value="XM_002486160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MN18"/>
    <dbReference type="FunCoup" id="B8MN18">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="GeneID" id="8099247"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_102020"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8MN18"/>
    <dbReference type="OMA" id="YYVPYMI"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="PhylomeDB" id="B8MN18"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="111"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED13967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="642" mass="69969" checksum="09DFAA670D51F7E3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNC3</accession>
    <name>B8MNC3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyhydroxybutyrate depolymerase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_102420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486250.1">
        <property type="nucleotide sequence ID" value="XM_002486205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNC3"/>
    <dbReference type="STRING" id="441959.B8MNC3"/>
    <dbReference type="GeneID" id="8100819"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_102420"/>
    <dbReference type="eggNOG" id="ENOG502RYCJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042524_0_0_1"/>
    <dbReference type="InParanoid" id="B8MNC3"/>
    <dbReference type="OMA" id="YMAGQFQ"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="PhylomeDB" id="B8MNC3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42972:SF8">
        <property type="entry name" value="POLYHYDROXYBUTYRATE DEPOLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42972">
        <property type="entry name" value="TOL-PAL SYSTEM PROTEIN TOLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039239850" evidence="1">
        <location>
            <begin position="21"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="355" mass="37003" checksum="F73071E23191CC2E" modified="2009-03-03" version="1">MFDLATVAWFAVLGASGASATALPAFNVNPNSISVSGLSSGGYMAAQLGVAYSDVFNLGFGVFAGGPYDCARNQYYTSCMYNANPSITTPIANMNAWSGNQIAKVANLEQRKIYMWVGSADTTVGPNVMNQLKVQLANFDEAANVSYVTTSGAAHTFPTDFSGSGDNACSSASSPYISNCNYDGAGAALQWIYGSLNAKNTGTLTGSVVSFDQSGSFGANGMDTTGYLYVPQSCASGATTCSLHVALHGCLQSYSSIGSKFVQNTGYNKWADTNNIIILYPQAIPDNTIHSIWYGGVLSNPNGCWDWVGWYGSNADQIGGVQMAAIVSQVKQIVSGFKGTNTTPTTSSTPAGCTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNI8</accession>
    <name>B8MNI8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cation diffusion facilitator, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_103040</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486315.1">
        <property type="nucleotide sequence ID" value="XM_002486270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNI8"/>
    <dbReference type="STRING" id="441959.B8MNI8"/>
    <dbReference type="GeneID" id="8102923"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_103040"/>
    <dbReference type="eggNOG" id="KOG1485">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_10_0_1"/>
    <dbReference type="InParanoid" id="B8MNI8"/>
    <dbReference type="OMA" id="KKPIREY"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="PhylomeDB" id="B8MNI8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000004">
        <property type="entry name" value="Cation diffusion facilitator 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF4">
        <property type="entry name" value="CDF DIVALENT METAL CATION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="244"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="9">
        <location>
            <begin position="461"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="174"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED14077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="530" mass="60322" checksum="DEE4064192708216" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNQ0</accession>
    <name>B8MNQ0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TBP interacting domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_103600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486377.1">
        <property type="nucleotide sequence ID" value="XM_002486332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNQ0"/>
    <dbReference type="STRING" id="441959.B8MNQ0"/>
    <dbReference type="GeneID" id="8103063"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_103600"/>
    <dbReference type="eggNOG" id="KOG4603">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063266_3_1_1"/>
    <dbReference type="InParanoid" id="B8MNQ0"/>
    <dbReference type="OrthoDB" id="272266at2759"/>
    <dbReference type="PhylomeDB" id="B8MNQ0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120231">
        <property type="term" value="C:DNA recombinase auxiliary factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120230">
        <property type="term" value="F:recombinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010774">
        <property type="term" value="P:meiotic strand invasion involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938:SF0">
        <property type="entry name" value="HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938">
        <property type="entry name" value="TBP-1 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED14139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="156" mass="17739" checksum="A70685C5CE658690" modified="2009-03-03" version="1">MADVSIGKQIVYHAIQQIESDDATGTDGPDPDQNNKDLEEKISILKIREKDLREKLATLNAVIPISVLKDQISNLEEKKTLLISQISTLSAEMEESNSCVCKEDFDQIDQEWRKWHGQVTSRKRIFLEFWSSCTEVLPPDMTPEDLKETLGIEGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MP28</accession>
    <name>B8MP28_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosome associated DnaJ chaperone Zuotin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_104810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486505.1">
        <property type="nucleotide sequence ID" value="XM_002486460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MP28"/>
    <dbReference type="FunCoup" id="B8MP28">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MP28"/>
    <dbReference type="GeneID" id="8098702"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_104810"/>
    <dbReference type="eggNOG" id="KOG0724">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019916_1_0_1"/>
    <dbReference type="InParanoid" id="B8MP28"/>
    <dbReference type="OMA" id="RNHTWSE"/>
    <dbReference type="OrthoDB" id="1690618at2759"/>
    <dbReference type="PhylomeDB" id="B8MP28"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006452">
        <property type="term" value="P:translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23953">
        <property type="entry name" value="zuotin_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.840">
        <property type="entry name" value="Ribosome-associated complex head domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032003">
        <property type="entry name" value="RAC_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042569">
        <property type="entry name" value="RAC_head_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044634">
        <property type="entry name" value="Zuotin/DnaJC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058871">
        <property type="entry name" value="Zuotin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16717">
        <property type="entry name" value="RAC_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26185">
        <property type="entry name" value="Zuotin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="101"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="45"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="243"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="319"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="319"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED14267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="447" mass="51388" checksum="1441892B8A4AF9E8" modified="2009-03-03" version="1">MATVTSPLPPLPPLPAGWSAEKDYKVLSSLTSAVQRNIEPVGPHFLAHARRKRHNRTFSEDERIQAQKNVKKVDEDEDDEISEPEDPLMLQRDAKDWKNQDHYAVLGLSKYRYKATPEQIKRAHRKKVLRHHPDKKAAAGQTDENDNFFKCIQKATEILLDPAKRRQYDSCDENANVEPPTKKQLEKGNYYKLWDRVFKSEARFSNKQPVPTFGSENSTEEEVEEFYNFWYNFDSWRSFEYEDEDVPDDNENRDQKRHVERKNANSRRKKKTEDTTRLRKLVDDALAGDERIKKFRQAKRAGKDKKRLEKEAEAKRIAEEKEKAKQEEERKKKEAEEAAKAEREANKKSKEAAKNAAKKNKRVLRNSVKDVNYFAEGGDASASQVDNVLNDVDAIMAKITPEELAALASKLTSAGTDAAAVKAAYVDEVKRLIGEGKLKETEIKALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MP43</accession>
    <name>B8MP43_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_104960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486520.1">
        <property type="nucleotide sequence ID" value="XM_002486475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MP43"/>
    <dbReference type="STRING" id="441959.B8MP43"/>
    <dbReference type="GeneID" id="8098717"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_104960"/>
    <dbReference type="eggNOG" id="ENOG502SD0J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_463203_0_0_1"/>
    <dbReference type="InParanoid" id="B8MP43"/>
    <dbReference type="OMA" id="HRHGNSQ"/>
    <dbReference type="OrthoDB" id="5404004at2759"/>
    <dbReference type="PhylomeDB" id="B8MP43"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="680" mass="73508" checksum="524D215FC174691A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPG2</accession>
    <name>B8MPG2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_106100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486639.1">
        <property type="nucleotide sequence ID" value="XM_002486594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPG2"/>
    <dbReference type="STRING" id="441959.B8MPG2"/>
    <dbReference type="GeneID" id="8100469"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_106100"/>
    <dbReference type="eggNOG" id="ENOG502S8V9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115019_2_0_1"/>
    <dbReference type="InParanoid" id="B8MPG2"/>
    <dbReference type="OMA" id="MVWINIS"/>
    <dbReference type="OrthoDB" id="2519291at2759"/>
    <dbReference type="PhylomeDB" id="B8MPG2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="42"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED14401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="170" mass="18972" checksum="A425BB33D4ED3EEA" modified="2009-03-03" version="1">MPPSTRLKNILFIASFLTFNITVPTLNSKMTLIRVVVFTYRKSGLTLEEFKSYSEQHGHLLKRLASDVFPISHRRSYIAREEKGSDADATETTARNPTTPAKLFLGQQSDFDFDAYTELTFASQEAVQAYVAKTSQPDIAATIAADEEKFLDRPKTGIVFLGDVTEVNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2024-05-29" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPV0</accession>
    <name>B8MPV0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_052790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486869.1">
        <property type="nucleotide sequence ID" value="XM_002486824.1"/>
    </dbReference>
    <dbReference type="GeneID" id="8098228"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_052790"/>
    <dbReference type="HOGENOM" id="CLU_2639777_0_0_1"/>
    <dbReference type="InParanoid" id="B8MPV0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED12758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="77" mass="8804" checksum="1A3919CE61D14DBC" modified="2009-03-03" version="1">MSEREYQTLHVLAPDISTYATITQYAPVKSTPTTHSKAHVXXTQGTDLVTQTTQLTWQSQHLLLLTAKHYQTHYKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPV4</accession>
    <name>B8MPV4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_052830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486873.1">
        <property type="nucleotide sequence ID" value="XM_002486828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPV4"/>
    <dbReference type="STRING" id="441959.B8MPV4"/>
    <dbReference type="GeneID" id="8098232"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_052830"/>
    <dbReference type="HOGENOM" id="CLU_1084005_0_0_1"/>
    <dbReference type="InParanoid" id="B8MPV4"/>
    <dbReference type="PhylomeDB" id="B8MPV4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="257" mass="28973" checksum="7CDD0CC517CC4C5C" modified="2009-03-03" version="1" fragment="single">ERADSKRHYLDHFNKRIDQYIADYEGTGDDNDEELPEELLLAADDLILTDDYESRPIHDASSTLFTATFFTTHKDNNTNYGPSITMELANCSTSHWIASLFLKPNLETNSYKTNEVTLKVLTPESSHVYLNEGRYSSESFKGIVINTGAAQLSTAGYGQYLAYKRIVRNIDINTTMAGTATVQFGPGDPYQSIGSIDVPIPISTIWFYILTTTTLFLISLYELDRLKLYFDNTCNLLVNKKMGKTTPVICQFGHPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQZ8</accession>
    <name>B8MQZ8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA polymerase</fullName>
            <ecNumber evidence="20">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">TSTA_053510</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19 20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="20"/>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486944.1">
        <property type="nucleotide sequence ID" value="XM_002486899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQZ8"/>
    <dbReference type="FunCoup" id="B8MQZ8">
        <property type="interactions" value="770"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MQZ8"/>
    <dbReference type="GeneID" id="8098302"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_053510"/>
    <dbReference type="eggNOG" id="KOG0969">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000203_2_0_1"/>
    <dbReference type="InParanoid" id="B8MQZ8"/>
    <dbReference type="OMA" id="CNNCRPR"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="PhylomeDB" id="B8MQZ8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05777">
        <property type="entry name" value="DNA_polB_delta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05533">
        <property type="entry name" value="POLBc_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.342.10:FF:000009">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 20" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 20" id="KW-0235">DNA replication</keyword>
    <keyword evidence="17 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14 20" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 20" id="KW-0408">Iron</keyword>
    <keyword evidence="16 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 20" id="KW-0479">Metal-binding</keyword>
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</entry>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="344" mass="39799" checksum="281A63BC2AF9CB96" modified="2009-03-03" version="1">MYWPTSRNERWFCWTVFAQAVAVLALEIYNLAQWESWIRPNGTQVPISYLIPINLSLIMFAVFYESLLSLKLVHDKSNILLLAICISKACVFAYSVMQYLSMEQNTHSIQTNQDMFGEPLVDLSRDLWKEIKPAEMLVPIVIGIATVIVCPVAYRLHKEYSWAIYQCVQGDPKIRFRYRGYEIYLVLIIFNVYFFIGFIVQYNLVDVHFIEPEFSLTMALIPAAVMLMVLSAYFVRYENKIGTIIVITCYLGLIAYIISRIILLCNPTGRGNTPGKDMMLLFAFLALIFTFLAMVCAIYCIVNFEHGLQTVFNRKSQIPRRSFVFQELPSRYNSARDSSRMSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRX6</accession>
    <name>B8MRX6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcriptional activator HAP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_057980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487420.1">
        <property type="nucleotide sequence ID" value="XM_002487375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRX6"/>
    <dbReference type="FunCoup" id="B8MRX6">
        <property type="interactions" value="1077"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MRX6"/>
    <dbReference type="GeneID" id="8108934"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_057980"/>
    <dbReference type="eggNOG" id="KOG1561">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045001_0_0_1"/>
    <dbReference type="InParanoid" id="B8MRX6"/>
    <dbReference type="OMA" id="MGSQVQM"/>
    <dbReference type="OrthoDB" id="1097733at2759"/>
    <dbReference type="PhylomeDB" id="B8MRX6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="253"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="343"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED13309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="358" mass="38456" checksum="3A5E214B3B5184E8" modified="2009-03-03" version="1">MEYSPQYQQPHGQHPHAQSHMAGAYQTAQNAGSNVGNLTSPTNAQAHIPQNHQASPILPGQGHYQQSQNAPGAVHQQMNFAQPYGVTTSMQPAYGISPTQAAAMATAAASGQFYPLSQDQMAGQIAQGPRGSPRMAGVQVKNERGPRSPTQVSGQIPPMPQVQMSQNAQMQQNRRMSHVGSPHLPNTQPVLNHVGRPGVPPTMPPPQTQVQQAPAGGEAVAGGTQEESPLYVNAKQFHRILKRRVARQKLEEQLRLTSKGRKPYLHESRHNHAMRRPRGPGGRFLTADEVAAMDKEKGGQEGGDQAPKPAGESNSTAQKRKSGVADDNNAHPSKKNKQNTSAEESEDVESGEPTDEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRZ6</accession>
    <name>B8MRZ6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_059200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487543.1">
        <property type="nucleotide sequence ID" value="XM_002487498.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487544.1">
        <property type="nucleotide sequence ID" value="XM_002487499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRZ6"/>
    <dbReference type="STRING" id="441959.B8MRZ6"/>
    <dbReference type="GeneID" id="8107390"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_059200"/>
    <dbReference type="eggNOG" id="KOG1200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="InParanoid" id="B8MRZ6"/>
    <dbReference type="OMA" id="FCDPLTM"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000398">
        <property type="entry name" value="Probable 2-deoxy-D-gluconate 3-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF5">
        <property type="entry name" value="2-DEHYDRO-3-DEOXY-D-GLUCONATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED13432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="268" mass="28516" checksum="A219E43F8EBB5066" modified="2009-03-03" version="1">MPIPHLFSLENRTALVTGGTRGIGAQMAIALAEVGADIILVQRDTSNQQTKQIIESLGRKSFIYTADLASREDVSGLTKKVLADGHDISILVTCAGIQRRHPAEKFPDSDWDEVLQVNLTTVFTLCRDIGAYMLTRPPFPGTESSSPGGGYRGSIINVASLVSFQGGITVPAYASAKGGIAQLTKALSNEWASKGVNVNAIAPGYVATDMNEALINNPQRAEQILVRIPAGRWGTPEDFKGPTVFLAGKASLYVSGEILTVDGGWMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSB0</accession>
    <name>B8MSB0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_000400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED11963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487617.1">
        <property type="nucleotide sequence ID" value="XM_002487572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSB0"/>
    <dbReference type="STRING" id="441959.B8MSB0"/>
    <dbReference type="GeneID" id="8108663"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_000400"/>
    <dbReference type="HOGENOM" id="CLU_963712_0_0_1"/>
    <dbReference type="InParanoid" id="B8MSB0"/>
    <dbReference type="OrthoDB" id="3562449at2759"/>
    <dbReference type="PhylomeDB" id="B8MSB0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002875344" description="PiggyBac transposable element-derived protein domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="3">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="3">
        <location>
            <begin position="123"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED11963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="289" mass="33640" checksum="445F4088EBA6939D" modified="2009-03-03" version="1">MTPSEIKIFLAILIYMGVHISPRDEDYWQTTEPLHIPRRFMGLQRFQQIKRFFHVADPRPEAAIQEAIRLIKPNQMSWYKLELFASRLRAACLQYWKPSNAVSIDETMANQAGHHKSLVKVKKHENLTLTRSTVVQLAQEGLSSQCNNYTIYMDNYFSAIPLFDHLRQLGIGACGTTRPNASKKLFPKALRVLKEPKKLQYDWVPRLRKRPAKSFTSAKNAREPFGDQLLRSFQYHGLLMTITIIWVMWIEQINYERAMKLMRDLCAHGGLYSFGPLMWLLSMPIALQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MU94</accession>
    <name>B8MU94_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_107890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488354.1">
        <property type="nucleotide sequence ID" value="XM_002488309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MU94"/>
    <dbReference type="STRING" id="441959.B8MU94"/>
    <dbReference type="GeneID" id="8106837"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_107890"/>
    <dbReference type="HOGENOM" id="CLU_013929_14_2_1"/>
    <dbReference type="InParanoid" id="B8MU94"/>
    <dbReference type="OrthoDB" id="4230168at2759"/>
    <dbReference type="PhylomeDB" id="B8MU94"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="85"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="440" mass="51115" checksum="464ABC60588BF55B" modified="2009-03-03" version="1">MWTYDFQDRLPEKYERTASEHYGEIERWFINLKIAIQDYKIRPQNLWNFDETGFIVGRGKDEAVITAYPKTSKRVSSLSSRESITVVECINAKGKIIPPLLIPKGKVHMEEWYSHIKDDDWLVTPTEHRFITDEIAFEWLQHFHHFTKPPELGPPWRLLLMDNHTTHLTMQFVEYCEIFHIRPFRFPAHSTHFLQPLDGVPFQQYKHVHGRVVNKVARLAGFDFDKNDFFEELHDIRLKTFTNRTIRNGWRERGNWPINPSLILDKMPSPEEAFEAMVAEGDTLKIHGESDDTIPSSPTTKSISPPSTAAALRRYINKIEKSIDGIKNILDEASPGLSRRIKVVNQGSFTLAELSDLHRESFAKVRATAERKNKKTTKRQVKTSGALYVKDANRLIKRRHDGDLLRIHKRHVFGAEELAEEQASTELQDLSFFIDTMGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUA1</accession>
    <name>B8MUA1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Endochitinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_107970</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GPI-anchored chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods). Required to reshape the cell wall at the sites where cell wall remodeling and/or cell wall maturation actively take place such as sites of conidia formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488362.1">
        <property type="nucleotide sequence ID" value="XM_002488317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUA1"/>
    <dbReference type="FunCoup" id="B8MUA1">
        <property type="interactions" value="173"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MUA1"/>
    <dbReference type="GeneID" id="8106861"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_107970"/>
    <dbReference type="eggNOG" id="KOG4701">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007818_6_1_1"/>
    <dbReference type="InParanoid" id="B8MUA1"/>
    <dbReference type="OMA" id="IRACQNQ"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="PhylomeDB" id="B8MUA1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02877">
        <property type="entry name" value="GH18_hevamine_XipI_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045321">
        <property type="entry name" value="Cts1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877691" evidence="7">
        <location>
            <begin position="20"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="8">
        <location>
            <begin position="31"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED11606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="340" mass="36167" checksum="2A618F2490C04580" modified="2009-03-03" version="1">MQISTVLINFALMASSTMAASHRLQGRGPGGEVVVYWGQNAAAASENNDLSNYCTAGSGINIVVLSFLYEYGNGITIPSGVIGNDCSISTSGEGTNCDALAKQIATCQSNGVKVILSLGGAVGAYSLTSQAEAETIGQNLWDAYGKTSGGSVPRPFGATFVNGWDFDIEANSGNQYYQYMIAKLRSNFVSDSSNTYYITGAPQCPIPEPNMGEIIHAARFDYLWVQFYNNRDCSYPNTLNYADWVSYVSGTPSANAKIFIGVPASELGSTGTDSGAAYYQCPKTLASTVSSFHTSSKWGGIMMWDAAFSDTNVVDGCNYAQQAHSILTTGSPLCQSVVRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8LT52</accession>
    <name>B8LT52_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_069780</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG4 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340947.1">
        <property type="nucleotide sequence ID" value="XM_002340906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LT52"/>
    <dbReference type="FunCoup" id="B8LT52">
        <property type="interactions" value="805"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LT52"/>
    <dbReference type="GeneID" id="8107345"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_069780"/>
    <dbReference type="eggNOG" id="KOG0412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8LT52"/>
    <dbReference type="OMA" id="RASECQQ"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="PhylomeDB" id="B8LT52"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="10">
        <location>
            <begin position="189"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED23560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="827" mass="91253" checksum="B44A7EED5F0B1E55" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTG7</accession>
    <name>B8LTG7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TFIID and and SAGA complex TAF10 subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_065050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF10 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340432.1">
        <property type="nucleotide sequence ID" value="XM_002340391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTG7"/>
    <dbReference type="FunCoup" id="B8LTG7">
        <property type="interactions" value="441"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LTG7"/>
    <dbReference type="GeneID" id="8104232"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_065050"/>
    <dbReference type="eggNOG" id="KOG3423">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064104_0_1_1"/>
    <dbReference type="InParanoid" id="B8LTG7"/>
    <dbReference type="OMA" id="QNGSQEH"/>
    <dbReference type="OrthoDB" id="154356at2759"/>
    <dbReference type="PhylomeDB" id="B8LTG7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED23045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="280" mass="27804" checksum="8E923FB6A260E93E" modified="2009-03-03" version="1">MADSSTNTSQSAAGSQLPPSSTQPTTQSTEALPSSSETVTASTQQGAGDATTGNRDIDLGGGDPLDNDIDNDIDMNNTDDMPTTTVNGTNDAAASAANALASAAAAPPIKKESSLREFLGKMDEYAPIIPDAVTAHYLTVAGLPPPGNGPNQTPPHLARLLALATQKFVADIAADAYQYSRIRASNSSTANNPMGGLNAAAGLNAPNAAGGAGGAGAAGAGGDAGKKSAAANTHLGIQRPGFGGGGQGGSGQGRTVLTMEDLGMAVSEYGVSIKRGEFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTI9</accession>
    <name>B8LTI9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Asparaginase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_065250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340454.1">
        <property type="nucleotide sequence ID" value="XM_002340413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTI9"/>
    <dbReference type="STRING" id="441959.B8LTI9"/>
    <dbReference type="MEROPS" id="T02.004"/>
    <dbReference type="GeneID" id="8105378"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_065250"/>
    <dbReference type="eggNOG" id="KOG1592">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8LTI9"/>
    <dbReference type="OrthoDB" id="77601at2759"/>
    <dbReference type="PhylomeDB" id="B8LTI9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04514">
        <property type="entry name" value="Taspase1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.30:FF:000007">
        <property type="entry name" value="Similar to threonine aspartase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037464">
        <property type="entry name" value="Taspase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF8">
        <property type="entry name" value="THREONINE ASPARTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="438"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="2">
        <location>
            <begin position="280"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED23067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="471" mass="50034" checksum="3A264E938F37F191" modified="2009-03-03" version="1">MSPRSRDAGDICAIYVHAGAGFHSYQNERVHLRTCNDAAKVAMTMLKNGGSALDAVEIALRLMEDREITNAGYGSNLTIEGNVECDATIMDHLGRSGAVGACSHVKNPISAARVILDSQKKPLSLQRVPPNFLVGKGATEFAYMQGLSIVENDTLVSPTAKARWLRWQQEVESARLAQEAQTATQAGGEVLHMEASSSSATFSTTVNPAVLMSPPSSLPETVSSKELDTTVVLDIVSPEPTIVPTDGTHHIRESIEEHSGDATSTDEHEPPVDNVDTITDTIGAIAVDCYGRIAAGSSSGGIGMKHSGRVGPAALVGIGTAVIPEDPQDPEQTSVAAVTSGTGEHIATTLAANTCASRIYYSDRRNEAGMTEIVTEEEAIKSMVDVDFMEHPSVKNSLCEAAIGVMAVKKTIHGVYLFFCHNTDSFALASMTSEDKAPHCVMSRRSRHGTTAQGGRFSRYRGSKSRSSADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTN6</accession>
    <name>B8LTN6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Nuclear pore complex subunit Nup133, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_070410</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341015.1">
        <property type="nucleotide sequence ID" value="XM_002340974.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B8LTN6">
        <property type="interactions" value="120"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LTN6"/>
    <dbReference type="GeneID" id="8102650"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_070410"/>
    <dbReference type="eggNOG" id="KOG4121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002493_0_0_1"/>
    <dbReference type="InParanoid" id="B8LTN6"/>
    <dbReference type="OMA" id="HANISWI"/>
    <dbReference type="OrthoDB" id="103454at2759"/>
    <dbReference type="PhylomeDB" id="B8LTN6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="10">
        <location>
            <begin position="106"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="9">
        <location>
            <begin position="644"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED23628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1326" mass="149781" checksum="B6887580DB59D6E8" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B8LU06</accession>
    <name>B8LU06_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_072290</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341223.1">
        <property type="nucleotide sequence ID" value="XM_002341182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LU06"/>
    <dbReference type="STRING" id="441959.B8LU06"/>
    <dbReference type="GeneID" id="8104267"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_072290"/>
    <dbReference type="eggNOG" id="KOG0585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004329_1_1_1"/>
    <dbReference type="InParanoid" id="B8LU06"/>
    <dbReference type="OMA" id="QAPKETH"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="PhylomeDB" id="B8LU06"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000614">
        <property type="entry name" value="Serine/threonine protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000206">
        <property type="entry name" value="Serine/threonine-protein kinase Ssp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF152">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="287"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="476"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="794"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="834"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1039"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1088"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1213"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="805"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="848"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="874"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="893"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1045"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1088"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1131"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1151"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1217"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED23836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1244" mass="137833" checksum="511A0F83DF8CDC3D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8LU20</accession>
    <name>B8LU20_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="9">Aconitase</shortName>
            <ecNumber evidence="9">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_072430</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341237.1">
        <property type="nucleotide sequence ID" value="XM_002341196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LU20"/>
    <dbReference type="FunCoup" id="B8LU20">
        <property type="interactions" value="271"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LU20"/>
    <dbReference type="GeneID" id="8109448"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_072430"/>
    <dbReference type="eggNOG" id="KOG0453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006714_2_2_1"/>
    <dbReference type="InParanoid" id="B8LU20"/>
    <dbReference type="OMA" id="KWPETFG"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="PhylomeDB" id="B8LU20"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
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        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
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    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF2">
        <property type="entry name" value="HOMOCITRATE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
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    </dbReference>
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        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="10">
        <location>
            <begin position="87"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="11">
        <location>
            <begin position="594"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED23850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="794" mass="84788" checksum="0038FD4FED4B3964" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUA2</accession>
    <name>B8LUA2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_060660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002339961.1">
        <property type="nucleotide sequence ID" value="XM_002339920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUA2"/>
    <dbReference type="STRING" id="441959.B8LUA2"/>
    <dbReference type="GeneID" id="8108647"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_060660"/>
    <dbReference type="eggNOG" id="ENOG502RUBD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_547004_0_0_1"/>
    <dbReference type="InParanoid" id="B8LUA2"/>
    <dbReference type="OrthoDB" id="5149081at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052925">
        <property type="entry name" value="Phage_Integrase-like_Recomb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605:SF3">
        <property type="entry name" value="P CELL-TYPE AGGLUTINATION PROTEIN MAP4-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED22574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="55906" checksum="2E2F8C80163187AA" modified="2009-03-03" version="1" fragment="single">MSNPAGTFDKVYHTVTDYLGIPRNNRKDEQGTCIIVLGIQIDSIAMEARLPQEKLCRATLDAAAALNATSLSLKQIESLTGLLAFCSRVVQLGRTRLQSLYTFQIAFPRGSCTRRRIPYESTLDCWWTHCHQLQSCNAASLALAQDAHVHINTTEVDAILQGFLLFSHHWLHHTLVIHTDSSTVHTGLSKGFLRGPPNVPLKSLLILAVARDIQIHNYERHYALQNLPAWPASKQSLILWLTSRLLGNSNQKAIKPDTALSDLAALQAYHIDNFLDDKLFDNKHFRRLIDRARRLTPTTKVRVRKPISCEAITKLSSGLIALPSQPSEMTADLIDDLNFATACQVTFAGFLRIGEFTYKKEDLNASSIFTSTKLTRLDIRFSPTLDHVQLTLKGSKTDRCHEGVQIILAKTGDGACPVDALQKLFFLDPRGLNAPLFSFHRRPFTHAAQHAHNSGILDDQIQALGRWTSEAFRVYFTTNALILYKLNHQFQTGSPAPLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUV9</accession>
    <name>B8LUV9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAM192A/Fyv6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_074310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341438.1">
        <property type="nucleotide sequence ID" value="XM_002341397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUV9"/>
    <dbReference type="STRING" id="441959.B8LUV9"/>
    <dbReference type="GeneID" id="8108497"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_074310"/>
    <dbReference type="eggNOG" id="KOG4036">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067596_0_1_1"/>
    <dbReference type="InParanoid" id="B8LUV9"/>
    <dbReference type="OMA" id="RYKLHVA"/>
    <dbReference type="OrthoDB" id="75807at2759"/>
    <dbReference type="PhylomeDB" id="B8LUV9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039845">
        <property type="entry name" value="FAM192A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019331">
        <property type="entry name" value="FAM192A/Fyv6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495">
        <property type="entry name" value="NEFA-INTERACTING NUCLEAR PROTEIN NIP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495:SF0">
        <property type="entry name" value="PSME3-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10187">
        <property type="entry name" value="FAM192A_Fyv6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM192A/Fyv6 N-terminal" evidence="4">
        <location>
            <begin position="23"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED24051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="268" mass="29710" checksum="CC71C9F34C18B2D4" modified="2009-03-03" version="1">MQASGVPSSSLNIERAPFMSSGFVSGGTIDEPNERDDEWRRTQQELEEERRRKAELGKQNDGKSLYEILQQNKMAKQEAFEESIRLKNQFRALDEDEVEFLDSLLESTRAQEAAVKKETAEQLAEYQRQREEAERALIEAGGQNSSGSATKPTGDEEQWVVAGRKRKRNRKDFLVPPKIRKSSFTADDASTVSDQKEKPATTIYKDVAKDSTPSASSKSAPKRIETVSDESPKGRATNTASSKDSTQHKVATGPSLGLVAYDSDEDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8LV24</accession>
    <name>B8LV24_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_061350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340032.1">
        <property type="nucleotide sequence ID" value="XM_002339991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LV24"/>
    <dbReference type="STRING" id="441959.B8LV24"/>
    <dbReference type="GeneID" id="8101081"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_061350"/>
    <dbReference type="HOGENOM" id="CLU_1138644_0_0_1"/>
    <dbReference type="InParanoid" id="B8LV24"/>
    <dbReference type="OrthoDB" id="4464205at2759"/>
    <dbReference type="PhylomeDB" id="B8LV24"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="123"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="244" mass="28078" checksum="AC651A3856F1AE18" modified="2009-03-03" version="1">MYLFGESEVQNYDILAIQESYINKHTDPLTTYSLALKGSFHILLQPTPKEEYKKRPRVCFYVNRGLDLATWEVQYHNRDLSTLILHTAAHGTIHIHNIYNLGVNSNEESIISALQTAMAPRAQLEQLLPPGTITYERVNAKSTIDLVWASHNLANRVVSCDTKLEWWYGADHVPISTQFDLTAIHVPPLVRKQWNATDWDLFLKLMDIYNWHPRELNDNEAINEAIHYLVETINQAAEQATPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVY1</accession>
    <name>B8LVY1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho guanyl nucleotide exchange factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_077140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341734.1">
        <property type="nucleotide sequence ID" value="XM_002341693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVY1"/>
    <dbReference type="STRING" id="441959.B8LVY1"/>
    <dbReference type="GeneID" id="8101059"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_077140"/>
    <dbReference type="eggNOG" id="KOG3519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007879_1_0_1"/>
    <dbReference type="InParanoid" id="B8LVY1"/>
    <dbReference type="OMA" id="QPIYPRQ"/>
    <dbReference type="OrthoDB" id="1594986at2759"/>
    <dbReference type="PhylomeDB" id="B8LVY1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00014">
        <property type="entry name" value="CH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13246">
        <property type="entry name" value="PH_Scd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000364">
        <property type="entry name" value="Rho guanyl nucleotide exchange factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000176">
        <property type="entry name" value="Rho guanyl nucleotide exchange factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010481">
        <property type="entry name" value="Cdc24/Scd1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033511">
        <property type="entry name" value="Cdc24/Scd1_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053026">
        <property type="entry name" value="CDC42_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06395">
        <property type="entry name" value="CDC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="181"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="3">
        <location>
            <begin position="812"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="781"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="684"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED24347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="910" mass="102438" checksum="A3D403BEAD77DE07" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8LW85</accession>
    <name>B8LW85_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteasome regulatory particle subunit (Nas6), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_074910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341500.1">
        <property type="nucleotide sequence ID" value="XM_002341459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LW85"/>
    <dbReference type="FunCoup" id="B8LW85">
        <property type="interactions" value="173"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LW85"/>
    <dbReference type="GeneID" id="8106217"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_074910"/>
    <dbReference type="eggNOG" id="KOG4412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_18_2_1"/>
    <dbReference type="InParanoid" id="B8LW85"/>
    <dbReference type="OMA" id="WAVAYNR"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="PhylomeDB" id="B8LW85"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904855">
        <property type="term" value="F:proteasome regulatory particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF11">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="74"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="177"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED24113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="239" mass="25604" checksum="0AA3DCFEC5449D90" modified="2009-03-03" version="1">MAAEPEAKFAIHEAAREGKTSVVESLLNANPKLASLKDDDERLPIHWAAAYNRLPIVELLVTNKYFDPDVTDGSGWTPLMIAASLKNAEGDAIIELLLRKDADVNMKSVSGQNALHFAASKANLSTVKTLVAHKCSARVKDKRGQLALHRAAAVGSTPILKILLEEGKSPVNATDVDGLTALHHAISEGHGDAAILLMKAGTDLEKRDADGNLAIDLAPDAKVRKYILQTAEREGIELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWY3</accession>
    <name>B8LWY3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetylxylan esterase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_079710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002342003.1">
        <property type="nucleotide sequence ID" value="XM_002341962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWY3"/>
    <dbReference type="STRING" id="441959.B8LWY3"/>
    <dbReference type="ESTHER" id="talsn-b8lwy3">
        <property type="family name" value="Acetylxylan_esterase"/>
    </dbReference>
    <dbReference type="GeneID" id="8103919"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_079710"/>
    <dbReference type="eggNOG" id="ENOG502RM1G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040058_4_2_1"/>
    <dbReference type="InParanoid" id="B8LWY3"/>
    <dbReference type="OMA" id="NEWSGHT"/>
    <dbReference type="OrthoDB" id="2586582at2759"/>
    <dbReference type="PhylomeDB" id="B8LWY3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630:SF9">
        <property type="entry name" value="CUTINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="CUTINASE RV1984C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877413" evidence="3">
        <location>
            <begin position="23"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED24616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="232" mass="24677" checksum="A774514E99CD6705" modified="2009-03-03" version="1">MTVSSLAFRLLILATFIVPSIAQAINPADCASSVHLLLLRGEGTGDDLNVLDTIQNLVLEQIPGATSLGVPYQHGDSDKQFAAYNGSVLLQQYIAGYATTCPDSKIAVLGYSLGAVATMNAICGVSSLLITHAVEALDFKYASNVIAVVAYGDETYVPLQSWNVGNCTIGAGIYPRLDPGACEPFASSLKSYCDYGDYQCCSILPDDANAAHHTYFTKYNQDVVAFIQSRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXC2</accession>
    <name>B8LXC2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_066500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340590.1">
        <property type="nucleotide sequence ID" value="XM_002340549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXC2"/>
    <dbReference type="STRING" id="441959.B8LXC2"/>
    <dbReference type="GeneID" id="8108507"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_066500"/>
    <dbReference type="eggNOG" id="ENOG502QVFK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029872_1_0_1"/>
    <dbReference type="InParanoid" id="B8LXC2"/>
    <dbReference type="OrthoDB" id="3915838at2759"/>
    <dbReference type="PhylomeDB" id="B8LXC2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053140">
        <property type="entry name" value="GDSL_Rv0518-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43784">
        <property type="entry name" value="GDSL-LIKE LIPASE/ACYLHYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43784:SF2">
        <property type="entry name" value="GDSL-LIKE LIPASE_ACYLHYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="172"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="384" mass="42191" checksum="5A1E657570CD0245" modified="2009-03-03" version="1">MLRQSDIAEKPRQNWVSAWYAAPQEMPSASLEGRTLRQIAFLHAEGEQIRVHLSNRYGHGSVTLSSMSVGIVIQGPIVRESRPLRFAGKATLTLSPGQEVEFTNLAVTFVTQGDCTTGHLTAQQTSYVSGRSDVSCCPSEFSWLAYPVQTSSYWLLSGVDVLPREPIKAIVAFGSSTTDGACSTLNANRLWTDYLALRLSVAGETCFMSVINASISGNTLTAIERPQDEYFAIPQFLFGEPGQVRLAWDACTHTGATDLIVNIGSNDLRLGVTADVLIEAYKQLVQLSRKSLRRIFGTTILPGGYTPEQAEQRRLVNQWLLDEGLQWLDAVFDLATPLRSLENEDILHAEFDSGDGVHPNDEGYRLMAEAIDISKLSGSEKTQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXL8</accession>
    <name>B8LXL8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">50S ribosomal protein L36, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_078740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341905.1">
        <property type="nucleotide sequence ID" value="XM_002341864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXL8"/>
    <dbReference type="STRING" id="441959.B8LXL8"/>
    <dbReference type="GeneID" id="8109430"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_078740"/>
    <dbReference type="eggNOG" id="ENOG502RZ6E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109501_1_1_1"/>
    <dbReference type="InParanoid" id="B8LXL8"/>
    <dbReference type="OMA" id="YGRGWDS"/>
    <dbReference type="OrthoDB" id="5587740at2759"/>
    <dbReference type="PhylomeDB" id="B8LXL8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034600">
        <property type="entry name" value="Ribosomal_bL31m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048874">
        <property type="entry name" value="Ribosomal_bL31m_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL31M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21492">
        <property type="entry name" value="bL31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein bL31m N-terminal" evidence="2">
        <location>
            <begin position="52"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED24518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="201" mass="21995" checksum="E6C55C63E67A6021" modified="2009-03-03" version="1">MSLNTSFRRATSGTGPSTTLSRTILKSSPTSSTSTPSTYICNQCRHASLLRRPKRPYTFTQLVALSDGSTFIHRTTSPTPVYRSTRDTRNSLLWNPTSKKLLTVEDDEAGRLAAFRAKFGRSFDLASTAAEEVAAAVGPTAAQKQTSQKSDLEQKQEAEKMDAAAEKALAQEEADLQEEEDNLLDLISSFGQQQDNTGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8LY42</accession>
    <name>B8LY42_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein arginine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_067270</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340674.1">
        <property type="nucleotide sequence ID" value="XM_002340633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LY42"/>
    <dbReference type="FunCoup" id="B8LY42">
        <property type="interactions" value="1023"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LY42"/>
    <dbReference type="GeneID" id="8107609"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_067270"/>
    <dbReference type="eggNOG" id="KOG0822">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010247_2_1_1"/>
    <dbReference type="InParanoid" id="B8LY42"/>
    <dbReference type="OMA" id="IKYAWYE"/>
    <dbReference type="OrthoDB" id="1368803at2759"/>
    <dbReference type="PhylomeDB" id="B8LY42"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071521">
        <property type="term" value="C:Cdc42 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990463">
        <property type="term" value="C:lateral cortical node"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071470">
        <property type="term" value="P:cellular response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061246">
        <property type="term" value="P:establishment or maintenance of bipolar cell polarity regulating cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903359">
        <property type="term" value="P:lateral cortical node assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903360">
        <property type="term" value="P:protein localization to lateral cortical node"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000100">
        <property type="term" value="P:regulation of establishment or maintenance of bipolar cell polarity regulating cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000149">
        <property type="entry name" value="Protein arginine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007857">
        <property type="entry name" value="Arg_MeTrfase_PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035075">
        <property type="entry name" value="PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035248">
        <property type="entry name" value="PRMT5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035247">
        <property type="entry name" value="PRMT5_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738:SF0">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05185">
        <property type="entry name" value="PRMT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17286">
        <property type="entry name" value="PRMT5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17285">
        <property type="entry name" value="PRMT5_TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015894">
        <property type="entry name" value="Skb1_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRMT5 TIM barrel" evidence="11">
        <location>
            <begin position="39"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 arginine-N-methyltransferase" evidence="10">
        <location>
            <begin position="375"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 oligomerisation" evidence="12">
        <location>
            <begin position="566"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="613"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="782"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="620"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="782"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="533"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="542"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="410"/>
            <end position="411"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="499"/>
            <end position="500"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for specifying symmetric addition of methyl groups" evidence="7">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR015894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED23287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="841" mass="92707" checksum="A69F66C48774D1AF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8LY61</accession>
    <name>B8LY61_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS phospholipid transporter (Git1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_067430</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340693.1">
        <property type="nucleotide sequence ID" value="XM_002340652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LY61"/>
    <dbReference type="STRING" id="441959.B8LY61"/>
    <dbReference type="GeneID" id="8103965"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_067430"/>
    <dbReference type="eggNOG" id="KOG0252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_46_12_1"/>
    <dbReference type="InParanoid" id="B8LY61"/>
    <dbReference type="OMA" id="IMFTNFQ"/>
    <dbReference type="OrthoDB" id="2261376at2759"/>
    <dbReference type="PhylomeDB" id="B8LY61"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="43"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED23306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="489" mass="53415" checksum="C86DC4997F7F088B" modified="2009-03-03" version="1">MSDSVEKAVMAQQPVDEKNPVNPHDAEVPLDALPKSRWERSWPVIACGAGLFSDGYLNGIIGSVNTMLGKIYPDTYNNSPASRNVSSIAFVGTVVGQLAFGITSDYWSRKWSLFIATIILIVFSALSAGAYGAGGSQEGLFAALTAYRFFLGIGIGGEYPAGSVAASESTGELKSGHRNRWFVFFTDFMIDSGYVVAAIVATVVVVITTESHLRVAWRICLGLGIVPPLSLLWLRYKLNEPEEFNRERMHKYPYGLIIKFYWKRLLVVSLIWFTYDFSSFSFSIYSTKWLDIIIGDSAPLWQSFAWSILTNTFYLPGSIAGAYLADWVGPKQTLAWGVFAQGVVGFIMTAAYKQLGTPEYVAAFVVVFGIFSALGELGPGDNIGLIASKSSATAIRGQYYGVAAAMGKIGAFVGTYVLPIAQNHAPNKVRAGQDPFIISSSLCIFSAVICWLFVPHIGQDTISEEDQRFREYLEAHGYDTSTMGSKPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYB8</accession>
    <name>B8LYB8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin MVP1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Sorting nexin mvp1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_063290</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for vacuolar protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340235.1">
        <property type="nucleotide sequence ID" value="XM_002340194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYB8"/>
    <dbReference type="FunCoup" id="B8LYB8">
        <property type="interactions" value="163"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LYB8"/>
    <dbReference type="GeneID" id="8104688"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_063290"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009058_1_0_1"/>
    <dbReference type="InParanoid" id="B8LYB8"/>
    <dbReference type="OrthoDB" id="10064318at2759"/>
    <dbReference type="PhylomeDB" id="B8LYB8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07597">
        <property type="entry name" value="BAR_SNX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06866">
        <property type="entry name" value="PX_SNX8_Mvp1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000037">
        <property type="entry name" value="Sorting nexin mvp-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000072">
        <property type="entry name" value="Sorting nexin MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028662">
        <property type="entry name" value="SNX8/Mvp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035704">
        <property type="entry name" value="SNX8/Mvp1_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045734">
        <property type="entry name" value="Snx8_BAR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47554">
        <property type="entry name" value="SORTING NEXIN MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47554:SF1">
        <property type="entry name" value="SORTING NEXIN MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19566">
        <property type="entry name" value="Snx8_BAR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="12">
        <location>
            <begin position="336"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="183"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="237"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED22848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="716" mass="78843" checksum="91DB63FFADE8F6C7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYR3</accession>
    <name>B8LYR3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.205</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2'-O-ribose RNA methyltransferase TRM7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_068460</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42396"/>
            <dbReference type="Rhea" id="RHEA-COMP:10246"/>
            <dbReference type="Rhea" id="RHEA-COMP:10247"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.205"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.205" evidence="7"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340808.1">
        <property type="nucleotide sequence ID" value="XM_002340767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYR3"/>
    <dbReference type="FunCoup" id="B8LYR3">
        <property type="interactions" value="914"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LYR3"/>
    <dbReference type="GeneID" id="8108652"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_068460"/>
    <dbReference type="eggNOG" id="KOG1099">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009422_1_0_1"/>
    <dbReference type="InParanoid" id="B8LYR3"/>
    <dbReference type="OMA" id="FIVCLNF"/>
    <dbReference type="OrthoDB" id="289250at2759"/>
    <dbReference type="PhylomeDB" id="B8LYR3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106340">
        <property type="term" value="F:tRNA (guanosine(34)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106050">
        <property type="term" value="F:tRNA 2'-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002130">
        <property type="term" value="P:wobble position ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03162">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028590">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF12">
        <property type="entry name" value="TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="9">
        <location>
            <begin position="21"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="9">
        <location>
            <begin position="121"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED23421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="425" mass="47060" checksum="2DF4DD5FEDB98F17" modified="2009-03-03" version="1">MGKASKDKRDAYYRLAKEQNWRARSAFKLIQIDEQFDLFAHADPDSVTRVVDLCAAPGSWSQVLSRVLIKGESFGRRAWLEKRRRDKKALEKVGKESENTQEGEQDDDDTEDESIILKPRKNVKIVAIDLQPMAPLEGITMMKADITHPSTIPLLLRALDPEYYEEGSEKRDTPQSNTTTSTKLPSRHPHPVDLVISDGAPDVTGLHDLDIYIQSQLLYAALNLTIGVLRPGGKFVAKIFRGRDVDLLYAQLRTVFEKVSVAKPRSSRASSLEAFVVCEGFMPPEDFDSTHALQNPMFGGAAVSKETNEDGTVGYDIPDDDEKPQQSRIAQYVPATANGDALDQLTLAEQLSHPPPHESRWIPPFIACGDLSAWDADASYALPEGYVSLDPVQPPTAPPYKRALEMRKELGGTYGKTKLGATGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYZ4</accession>
    <name>B8LYZ4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_069230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340889.1">
        <property type="nucleotide sequence ID" value="XM_002340848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYZ4"/>
    <dbReference type="STRING" id="441959.B8LYZ4"/>
    <dbReference type="GeneID" id="8101056"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_069230"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_25_2_1"/>
    <dbReference type="InParanoid" id="B8LYZ4"/>
    <dbReference type="OMA" id="RNWHFLE"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="PhylomeDB" id="B8LYZ4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11070">
        <property type="entry name" value="CYP56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED23502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="572" mass="65629" checksum="2D6FA2F3C2F72BE6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZI0</accession>
    <name>B8LZI0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_093080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479025.1">
        <property type="nucleotide sequence ID" value="XM_002478980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZI0"/>
    <dbReference type="GeneID" id="8102552"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_093080"/>
    <dbReference type="HOGENOM" id="CLU_083054_0_1_1"/>
    <dbReference type="InParanoid" id="B8LZI0"/>
    <dbReference type="OrthoDB" id="2923349at2759"/>
    <dbReference type="PhylomeDB" id="B8LZI0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050135">
        <property type="term" value="F:NADP+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053024">
        <property type="entry name" value="Fungal_surface_NADase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025331">
        <property type="entry name" value="TNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42059">
        <property type="entry name" value="TNT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42059:SF1">
        <property type="entry name" value="TNT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14021">
        <property type="entry name" value="TNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877459" description="TNT domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="TNT" evidence="2">
        <location>
            <begin position="124"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED22062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="187" mass="20432" checksum="0861679E4180FC3E" modified="2009-03-03" version="1">MIFTLATHLTLFVRLALSQIENPITMPSPTTTLDVTMLNANSQQTPSSHYAVSTALCGDQRLGPTALPSHTLINSMLVNYHPSGMECPQGYRDAWINYTGIATSPPLHGFKMFPNGTQIMSRVTIPNNIYIVRFGDPNCTYVSPAGTPYEHRAIPPSNLVRRSANGTVYGRILTLTEIEVENGTIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZP5</accession>
    <name>B8LZP5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glucose dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_097170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479431.1">
        <property type="nucleotide sequence ID" value="XM_002479386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZP5"/>
    <dbReference type="STRING" id="441959.B8LZP5"/>
    <dbReference type="GeneID" id="8109498"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_097170"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_3_1"/>
    <dbReference type="InParanoid" id="B8LZP5"/>
    <dbReference type="OMA" id="ATGWDWE"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="PhylomeDB" id="B8LZP5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF123">
        <property type="entry name" value="GMC OXIDOREDUCTASE (AFU_ORTHOLOGUE AFUA_2G01770)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="496"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="534"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED22468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="557" mass="60558" checksum="A033AFA94216F41A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B8M011</accession>
    <name>B8M011_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_081760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477906.1">
        <property type="nucleotide sequence ID" value="XM_002477861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M011"/>
    <dbReference type="GeneID" id="8104814"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_081760"/>
    <dbReference type="HOGENOM" id="CLU_1644854_0_0_1"/>
    <dbReference type="InParanoid" id="B8M011"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="161" mass="18348" checksum="05A6A4D001FEBE2F" modified="2009-03-03" version="1">MAMTSHNQSPSDMFVELDSEWMQKLFEGQADARCFNEIHEVFQQPLAQCTGSGWGTGEIRAGLSEPPDDATITEQDEVVDQSLVIQALTERVASLESQVRTQLGVMMAMLHENTEETDAWCQKILEAIKVLSQRKEQPPDTDPRRRHGPRTRRETRLSHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1A5</accession>
    <name>B8M1A5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FAD dependent oxidoreductase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_082800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478010.1">
        <property type="nucleotide sequence ID" value="XM_002477965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1A5"/>
    <dbReference type="STRING" id="441959.B8M1A5"/>
    <dbReference type="GeneID" id="8105158"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_082800"/>
    <dbReference type="eggNOG" id="KOG3923">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034311_3_0_1"/>
    <dbReference type="InParanoid" id="B8M1A5"/>
    <dbReference type="OMA" id="TDPTRHM"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="PhylomeDB" id="B8M1A5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF29">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_6G10230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="8">
        <location>
            <begin position="30"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED21047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="366" mass="39814" checksum="BD06492B53159397" modified="2009-03-03" version="1">MAVKPVMPTEGTATTLNESSETTPFAQRPIIILGAGIIGCAAAYQLLQNGFQVTLVGEYLPGDKSILYASAWAGAAWHAAAGLDGDQKYIQAVTHRYLLKMALDDPSSGVCMVKGKEYVEQAPGKNSSAWGKTVLNNFHTLKPGEYPSNFATAWEYDCLVVDPTLHMPWIGAKVEALGGRFVRQRVSSLGDLYNMYPESSIFINASGWGSRDLTDVLDPKCFPDRGQNVLLKSTKSDTMYFRNGKEYTYIIPRPLSGHLILGGHNSRDNLSGEPDLDVARDEIRRAHILAPDLVPAEPAETDVSYIIGIRPARDGGFRLDSQNIGNRIVLSAYGFAGGGYAFSYGIGDALVKMVQQAEFDNVILPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8M212</accession>
    <name>B8M212_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_086210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478353.1">
        <property type="nucleotide sequence ID" value="XM_002478308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M212"/>
    <dbReference type="GeneID" id="8104586"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_086210"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1235759_0_0_1"/>
    <dbReference type="InParanoid" id="B8M212"/>
    <dbReference type="OMA" id="GANTEGM"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="PhylomeDB" id="B8M212"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
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        <source>
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        </source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED21390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="224" mass="24153" checksum="AD3EBA0EB1602375" modified="2009-03-03" version="1">MDALIMGCVICGLGGAGMYFGSMALLTQMTSERERPLFLNLVGNLVVGGVCAPVYLFLLPVLNPHPGQTIKRRAGEIDYIGVVLPCGLILSIGMAISFGGVEYAWNSGRIIALFVIAFVLLSAFLAQQILSIGTSVDNHKFPVPFLMSSCSLIVLFLEIACAATCVLVPVYFLHLYFQFVRANSAILAAILMLPFMAFHTAIAILSGWLVAEPVTMFHGTYLRA</sequence>
</entry>
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    <accession>B8M239</accession>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
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        <subcellularLocation>
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    <dbReference type="GeneID" id="8100868"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_087390"/>
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    <dbReference type="OrthoDB" id="2269373at2759"/>
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    <dbReference type="Proteomes" id="UP000001745">
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
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        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        </location>
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        </location>
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            <end position="171"/>
        </location>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50048"/>
        </source>
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        </source>
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        </source>
    </evidence>
    <sequence length="764" mass="86756" checksum="A6906574FA63CD16" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2B4</accession>
    <name>B8M2B4_TALSN</name>
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        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
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        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
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        </lineage>
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002478496.1"/>
    </dbReference>
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    <dbReference type="STRING" id="441959.B8M2B4"/>
    <dbReference type="GeneID" id="8106911"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_088140"/>
    <dbReference type="eggNOG" id="ENOG502S4S5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_597412_0_0_1"/>
    <dbReference type="InParanoid" id="B8M2B4"/>
    <dbReference type="OMA" id="MWSILAT"/>
    <dbReference type="OrthoDB" id="2943660at2759"/>
    <dbReference type="PhylomeDB" id="B8M2B4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TF_fung"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF10">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
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        </location>
    </feature>
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        <location>
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        <location>
            <begin position="8"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED21578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="458" mass="51936" checksum="5530FF2B91628543" modified="2009-03-03" version="1">MFDAVEFLPSVNSDSPTSSPTSSVLPSQSQLLELTRIFFQQHHPLLPCIHAQAILDRISDPQWAESSPLMWSILATVARSSEAIEILAQRKMWYERAMFLYERSVVSNGDVLRNVQAAVWNVYLQFMEGDILQASLRLAQAYTLACMHGFNRIDDDRKPTHVKIPLAHAMEEEECRWTMWAFFLLDRHINYLHGVHFVVNDHMFYVNYPCNNLANSPSIEIADAELFSRDLELWSLTLPPGKSSGMPITRLFQKAVVLLGRIVEYENIVPIDADQKQRAAEYLKLQSTLVQFWIPVSTHLSNAFHDPYVTWLNIILHTCSILLNYPVSVCGKTDGLPSKFAQGSANHQGFLRAFRGVQAIVDLLKQLLTANQSLSTLLNPLLAPSYFLCCRFLVARWRQTHDESYRIQWGLVVDLLGRMADKGFHLARLFKDTVARDVQTGGPAGPLVHLGLEDGMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2W4</accession>
    <name>B8M2W4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_094650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479182.1">
        <property type="nucleotide sequence ID" value="XM_002479137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2W4"/>
    <dbReference type="STRING" id="441959.B8M2W4"/>
    <dbReference type="GeneID" id="8103795"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_094650"/>
    <dbReference type="eggNOG" id="ENOG502SSIK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_716063_0_0_1"/>
    <dbReference type="InParanoid" id="B8M2W4"/>
    <dbReference type="OrthoDB" id="5404335at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="386" mass="44369" checksum="83AD97EB2F374B64" modified="2009-03-03" version="1">MSNSMQTASDRTFLAAAILAAGAFVISLLQLVLQYISSSETQNKCNRAAINFSEKDVTHKWSFRSWKLKVYYPELDMSCFRILEAMQDAWEYGIDYSNIKDFAYEQGMWWHILHADDEPGWRNISDELTALAKDSDQGNYKNYSLIKDSELRWRKRLRFWWWRYRHPLKLMRRPRASWSQIITAFGIRNTKLLKRRVIDADTIPASMDVPFQYVELSQLGRLCVVMGFKDIIIDPVDRNFYATGPSRTITTQEIPTFGKVLRFDGDTFAINYTVVRANSVEWMGTMANISCGAMFFGRYMCGHLVHLPIDLLAEAIGLDSSISKFDEDIKKFIESDEDVEDGFAGNLLKEAHNFQDLMTGLQKSQNCGDLSPEYPVRPSALIIIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8M319</accession>
    <name>B8M319_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sister chromatid separation protein (Src1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_092370</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478958.1">
        <property type="nucleotide sequence ID" value="XM_002478913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M319"/>
    <dbReference type="FunCoup" id="B8M319">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M319"/>
    <dbReference type="GeneID" id="8099419"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_092370"/>
    <dbReference type="eggNOG" id="ENOG502QVG5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010838_2_0_1"/>
    <dbReference type="InParanoid" id="B8M319"/>
    <dbReference type="OMA" id="KWECGEL"/>
    <dbReference type="OrthoDB" id="2503928at2759"/>
    <dbReference type="PhylomeDB" id="B8M319"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12935">
        <property type="entry name" value="LEM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1180">
        <property type="entry name" value="MAN1, winged-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025856">
        <property type="entry name" value="HeH/LEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044780">
        <property type="entry name" value="Heh2/Src1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018996">
        <property type="entry name" value="Man1/Src1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041885">
        <property type="entry name" value="MAN1_winged_helix_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN HEH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808:SF2">
        <property type="entry name" value="LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12949">
        <property type="entry name" value="HeH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09402">
        <property type="entry name" value="MSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="542"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="HeH/LEM" evidence="10">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Man1/Src1-like C-terminal" evidence="9">
        <location>
            <begin position="338"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="72"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="673"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="699"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED21995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="713" mass="79583" checksum="74AAE467D551407A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8M382</accession>
    <name>B8M382_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GPI anchor transamidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_095000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479217.1">
        <property type="nucleotide sequence ID" value="XM_002479172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M382"/>
    <dbReference type="FunCoup" id="B8M382">
        <property type="interactions" value="676"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M382"/>
    <dbReference type="MEROPS" id="C13.005"/>
    <dbReference type="GeneID" id="8103830"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_095000"/>
    <dbReference type="eggNOG" id="KOG1349">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044656_2_2_1"/>
    <dbReference type="InParanoid" id="B8M382"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="PhylomeDB" id="B8M382"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000003">
        <property type="entry name" value="GPI-anchor transamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500138">
        <property type="entry name" value="GPI8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED22254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="424" mass="47288" checksum="3B77EE5174C37E32" modified="2009-03-03" version="1">MSSEIGIVDSPSDPPGRFSTSVRAGLATLLLSCTIPVSVFGEHTSNWAVLVSTSRFWFNYRHLANVLSLYRTVKRLGIPDSQIILMLPDDMACNPRNAFPGTVYSNADRAVDLYGENIEVDYRGYEVTVENFIRLLTDRLDEDVPRSKRLGSDAGSNVLVYMTGHGGDRFLKFQDSEEIGAWDLADAFGQMWEKKRYHELLFMIDTCQANTMYTHFYSPNIIATGSSALDESSYSHHADNDVGVAVIDRWTYYVLEFLETQVTSPNSKLTLGDLFDSYDESKIHSQPGLRWDLFPGGEQEGRLRTVVDFFGNTQAVQVESNATRGPGSLKEDLDEIAKLVEKWQRREQGYPFLQNRTIASDEKQKQSEPSSTAAAAATDRHRQVVVGASKMTDEDSWTKRLVGLAVIGAGTGLWLAGSVFGRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3D3</accession>
    <name>B8M3D3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_095540</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit APL3 and beta-type subunit APL1), a medium chain (mu-type subunit APM4) and a small adaptin (sigma-type subunit APS2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479268.1">
        <property type="nucleotide sequence ID" value="XM_002479223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3D3"/>
    <dbReference type="FunCoup" id="B8M3D3">
        <property type="interactions" value="465"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M3D3"/>
    <dbReference type="GeneID" id="8105865"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_095540"/>
    <dbReference type="eggNOG" id="KOG0935">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061221_3_2_1"/>
    <dbReference type="InParanoid" id="B8M3D3"/>
    <dbReference type="OMA" id="QSNFVEY"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="PhylomeDB" id="B8M3D3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14833">
        <property type="entry name" value="AP2_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000011">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027156">
        <property type="entry name" value="APS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0168">Coated pit</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="3"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED22305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="145" mass="17103" checksum="2E0F281B16410B72" modified="2009-03-03" version="1">MVLSFILIQNRQGKTRLAKWYAPYSDDEKVKLKGEVHRLVAPRDQKYQSNFVEFKRSTKIVYRRYAGLFFCVCVDANDNELAYLEAIHFFVEVLDQFFGNVCELDLVFNFYKVYAILDEVFLAGEIEETSKQVVLTRLEHLDKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3X0</accession>
    <name>B8M3X0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_039160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481147.1">
        <property type="nucleotide sequence ID" value="XM_002481102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3X0"/>
    <dbReference type="STRING" id="441959.B8M3X0"/>
    <dbReference type="GeneID" id="8109254"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_039160"/>
    <dbReference type="eggNOG" id="ENOG502SEMD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099097_0_0_1"/>
    <dbReference type="InParanoid" id="B8M3X0"/>
    <dbReference type="OMA" id="CRVVMGY"/>
    <dbReference type="OrthoDB" id="418131at2759"/>
    <dbReference type="PhylomeDB" id="B8M3X0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="249" mass="27608" checksum="CC6C618A2FAD5B2D" modified="2009-03-03" version="1">MNDQHPNQANPSESHAESQPLNGTTEETENKLPIKTYHCRFCSHLLIASTRDLLSSTTPLRRRRQYIAKGGEGEGGEGGLDGALILEIPSSNTPKNKRRKVSEDHSIEESDPVERNTQSTTTAPGTNDQEAEKLNRKPEQAHYTILLSTLIPDTNPVIIRREDGVVVGYELATGNTPHSHESDGDEEDEFNRKNTTDRAIYLLPGSIVRTEDLEVGLEDTGVGGDVLNAIVEKNAVLKGMEREWMDWVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4C3</accession>
    <name>B8M4C3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Squalene synthase</fullName>
            <shortName evidence="15">SQS</shortName>
            <shortName evidence="15">SS</shortName>
            <ecNumber evidence="4 15">2.5.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSTA_024420</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 (2E,6E)-farnesyl diphosphate + NADH + H(+) = squalene + 2 diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:32299"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 (2E,6E)-farnesyl diphosphate + NADPH + H(+) = squalene + 2 diphosphate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:32295"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.21" evidence="4 15"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479552.1">
        <property type="nucleotide sequence ID" value="XM_002479507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4C3"/>
    <dbReference type="FunCoup" id="B8M4C3">
        <property type="interactions" value="320"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M4C3"/>
    <dbReference type="GeneID" id="8097973"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_024420"/>
    <dbReference type="eggNOG" id="KOG1459">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031981_2_1_1"/>
    <dbReference type="InParanoid" id="B8M4C3"/>
    <dbReference type="OMA" id="GEACQLM"/>
    <dbReference type="OrthoDB" id="431150at2759"/>
    <dbReference type="PhylomeDB" id="B8M4C3"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045338">
        <property type="term" value="P:farnesyl diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902767">
        <property type="term" value="P:isoprenoid biosynthetic process via mevalonate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000003">
        <property type="entry name" value="Farnesyl-diphosphate farnesyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006449">
        <property type="entry name" value="Squal_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044844">
        <property type="entry name" value="Trans_IPPS_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SQUALENE SYNTHASE"/>
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    </dbReference>
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        <property type="entry name" value="SQS_PSY"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Terpenoid synthases"/>
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    </dbReference>
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    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 15 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012373"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU368088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EED19118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="471" mass="54552" checksum="0ED924615DA1BB14" modified="2009-03-03" version="1">MGLLWNIAYYTFHPSELRSIVQWKVWHNPPHERDTSKDPETLKKCLYLLDLTSRSFSAVIKELHPELLVAVAVFYLVLRGLDTIEDDTSVPLDVKEPLLRDFKNIIEKDGWTWNGNRPEEKDRQVLVEFDNVIAEYKKLKPAYRAIIKDMTDKMGNGMADFVRKAETEGISVKTNEEYDLYCYYVAGLVGDGLTQLFVEAQFGNPGLLSRPNLHKSMGLFLQKTNIIRDIREDHDDQRHFWPQEIWSKHVEKFEDLFDPRCKEAALNCSSEMVLNALEHVDECLFYLAGLREQSVFNFCAIPQAMAIATLELCFRNYSMFERNIKIKKGDACRLMFESTQNLRVLCETFRTYARRIHQKNTPKDPNFVKISIACGSIEKFVETLFPSQTAEQAKLKLSGQPTEEDEKKKQHDKESWEEIKMMMVIMGSIITVITVILVGAAWFLGARFDLAWADLRKGNFRPANKIEHSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8M503</accession>
    <name>B8M503_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_028910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143030_0_0_1"/>
    <dbReference type="InParanoid" id="B8M503"/>
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    <dbReference type="PhylomeDB" id="B8M503"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED19609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="155" mass="17264" checksum="4962BDBCE2B8AFB7" modified="2009-03-03" version="1">MLVTTKALMTLPETLFFQVYPPRWGLQSSTYQTTTKAQRQYWRDKLITAAQTKEVFDISKWHKSVGLYRSPPLKDPLRPNEPPAVSTQEKRDLLVCNVLQNTAEAGDIPLDCPAAPSAALLFPEISIEQVEKAILKAGNTAPGEDELQTNILKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5P6</accession>
    <name>B8M5P6_TALSN</name>
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        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">TSTA_031990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002480329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5P6"/>
    <dbReference type="GeneID" id="8099812"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_031990"/>
    <dbReference type="eggNOG" id="ENOG502SVBM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_11_2_1"/>
    <dbReference type="InParanoid" id="B8M5P6"/>
    <dbReference type="OMA" id="GHAQDIC"/>
    <dbReference type="OrthoDB" id="4357294at2759"/>
    <dbReference type="PhylomeDB" id="B8M5P6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="596"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="974" mass="106897" checksum="D33BE20B5492D488" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5Y8</accession>
    <name>B8M5Y8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosome biogenesis protein Kri1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_033580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KRI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480549.1">
        <property type="nucleotide sequence ID" value="XM_002480504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5Y8"/>
    <dbReference type="FunCoup" id="B8M5Y8">
        <property type="interactions" value="653"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M5Y8"/>
    <dbReference type="GeneID" id="8097775"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_033580"/>
    <dbReference type="eggNOG" id="KOG2409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009647_3_0_1"/>
    <dbReference type="InParanoid" id="B8M5Y8"/>
    <dbReference type="OMA" id="WDNYDPR"/>
    <dbReference type="OrthoDB" id="10252032at2759"/>
    <dbReference type="PhylomeDB" id="B8M5Y8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018034">
        <property type="entry name" value="Kri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024626">
        <property type="entry name" value="Kri1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490:SF5">
        <property type="entry name" value="PROTEIN KRI1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490">
        <property type="entry name" value="ZINC FINGER, ZZ TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05178">
        <property type="entry name" value="Kri1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12936">
        <property type="entry name" value="Kri1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kri1-like C-terminal" evidence="3">
        <location>
            <begin position="486"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="553"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="304"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="444"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="557"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="595"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED20115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="620" mass="71819" checksum="25C910F690A44B38" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6A6</accession>
    <name>B8M6A6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">TSTA_025960</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479715.1">
        <property type="nucleotide sequence ID" value="XM_002479670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6A6"/>
    <dbReference type="FunCoup" id="B8M6A6">
        <property type="interactions" value="373"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M6A6"/>
    <dbReference type="GeneID" id="8108008"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_025960"/>
    <dbReference type="eggNOG" id="KOG0210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000846_6_0_1"/>
    <dbReference type="InParanoid" id="B8M6A6"/>
    <dbReference type="OMA" id="IAITTWH"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="PhylomeDB" id="B8M6A6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000048">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000067">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000009">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF5">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="23" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 18 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 19" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1086"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1139"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1182"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1228"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="152"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="22">
        <location>
            <begin position="1027"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="95"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="329"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="16">
        <location>
            <position position="594"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="594"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="594"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="595"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="596"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="596"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="704"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="748"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="782"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="811"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="892"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="893"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="894"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="974"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="980"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1000"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1003"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1004"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1004"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EED19281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1263" mass="140012" checksum="49A8185E18C0771E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6E5</accession>
    <name>B8M6E5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CWF21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_026310</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC21 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479754.1">
        <property type="nucleotide sequence ID" value="XM_002479709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6E5"/>
    <dbReference type="STRING" id="441959.B8M6E5"/>
    <dbReference type="GeneID" id="8098912"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_026310"/>
    <dbReference type="eggNOG" id="KOG1869">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_494466_0_0_1"/>
    <dbReference type="InParanoid" id="B8M6E5"/>
    <dbReference type="OrthoDB" id="10267305at2759"/>
    <dbReference type="PhylomeDB" id="B8M6E5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21372">
        <property type="entry name" value="cwf21_CWC21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051372">
        <property type="entry name" value="CWC21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562:SF5">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CWF21" evidence="8">
        <location>
            <begin position="397"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="365"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="451"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="507"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="414"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="507"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED19320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="551" mass="63375" checksum="13F49BC8CF571F7C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8M717</accession>
    <name>B8M717_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AMP dependent ligase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_034740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480672.1">
        <property type="nucleotide sequence ID" value="XM_002480627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M717"/>
    <dbReference type="STRING" id="441959.B8M717"/>
    <dbReference type="GeneID" id="8104316"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_034740"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_716064_0_0_1"/>
    <dbReference type="InParanoid" id="B8M717"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF3">
        <property type="entry name" value="SIDEROPHORE SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="386" mass="41043" checksum="52259F29BE96ACDB" modified="2009-03-03" version="1">MLSAGGIYRSPSTLMGLPSVRPRVTHTITSPSKLANEIGWGTELNSWVTQPENPDKLAIISALGELWLEGPLVGAGYFGEREKRAAAYIENPDWLLSVGQVILAELGACTRLATWCAIIQTVKVRGQRVELAEIEHHVRNALAFQKGGDNKILTAFVSTSVTDDNAGKSALGARVSQATETLQEQVPSYMIPGAYVFLQRMPMSATGKTGQKKLHAIGSSMTLEELTSLGNTYGEGGRRAPTTATELRLQAASACTLQTSAEKLGLDDNFLRIGGDSILAARREGLSIKVSDIFRKPTLAGLATLATEIPTTASDLPEPIAPFSILRPGISFAHIRSHAAAACGVPHDLIQDAFPCTPLQEGLMALSRHALYAVASIFQGAAKGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8M769</accession>
    <name>B8M769_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH-quinone oxidoreductase Pst2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_035180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WrbA family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480723.1">
        <property type="nucleotide sequence ID" value="XM_002480678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M769"/>
    <dbReference type="FunCoup" id="B8M769">
        <property type="interactions" value="431"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M769"/>
    <dbReference type="GeneID" id="8107468"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_035180"/>
    <dbReference type="eggNOG" id="KOG3135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051402_0_1_1"/>
    <dbReference type="InParanoid" id="B8M769"/>
    <dbReference type="OMA" id="KFADGNP"/>
    <dbReference type="OrthoDB" id="504689at2759"/>
    <dbReference type="PhylomeDB" id="B8M769"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="7"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED20289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="212" mass="22397" checksum="8D6AE5A6275FE0B2" modified="2009-03-03" version="1">MSSSPKIAIIFYSMYGHILKLAEAEKAGIEAAGGKADIYQIEETLPEDVLAKMHAPPKSSYPIATVNTLLDYNAVLFGIPTRYGNFPAQWKAFWDRTGGIWASGGYWGKYAGLFVSTGTLGGGQESTCIAAMSTLAHHGFIYVPLGYKTVFPMLSNLDEVHGGSAWGAGTFAATDGSRQPSALELQIATSQGKAFCETVSKVVVGSNVTGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8M773</accession>
    <name>B8M773_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Antigenic thaumatin domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_035210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480727.1">
        <property type="nucleotide sequence ID" value="XM_002480682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M773"/>
    <dbReference type="STRING" id="441959.B8M773"/>
    <dbReference type="GeneID" id="8107471"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_035210"/>
    <dbReference type="eggNOG" id="ENOG502SSWE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083650_2_1_1"/>
    <dbReference type="InParanoid" id="B8M773"/>
    <dbReference type="OrthoDB" id="5144514at2759"/>
    <dbReference type="PhylomeDB" id="B8M773"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195:SF6">
        <property type="entry name" value="SECRETED THAUMATIN-LIKE PROTEIN CALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002874881" description="Antigenic thaumatin domain protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="22459" checksum="A5D57346D3462EEC" modified="2009-03-03" version="1">MFSKALGLFAALSAVATALPAVHNSNNVRHHAHSQHRQLMARQEANITSDGVQIVNNMEKTVYLWSVSDVSSEMYTLNSGESYSENWRTNPNGGGVSIKISFSPEQTNVLQYEYTYQDPIIWWDLSCINMGDNSEFTTMGFAVSSADSTCEAATCAPGDIACAAAYLLPDDNWATHSCQSHDLLKLDLGSLLDQVQVDPFILEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7D3</accession>
    <name>B8M7D3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="4">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_035800</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480787.1">
        <property type="nucleotide sequence ID" value="XM_002480742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7D3"/>
    <dbReference type="FunCoup" id="B8M7D3">
        <property type="interactions" value="1008"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M7D3"/>
    <dbReference type="GeneID" id="8107529"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_035800"/>
    <dbReference type="eggNOG" id="KOG1268">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012520_5_2_1"/>
    <dbReference type="InParanoid" id="B8M7D3"/>
    <dbReference type="OMA" id="ASEYRYA"/>
    <dbReference type="OrthoDB" id="15235at2759"/>
    <dbReference type="PhylomeDB" id="B8M7D3"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00714">
        <property type="entry name" value="GFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000001">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000002">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GFAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047084">
        <property type="entry name" value="GFAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="11">
        <location>
            <begin position="2"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="371"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="543"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED20353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="694" mass="77477" checksum="EFB91C2D935B9E3E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7R4</accession>
    <name>B8M7R4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_030590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002480182.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="B8M7R4">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M7R4"/>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_030590"/>
    <dbReference type="eggNOG" id="KOG0586">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019271_2_0_1"/>
    <dbReference type="InParanoid" id="B8M7R4"/>
    <dbReference type="OMA" id="IARCEWA"/>
    <dbReference type="OrthoDB" id="410920at2759"/>
    <dbReference type="PhylomeDB" id="B8M7R4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000640">
        <property type="entry name" value="Serine/threonine-protein kinase PRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF84">
        <property type="entry name" value="TESTIS SPECIFIC SERINE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="349"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="80"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="199"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="291"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="97"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED19793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="679" mass="75102" checksum="B94C8EE35856EF44" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8M845</accession>
    <name>B8M845_TALSN</name>
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        <recommendedName>
            <fullName evidence="4">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_032610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M845"/>
    <dbReference type="STRING" id="441959.B8M845"/>
    <dbReference type="GeneID" id="8099874"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_032610"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_729935_0_0_1"/>
    <dbReference type="InParanoid" id="B8M845"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="PhylomeDB" id="B8M845"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF6">
        <property type="entry name" value="AMIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="4">
        <location>
            <begin position="97"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED20007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="379" mass="41706" checksum="6DDADB150BC1C3D2" modified="2009-03-03" version="1">MSPPIAVQEPQHVQVTGNSDTEASPRWLELCNIKQAERERSIPVAWRIPPSCLPAEKRLLDVPTTCGILTEEESKITSVFNVIELLEQIKSGRLSSEAVNCLTEVFFDETIPRARALDEGKRLHPEWPIRPLQGQDSSIGLACFVGKPATVNSILVDDLFSLGAILYCKTDLGQLMLTADSDNNVLGRTLNPTHIDMTPGALKRRGGPLRGSILGVATDMGRSVRGPCSATGVYALKPSSGIIPYDNKQIAISPGIRPIMEAEPWKRDVTCHHIPWTRRYQQPKALRIGVIMDDGCFTSTPLIHRALRESIVRFEKAGHRVISYRKAIEETENTLAKYPTQKLGGSCTLQLVGKAQNDEEFANVAVQIDSVLDPKRTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9V9</accession>
    <name>B8M9V9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FUN14 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_118770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FUN14 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482103.1">
        <property type="nucleotide sequence ID" value="XM_002482058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9V9"/>
    <dbReference type="STRING" id="441959.B8M9V9"/>
    <dbReference type="GeneID" id="8108551"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_118770"/>
    <dbReference type="eggNOG" id="ENOG502SEUQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106353_1_1_1"/>
    <dbReference type="InParanoid" id="B8M9V9"/>
    <dbReference type="OMA" id="KRPFKMS"/>
    <dbReference type="OrthoDB" id="3990500at2759"/>
    <dbReference type="PhylomeDB" id="B8M9V9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346">
        <property type="entry name" value="FUN14 DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346:SF0">
        <property type="entry name" value="RE45833P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED18111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="18861" checksum="BED6D5635EE7D41E" modified="2009-03-03" version="1">MAFFTSPLRPVLTTTCTLLGTGIGLSLLVPSSPFRSPPLQCQYTAPYYSPTASPDSGWSLAGSEAVAKQGRTSSTQPGTGLLNARFMRQVSLGSVLGLATGLGLRVFSKALVFVLGIGIVFIEWAASKGYNIVPVNTLQKYVKKFDLQRATRENVPFKVSFGATMAFAAFASFADYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9Y0</accession>
    <name>B8M9Y0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Efflux pump antibiotic resistance protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_118960</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482124.1">
        <property type="nucleotide sequence ID" value="XM_002482079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9Y0"/>
    <dbReference type="GeneID" id="8108570"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_118960"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="InParanoid" id="B8M9Y0"/>
    <dbReference type="OMA" id="KCRMIDW"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="PhylomeDB" id="B8M9Y0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000429">
        <property type="entry name" value="MFS drug efflux transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="52"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED18132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="550" mass="58921" checksum="2C581BAABB6F857A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MA05</accession>
    <name>B8MA05_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2,4-dienoyl-CoA reductase [NADPH], putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_119210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482149.1">
        <property type="nucleotide sequence ID" value="XM_002482104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MA05"/>
    <dbReference type="STRING" id="441959.B8MA05"/>
    <dbReference type="GeneID" id="8104371"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119210"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_2_1_1"/>
    <dbReference type="InParanoid" id="B8MA05"/>
    <dbReference type="OMA" id="ANIPWGP"/>
    <dbReference type="OrthoDB" id="72788at2759"/>
    <dbReference type="PhylomeDB" id="B8MA05"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF7">
        <property type="entry name" value="FLAVIN OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="2">
        <location>
            <begin position="43"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED18157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="412" mass="44859" checksum="EFE78B407A5D95AA" modified="2009-03-03" version="1">MTQPALPDVESKPAEGISYFTPAQNPIPGSAANPQSTGKPLPKLFQPLTVRGVTFQNRLALSPMCQYSAQDGHMTDWHMAHLGGYAQRGPGFLMIEGTAILPEGRITPQDVGLWKDSQIEPMRRIIGIQLFHSGPKGSNNAPWLQSSVIATEKVGGWPDNVKSASDIPFAPNYCQPKAMTKQDIEEFKSAWVAAVKRAIKAGVDFVEVHTAHGFLLNSFLTPYYNNRTDEYGGSFENGIRLSLEIAQLTRDTVGPDVPVFLRVSASDWVQESSESTWTIDDTVKFAEALAKQGAIDVIDVSSGGAHPAQKINSFPGFQVPFAVAIKKAVGDKLAVAAVGMLDTAELANKVLEEDGLDFALVGRGYLKNPNLVWKFAEELGVDFSIAHQIRWPFTGRGETAYIRPSTKNDAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAF3</accession>
    <name>B8MAF3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TAM domain methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_123840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482647.1">
        <property type="nucleotide sequence ID" value="XM_002482602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAF3"/>
    <dbReference type="STRING" id="441959.B8MAF3"/>
    <dbReference type="GeneID" id="8108295"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_123840"/>
    <dbReference type="eggNOG" id="ENOG502QSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8MAF3"/>
    <dbReference type="OMA" id="DNFIGCS"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="PhylomeDB" id="B8MAF3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="38653" checksum="50F27C6EB799E516" modified="2009-03-03" version="1">MATSDEGNAPAIDVDEQFENDSAWGQDDSASESTSVTSSIYRGLAENGRRYQTFREHIYWGPSDEKQFETMEAGHFMYSVLDYHEPNRLHRAPIGNSPEHILDIGTGKGSWAIDAADMYESATVRGIDLYPPPVGWVPPNCILEVDDVLEEWTWRQKFDLIHMRLLLGAFTPEEWDDVYRKCYNNLKPGGWIEQVELDVRVMSDDGTLPEDSLLAGWGPNFLGCGERSGRPLNTQTTMRAAIEKAGFRDVHEKLYKCPIGTWPKDPQLKDAGAINMEHWSSGLEGWAMWLLTKHGAPIPWSPDEVTVYVAKVRAELRNPKLHIYHYTRRVWGMKPTEVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBN0</accession>
    <name>B8MBN0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_119270</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482155.1">
        <property type="nucleotide sequence ID" value="XM_002482110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBN0"/>
    <dbReference type="FunCoup" id="B8MBN0">
        <property type="interactions" value="678"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MBN0"/>
    <dbReference type="GeneID" id="8104377"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119270"/>
    <dbReference type="eggNOG" id="KOG4163">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_4_1_1"/>
    <dbReference type="InParanoid" id="B8MBN0"/>
    <dbReference type="OMA" id="EVYWVTH"/>
    <dbReference type="OrthoDB" id="1350766at2759"/>
    <dbReference type="PhylomeDB" id="B8MBN0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00862">
        <property type="entry name" value="ProRS_anticodon_zinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.30:FF:000001">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000007">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000005">
        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="114"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED18163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="593" mass="66704" checksum="E181825BA4937C84" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBX6</accession>
    <name>B8MBX6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation-transporting ATPase</fullName>
            <ecNumber evidence="13">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSTA_121620</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="13"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482414.1">
        <property type="nucleotide sequence ID" value="XM_002482369.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B8MBX6">
        <property type="interactions" value="342"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MBX6"/>
    <dbReference type="GeneID" id="8098151"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_121620"/>
    <dbReference type="eggNOG" id="KOG0208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001828_3_1_1"/>
    <dbReference type="InParanoid" id="B8MBX6"/>
    <dbReference type="OMA" id="FSCFQYM"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="PhylomeDB" id="B8MBX6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990816">
        <property type="term" value="C:vacuole-mitochondrion membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903135">
        <property type="term" value="F:cupric ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07542">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000032">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000119">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000057">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000068">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047819">
        <property type="entry name" value="P5A-ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047821">
        <property type="entry name" value="P5B-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="540"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="576"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1067"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1105"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1143"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1190"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1220"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1257"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="domain" description="P5B-type ATPase N-terminal" evidence="15">
        <location>
            <begin position="157"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="14">
        <location>
            <begin position="393"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EED18422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1314" mass="147157" checksum="1CF2C5BA50492365" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCR1</accession>
    <name>B8MCR1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_126710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482955.1">
        <property type="nucleotide sequence ID" value="XM_002482910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCR1"/>
    <dbReference type="GeneID" id="8099098"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_126710"/>
    <dbReference type="HOGENOM" id="CLU_1631128_0_0_1"/>
    <dbReference type="InParanoid" id="B8MCR1"/>
    <dbReference type="OrthoDB" id="10650189at2759"/>
    <dbReference type="PhylomeDB" id="B8MCR1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="163" mass="18467" checksum="15DA6C8225D9226F" modified="2009-03-03" version="1" fragment="single">QYIILDRQGREHKVTNPIFMEDEYGFLSRKPGERGEIERSRQKPSTIGQSIEPILGFQHDKGAEIPIQVDIKNKTSHDRVRRPTQAALESAATETIYRRKSRQERRQEAREASKDTASRISLAREACLKEVANPAVVIELLLGDDDEFAYKAAKIGGEIPIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCV6</accession>
    <name>B8MCV6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD dependent epimerase/dehydratase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_113080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481474.1">
        <property type="nucleotide sequence ID" value="XM_002481429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCV6"/>
    <dbReference type="STRING" id="441959.B8MCV6"/>
    <dbReference type="GeneID" id="8105773"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_113080"/>
    <dbReference type="eggNOG" id="ENOG502SHS9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_8_6_1"/>
    <dbReference type="InParanoid" id="B8MCV6"/>
    <dbReference type="OMA" id="LYHMDSK"/>
    <dbReference type="OrthoDB" id="3358371at2759"/>
    <dbReference type="PhylomeDB" id="B8MCV6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF26">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED17482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="321" mass="35468" checksum="97D387B2AF0C3514" modified="2009-03-03" version="1">MSKLIVVTGITGVQGGSVARTYLNTPGWKVRGVTRNKSSERAKFWASNGVEMVEANLDDISSLKSAFQGANIIFGVTDFWTIFKDPESMTKKKPSQDITEYCFEVELQQGKNLADSAASIPALERYIFSSMANAIKSSYGKYRQLYHMDSKAFAADYAKSLPGLNGKFSQIQAPIYFNLTLLTDLMKNTDGTYRIKGIGSGDAPIPFGHVAKDFGPCVRAVANAEPGINLFAVGEELSWNRYLDTWCGSQGVLKGGYDEQSLDWWMEKLPGLGREFGENVLFSTEFGYAGNDPSVIRPSQLGVKMTTFREYCAETDFSRIL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-06-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MD74</accession>
    <name>SHO1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName>High osmolarity signaling protein sho1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Osmosensor sho1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">sho1</name>
        <name type="ORF">TSTA_114130</name>
    </gene>
    <organism>
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms homooligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SHO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481591.1">
        <property type="nucleotide sequence ID" value="XM_002481546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MD74"/>
    <dbReference type="SMR" id="B8MD74"/>
    <dbReference type="FunCoup" id="B8MD74">
        <property type="interactions" value="138"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MD74"/>
    <dbReference type="GeneID" id="8109175"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_114130"/>
    <dbReference type="eggNOG" id="ENOG502QW7A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043316_1_0_1"/>
    <dbReference type="InParanoid" id="B8MD74"/>
    <dbReference type="OMA" id="NIVWIFY"/>
    <dbReference type="OrthoDB" id="5983572at2759"/>
    <dbReference type="PhylomeDB" id="B8MD74"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007232">
        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11855">
        <property type="entry name" value="SH3_Sho1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000213">
        <property type="entry name" value="High osmolarity signaling protein SHO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035522">
        <property type="entry name" value="Sho1_SH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF20">
        <property type="entry name" value="HIGH OSMOLARITY SIGNALING PROTEIN SHO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0728">SH3 domain</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000410401" description="High osmolarity signaling protein sho1">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="2">
        <location>
            <begin position="36"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="66"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="2">
        <location>
            <begin position="96"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="125"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="222"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="178"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="281" mass="30259" checksum="3D2A83CEAB35FCB7" modified="2009-03-03" version="1">MPRFDPSNILGDPFALSTISISIIAWIISFIGSIIADVQTDFPNYAWWAVAYMICVIAGIIVVVGSDTTLIYSNAVVGYLSAGLAFTTLAVNSLVYQPQSSKQAAAAGFILLSMINIIWIFYFGSTPESSHRQAIDSLALNKVGNAYHNSRPASNAFGARPATTVSQPPQMYTSAQLNGFETSSPMSGYPGGPPGSDKRNTTATNFPPANVEPSNEVSQPTEYPYKAKAIYSYDANPDDANEISFTKGEELEVSDVSGRWWQARRANGETGIAPSNYLILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDC9</accession>
    <name>B8MDC9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exopolyphosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_116810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481884.1">
        <property type="nucleotide sequence ID" value="XM_002481839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MDC9"/>
    <dbReference type="FunCoup" id="B8MDC9">
        <property type="interactions" value="226"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MDC9"/>
    <dbReference type="GeneID" id="8102073"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_116810"/>
    <dbReference type="eggNOG" id="KOG4129">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019358_1_0_1"/>
    <dbReference type="InParanoid" id="B8MDC9"/>
    <dbReference type="OMA" id="DYKDWTE"/>
    <dbReference type="OrthoDB" id="374045at2759"/>
    <dbReference type="PhylomeDB" id="B8MDC9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="entry name" value="DHHA2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF39">
        <property type="entry name" value="EG:152A3.5 PROTEIN (FBGN0003116_PN PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01131">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA2" evidence="1">
        <location>
            <begin position="325"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="503" mass="55662" checksum="CDCE31A4D9104BE2" modified="2009-03-03" version="1">MPQDTSMNLGPSHITSSGLLPFLKHARHHFLPTIRNGITTYSPIYVLGNQSADLDSIISAILYSYVPLVNLTDVRGGSGLRRLRPEFACALELAVSSSSSSTASTEGKRDKDGEDGIVQLLKEHILTVADLREGLLSSPDVVNTDAEPKKMGNKLELDCVMVDWNNLPHKTSPQEEQGKGSIDGLSDLVSFTVTGCIDHRPDEGFVPPLGRLPEGSPRVIISGPGSCTSLVIREIRERVLWPVSSSEVHEERQRQHVSEGSEEGDWEVQLAKLALASILIDTTNLTAEGKVTDVDREAASFLTERISSSSPTGGGGKEWDRDSFFQKIQYAKAHSLDWLTVDEMLGRDYKDWTETTPSGDKKVIGIASVVRPLNWIIDKGEDEDDKSTTADDNLKSFLGKLKKFALERHLDVISVMTAFNTEDDGKEERFARELLVWGLEDDNSDALEKFANTAKKQLGLQKWNEFPIEGSHEYSGRLYIWKQGNVSQSRKQVAPLLRRAFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDP7</accession>
    <name>B8MDP7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mannosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_120260</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 22 family. PIGZ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482268.1">
        <property type="nucleotide sequence ID" value="XM_002482223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MDP7"/>
    <dbReference type="FunCoup" id="B8MDP7">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MDP7"/>
    <dbReference type="GeneID" id="8100010"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_120260"/>
    <dbReference type="eggNOG" id="KOG4123">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022957_2_0_1"/>
    <dbReference type="InParanoid" id="B8MDP7"/>
    <dbReference type="OMA" id="HGIHPRY"/>
    <dbReference type="OrthoDB" id="10066429at2759"/>
    <dbReference type="PhylomeDB" id="B8MDP7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF3">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 11 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002875006" description="Mannosyltransferase" evidence="12">
        <location>
            <begin position="26"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED18276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="536" mass="60717" checksum="E774C93DE1BC75CF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEE8</accession>
    <name>B8MEE8_TALSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_016520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483809.1">
        <property type="nucleotide sequence ID" value="XM_002483764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEE8"/>
    <dbReference type="GeneID" id="8106425"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_016520"/>
    <dbReference type="eggNOG" id="ENOG502SZXN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_607173_0_0_1"/>
    <dbReference type="InParanoid" id="B8MEE8"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="PhylomeDB" id="B8MEE8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="451" mass="49933" checksum="2410FF68019DB88C" modified="2009-03-03" version="1">MGQLSMSFVNTYYDAMAQIQSTPASQRPLQQQTIQGMIPLPGASHRRGLGVTNGQSTAMSVEQAHPQAAENDHRQRAPQHLPVSAAMSVPETSWAQIASASSSSDKPLPRSSPALTRIQPPEQPLPHPSPALSRIQPPEQPLPRSSPALSRIQPPEPPLPRSSPALTKTQPSERAESRANQSVKQHAAPCHNGGQITMQTAEMLPTGAASQQNDSETHGILEDGKAGIVVIKGPFRSIQNVLSFISTKIHEGPIYDMSMNKDQEVVVVFQYALHAQIFVDRNTECLATRQESVFGPGNWTVALGNPMEWTETLRRMAHPHRERRRLTFVKSRLFADHTSFQKWVREVQDVAGHANVDFVWAFNTGNATAVFFSVATARKVMQTFLNWKLNRGCYHELAVSYSSDPCEKDLLLTTQLRYHMIPPHRAFNRVGPNGAAGDRPSNGRPYYQSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEK5</accession>
    <name>B8MEK5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_017070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483866.1">
        <property type="nucleotide sequence ID" value="XM_002483821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEK5"/>
    <dbReference type="GeneID" id="8103680"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_017070"/>
    <dbReference type="HOGENOM" id="CLU_2943400_0_0_1"/>
    <dbReference type="InParanoid" id="B8MEK5"/>
    <dbReference type="OrthoDB" id="4207519at2759"/>
    <dbReference type="PhylomeDB" id="B8MEK5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED16632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="60" mass="7314" checksum="F5C925B1B5E83721" modified="2009-03-03" version="1">MEMSILVRNEFIDLLTGIQKYNYERAKCEDIKIIREDFDRVRDVIQEYEILSEDMPLRNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEM3</accession>
    <name>B8MEM3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Metalloprotease, putative</fullName>
            <ecNumber evidence="11">3.4.24.56</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_019680</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.56" evidence="11"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484140.1">
        <property type="nucleotide sequence ID" value="XM_002484095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEM3"/>
    <dbReference type="FunCoup" id="B8MEM3">
        <property type="interactions" value="1029"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MEM3"/>
    <dbReference type="MEROPS" id="M16.008"/>
    <dbReference type="GeneID" id="8104663"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_019680"/>
    <dbReference type="eggNOG" id="KOG0959">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004639_1_1_1"/>
    <dbReference type="InParanoid" id="B8MEM3"/>
    <dbReference type="OMA" id="LQSDCWR"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="PhylomeDB" id="B8MEM3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000003">
        <property type="entry name" value="Insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000005">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000004">
        <property type="entry name" value="Putative insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="7">
        <location>
            <begin position="22"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="8">
        <location>
            <begin position="209"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="9">
        <location>
            <begin position="394"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="10">
        <location>
            <begin position="789"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED16906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1022" mass="117204" checksum="815A16A341045C10" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8MF49</accession>
    <name>B8MF49_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">sn-1,2-diacylglycerol cholinephosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_012560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483382.1">
        <property type="nucleotide sequence ID" value="XM_002483337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MF49"/>
    <dbReference type="STRING" id="441959.B8MF49"/>
    <dbReference type="GeneID" id="8104104"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_012560"/>
    <dbReference type="eggNOG" id="KOG2877">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035066_5_0_1"/>
    <dbReference type="InParanoid" id="B8MF49"/>
    <dbReference type="OMA" id="GMWMYST"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="PhylomeDB" id="B8MF49"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000029">
        <property type="entry name" value="CDP-alcohol phosphatidyltransferase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF77">
        <property type="entry name" value="CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED16148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="423" mass="47680" checksum="6AA1BAD8082AF8E8" modified="2009-03-03" version="1">MPGIFKMVQAAQDSLSDEALLPLKTYKYSSVDKSYISNYILRHYWNAAVELLPLSIAPNMVTLLGFFFIITNVAFVTIFVPDLVGPGPTWIYYSFALGIWMYSTFDNIDGKQARRTGTSSGLGELFDHGIDSLNCTLASVLHTAAMGLGSTQIGAFTALIPCLPMFFSTWETYHTHTLYLGYFNGPTEGLLIAIVIMILSGIYGPQIWHNQVADVFGHKELFGTHSFLDYWVAIVFGSFMIAHLPACVYNVVQARRRQGLPVLPVFMEWTSIVIFTVSVMGWLFSPYSTLLAENHLVLFCIVMSFVFGRMTTKIILAHLIRQPFPYWTTMLVPLIGGAILANLPYLGFPAVSSGFELWYLRFYLIFAFVIYMHWAFLVINRITTFLGINCLTIKENKSAARDHVYRNFGEPRNNGEKAGLKHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B8MF57</accession>
    <name>B8MF57_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Valine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="4">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSTA_012640</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="4"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483390.1">
        <property type="nucleotide sequence ID" value="XM_002483345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MF57"/>
    <dbReference type="FunCoup" id="B8MF57">
        <property type="interactions" value="1180"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MF57"/>
    <dbReference type="GeneID" id="8108140"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_012640"/>
    <dbReference type="eggNOG" id="KOG0432">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_0_1_1"/>
    <dbReference type="InParanoid" id="B8MF57"/>
    <dbReference type="OMA" id="LDTWMDS"/>
    <dbReference type="OrthoDB" id="629407at2759"/>
    <dbReference type="PhylomeDB" id="B8MF57"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00817">
        <property type="entry name" value="ValRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000009">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000020">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000078">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000005">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004349">
        <property type="entry name" value="PRK05729.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14 19" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="17">
        <location>
            <begin position="115"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="18">
        <location>
            <begin position="782"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="990"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EED16156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1066" mass="119421" checksum="DDDF553B621E94E5" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFY6</accession>
    <name>B8MFY6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Benzoate 4-monooxygenase cytochrome P450, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_009730</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483087.1">
        <property type="nucleotide sequence ID" value="XM_002483042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFY6"/>
    <dbReference type="STRING" id="441959.B8MFY6"/>
    <dbReference type="GeneID" id="8102769"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_009730"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_11_1"/>
    <dbReference type="InParanoid" id="B8MFY6"/>
    <dbReference type="OMA" id="CRFYPWL"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="PhylomeDB" id="B8MFY6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED15853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="376" mass="43116" checksum="E8AE96610529393D" modified="2009-03-03" version="1">MMKDPVFSLITPTGIYLLPIDLLIPDKDACSLIHFQKALREQEAIIQRYVKKLMEQLTLRSSEGPQDVIRWFTFTTYDLIRGLLFGEQFGCVEDGEYDPFVQLIRNISKELTMIQMFNITASWERAQRVIATVDRRAKSKTNGKDFLHYILAAMETDKGIDGFNTFSLRIAGSESSATLLCGFIFYTLTHPTVRQKLITEVRDAFQSEDQIVMANVHHLTYLNAVLQECLRIYPPVAVTLPRVVPDGGEMIDGGYVAAGTTVGVNHFACYHDQRNFHRPNQFLPERWIPSAEDKTSPFSHDQRNCLQPFSLGPRNCLGKNLAWAEIRLITTHLLYLFDREPERSVGNRWTERQNVFGFWDKPPLLVHLTPKQKTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGX0</accession>
    <name>B8MGX0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GPR/FUN34 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_014420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483585.1">
        <property type="nucleotide sequence ID" value="XM_002483540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGX0"/>
    <dbReference type="FunCoup" id="B8MGX0">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MGX0"/>
    <dbReference type="GeneID" id="8107825"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_014420"/>
    <dbReference type="eggNOG" id="ENOG502QUJS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051062_0_1_1"/>
    <dbReference type="InParanoid" id="B8MGX0"/>
    <dbReference type="OMA" id="WKKGNTF"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="PhylomeDB" id="B8MGX0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047622">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01114">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED16351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="301" mass="32200" checksum="8BA49D1E194B2178" modified="2009-03-03" version="1">MASAPDAAPPLDKETTNLDNTGASTNGASPAAYPQMSREEHDVARAAARFGYGPLAQVNTHEARLPAFGGEFQPGLYRPVSDRKIANPAPLGLSAFALTTFVLGCINMGARDITEPNIVIGLAFGYGGLVQLLAGMWEMAVGNTFGATALSSYGGFWLAFAITLTPGGFNIVGALEAADHNSPIMFYNSFGLFLMGWFIFTFILLLCTLRSTVAFFSLFFTLDLAFLLLGIGYLVRENGAPDPKIIKAGGFFALLAAFLAWYNALAGIADSSNSFFIIPVAHFPWSEKGRERRAKVARDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGX8</accession>
    <name>B8MGX8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HypA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_014500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483593.1">
        <property type="nucleotide sequence ID" value="XM_002483548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGX8"/>
    <dbReference type="STRING" id="441959.B8MGX8"/>
    <dbReference type="GeneID" id="8107833"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_014500"/>
    <dbReference type="eggNOG" id="ENOG502S69W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019145_2_1_1"/>
    <dbReference type="InParanoid" id="B8MGX8"/>
    <dbReference type="OMA" id="DDGHMSK"/>
    <dbReference type="OrthoDB" id="10004862at2759"/>
    <dbReference type="PhylomeDB" id="B8MGX8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="53184" checksum="20899EAF32C9D819" modified="2009-03-03" version="1">MATTKTFKFGPRETPGLIHADTVTEESSRTLEELLEQNHSFHHIFTTTEDHKGVYFHNHIAHHDITIWALGATPATLRSQHERNGLYQRGPMAIQEPLVKDMADDRVFKRCLGREENFLNFCGFFEDYIDTYGYQALFQKYLVGGSEIADDMLCCIYMGYVHGIIHIGMALEFDQPRLLAEGFAQAAVHHDWWYTLYLQSAEALAAKAEEPAVPLSDCVDLCRADEKIRTCSSADYHTQTRPITGEMCLDREPARDGVMVKAKDEIIRIAARYRVDPNDLERATAELQNTAVYLTAGAQRPPYVCAFDFFLLHSVTSSIGHTMFLNEPSLTRAQKARLLEYTGRVYLMSYAGQGCPELRLDWLVSHLPKFPNQGWAEVFDRATYHEDDGHMSKLIRCMAHTQQTSKPYDHLPEFRFKQDMFLIAGIAAIDSGSAQPMEGTKHYDFIRGAGFEEAWKRFPIRSTVSSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGZ2</accession>
    <name>B8MGZ2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_014650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483607.1">
        <property type="nucleotide sequence ID" value="XM_002483562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGZ2"/>
    <dbReference type="GeneID" id="8107848"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_014650"/>
    <dbReference type="eggNOG" id="ENOG502SCMH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2224956_0_0_1"/>
    <dbReference type="InParanoid" id="B8MGZ2"/>
    <dbReference type="OrthoDB" id="2104739at2759"/>
    <dbReference type="PhylomeDB" id="B8MGZ2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED16373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="12287" checksum="77B3038B4C3D624A" modified="2009-03-03" version="1">MANLQIEFSESLFYKQNSFWVTKNPVFRTDQYSCVVTKLPDTTCEDHFPAELFEGINVRTNAAYIIPFKLGKFTNNAREQVRLWTTIYALFPELKDIIGQSSVNEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8MH03</accession>
    <name>B8MH03_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="3">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_018830</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; D-xylose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="3"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484051.1">
        <property type="nucleotide sequence ID" value="XM_002484006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MH03"/>
    <dbReference type="FunCoup" id="B8MH03">
        <property type="interactions" value="436"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MH03"/>
    <dbReference type="GeneID" id="8100993"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_018830"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="InParanoid" id="B8MH03"/>
    <dbReference type="OMA" id="DMYLVHT"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="PhylomeDB" id="B8MH03"/>
    <dbReference type="UniPathway" id="UPA00810"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032866">
        <property type="term" value="F:D-xylose reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042843">
        <property type="term" value="P:D-xylose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd19115">
        <property type="entry name" value="AKR_AKR2D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044487">
        <property type="entry name" value="AKR2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="14">
        <location>
            <begin position="18"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="13">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED16817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="320" mass="36056" checksum="F87436113BD6C39B" modified="2009-03-03" version="1">MSSPTVKLNSGYDMPLVGFGLWKVNNDTCADQVYAAIKAGYRLFDGACDYGNEKEVGQGIARAIKDGLVKREELFIVSKLWNTFHDGDKVEPIARKQLDDLGLDYFDLYLIHFPVALKWVDPAERYPPGWTAPDGKVEFSKATIQETWQAMESLVDKKLSRSIGISNFSVQLIMDLLRHARIRPATLQIEHHPYLQQKELIKYVQSEGIVITAYSSFGPLSFIELDMSSAHNTPKLFDHDVIKSTSQKHGKTPAQILLRWATQRNIAVIPKSNDPTRLSQNLDVTGWSLEQSDIDAINGLDLGLRFNDPLNYGIYIPIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8MH14</accession>
    <name>B8MH14_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_018940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484062.1">
        <property type="nucleotide sequence ID" value="XM_002484017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MH14"/>
    <dbReference type="GeneID" id="8101004"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_018940"/>
    <dbReference type="eggNOG" id="ENOG502RRZT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029564_0_0_1"/>
    <dbReference type="InParanoid" id="B8MH14"/>
    <dbReference type="OMA" id="FWTRREN"/>
    <dbReference type="OrthoDB" id="2448307at2759"/>
    <dbReference type="PhylomeDB" id="B8MH14"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF1">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED16828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="325" mass="37134" checksum="90A676E87419CD0E" modified="2009-03-03" version="1">MYLPNSKWTWLFVMTAVIQAAVILGLEAYVFADFQLHLHSFSDSASSSKTIPTFLSLYIFGFVYELILVYDALRLKNTIQIIGLCFCNIGLLIYGGLQIEQATQEENLWRQTKGIMIAIPCIIAFSSTFLIFVAWKLYDEFAWTIYKHISADLRMKRRYLTYQIYIALLKFDFFFFLGFTVQFVVIVTGKTDVEFALTLAAIPVTILILFFAAYFTRRENTLGMCAVILLYFGGLAYFLFKLVRMYQPSRAPEYIAARRSLTFFAVITILLILATIANAIACTINFHKGLKPHVMRPRKSTDDEKATELGTRVPGEGVPSRMMID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8MH35</accession>
    <name>B8MH35_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Uroporphyrinogen decarboxylase</fullName>
            <ecNumber evidence="4 14">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSTA_019110</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the sequential decarboxylation of four acetate groups of uroporphyrinogen-III (octacarboxyporphyrin) to yield coproporphyrinogen-III (tetracarboxyporphyrin) with the formation of intermediate hepta-, hexa- and penta-carboxylate porphyrinogens in the heme biosynthesis pathway. Acts on a number of porphyrinogens, but only coproporphyrinogen III can ultimately be converted to heme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>uroporphyrinogen I + 4 H(+) = coproporphyrinogen I + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:31239"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62626"/>
            <dbReference type="ChEBI" id="CHEBI:62631"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>uroporphyrinogen III + 4 H(+) = coproporphyrinogen III + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="4 14"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484083.1">
        <property type="nucleotide sequence ID" value="XM_002484038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MH35"/>
    <dbReference type="FunCoup" id="B8MH35">
        <property type="interactions" value="910"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MH35"/>
    <dbReference type="GeneID" id="8104607"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_019110"/>
    <dbReference type="eggNOG" id="KOG2872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040933_0_0_1"/>
    <dbReference type="InParanoid" id="B8MH35"/>
    <dbReference type="OMA" id="LWLMRQA"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="PhylomeDB" id="B8MH35"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000004">
        <property type="entry name" value="Uroporphyrinogen decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091">
        <property type="entry name" value="METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091:SF169">
        <property type="entry name" value="UROPORPHYRINOGEN DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9 14 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="16">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="17">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EED16849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="363" mass="40981" checksum="F1C63A1A67A20F8C" modified="2009-03-03" version="1">MQEQFEPLKNDLLLRAARGETVERPPVWVMRQAGRYLPEYHEAKGNRDFFECCRSPEIASTLTLQPVERYAGLIDAAIIFSDILVIPQAMGMIVEMIDKKGPSFPEPLISPDDGQYEKILKKDVDVKKELDYVYKAITLTRFKLKGRVPLIGFCGAPWTLLCYMVEGGGTKLFIQSKKWIYKYPNESKAMLQKIAEICVEYLALQVAAGAQLVQVFDSWAGELSPATFKEFALPYLRHISQHLPKRLQELGLERVPMTVFAKGAWYALDDLCESGYNVVGLDWLHDPAEAYSVARGRVALQGNADPGILYGDRNAITKTVENMVKGFGGGKKGWIANLGHGITPFVNPDDLKFFFEEIHRHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MH69</accession>
    <name>B8MH69_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Epimerase/dehydratase family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_019450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484117.1">
        <property type="nucleotide sequence ID" value="XM_002484072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MH69"/>
    <dbReference type="STRING" id="441959.B8MH69"/>
    <dbReference type="GeneID" id="8104640"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_019450"/>
    <dbReference type="eggNOG" id="KOG1430">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045030_1_0_1"/>
    <dbReference type="InParanoid" id="B8MH69"/>
    <dbReference type="OMA" id="PQTAWLN"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="PhylomeDB" id="B8MH69"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF11">
        <property type="entry name" value="LD23561P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="371" mass="42035" checksum="4E135CE1836FAF52" modified="2009-03-03" version="1">MATDKPAVLIIGGLGFVGRHLALHIHKNNLASELRIVDKLLPQLAWLAPEFEQACSKEQFVQADASREQSYPRIFDRADGKQFDYVINCAADTRPSQPEEVYQLRNHAMCMGLAKEVAKRNIKVYAQASTSYIYKSGSKPAKEDDKKKPWHNLAKWQLQVEEDLPGVEGLNWVSLRLPHIYGEYDRGYTAVAIALARTHQWLQTGFDQLESKDLKFNTLHVKDAACALWTAAEWRAGEKDNKDAPHIFNVVDHTDTTRDQIGAALAEVFDLKVTFAGMLVSQLARLKLNDIVDEMNEEMLQAWADMLEEKGITRPGPISPFIEIDMLSDNDLCIDGSLFESTTGFQLEYPRFSSDSIREVIASYERMGWWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHT1</accession>
    <name>B8MHT1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_015000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483645.1">
        <property type="nucleotide sequence ID" value="XM_002483600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHT1"/>
    <dbReference type="STRING" id="441959.B8MHT1"/>
    <dbReference type="GeneID" id="8106242"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_015000"/>
    <dbReference type="eggNOG" id="ENOG502SPG6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036632_5_1_1"/>
    <dbReference type="InParanoid" id="B8MHT1"/>
    <dbReference type="OMA" id="KCFNIVA"/>
    <dbReference type="OrthoDB" id="3918601at2759"/>
    <dbReference type="PhylomeDB" id="B8MHT1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="2">
        <location>
            <begin position="30"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED16411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="359" mass="40043" checksum="82ADE8A08439D1F0" modified="2009-03-03" version="1">MSRFTGDVHTSPIMVVSWFLLVVAMIAVFIRLGTKTWIFRKFHKDDYIIIASAIFDIGQIVCLSIAGANGYGRHIKTLSDEQVEIIQKCQYAQHELIIMTMTLSKISFIMFVRSITAVPLDHMVALGLIAATWGWAIAFLISGALQCRAPEPWNYLGKNCFNQRIWNDFFSLGDILTDVGIVIYTMIIIGRIHTKLSRRIGLAIVFGMRVLVIAAITVHITTLNKSLAADDSTYETWIATIASQIAICLSNVTACSPQFKPFLESLQSSGMRLDTTMTAGTRTADSYTGSKGFNLRSITGRGRRNDNMPYVKTIVSASPNSALDWDISSQHSQSRIIMETRTVTVVEERRRAHFAEDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8MI73</accession>
    <name>B8MI73_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_040370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MI73"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_040370"/>
    <dbReference type="eggNOG" id="ENOG502RKS6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_912698_0_0_1"/>
    <dbReference type="InParanoid" id="B8MI73"/>
    <dbReference type="OMA" id="HREAHYH"/>
    <dbReference type="OrthoDB" id="4384180at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED14557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="305" mass="34011" checksum="B5213F8790AF0FFF" modified="2009-03-03" version="1">MTRHLATLRACGTQAFQPVIRLYLKPPSGHREAHYHLVVELHPYPGVSWAQIPLVRTSSKLVVKRTPDGRSLPRASTTRCWRAPAGCPASAHLLQGLPPKAQRARPLEPILIPKGCSPWRPAAVMSTTWRENYSFPRIFKDRRGRTGPGKGAELCQPWNPSSGQTDFRVIGCQEEKRTLPRTPADVSAFSYVAVENPHPGAGILTGFPFDGRRTRAHFQTELPYVLDRLTHVQLLFTWNLSPLQSSKFSFEYLLLPPRSAVGAVRPGITPKDSSRTPTPAYSSGHRFYPDGEVWVARLSAIHFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIF9</accession>
    <name>B8MIF9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin reductase GliT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_041210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484596.1">
        <property type="nucleotide sequence ID" value="XM_002484551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIF9"/>
    <dbReference type="STRING" id="441959.B8MIF9"/>
    <dbReference type="GeneID" id="8109706"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_041210"/>
    <dbReference type="eggNOG" id="ENOG502QQDE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_0_1"/>
    <dbReference type="InParanoid" id="B8MIF9"/>
    <dbReference type="OMA" id="QHMHNVL"/>
    <dbReference type="OrthoDB" id="10260355at2759"/>
    <dbReference type="PhylomeDB" id="B8MIF9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097237">
        <property type="term" value="P:cellular response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="4">
        <location>
            <begin position="7"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED14643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="319" mass="35155" checksum="5836C091F1F35215" modified="2009-03-03" version="1">MLSPTLYDALIIGAGPAGLSVATGLARQLHTAAVFSSSVFRNAKVKHMHNVLGWDHRSPTDFRAKARADLLARYSTVQFYDEVEIESVSRQSDGRFEARDVRGDVWRGKKLVLAMGVKDIFPDIEGYEDCWGETIHHCLFCDGYEKRGAPSAGVLATDVLETNQRAMHVNRMARRLVDKVTIYTNGNNEQASTFREAIAALDGFKVDPRPFMKLEKKREMDGNEPKIIIHFKDGTCAEEAFLAHGPRYVLNGPFAQQLSLETVETGELKVSPMFNETSMPGVFAVGDCATPMKAVTPAIAMGTGTAAAIVMQLQEEKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIP1</accession>
    <name>B8MIP1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSTA_045890</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 15">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485086.1">
        <property type="nucleotide sequence ID" value="XM_002485041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIP1"/>
    <dbReference type="FunCoup" id="B8MIP1">
        <property type="interactions" value="1200"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MIP1"/>
    <dbReference type="GeneID" id="8107576"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_045890"/>
    <dbReference type="eggNOG" id="KOG1376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015718_1_0_1"/>
    <dbReference type="InParanoid" id="B8MIP1"/>
    <dbReference type="OMA" id="YMASCIL"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="PhylomeDB" id="B8MIP1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000008">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="16">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="17">
        <location>
            <begin position="248"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EED15133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="450" mass="50419" checksum="829444BB405CDB1A" modified="2009-03-03" version="1">MREVISLNVGQAGCQIANSCWELYCLEHGIQPDGYLTEERKAQEPDEGFSTFFSETGQGKYVPRTIYCDLEPNVVDEVRTGTYRSLFHPEQMVTGKEDASNNYARGHYTVGKEMIDRVLDQVRRVADNCAGLQGFLVFHSFGGGTGSGFGALLMERLSVDYGKKSKLEFCVYPAPQNGTSVVEPYNSILTTHTTLEHSDCSFMVDNEAIYDICRRNLGIERPGYENLNRLIAQVVSSITASLRFDGSLNVDLNEFQTNLVPYPRIHFPLVAYAPVISAAKSLHEANSVNEITMSCFEPNNQMVKCDPRNGKYMATCLLYRGDVVPKETHAAVATLKTKRTIQFVDWCPTGFKIGICYQPPQMVPNGDLAKVNRAVCMLSNTTAIAEAWSALDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALERDYEEVASDSLEEDEEVEAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIR1</accession>
    <name>B8MIR1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EKC/KEOPS complex subunit GON7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_050110</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit KAE1 in the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GON7 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485526.1">
        <property type="nucleotide sequence ID" value="XM_002485481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIR1"/>
    <dbReference type="GeneID" id="8108775"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_050110"/>
    <dbReference type="eggNOG" id="ENOG502T1MI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146833_2_1_1"/>
    <dbReference type="InParanoid" id="B8MIR1"/>
    <dbReference type="OMA" id="PFKVAHT"/>
    <dbReference type="OrthoDB" id="2288868at2759"/>
    <dbReference type="PhylomeDB" id="B8MIR1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014849">
        <property type="entry name" value="EKC/KEOPS_Gon7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08738">
        <property type="entry name" value="Gon7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0779">Telomere</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="61"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED15573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="96" mass="10692" checksum="A873835621CAA467" modified="2009-03-03" version="1">MTTHKPAISAAYSSSQPPHTSYTFRHKIAASLETNSPQQSVAAKKAYLSELREVNVFLTERMEEDKKRAGEGTGKDAEQEAKEEENYGEENVEDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJM5</accession>
    <name>B8MJM5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_051610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485677.1">
        <property type="nucleotide sequence ID" value="XM_002485632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJM5"/>
    <dbReference type="STRING" id="441959.B8MJM5"/>
    <dbReference type="GeneID" id="8103382"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_051610"/>
    <dbReference type="eggNOG" id="ENOG502SJME">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038496_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJM5"/>
    <dbReference type="OMA" id="AYLEDEW"/>
    <dbReference type="OrthoDB" id="4502264at2759"/>
    <dbReference type="PhylomeDB" id="B8MJM5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13384">
        <property type="entry name" value="HTH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="378" mass="44522" checksum="ED7446DBA2EC64D9" modified="2009-03-03" version="1">MAREEYSVEIRAQIVSLVMIAKMKPQDVATLLNIPRVSVYQIIQRAKEHGYDPTVNPRIEHEHVANKECSGRPKVVTEAIEASIIASVTKDRAGREKSAEYLAYEADFKNIIWTDEISVVLGHRRGSNCVWRRSFECYDPTVIRRRYKGACEFMFWVAFPMMPRVPVTFIKRRMQQQQKKAEKELEVINREREKVAREEWELNGAFSRLQLRPRPGRKPTFRFTAKNGKLVRNSKGGIDWYRYQKEVLVPKLLPFAQECKRSRLDTIRLLWLGNSPDLNAIEPTWFWLKKRTTLRGAPGDRKTAVGVWEKAWERLPQHRIQAWIERIPFHIQEIIRLEGKNEYPEGRPQGDVRSRCRRKGMLSFRAYLEDEWEGLEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8MK39</accession>
    <name>B8MK39_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zinc transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_043310</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a zinc transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484809.1">
        <property type="nucleotide sequence ID" value="XM_002484764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MK39"/>
    <dbReference type="FunCoup" id="B8MK39">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MK39"/>
    <dbReference type="GeneID" id="8104973"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_043310"/>
    <dbReference type="eggNOG" id="ENOG502QV77">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024994_1_1_1"/>
    <dbReference type="InParanoid" id="B8MK39"/>
    <dbReference type="OMA" id="KECRSSM"/>
    <dbReference type="OrthoDB" id="5382797at2759"/>
    <dbReference type="PhylomeDB" id="B8MK39"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF5">
        <property type="entry name" value="ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="166"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED14856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="461" mass="50281" checksum="699768EE5892C6E3" modified="2009-03-03" version="1">MASSSLPIPQPPRTPSPSPDSQDQRSLAPEPQYDPKALSPMHGIMQSERLNVNAPNMAPTSPTSPSFGAFPTHGSNTNAGSGTVDPNPFNFQPMALAKSPVMKSNIGQRRGHKYKHSSISHQIFLEPPPRAPLALPASLPIPTLKECRSSMSKDQKTRFWWSVCHMLIAGYTLWSAHGSLAMMALSHLILFDSLGALLCVIVDVLGNFEVWKRSSVRHPFGLERAEVLAGFASSVLLVFMGMDLISHNLQHWLESSPGHQPHHSHEHDRVSAGSVDLTAILAIGSTLVSAIGLKNHARIGKSMRFAYIESLPSVLSNPSHFLTLSCSALLLILPLLSVSLYSWLDKLLSLSMAISMCILGSRIVKTLGSMLLMSFSGNGVNDVMRDIQADPAVTAIDDARFWQVHYGLCMANLKLRVTGTEETLIKLREKITSLIRNRLGGGYGSGGQKWEVTLQFTAERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLB5</accession>
    <name>B8MLB5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSTA_044940</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484983.1">
        <property type="nucleotide sequence ID" value="XM_002484938.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B8MLB5">
        <property type="interactions" value="941"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MLB5"/>
    <dbReference type="GeneID" id="8104170"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_044940"/>
    <dbReference type="eggNOG" id="KOG0261">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000487_3_0_1"/>
    <dbReference type="InParanoid" id="B8MLB5"/>
    <dbReference type="OMA" id="AVCPPYN"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="PhylomeDB" id="B8MLB5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02736">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02583">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035698">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035697">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015700">
        <property type="entry name" value="RPC1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14 16" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="15">
        <location>
            <begin position="264"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EED15030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1441" mass="161360" checksum="D89039508B6E1C51" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLF0</accession>
    <name>B8MLF0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit 5, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_049220</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase delta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485436.1">
        <property type="nucleotide sequence ID" value="XM_002485391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLF0"/>
    <dbReference type="FunCoup" id="B8MLF0">
        <property type="interactions" value="723"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MLF0"/>
    <dbReference type="GeneID" id="8100638"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_049220"/>
    <dbReference type="eggNOG" id="KOG1662">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085114_0_0_1"/>
    <dbReference type="InParanoid" id="B8MLF0"/>
    <dbReference type="OMA" id="MVDNIQD"/>
    <dbReference type="OrthoDB" id="1262810at2759"/>
    <dbReference type="PhylomeDB" id="B8MLF0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020781">
        <property type="entry name" value="ATPase_OSCP/d_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="ATP SYNTHASE DELTA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00389">
        <property type="entry name" value="ATPASE_DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED15483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="226" mass="24135" checksum="A5EA175CC710AD31" modified="2009-03-03" version="1">MLSARVAARAGLRNFQVPRSVAVGGLRTYAAAAQQDVRPPVALYGVDGTYANALYTASAKTSSLDSIAKSLSQLGEVFKKDAKLTTILNAPTLSVSDKQQIIKELQTVAGGDKNDILKNFLSTLAENNRLGLLEGVIEKFQTLMSAHKGEIELSITSAQELDTKSIQRIEKAVAKSEISQGKKLKVVTKVNPDVLGGLIVEVGDRTIDLSVSSKINRLNKALTDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLF5</accession>
    <name>B8MLF5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase regulator (Mob1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_049250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485439.1">
        <property type="nucleotide sequence ID" value="XM_002485394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLF5"/>
    <dbReference type="FunCoup" id="B8MLF5">
        <property type="interactions" value="522"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MLF5"/>
    <dbReference type="GeneID" id="8100641"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_049250"/>
    <dbReference type="eggNOG" id="KOG0440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038321_4_1_1"/>
    <dbReference type="InParanoid" id="B8MLF5"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="PhylomeDB" id="B8MLF5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035974">
        <property type="term" value="C:meiotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071958">
        <property type="term" value="C:new mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071957">
        <property type="term" value="C:old mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902554">
        <property type="term" value="C:serine/threonine protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034973">
        <property type="term" value="C:Sid2-Mob1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903473">
        <property type="term" value="P:positive regulation of mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031031">
        <property type="term" value="P:positive regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED15486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="262" mass="29817" checksum="FF0ACB4B1DAE2170" modified="2009-03-03" version="1">MSTLSAGTGTLSHSDSTKTIKARHHYLPIEPPSYLSTAVRGLKGSLHVLTPPSNARTKGPFKPRSSRGTTSYQLRKFAEETLGSGSLRKAVKLPEGEDVNEWLAVNVVDFYNQINLLYGSITEFCSPQSCPEMKATDEFEYLWQDSENYKRPTKMSAPEYIEHLMAWVQGNIDNEQMFPSRTGVPFPKTFPALIRQMFKRLYRVYAHIYCHHYHVILKLGLEPHLNTSFKHYVLFIDEHTLASGKDFWGPLGDLVESMLKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLI6</accession>
    <name>B8MLI6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thij/pfpi, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_049560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485472.1">
        <property type="nucleotide sequence ID" value="XM_002485427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLI6"/>
    <dbReference type="STRING" id="441959.B8MLI6"/>
    <dbReference type="GeneID" id="8102117"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_049560"/>
    <dbReference type="eggNOG" id="ENOG502SQ0U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_44_8_1"/>
    <dbReference type="InParanoid" id="B8MLI6"/>
    <dbReference type="OMA" id="HHIGITR"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="PhylomeDB" id="B8MLI6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03139">
        <property type="entry name" value="GATase1_PfpI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF7">
        <property type="entry name" value="DJ-1_PFPI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002875205" evidence="1">
        <location>
            <begin position="24"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="DJ-1/PfpI" evidence="2">
        <location>
            <begin position="111"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED15519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="270" mass="30329" checksum="647F1D34DDE65077" modified="2009-03-03" version="1">MDELRFRAAMLCLVLDSRAVVHAEEVLYCNYLRAEMAPIHFGSLVYDYQAMDVIGPFDLIGSGGRFILDAVSFFTDIDRKLIDRAPEFVFHHIGETLDPVRLLTSSLVVNPTDTLDDCPELDYLLVGGPNIKDFKLSPRYAEFIRRHVAAGKIVFTTCTGAAVLASTGVLDGKRATINNLEYEFARKQYPKVKWTKETKWVVDGNIWTGSGAVAGMDMFAHWFKESFGLDLLTEASKGLDYEPRDINGLFKVFPQRYDENGVQLSTLVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MM69</accession>
    <name>B8MM69_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alcohol dehydrogenase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_098380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485819.1">
        <property type="nucleotide sequence ID" value="XM_002485774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MM69"/>
    <dbReference type="STRING" id="441959.B8MM69"/>
    <dbReference type="GeneID" id="8099666"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_098380"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1176084_0_0_1"/>
    <dbReference type="InParanoid" id="B8MM69"/>
    <dbReference type="OrthoDB" id="5407715at2759"/>
    <dbReference type="PhylomeDB" id="B8MM69"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF33">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED13581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="26473" checksum="54CE6497195FEB8A" modified="2009-03-03" version="1">MNEGSKKLSHSMLCQQLGYTTKDLVYMAHLLVPFGGLRDIKLEPGETVVICPATGGFSGAGVQIAAAMGCKVIAMGRDEKELARLKEFEENRLPSAAVEAVKITHDEKKDTAHCCRYIAERAGWRWPYWVSLYAAGVVTVGNILLNTETNSIILMRRKAVRLRKELNRPELQFVFNSKDEIDMSMTTVLSRGIVRPVRMLFGTPILLLLATYMSFVFGLLYLLFTTLTSLYISTYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8MM97</accession>
    <name>B8MM97_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc-binding oxidoreductase ToxD, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_099060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485889.1">
        <property type="nucleotide sequence ID" value="XM_002485844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MM97"/>
    <dbReference type="FunCoup" id="B8MM97">
        <property type="interactions" value="278"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MM97"/>
    <dbReference type="GeneID" id="8103984"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_099060"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_1_1"/>
    <dbReference type="InParanoid" id="B8MM97"/>
    <dbReference type="OMA" id="CVHGANA"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="PhylomeDB" id="B8MM97"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="7"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED13651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="347" mass="37418" checksum="96A0CEE9373DB950" modified="2009-03-03" version="1">MKAVVVQNKTPTLATDRAVPKLRDDYILVKPVAVALNPTDWKHAAFGLAADGGLLGCDFAGVVEEVGSKVTKQWKKGDRLAGVAHGGNLVQPEDGAFAEHILAKGDIQIKIPDSLSFEDAASLTLGINTVMQGLFQKALKLNWPSDPVKDQTPVLIYGGSTATGALGIQFAKLAGYAVITTCSPRNFDYVKSLGADKTFDYNEPNVGAKIREYTQDNLKYAWDTISDENSAKICADALTSESGAKYGNILTAKSPREDVETVNTLMYTVFGEEFKFGAQPFPAIPEDFEYTKKFIALVEKLLAEGKLKAHRVKVGADGLKGVLAGLEDLKNGKVSGEKLVYRVEETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8MN02</accession>
    <name>B8MN02_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_101870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486189.1">
        <property type="nucleotide sequence ID" value="XM_002486144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MN02"/>
    <dbReference type="GeneID" id="8099232"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_101870"/>
    <dbReference type="eggNOG" id="ENOG502SUVM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039092_0_0_1"/>
    <dbReference type="InParanoid" id="B8MN02"/>
    <dbReference type="OrthoDB" id="5099562at2759"/>
    <dbReference type="PhylomeDB" id="B8MN02"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="186" mass="20882" checksum="9E95DDA5F97ADB01" modified="2009-03-03" version="1">MEEDPAVTTRVGRVVVPSTRAREALEGADSTDATTATRRTTSKVKPTAVRKAANQIEERQCAQDENQMILRKMCQYLEGIYREVKILKETLRTKRHDQETTGLNRSNLKLSCRRLQATPGAARYHRESQGIRLGPLGPPVPPTIANILFCTIDTSHVREEDKAKAQIANVRQMIKKEIQGNEGMET</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B8MP45</accession>
    <name>B8MP45_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_104980</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486522.1">
        <property type="nucleotide sequence ID" value="XM_002486477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MP45"/>
    <dbReference type="FunCoup" id="B8MP45">
        <property type="interactions" value="1241"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MP45"/>
    <dbReference type="GeneID" id="8098719"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_104980"/>
    <dbReference type="eggNOG" id="KOG0861">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074848_0_1_1"/>
    <dbReference type="InParanoid" id="B8MP45"/>
    <dbReference type="OMA" id="HYIGIIR"/>
    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="PhylomeDB" id="B8MP45"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033106">
        <property type="term" value="C:cis-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016409">
        <property type="term" value="F:palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061909">
        <property type="term" value="P:autophagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15867">
        <property type="entry name" value="R-SNARE_YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000020">
        <property type="entry name" value="synaptobrevin homolog YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045848">
        <property type="entry name" value="R-SNARE_YKT6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Longin" evidence="10">
        <location>
            <begin position="7"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="139"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED14284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="199" mass="22809" checksum="EBE74CE2E0EEA612" modified="2009-03-03" version="1">MKIYYMGILRNETKPALELSGEKDLSSFSRFTRENYNEFMMLFTKTVAERTKPGQRQTIEEKSYTFHSMSRDGIAGVIVSDSEYPPLVAQQLLSKITDEFISKHPHCEYANPTLPERSLSFPQLAEYIKKYQDPSQADSIMKIQQELDQTKIVLHKTIESVLERGEKIDSLVAKSDGLSAQSKMFYTQAKKQNSCCIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B8MP81</accession>
    <name>B8MP81_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_105320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486558.1">
        <property type="nucleotide sequence ID" value="XM_002486513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MP81"/>
    <dbReference type="GeneID" id="8098753"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_105320"/>
    <dbReference type="HOGENOM" id="CLU_1012589_0_0_1"/>
    <dbReference type="InParanoid" id="B8MP81"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED14320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="275" mass="32882" checksum="CFD3067915F3A442" modified="2009-03-03" version="1">MNQNQRRQRSRIPTPAPRAQFARPRLERVDNNPRTRLRDEATAREQATQQQATQRATLERENRTLRAQVRKLQHEQAALREHAAQRARLERVTRDLRERAAREQVAQDRDTLEQENNTLWARVRNFRNQRNRLRQQNITLDVRRRRQVNILLATLVAQRLRSNFLAHEHNEMQQQRDNALQEHDWMRQDYDQLSEDLQRTRNQNEEETTSLLIQISEFSKRADLLDKALLEAGLQITETTNDNPKTSINKSSRSRNKLRLQLVRWRSQGQVETIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQE7</accession>
    <name>B8MQE7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myosin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Class I unconventional myosin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Type I myosin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">TSTA_058370</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Plays an important role in polarized growth, spore germination, hyphal morphogenesis, and septal wall formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487460.1">
        <property type="nucleotide sequence ID" value="XM_002487415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQE7"/>
    <dbReference type="FunCoup" id="B8MQE7">
        <property type="interactions" value="362"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MQE7"/>
    <dbReference type="GeneID" id="8106439"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_058370"/>
    <dbReference type="eggNOG" id="KOG0162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000192_7_6_1"/>
    <dbReference type="InParanoid" id="B8MQE7"/>
    <dbReference type="OMA" id="NDQENQC"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="PhylomeDB" id="B8MQE7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001411">
        <property type="term" value="C:hyphal tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:microfilament motor activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:actin cortical patch localization"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd11858">
        <property type="entry name" value="SH3_Myosin-I_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Myosin I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000254">
        <property type="entry name" value="Myosin I MyoA/Myo5"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.20.5.4820:FF:000004">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.20.58.530:FF:000007">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Fungal_myosin-I_SH3"/>
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    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
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    <dbReference type="InterPro" id="IPR054489">
        <property type="entry name" value="Myo1_CA"/>
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    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
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        <property type="entry name" value="Myosin_TH1"/>
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    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
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    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
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    <dbReference type="PANTHER" id="PTHR13140:SF837">
        <property type="entry name" value="MYOSIN-3-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF22773">
        <property type="entry name" value="Myo1_CA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Myosin_TH1"/>
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        <property type="entry name" value="SH3_1"/>
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        <property type="entry name" value="MYOSINHEAVY"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 19" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="10 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 19" id="KW-0505">Motor protein</keyword>
    <keyword evidence="11 19" id="KW-0518">Myosin</keyword>
    <keyword evidence="8 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
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    <keyword evidence="7" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="60"/>
            <end position="739"/>
        </location>
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        <location>
            <begin position="797"/>
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        <location>
            <begin position="1093"/>
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    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
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    <feature type="region of interest" description="Actin-binding" evidence="19">
        <location>
            <begin position="612"/>
            <end position="634"/>
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        <location>
            <begin position="967"/>
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    <feature type="region of interest" description="Disordered" evidence="20">
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        <location>
            <begin position="1162"/>
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        <location>
            <begin position="17"/>
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        <location>
            <begin position="977"/>
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        <location>
            <begin position="1022"/>
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            <begin position="1077"/>
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        <location>
            <begin position="1166"/>
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            <begin position="1210"/>
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        <location>
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        <ligand>
            <name>ATP</name>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00032645"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50002"/>
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        <source>
            <dbReference type="PROSITE" id="PS51456"/>
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        <source>
            <dbReference type="PROSITE" id="PS51757"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED13349.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1263" mass="139150" checksum="0C92351EC3B7A810" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQG8</accession>
    <name>B8MQG8_TALSN</name>
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        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">TSTA_058590</name>
    </gene>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED13370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002487436.1"/>
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    <dbReference type="PhylomeDB" id="B8MQG8"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
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    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
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    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
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    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="12"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED13370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="356" mass="37956" checksum="585139D4B91EDF8F" modified="2009-03-03" version="1">MARQWILNSQDGFEASLEYQQNVIVPSAAKLGPTEVLVKLHAASLNYRELVIAGPIGVNGPITAPIVPGCDGAGIVEAVGSSVHEFRPGDRVVTYAVPKLAESDGDDAFSSVTDVPYMMGQGIDGTLRSMGVFPEKGLVHAPKSLDWLPAATLTCNWTTAWNALFGLKGREAGPGTWVLVQGTGGVSIATLQVAVAAGATVVATTSTEEKAARLRKLGAAHTINYRSNPDDWALQAKRLTPGGRGFDIVVDVGGNETLRQSLAAIRVDGQVLVLGAVGGTAENVPLFAVLLSTCIVRGFLCGSRRQLKEVIQFIDEKNITPAMDDVVFELAEAKDAYRRLKEKKHFAKVLIRIDHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQI7</accession>
    <name>B8MQI7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIF subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TFIIF medium subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TFIIF-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_058770</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487500.1">
        <property type="nucleotide sequence ID" value="XM_002487455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQI7"/>
    <dbReference type="FunCoup" id="B8MQI7">
        <property type="interactions" value="502"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MQI7"/>
    <dbReference type="GeneID" id="8106479"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_058770"/>
    <dbReference type="eggNOG" id="KOG2905">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047858_0_2_1"/>
    <dbReference type="InParanoid" id="B8MQI7"/>
    <dbReference type="OMA" id="ANCPEHQ"/>
    <dbReference type="OrthoDB" id="26094at2759"/>
    <dbReference type="PhylomeDB" id="B8MQI7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07980">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000035">
        <property type="entry name" value="General transcription factor IIF subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="12">
        <location>
            <begin position="48"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="11">
        <location>
            <begin position="260"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED13389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="363" mass="41444" checksum="38E8D23B38F75D9E" modified="2009-03-03" version="1">MAAPVKQEPGTTSFIKPDPDSKEGLPGALSDDDLYEDAGDLDFTQAGQNVWLTRIPTDLWKYWSQLDDDEEIQIGTVRVEGEPHDIKRISLRLNDDPNSKDIPKDYILQRQNVDPKSGSFAVQNSYIFSEKDLPGHKNKVDEMFGETRSMLYESMKREARKKATKRKWEPYVRKTIPKQTALVGKVADEFNCMPVENAEYQRISEAKALKALEPREKVRLIDLRQHKGPNVREVAAGTVGGFVQQAKPAKARTQENKATRRERNVLLDEIFGLFREYSHWKFADIKARTNQPEQYLKETLEMVAHLVRTGDFAMTWELKPEAREANYANIILGQAGEENGAIKNDPDEEMGGDEDEDVQFENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8MR65</accession>
    <name>B8MR65_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_054700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487071.1">
        <property type="nucleotide sequence ID" value="XM_002487026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MR65"/>
    <dbReference type="GeneID" id="8100477"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_054700"/>
    <dbReference type="HOGENOM" id="CLU_1111966_0_0_1"/>
    <dbReference type="InParanoid" id="B8MR65"/>
    <dbReference type="PhylomeDB" id="B8MR65"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="250" mass="27154" checksum="D2D8D3D727251443" modified="2009-03-03" version="1" fragment="single">MMITLDEIIPYQPPLPPKPCISSKTIPPPSKLPPLIHPLPQKPQSRHQSPSCPSQLHQSKCDHIPSPIDQEQMSGVPLYTNVFDRELAAWSDMAIKTTAFVSTATENTEQQQHHIGSDLFENGPRKLLSGDQSDNVQHASHDDEASPSISAGFLGHDRSCSAHQETTQLIHASESNGIHATLSKPPVRPSRNLPPRVRSSESRSGNVIPDTAHLDNMDSPHASSGTINPAESPNSIVPDHSMPVLPGSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRF7</accession>
    <name>B8MRF7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Xenobiotic compound monooxygenase, DszA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_055940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487205.1">
        <property type="nucleotide sequence ID" value="XM_002487160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRF7"/>
    <dbReference type="STRING" id="441959.B8MRF7"/>
    <dbReference type="GeneID" id="8100659"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_055940"/>
    <dbReference type="eggNOG" id="ENOG502QSR6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022256_0_0_1"/>
    <dbReference type="InParanoid" id="B8MRF7"/>
    <dbReference type="OMA" id="HGLKEQI"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="PhylomeDB" id="B8MRF7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF41">
        <property type="entry name" value="XENOBIOTIC COMPOUND MONOOXYGENASE, DSZA FAMILY (AFU_ORTHOLOGUE AFUA_3G15040)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="3">
        <location>
            <begin position="48"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="451"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED13094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="483" mass="53697" checksum="4E223326EE1AC59B" modified="2009-03-03" version="1">MTETIPSATSVSPKKQIILNAFVMNTPGHQAPGLWRHPRNKTDQYKKLCFWTDLAQLLDKAGFHAMFIADTLGPYDVYKGPANVVPALASGAQFPVNDPLFLVPTMASVTKNLIFGVTASLTYEKPYALARSQGRVAWNIVTSYLDSAARNHGLKEQIPHDERYAIAHEYMEVLYKLWEGSFRDDAVLEDRENGIYIANDAVRQINHKGKYFEVPGPHFCEPSPQRTPFLFQAGVSEAGNGFGGKHGEAIFIGGQTPEGVRATVDNIRAIAKKEGRDPNHIKIILAICVIVAATDEEAQAKREEYLKYADYEGAYALFGGWTGVDLSKYSDTENFLVADSPRVQSLIRRWAASVPGTEGQPWTKKTIAEYLSVGGLQAKLIGSPTTVADQIEQWVDLTDVDGFNVIHITNPGCFEDMAEYLIPELRRRGRFRSHVEKEGATAREVFIGSRRLPEDHPGSKYKWRAGESIPSYQKEEQTSSLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRV8</accession>
    <name>B8MRV8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Starter acyltransferase (SAT) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_057810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487403.1">
        <property type="nucleotide sequence ID" value="XM_002487358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRV8"/>
    <dbReference type="STRING" id="441959.B8MRV8"/>
    <dbReference type="GeneID" id="8108917"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_057810"/>
    <dbReference type="HOGENOM" id="CLU_2238414_0_0_1"/>
    <dbReference type="InParanoid" id="B8MRV8"/>
    <dbReference type="OrthoDB" id="4953895at2759"/>
    <dbReference type="PhylomeDB" id="B8MRV8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Starter acyltransferase (SAT)" evidence="1">
        <location>
            <begin position="5"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="105" mass="11720" checksum="FEF8749C60C1C1AF" modified="2009-03-03" version="1">MVPGSASTEAVRKFGESVSVPFRPYISANASNGITVSGLPLALTKLIQSEMFCGLRHKKIPIYGPYHAIHLYSEFYIDRIVDDLATISTEQRVLVFSETWTKEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRX2</accession>
    <name>B8MRX2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_057950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487417.1">
        <property type="nucleotide sequence ID" value="XM_002487372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRX2"/>
    <dbReference type="STRING" id="441959.B8MRX2"/>
    <dbReference type="GeneID" id="8108931"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_057950"/>
    <dbReference type="HOGENOM" id="CLU_075889_0_0_1"/>
    <dbReference type="InParanoid" id="B8MRX2"/>
    <dbReference type="OMA" id="WAAENIC"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="PhylomeDB" id="B8MRX2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051637">
        <property type="entry name" value="Ank_repeat_dom-contain_49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180:SF45">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED13306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="318" mass="35676" checksum="C06E46552C637549" modified="2009-03-03" version="1">MTDLEKYEQLFDENPMEGSSPLRLIIESNDVATLHSYIKKYPERVFIREAMAYYNPLFVATADDRLDVLRVLLDLADSNGVQLQLDGPWDTSLLDVACEGAQLHTVKFFALLSVAYSLRSDLCYSPDPSTGGRKIWLQDEIARSEEILCMLLDRGASVRDAVRSYKFPDVEQDEKPMSLTATALGRAVSRASYKLASRLIAEGADVHARQYGWGGHPVTAVREVTALHVASGYWNVQGIKALLDNCGEVKPADMVSMRDTAGRIPLHWAAENICFDDYYLTDDEIASQICDTLELLIQRIRKRSTSKTKMVQLPYSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MS18</accession>
    <name>B8MS18_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DsRNA-specific ribonuclease III, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_001340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487717.1">
        <property type="nucleotide sequence ID" value="XM_002487672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MS18"/>
    <dbReference type="STRING" id="441959.B8MS18"/>
    <dbReference type="GeneID" id="8098628"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_001340"/>
    <dbReference type="eggNOG" id="ENOG502SSJ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000907_3_2_1"/>
    <dbReference type="InParanoid" id="B8MS18"/>
    <dbReference type="OMA" id="NPRAHGN"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="PhylomeDB" id="B8MS18"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="31"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="129" mass="14533" checksum="EC90944A2E2D40DB" modified="2009-03-03" version="1">MDCDGLERIIDYTFKDRNLLNEALHQTQNKRLALLGDKVVALMLIDSWYQTGGSCYDGNSLLQHAASNEAMANRAIQTHLKDMVRRQSHQSPSTHGLATDFEAVVGAVWIDCGKDLQTLEKVIRQLYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MS25</accession>
    <name>B8MS25_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitotic spindle checkpoint protein (Mad2), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_002690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487857.1">
        <property type="nucleotide sequence ID" value="XM_002487812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MS25"/>
    <dbReference type="FunCoup" id="B8MS25">
        <property type="interactions" value="1054"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MS25"/>
    <dbReference type="GeneID" id="8102880"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_002690"/>
    <dbReference type="eggNOG" id="KOG3285">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072097_0_0_1"/>
    <dbReference type="InParanoid" id="B8MS25"/>
    <dbReference type="OMA" id="WQFDVEI"/>
    <dbReference type="OrthoDB" id="1806at2759"/>
    <dbReference type="PhylomeDB" id="B8MS25"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033597">
        <property type="term" value="C:mitotic checkpoint complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990498">
        <property type="term" value="C:mitotic spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905318">
        <property type="term" value="P:meiosis I spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.900.10:FF:000002">
        <property type="entry name" value="Mitotic spindle assembly checkpoint protein MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF11">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="7">
        <location>
            <begin position="16"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED12203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="223" mass="24968" checksum="EF58B40ED594CED7" modified="2009-03-03" version="1">MSADKEKSKVHKLSLKGSSKLVAEFFEYSINSILYQRGVYPAEDFSPVKKYGLNMLVSSDDQVRAYIKKIMSQLNKWMIGGKISKLVVVITSKETGEHVERWQFDVQIFKQAASARKTGGITSTTDKENAAADEPTQEKTEAQIQQEIQAIFRQITASVTFLPVLDGNCTFNVLVYADADSDVPVEWGDSDAKEITNGEKVQLRSFSTNNHRVDTLVSYRLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSB9</accession>
    <name>B8MSB9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_000490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED11972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487626.1">
        <property type="nucleotide sequence ID" value="XM_002487581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSB9"/>
    <dbReference type="GeneID" id="8108672"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_000490"/>
    <dbReference type="eggNOG" id="ENOG502S0H3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_26_0_1"/>
    <dbReference type="InParanoid" id="B8MSB9"/>
    <dbReference type="OrthoDB" id="3561817at2759"/>
    <dbReference type="PhylomeDB" id="B8MSB9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="41965" checksum="DAE41193252992B9" modified="2009-03-03" version="1">MAQKPGGQDILALDLPRFQTEAVLPVFRTTPKPVLYRESGFSPPEIELDRIALLATVRLRRLDPYHLLRRRAEQIASNSQQISQFARRTLALPNSEQINPLQYAPWHPCEPLSPLLTLIWTWERGLQHRSRSSSSWRSSSNSICLDNLEVAIHLLSPSTGSFQEIFESFRTLVAVWPLRKRLPHTKSGSIQIRWVPGHAKIPENEAADLTTKEGAASIPPAPHKSSYASLKRYAKTQSLSAAQSQWEKVAPQSYQDLEITTSPKRPGELQLNRLDLGHVIAARTGHGDFADYHKHFNHNDAYLLCQCGARKAPLHFFFCHIAKRRAPWPPGPPSEVISFLLGTAKGAQKLATWLAETYFFEDICPRQPLLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSG4</accession>
    <name>B8MSG4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_000370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED11959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487613.1">
        <property type="nucleotide sequence ID" value="XM_002487568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSG4"/>
    <dbReference type="GeneID" id="8108660"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_000370"/>
    <dbReference type="HOGENOM" id="CLU_066074_0_0_1"/>
    <dbReference type="InParanoid" id="B8MSG4"/>
    <dbReference type="OrthoDB" id="3787051at2759"/>
    <dbReference type="PhylomeDB" id="B8MSG4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="359" mass="41246" checksum="D2EB6578B7D424D9" modified="2009-03-03" version="1">MVPSIEEEDKGIHKETPSKVPNQVIQDHVQLLLRLVQDISRFTSETGANTIPVMTPSHSQVKISVIPTSSVPLQARSLDLYIKVLPNEYGRQPVDSQLAMKFTKAWDKTKNYSGELYNILDDKVRIFLQLCWLTEIQLSQCWAVFPEMLSGRAETYYMHHVNPDASFAQMYWAIKSYFDTESNHTLYYQDWTSITLVDVRCENTGKTLPEAVEILVEKLHLCQHALRPHYMSPKHLISAIIRACQGSLEISEVLSEPTTKFETLVSRLCTRAAIIQKKEAANCQSYNHSEKEQSEAREQFDRYRYAEGKANALDKTYRVFLMDFEAGYNIILDSEDEEEANNNDKDKAIAYFIVGQLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSN5</accession>
    <name>B8MSN5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal lysine N-methyltransferase 4</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_005100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates 60S ribosomal protein L42.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488126.1">
        <property type="nucleotide sequence ID" value="XM_002488081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSN5"/>
    <dbReference type="FunCoup" id="B8MSN5">
        <property type="interactions" value="283"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MSN5"/>
    <dbReference type="GeneID" id="8104494"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_005100"/>
    <dbReference type="eggNOG" id="KOG1338">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017135_0_0_1"/>
    <dbReference type="InParanoid" id="B8MSN5"/>
    <dbReference type="OMA" id="RVDWWLE"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="PhylomeDB" id="B8MSN5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1410.10:FF:000007">
        <property type="entry name" value="Ribosomal lysine N-methyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011383">
        <property type="entry name" value="N-lys_methylase_SETD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015353">
        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF34">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011771">
        <property type="entry name" value="RMS1_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="6">
        <location>
            <begin position="34"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED12472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="480" mass="54127" checksum="3370DB55984B3E9E" modified="2009-03-03" version="1">MSSTEHFPDADDFQRQTDGFMQWLSQQTGVTISSKIEVQDLHHQGSGRGVVARSDIQEGEDLFHLPQRVVLMVKTSPLNEILADELKNLGPWLSLVVVMIYEYSLGERSNWNQYFQVLPTKFDTLMFWSGEELSQLQASAVIHKIGKKDAEEDIFEKIIPLVRSHPDLFPPVNGVMSYDDDAGAQALLELAHRMGSLIMAYAFDIEKGEEEESEGEDGYLTDDEEQLPKGMVPLADLLNADADRNNARLFQEDGALVMRAIKPIKTGDEIFNDYGELPRSDLLRRYGYVTDNYAQYDVVELPLTGICHAAGLDNIESQEYPHLKLLHELEILEDGYCILRPSAEDSLTDILPDELLALLKSLTLEREELQRLQSKQKPPKPILAAREARILLDSVKSKLSQYGTTVEQDKAILQQFASTSSLSTSERRRKMAVEVRLGEKEILQHVSVMLQDFLTAEEKGAGKRTTDGTGQKHQKKAKHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSY9</accession>
    <name>B8MSY9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Monocarboxylate transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_002120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
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    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
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        <property type="entry name" value="MFS_dom"/>
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        <property type="entry name" value="MFS_trans_sf"/>
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        <property type="entry name" value="Proton-linked_MCT"/>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
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    </dbReference>
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    </dbReference>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="176"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="401"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
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        <location>
            <begin position="1"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED12145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="410" mass="44004" checksum="7F0AB1907A90E062" modified="2009-03-03" version="1">MSTEDLPMKEDMESKINKYSEPEQVQTGPKEKEAWVLADPAPDGGFSAWSVLSGSCTIAWIPSLQIFFMFAMGPIVGQLYDRYGPRYLLLVGSLLHVFGLMMASISTQYYQVLLSQGVVSAIGVATIFQPALGVIPGWFDKMRGVAYGITATGSSIGGIIFPIMVQKLIAQVGYGWAMRIAAFMILGLLAIANLAIRSRIPPRPKPMTKEELLQPFQELTMILVIAGFVLLTFGIFIPIDYVVAEALELGMDPNIAQYLLAMLNAGSLFGRLIAGALADTLGAYNIFTFVCYLSGILVLALWIPGTGNAAVIAFAVIFGFTSGAYASLIANLIVKISPNFKVIGYRTGLAFLFGSIGGLTTNPIAGAILQNSNGSYIGMKIFSGVFIMSGTTLVFAARLHRTGPKLVAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTQ2</accession>
    <name>B8MTQ2_TALSN</name>
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        <submittedName>
            <fullName evidence="11">C2H2 transcription factor (Azf1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_005680</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12537.1"/>
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        <property type="nucleotide sequence ID" value="XM_002488146.1"/>
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    <dbReference type="STRING" id="441959.B8MTQ2"/>
    <dbReference type="GeneID" id="8105542"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_005680"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_028814_1_2_1"/>
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    <dbReference type="OrthoDB" id="427030at2759"/>
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    <dbReference type="Proteomes" id="UP000001745">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Transcriptional repressor protein YY1"/>
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        <property type="entry name" value="zinc finger protein 200"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zinc_finger"/>
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        <property type="entry name" value="Znf_C2H2_sf"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="334"/>
            <end position="363"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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            <end position="421"/>
        </location>
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        <location>
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            <end position="448"/>
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        </location>
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        </location>
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        </location>
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        <location>
            <begin position="503"/>
            <end position="565"/>
        </location>
    </feature>
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        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
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        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="276"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="518"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED12537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="606" mass="66764" checksum="14796EFCD53E0C05" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MU15</accession>
    <name>B8MU15_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Triacylglycerol lipase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_006670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488302.1">
        <property type="nucleotide sequence ID" value="XM_002488257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MU15"/>
    <dbReference type="FunCoup" id="B8MU15">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MU15"/>
    <dbReference type="GeneID" id="8105352"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_006670"/>
    <dbReference type="eggNOG" id="ENOG502QQNH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015737_0_0_1"/>
    <dbReference type="InParanoid" id="B8MU15"/>
    <dbReference type="OMA" id="WGDYKGT"/>
    <dbReference type="OrthoDB" id="5592486at2759"/>
    <dbReference type="PhylomeDB" id="B8MU15"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED12648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="323" mass="36237" checksum="90844A223074C077" modified="2009-03-03" version="1">MRAAYNPARLSTALRLSVRTFSTSYPKHVRGDKTDPRFSSLGQLIEDKFAHIQEDYERPKNAIVLAHGLLGFAELKLAGDLLPPIEYWHGIKNALNMKGIKVITTTVPPYGSIEKRAEALVEDIAAEANGQDVNIIAGLDSRYMVSRLRPTEFKVRSLTTIATPHRGSVIADHFMERVDAHVTRLRKLSKSVDRITSEAQAFNQLTRKYLADEFNPNVPDVEDVRYFSYGAMFQPGLFNIFRPFHRILEEVEGPNDGLVSVASSKWGGDSGYKGTLVGVSHLDLINWSNRIQWMLGELTGNKRKFNAIAFYLDIADMLAKEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8MV22</accession>
    <name>B8MV22_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_110910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488668.1">
        <property type="nucleotide sequence ID" value="XM_002488623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MV22"/>
    <dbReference type="GeneID" id="8110120"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_110910"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_614201_0_0_1"/>
    <dbReference type="InParanoid" id="B8MV22"/>
    <dbReference type="OrthoDB" id="5427766at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="446" mass="51240" checksum="67369919A50BDF14" modified="2009-03-03" version="1">MDDITEETLERILRLHSFLILPAFQKRSKPGFTEALTAILTRRGLAVDPEKLNGCEFYGPLDWVTGQHLTSFEIKDIARIINFPLPAQRKRPETAAQAVPEVPTQAGTKTEGTTVIESTTLSSTLTPITMSEPTPVPGWITSIFQTNIQPHISYSKTQYKRDVVYILTLLRRISEEQQTQFAGLIRETDYTQARALAACMDTAKYEEFLAIARDAINSSGYPANNIETFRLFMERFRAGPSERAPTEIDIANGQPGTDTGNYPEERRGQLEAIESREPSGRQESSSSGQSHQNTMQESLTECIFQLEQRFKKSSFEARQEADKLKFRFAKEKDLPLREYVERKVILLQEANIKEEDEIVTRVWENLDPVIMNTIRQEDLSLDEFTRRLFLREVPARLAWNQLNRFAPTHTSPRAYPKSKYKDDKPERQKDKQTEKDTKKEIPSKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8MV82</accession>
    <name>B8MV82_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_008340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962662">
        <property type="protein sequence ID" value="EED11538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488719.1">
        <property type="nucleotide sequence ID" value="XM_002488674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MV82"/>
    <dbReference type="GeneID" id="8110167"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_008340"/>
    <dbReference type="HOGENOM" id="CLU_1620187_0_0_1"/>
    <dbReference type="InParanoid" id="B8MV82"/>
    <dbReference type="OrthoDB" id="4325529at2759"/>
    <dbReference type="PhylomeDB" id="B8MV82"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="164" mass="18251" checksum="A28DA17645E9FC70" modified="2009-03-03" version="1">MGFMEGGRYLPGDYVDEGKLLLFIKEKVASRPPRRGQSLKAERKRKRTAAAAELLSEGPPPKRKREKNSVPSAAFEELLVESDNDETCSEPVPMYNTVRSYCSAINELWAYQTSLGLHNAAHRLPKASTNADVMGSQTVGWLRYEMGTLPLRLLILQERSGPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8LT04</accession>
    <name>B8LT04_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyglutamate biosynthesis protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_064660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CapA family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340387.1">
        <property type="nucleotide sequence ID" value="XM_002340346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LT04"/>
    <dbReference type="STRING" id="441959.B8LT04"/>
    <dbReference type="GeneID" id="8103960"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_064660"/>
    <dbReference type="eggNOG" id="ENOG502S32D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038823_3_0_1"/>
    <dbReference type="InParanoid" id="B8LT04"/>
    <dbReference type="OMA" id="CGDVMTG"/>
    <dbReference type="OrthoDB" id="189619at2759"/>
    <dbReference type="PhylomeDB" id="B8LT04"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07381">
        <property type="entry name" value="MPP_CapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019079">
        <property type="entry name" value="Capsule_synth_CapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052169">
        <property type="entry name" value="CW_Biosynth-Accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33393">
        <property type="entry name" value="POLYGLUTAMINE SYNTHESIS ACCESSORY PROTEIN RV0574C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33393:SF11">
        <property type="entry name" value="POLYGLUTAMINE SYNTHESIS ACCESSORY PROTEIN RV0574C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00854">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Capsule synthesis protein CapA" evidence="2">
        <location>
            <begin position="6"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED23000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="409" mass="46209" checksum="756F171B69377FE6" modified="2009-03-03" version="1">MAKEYALNFTGDVMLGRLIDQLYLTHVSNPEDQKHIRVFQARHASRLGFGKYTVSSPWGTVLPLLADEGDLNLINLETSITTHPTPWPDKTFNYRMHPANAVPILAAAKIDFACLANNHTLDFVWTLKHSSSPEQQHRIAIAGAGESTQEAVSPAILELPRSKSQHGVKHGGRPGALSSKDLEERKGKHLIHVYAATDHPRAWSDVPTFHFVDYSEKSREHLRRITSRYSTPVSGSEEASLKILSVHWGPNYRWHPAREIRSMAHFLIFECGIDIIHGHSSHHVQGIECPAPGKLIIYGCGDFVDDYALNKEFRNDLGALYRVIVKEEMGAKKVKPVRLEIFPTKITHFQAYLLRHKGDKDHDWVVDTITRLTNELMRSECDCGYAHDTKKNIFRPSLGDRGQLIIDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8LT05</accession>
    <name>B8LT05_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular OTU-like cysteine protease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_064670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340388.1">
        <property type="nucleotide sequence ID" value="XM_002340347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LT05"/>
    <dbReference type="STRING" id="441959.B8LT05"/>
    <dbReference type="GeneID" id="8102389"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_064670"/>
    <dbReference type="eggNOG" id="ENOG502QUTD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046150_0_0_1"/>
    <dbReference type="InParanoid" id="B8LT05"/>
    <dbReference type="OMA" id="IHIAFHD"/>
    <dbReference type="OrthoDB" id="409956at2759"/>
    <dbReference type="PhylomeDB" id="B8LT05"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22756">
        <property type="entry name" value="OTU_OTUD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF7">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="68"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED23001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="497" mass="54912" checksum="A9A2A5FD9CD909EE" modified="2009-03-03" version="1">MAESPANRSRIVPIMADEALSKPKSTTRKSAPIPRPAAPSRISTRSRTKSYGLDGVDGNLKILEERGLYVAKTPGDGNCLFYALSDQMYGTMERAFEIREALAVHMSTHEEYFGAFAVPEESERRSARVAARRTESPFPATPSPTVNDKQDAFTDMVSRCATPAVWGGGVEIQAFCQYYQRDVRVYSPDNVQNFRAWDAPNDEVREVVHLAYINGVHYSSVRNIDGPHEGLPNVKPKAVVIDIESPQAWKISHIQNGLSGQYDQDTIVSMLRRCRGDINRAFARLLDEESSSTSSFVSSATSAASSQATTASTPEQQQNANELRNETTATPMVNFKPHLMSSRSSSRHSTASKRSADDSDDEGSVLSAQRGREQKRRILPKVTVGINFGDHDQPDMVSLRWRVDSDVVAEQVTATPSSLKQSEQPKSELEQPKPTSEQDKPNAKPKKTQTKAKVKPKSRAEQGQCRKLRPRKPRSSVTSELDTALTLSDESSVKLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTM3</accession>
    <name>B8LTM3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_070280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341002.1">
        <property type="nucleotide sequence ID" value="XM_002340961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTM3"/>
    <dbReference type="GeneID" id="8107306"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_070280"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016400_0_0_1"/>
    <dbReference type="InParanoid" id="B8LTM3"/>
    <dbReference type="OrthoDB" id="4226988at2759"/>
    <dbReference type="PhylomeDB" id="B8LTM3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="548" mass="59755" checksum="2ECAB472DA3D322E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTP3</accession>
    <name>B8LTP3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxidoreductase, short-chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_070450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341021.1">
        <property type="nucleotide sequence ID" value="XM_002340980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTP3"/>
    <dbReference type="STRING" id="441959.B8LTP3"/>
    <dbReference type="GeneID" id="8108474"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_070450"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8LTP3"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="PhylomeDB" id="B8LTP3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF26">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_4G05870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED23634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="319" mass="34728" checksum="727DDA89F9BD9D79" modified="2009-03-03" version="1">MTDKSQFEFGHQIPVHHQDRPGFQHKIPDPKPVSDKLPTEDGGYQLYKAAGKLQGKRAVITGGDSGIGRAVAILYAMEGASSLIAYLDSEEKDAQETKKEVEKYGAKCFLFPTDLRKRENCKAVIDKAVEQLGGIDILVNNAAFQKMLPDIKDLSEEQWLNTFNTNIHPYFFLAKYALPHLKRGSTIINCASVNPYVGRGDLLDYTSSKGAIVAFTRALSNQQVGKGIRVNAVCPGPSMHNPLPPILIIVALLTFTLVWTPLIPSTMTTEAMEQFSGVPMGRPGQPSEVATCFVFLASQDSSYMSGQSLHPNGGVVVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8LU26</accession>
    <name>B8LU26_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_072490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS26 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341243.1">
        <property type="nucleotide sequence ID" value="XM_002341202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LU26"/>
    <dbReference type="FunCoup" id="B8LU26">
        <property type="interactions" value="770"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LU26"/>
    <dbReference type="GeneID" id="8104256"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_072490"/>
    <dbReference type="eggNOG" id="KOG1768">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129451_1_0_1"/>
    <dbReference type="InParanoid" id="B8LU26"/>
    <dbReference type="OMA" id="KCYCVSC"/>
    <dbReference type="OrthoDB" id="10262653at2759"/>
    <dbReference type="PhylomeDB" id="B8LU26"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1740.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.20">
        <property type="entry name" value="Ribosomal protein S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000892">
        <property type="entry name" value="Ribosomal_eS26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047864">
        <property type="entry name" value="Ribosomal_eS26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038551">
        <property type="entry name" value="Ribosomal_eS26_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01283">
        <property type="entry name" value="Ribosomal_S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00733">
        <property type="entry name" value="RIBOSOMAL_S26E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED23856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="119" mass="13530" checksum="7C31E43036F15694" modified="2009-03-03" version="1">MVKKRASNGRNKKGRGHVKPIRCSNCSRCTPKDKAIKRFTIRNMVESAAIRDISDASVFTDYAVPKMYLKLQYCVSCAIHGKIVRVRSREGRRNRAPPPRIRYNKDGKKLNPQQAAKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUB5</accession>
    <name>B8LUB5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ras guanine-nucleotide exchange protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_070930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341075.1">
        <property type="nucleotide sequence ID" value="XM_002341034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUB5"/>
    <dbReference type="STRING" id="441959.B8LUB5"/>
    <dbReference type="GeneID" id="8102019"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_070930"/>
    <dbReference type="eggNOG" id="KOG3417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002116_1_0_1"/>
    <dbReference type="InParanoid" id="B8LUB5"/>
    <dbReference type="OMA" id="EEVWERD"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="PhylomeDB" id="B8LUB5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF354">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="67"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="8">
        <location>
            <begin position="685"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="7">
        <location>
            <begin position="865"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="518"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="625"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="549"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="630"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED23688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1148" mass="127341" checksum="D511372D4D082900" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUG0</accession>
    <name>B8LUG0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_071320</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341120.1">
        <property type="nucleotide sequence ID" value="XM_002341079.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341121.1">
        <property type="nucleotide sequence ID" value="XM_002341080.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341122.1">
        <property type="nucleotide sequence ID" value="XM_002341081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUG0"/>
    <dbReference type="FunCoup" id="B8LUG0">
        <property type="interactions" value="671"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LUG0"/>
    <dbReference type="GeneID" id="8105130"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_071320"/>
    <dbReference type="eggNOG" id="KOG0975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031922_0_0_1"/>
    <dbReference type="InParanoid" id="B8LUG0"/>
    <dbReference type="OMA" id="LTEVFAC"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000005">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED23733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="414" mass="46123" checksum="2386B64BC712076D" modified="2009-03-03" version="1">MRLSNQLMRNTLLRTSKTRYTASSLSSSLWKRSYSIKPISASTELPALDPSKLEITKTTTPKDLTPNSQLQFGKTFTDHMLTMEWTATDGWLTPRIVPYQNLSLDPATCVFHYAFECFEGMKAYKDKDGKIRLFRPDKNMERLNKSSARIALPTFNGDSLTKLIAEFTKLESRFIPNEKGYSLYLRPTMIGTQKTIGVGPPGSALLFVIASPVGPYYPTGFKAVSLEATDYAVRAWPGGVGDKKLGANYAPCIVPQQEAASRGFQQNLWLFGEEEYVTEVGTMNLFMAIKNKETGLKELLTAPLDGTILEGVTRDTVLALARERLVPEGWVVSERKVRMSEVAEAATEGRLLEVFGSGTAAIVSPVRKISYKGQLVDCGLQENEEAGEIALRMKNWIEGIQYGEEKHPWSYVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUN8</accession>
    <name>B8LUN8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CST complex subunit Ten1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_072850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341282.1">
        <property type="nucleotide sequence ID" value="XM_002341241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUN8"/>
    <dbReference type="GeneID" id="8099992"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_072850"/>
    <dbReference type="eggNOG" id="ENOG502SESG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102601_1_0_1"/>
    <dbReference type="InParanoid" id="B8LUN8"/>
    <dbReference type="OMA" id="GCVTHYT"/>
    <dbReference type="OrthoDB" id="5275361at2759"/>
    <dbReference type="PhylomeDB" id="B8LUN8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990879">
        <property type="term" value="C:CST complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024222">
        <property type="entry name" value="Ten1_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12658">
        <property type="entry name" value="Ten1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED23895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="17153" checksum="1A8CCAE69B64B8A4" modified="2009-03-03" version="1">MNGPIPTRLVFLHELSSLPPHTKVRFLGCVTRYDTVRGRLELEHNFPPLSRKDKKRSSSIASRRVSVDICHVLNTITGGQLQVGTWLNIFGYIRLEMQSKKDEDCHTPEDANGSQIYVEAVMISDAGALRVAEYEQSLADMQAINRRLGRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVJ2</accession>
    <name>B8LVJ2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA ligase</fullName>
            <ecNumber evidence="1">6.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_073960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + (ribonucleotide)n-3'-hydroxyl + 5'-phospho-(ribonucleotide)m = (ribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRL1 family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.3" evidence="1"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341398.1">
        <property type="nucleotide sequence ID" value="XM_002341357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVJ2"/>
    <dbReference type="FunCoup" id="B8LVJ2">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LVJ2"/>
    <dbReference type="GeneID" id="8102628"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_073960"/>
    <dbReference type="eggNOG" id="ENOG502QQB9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010316_1_0_1"/>
    <dbReference type="InParanoid" id="B8LVJ2"/>
    <dbReference type="OMA" id="FQDWDYK"/>
    <dbReference type="OrthoDB" id="276239at2759"/>
    <dbReference type="PhylomeDB" id="B8LVJ2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051730">
        <property type="term" value="F:GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001690">
        <property type="entry name" value="tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019039">
        <property type="entry name" value="T4-Rnl1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012387">
        <property type="entry name" value="Trl1_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015966">
        <property type="entry name" value="tRNA_lig_kin_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015965">
        <property type="entry name" value="tRNA_lig_PDEase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004:SF1">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09511">
        <property type="entry name" value="RNA_lig_T4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08302">
        <property type="entry name" value="tRNA_lig_CPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08303">
        <property type="entry name" value="tRNA_lig_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019634">
        <property type="entry name" value="tRNA_lig_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="T4 RNA ligase 1-like N-terminal" evidence="5">
        <location>
            <begin position="66"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase kinase" evidence="4">
        <location>
            <begin position="389"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase phosphodiesterase" evidence="3">
        <location>
            <begin position="553"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="2">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR019634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR019634-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED24011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="838" mass="95194" checksum="F274E062D053D9C1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVP5</accession>
    <name>B8LVP5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_075470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341562.1">
        <property type="nucleotide sequence ID" value="XM_002341521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVP5"/>
    <dbReference type="STRING" id="441959.B8LVP5"/>
    <dbReference type="GeneID" id="8106232"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_075470"/>
    <dbReference type="eggNOG" id="ENOG502SS49">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075342_0_0_1"/>
    <dbReference type="InParanoid" id="B8LVP5"/>
    <dbReference type="OMA" id="IDMIASP"/>
    <dbReference type="OrthoDB" id="2245989at2759"/>
    <dbReference type="PhylomeDB" id="B8LVP5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF9">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED24175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="34535" checksum="3ABE3FD1C390C99A" modified="2009-03-03" version="1">MSDSGDSSKAEKKREYNRNAQRLFRQRRKEHLKSLERADKERSSSHAEELQRLREDIEQLRAENRALKSCSKISSPHASSVPSSVVMPGSPSPYPTSPFRSLELYDSAHGSDDLVRSPSEIQGEELYQERHEYRARGHRSRQTTGPDSFCALFPQDISLVRRNLHLQLAPVLDLHIISNPQLHLSTLAAIGPSLPPALQPTLLQLQTPHHAYIDLIPSPNLRDALIQAGFAVANSFLTEVCTFVYETEDLGQLTIWGRDYLNVMSWEFSEGVLKAWPNLLTAEWRERANFWRAQRSEPLIIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVP9</accession>
    <name>B8LVP9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Period circadian protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_075510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341566.1">
        <property type="nucleotide sequence ID" value="XM_002341525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVP9"/>
    <dbReference type="GeneID" id="8106163"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_075510"/>
    <dbReference type="eggNOG" id="ENOG502RGAR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1603294_0_0_1"/>
    <dbReference type="InParanoid" id="B8LVP9"/>
    <dbReference type="OMA" id="QTSYLAM"/>
    <dbReference type="OrthoDB" id="5429002at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002874507" evidence="2">
        <location>
            <begin position="17"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED24179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="185" mass="17341" checksum="B0F0B494CA9711D0" modified="2009-03-03" version="1">MRSIIAAAAFATVAIAQSADTSVTPVSVSNPATQYLTMTNSLGVVTGQPSVVTSQPEAATSQPPAASIPAGLTSPVVPLSPTTTDTSAAPSGSSATGSGTATGTVTGATTGTTTGTTTGTTTGTTTGKVTSSGFSTATTSESSTHTSGTSSSSASSTHATGAAAMATAGPMGLSLVAGAAFAMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVV3</accession>
    <name>B8LVV3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_076840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341706.1">
        <property type="nucleotide sequence ID" value="XM_002341665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVV3"/>
    <dbReference type="GeneID" id="8106022"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_076840"/>
    <dbReference type="eggNOG" id="ENOG502RNUN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039210_0_0_1"/>
    <dbReference type="InParanoid" id="B8LVV3"/>
    <dbReference type="OrthoDB" id="4224912at2759"/>
    <dbReference type="PhylomeDB" id="B8LVV3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED24319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="382" mass="43109" checksum="C72E3C856085741F" modified="2009-03-03" version="1">MPSMCFTPPAKQLSSTGGHMNQIHGNRDRLIEDIRVCGQFLNGLDALSGEMASNSTLLSFVEACERVVVALGREQRIQSQEGRAIQGLIRKDWRLSSGEIPGTTPSVPRKHVAASHATILEHTLLDYGKDHSELKYRREEICEDKVCAVENLHDICKVQKIDPNMAQTCKMCFPEKNTQLINAHCQAKWKREQKAFYVVSFVLIGITLISGLILYIRRRYLRAKNPHADENATNETGINPPGELYYYDGPRSILPTERHSSLAVNCSPEPRQNEDSKRYHNSWDDNEDGVISTSAAHRRLKQLGILSRTGRKKIHDLFDLEALQSRRGTIKDSQRRSDEKDRVPVMPWAPNASVRLSSRSSPTVRQATRSKTPSAVELQEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8LW00</accession>
    <name>B8LW00_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin conjugating enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_077320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341753.1">
        <property type="nucleotide sequence ID" value="XM_002341712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LW00"/>
    <dbReference type="STRING" id="441959.B8LW00"/>
    <dbReference type="GeneID" id="8101949"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_077320"/>
    <dbReference type="eggNOG" id="ENOG502T9KG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038857_1_1_1"/>
    <dbReference type="InParanoid" id="B8LW00"/>
    <dbReference type="OMA" id="WSCFRGF"/>
    <dbReference type="OrthoDB" id="2896006at2759"/>
    <dbReference type="PhylomeDB" id="B8LW00"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED24366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="37961" checksum="EC2E1C5E65239A46" modified="2009-03-03" version="1">MSALTSVLIRRGTELISARLQYREQPQTHGLPGFLTVVFTVVAFGLAIFWVDYTCTHVIATLAAVEDSHPTSYIRLEGEDSNDTFNGNNTAKPITSGLRSAINYLRARGGIWSCFRGFRMYLAFTGLDFGAGLLISAIGPIQIAYPIRSLFGGFVTSMLLVTWQMAWIHLVIADKSPRRSFRRMLGLQHWPRIAPAAALYNFLTCVTLSAATASWTAMSLVSSGFKGRLGLLATSIISAVFFLLLSIPARAIFTRVAASMLPEEDEQIVPFDRHFNGKAKPEIVGGSGKLSIRDAWATFEWAARIRYVKIILKAFAIEFALAVVGILLVVGELALLNPSRATPRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWB6</accession>
    <name>B8LWB6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1680 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_075980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341614.1">
        <property type="nucleotide sequence ID" value="XM_002341573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWB6"/>
    <dbReference type="STRING" id="441959.B8LWB6"/>
    <dbReference type="GeneID" id="8102482"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_075980"/>
    <dbReference type="eggNOG" id="ENOG502QYM6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013148_3_0_1"/>
    <dbReference type="InParanoid" id="B8LWB6"/>
    <dbReference type="OMA" id="ANRGENE"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="PhylomeDB" id="B8LWB6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049174">
        <property type="entry name" value="Beta-AFase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049049">
        <property type="entry name" value="Beta-AFase-like_GH127_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Beta-AFase-like_GH127_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049046">
        <property type="entry name" value="Beta-AFase-like_GH127_middle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43465">
        <property type="entry name" value="DUF1680 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G08910)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43465:SF2">
        <property type="entry name" value="DUF1680 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G08910)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Beta-AFase-like_GH127_cat"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Glyco_hydro127C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20736">
        <property type="entry name" value="Glyco_hydro127M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 catalytic" evidence="1">
        <location>
            <begin position="106"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 middle" evidence="2">
        <location>
            <begin position="409"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 C-terminal" evidence="3">
        <location>
            <begin position="497"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED24227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="613" mass="69206" checksum="6AB3655E330DD5BB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWF3</accession>
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        </submittedName>
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        <name evidence="3" type="ORF">TSTA_076320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341651.1">
        <property type="nucleotide sequence ID" value="XM_002341610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWF3"/>
    <dbReference type="STRING" id="441959.B8LWF3"/>
    <dbReference type="GeneID" id="8105660"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_076320"/>
    <dbReference type="eggNOG" id="ENOG502S4VH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042937_1_1_1"/>
    <dbReference type="InParanoid" id="B8LWF3"/>
    <dbReference type="OMA" id="CTQANPE"/>
    <dbReference type="OrthoDB" id="6508832at2759"/>
    <dbReference type="PhylomeDB" id="B8LWF3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="212"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED24264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="263" mass="30879" checksum="F1F3D7C5228A083A" modified="2009-03-03" version="1">MFGITVDSERKGITIENRYEALDTMHAASHRDNEAIHRIKKIVENIGSRTHQQVTEARKPKTLSPQQKKTAENIAFQKQTMYRHPDAEPILSRPRPFVAGQRQIPKLVSARGVPFLRIKKPQPQNLSRIIRYKLRFKDKLVERRERLLIDTLFAKDEEDWDRLIEGQPVTPRVIHAHHPIRWIEGSWMESPLECYKKAFYDNIEFEKKQQELAEKMWEVVLAERKLAAEEEEEAKEARKETEKPPSVGSWISLIQKYGRQLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWV7</accession>
    <name>B8LWV7_TALSN</name>
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        <submittedName>
            <fullName evidence="5">Cell differentiation and development protein Fsr1/Pro11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_079450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002341936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWV7"/>
    <dbReference type="STRING" id="441959.B8LWV7"/>
    <dbReference type="GeneID" id="8107651"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_079450"/>
    <dbReference type="eggNOG" id="KOG0642">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009046_0_0_1"/>
    <dbReference type="InParanoid" id="B8LWV7"/>
    <dbReference type="OMA" id="SKCSQEV"/>
    <dbReference type="OrthoDB" id="727118at2759"/>
    <dbReference type="PhylomeDB" id="B8LWV7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013258">
        <property type="entry name" value="Striatin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF0">
        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="4">
        <location>
            <begin position="36"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="733"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="255"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="561"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="576"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED24590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="812" mass="87726" checksum="BD4DE003675BA20C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8LX48</accession>
    <name>B8LX48_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_061860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LX48"/>
    <dbReference type="STRING" id="441959.B8LX48"/>
    <dbReference type="GeneID" id="8102378"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_061860"/>
    <dbReference type="HOGENOM" id="CLU_1876815_0_0_1"/>
    <dbReference type="InParanoid" id="B8LX48"/>
    <dbReference type="OrthoDB" id="4364447at2759"/>
    <dbReference type="PhylomeDB" id="B8LX48"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="136" mass="15369" checksum="CD25C2186D4DE513" modified="2009-03-03" version="1">MTFLIRRRALKTKSKDKGLSVYGATCSPVNIVSPTQTLPPSDSATTLAGALDTPPSNTSRCKQLNVPGPQDAAVKNYSEWHASKVDDYDLKNDYRKAYQVIFNRPDPNFFIEREVKIGTAHRFVDVDDIMEWAERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXN8</accession>
    <name>B8LXN8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_078960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341926.1">
        <property type="nucleotide sequence ID" value="XM_002341885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXN8"/>
    <dbReference type="GeneID" id="8104234"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_078960"/>
    <dbReference type="HOGENOM" id="CLU_1994128_0_0_1"/>
    <dbReference type="InParanoid" id="B8LXN8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED24539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="125" mass="14312" checksum="4EAFCBF5A55B0C48" modified="2009-03-03" version="1">MNDEFLGTADIQEVTQIKHLLVEKQTELLSIEWREGIATLEIEDSDILSDDSLDQIFMDYDKNDSEDSIEMVISEQGTVYSINEESLPLRRVEVKDFSYGLIGLWLLLICFSIAKTLEKTGQSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8LY77</accession>
    <name>B8LY77_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Catabolite repressor protein (CreC), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_067570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Required to prevent the proteolysis of the CreB deubiquitinating enzyme in the absence of carbon catabolite repression. CreB deubiquitinating enzyme stabilized in a complex with the CreC leads to the expression of genes such as those in the proline and quinate pathways.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with creB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat creC family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340709.1">
        <property type="nucleotide sequence ID" value="XM_002340668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LY77"/>
    <dbReference type="STRING" id="441959.B8LY77"/>
    <dbReference type="GeneID" id="8106187"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_067570"/>
    <dbReference type="eggNOG" id="KOG2394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016971_1_1_1"/>
    <dbReference type="InParanoid" id="B8LY77"/>
    <dbReference type="OMA" id="MCVCWSP"/>
    <dbReference type="OrthoDB" id="3367at2759"/>
    <dbReference type="PhylomeDB" id="B8LY77"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045013">
        <property type="term" value="P:carbon catabolite repression of transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000531">
        <property type="entry name" value="Probable catabolite repression protein creC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF16">
        <property type="entry name" value="AT02583P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="364"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="467"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="554"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED23322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="581" mass="64066" checksum="24513DCFB4F12867" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYB7</accession>
    <name>B8LYB7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_063280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340233.1">
        <property type="nucleotide sequence ID" value="XM_002340192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYB7"/>
    <dbReference type="STRING" id="441959.B8LYB7"/>
    <dbReference type="GeneID" id="8099987"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_063280"/>
    <dbReference type="eggNOG" id="ENOG502T2QC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1070308_0_0_1"/>
    <dbReference type="InParanoid" id="B8LYB7"/>
    <dbReference type="OrthoDB" id="5355007at2759"/>
    <dbReference type="PhylomeDB" id="B8LYB7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="260" mass="28870" checksum="1BC9613F442D789F" modified="2009-03-03" version="1">MTAGSMWCEPEKEKSQLSPPVHFLVHLQLGRDSARRHNRTGPFSPRFLHSLQASLRTIKKTQDEQGVCRRKDHITSIPIMPSETTFSPETVESEIYNHLLSDSSTALDDLHANLLFSLQRAGWTERVQSLSLELLRAGRCTHFDDMVDVVVTLATGQTHPIVPEANNNTTTNGHEKNSSNGTATAANGVNNATSSESFFRDIDVRIPKEVVEQGVRSLKDSLRSFATIEDDDDGGPEVDDKELTNGKASKSEKEQTSQWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZ04</accession>
    <name>B8LZ04_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase/esterase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_069330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340899.1">
        <property type="nucleotide sequence ID" value="XM_002340858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZ04"/>
    <dbReference type="STRING" id="441959.B8LZ04"/>
    <dbReference type="GeneID" id="8103964"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_069330"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_6_3_1"/>
    <dbReference type="InParanoid" id="B8LZ04"/>
    <dbReference type="OMA" id="IPINDGW"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="PhylomeDB" id="B8LZ04"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="74"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED23512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="329" mass="36756" checksum="3FBFE83740C71762" modified="2009-03-03" version="1">MKPLHAEWSSFITQHPKIRHDDHQRNRDFYDSPAGHKFVTEVLTIDTTIPASDDHNIPIRIYTAKRSELSHGVVIFFHSGGFTSGSLETEDVSCRYMALSGPLTVLSVEYRLSPAYTFPVPVNDGWDAFRYIVTNLSSLVANLAPGMVNMVVSGTSSGGQLAAIVSQRAQTWMKGNISCAKITMSGVLLRAPVTVNGTDSHFIPPRLRDIHKSWCAELETTLLKRHEMEENHDALGVPLNERNSPEAYPLWGQFHGLPKVYIQICDVDILRDDAVCYAQSLRDAGVEVQESLYLDLPHIFWIYAHHLDVSKKAQEDCVQGLNWLLASTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZF4</accession>
    <name>B8LZF4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_089440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478670.1">
        <property type="nucleotide sequence ID" value="XM_002478625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZF4"/>
    <dbReference type="STRING" id="441959.B8LZF4"/>
    <dbReference type="GeneID" id="8104911"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_089440"/>
    <dbReference type="eggNOG" id="ENOG502S215">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006512_0_0_1"/>
    <dbReference type="InParanoid" id="B8LZF4"/>
    <dbReference type="OMA" id="YEDLDPW"/>
    <dbReference type="OrthoDB" id="1883964at2759"/>
    <dbReference type="PhylomeDB" id="B8LZF4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="521"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1086"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1125"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="843"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="629"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1141"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1164"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1191"/>
            <end position="1210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED21707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1219" mass="134448" checksum="0E8A3ABFCBFC2400" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZU0</accession>
    <name>B8LZU0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Malonyl CoA-acyl carrier protein transacylase, putative</fullName>
            <ecNumber evidence="19">2.3.1.38</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSTA_081050</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15057"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9924"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78783"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41788"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="EC" id="2.3.1.38"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the fungal fatty acid synthetase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.38" evidence="19"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477835.1">
        <property type="nucleotide sequence ID" value="XM_002477790.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LZU0"/>
    <dbReference type="GeneID" id="8101410"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_081050"/>
    <dbReference type="eggNOG" id="ENOG502QQJX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000114_5_0_1"/>
    <dbReference type="InParanoid" id="B8LZU0"/>
    <dbReference type="OMA" id="ITHGMHM"/>
    <dbReference type="OrthoDB" id="4251012at2759"/>
    <dbReference type="PhylomeDB" id="B8LZU0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004313">
        <property type="term" value="F:[acyl-carrier-protein] S-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:fatty acyl-[ACP] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03447">
        <property type="entry name" value="FAS_MaoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000078">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3330:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="FAS1-like_DH_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016452">
        <property type="entry name" value="Fas1/AflB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013565">
        <property type="entry name" value="Fas1/AflB-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041099">
        <property type="entry name" value="FAS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040883">
        <property type="entry name" value="FAS_meander"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08354">
        <property type="entry name" value="Fas1-AflB-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="FAS1_DH_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22235">
        <property type="entry name" value="FAS1_thioest_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17951">
        <property type="entry name" value="FAS_meander"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17828">
        <property type="entry name" value="FAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005562">
        <property type="entry name" value="FAS_yeast_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="19" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 16" id="KW-0520">NAD</keyword>
    <keyword evidence="5 16" id="KW-0521">NADP</keyword>
    <keyword evidence="6 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="18">
        <location>
            <begin position="1684"/>
            <end position="2017"/>
        </location>
    </feature>
    <feature type="active site" description="For acetyltransferase activity" evidence="17">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <feature type="active site" description="For malonyltransferase activity" evidence="17">
        <location>
            <position position="1828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR005562-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EED20872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="2095" mass="234414" checksum="7032A58BD0D77A2A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8M054</accession>
    <name>B8M054_TALSN</name>
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        <submittedName>
            <fullName evidence="5">Pogo transposable element, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_083830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002478069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M054"/>
    <dbReference type="GeneID" id="8101476"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_083830"/>
    <dbReference type="eggNOG" id="KOG3105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_4_0_1"/>
    <dbReference type="InParanoid" id="B8M054"/>
    <dbReference type="OMA" id="NAQESEY"/>
    <dbReference type="OrthoDB" id="3790270at2759"/>
    <dbReference type="PhylomeDB" id="B8M054"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="60"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED21151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="559" mass="63680" checksum="685F39AB65E4E289" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1D1</accession>
    <name>B8M1D1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_090660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478790.1">
        <property type="nucleotide sequence ID" value="XM_002478745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1D1"/>
    <dbReference type="STRING" id="441959.B8M1D1"/>
    <dbReference type="GeneID" id="8101557"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_090660"/>
    <dbReference type="eggNOG" id="ENOG502S9CJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014758_0_0_1"/>
    <dbReference type="InParanoid" id="B8M1D1"/>
    <dbReference type="OMA" id="CRPETSF"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="PhylomeDB" id="B8M1D1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="544" mass="62479" checksum="D61C43C56B7299A6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B8M273</accession>
    <name>B8M273_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G-protein complex alpha subunit GpaA/FadA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_087730</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(q) subfamily.</text>
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        <property type="protein sequence ID" value="EED21537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002478455.1"/>
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    <dbReference type="AlphaFoldDB" id="B8M273"/>
    <dbReference type="STRING" id="441959.B8M273"/>
    <dbReference type="GeneID" id="8100902"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_087730"/>
    <dbReference type="eggNOG" id="KOG0082">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014184_6_0_1"/>
    <dbReference type="InParanoid" id="B8M273"/>
    <dbReference type="OMA" id="QVIWADA"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="PhylomeDB" id="B8M273"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000001">
        <property type="entry name" value="Guanine nucleotide-binding protein G(I) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000051">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="28"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="135"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="160"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="185"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="254"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED21537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="338" mass="39055" checksum="4BB478D9E2F8FE25" modified="2009-03-03" version="1">MGCGMSTEDKEGKARNEEIENQLKRAGESGKSTILKQMKLINEGGYSRDERESFKEIIYSNTVQSMRVILEAMESLELPLEDPRAEYHVQTIFMQPSQIEGDSLPPEVGNAIQALWRDAGVQECFRRSREYQLNDSAKYYFDSIERIAQPDYLPSDQDVLRSRVKTTGITETTFIIGDLTYRMFDVGGQRSERKKWIHCFENVTTILFLVAISEYDQLLFEDETVNRMQEALTLFDSICNSRWFIKTSIILFLNKIDRFKEKLPVSPMKNYFPDYEGGADYAAACDYILNRFVSLNQAEQKQIYTHFTCATDTNQIRFVMAAVNDIIIQENLRLCGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8M479</accession>
    <name>B8M479_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_040160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481256.1">
        <property type="nucleotide sequence ID" value="XM_002481211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M479"/>
    <dbReference type="STRING" id="441959.B8M479"/>
    <dbReference type="GeneID" id="8109775"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_040160"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002055_1_1_1"/>
    <dbReference type="InParanoid" id="B8M479"/>
    <dbReference type="OMA" id="LMIDMIC"/>
    <dbReference type="OrthoDB" id="4368291at2759"/>
    <dbReference type="PhylomeDB" id="B8M479"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED20822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="40509" checksum="54B9AF74BA3799C5" modified="2009-03-03" version="1">MKQLAMETSTYDPCLLHYRDPKQGFGIIGMQTDDTLIVADEAFAIREEEQIKRANILCKPREQLITSKPLRFNGAVITEDAQDHPSDIVNSRGKIRKNASLYEQYVAQRALGAYIASVSQPEASFDLSFAAQATQPDEEDIKALNKRLKWQADNPNHGLRFIKINLRTAQLYAFIDASFANNKDSSSQIGYIIVLADAQNNANILHWSSTKCKRITRSVLASEMYGMANGFDAAAAIKSTLTQLLHLLEPLPLVLCTDSKSLYECLVKLGTTREKRLMIDLMCLRQSYERQEITEVRWINGNSNPADAITKSKPCRALQELIDTNKLRIDVNGWVERSLMKRNSKLKNVRFATPVTTPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4X7</accession>
    <name>B8M4X7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LRP16 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_027120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479846.1">
        <property type="nucleotide sequence ID" value="XM_002479801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4X7"/>
    <dbReference type="STRING" id="441959.B8M4X7"/>
    <dbReference type="GeneID" id="8109631"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_027120"/>
    <dbReference type="eggNOG" id="KOG2633">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046550_10_2_1"/>
    <dbReference type="InParanoid" id="B8M4X7"/>
    <dbReference type="OrthoDB" id="6077599at2759"/>
    <dbReference type="PhylomeDB" id="B8M4X7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02908">
        <property type="entry name" value="Macro_OAADPr_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF27">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="2">
        <location>
            <begin position="29"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="305" mass="33591" checksum="F36719E93D7928C6" modified="2009-03-03" version="1">MASNIVTLAQIPTLTQLYRGRLLSPSQQPGSNSPSKALNDILSHIQYDITRLQVDGIVNAANQWLQGGGGVDGAIHHAAGSQLLAECRTLDGCNTGDAKITNGYNLPAAKVIHAVGPIYEERYHLTLERLLRSCYRRSLQLAVENNLRSVAFSAISTGVYGYPNLEAAQAVLDEVGKFLRKDDNASKFDRIIFCSFMPADVEAYQRFLPFYFPPMPEDIGNANTSPETKADNDTEFVDVNDESFKSVTDDEQDWEELSEGANHHDLDEEPVELNSQAASVTDIQSMQSSSAEFDELSKSETEHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4Z7</accession>
    <name>B8M4Z7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber evidence="2 9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_027290</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 15">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2 9"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479866.1">
        <property type="nucleotide sequence ID" value="XM_002479821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4Z7"/>
    <dbReference type="FunCoup" id="B8M4Z7">
        <property type="interactions" value="803"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M4Z7"/>
    <dbReference type="GeneID" id="8109648"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_027290"/>
    <dbReference type="eggNOG" id="KOG0323">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007683_0_2_1"/>
    <dbReference type="InParanoid" id="B8M4Z7"/>
    <dbReference type="OMA" id="DQTVIHC"/>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="PhylomeDB" id="B8M4Z7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17729">
        <property type="entry name" value="BRCT_CTDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000049">
        <property type="entry name" value="RNA Polymerase II CTD phosphatase Fcp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000142">
        <property type="entry name" value="Similar to FCP1-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
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        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
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        <location>
            <begin position="155"/>
            <end position="331"/>
        </location>
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        <location>
            <begin position="512"/>
            <end position="605"/>
        </location>
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        </location>
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        <location>
            <begin position="408"/>
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        </location>
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        </location>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="RuleBase" id="RU366066"/>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED19432.1"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="822" mass="92314" checksum="5329C2B8830637A8" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8M512</accession>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000001745">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED19618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="444" mass="51478" checksum="3EBF4D9BB0F94BA7" modified="2009-03-03" version="1">MHRHNLSATSIRKKVSFDLADLTDDSDPEDYRDDYKSDWSPRSAVTGITPRRLRKYVIASLVFFVVLYITFNRSHPPRGLSPYLNYDAIDWSRYAYTQYVTDETYLCNSVMVFEALDRLGSRADRILFYPKSWDLFVSSEKDRLSQLLNLARDKYKVQLEPVTMDSLHEHKSEDLATWDESINKLWAFRETTYHRILQIDSDTLILQNLDELFFLPSATVAMPRAYWSSPGTMKLTSLLVLLEPSYKEYKALMEKVQGVEAGQLGTNRDESHELYDMELLNERYGGSALVLPHRQYGLVTGEFRTKDHRNFLGNDYETWNPDKVLSEAKLVHFSDWPLPKPWIMWPHGQLAKMQPVCDHNPGTPQESGCRDREVWKQLYEDFRLKRKDVCKLLSYPAPDWPPRPKDTSNLPNQPPPKQPSPQAPSVAYDVDVNANIDAKTEVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8M587</accession>
    <name>B8M587_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_029670</name>
    </gene>
    <organism evidence="3 4">
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        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED19693.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M587"/>
    <dbReference type="GeneID" id="8106534"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_029670"/>
    <dbReference type="eggNOG" id="ENOG502S4JF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_677862_0_0_1"/>
    <dbReference type="InParanoid" id="B8M587"/>
    <dbReference type="OMA" id="LLTTHEH"/>
    <dbReference type="OrthoDB" id="8864979at2759"/>
    <dbReference type="PhylomeDB" id="B8M587"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="50"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="364" mass="42405" checksum="4436C562F81CD98E" modified="2009-03-03" version="1">MRRLFSSPKKTSEGRHSSKERARKFGGLKRSKSSKVIVEDEERTLSSSYWDDLPVEIQISIFVECSVYDFLPLKLVCRGFYEVLTRHELVIAQEYLRRRRHDTLPSTIDHERTYTMNPEDDVVLLSDLFPPTKSARGGYLYTFRYLHTLRRRQDTCARLSYYLANRVMDRFFDSNQTFVKGMSASKSERDLMFEHGIAHLKFNFIPLTDLRFRTKGTFESFIKRLRSGKAPRTHPSERQTEFVDPTWIGGLLTASGLGRVVEYFSAEIGDGVKIRTRRRDFMINFEKDIDRYVREEMHPYVYVLPPSGQPHYPTVHEVWLDAAIRELRSRDAIPHDPGKLTIWNGAPMLMACDNCLAAEGWTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5B6</accession>
    <name>B8M5B6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_029930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480156.1">
        <property type="nucleotide sequence ID" value="XM_002480111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5B6"/>
    <dbReference type="GeneID" id="8106560"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_029930"/>
    <dbReference type="eggNOG" id="ENOG502SBZM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_696721_0_0_1"/>
    <dbReference type="InParanoid" id="B8M5B6"/>
    <dbReference type="OrthoDB" id="5403157at2759"/>
    <dbReference type="PhylomeDB" id="B8M5B6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="396" mass="43594" checksum="51760DD3CFAE71F6" modified="2009-03-03" version="1">MTPLVRKLLTLPPQTVFHWMTLLGKRHPGNKLPPLRHNTHHSTQQEQPSPQQLLIPLIPPRILQLHTILHPAALSLLHGTLIACSAVPCRMIRQDKSPGGRPRASGKSYKETRSPDPSFFVFLSAEINLDFSHQHFVFTLDSVETPPASPAPVEEPYESTAGSRPIPIPHANLSRSFEDLPLTPLTGRFDHQYLAERPKHQQSLSGQDKSSRKKKPRPSSLSVSTSTSNRSRPTKRMPMSGPSLAMSHQSGQVSPKPSPKDAPLYLNNLPRFHPAVYQSPNSTPNASLSPNTSNHHPRSFGYRVASGGSGSSREALRQYRELVAASVSLSRNNSDSSDAEISAPRLDPLGSPGPVTPLALEEAESYLSARNDYSSPRQADERERHGTTRTKDTKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5D4</accession>
    <name>B8M5D4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EF-hand calcium-binding domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_030090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002480129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5D4"/>
    <dbReference type="GeneID" id="8106576"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_030090"/>
    <dbReference type="eggNOG" id="KOG2551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051938_4_1_1"/>
    <dbReference type="InParanoid" id="B8M5D4"/>
    <dbReference type="OMA" id="LMFSQGC"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="PhylomeDB" id="B8M5D4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF7">
        <property type="entry name" value="SERINE HYDROLASE FSH DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="2"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="286" mass="32222" checksum="B666D0DADEACFAB9" modified="2009-03-03" version="1">MGRKIRILGLHGYGTSGAIFSSQTTSFRRFLQQQQQQHDQTGDGDEFDFDFANGPLDSGPAAGIELFYNPPYYQWWPADPTLEDMTKARERLKIYLKQNGPYDGVIMFSQGCTLGASLLLEHYKETPQDPPPFKFAIFICGGPSLKQLEAEFGFTIDAELWEVDRASRKALARRADTAAILAQGSNRWQNDVNDITDYSIKELVQMVRGPYQIRIPTVHVVGAKDPRNLAGHQLHALSHPDITKIYEHEGGHDIPRNETTSTTIARLVRWVSSSMIWDKAKQINGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5P7</accession>
    <name>B8M5P7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposon I factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_032000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002480330.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M5P7"/>
    <dbReference type="GeneID" id="8099813"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_032000"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_26_3_1"/>
    <dbReference type="InParanoid" id="B8M5P7"/>
    <dbReference type="OMA" id="WRHIDID"/>
    <dbReference type="OrthoDB" id="5080849at2759"/>
    <dbReference type="PhylomeDB" id="B8M5P7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="426"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="728" mass="80483" checksum="B7D5387CEC99929A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8M622</accession>
    <name>B8M622_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Onanonoxo-7-onima-8-eninoihtemlysoneda</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_023570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479456.1">
        <property type="nucleotide sequence ID" value="XM_002479411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M622"/>
    <dbReference type="STRING" id="441959.B8M622"/>
    <dbReference type="GeneID" id="8109539"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_023570"/>
    <dbReference type="eggNOG" id="KOG1401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010794_0_0_1"/>
    <dbReference type="InParanoid" id="B8M622"/>
    <dbReference type="OMA" id="KGWASRA"/>
    <dbReference type="OrthoDB" id="425114at2759"/>
    <dbReference type="PhylomeDB" id="B8M622"/>
    <dbReference type="UniPathway" id="UPA00078"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03109">
        <property type="entry name" value="DTBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000080">
        <property type="entry name" value="Bifunctional dethiobiotin synthetase/adenosylmethionine-8-amino-7-oxononanoate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00336">
        <property type="entry name" value="BioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004472">
        <property type="entry name" value="DTB_synth_BioD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684:SF3">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13500">
        <property type="entry name" value="AAA_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED19022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="794" mass="87902" checksum="A22F7CD6CC2E4719" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B8M656</accession>
    <name>B8M656_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Alpha-glucosidase, putative</fullName>
            <ecNumber evidence="17">3.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSTA_023890</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Has both alpha- and beta-glucosidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.3" evidence="17"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479490.1">
        <property type="nucleotide sequence ID" value="XM_002479445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M656"/>
    <dbReference type="STRING" id="441959.B8M656"/>
    <dbReference type="GeneID" id="8109571"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_023890"/>
    <dbReference type="eggNOG" id="KOG1065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000631_11_0_1"/>
    <dbReference type="InParanoid" id="B8M656"/>
    <dbReference type="OMA" id="YKGAVWP"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="PhylomeDB" id="B8M656"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004339">
        <property type="term" value="F:glucan 1,4-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF67">
        <property type="entry name" value="ALPHA_BETA-GLUCOSIDASE AGDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14 17" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 14 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877424" evidence="15">
        <location>
            <begin position="23"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="16">
        <location>
            <begin position="478"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EED19056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="992" mass="109425" checksum="8510780FC6642568" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B8M663</accession>
    <name>B8M663_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">TSTA_023960</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479497.1">
        <property type="nucleotide sequence ID" value="XM_002479452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M663"/>
    <dbReference type="FunCoup" id="B8M663">
        <property type="interactions" value="821"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M663"/>
    <dbReference type="GeneID" id="8109578"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_023960"/>
    <dbReference type="eggNOG" id="KOG0419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_10_2_1"/>
    <dbReference type="InParanoid" id="B8M663"/>
    <dbReference type="OMA" id="DHKSQYI"/>
    <dbReference type="OrthoDB" id="9984419at2759"/>
    <dbReference type="PhylomeDB" id="B8M663"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990304">
        <property type="term" value="C:MUB1-RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097505">
        <property type="term" value="C:Rad6-Rad18 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990305">
        <property type="term" value="C:RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990303">
        <property type="term" value="C:UBR1-RAD6 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034620">
        <property type="term" value="P:cellular response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071629">
        <property type="term" value="P:cytoplasm protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007535">
        <property type="term" value="P:donor selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042275">
        <property type="term" value="P:error-free postreplication DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031571">
        <property type="term" value="P:mitotic G1 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000639">
        <property type="term" value="P:negative regulation of SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090089">
        <property type="term" value="P:regulation of dipeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009302">
        <property type="term" value="P:sno(s)RNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120174">
        <property type="term" value="P:stress-induced homeostatically regulated protein degradation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000007">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0749">Sporulation</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 21" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="23">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="20">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EED19063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="151" mass="17183" checksum="9B83AB6BA2490656" modified="2009-03-03" version="1">MSTSARRRLMRDFKRMQTDPPAGVSASPVADNVMTWNAVIIGPADTPFEDGTFRLVMHFEEQYPNKPPGVKFISQMFHPNVYGTGELCLDILQNRWSPTYDVAAILTSIQSLLNDPNTSSPANVEASNLYKDNRREYVKRVRETVEKSWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6P7</accession>
    <name>B8M6P7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Trimethyllysine dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Epsilon-trimethyllysine 2-oxoglutarate dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">TML hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">TML-alpha-ketoglutarate dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSTA_028000</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6),N(6),N(6)-trimethyl-L-lysine + 2-oxoglutarate + O2 = (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:14181"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:58100"/>
            <dbReference type="ChEBI" id="CHEBI:141499"/>
            <dbReference type="EC" id="1.14.11.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.8" evidence="5"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479943.1">
        <property type="nucleotide sequence ID" value="XM_002479898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6P7"/>
    <dbReference type="STRING" id="441959.B8M6P7"/>
    <dbReference type="GeneID" id="8108316"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_028000"/>
    <dbReference type="eggNOG" id="KOG3889">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021859_2_2_1"/>
    <dbReference type="InParanoid" id="B8M6P7"/>
    <dbReference type="OMA" id="EKVCIQP"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="PhylomeDB" id="B8M6P7"/>
    <dbReference type="UniPathway" id="UPA00118"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050353">
        <property type="term" value="F:trimethyllysine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2020.30:FF:000002">
        <property type="entry name" value="Putative gamma-butyrobetaine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000001">
        <property type="entry name" value="Trimethyllysine dioxygenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012776">
        <property type="entry name" value="Trimethyllysine_dOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02410">
        <property type="entry name" value="carnitine_TMLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF51">
        <property type="entry name" value="TRIMETHYLLYSINE DIOXYGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="8 19" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="18">
        <location>
            <begin position="165"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="17">
        <location>
            <begin position="263"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00071191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EED19509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="536" mass="61176" checksum="FECEECF43F4E2437" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6Q7</accession>
    <name>B8M6Q7_TALSN</name>
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        <recommendedName>
            <fullName evidence="2">GDS1 winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_028100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479953.1">
        <property type="nucleotide sequence ID" value="XM_002479908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6Q7"/>
    <dbReference type="STRING" id="441959.B8M6Q7"/>
    <dbReference type="GeneID" id="8108326"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_028100"/>
    <dbReference type="eggNOG" id="ENOG502S2UH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036462_1_0_1"/>
    <dbReference type="InParanoid" id="B8M6Q7"/>
    <dbReference type="OMA" id="MVFDSWR"/>
    <dbReference type="OrthoDB" id="4150221at2759"/>
    <dbReference type="PhylomeDB" id="B8M6Q7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057511">
        <property type="entry name" value="WH_GDS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25318">
        <property type="entry name" value="WHD_GDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDS1 winged helix" evidence="2">
        <location>
            <begin position="99"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="490" mass="52950" checksum="DBF3704A381352F8" modified="2009-03-03" version="1">MPYNTRRKSLSLPSLGIHLPNASRSHRSPSASKSSTSGSTILDEHPSKKVKRSHDVADSSTSADKSQKVATGRIRNSRGGYEHTPPPSPGDAVDAAMKIDTEGINDDVVVAAIEQLEKTGNKPHLVRELAAVLVKINDTVANSANPAALLSSRLSTYMKRSWTALSPCPIGKELINVHPRKVFYYLTNTPHQPLPENLEDMVAMDEKRLTPSLSSGSVDQDDEDDAMARERSRLSPSPEIDLSSPEFEVEHDTFNARNGSGSHTNQNNGHHRLSHNHRAASPPLEGDEREFTQTASSLRERASEEKASRQSSLAALSMPTSDESHDAQIHAFPGSPMDEDPLTTSISEKSQYGDYLSQGGSNNQEQDLDDAAVATLFGTSPSPSLTSVATSLSSGTTAPSEAELADVPLALPTSDLARSNTATATATEGTSPSSLKRSFDMVETGFPTKSVTDFKRSQTFDFEMVIDSWADLRSPETVEVDELDEMFGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8G8</accession>
    <name>B8M8G8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_037020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480915.1">
        <property type="nucleotide sequence ID" value="XM_002480870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8G8"/>
    <dbReference type="GeneID" id="8100548"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_037020"/>
    <dbReference type="HOGENOM" id="CLU_1300083_0_0_1"/>
    <dbReference type="InParanoid" id="B8M8G8"/>
    <dbReference type="OrthoDB" id="5384979at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="185" mass="21071" checksum="12B0DB5E212FB201" modified="2009-03-03" version="1">MNEDGELLGRFCETPTTYTDPPDELAVSVLEEQNVNEDDNHSPNKEETSLSENLIKETHLLNGHDESSPIHDGLTPRIVVTGTRASEAIHPRQPPLYTEGDDENIDEAEVPGGETAINKPYLQNPIVSHCGEGRDRRFLVWQSEEELRLQKSEWLTLYWEQQDVLEKASKLPASRTNFPKRKRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8H2</accession>
    <name>B8M8H2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposable element tc3 transposase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_037060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480919.1">
        <property type="nucleotide sequence ID" value="XM_002480874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8H2"/>
    <dbReference type="STRING" id="441959.B8M8H2"/>
    <dbReference type="GeneID" id="8100552"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_037060"/>
    <dbReference type="eggNOG" id="ENOG502SEY1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033666_0_1_1"/>
    <dbReference type="InParanoid" id="B8M8H2"/>
    <dbReference type="OMA" id="MQARCEA"/>
    <dbReference type="OrthoDB" id="5415741at2759"/>
    <dbReference type="PhylomeDB" id="B8M8H2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052338">
        <property type="entry name" value="Transposase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022:SF119">
        <property type="entry name" value="TC1-LIKE TRANSPOSASE DDE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022">
        <property type="entry name" value="TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="2">
        <location>
            <begin position="98"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED20485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="253" mass="29434" checksum="D812992257A0A25C" modified="2009-03-03" version="1">MPTTPEPTTAQEAAPAAASREESKPYSIRLNRDDRIRILTLRDAGFTYLEIATMLHVTHDQVQYTCQSQRATPKKARGKTPKLSEEDVDRIIEWISSSKRTRRMPYYKVVHELNLPVGATALARALKKRGYTRCKALRKPPLSDEHKRVRLAWALEHVNWSIEQWNRILWTDETWVTSAFSPDLNPIEAVWNWMKDWIQEQYPNDEQLSYDRLREVVRASWDALPDQFLKDLIDSMQARCEAVIAAEGGHTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9H4</accession>
    <name>B8M9H4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_115330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481726.1">
        <property type="nucleotide sequence ID" value="XM_002481681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9H4"/>
    <dbReference type="GeneID" id="8101343"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_115330"/>
    <dbReference type="HOGENOM" id="CLU_046030_0_0_1"/>
    <dbReference type="InParanoid" id="B8M9H4"/>
    <dbReference type="OrthoDB" id="1421156at2759"/>
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            <end position="73"/>
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            <dbReference type="Pfam" id="PF10551"/>
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    </evidence>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000001745"/>
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    <sequence length="433" mass="49974" checksum="D493D4E731DDBF26" modified="2009-03-03" version="1">MPLLDIVGCTGTNKTFWVGFGFMKNEKEESYLFILKSLEQNLMVKCRPALRQEVIRIDYEGKGMKSTLVDEFKEKVEAHWVAFWQDFMKLVNAYTEEEKDAEWNNFRAKYSHNVWDTVFEYIKKEWLQEDTAKHFLKCYTNEYLHLNKQASSQVEGAHWIIKRDLGTSTMDLLGATLSIEMTIEKQHQKIWQEIEDERVRIKIDFKNLRLFKHVLKKVSSHALKIIHSIFERYLPESAPDKKPIKPCTGVTRRTLGIPCIHKIKEYYEADTSIELFEFCPHWRLHTDEDLPPVDPRELVLEPEVIRPRGRPPGAINWPTTSEQSQSAEDRSTRRDPSAFEHLLTQESSRGRGSGHVRGSRGGGQAGRGRGGRQQGGECGSGSAGTSEVSTQSHENDDNEISENRDDKTNENQIRRSKRRGRGQPAPWLGDENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9Q0</accession>
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        <submittedName>
            <fullName evidence="4">UBA/TS-N domain protein</fullName>
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        <name evidence="4" type="ORF">TSTA_118220</name>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        <location>
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            <end position="527"/>
        </location>
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        </location>
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    </feature>
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        <source>
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        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED18052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="907" mass="98768" checksum="ABD89EDFADB4396E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9R6</accession>
    <name>B8M9R6_TALSN</name>
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        <submittedName>
            <fullName evidence="9">Integral membrane protein, putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="ORF">TSTA_118370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
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            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
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    <dbReference type="eggNOG" id="ENOG502S025">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
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            <begin position="35"/>
            <end position="271"/>
        </location>
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        <location>
            <begin position="322"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="367"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED18068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="378" mass="41417" checksum="549457D658305C8A" modified="2009-03-03" version="1">MSTPDTQVLSMGHESTHSIIAGLVLMGVATLLVAVRFYTRRHIIKAVQWSDWTVLVALMLSMAFVGIFITAVLYGMGLQEAEITTTDFNRQKKLFWVSVPFYNAAMVTAKASIIIQYFHVFPTKQMRIVCWMVSTILTIYGVWSVLSAFLNCIPVASFWDSSTEGHCLDYKGLWYSNTALNIVTDVVILIIPVPALAALDLSLRQKVGLCCVFAVGGFVCITSVFRLLSVIALVSSNGRSYDCLAVMMWSAIECNTGIICACLPTLRPAIVRLWPALSGLLVSRRQRSSSDSITSFYGGSENSAALFGRDVHITTRGVESNRGSVVKAKSGTDSDRGSGMQQAPNVRMVPMPGNGFAQDLARKGSFFEQQQQRPSSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9V5</accession>
    <name>B8M9V5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bacteriophage T5 Orf172 DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_118730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482099.1">
        <property type="nucleotide sequence ID" value="XM_002482054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9V5"/>
    <dbReference type="STRING" id="441959.B8M9V5"/>
    <dbReference type="GeneID" id="8099797"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_118730"/>
    <dbReference type="eggNOG" id="ENOG502QWMU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024511_1_0_1"/>
    <dbReference type="InParanoid" id="B8M9V5"/>
    <dbReference type="OMA" id="AAAYFCW"/>
    <dbReference type="OrthoDB" id="2417614at2759"/>
    <dbReference type="PhylomeDB" id="B8M9V5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053006">
        <property type="entry name" value="Meiosis_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094:SF2">
        <property type="entry name" value="BACTERIOPHAGE T5 ORF172 DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10544">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00974">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacteriophage T5 Orf172 DNA-binding" evidence="2">
        <location>
            <begin position="343"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED18107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="455" mass="50987" checksum="9207523AC5A91BE5" modified="2009-03-03" version="1">MPQFPNTPESILPRSDSRNPASTCRGITVNGKPCRRSLAASQSASASKGVVARLKGQNQQLDPSAFYCWQHKNQAPEPGDISTENKQAQAAAFARKTSIDSLIERLGILEVNDRQRQHRRPTERDARYQRMHSDKNPKPGRGQQPRQSPFCCFTIVEDSENLPAAKRVQSSRREKPVASRPPATPQRPVFVRDPRSGGSPIVQQRSAPVTPRRWSETTPQATLQSADRSQYLGTPTKPSLPSTPNSHSSQNRPLLSLIPQHLSPQTTALLLTELSKPISNADEEGYIYIFWVTPQKHNSEAPPGDIALNLLPPPGRPNHSRRTSDALRAAQAIDPRSKGSANQPGTIRLKIGRTSNVHRRLNEYYPYTNSSPSPSPARRPESEHFQGHGRRVPHVHRVERLIHIELADQRVKGKGPCAQCNKEHREWFEFNATKDALKLVDDCVRRWVAWGEQHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MA58</accession>
    <name>B8MA58_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA family ATPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_121300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482379.1">
        <property type="nucleotide sequence ID" value="XM_002482334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MA58"/>
    <dbReference type="STRING" id="441959.B8MA58"/>
    <dbReference type="GeneID" id="8099370"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_121300"/>
    <dbReference type="eggNOG" id="KOG0730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_12_3_1"/>
    <dbReference type="InParanoid" id="B8MA58"/>
    <dbReference type="OMA" id="KPPTIHW"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="PhylomeDB" id="B8MA58"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001721">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="238"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="513"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED18387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="742" mass="82130" checksum="EA71FEC1AC145B95" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBE6</accession>
    <name>B8MBE6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">RNA binding protein (Arp), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSTA_116020</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481802.1">
        <property type="nucleotide sequence ID" value="XM_002481757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBE6"/>
    <dbReference type="FunCoup" id="B8MBE6">
        <property type="interactions" value="144"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MBE6"/>
    <dbReference type="GeneID" id="8099629"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_116020"/>
    <dbReference type="eggNOG" id="KOG4198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022834_2_0_1"/>
    <dbReference type="InParanoid" id="B8MBE6"/>
    <dbReference type="OMA" id="DWKCGEN"/>
    <dbReference type="OrthoDB" id="448399at2759"/>
    <dbReference type="PhylomeDB" id="B8MBE6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140453">
        <property type="term" value="C:protein aggregate center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071502">
        <property type="term" value="P:cellular response to temperature stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031445">
        <property type="term" value="P:regulation of heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12452">
        <property type="entry name" value="RRM_ARP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000021">
        <property type="entry name" value="MUTL protein homolog 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000024">
        <property type="entry name" value="RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034351">
        <property type="entry name" value="Nrp1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23111:SF40">
        <property type="entry name" value="RNA-BINDING PROTEIN INVOLVED IN HETEROCHROMATIN ASSEMBLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23111">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="253"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="15">
        <location>
            <begin position="352"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="15">
        <location>
            <begin position="422"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="474"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="589"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EED17810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="612" mass="65571" checksum="09AC47A9A40D3291" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBH2</accession>
    <name>B8MBH2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cellulose-binding Sde182 nucleoside hydrolase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_116260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481828.1">
        <property type="nucleotide sequence ID" value="XM_002481783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBH2"/>
    <dbReference type="STRING" id="441959.B8MBH2"/>
    <dbReference type="GeneID" id="8099653"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_116260"/>
    <dbReference type="eggNOG" id="ENOG502QXBB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1120749_0_0_1"/>
    <dbReference type="InParanoid" id="B8MBH2"/>
    <dbReference type="OrthoDB" id="3592035at2759"/>
    <dbReference type="PhylomeDB" id="B8MBH2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011483">
        <property type="entry name" value="Sde182_NH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07632">
        <property type="entry name" value="Sde182_NH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cellulose-binding Sde182 nucleoside hydrolase-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="248" mass="28519" checksum="57CC38DE3B49EFE8" modified="2009-03-03" version="1">MHKIVDGYEKVADNLNAHVHPNDPYPTTEYLRSSIKMGAEVLFLERIEVSSEQPLWILCWAGTNVLASVLLSRKYTFFLGRCRVTVKITRLHDLRPGRYWRVDPQQVLCTYPDIFCICSIHGWSQCGLATWSSISGERWYGFDHGGPDPTRVSKDWIRKNIQIGPLGSVYPDVMVIPEGDTLTFLYLIQNSLGVPEHPDYGSWGRRYNRTSTTSGNRYYSDVADEMIGLDGRKHKSNQATIWRWRNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBT8</accession>
    <name>B8MBT8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="15">PARP</shortName>
            <ecNumber evidence="15">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TSTA_119780</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).</text>
            <dbReference type="EC" id="2.4.2.30"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="15"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482213.1">
        <property type="nucleotide sequence ID" value="XM_002482168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBT8"/>
    <dbReference type="STRING" id="441959.B8MBT8"/>
    <dbReference type="GeneID" id="8105253"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119780"/>
    <dbReference type="eggNOG" id="KOG1037">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004841_2_0_1"/>
    <dbReference type="InParanoid" id="B8MBT8"/>
    <dbReference type="OMA" id="QGENDRF"/>
    <dbReference type="OrthoDB" id="2017365at2759"/>
    <dbReference type="PhylomeDB" id="B8MBT8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17731">
        <property type="entry name" value="BRCT_TopBP1_rpt2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01437">
        <property type="entry name" value="parp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07997">
        <property type="entry name" value="WGR_PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.142.10:FF:000002">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.140.10:FF:000001">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.142.10">
        <property type="entry name" value="Poly(ADP-ribose) polymerase, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.140.10">
        <property type="entry name" value="WGR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050800">
        <property type="entry name" value="ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059215">
        <property type="entry name" value="BRCT2_TopBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004102">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036616">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036930">
        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008893">
        <property type="entry name" value="WGR_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459:SF60">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02877">
        <property type="entry name" value="PARP_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05406">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00773">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47587">
        <property type="entry name" value="Domain of poly(ADP-ribose) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142921">
        <property type="entry name" value="WGR domain-like"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51977">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 15 21" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="WGR" evidence="20">
        <location>
            <begin position="164"/>
            <end position="260"/>
        </location>
    </feature>
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        <location>
            <begin position="296"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="18">
        <location>
            <begin position="432"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="107"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="260"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EED18221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="666" mass="74187" checksum="CE508421D8ACFB94" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MC05</accession>
    <name>B8MC05_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">1,3-beta-glucan biosynthesis protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_121890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KNR4/SMI1 family.</text>
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        <property type="protein sequence ID" value="EED18451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002482398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MC05"/>
    <dbReference type="STRING" id="441959.B8MC05"/>
    <dbReference type="GeneID" id="8098178"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_121890"/>
    <dbReference type="eggNOG" id="ENOG502QTAZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024700_0_0_1"/>
    <dbReference type="InParanoid" id="B8MC05"/>
    <dbReference type="OMA" id="ESLMVHD"/>
    <dbReference type="OrthoDB" id="2305498at2759"/>
    <dbReference type="PhylomeDB" id="B8MC05"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070880">
        <property type="term" value="P:fungal-type cell wall beta-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009203">
        <property type="entry name" value="Knr4/Smi1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051873">
        <property type="entry name" value="KNR4/SMI1_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432:SF1">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017023">
        <property type="entry name" value="KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="161"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="388"/>
            <end position="532"/>
        </location>
    </feature>
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        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="461"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="491"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED18451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="532" mass="58681" checksum="7BCD808455122A27" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDH4</accession>
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        <submittedName>
            <fullName evidence="7">C6 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_117230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481929.1">
        <property type="nucleotide sequence ID" value="XM_002481884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MDH4"/>
    <dbReference type="GeneID" id="8105781"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_117230"/>
    <dbReference type="eggNOG" id="ENOG502SMPB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004835_3_0_1"/>
    <dbReference type="InParanoid" id="B8MDH4"/>
    <dbReference type="OMA" id="RHIIYRP"/>
    <dbReference type="OrthoDB" id="4685598at2759"/>
    <dbReference type="PhylomeDB" id="B8MDH4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED17937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="603" mass="68306" checksum="8EF025B12F48865F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDH9</accession>
    <name>B8MDH9_TALSN</name>
    <protein>
        <recommendedName>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="CID_dom"/>
    </dbReference>
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        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323:SF0">
        <property type="entry name" value="CALCIUM HOMEOSTASIS ENDOPLASMIC RETICULUM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323">
        <property type="entry name" value="SR-RELATED CTD ASSOCIATED FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
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    </dbReference>
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        <location>
            <begin position="25"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="547"/>
        </location>
    </feature>
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        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
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        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
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        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED17942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="547" mass="60715" checksum="58C129D07C861147" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Arginase/deacetylase"/>
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        </location>
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        </location>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1274" mass="137610" checksum="BCA925203379A570" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEP2</accession>
    <name>B8MEP2_TALSN</name>
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            <fullName evidence="5">Integral membrane protein</fullName>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
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            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002484114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEP2"/>
    <dbReference type="STRING" id="441959.B8MEP2"/>
    <dbReference type="GeneID" id="8108796"/>
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    <dbReference type="eggNOG" id="ENOG502SMQ2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_594423_0_0_1"/>
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    <dbReference type="PhylomeDB" id="B8MEP2"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877697" description="Integral membrane protein" evidence="2">
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            <begin position="22"/>
            <end position="485"/>
        </location>
    </feature>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="54091" checksum="22325DB61C8175F5" modified="2009-03-03" version="1">MASNLGLIYTLLQTATATATATDQTTDQTSDRKLLPLALPNRPDATLKNSTDVTFDPLGVAAVLHNPRASLSAARLYTQFDRNYFTWPHTMMMGSMEHLTANFQSIHPAITLCTRDTQLLSVVSNMVFKELPLDWGNMWLGDVIAFKASSRPANDFMVVCMDDDDGDSASIKDGPSKWTRWLGCSALNLISLVNGLIIVAGIVLGVLSADIWALTLFFFYGTHWLAGLAISTTSLVTPQRISIKEDATTRYAIYQRPAGGTVVFKGRQDTMEAWARSTWEFNRTLKSNCLHWFWTLTGTMSAICSVACMVNMIGYMQLAFLALLVYASLAEIGATRITRLLQGEAKALNRTCIVANNEFRTKGVIRATVEVGRKYRLKGLDWVDLKRMPPDRIFRDMQRLLARLNAFQEGVEMGKEKVATDGHDDVSGLRDHGVVQGAFREFREGRTEDPVLVERIQTEAMDALEQWWVKLNRDTVNVTTKVVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MET3</accession>
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        <submittedName>
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    <gene>
        <name evidence="8" type="ORF">TSTA_020240</name>
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    <organism evidence="8 9">
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        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484200.1">
        <property type="nucleotide sequence ID" value="XM_002484155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MET3"/>
    <dbReference type="FunCoup" id="B8MET3">
        <property type="interactions" value="128"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MET3"/>
    <dbReference type="GeneID" id="8108835"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_020240"/>
    <dbReference type="eggNOG" id="KOG1347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_1_2_1"/>
    <dbReference type="InParanoid" id="B8MET3"/>
    <dbReference type="OMA" id="WFFVWKL"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="PhylomeDB" id="B8MET3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="496"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="599"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED16966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="637" mass="69047" checksum="8220CF71D952F81D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8MF71</accession>
    <name>B8MF71_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF167 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_012770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0235 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="AlphaFoldDB" id="B8MF71"/>
    <dbReference type="STRING" id="441959.B8MF71"/>
    <dbReference type="GeneID" id="8108153"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_012770"/>
    <dbReference type="eggNOG" id="KOG3276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130694_1_0_1"/>
    <dbReference type="InParanoid" id="B8MF71"/>
    <dbReference type="OMA" id="QIACHVK"/>
    <dbReference type="OrthoDB" id="244097at2759"/>
    <dbReference type="PhylomeDB" id="B8MF71"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00251">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420">
        <property type="entry name" value="UPF0235 PROTEIN C15ORF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420:SF7">
        <property type="entry name" value="UPF0235 PROTEIN C15ORF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="124" mass="13800" checksum="C82A8D47FD98F8BF" modified="2009-03-03" version="1">MNEVPKLLRLKSVVHKHSKTLYTLLIRCHVTPGSRGFQGIKQIHNEQVYVHVGSEPRKGEANTAVARVLSEVLGFPKSDVIIVGKQRVKIGQVTGVDIGKLSEEEYISKVRQKLVDACFGKPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFF0</accession>
    <name>B8MFF0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Maintenance of telomere capping protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_017580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483918.1">
        <property type="nucleotide sequence ID" value="XM_002483873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFF0"/>
    <dbReference type="FunCoup" id="B8MFF0">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MFF0"/>
    <dbReference type="GeneID" id="8109015"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_017580"/>
    <dbReference type="eggNOG" id="ENOG502QU4J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034224_0_1_1"/>
    <dbReference type="InParanoid" id="B8MFF0"/>
    <dbReference type="OMA" id="RIHLVHD"/>
    <dbReference type="OrthoDB" id="5594977at2759"/>
    <dbReference type="PhylomeDB" id="B8MFF0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018814">
        <property type="entry name" value="DUF5427"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265:SF1">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10310">
        <property type="entry name" value="DUF5427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="53263" checksum="81793F0F56FA45AB" modified="2009-03-03" version="1">MPPKGTKPTNDELLAQFDDLGIDTTGKSSEQTSAPPTTTTTKPASTEPSTTAVVKDPLAELENLASQRPSTPRLSAEARRPKPSSGRTSEEKPPTQPHAAAVEDEQQAEKAPVVPPQEETKSSGGGWWGGFLSTATATATAAMKQAEAAVKEIQKNEEAQKWAEQVRGNVGALRGLGGELRTLALPTFTSIIHTLAPPISSHERLQIHITHDLSGYPSLEPIIHSVFARVMSQVEGGDLLVIQRGQESAPRRGTDFGFQSSITGWRDGPWWRTITPGTPRSIAAVPGVVPGTKLARASAEAYATEFYSLRGGLEEAAKQATEVLSESNPVRSSDIFLAIQAISQITPKDLFQAGPTAEKSTSESAGGVVEIAEEDEEEILFAVYLHDPVHGIAFSTISQTIPRKWIDWLDASAPASDDDTRTKIPEAIQDIIESGGVDPREWVSEWLEESLSLSTGVVAQRYVARRMGVGEGGTAKGKLRAEQATTIEGGAGEAARTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8MG82</accession>
    <name>B8MG82_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_010650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483183.1">
        <property type="nucleotide sequence ID" value="XM_002483138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MG82"/>
    <dbReference type="GeneID" id="8109838"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_010650"/>
    <dbReference type="eggNOG" id="ENOG502SSXE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074415_0_0_1"/>
    <dbReference type="InParanoid" id="B8MG82"/>
    <dbReference type="OrthoDB" id="3862662at2759"/>
    <dbReference type="PhylomeDB" id="B8MG82"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF2">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="140"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="189"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED15949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="272" mass="30412" checksum="400782499FF9E9CA" modified="2009-03-03" version="1">MDTGTVRREILHPIACEPCRQKKCKCDREIPVCSQCLGEPSKCNYPESGKRGLPLGYITQLEQRLAVTELALFEALATLHSLGHDETGLVKASVKSGIESRQGKQSLMEEWRKLPLRDGLTEDIETWWQAKSEKYLIQQPSAERDQPQDQLKPLSTGHSPENVTENDTITSPQASPVMEFAVSTGAAPSYPRNVHYDNDIPRQRPNFSRERVSSTDAEQHHATPEVGTGYRSIMPRETRGSEFFSSHDVQRSDAGDGNKAAILARTQSSLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGZ4</accession>
    <name>B8MGZ4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_014670</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483609.1">
        <property type="nucleotide sequence ID" value="XM_002483564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGZ4"/>
    <dbReference type="GeneID" id="8107850"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_014670"/>
    <dbReference type="eggNOG" id="ENOG502SIGA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016509_1_0_1"/>
    <dbReference type="InParanoid" id="B8MGZ4"/>
    <dbReference type="OMA" id="YVPRKEG"/>
    <dbReference type="OrthoDB" id="2283488at2759"/>
    <dbReference type="PhylomeDB" id="B8MGZ4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR ASQA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="284"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED16375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="601" mass="68394" checksum="31F5D045AFB562E4" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHA0</accession>
    <name>B8MHA0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-phytase</fullName>
            <ecNumber evidence="2">3.1.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_021360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.8" evidence="2"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484313.1">
        <property type="nucleotide sequence ID" value="XM_002484268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHA0"/>
    <dbReference type="STRING" id="441959.B8MHA0"/>
    <dbReference type="GeneID" id="8109393"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_021360"/>
    <dbReference type="eggNOG" id="KOG1382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020880_3_0_1"/>
    <dbReference type="InParanoid" id="B8MHA0"/>
    <dbReference type="OMA" id="ANSPWFA"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="PhylomeDB" id="B8MHA0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF23">
        <property type="entry name" value="3-PHYTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002875113" description="3-phytase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="70"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="450"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED17079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="512" mass="55526" checksum="3A3CA1C80C555341" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHD8</accession>
    <name>B8MHD8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_021740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484351.1">
        <property type="nucleotide sequence ID" value="XM_002484306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHD8"/>
    <dbReference type="STRING" id="441959.B8MHD8"/>
    <dbReference type="GeneID" id="8098440"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_021740"/>
    <dbReference type="eggNOG" id="ENOG502QQUZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009044_0_0_1"/>
    <dbReference type="InParanoid" id="B8MHD8"/>
    <dbReference type="OMA" id="GRHFWAQ"/>
    <dbReference type="OrthoDB" id="66409at2759"/>
    <dbReference type="PhylomeDB" id="B8MHD8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052809">
        <property type="entry name" value="Actin_polarity_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012860">
        <property type="entry name" value="Afi1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245:SF1">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07792">
        <property type="entry name" value="Afi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08616">
        <property type="entry name" value="SPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="87"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED17117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="798" mass="89200" checksum="8DB9E193088D5065" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MI15</accession>
    <name>B8MI15_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diaminopropionate ammonia-lyase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_022310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484411.1">
        <property type="nucleotide sequence ID" value="XM_002484366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MI15"/>
    <dbReference type="STRING" id="441959.B8MI15"/>
    <dbReference type="GeneID" id="8107068"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_022310"/>
    <dbReference type="eggNOG" id="KOG2275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_8_4_1"/>
    <dbReference type="InParanoid" id="B8MI15"/>
    <dbReference type="OMA" id="MMNGHID"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="PhylomeDB" id="B8MI15"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006058">
        <property type="entry name" value="PRK08206.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42937">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42937:SF1">
        <property type="entry name" value="DIAMINOPROPIONATE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="2">
        <location>
            <begin position="36"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="3">
        <location>
            <begin position="552"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED17177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="759" mass="81512" checksum="5900D6F2BF9E6A64" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIE6</accession>
    <name>B8MIE6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tetracycline-efflux transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_041090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484583.1">
        <property type="nucleotide sequence ID" value="XM_002484538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIE6"/>
    <dbReference type="GeneID" id="8099917"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_041090"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_3_1"/>
    <dbReference type="InParanoid" id="B8MIE6"/>
    <dbReference type="OMA" id="ADTNYIA"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="PhylomeDB" id="B8MIE6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF33">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="62"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED14630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="556" mass="59120" checksum="8DC53D755B7B0E34" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIS8</accession>
    <name>B8MIS8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_050290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485543.1">
        <property type="nucleotide sequence ID" value="XM_002485498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIS8"/>
    <dbReference type="STRING" id="441959.B8MIS8"/>
    <dbReference type="GeneID" id="8109403"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_050290"/>
    <dbReference type="eggNOG" id="ENOG502SI1U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013296_1_1_1"/>
    <dbReference type="InParanoid" id="B8MIS8"/>
    <dbReference type="OMA" id="THNTCVE"/>
    <dbReference type="OrthoDB" id="4898680at2759"/>
    <dbReference type="PhylomeDB" id="B8MIS8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF82">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="10"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="635"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="645"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED15590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="742" mass="84235" checksum="F96074A105323571" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJ36</accession>
    <name>B8MJ36_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_051340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485651.1">
        <property type="nucleotide sequence ID" value="XM_002485606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJ36"/>
    <dbReference type="STRING" id="441959.B8MJ36"/>
    <dbReference type="GeneID" id="8106336"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_051340"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_26_3_1"/>
    <dbReference type="InParanoid" id="B8MJ36"/>
    <dbReference type="OrthoDB" id="4357294at2759"/>
    <dbReference type="PhylomeDB" id="B8MJ36"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="592" mass="65667" checksum="EEF991354BA82164" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-04-05" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJK3</accession>
    <name>MIC60_TALSN</name>
    <protein>
        <recommendedName>
            <fullName>MICOS complex subunit MIC60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Mitofilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MIC60</name>
        <name type="ORF">TSTA_046570</name>
    </gene>
    <organism>
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485156.1">
        <property type="nucleotide sequence ID" value="XM_002485111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJK3"/>
    <dbReference type="SMR" id="B8MJK3"/>
    <dbReference type="FunCoup" id="B8MJK3">
        <property type="interactions" value="169"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MJK3"/>
    <dbReference type="GeneID" id="8099568"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_046570"/>
    <dbReference type="eggNOG" id="KOG1854">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008024_1_2_1"/>
    <dbReference type="InParanoid" id="B8MJK3"/>
    <dbReference type="OMA" id="RLDHQMQ"/>
    <dbReference type="OrthoDB" id="10261039at2759"/>
    <dbReference type="PhylomeDB" id="B8MJK3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415:SF7">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415">
        <property type="entry name" value="MITOFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000406675" description="MICOS complex subunit MIC60">
        <location>
            <begin position="39"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="2">
        <location>
            <begin position="39"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="2">
        <location>
            <begin position="134"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="168"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="309"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="639" mass="70808" checksum="363C6D185688DAA4" modified="2009-03-03" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJP0</accession>
    <name>B8MJP0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pogo transposable element, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_051760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485692.1">
        <property type="nucleotide sequence ID" value="XM_002485647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJP0"/>
    <dbReference type="GeneID" id="8103397"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_051760"/>
    <dbReference type="eggNOG" id="ENOG502S2ZX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_4_0_1"/>
    <dbReference type="InParanoid" id="B8MJP0"/>
    <dbReference type="OMA" id="LEPERIC"/>
    <dbReference type="OrthoDB" id="6115549at2759"/>
    <dbReference type="PhylomeDB" id="B8MJP0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="60"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED15739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="540" mass="61719" checksum="BB60FEBE3E42EFEA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJU9</accession>
    <name>B8MJU9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Capsule polysaccharide biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_042410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484719.1">
        <property type="nucleotide sequence ID" value="XM_002484674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJU9"/>
    <dbReference type="GeneID" id="8103334"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_042410"/>
    <dbReference type="eggNOG" id="ENOG502SEFD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061936_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJU9"/>
    <dbReference type="OMA" id="GSLWRDN"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="PhylomeDB" id="B8MJU9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008441">
        <property type="entry name" value="AfumC-like_glycosyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05704">
        <property type="entry name" value="Caps_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED14766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="43902" checksum="1BEDE476BEB18B91" modified="2009-03-03" version="1">MEHPSYPIPGGLHKIPDDLLDLRPDEEVDQDLLNPKPVTDVKNIWFFWHTGYKNMHPYTQRNPSSPLNVANFLDIADPGTFPRAFVDGTIGGDYAPQHTSDLVRWPLLLKYGGVYADVGLMQIGDLDRLWNETVGNPNSRFEVLSYNAGGVDGRSLTNYFLASNCNNSFFARCHRLFLELWAVDGGKTSTDGMHCSPLLKGVPLMGGDFTIQEDDKVLGKEDVSRLLTDYIIQGQVLTMVMGLVDEEDGWNGPQYVADHIYGIEFMEGCQLINEFTKWDGQKAFDLMSLPLPRHGELESPEQRQAREIVVSCLRRSFGFKLAHGLILRVFKVTLGSLWRDNPGSDNVPNTYAHWLRHATTYWNQDHIPSTLEFRVIPPFKKGPLLRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MK74</accession>
    <name>B8MK74_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha</fullName>
            <ecNumber evidence="4">2.5.1.58</ecNumber>
            <ecNumber evidence="3">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">CAAX farnesyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FTase-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ras proteins prenyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Type I protein geranyl-geranyltransferase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_046810</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="4"/>
    <dbReference type="EC" id="2.5.1.59" evidence="3"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485182.1">
        <property type="nucleotide sequence ID" value="XM_002485137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MK74"/>
    <dbReference type="FunCoup" id="B8MK74">
        <property type="interactions" value="188"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MK74"/>
    <dbReference type="GeneID" id="8108045"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_046810"/>
    <dbReference type="eggNOG" id="KOG0530">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026582_1_0_1"/>
    <dbReference type="InParanoid" id="B8MK74"/>
    <dbReference type="OMA" id="WAIRTFN"/>
    <dbReference type="OrthoDB" id="272289at2759"/>
    <dbReference type="PhylomeDB" id="B8MK74"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF1">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE_GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED15229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="346" mass="40315" checksum="F7AACF381A88EF92" modified="2009-03-03" version="1">MEQGKYNTSPDWTDINPIPLDDGSQEEEGITSLAAIAYKPEYLEATSYLRAVMAANEMSERVLQLTEDVIMMNPAHYTVWLYRAKILFALKKDLTQELVWLNKVSLKYLKNYQIWHHRQQLLSSKEHFPTLPEGEQDFLMQMFDADSKNYHVWSYRQWLVRQFNLWDDPREMSDVELLISEDVRNNSAWNHRYLLRFAPRQGAEAAMSVASDASEKGCLNVVDEDVVDAELEYAQKKILRAPENRSPWLYARGVLRAAGRSLAEWKGFASRFFTEEISDAATPIVHVKSSLALEWLADVFCQEAREQQQKEKVDEAVKMLTLLKERYDPIRKNYWDYKIGQLSVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKS9</accession>
    <name>B8MKS9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Indoleamine 2,3-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_043960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Produces N-formyl-kynurenine through the oxidation of tryptophan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.52" evidence="4"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484881.1">
        <property type="nucleotide sequence ID" value="XM_002484836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKS9"/>
    <dbReference type="STRING" id="441959.B8MKS9"/>
    <dbReference type="GeneID" id="8097904"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_043960"/>
    <dbReference type="eggNOG" id="ENOG502RZ6X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010089_0_1_1"/>
    <dbReference type="InParanoid" id="B8MKS9"/>
    <dbReference type="OMA" id="WHQYSGG"/>
    <dbReference type="OrthoDB" id="540174at2759"/>
    <dbReference type="PhylomeDB" id="B8MKS9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF10">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00876">
        <property type="entry name" value="IDO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED14928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="347" mass="38969" checksum="EB2A30F228AC8A97" modified="2009-03-03" version="1">MLNIPSPPIPLDEFRVSYETGFLPVHSTANNKKLPLHRLSNPYYTPWEDVMTNLPRLIQSGEIRKKILDLPVLSVNGLDANEEAEWQRAYLVLAFLTHAYIWGGKKAEDKLPPSISRPFVEISAHLELPPCATYAALNLWNFTTKPSEDNEDIDLTNPDNLYTINSFTGTDDERWFLVVSVAMEACGAKMIRLVLDSIVTINMTTNNTSEDDGNTDISSNRNVILTNLLNEMGKCIDELGHILERMYERNDPMTFYHQIRPLLAGSKNMAAAGLPNGMFYDTGDNNGRWHQYSGGSNAQSSLVQLIDIALGIQHIASGEVSDKTGKDQRTAFMKVTPLWSPFWSFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKT5</accession>
    <name>B8MKT5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_044010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484887.1">
        <property type="nucleotide sequence ID" value="XM_002484842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKT5"/>
    <dbReference type="GeneID" id="8097909"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_044010"/>
    <dbReference type="HOGENOM" id="CLU_2559865_0_0_1"/>
    <dbReference type="InParanoid" id="B8MKT5"/>
    <dbReference type="PhylomeDB" id="B8MKT5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="82" mass="9040" checksum="6B83096EF447A7CF" modified="2009-03-03" version="1">MSVVAVKEDRRGQAGRRHGGRQQGGKCGSGSAGTTKVNTQRHENKDNETSRNGDDETNENQIRRSKRRGHGQPAPWLGDENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKU9</accession>
    <name>B8MKU9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 20</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mediator complex subunit 20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MED20</name>
        <name evidence="6" type="ORF">TSTA_044150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the Mediator complex subunit 20 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484901.1">
        <property type="nucleotide sequence ID" value="XM_002484856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKU9"/>
    <dbReference type="STRING" id="441959.B8MKU9"/>
    <dbReference type="GeneID" id="8102714"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_044150"/>
    <dbReference type="eggNOG" id="ENOG502SBIU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075636_0_0_1"/>
    <dbReference type="InParanoid" id="B8MKU9"/>
    <dbReference type="OrthoDB" id="1854899at2759"/>
    <dbReference type="PhylomeDB" id="B8MKU9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013921">
        <property type="entry name" value="Mediator_Med20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08612">
        <property type="entry name" value="Med20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="272"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED14948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="337" mass="38425" checksum="A8432BA15C01EEE9" modified="2009-03-03" version="1">MPHTGVFFIPSSPNAPNIVGLLTERLRSVYSDEAIPIGRWVLEHKLMRDTPSCLPASAHAPNPAPKPRYVQFLSMTNYPKVGFIYASENVDGENPKTKTTTESGMIMSTVPNASSTEIFRHFVRCCEPIWCHRHSVSVTGAVYEVGDFRVRLGEVRQMQPHARPRGTIMEIEWKGPSMIAAALSTSFLDHDGSQIGNEMDIDGGIDSDMETPYIPTEAQIQLEYEQVSHLIKEFWTCIYNSNDSNNNKQLSAAAVQEAILIPDVGREVKQKIAQRRQPGWQEREKRRRKKRREAIALDRSWGGFSEKQQQQQDEEEEDIEGDVDLARQYMELFRFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MM82</accession>
    <name>B8MM82_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_098510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="335" mass="34899" checksum="BE1905701465B647" modified="2009-03-03" version="1">MTDRMSTPTLINLPPPPSDPVTPSDMGPGTPNSGTTSLSALSTTAIKDGHQGHPHPYGRHAHQSSSASATSTSTLEAERADRISRLAGLERIATARAGGGSQNVMSGMGSLTPTAVSGGYFTQQQQAYTPNTIASNNNNNNSSNNQQGYFDSYPQHLLKERSTVGSASATGSIGGRTTWASGSDAFDPDKMSEDRSSIGDDDDVDVDVDDRMSDEGNASLVGFGEGANSTISGPISTVSAGRLQSSSSSSNPRTSVFGSPTAGNRGVNSNVFAQQQQRQQQNLSPSPAGSNTPEPFDDARMVDGMTYDADVVDTTVRTPQLVGGLNDCDEQDSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MP64</accession>
    <name>B8MP64_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_105150</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486541.1">
        <property type="nucleotide sequence ID" value="XM_002486496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MP64"/>
    <dbReference type="FunCoup" id="B8MP64">
        <property type="interactions" value="1332"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MP64"/>
    <dbReference type="GeneID" id="8098736"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_105150"/>
    <dbReference type="eggNOG" id="ENOG502SJG4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007426_4_0_1"/>
    <dbReference type="InParanoid" id="B8MP64"/>
    <dbReference type="OMA" id="MCTLHRK"/>
    <dbReference type="OrthoDB" id="762982at2759"/>
    <dbReference type="PhylomeDB" id="B8MP64"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="247"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="544"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED14303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="621" mass="70290" checksum="0562009886272FF4" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPC4</accession>
    <name>B8MPC4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_105740</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486601.1">
        <property type="nucleotide sequence ID" value="XM_002486556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPC4"/>
    <dbReference type="STRING" id="441959.B8MPC4"/>
    <dbReference type="GeneID" id="8100433"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_105740"/>
    <dbReference type="eggNOG" id="KOG0159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_11_1"/>
    <dbReference type="InParanoid" id="B8MPC4"/>
    <dbReference type="OMA" id="MLGGCEA"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="PhylomeDB" id="B8MPC4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED14363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="517" mass="58537" checksum="5019B1D1F05307E3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPD4</accession>
    <name>B8MPD4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phenol 2-monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_105840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486611.1">
        <property type="nucleotide sequence ID" value="XM_002486566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPD4"/>
    <dbReference type="STRING" id="441959.B8MPD4"/>
    <dbReference type="GeneID" id="8100443"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_105840"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_9_2_1"/>
    <dbReference type="InParanoid" id="B8MPD4"/>
    <dbReference type="OMA" id="AYWMARC"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="PhylomeDB" id="B8MPD4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
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    </dbReference>
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    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
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    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
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            <end position="376"/>
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        <location>
            <begin position="412"/>
            <end position="624"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED14373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="630" mass="72150" checksum="88983CF38EF49403" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQ10</accession>
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        <name evidence="8" type="ORF">TSTA_054120</name>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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            <taxon>Ascomycota</taxon>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQ10"/>
    <dbReference type="STRING" id="441959.B8MQ10"/>
    <dbReference type="GeneID" id="8100351"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_054120"/>
    <dbReference type="eggNOG" id="ENOG502RXUE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003667_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQ10"/>
    <dbReference type="OMA" id="VQSYRTN"/>
    <dbReference type="OrthoDB" id="5377273at2759"/>
    <dbReference type="PhylomeDB" id="B8MQ10"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39469">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39469:SF1">
        <property type="entry name" value="DUF4203 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="TM7S3/TM198-like" evidence="7">
        <location>
            <begin position="55"/>
            <end position="233"/>
        </location>
    </feature>
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        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="324"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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    </feature>
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        </location>
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        <location>
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            <end position="491"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
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    </feature>
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        <location>
            <begin position="750"/>
            <end position="768"/>
        </location>
    </feature>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED12900.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1011" mass="110889" checksum="EC19367786E66C6A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQC4</accession>
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        <submittedName>
            <fullName evidence="4">Manganese ion homeostasis (Fr), putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">TSTA_058150</name>
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    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
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    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="AlphaFoldDB" id="B8MQC4"/>
    <dbReference type="FunCoup" id="B8MQC4">
        <property type="interactions" value="525"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MQC4"/>
    <dbReference type="GeneID" id="8109236"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_058150"/>
    <dbReference type="eggNOG" id="KOG3662">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011607_2_2_1"/>
    <dbReference type="InParanoid" id="B8MQC4"/>
    <dbReference type="OMA" id="TIQNHLC"/>
    <dbReference type="OrthoDB" id="5977743at2759"/>
    <dbReference type="PhylomeDB" id="B8MQC4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metallo-depent_PP-like"/>
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    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF4">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, ISOFORM E"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
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        <location>
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            <end position="542"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="563"/>
            <end position="582"/>
        </location>
    </feature>
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        <location>
            <begin position="601"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED13326.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="683" mass="76918" checksum="EE70311199FA3A0F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQH1</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">TSTA_058620</name>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
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    </reference>
    <dbReference type="EMBL" id="EQ962659">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQH1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_058620"/>
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    <dbReference type="InParanoid" id="B8MQH1"/>
    <dbReference type="OrthoDB" id="26838at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED13373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="160" mass="18131" checksum="0A8F7F13E3FF9B74" modified="2009-03-03" version="1">MAADTISTENSNRLARRIQKDVTASAALKASWQSTKRMSVGFTIRTKEVALMFPMNALSGQKSCNIVNKGCWRQMVRQATQELIKFSQCKNYDGKAKSKICGPWGSICIEQSIEDWNNEVIMEAGIVFDEDDHWRSEIKLRVKRLGRSLICIYGRASYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQH9</accession>
    <name>B8MQH9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS quinate transporter QutD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_058700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487492.1">
        <property type="nucleotide sequence ID" value="XM_002487447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQH9"/>
    <dbReference type="STRING" id="441959.B8MQH9"/>
    <dbReference type="GeneID" id="8106472"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_058700"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="InParanoid" id="B8MQH9"/>
    <dbReference type="OMA" id="FGRKWPW"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="PhylomeDB" id="B8MQH9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="24"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED13381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="532" mass="58603" checksum="008F99F330B2256B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQK8</accession>
    <name>B8MQK8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA interference and gene silencing protein (Qde2), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_058970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487521.1">
        <property type="nucleotide sequence ID" value="XM_002487476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQK8"/>
    <dbReference type="STRING" id="441959.B8MQK8"/>
    <dbReference type="GeneID" id="8106499"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_058970"/>
    <dbReference type="eggNOG" id="KOG1041">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004544_4_1_1"/>
    <dbReference type="InParanoid" id="B8MQK8"/>
    <dbReference type="OMA" id="RGRCYIH"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="PhylomeDB" id="B8MQK8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="2">
        <location>
            <begin position="682"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED13410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1038" mass="113538" checksum="B06A50180EBE15D7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-09-13" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQP0</accession>
    <name>B8MQP0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_059500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487574.1">
        <property type="nucleotide sequence ID" value="XM_002487529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQP0"/>
    <dbReference type="GeneID" id="8107419"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_059500"/>
    <dbReference type="HOGENOM" id="CLU_2759536_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQP0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED13463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="7586" checksum="C506CF970C84957E" modified="2009-03-03" version="1">MLMTTSRDPCAHSDEYRKAYDYAYTSQLHIREADPIISSKYDAIIVGGGTAGLVAGARLSEDGTKKDSCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8MR40</accession>
    <name>B8MR40_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosome biogenesis protein Sqt1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_054470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487046.1">
        <property type="nucleotide sequence ID" value="XM_002487001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MR40"/>
    <dbReference type="FunCoup" id="B8MR40">
        <property type="interactions" value="618"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MR40"/>
    <dbReference type="GeneID" id="8100385"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_054470"/>
    <dbReference type="eggNOG" id="KOG0296">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_9_1"/>
    <dbReference type="InParanoid" id="B8MR40"/>
    <dbReference type="OMA" id="SIWDYSK"/>
    <dbReference type="OrthoDB" id="10261640at2759"/>
    <dbReference type="PhylomeDB" id="B8MR40"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000643">
        <property type="entry name" value="60S ribosome biogenesis protein Sqt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF8">
        <property type="entry name" value="ANGIO-ASSOCIATED MIGRATORY CELL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="124"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED12935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="523" mass="54937" checksum="D9F3079936BC1818" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRA1</accession>
    <name>B8MRA1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_055030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487107.1">
        <property type="nucleotide sequence ID" value="XM_002487062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRA1"/>
    <dbReference type="GeneID" id="8100509"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_055030"/>
    <dbReference type="HOGENOM" id="CLU_2135217_0_0_1"/>
    <dbReference type="InParanoid" id="B8MRA1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="113" mass="12356" checksum="0780B89E24FBEFCF" modified="2009-03-03" version="1">MASESRGSTGKSSPSPVSLRSQQSKARLDPRPPNSVASYPIHHHFYPPKALNALPTPFSFHPGPFGPSLTVIFRRLCCPPNVATGRISSFDNAFAFAHIISRPILRLPIDPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRN2</accession>
    <name>B8MRN2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mediator of RNA polymerase II transcription subunit 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_056860</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 21 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487300.1">
        <property type="nucleotide sequence ID" value="XM_002487255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRN2"/>
    <dbReference type="STRING" id="441959.B8MRN2"/>
    <dbReference type="GeneID" id="8109917"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_056860"/>
    <dbReference type="eggNOG" id="KOG1510">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094271_0_1_1"/>
    <dbReference type="InParanoid" id="B8MRN2"/>
    <dbReference type="OMA" id="LTTYHDH"/>
    <dbReference type="OrthoDB" id="526653at2759"/>
    <dbReference type="PhylomeDB" id="B8MRN2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.10">
        <property type="entry name" value="Mediator complex, subunit Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021384">
        <property type="entry name" value="Mediator_Med21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381">
        <property type="entry name" value="RNA POLYMERASE II HOLOENZYME COMPONENT SRB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11221">
        <property type="entry name" value="Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="37"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="167"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED13189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="223" mass="23821" checksum="DA41C9F1F142EB2C" modified="2009-03-03" version="1">MADILTQLQTCLDQLATQFYATLCYLSTYHDHVPATVPPPSSGITDSMPPLAKIPRNQPSAAPMPAGAAAKQTAEQQGQTSPSLGISGAGGAAGGVGAETSTLPPGTNGATATTSLTPGQGDPNQPPIPDSPQLFLYRQKELARDLIIKEQQIEYLIGRLPGIGSSEAEQEARIRELESELRQVELAREKKAKELKKLGKRLESVLSTVERGIYSKQQRYGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8MS30</accession>
    <name>B8MS30_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_002720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="PhylomeDB" id="B8MS30"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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            <end position="1171"/>
        </location>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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            <dbReference type="PubMed" id="25676766"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <source>
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        <source>
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    </evidence>
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</entry>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
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</entry>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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        </source>
    </evidence>
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</entry>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="26" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED12387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="188" mass="21459" checksum="E0DD4D2CDB1F42D1" modified="2009-03-03" version="1">MASIEARIRSFNDEREKEHLHNYVYVGSYDVYNTNRHLLRALSHICPHQLFEVRGPLRCTNGDMHYENLAAEICPVTVVTVLELDYDTFHGHIKYQKGHFHQRAGASNALSATSIFKIPQNTMLSNCHKMVQNRPWTLIPETSNVSRILYRDQSETGFALRSGATGQAFENAPGLSQTDLMERNLKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTI2</accession>
    <name>B8MTI2_TALSN</name>
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        <submittedName>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <comment type="function">
        <text evidence="2">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_004370"/>
    <dbReference type="eggNOG" id="KOG2020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003712_0_0_1"/>
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    <dbReference type="OMA" id="IAKRSWG"/>
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    <dbReference type="PhylomeDB" id="B8MTI2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:RNA nuclear export complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
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        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
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        <property type="entry name" value="Exportin-5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
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        <property type="entry name" value="Exportin-5"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF08389">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
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        <location>
            <begin position="108"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-5 C-terminal" evidence="5">
        <location>
            <begin position="331"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1005"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED12388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1236" mass="140420" checksum="05B2189585BE4DBF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTK9</accession>
    <name>B8MTK9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_004610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488069.1">
        <property type="nucleotide sequence ID" value="XM_002488024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTK9"/>
    <dbReference type="STRING" id="441959.B8MTK9"/>
    <dbReference type="ESTHER" id="talsn-b8mtk9">
        <property type="family name" value="Canar_LipB"/>
    </dbReference>
    <dbReference type="GeneID" id="8104445"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_004610"/>
    <dbReference type="eggNOG" id="ENOG502QSW8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029537_3_0_1"/>
    <dbReference type="InParanoid" id="B8MTK9"/>
    <dbReference type="OMA" id="TFYPETR"/>
    <dbReference type="OrthoDB" id="4605274at2759"/>
    <dbReference type="PhylomeDB" id="B8MTK9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053228">
        <property type="entry name" value="Stereospecific_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37574">
        <property type="entry name" value="LIPASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37574:SF1">
        <property type="entry name" value="LIPASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012836099" evidence="1">
        <location>
            <begin position="16"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="353" mass="39628" checksum="5DE55E8504A6222C" modified="2009-03-03" version="1">MLALLLLPTISFALAAIWLGASVREKRLVYHKNNVTFTGPDPVYLVDERQLDEAVSCPSSRPQAKGTVLLVHGTGMAPQINWEYTLVPPLIHEGFRPCYVAVPHRLFDDAQISAEYISHAIKKLADKNDTQISIISWSAGALITQWTLTFYPETRSKVKRHIALGPDYRGSWSMVPLFYFNMFTEAVVQQIPWSNFLNTLNRFGGDIARVPTTNIGSSTDLIVQPGFYGEGWPMFKDSWRLNGPQARNIDLFKLCAAKSLMHRALPHVVSHDSLLWEPASHQIIFDALNNEETYVGSADSVTFDHCRGGQANHLPPGSETRHSEIMPELVDYASKMPVKGWPEVPLRDYALLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8MU47</accession>
    <name>B8MU47_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Allergenic cerato-platanin Asp F13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_006970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cerato-platanin family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488334.1">
        <property type="nucleotide sequence ID" value="XM_002488289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MU47"/>
    <dbReference type="GeneID" id="8106830"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_006970"/>
    <dbReference type="eggNOG" id="ENOG502SQTH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111635_0_0_1"/>
    <dbReference type="InParanoid" id="B8MU47"/>
    <dbReference type="OMA" id="CHRLEYG"/>
    <dbReference type="OrthoDB" id="4898945at2759"/>
    <dbReference type="PhylomeDB" id="B8MU47"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22778">
        <property type="entry name" value="DPBB_CEPL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010829">
        <property type="entry name" value="Cerato-platanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07249">
        <property type="entry name" value="Cerato-platanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002875519" evidence="4">
        <location>
            <begin position="21"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED12680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="138" mass="14550" checksum="15A9FEE36DC4B88D" modified="2009-03-03" version="1">MKITTFHAALFTLSASGALAANTTETTLATFDTAYDDANLSLSTVTCSNGENGLVTKGYNTISDLPTQDVAGSLTVKGWNDVNCGACYSLSYKNETVYVLAIDSAIGQFNVAQKVLDKLTHGQAQEFGSVSVDYEQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUQ0</accession>
    <name>B8MUQ0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_109090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488486.1">
        <property type="nucleotide sequence ID" value="XM_002488441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUQ0"/>
    <dbReference type="GeneID" id="8103237"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109090"/>
    <dbReference type="eggNOG" id="ENOG502RZDV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_8_0_1"/>
    <dbReference type="InParanoid" id="B8MUQ0"/>
    <dbReference type="OMA" id="MTIICDS"/>
    <dbReference type="OrthoDB" id="5283415at2759"/>
    <dbReference type="PhylomeDB" id="B8MUQ0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="35"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="299"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED11730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="336" mass="37239" checksum="F1F6A5FFC1EEC911" modified="2009-03-03" version="1">MASRLSPEYLAQDRRPQARIGISVVTVLSGIVVLVRVYARCKIIRSFGYDDGLICVAMLINIAIMALTFQVLRYGAGLHIASLSASDVPYLYKWLVSAQLAYMLALWLCRLSGIAFYQRLNPRTGPYSLILKLSIAFVTSIFITQTLIIALQCIPLSALWGATKGKCIGSKAVFYSTASMTIICDSLILLLPIYIIFTIQANLTRKVALASVMCFGIFTSICRILAMIPAIEDSDATWYFSVVMVWSDTEVSTAIIALSLPALKGLFSGMRNKRKALSEDGRYGTLTEDRKMENFNRFRHEGNQPSDFYGGRTSERDSSGVVGNNPSDEALWREDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8MVB1</accession>
    <name>B8MVB1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_008630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962662">
        <property type="protein sequence ID" value="EED11567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488748.1">
        <property type="nucleotide sequence ID" value="XM_002488703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MVB1"/>
    <dbReference type="STRING" id="441959.B8MVB1"/>
    <dbReference type="GeneID" id="8103251"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_008630"/>
    <dbReference type="eggNOG" id="ENOG502S3BW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_288388_0_0_1"/>
    <dbReference type="InParanoid" id="B8MVB1"/>
    <dbReference type="OMA" id="QAFANFW"/>
    <dbReference type="OrthoDB" id="4369803at2759"/>
    <dbReference type="PhylomeDB" id="B8MVB1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="3">
        <location>
            <begin position="355"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6570" evidence="3">
        <location>
            <begin position="414"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="2">
        <location>
            <begin position="572"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="295"/>
        </location>
    </feature>
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        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED11567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1066" mass="123053" checksum="ED7D5BA468446AA9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MVG0</accession>
    <name>B8MVG0_TALSN</name>
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        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_007580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962663">
        <property type="protein sequence ID" value="EED11468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002488739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MVG0"/>
    <dbReference type="GeneID" id="8103287"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_007580"/>
    <dbReference type="HOGENOM" id="CLU_633367_0_0_1"/>
    <dbReference type="InParanoid" id="B8MVG0"/>
    <dbReference type="OrthoDB" id="4363438at2759"/>
    <dbReference type="PhylomeDB" id="B8MVG0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="204"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="408"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED11468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="433" mass="48893" checksum="29A5D48118CACC34" modified="2009-03-03" version="1">MDLADFSEILDEQLARDFIKASEDILSKFHKTWTNKLMEFNLGIESSILLKEPQFDEALRSVKEELQKKNKDKKKTGSSTDTKKNSENQESANLVYNSDEFVGLLNDTKPPVLQSVVSTVLSASGRNADLWDKTLYDTGATAHITNNQERLINIQLNIRIIQTGKIEIKMISHDNPLSEQAPGAWNQKCEVCELTKAQKKISRVSMTPPTRPFQVLFVNIIVMNMAINKDLYALHAVDLYTKFHALVTTRMKSVNFDLETLIEQIEHTFKTKVDEIHMDGESSLNGISFKEYCHKQKIKLIVTVPYTLEQNGPSERAGGIITMKSQSLSKVYVKINTKKSDKMALRAQIGFLKYNPDHPFAKEIVKEGITKYVGNIDIPNINKADPNIVFDSVDDDMRLQQFSVSLGKTMTGGSTSPHEHANIEQPTQPLDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8LT00</accession>
    <name>B8LT00_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Siderophore transcription factor SreA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_064620</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340383.1">
        <property type="nucleotide sequence ID" value="XM_002340342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LT00"/>
    <dbReference type="STRING" id="441959.B8LT00"/>
    <dbReference type="GeneID" id="8106659"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_064620"/>
    <dbReference type="eggNOG" id="KOG1601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021761_1_0_1"/>
    <dbReference type="InParanoid" id="B8LT00"/>
    <dbReference type="OMA" id="CYRPTTM"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="PhylomeDB" id="B8LT00"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034757">
        <property type="term" value="P:negative regulation of iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000039">
        <property type="entry name" value="Siderophore transcription factor SreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="12">
        <location>
            <begin position="100"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="12">
        <location>
            <begin position="256"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="141"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="217"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="310"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="217"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="423"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED22996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="493" mass="53054" checksum="C17FE9AEA09B2051" modified="2009-03-03" version="1">METVPSLTLERKLDTTPVRSGEDLDAARQLISSARGMRPILAFPQQDRVLPNGNEDWQSTNKPAMSDTMDMMPDQTTLEVDRIMSRGPQRSPKPLGRDTAFLGHSCSNCGTKSTPLWRRSPTGATICNACGLYLKARNVHRPTKRNRNRPQITTPGPNSDSHSASPDPTTAPVQSGCGSGSTGSCPGGGNCNGTGGAEGCDGCPAYNNRLFKSTARVSSQPLQAQPTGETEQPPNSSGADSNVPSAENGGDLLVACQNCGTTVTPLWRRDENGHPICNACGLYYKLHGCYRPTTMKKSIIKRRKRVVPAMRDHSPGFGTQSEGESSASPEAHPARLTHGLDRPMLAPPPVDFTGYNMSAAATLPHHPGPRLPELQSTFQRQSHSPGAASVTRDGDTLPPIESSNQLPPIMSQMHPTQPARLSPISSILNPGANPANTNKMPPGDGYRHSQSPPIPSPGQSDAYKYERRVQLQREAELMREALKAKERELAELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8LU03</accession>
    <name>B8LU03_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Chorismate synthase</fullName>
            <ecNumber evidence="4 8">4.2.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_072260</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the chorismate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341220.1">
        <property type="nucleotide sequence ID" value="XM_002341179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LU03"/>
    <dbReference type="FunCoup" id="B8LU03">
        <property type="interactions" value="257"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LU03"/>
    <dbReference type="GeneID" id="8102306"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_072260"/>
    <dbReference type="eggNOG" id="KOG4492">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034547_0_1_1"/>
    <dbReference type="InParanoid" id="B8LU03"/>
    <dbReference type="OMA" id="MLSINAV"/>
    <dbReference type="OrthoDB" id="1721239at2759"/>
    <dbReference type="PhylomeDB" id="B8LU03"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.150.10:FF:000004">
        <property type="entry name" value="Chorismate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="entry name" value="Chorismate synthase AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003793">
        <property type="entry name" value="PRK05382.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085:SF0">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="Chorismate synthase, AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED23833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="411" mass="44088" checksum="1F89EEE33CE94D27" modified="2009-03-03" version="1">MSTWGDYFRVTTYGESHCRSVGCIVDGCPPGMALTEDDIQPQMTRRRPGQSALTTPRNEKDRVEIQSGTECGYTLGTPIAMIVRNEDQRPKDYGGSTMDLYPRPSHADYTYLEKYGVKASSGGGRSSARETIGRVAAGAIAEKYLKLAHNVEIVSFVSSVGNEHLFPPSAEHPSYSTNPEFLKLIETIDRETVDKFAPVRCPSTEASERMTKVIETFRDNHDSIGGTVMCVIRNVPIGLGEPAFDKLEAKLGHAMMSIPATKGFEIGSGFGGCEVPGSIHNDPFVAAPEVSENKPGAGIANKSRLTTSSNNSGGIQGGISNGATIYFRTAFKPPATIGQAQTTTTYALEEGILEAKGRHDPCVVPRAVPIVEAMAALVVMDALLAQKAREASRSLLPPLPKGLPIKPETSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8LU54</accession>
    <name>B8LU54_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dynamin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_060230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002339913.1">
        <property type="nucleotide sequence ID" value="XM_002339872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LU54"/>
    <dbReference type="STRING" id="441959.B8LU54"/>
    <dbReference type="GeneID" id="8106070"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_060230"/>
    <dbReference type="eggNOG" id="KOG0446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008964_7_2_1"/>
    <dbReference type="InParanoid" id="B8LU54"/>
    <dbReference type="OMA" id="ERYGHEY"/>
    <dbReference type="OrthoDB" id="4219983at2759"/>
    <dbReference type="PhylomeDB" id="B8LU54"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001425">
        <property type="entry name" value="Dynamin GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF215">
        <property type="entry name" value="DYNAMIN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="3">
        <location>
            <begin position="32"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED22526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="561" mass="63450" checksum="C9425F6B2FAD8B0A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8LU94</accession>
    <name>B8LU94_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_060580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002339953.1">
        <property type="nucleotide sequence ID" value="XM_002339912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LU94"/>
    <dbReference type="STRING" id="441959.B8LU94"/>
    <dbReference type="GeneID" id="8110197"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_060580"/>
    <dbReference type="eggNOG" id="ENOG502STRK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034865_0_0_1"/>
    <dbReference type="InParanoid" id="B8LU94"/>
    <dbReference type="OMA" id="CVFSPRQ"/>
    <dbReference type="OrthoDB" id="4222117at2759"/>
    <dbReference type="PhylomeDB" id="B8LU94"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="133"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED22566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="498" mass="55201" checksum="D602B54625E05BAA" modified="2009-03-03" version="1">MGSRRTTAAGSNTQPLRIEVDNPTLRKPCTAAATASAAQVSSYSLVLPPPFLPTSMHRAYTHHELIKLAPTFTRAVHSVTRFLCRVTMPNPVQRSACDRCHGQKLRCSRSGHGGPCIRCTKVQAVCTWTPSTRRQSEHLSSKPPNLQESSIATLGSSPTYDDGHGIESMTPLNTSFPTVQTEFDFSALSTCPLPDNPTTATWSCPTFVDLVSGFSSTCALSNASPTADPYLQSGDAASTWQYRFNQEWAMLSAEQQSPPNDGIVRTCPGTHRAKSQETQNLRLSTIRKLSDLNVEMFTLSSTIPKPPTSISQPHSWKNKDFAIDKTFQLSQRLIEVLDKLYPRNSESNSYIMTRLQEDALPVLAPNDSPSFDQSSFLLVLSCYQRLIETYHDIFGNMQACLDRSMVTAREDYVQMPDMKVGSFSVPDSSALQITMILQLSRHLLRRMGTIIKSLKTNYNGSGTNDLMSLTFNAVNTREDELIETINKLRNSLLSLDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUR9</accession>
    <name>B8LUR9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcofluor white hypersensitive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_073160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341313.1">
        <property type="nucleotide sequence ID" value="XM_002341272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUR9"/>
    <dbReference type="GeneID" id="8106035"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_073160"/>
    <dbReference type="eggNOG" id="ENOG502SSX2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129945_0_0_1"/>
    <dbReference type="InParanoid" id="B8LUR9"/>
    <dbReference type="OMA" id="KHQMRID"/>
    <dbReference type="OrthoDB" id="5355126at2759"/>
    <dbReference type="PhylomeDB" id="B8LUR9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED23926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="14543" checksum="F957531C7CDE342F" modified="2009-03-03" version="1">MSKSRLPLYLGLTAAGAGGYYLYKSGGDVDGAAQRAKADAEKARAKLPGTNEPAAKGEEIGARATAKLDEIVDSAHAKAKDANSRFGEGAKESLEKIERIRQDTAKQMGTTVDKLDRKVEEKAAEAKKSITSWFGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8LW40</accession>
    <name>B8LW40_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-splicing factor CLF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pre-mRNA-splicing factor clf1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_074460</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341455.1">
        <property type="nucleotide sequence ID" value="XM_002341414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LW40"/>
    <dbReference type="FunCoup" id="B8LW40">
        <property type="interactions" value="1054"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LW40"/>
    <dbReference type="GeneID" id="8101210"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_074460"/>
    <dbReference type="eggNOG" id="KOG1915">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011554_1_0_1"/>
    <dbReference type="InParanoid" id="B8LW40"/>
    <dbReference type="OMA" id="HIKVWIS"/>
    <dbReference type="OrthoDB" id="541719at2759"/>
    <dbReference type="PhylomeDB" id="B8LW40"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000048">
        <property type="entry name" value="Cell cycle control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000306">
        <property type="entry name" value="Cell cycle control protein cwf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000269">
        <property type="entry name" value="Crooked neck pre-mRNA-splicing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059164">
        <property type="entry name" value="HAT_PRP39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF3">
        <property type="entry name" value="CROOKED NECK-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23241">
        <property type="entry name" value="HAT_PRP39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="12">
        <location>
            <begin position="60"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="12">
        <location>
            <begin position="308"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED24068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="673" mass="81346" checksum="B9C0A21B0DEEC4F3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXI4</accession>
    <name>B8LXI4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">YagE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_078440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341872.1">
        <property type="nucleotide sequence ID" value="XM_002341831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXI4"/>
    <dbReference type="GeneID" id="8101186"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_078440"/>
    <dbReference type="eggNOG" id="KOG2861">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011220_3_0_1"/>
    <dbReference type="InParanoid" id="B8LXI4"/>
    <dbReference type="OMA" id="EWHGART"/>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="PhylomeDB" id="B8LXI4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF4">
        <property type="entry name" value="SPORULATION PROTEIN RMD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="803"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="412"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED24485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1030" mass="115292" checksum="1A2CF5330C465995" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXX4</accession>
    <name>B8LXX4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_062760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340176.1">
        <property type="nucleotide sequence ID" value="XM_002340135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXX4"/>
    <dbReference type="STRING" id="441959.B8LXX4"/>
    <dbReference type="GeneID" id="8106628"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_062760"/>
    <dbReference type="eggNOG" id="KOG3043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_0_0_1"/>
    <dbReference type="InParanoid" id="B8LXX4"/>
    <dbReference type="OMA" id="FGFHPHV"/>
    <dbReference type="OrthoDB" id="2147163at2759"/>
    <dbReference type="PhylomeDB" id="B8LXX4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668:SF1">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G01940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="260" mass="28475" checksum="495D2B1D5B10BF16" modified="2009-03-03" version="1">MASTYSNACCETPVPHNVADYQAQGEWLDILGEKVYVVGDKAANRAIVWVFDIFGYSPQTLRGADVVAANLLSSSKGPVTVLIPDWFDGTVADKAWVPPVTDDQAAKLGNFIKTKAAPELVVPRVLKFAEALKQHQTILPNIQNLGIFGFCWGGKLASIACQKSSDGVFAVAVQTSPSKADPEEARNISVPMALILSKDEDLPTMKRFYDNIPTPYKLLERFDDQIHGFMSGRGDLSDPGVKAEVERGYNQAVEFFDKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8LY71</accession>
    <name>B8LY71_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Extracellular conserved serine-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_067510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340702.1">
        <property type="nucleotide sequence ID" value="XM_002340661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LY71"/>
    <dbReference type="STRING" id="441959.B8LY71"/>
    <dbReference type="GeneID" id="8109460"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_067510"/>
    <dbReference type="eggNOG" id="ENOG502S7YR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088618_3_0_1"/>
    <dbReference type="InParanoid" id="B8LY71"/>
    <dbReference type="OMA" id="SFDIYLV"/>
    <dbReference type="OrthoDB" id="5316007at2759"/>
    <dbReference type="PhylomeDB" id="B8LY71"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052479">
        <property type="entry name" value="GPI-anchor_Adhesion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185">
        <property type="entry name" value="SERINE/THREONINE-RICH PROTEIN ADG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185:SF1">
        <property type="entry name" value="UPF0619 GPI-ANCHORED MEMBRANE PROTEIN C1322.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002874583" evidence="3">
        <location>
            <begin position="18"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="22"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED23315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="208" mass="21018" checksum="256F677E02D0CAC9" modified="2009-03-03" version="1">MQIKLGTALMLATSASALQVTSPSRGDKWDLTHSNEVTWDSVESDPTSFDIQLVNEHVNPPVVKTIATNVQTSAGSYSFSNVAVDIGDDYQINLVSTEAHNTGILAQSAQFDVSNAASNNSSSSTSTASSTSTTSSSSSSSSTTASTATTTSSSSASSSEIRTSSSKTASLTSTSTSPSVSATHTGAAATVPVSVLGCIMGSVLALLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYH0</accession>
    <name>B8LYH0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">magnesium chelatase</fullName>
            <ecNumber evidence="1">6.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_063750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism.</text>
    </comment>
    <dbReference type="EC" id="6.6.1.1" evidence="1"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340286.1">
        <property type="nucleotide sequence ID" value="XM_002340245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYH0"/>
    <dbReference type="GeneID" id="8101068"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_063750"/>
    <dbReference type="eggNOG" id="ENOG502QQMN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034390_0_0_1"/>
    <dbReference type="InParanoid" id="B8LYH0"/>
    <dbReference type="OMA" id="HWHDPED"/>
    <dbReference type="OrthoDB" id="5582146at2759"/>
    <dbReference type="PhylomeDB" id="B8LYH0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016851">
        <property type="term" value="F:magnesium chelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.80">
        <property type="entry name" value="Magnesium chelatase subunit I, C-Terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052041">
        <property type="entry name" value="Nucleic_acid_metab_PIN/TRAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11603">
        <property type="entry name" value="AAA FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11603:SF132">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ChlI/MoxR AAA lid" evidence="3">
        <location>
            <begin position="255"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED22899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="349" mass="39000" checksum="04B8504AF4F87E3D" modified="2009-03-03" version="1">MDAFVIQDLVSELTDLELAILLALICQGHCVIETPVVNVDDVAGELALICQNRFGLSYAVLDCSSRTSIDNFSNSILVSDAKRGRSSNALPSFQTGGQFDERKIVNVVIAKNFHKVSSDIQIQALELIRSKRIFTRTSIHITQKTFLFVPLIGYDDIVQRTVRLNKHLNDFFLFSHFHEIDAGLPNLEGDEGWPSDDQASVSSVVRKSQRYNDHFHTNNRQVPEQMILHLRLLSDAVSVSAEVNRYLHNIVVFLRLNRAVAGGVSAKATKYFMIVAKSLASMHGINYLTPSVVCLAAKKVYRHRIIVAKPEDDRSLQYGSHLSSVTMILKDIDPDQIIDAVISEVEVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYJ5</accession>
    <name>B8LYJ5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TSTA_067820</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">MAP4K component of the MAPK pathway required for the mating pheromone response and the regulation of cell polarity and cell cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340740.1">
        <property type="nucleotide sequence ID" value="XM_002340699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYJ5"/>
    <dbReference type="FunCoup" id="B8LYJ5">
        <property type="interactions" value="386"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LYJ5"/>
    <dbReference type="GeneID" id="8102432"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_067820"/>
    <dbReference type="eggNOG" id="KOG0578">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_26_1_1"/>
    <dbReference type="InParanoid" id="B8LYJ5"/>
    <dbReference type="OMA" id="MVDIMKF"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="PhylomeDB" id="B8LYJ5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008349">
        <property type="term" value="F:MAP kinase kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071470">
        <property type="term" value="P:cellular response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001402">
        <property type="term" value="P:signal transduction involved in filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000011">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000385">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000007">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="19">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="565"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="150"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="330"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="473"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="594"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EED23353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="846" mass="93845" checksum="5B4B36EFA8EE0D2D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYM6</accession>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340771.1">
        <property type="nucleotide sequence ID" value="XM_002340730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYM6"/>
    <dbReference type="STRING" id="441959.B8LYM6"/>
    <dbReference type="GeneID" id="8107372"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_068110"/>
    <dbReference type="eggNOG" id="KOG0502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027083_0_0_1"/>
    <dbReference type="InParanoid" id="B8LYM6"/>
    <dbReference type="OMA" id="MATISDG"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="PhylomeDB" id="B8LYM6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="6"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="4">
        <location>
            <begin position="162"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="378"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="411"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="444"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="477"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="546"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="576"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="609"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED23384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="680" mass="76738" checksum="C81B261A1E21D4DB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYV0</accession>
    <name>B8LYV0_TALSN</name>
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        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_068830</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340845.1">
        <property type="nucleotide sequence ID" value="XM_002340804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYV0"/>
    <dbReference type="STRING" id="441959.B8LYV0"/>
    <dbReference type="GeneID" id="8107334"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_068830"/>
    <dbReference type="eggNOG" id="KOG0684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018012_2_1_1"/>
    <dbReference type="InParanoid" id="B8LYV0"/>
    <dbReference type="OMA" id="HEHISAF"/>
    <dbReference type="OrthoDB" id="3366823at2759"/>
    <dbReference type="PhylomeDB" id="B8LYV0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11040">
        <property type="entry name" value="CYP7_CYP8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="524"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED23458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="586" mass="66770" checksum="EF2ADC7DFF55F085" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZN6</accession>
    <name>B8LZN6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_097080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479422.1">
        <property type="nucleotide sequence ID" value="XM_002479377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZN6"/>
    <dbReference type="STRING" id="441959.B8LZN6"/>
    <dbReference type="GeneID" id="8109489"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_097080"/>
    <dbReference type="HOGENOM" id="CLU_488502_0_0_1"/>
    <dbReference type="InParanoid" id="B8LZN6"/>
    <dbReference type="OrthoDB" id="4368291at2759"/>
    <dbReference type="PhylomeDB" id="B8LZN6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="332"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="558" mass="62901" checksum="8944B40273C69031" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8M028</accession>
    <name>B8M028_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Penicillopepsin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_081930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477923.1">
        <property type="nucleotide sequence ID" value="XM_002477878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M028"/>
    <dbReference type="STRING" id="441959.B8M028"/>
    <dbReference type="GeneID" id="8104831"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_081930"/>
    <dbReference type="HOGENOM" id="CLU_013253_0_3_1"/>
    <dbReference type="InParanoid" id="B8M028"/>
    <dbReference type="OrthoDB" id="4226189at2759"/>
    <dbReference type="PhylomeDB" id="B8M028"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF1">
        <property type="entry name" value="ASPARTYL PROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED20960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="338" mass="37506" checksum="86E176EE8E3F3E0B" modified="2009-03-03" version="1">MGIIEIGSPAQTIDVQFDTTFNGVLVRSTRENPTDIDGILVYNSSGSRSWGYIYNSIPENTYTQTFEDDAYAIAFAGTETFNIGGKLYSDIAFGQLEQYYPNTSGQAIPFGGTSGIIGLNYNSMQQPLFPSFMYAIQDQLMEWKCSLNSSREWQNGTWILGSLESLDDRAAIAWADRNIDQPTWSVNVSAVSAGSRKNPPISTWSATVSTAEQSLVWPQKLLDWYFSGIDSTWSAFDNTYRYPCNASLPDFIFSIGNGTFTIPGTYMPYQRDPTSTTCISIITGDNSTDSSHEYTFGSWWAQLGVLILDYEHSQVGFMNKSTPLPKFTTAALDIIAMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0F0</accession>
    <name>B8M0F0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_084780</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478210.1">
        <property type="nucleotide sequence ID" value="XM_002478165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0F0"/>
    <dbReference type="STRING" id="441959.B8M0F0"/>
    <dbReference type="GeneID" id="8106084"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_084780"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_1_1"/>
    <dbReference type="InParanoid" id="B8M0F0"/>
    <dbReference type="OMA" id="HQAPKSH"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="PhylomeDB" id="B8M0F0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED21247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="530" mass="59632" checksum="FB744FE94874E2E4" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0T2</accession>
    <name>B8M0T2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="17">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">TSTA_086980</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="17"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478428.1">
        <property type="nucleotide sequence ID" value="XM_002478383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0T2"/>
    <dbReference type="FunCoup" id="B8M0T2">
        <property type="interactions" value="823"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M0T2"/>
    <dbReference type="GeneID" id="8110104"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_086980"/>
    <dbReference type="eggNOG" id="KOG1131">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011312_1_0_1"/>
    <dbReference type="InParanoid" id="B8M0T2"/>
    <dbReference type="OMA" id="WQTMGIL"/>
    <dbReference type="OrthoDB" id="272481at2759"/>
    <dbReference type="PhylomeDB" id="B8M0T2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000135">
        <property type="entry name" value="DNA repair helicase RAD3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000128">
        <property type="entry name" value="Putative DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000381">
        <property type="entry name" value="TFIIH basal transcription factor complex helicase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 22" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="21">
        <location>
            <begin position="7"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="745"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="248"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="745"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="780"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EED21465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="795" mass="90720" checksum="20E06CF1CD05E1B9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0V4</accession>
    <name>B8M0V4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Serine/threonine protein kinase (Kin28), putative</fullName>
            <ecNumber evidence="16">2.7.11.23</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSTA_089710</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.23" evidence="16"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478697.1">
        <property type="nucleotide sequence ID" value="XM_002478652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0V4"/>
    <dbReference type="FunCoup" id="B8M0V4">
        <property type="interactions" value="1058"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M0V4"/>
    <dbReference type="GeneID" id="8108060"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_089710"/>
    <dbReference type="eggNOG" id="KOG0659">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_6_1"/>
    <dbReference type="InParanoid" id="B8M0V4"/>
    <dbReference type="OMA" id="CLESEYF"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="PhylomeDB" id="B8M0V4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07841">
        <property type="entry name" value="STKc_CDK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000670">
        <property type="entry name" value="Serine/threonine protein kinase (Kin28)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037770">
        <property type="entry name" value="CDK7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF0">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="62"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="357"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="373"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="68"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED21734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="401" mass="44669" checksum="18B5264738761EAA" modified="2009-03-03" version="1">MAVSPLISQSPSSASVSTSTASKAKSLAVRSESQSATASHLNNATAALELAEQMNENVRRKYVKDNKLGEGTYAVVYLGHLRDTPSSLVAIKKIKVNAEYRDGLSMDAIREIKYLQELSHPNIIALHDVFSSKDQNLNLVLEYLPLGDLEMLIKDGNIQYGVADVKAWMGMLARGVWFCHENFVLHRDIKPNNLLIASDGEVKLADFGLARSFADPYMNMTHQVITRWYRPPELLYGARQYSAVVDVWSMGMVFAELLLRVPFVAGNTDMDQIAKISEAFGTPTEENWPGVTRLPNYVPPGDRITPLQGREFFLRQFPTAGPLGADLLMSMTTLDPCKRSSVRQILQHAWWMSEPKPTFKESLPRKSGGSKKMGNDLSRRAGEDSEGRFKNAARQLDFGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1Z9</accession>
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        </submittedName>
    </protein>
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        <name evidence="9" type="ORF">TSTA_086080</name>
    </gene>
    <organism evidence="9 10">
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
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            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
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    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
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    <dbReference type="HOGENOM" id="CLU_010778_2_1_1"/>
    <dbReference type="InParanoid" id="B8M1Z9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sodium/glucose cotransporter"/>
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        </source>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED21377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="670" mass="72758" checksum="2D821782A5132B64" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2U3</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">TSTA_094440</name>
    </gene>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <dbReference type="NCBI Taxonomy" id="441959"/>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
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            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    <dbReference type="GeneID" id="8103772"/>
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    <dbReference type="eggNOG" id="ENOG502SPJ5">
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    </dbReference>
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    </dbReference>
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            <end position="125"/>
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        <location>
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            <end position="571"/>
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        <source>
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        <source>
            <dbReference type="EMBL" id="EED22198.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="654" mass="71952" checksum="8F9FF9271004F1EB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3L4</accession>
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        </source>
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        <subcellularLocation>
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    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED22386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="510" mass="54955" checksum="E3A2EF90AC7126B9" modified="2009-03-03" version="1">MAEMDKKQPSLSESLGAPVETSVEKGIVSGGNDNDLLAQLGYKQELRRHYSTTQVFAIAFSIMALLPSIASTLSFSIPAGPVGMTWADLASAMPTAGGLYFWTHYFANEKWRNPLSFVVGYSNTLGLVGGLCSIDYGFALMLLSLVSIARDGEWSASRPVIYGTYVATVCVHGLMATFMGRIMNRIQTICIVLNVGLVVATVIALPIGNKHNGVPINSGSYVFGDVENLTTWPAGWAFVLAWLSPIWTIGAFDSCVHMSEEATHAARAVPIGIILSIGLCGLLGFLSLAVMAACMDKNLTNILGSAFGQPMAQIYYDSLGKSGALGFMAVVASVQFFMGLSILIAASRQTWAFSRDGALPFSDFFRHVSKRIQYQPIRTVWGSAFIAILIGLLTLINAAASNALFSLAVAGNDLAWGVPILCRLIWGDKTGKFRPGEFYTGWLSKPIAIVAVAYLFFAIILSMFPTGGPDPTADNMNYTIVINSFLWVGAALYYFLFAKKWYTGPKSTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3Q0</accession>
    <name>B8M3Q0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="5">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TSTA_038490</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
            <dbReference type="Rhea" id="RHEA:13289"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.7.8.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.15" evidence="5"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481077.1">
        <property type="nucleotide sequence ID" value="XM_002481032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3Q0"/>
    <dbReference type="FunCoup" id="B8M3Q0">
        <property type="interactions" value="505"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M3Q0"/>
    <dbReference type="GeneID" id="8107891"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_038490"/>
    <dbReference type="eggNOG" id="KOG2788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029942_1_0_1"/>
    <dbReference type="InParanoid" id="B8M3Q0"/>
    <dbReference type="OMA" id="LPHFNAR"/>
    <dbReference type="OrthoDB" id="10262326at2759"/>
    <dbReference type="PhylomeDB" id="B8M3Q0"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06855">
        <property type="entry name" value="GT_GPT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EED20643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="466" mass="51896" checksum="C4B1540D2AF9A054" modified="2009-03-03" version="1">MAPSTALSATEVYTLWVLIGTSIAIVANSFHGDGEPLMVSFAFSLFAFASTFSLIRWLGPSFMKVGLKGRDMAKAKRPEIPETMGAVCAVVYLLLMIAFIPFPFYKDIVAATSGGGNRDVVLHVEHVETGRFLHRFPHNKLASYLSGLLSLQAITLLGIGDDLLDIRWRHKVLIPALGAFPMLVVYFVDFGVTHVVVPVPLQRYFGQIFDLGFLYYVYMAAVAIFCPNSINMLAGINGVEVAQSLVIAVLLLLNDFLYLSPFTPYPHPAMDSHLFSIYFLLPFIGVSLALLCHNWYPSKVFVGDTYCYFAGMVFAVVGILGHFSKTLLLLFIPQMFNFLYSCPQLFHIIPCPRHRLPKFNAVTGLLENSVTEWTVPPSPLIAAALHLLHRLRLVGIKTNENGDIVESTNLTLLNLWILWFGPMKEDRLALSIVLLQTVCGLFALFARHQMALLVFPADNRSLWSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8M458</accession>
    <name>B8M458_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_039950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481235.1">
        <property type="nucleotide sequence ID" value="XM_002481190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M458"/>
    <dbReference type="STRING" id="441959.B8M458"/>
    <dbReference type="GeneID" id="8109754"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_039950"/>
    <dbReference type="HOGENOM" id="CLU_002055_1_1_1"/>
    <dbReference type="InParanoid" id="B8M458"/>
    <dbReference type="OMA" id="MINITPF"/>
    <dbReference type="OrthoDB" id="411592at2759"/>
    <dbReference type="PhylomeDB" id="B8M458"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="281" mass="31736" checksum="074479EEDBCC0707" modified="2009-03-03" version="1">MQTNDTLILTDNTFANREKNEIKQANILCKPQEKLTPSNLLKFNGGLITEDAQAKDDFKSLNKRLQWQLDNAERRLRFVRLDLDSLHLIIFADSSFANNKDFSSQIGFIIVLADGANNANIVHWSSIKCKRVTRSVLTSELYAMVHGFDSAASIKSTTTQLLHLTKPLPLVICTDSKSLYECLVKLGTTQEKRLMIDLMCLRQSYEHQEIAEIKWIDGESNLADIMIKSNPCRALQALINTNKLNINVDGWVERSTTPLTQYTPIPSPHQSCTAHYTVPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>B8M493</accession>
    <name>B8M493_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_024190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
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        <property type="protein sequence ID" value="EED19088.1"/>
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    <dbReference type="PhylomeDB" id="B8M493"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
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    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="659"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="665"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="684"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED19088.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="738" mass="83206" checksum="FDB72F0E87B72724" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4M8</accession>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
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        <property type="protein sequence ID" value="EED19223.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:2-methylcitrate dehydratase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="90"/>
            <end position="346"/>
        </location>
    </feature>
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        <location>
            <begin position="363"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED19223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="571" mass="63284" checksum="53251894806FB618" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4T5</accession>
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        <submittedName>
            <fullName evidence="8">C6 transcription factor, putative</fullName>
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    </protein>
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        <name evidence="8" type="ORF">TSTA_026760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED19370.1"/>
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    <dbReference type="PhylomeDB" id="B8M4T5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="75"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="683"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="701"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED19370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="840" mass="93211" checksum="DDDB1C6CAF4873C7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4Y0</accession>
    <name>B8M4Y0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_027140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479849.1">
        <property type="nucleotide sequence ID" value="XM_002479804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4Y0"/>
    <dbReference type="FunCoup" id="B8M4Y0">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M4Y0"/>
    <dbReference type="GeneID" id="8109633"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_027140"/>
    <dbReference type="eggNOG" id="ENOG502QRAT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003938_0_0_1"/>
    <dbReference type="InParanoid" id="B8M4Y0"/>
    <dbReference type="OMA" id="DRWVMSI"/>
    <dbReference type="OrthoDB" id="5579281at2759"/>
    <dbReference type="PhylomeDB" id="B8M4Y0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902657">
        <property type="term" value="P:protein localization to prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040345">
        <property type="entry name" value="Mug56/Spo71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039486">
        <property type="entry name" value="Mug56/Spo71_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057379">
        <property type="entry name" value="PH_SPO71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029217">
        <property type="entry name" value="Spo7_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28076:SF1">
        <property type="entry name" value="PROSPORE MEMBRANE ADAPTER PROTEIN SPO71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28076">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15404">
        <property type="entry name" value="PH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23207">
        <property type="entry name" value="PH_SPO71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15407">
        <property type="entry name" value="Spo7_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01316">
        <property type="entry name" value="Spo7_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="579"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="831"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1014" mass="116997" checksum="90900C398715984A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8M563</accession>
    <name>B8M563_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Indoleamine 2,3-dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_029450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Produces N-formyl-kynurenine through the oxidation of tryptophan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.52" evidence="5"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480103.1">
        <property type="nucleotide sequence ID" value="XM_002480058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M563"/>
    <dbReference type="FunCoup" id="B8M563">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M563"/>
    <dbReference type="GeneID" id="8106512"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_029450"/>
    <dbReference type="eggNOG" id="ENOG502QV6W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010089_0_0_1"/>
    <dbReference type="InParanoid" id="B8M563"/>
    <dbReference type="OMA" id="HVLAWIM"/>
    <dbReference type="OrthoDB" id="540174at2759"/>
    <dbReference type="PhylomeDB" id="B8M563"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.480:FF:000004">
        <property type="entry name" value="Indoleamine 2,3-dioxygenase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF5">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00876">
        <property type="entry name" value="IDO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="388"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED19669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="494" mass="54736" checksum="E3AE935D169F7B65" modified="2009-03-03" version="1">MLAPIPVLSDYDIDPQRGFLPPELPLTSLPDPYYAKWETVIDKVQALILSGRIRSTVQRLPVLSTAYLHTEAEWQRAYVVLTFMLHAYVWGGDVPEEIIPPPISVPLLEVCEHLDLPPVATYAAVCLWNYKPIFPDEPADDLENLSVINTLTGSTDEQWFYLVSVAIEARGAPMLPLMLEAIAAARREDSAVVTSCLQELAQCITEISVIMQRLFEHCDPHVFYHKVRPFLAGSKNMGDAGLPRGVMFDTDTGTTEYRQYGGGSNAQSSLVQFFDIVLGIEHRPTGIGRDGGGAQSDSEGLSPKPRHNFIQEMRQYMPPAHRKFLEHIGSVANIREYVDAHRSDKALCLAYDASLAMLRDLRDKHIQVVSRYIIVKSREQRRNSLSNPRPPTQLAPPPPPTTTRINLANVKSGNNKKLRGTGGTALIPFLKQARDETGEPAIDAWARRLLSNGPADRSFATLGKVGEHADGQIEIVGMAGTWAMDESEGGICHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5G8</accession>
    <name>B8M5G8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_030410</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480208.1">
        <property type="nucleotide sequence ID" value="XM_002480163.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B8M5G8">
        <property type="interactions" value="1042"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M5G8"/>
    <dbReference type="GeneID" id="8101720"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_030410"/>
    <dbReference type="eggNOG" id="KOG1195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006406_6_2_1"/>
    <dbReference type="InParanoid" id="B8M5G8"/>
    <dbReference type="OMA" id="YEFKWER"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="PhylomeDB" id="B8M5G8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07956">
        <property type="entry name" value="Anticodon_Ia_Arg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.70:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 10 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginyl tRNA synthetase N-terminal" evidence="13">
        <location>
            <begin position="42"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="DALR anticodon binding" evidence="12">
        <location>
            <begin position="504"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="257"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED19774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="641" mass="71841" checksum="A8F912A396EC3CE8" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8M643</accession>
    <name>B8M643_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_023770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479477.1">
        <property type="nucleotide sequence ID" value="XM_002479432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M643"/>
    <dbReference type="FunCoup" id="B8M643">
        <property type="interactions" value="1478"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M643"/>
    <dbReference type="GeneID" id="8109559"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_023770"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_5_11_1"/>
    <dbReference type="InParanoid" id="B8M643"/>
    <dbReference type="OMA" id="PAKMNRD"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="PhylomeDB" id="B8M643"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="559" mass="63864" checksum="AD9E8A65DE5153AF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6I2</accession>
    <name>B8M6I2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LEA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_027400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479878.1">
        <property type="nucleotide sequence ID" value="XM_002479833.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479879.1">
        <property type="nucleotide sequence ID" value="XM_002479834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6I2"/>
    <dbReference type="STRING" id="441959.B8M6I2"/>
    <dbReference type="GeneID" id="8109659"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_027400"/>
    <dbReference type="eggNOG" id="ENOG502SBN9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128874_1_2_1"/>
    <dbReference type="InParanoid" id="B8M6I2"/>
    <dbReference type="OMA" id="APCNKGP"/>
    <dbReference type="OrthoDB" id="4023585at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="112" mass="11925" checksum="0CA70DFCD7AC7FFA" modified="2009-03-03" version="1">MSFLTRVAPTRFAVTSTSFQAYRSFSTTLATQRGPVEATKDVLKKADRTVSDAAVKGIETGETLTHKAQETLGVKSKEAEGKAKEVAGEAKGKAHELEGKAKGKAEELRSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6N7</accession>
    <name>B8M6N7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_027900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479933.1">
        <property type="nucleotide sequence ID" value="XM_002479888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6N7"/>
    <dbReference type="STRING" id="441959.B8M6N7"/>
    <dbReference type="GeneID" id="8108306"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_027900"/>
    <dbReference type="HOGENOM" id="CLU_1171288_0_0_1"/>
    <dbReference type="InParanoid" id="B8M6N7"/>
    <dbReference type="OrthoDB" id="3562449at2759"/>
    <dbReference type="PhylomeDB" id="B8M6N7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="142"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="237" mass="26515" checksum="B04498994539258B" modified="2009-03-03" version="1">MEQMPNTEESSSQHFSSSSAPESAEEQAVVQPSHASQKSESQRLPSTSPKSTEEQGAAQPPRASQIPEAQQSTSSFPPKSTEEQNVAQPQAPQIPEGQKSAEGQPIVQPTPSQIPETRGNQFVPIQVGKLPSTLPDTIDGSDPYQIFYLIFSDAFFQNVAFNTNLHAANARRENPSDGMRPWHDTTREEVKVYFGIMVYMNCHGAPNHETYWNRDQNIGPIHLVPTYMQLYRFQQMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6P4</accession>
    <name>B8M6P4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_027970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the lipid remodeling steps of GPI-anchor maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PGAP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479940.1">
        <property type="nucleotide sequence ID" value="XM_002479895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6P4"/>
    <dbReference type="FunCoup" id="B8M6P4">
        <property type="interactions" value="182"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M6P4"/>
    <dbReference type="GeneID" id="8108313"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_027970"/>
    <dbReference type="eggNOG" id="KOG2970">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032917_1_1_1"/>
    <dbReference type="InParanoid" id="B8M6P4"/>
    <dbReference type="OMA" id="DFMIEDC"/>
    <dbReference type="OrthoDB" id="419770at2759"/>
    <dbReference type="PhylomeDB" id="B8M6P4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016482533" description="Post-GPI attachment to proteins factor 3" evidence="7">
        <location>
            <begin position="30"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED19506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="334" mass="39437" checksum="81F3B2AE1280C84E" modified="2009-03-03" version="1">MQVFRSLSYASRVSICIFILVLFVGQSAASLGDRLPDFKECVKICKEENCQDGNSALPLYLRLMLWTCDAECDYTCQHVITDRRVNREFPMLQPVVQFHGKWPFYRVLGMQEVFSVLFSFLNFLAHYYGLKWIESSIPASYPLRKYYFGFGYFGYASWTFSMLFHTRDFPLTEKLDYWAAGASILYGLFLAVIRIFRLDQEQPNYKPALRRLWTYLCVGLYIAHVSYLTFWSWDYTYNMIANVVVGVIQNILWTAFSIYRYRKEPKKSWMAWPAMIVLWISLAMSLELFDFPPWWGLVDAHSLWHLGTVIPTAWWYLFIIRDAKNDLATERLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6Y7</accession>
    <name>B8M6Y7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Allantoinase Dal1, putative</fullName>
            <ecNumber evidence="6">3.5.2.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_034460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.5.2.5" evidence="6"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480641.1">
        <property type="nucleotide sequence ID" value="XM_002480596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6Y7"/>
    <dbReference type="FunCoup" id="B8M6Y7">
        <property type="interactions" value="1246"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M6Y7"/>
    <dbReference type="GeneID" id="8104288"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_034460"/>
    <dbReference type="eggNOG" id="KOG2584">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015572_4_0_1"/>
    <dbReference type="InParanoid" id="B8M6Y7"/>
    <dbReference type="OMA" id="SRLHVCH"/>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="PhylomeDB" id="B8M6Y7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009442">
        <property type="term" value="P:allantoin assimilation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF2">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="5">
        <location>
            <begin position="57"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED20207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="533" mass="57271" checksum="D121786588A62810" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2024-01-24" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B8M725</accession>
    <name>B8M725_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA2/NAM7 helicase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_034800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480679.1">
        <property type="nucleotide sequence ID" value="XM_002480634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M725"/>
    <dbReference type="GeneID" id="8104322"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_034800"/>
    <dbReference type="HOGENOM" id="CLU_1929008_0_0_1"/>
    <dbReference type="InParanoid" id="B8M725"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="1">
        <location>
            <begin position="65"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="131" mass="14555" checksum="64418799E13A6014" modified="2009-03-03" version="1">MDDLKLYTVHTSIVLSDSEQKKMSQGLLLSLQKDDNQRLENIPTTKAGNHQLSFDMKVANNQAETGLQSHELPQVTTVDAIQEHESNIIICDWINIIAGAGMGFGGDNRRAIVALTRDRADSHSQQGRKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7C4</accession>
    <name>B8M7C4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_035700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480778.1">
        <property type="nucleotide sequence ID" value="XM_002480733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7C4"/>
    <dbReference type="GeneID" id="8107520"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_035700"/>
    <dbReference type="HOGENOM" id="CLU_2559862_0_0_1"/>
    <dbReference type="InParanoid" id="B8M7C4"/>
    <dbReference type="OrthoDB" id="4507940at2759"/>
    <dbReference type="PhylomeDB" id="B8M7C4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="17"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED20344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="82" mass="9088" checksum="2639D08C2815EBBA" modified="2009-03-03" version="1">MLDESETQPNAATDEMTQYLDSDTIHIAPLAFWKEHQTRFPAIAALARDILSFPATGAGVIIIIIINQVYCLYPALLAMTDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7T7</accession>
    <name>B8M7T7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_030790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480250.1">
        <property type="nucleotide sequence ID" value="XM_002480205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7T7"/>
    <dbReference type="STRING" id="441959.B8M7T7"/>
    <dbReference type="GeneID" id="8101758"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_030790"/>
    <dbReference type="eggNOG" id="ENOG502SG6V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025630_2_0_1"/>
    <dbReference type="InParanoid" id="B8M7T7"/>
    <dbReference type="OMA" id="WAVNIRT"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="PhylomeDB" id="B8M7T7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46023:SF6">
        <property type="entry name" value="LIPASE CLASS 3 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46023">
        <property type="entry name" value="LIPASE CLASS 3 PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="2">
        <location>
            <begin position="317"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="484"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="606" mass="66168" checksum="4D28CD13F90A815B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8M800</accession>
    <name>B8M800_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynactin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_032200</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres. Interacts with N4BP2L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Stress fiber</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the dynactin subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19962.1"/>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="657" mass="72368" checksum="7452547467D2DA0E" modified="2009-03-03" version="1"> </sequence>
</entry>
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    <accession>B8M8I1</accession>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
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            <dbReference type="EMBL" id="EED20494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="148" mass="17180" checksum="B4AB56D7ADA299DA" modified="2009-03-03" version="1">MTMAVSSQERYDKLYTAYYNFLVKQLGYRLIRISDLGNTDVVNILSLPQHPTWSRVELNDGSWEYGMPISHINDFQKLVQNVSKAKIDLEYNPLSLLEGDIDFHAAHGLNGIWLEARATRVYGIPRCFYMLLIYIQRMIAKELGRHLV</sequence>
</entry>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Thiaminase-2/PQQC" evidence="1">
        <location>
            <begin position="302"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED20560.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="513" mass="55914" checksum="89E0D252920304A4" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8R2</accession>
    <name>B8M8R2_TALSN</name>
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        <submittedName>
            <fullName evidence="2">DNA repair protein rad9, putative</fullName>
        </submittedName>
    </protein>
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        <dbReference type="NCBI Taxonomy" id="441959"/>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    <dbReference type="GeneID" id="8102165"/>
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    <dbReference type="eggNOG" id="KOG2810">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030657_1_0_1"/>
    <dbReference type="InParanoid" id="B8M8R2"/>
    <dbReference type="OMA" id="NETQCRF"/>
    <dbReference type="OrthoDB" id="60092at2759"/>
    <dbReference type="PhylomeDB" id="B8M8R2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:cellular response to ionizing radiation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007268">
        <property type="entry name" value="Rad9/Ddc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04139">
        <property type="entry name" value="Rad9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="456" mass="50306" checksum="A240ADB098D20DA7" modified="2009-03-03" version="1">MPTLSFSLKPPALLELHDALVCLSKFNESVSIEAEYDSLRLSTLNAAKTAYASFTLDSGKFFSEYTFSTRGVQQSSGQRYGDKFACQMYLKALLSIFKGRAGESRDKQTAVERCNVELHDSPDEAECRLHIQMICGQGVIKSYKLTYESVSVQHALFDQSRVQNQWKVQAKILREIIDHFSPSAEQLDIYPDTGKAIFTSFTNKISDGKEILKQPVHTSVAIDTKDFEEFIVKDGLHVAINVKDFKAAVIHADTMKTSITARYTRPCRPLQLAYTSEDGIESEFTLMTRGDVDEADNDDDASTAASQLSARLAATRVAVQSEPPNSHPAATASASLSAARTTIPPSSRPVIPSRKPELMSSAASRAALADIHDSLFVPADDDRQWDEQVDDEANDQDILGWDSNIEPGAYHEGRPRPLTDDYPTLSSDRQQNNGDVGTAIPPTQPMSQIRNLGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8V3</accession>
    <name>B8M8V3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_038270</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481050.1">
        <property type="nucleotide sequence ID" value="XM_002481005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8V3"/>
    <dbReference type="FunCoup" id="B8M8V3">
        <property type="interactions" value="1023"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M8V3"/>
    <dbReference type="GeneID" id="8102202"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_038270"/>
    <dbReference type="eggNOG" id="KOG0933">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001042_9_0_1"/>
    <dbReference type="InParanoid" id="B8M8V3"/>
    <dbReference type="OMA" id="THNKIAM"/>
    <dbReference type="OrthoDB" id="10255539at2759"/>
    <dbReference type="PhylomeDB" id="B8M8V3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03273">
        <property type="entry name" value="ABC_SMC2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000278">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000385">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Structural maintenance of chromosomes protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027120">
        <property type="entry name" value="Smc2_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="13">
        <location>
            <begin position="522"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="247"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="684"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="836"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED20616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1180" mass="133004" checksum="4CBBBA9B48FC7B46" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8X5</accession>
    <name>B8M8X5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pol II transcription elongation factor subunit Cdc73, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_038440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC73 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481072.1">
        <property type="nucleotide sequence ID" value="XM_002481027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8X5"/>
    <dbReference type="FunCoup" id="B8M8X5">
        <property type="interactions" value="231"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M8X5"/>
    <dbReference type="GeneID" id="8107886"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_038440"/>
    <dbReference type="eggNOG" id="KOG3786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025849_2_0_1"/>
    <dbReference type="InParanoid" id="B8M8X5"/>
    <dbReference type="OMA" id="FRPDYWN"/>
    <dbReference type="OrthoDB" id="2186602at2759"/>
    <dbReference type="PhylomeDB" id="B8M8X5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11990:FF:000003">
        <property type="entry name" value="Pol II transcription elongation factor subunit Cdc73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11990">
        <property type="entry name" value="RNA polymerase II accessory factor, Cdc73 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007852">
        <property type="entry name" value="Cdc73/Parafibromin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031336">
        <property type="entry name" value="CDC73_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038103">
        <property type="entry name" value="CDC73_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466">
        <property type="entry name" value="CDC73 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466:SF8">
        <property type="entry name" value="PARAFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05179">
        <property type="entry name" value="CDC73_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Cell division control protein 73 C-terminal" evidence="6">
        <location>
            <begin position="283"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="235"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED20638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="474" mass="51039" checksum="618A74C2ABB54514" modified="2009-03-03" version="1">MATDPLLSDPLLSLRRAIAAQALPTPTTSSDVSNAADNLTDDLAKANHLYFTHPVPYTLPLNTLTRFVSTANNDTRVDLRSIFFAWQKKDVAIPEYIASAQEVNEALKQKKEKEGGQEEQVLNLVFVERLDLITWLEGASDDSEYIRPLEGAAAAAAAAADVTAPAVAADAVTAAAPKTTVPAAAGPGARPTKVIDPQLQEIYNGERKLGDRNTVLRGIKPTDFSHIRKTAEIFLGRNRGSRGQYPPGSNKGPSGKGGIVVPAPSAGLALPKKPGPSSGSSRRPDPIILLSPSASSPIRLSNIKTFLQDGVFVPPNHPTLASHTTSNMQIITRQTRIGIASGSQGGSGGAGGAAQTSKRPTRFILADSTANFKPDYWQRLVAVFTTGQAWQFKTYKWSNPPELFRHAAGIYVGMAGEHVPNQIKDWGRGVSTFTLARWDDKKGVDGAGRWLDREIVEHIWDVIENNMKAKGWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8M959</accession>
    <name>B8M959_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Yapsin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_111900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481346.1">
        <property type="nucleotide sequence ID" value="XM_002481301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M959"/>
    <dbReference type="SMR" id="B8M959"/>
    <dbReference type="FunCoup" id="B8M959">
        <property type="interactions" value="365"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M959"/>
    <dbReference type="MEROPS" id="A01.015"/>
    <dbReference type="GeneID" id="8098845"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_111900"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_9_3_1"/>
    <dbReference type="InParanoid" id="B8M959"/>
    <dbReference type="OMA" id="TNEPIFP"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="PhylomeDB" id="B8M959"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002874854" evidence="9">
        <location>
            <begin position="21"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="10">
        <location>
            <begin position="65"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED17354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="477" mass="49422" checksum="9133351ECB33B675" modified="2009-03-03" version="1">MRVTVSLPFIVLTTVSVGNALSLYRRDAPAVLEAPIIRRQSAGTLDKRSTSPLDVSIMNMQNSSYWFNLTLGTPPQNFTLSLDTGSSDLWVVAAPGSGKQGGVYDSSSSSSFKSLGLGYNATYAYGTTALGTYATDTLGLGDATVKDFQFVVVNETSSDVGIAGVGYNISTYAAGQNKTYNNLPYALTANGITKSTAYSLWMDGTDADTGILLFGGVNKAKYIGELQTLPVVPVYNNYYSLALALTEVIVQTGDKSTSSTTNLPLAVSLDTGSPFILLPDALVSEIYKSLNATFSDKDGVAYVNCDLMTTNYNVTFSLSGAKINVGLSQLVLYEAFSDWPKNSCLLGIAPGKAGVNLLGDTFLRSAYVVYDLENNEISLANTNFNPGKDDILEIGTGANAVPGATIVPSAVSTATGNGVETATTGVVSATGVTTTASASSGGSSKSTSTSSGIAALATGNAKHFLSGLAGAGLFLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9Y7</accession>
    <name>B8M9Y7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF659 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_119030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482131.1">
        <property type="nucleotide sequence ID" value="XM_002482086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9Y7"/>
    <dbReference type="STRING" id="441959.B8M9Y7"/>
    <dbReference type="GeneID" id="8104353"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119030"/>
    <dbReference type="HOGENOM" id="CLU_2905703_0_0_1"/>
    <dbReference type="InParanoid" id="B8M9Y7"/>
    <dbReference type="OrthoDB" id="2976890at2759"/>
    <dbReference type="PhylomeDB" id="B8M9Y7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED18139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="62" mass="7264" checksum="3872FB7E09DF6FD9" modified="2009-03-03" version="1">MAEILQTILEELNIEHKVFTIIADNAANNETLMSELYYNLKEKLDTKEKFQDFKDWIAICAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9Z2</accession>
    <name>B8M9Z2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="17">ABC metal ion transporter, putative</fullName>
            <ecNumber evidence="17">1.3.1.74</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSTA_119080</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.74" evidence="17"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482136.1">
        <property type="nucleotide sequence ID" value="XM_002482091.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B8M9Z2">
        <property type="interactions" value="293"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M9Z2"/>
    <dbReference type="GeneID" id="8104358"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119080"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_3_1"/>
    <dbReference type="InParanoid" id="B8M9Z2"/>
    <dbReference type="OMA" id="CFETGMR"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="PhylomeDB" id="B8M9Z2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032440">
        <property type="term" value="F:2-alkenal reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042592">
        <property type="term" value="P:homeostatic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000020">
        <property type="entry name" value="ABC metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000450">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000001">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
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            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="449"/>
            <end position="470"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="531"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="575"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="965"/>
            <end position="989"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1009"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1097"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1199"/>
            <end position="1222"/>
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    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="307"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="627"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="969"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="1290"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="854"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="915"/>
            <end position="943"/>
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    </feature>
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        <location>
            <begin position="926"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EED18144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1541" mass="171766" checksum="068601AD45036EF6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8MA43</accession>
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        </submittedName>
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        <name evidence="7" type="ORF">TSTA_121160</name>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
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    </reference>
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        <text evidence="1">Belongs to the UFD1 family.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:ERAD pathway"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="6.10.130.10">
        <property type="entry name" value="Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AZUL_sf"/>
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        <property type="entry name" value="DUF7590"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
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        <property type="entry name" value="Ufd1-like_Nn"/>
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        <property type="entry name" value="UFD1_N1"/>
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        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
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        <property type="entry name" value="FUSION DEGRADATION PROTEIN (UFD1), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF24503">
        <property type="entry name" value="DUF7590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
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    </dbReference>
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        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23580">
        <property type="entry name" value="Znf_XAF1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
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    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="6">
        <location>
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            <end position="760"/>
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    </feature>
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        <location>
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        <location>
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    </feature>
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        <location>
            <begin position="769"/>
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        </location>
    </feature>
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        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="784"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED18372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1257" mass="140619" checksum="7671BBFD20736EB7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8MA45</accession>
    <name>B8MA45_TALSN</name>
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        <submittedName>
            <fullName evidence="12">Calcium permease family membrane transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_121180</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002482321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MA45"/>
    <dbReference type="FunCoup" id="B8MA45">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MA45"/>
    <dbReference type="GeneID" id="8099358"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_121180"/>
    <dbReference type="eggNOG" id="KOG1397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001583_0_0_1"/>
    <dbReference type="InParanoid" id="B8MA45"/>
    <dbReference type="OMA" id="PQWDMIT"/>
    <dbReference type="OrthoDB" id="16982at2759"/>
    <dbReference type="PhylomeDB" id="B8MA45"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990816">
        <property type="term" value="C:vacuole-mitochondrion membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
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</entry>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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        <source>
            <dbReference type="EMBL" id="EED18627.1"/>
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        <source>
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</entry>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="598" mass="64581" checksum="5E7504F1BEA061F2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBG1</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481817.1">
        <property type="nucleotide sequence ID" value="XM_002481772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBG1"/>
    <dbReference type="GeneID" id="8099642"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_116150"/>
    <dbReference type="HOGENOM" id="CLU_2307943_0_0_1"/>
    <dbReference type="InParanoid" id="B8MBG1"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="PhylomeDB" id="B8MBG1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED17825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="100" mass="11118" checksum="E380332433894701" modified="2009-03-03" version="1">MELYINTQDEFLGNALQAASIGEGTKVVQMLSEKVADLNAQDRQAEVNAQDGHYGNALQVASARANEKTQRTLFDEEANVDILYDYPCKEQYASFPEEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBZ7</accession>
    <name>B8MBZ7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">prephenate dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_121810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>prephenate + H(+) = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="2"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482435.1">
        <property type="nucleotide sequence ID" value="XM_002482390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBZ7"/>
    <dbReference type="FunCoup" id="B8MBZ7">
        <property type="interactions" value="126"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MBZ7"/>
    <dbReference type="GeneID" id="8098170"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_121810"/>
    <dbReference type="eggNOG" id="KOG2797">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035008_5_1_1"/>
    <dbReference type="InParanoid" id="B8MBZ7"/>
    <dbReference type="OMA" id="PLMIYRE"/>
    <dbReference type="OrthoDB" id="983542at2759"/>
    <dbReference type="PhylomeDB" id="B8MBZ7"/>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04905">
        <property type="entry name" value="ACT_CM-PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13532">
        <property type="entry name" value="PBP2_PDT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000034">
        <property type="entry name" value="Chorismate mutase/prephenate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008865">
        <property type="entry name" value="PRK11898.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022">
        <property type="entry name" value="PREPHENATE DEHYDRATASE P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022:SF19">
        <property type="entry name" value="PREPHENATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="8">
        <location>
            <begin position="6"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="228"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED18443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="315" mass="34740" checksum="5630C7671F75FFE3" modified="2009-03-03" version="1">MKDSIRVTFLGPAASFSHQAAIDSFGKDDSVSLFPSVSFAEAFSAIQNNDADYAVIPIENSTNGSVVQTLDLLADRQGSNEDVIVCADYFLTVQHCLIVGARPVNKHKEDSFNSINKLYTHPQAWGQCEKFLSQHFRGIERQDVSSTSKAVEIVAKETSGREAAIASKLAAEHHGAFVLQEHIEDRADNTTRFLVLRNRLSKQSSNITSFLKTGSDTDEPKKKRKSLISFMIEHSAPGALADALAVFKKHGLNLTSINSRPSLIRPWQYIFFVECEHVPTANDETCISDILKELGTICHACRSIGSWIDGRDLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCC5</accession>
    <name>B8MCC5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7580 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_123000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482563.1">
        <property type="nucleotide sequence ID" value="XM_002482518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCC5"/>
    <dbReference type="STRING" id="441959.B8MCC5"/>
    <dbReference type="GeneID" id="8102460"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_123000"/>
    <dbReference type="eggNOG" id="ENOG502SNN1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026305_1_0_1"/>
    <dbReference type="InParanoid" id="B8MCC5"/>
    <dbReference type="OMA" id="RVYWESG"/>
    <dbReference type="OrthoDB" id="3565018at2759"/>
    <dbReference type="PhylomeDB" id="B8MCC5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002874962" description="DUF7580 domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7580" evidence="2">
        <location>
            <begin position="195"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED18571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="582" mass="66149" checksum="CEC0FB5660412C64" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDB6</accession>
    <name>B8MDB6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_114520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481633.1">
        <property type="nucleotide sequence ID" value="XM_002481588.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481634.1">
        <property type="nucleotide sequence ID" value="XM_002481589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MDB6"/>
    <dbReference type="GeneID" id="8109214"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_114520"/>
    <dbReference type="eggNOG" id="ENOG502SG78">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110315_2_0_1"/>
    <dbReference type="InParanoid" id="B8MDB6"/>
    <dbReference type="OMA" id="YWKASTW"/>
    <dbReference type="OrthoDB" id="5285218at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="73" mass="8486" checksum="AB14864DF151D49B" modified="2009-03-03" version="1">MGFIEKLQSKLELYRLEQRYTRRKNRSTFYGDAQYVDGEYVYTNGLTSPAVSKNSTGGHWRPTWGRSTSSDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDK0</accession>
    <name>B8MDK0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane ATPase</fullName>
            <ecNumber evidence="10">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_117450</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="10"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481955.1">
        <property type="nucleotide sequence ID" value="XM_002481910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MDK0"/>
    <dbReference type="STRING" id="441959.B8MDK0"/>
    <dbReference type="GeneID" id="8105803"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_117450"/>
    <dbReference type="eggNOG" id="KOG0205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_6_0_1"/>
    <dbReference type="InParanoid" id="B8MDK0"/>
    <dbReference type="OMA" id="GHFELVM"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="PhylomeDB" id="B8MDK0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000008">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="425"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="783"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="810"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="846"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="910"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="961"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="12">
        <location>
            <begin position="89"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="253"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED17963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1036" mass="114543" checksum="01A9A4710C7D998F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDZ4</accession>
    <name>B8MDZ4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">ATP synthase F(0) complex subunit e, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSTA_011800</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 15">Subunit e, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the ATP synthase complex composed at least of ATP5F1A/subunit alpha, ATP5F1B/subunit beta, ATP5MC1/subunit c (homooctomer), MT-ATP6/subunit a, MT-ATP8/subunit 8, ATP5ME/subunit e, ATP5MF/subunit f, ATP5MG/subunit g, ATP5MK/subunit k, ATP5MJ/subunit j, ATP5F1C/subunit gamma, ATP5F1D/subunit delta, ATP5F1E/subunit epsilon, ATP5PF/subunit F6, ATP5PB/subunit b, ATP5PD/subunit d, ATP5PO/subunit OSCP. ATP synthase complex consists of a soluble F(1) head domain (subunits alpha(3) and beta(3)) - the catalytic core - and a membrane F(0) domain - the membrane proton channel (subunits c, a, 8, e, f, g, k and j). These two domains are linked by a central stalk (subunits gamma, delta, and epsilon) rotating inside the F1 region and a stationary peripheral stalk (subunits F6, b, d, and OSCP).</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ATPase e subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483305.1">
        <property type="nucleotide sequence ID" value="XM_002483260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MDZ4"/>
    <dbReference type="FunCoup" id="B8MDZ4">
        <property type="interactions" value="106"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MDZ4"/>
    <dbReference type="GeneID" id="8104028"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_011800"/>
    <dbReference type="eggNOG" id="ENOG502SDS3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159435_2_0_1"/>
    <dbReference type="InParanoid" id="B8MDZ4"/>
    <dbReference type="OMA" id="FYGLYHQ"/>
    <dbReference type="OrthoDB" id="2125027at2759"/>
    <dbReference type="PhylomeDB" id="B8MDZ4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008386">
        <property type="entry name" value="ATP_synth_F0_esu_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12427">
        <property type="entry name" value="ATP SYNTHASE E CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12427:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT E, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05680">
        <property type="entry name" value="ATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11 15" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 15" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 15" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00057306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00074682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EED16071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="90" mass="10170" checksum="BE183BA8B54E9292" modified="2009-03-03" version="1">MASQGVNVLRYSALVGGIFYGLWHQSALNTQAKQAEHDREYKHKESLIQKAKAEWAKKNAPPDTKSGLVTDPEDPRFDLEKFLIAKAEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEK3</accession>
    <name>B8MEK3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_017050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483864.1">
        <property type="nucleotide sequence ID" value="XM_002483819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEK3"/>
    <dbReference type="STRING" id="441959.B8MEK3"/>
    <dbReference type="GeneID" id="8103678"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_017050"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_1_2_1"/>
    <dbReference type="InParanoid" id="B8MEK3"/>
    <dbReference type="OMA" id="SIYGYAC"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="PhylomeDB" id="B8MEK3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF34">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G02770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877464" description="FAD-binding PCMH-type domain-containing protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="82"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED16630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="520" mass="56962" checksum="7EA3A4BBB6AB3176" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MET8</accession>
    <name>B8MET8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_020290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484205.1">
        <property type="nucleotide sequence ID" value="XM_002484160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MET8"/>
    <dbReference type="STRING" id="441959.B8MET8"/>
    <dbReference type="GeneID" id="8108840"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_020290"/>
    <dbReference type="eggNOG" id="KOG1150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070940_1_0_1"/>
    <dbReference type="InParanoid" id="B8MET8"/>
    <dbReference type="OMA" id="EIVNKAW"/>
    <dbReference type="OrthoDB" id="342454at2759"/>
    <dbReference type="PhylomeDB" id="B8MET8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620:SF1">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="35"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED16971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="213" mass="25143" checksum="F6226760F25AD5B3" modified="2009-03-03" version="1">MADDELAALNALEKEASEFNKDAEIDRIRKAFPLDAYAILDLQPGVPDSDIKLQYRKKSLLIHPDKTQNPLAPDAFDRLKKAQTTLLDEKARERLDECIADARRLLIREHKYTLDSPELKTEEFKVEWRKKTVEVLLEDEARRRRQLKAKMQEEGREKQKEEEEMEARKRKREADQAWEATRDERIGSWRDWQKGKQKDKEGGKKKKKMKVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFI2</accession>
    <name>B8MFI2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_017900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483950.1">
        <property type="nucleotide sequence ID" value="XM_002483905.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483951.1">
        <property type="nucleotide sequence ID" value="XM_002483906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFI2"/>
    <dbReference type="GeneID" id="8109047"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_017900"/>
    <dbReference type="eggNOG" id="ENOG502SAXD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1195561_0_0_1"/>
    <dbReference type="InParanoid" id="B8MFI2"/>
    <dbReference type="OrthoDB" id="4227298at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED16716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="232" mass="25720" checksum="1CC5BCFF234BC09D" modified="2009-03-03" version="1">MRSILFQLAVEKKGKMWATALSDIFFLPVLLLVSIPLALSASITTALALITLFIRALVVYFELSIALLANFFLFPAHSPATGSLLALTEGTTPGIERTARTPKYSSHIGAQQTGFTKSRRGSLSSKDGVAEDYFSHHNHSQHGYAPIHSPHEALSSFISNNAERDFEGVGGWRTPLTRRKHHQTSSVPSLSRKNSSEEELLLDNNDDEVWLSINKRLELPSRRSAWKTHSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFQ5</accession>
    <name>B8MFQ5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_021060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484279.1">
        <property type="nucleotide sequence ID" value="XM_002484234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFQ5"/>
    <dbReference type="STRING" id="441959.B8MFQ5"/>
    <dbReference type="GeneID" id="8109363"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_021060"/>
    <dbReference type="eggNOG" id="ENOG502S1W1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006713_0_0_1"/>
    <dbReference type="InParanoid" id="B8MFQ5"/>
    <dbReference type="OMA" id="MERIRYD"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="PhylomeDB" id="B8MFQ5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4470" evidence="2">
        <location>
            <begin position="178"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED17045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="874" mass="98168" checksum="81BA558160EA4D3D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFS9</accession>
    <name>B8MFS9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_009210</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483030.1">
        <property type="nucleotide sequence ID" value="XM_002482985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFS9"/>
    <dbReference type="FunCoup" id="B8MFS9">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MFS9"/>
    <dbReference type="GeneID" id="8100782"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_009210"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_3_1"/>
    <dbReference type="InParanoid" id="B8MFS9"/>
    <dbReference type="OMA" id="TQETHRD"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="PhylomeDB" id="B8MFS9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF38">
        <property type="entry name" value="POLYAMINE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="34"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED15796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="472" mass="51636" checksum="AA86C93945EB21AD" modified="2009-03-03" version="1">MPSEKTLTETVPVTDWDSDSRNPHNWPTWKRAYHSVLPAVFGLVVTVGSSIYTSAVDDVKKAFHISDVAATVPFSLFLLGLGFGPMLAAPLSENFGRTSSYVISLPIYALFTLGAGFSHTFGALVACRFLAGIFASPPLVVGAGTIADIWKPEHRALTTTLFALCPFLGPALGPVMGGFAVAAKGWRWTQWIILFWAVFAYLLVLGMHETYKKIIVARASKKAGGHFTPPGPSGREAIILLFQVTLIRPIKMLYSEPIVIAWSLYIGFTFAVLYSFFAAFPYVYATVYGFDIQQIGLTFIPVAIGTVLGSITFIWIDQTIYQKRNAQWTAQGGTGRLPPEQRLYASMIGGCGLPIGLFWFAWTARPDIHWISPMIATVVIGWGNMCITMSGLLYLLDVYDALTGASAVAAASLLRYVLAAAFPLFVNPMYRNLGVGWATSVFAFISVALTPIPWVFYRWGLRLRSSSKVMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFX4</accession>
    <name>B8MFX4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_009620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483075.1">
        <property type="nucleotide sequence ID" value="XM_002483030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFX4"/>
    <dbReference type="STRING" id="441959.B8MFX4"/>
    <dbReference type="GeneID" id="8102758"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_009620"/>
    <dbReference type="eggNOG" id="ENOG502SVBM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1788108_0_0_1"/>
    <dbReference type="InParanoid" id="B8MFX4"/>
    <dbReference type="OrthoDB" id="4842715at2759"/>
    <dbReference type="PhylomeDB" id="B8MFX4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="145" mass="16064" checksum="0C0D7AC09F30CF64" modified="2009-03-03" version="1">MAWISIHYNVLVRQQFGALLLRSITDLTTCLIHNVEQALNQGMTASLLTLDVKGAFDSVLPGRLIHRLRKQGWPINLVLWIASFATGRSVQIRLDGEISPSTDIACGLPQGSLVSSILFMLYIAPLFRLGNPRNSQPGNLNISYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGD6</accession>
    <name>B8MGD6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_013560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483490.1">
        <property type="nucleotide sequence ID" value="XM_002483445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGD6"/>
    <dbReference type="GeneID" id="8099155"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_013560"/>
    <dbReference type="HOGENOM" id="CLU_877659_0_0_1"/>
    <dbReference type="InParanoid" id="B8MGD6"/>
    <dbReference type="OrthoDB" id="4523365at2759"/>
    <dbReference type="PhylomeDB" id="B8MGD6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="317" mass="35887" checksum="5D08E9F681A187C4" modified="2009-03-03" version="1">MARSYSIIRSKVGTRRVLKEDWPSMVIQIEHLTNELKLALGIQENLPTLLESNEIPRAPHADMMLYSEVMSEKNTQRPVHSGQVVVISYDLKSDWWKNITVWAWNRPPYGRCLDEVFIVITPFHIIFARVPRDTNDAWLAYDYRAIMGVIDKTLQSNVSPVGGKHWSYMYRLIPAFTLNPNDAKKPRPAGPQRRLNSLRELRLNTVYESRFNSYLYYVPPAEWPDRNPNFTIRVGNYGRPGDEDRPHVQVNDMSGEYIITGKNEEGPDVTVNDNGNATENPVVAENPGQNGRENPVGDGVESTPGTPGTTDTAHNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGG7</accession>
    <name>B8MGG7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Isoamyl alcohol oxidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_013860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483521.1">
        <property type="nucleotide sequence ID" value="XM_002483476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGG7"/>
    <dbReference type="STRING" id="441959.B8MGG7"/>
    <dbReference type="GeneID" id="8099185"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_013860"/>
    <dbReference type="eggNOG" id="ENOG502QQWK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_4_2_1"/>
    <dbReference type="InParanoid" id="B8MGG7"/>
    <dbReference type="OMA" id="VNRYQFG"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="PhylomeDB" id="B8MGG7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877492" evidence="3">
        <location>
            <begin position="17"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="115"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED16287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="566" mass="60809" checksum="4E24B5E73566B779" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGX3</accession>
    <name>B8MGX3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Short chain oxidoreductase/dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_014450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483588.1">
        <property type="nucleotide sequence ID" value="XM_002483543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGX3"/>
    <dbReference type="STRING" id="441959.B8MGX3"/>
    <dbReference type="GeneID" id="8107828"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_014450"/>
    <dbReference type="eggNOG" id="KOG1209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="InParanoid" id="B8MGX3"/>
    <dbReference type="OMA" id="KEDHCDV"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="PhylomeDB" id="B8MGX3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877494" evidence="5">
        <location>
            <begin position="21"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED16354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="286" mass="30429" checksum="D1DE50F6327CE604" modified="2009-03-03" version="1">MPILNWLITGASNGLGLALALEVLKAGHKVIATARNVTKASAAHPEIEQLGGSWLQLDVNKSDTKLIVESAVCDLFGGRIDVLANNAGYSILGSIEDLSEKEIEDQFNTNLYGPIRTIKAALPSMRAQRSGVIVNVSSIAALDPRPSGGIYGASKSSLENLSEALCLELAPFNIRVLIVIPGGFRTDFLSGNLEPEAPMTKDYEGTPLHATLNSFRAYNGNQPGDPAKGMRRVVEVVEGTGLGEGKQGLLRLPLGADCLERAYSKVSALQRDLDGFDSIARSTNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8MH79</accession>
    <name>B8MH79_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sugar transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_019550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484127.1">
        <property type="nucleotide sequence ID" value="XM_002484082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MH79"/>
    <dbReference type="GeneID" id="8104650"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_019550"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_921899_0_0_1"/>
    <dbReference type="InParanoid" id="B8MH79"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="PhylomeDB" id="B8MH79"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF59">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED16893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="33642" checksum="60A2D8C4245298E5" modified="2009-03-03" version="1">MLFTFIILKQISPKAIRGLLILQYAACQMVGVAFGLFINYGVAKSYTGTNKHNGCSPPFYNSSQQQSGIRHLPADHPLILSEIKAIEIQILHEVEPDSPTIFGYLGVKGTESTLLAPGIYAIVKFVSTMLFGIFVMDFIGRSRSLMTGICLQIVTLAYYQGTPCASRASTGAIVAIYFQAVAWSIGRFSIPYVLGPEIFPIPIRSLNMSISMAFHWLFYFASSRETSSLLAAMEKWSAFVFYGFICTVFFARLDTTGKSIEALASLFRRPWYTVWRVAYPTANEKQEVTDDPKSNVDHVEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHN9</accession>
    <name>B8MHN9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Origin recognition complex subunit 3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_011290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483254.1">
        <property type="nucleotide sequence ID" value="XM_002483209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHN9"/>
    <dbReference type="FunCoup" id="B8MHN9">
        <property type="interactions" value="750"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MHN9"/>
    <dbReference type="GeneID" id="8109902"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_011290"/>
    <dbReference type="eggNOG" id="KOG2538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015257_1_0_1"/>
    <dbReference type="InParanoid" id="B8MHN9"/>
    <dbReference type="OMA" id="YCLMEHY"/>
    <dbReference type="OrthoDB" id="10265211at2759"/>
    <dbReference type="PhylomeDB" id="B8MHN9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20704">
        <property type="entry name" value="Orc3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020795">
        <property type="entry name" value="ORC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045667">
        <property type="entry name" value="ORC3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040855">
        <property type="entry name" value="ORC_WH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07034">
        <property type="entry name" value="ORC3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18137">
        <property type="entry name" value="WHD_ORC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 N-terminal" evidence="7">
        <location>
            <begin position="37"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 3 winged helix C-terminal" evidence="8">
        <location>
            <begin position="582"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED16020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="696" mass="78151" checksum="ECE371AAB46EB80D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHQ6</accession>
    <name>B8MHQ6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_014780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483620.1">
        <property type="nucleotide sequence ID" value="XM_002483575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHQ6"/>
    <dbReference type="GeneID" id="8107861"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_014780"/>
    <dbReference type="eggNOG" id="ENOG502QRB5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034574_1_0_1"/>
    <dbReference type="InParanoid" id="B8MHQ6"/>
    <dbReference type="OMA" id="MNWAFVI"/>
    <dbReference type="OrthoDB" id="4480814at2759"/>
    <dbReference type="PhylomeDB" id="B8MHQ6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G07470)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="326" mass="34750" checksum="61D4CEA9826E89C4" modified="2009-03-03" version="1">MTSIGRIACIVFPYAVTVGALISLIFVGIGSTNSNSSTKTDLYFFRADLSNLTSAGGSSLANEAASALGDLTNFGSSCFEAALAEALAKNHIRDFYDIGLWGYCAGNKTSSGKFEAEFAFDPVSVWGLNNTGSSKDVEDILPSNLHKALNTYKAVSKWIFIAYIIAFGVTALELIVGLFAICSRLGSLVTSIISGVAFFFTAAASITATAMFAVFTGTFNTALKQYGMHGSMGHNIYVATWIATAFAFCGTLFWLFSSCCCAARSPYHGGRAGRSRVMAEKAPYTYERVSSPYGGAPAGPAAPYSGQHNVPMQTFRQDAYEPFRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHX7</accession>
    <name>B8MHX7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phytase A</fullName>
            <ecNumber evidence="4">3.1.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Histidine acid phosphatase phyA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Myo-inositol hexakisphosphate phosphohydrolase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Myo-inositol-hexaphosphate 3-phosphohydrolase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TSTA_015430</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,5,6-tetrakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77115"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57798"/>
            <dbReference type="ChEBI" id="CHEBI:195535"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:77116"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1D-myo-inositol 1,2,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,6-trisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:195535"/>
            <dbReference type="ChEBI" id="CHEBI:195537"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:77120"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1D-myo-inositol 1,2,6-trisphosphate + H2O = 1D-myo-inositol 1,2-bisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77131"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:195537"/>
            <dbReference type="ChEBI" id="CHEBI:195539"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:77132"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol 1,2-bisphosphate + H2O = 1D-myo-inositol 2-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84142"/>
            <dbReference type="ChEBI" id="CHEBI:195539"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:77136"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16989"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57798"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="EC" id="3.1.3.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:16990"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.8" evidence="4"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483690.1">
        <property type="nucleotide sequence ID" value="XM_002483645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHX7"/>
    <dbReference type="STRING" id="441959.B8MHX7"/>
    <dbReference type="GeneID" id="8106285"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_015430"/>
    <dbReference type="eggNOG" id="KOG1382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8MHX7"/>
    <dbReference type="OMA" id="CRVTFAQ"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="PhylomeDB" id="B8MHX7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF24">
        <property type="entry name" value="3-PHYTASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="20" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="18">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="18">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="119"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="488"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EED16456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="524" mass="58269" checksum="9965BC214D93B1D2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIS6</accession>
    <name>B8MIS6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="3">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_050280</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="3"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485540.1">
        <property type="nucleotide sequence ID" value="XM_002485495.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485541.1">
        <property type="nucleotide sequence ID" value="XM_002485496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIS6"/>
    <dbReference type="FunCoup" id="B8MIS6">
        <property type="interactions" value="393"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MIS6"/>
    <dbReference type="GeneID" id="8109071"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_050280"/>
    <dbReference type="eggNOG" id="KOG1448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_1_1_1"/>
    <dbReference type="InParanoid" id="B8MIS6"/>
    <dbReference type="OMA" id="DVCPQRS"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000014">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000043">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF57">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="134"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="185"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED15587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="364" mass="39735" checksum="534C70317DFF267B" modified="2009-03-03" version="1">MIANLLTIAGVDHVITLDLHASQMQGFFAKPVDNLFAEPLIARWIRMNVPSWRDAVVVSKNAGGTKRVTSLADTLKLNFGIVTTDRRRPKNNVSMSDSMVFFDTIERGNHSRRSMGLLAVDQDSAVDDYFLSRSADTLRPETPPSARRPSELEAAEHTTDERAREVITGRIVQGHLVDEDFVDGSQVATPLPPTGSENGDSVNNDHMTSSFMSVASSHEGHALGGTYDAAESDDDDPAVPAPNHDEKTITLVGDVKDKPVFIIDDMIDRSGSWITAAETVVRGGGAKTVYCIATHGLFGDNCLEEMESSDAIDHIVVTNSFPIPPEKMRLSKKLHVIDVSALLSESIRRHHYGESISALFQLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJ39</accession>
    <name>B8MJ39_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Jerky, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_051370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485654.1">
        <property type="nucleotide sequence ID" value="XM_002485609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJ39"/>
    <dbReference type="GeneID" id="8106339"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_051370"/>
    <dbReference type="eggNOG" id="KOG3105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018294_0_3_1"/>
    <dbReference type="InParanoid" id="B8MJ39"/>
    <dbReference type="OMA" id="QWMQKLD"/>
    <dbReference type="OrthoDB" id="125347at2759"/>
    <dbReference type="PhylomeDB" id="B8MJ39"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041188">
        <property type="entry name" value="HTH_ABP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18107">
        <property type="entry name" value="HTH_ABP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="98"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED15701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="546" mass="64177" checksum="9A3A5437B5F4C0B2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-31" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJJ8</accession>
    <name>RTC5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName>Restriction of telomere capping protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rtc5</name>
        <name type="ORF">TSTA_046520</name>
    </gene>
    <organism>
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RTC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485151.1">
        <property type="nucleotide sequence ID" value="XM_002485106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJJ8"/>
    <dbReference type="SMR" id="B8MJJ8"/>
    <dbReference type="FunCoup" id="B8MJJ8">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MJJ8"/>
    <dbReference type="GeneID" id="8099563"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_046520"/>
    <dbReference type="eggNOG" id="ENOG502QV3R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011918_1_0_1"/>
    <dbReference type="InParanoid" id="B8MJJ8"/>
    <dbReference type="OMA" id="KWEFEAR"/>
    <dbReference type="OrthoDB" id="289228at2759"/>
    <dbReference type="PhylomeDB" id="B8MJJ8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000408846" description="Restriction of telomere capping protein 5">
        <location>
            <begin position="1"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="366"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="155"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="326"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="522"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="544"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="686" mass="75244" checksum="16CFF3B37A15142C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJQ7</accession>
    <name>B8MJQ7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_051930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485709.1">
        <property type="nucleotide sequence ID" value="XM_002485664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJQ7"/>
    <dbReference type="STRING" id="441959.B8MJQ7"/>
    <dbReference type="GeneID" id="8103414"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_051930"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_23_6_1"/>
    <dbReference type="InParanoid" id="B8MJQ7"/>
    <dbReference type="OMA" id="CPDMIIL"/>
    <dbReference type="OrthoDB" id="4226558at2759"/>
    <dbReference type="PhylomeDB" id="B8MJQ7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="72"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="404"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED15756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="733" mass="82894" checksum="5918B1000289D17D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MK28</accession>
    <name>B8MK28_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family acetyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_043200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484798.1">
        <property type="nucleotide sequence ID" value="XM_002484753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MK28"/>
    <dbReference type="STRING" id="441959.B8MK28"/>
    <dbReference type="GeneID" id="8104962"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_043200"/>
    <dbReference type="eggNOG" id="ENOG502RR34">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073919_0_0_1"/>
    <dbReference type="InParanoid" id="B8MK28"/>
    <dbReference type="OMA" id="CMLYCMV"/>
    <dbReference type="OrthoDB" id="512662at2759"/>
    <dbReference type="PhylomeDB" id="B8MK28"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF4">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY FAMILY (AFU_ORTHOLOGUE AFUA_4G09540)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="80"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="237" mass="27375" checksum="3B24D47E2DFE00C8" modified="2009-03-03" version="1">MSIQILPLQQEDIPGVVECIQEGFADDPYFKWVYDGTRFNKERNSSSLTARCLWGINNALFYVAKEVDNNNQPQQGGRNGRILGVSCWLAPQPASQAQSWYSWSQLWLLSFRQLLTNIRFFGRGGLIVKRYWIWKEQQTAAQKEIWTDKERGYYFCNIVTVRPDAQGKGIGRKLFEVVTQRADREGVKCYLESSKSEPNVKIYEKMGFELVKVIDCDDGGDVCRLFCMVREPKVDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8MK67</accession>
    <name>B8MK67_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-polygalacturonase</fullName>
            <ecNumber evidence="3">3.2.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_043550</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15" evidence="3"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484837.1">
        <property type="nucleotide sequence ID" value="XM_002484792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MK67"/>
    <dbReference type="SMR" id="B8MK67"/>
    <dbReference type="FunCoup" id="B8MK67">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MK67"/>
    <dbReference type="GeneID" id="8097863"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_043550"/>
    <dbReference type="eggNOG" id="ENOG502QTAW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040116_0_0_1"/>
    <dbReference type="InParanoid" id="B8MK67"/>
    <dbReference type="OMA" id="GSTIKFM"/>
    <dbReference type="OrthoDB" id="1546079at2759"/>
    <dbReference type="PhylomeDB" id="B8MK67"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000002">
        <property type="entry name" value="Endopolygalacturonase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF1">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002875176" description="endo-polygalacturonase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED14884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="375" mass="37933" checksum="75587562159324A4" modified="2009-03-03" version="1">MRSFIGLAGLACLSSVVLAVPAPAPTAPAKLEDRAASCTFSGSNGAAAASKSKTSCSTIVLSSVAVPSGTTLDLTNLNDGTKVIFEGTTTFGYAEWSGPLVSVSGNDITVEGASGAVLDGDGSRWWDGKGSNGGKTKPKFFYAHNLKSSSISNIKILNSPVQVFSIDGAQTLTLDHITIDNSAGDSQGGHNTDAFDVGDSNGVTISNAIVQNQDDCLAVNSGTNIIFTGGTCSGGHGLSIGSVGGRSDNTVQTVHIENSTIKNSQNGVRIKTVYGATGSVSGVTYKDITLSGITKYGIVIEQDYENGSPTGTPTNGVPITGLTIDGVTGSVTSSATEVYILCGSGSCSNWTWQGVNITGGKKSSSCKNVPSGASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKG8</accession>
    <name>B8MKG8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_047690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485276.1">
        <property type="nucleotide sequence ID" value="XM_002485231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKG8"/>
    <dbReference type="GeneID" id="8099319"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_047690"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="InParanoid" id="B8MKG8"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="PhylomeDB" id="B8MKG8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED15323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="425" mass="46152" checksum="0705C44FCE99F0C0" modified="2009-03-03" version="1">MTATRTDTKRQPIEPNAAPENFPHEIPGFKWLLVIAAIYSSQFLFALDNITVAKLSWISVSFLIGSAGTDLIWGKFYAQLNAKWTYIVCVAVFEVGSAVCGAALSINAFIIARAICGVSGAGMYIELMTLLSITITIQERPDWMALVVLYQSPYWHRVPPIYLFMFPSDKDPHPGVSFLDRAREIVGLFICSGVLFILLGIQQTYTIFTAVACRIIPIEFFTMPTILILFAATAAGGTTIFVPVYMAPLFFQFTRDDSALESGVRILPFIFVMIVAIIANGAILSKFDLSMSWYLAGGILIVIGAALMYTIYLSTSVSQIYGYTVLIGFGVGHVFSGILLSRPSSAVGFISCAQITGITLSLAIANAVFLDKSREGIKTILPDILASEIEQTIAGARSTLLKSLSPSVKDKVLAIIVDVDAQNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8ML34</accession>
    <name>B8ML34_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Carnitine O-acetyltransferase, mitochondrial</fullName>
            <ecNumber evidence="16">2.3.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TSTA_048900</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-carnitine + acetyl-CoA = O-acetyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:21136"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57589"/>
            <dbReference type="EC" id="2.3.1.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.7" evidence="16"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485403.1">
        <property type="nucleotide sequence ID" value="XM_002485358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ML34"/>
    <dbReference type="FunCoup" id="B8ML34">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8ML34"/>
    <dbReference type="GeneID" id="8100606"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_048900"/>
    <dbReference type="eggNOG" id="KOG3717">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013513_5_1_1"/>
    <dbReference type="InParanoid" id="B8ML34"/>
    <dbReference type="OMA" id="KMDGTPT"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="PhylomeDB" id="B8ML34"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000007">
        <property type="entry name" value="Carnitine O-acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF103">
        <property type="entry name" value="CARNITINE O-ACETYL-TRANSFERASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 19 21" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="20">
        <location>
            <begin position="65"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EED15450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="644" mass="73620" checksum="5392043EB21C3ADE" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMC1</accession>
    <name>B8MMC1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bulb-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_099270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485913.1">
        <property type="nucleotide sequence ID" value="XM_002485868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMC1"/>
    <dbReference type="STRING" id="441959.B8MMC1"/>
    <dbReference type="GeneID" id="8104005"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_099270"/>
    <dbReference type="eggNOG" id="ENOG502RXM4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041043_0_0_1"/>
    <dbReference type="InParanoid" id="B8MMC1"/>
    <dbReference type="OMA" id="VWASGHT"/>
    <dbReference type="OrthoDB" id="2587928at2759"/>
    <dbReference type="PhylomeDB" id="B8MMC1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="entry name" value="Bulb-type lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022441">
        <property type="entry name" value="Para_beta_helix_rpt-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03804">
        <property type="entry name" value="para_beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="alpha-D-mannose-specific plant lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002875216" description="Bulb-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="2">
        <location>
            <begin position="386"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED13675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="507" mass="52423" checksum="AF8C1B4828C63EDB" modified="2009-03-03" version="1">MASRFQGLAILPLLGFAAASCISSGDQNTINNLFKSGGAGTVVQICAGTTISVTGTITFTADNQEISTSGYPTDETRAIIQPASGSDVSMLLSGYGYNGLRVKNIQFDGLRPSLGLVKDGGATIELGQNSNGIEISNIVSKNARAWSCLHLLQGGTDTPCTNVTISNNQIGPCGNEGLNSAGVSQWADGISFACRDSLIENNYVTGSTDGGIVLFGAPGTTVQGNTIVSSTTDAGFGAINMVDYLYDGSYANVLVTNNTITGEKLFNVGIAIGAYAWSFNDDASLQGPATITNNVFSGNIPFAIGVNGWTGGLTVTGNDVSNVNSPTSGYSDANSCVAPTRDLWKQSAHLAYYPTGLTGTNNLQSGFVAADGNSTNFICTAPSLPSSISYGLNELNVGVNTVLANLHNSIVTQYQGDGNIVTYNTSTGSYVPVWASGHTSSVCSSDPSACSCDFQGDGNFVTYASGKPQFVTGTQGKGQKLTFLNQSPWIEITDSAGNVVWDTTDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMU3</accession>
    <name>B8MMU3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_100900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486087.1">
        <property type="nucleotide sequence ID" value="XM_002486042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMU3"/>
    <dbReference type="STRING" id="441959.B8MMU3"/>
    <dbReference type="GeneID" id="8098602"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_100900"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063727_0_0_1"/>
    <dbReference type="InParanoid" id="B8MMU3"/>
    <dbReference type="OMA" id="HAKCAPA"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="PhylomeDB" id="B8MMU3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="41"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="191"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="247"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED13849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="358" mass="38823" checksum="784875ACA8E1D5E9" modified="2009-03-03" version="1">MIEIEVPARLRRAILQNDVLLVKRIIKNNPTYLENPDFEDRSNTSLHLAAIKGHLEIVKLLLSLGHDSCTPNIDRTGYDSAPGISLNIDGSTALHLAAANSHPDCVDLLCRTFPHTVDWKDNEGRTPLMLAAQNSNPSHAPVTANSSSHIPPPTGRRPRAVSTNSSIASEDIATITILLSYNASVTATDIAGNTALHYASAWGNLKAVRALLAAGTPPLSPNKANFTPIDYSVTKQAAQYFQSLANELETSDQQQQQQPLKLNTAATRPIATPPDESRAGGTRMLGSPMSSPVKSRDVEQRQMQHQRQSSNTSPVRKNFGGLRLVIDTESAEYADMDDVPSTAKRIERPSIEESRAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MN00</accession>
    <name>B8MN00_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_101850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486187.1">
        <property type="nucleotide sequence ID" value="XM_002486142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MN00"/>
    <dbReference type="STRING" id="441959.B8MN00"/>
    <dbReference type="GeneID" id="8099230"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_101850"/>
    <dbReference type="eggNOG" id="ENOG502SKQF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1138649_0_0_1"/>
    <dbReference type="InParanoid" id="B8MN00"/>
    <dbReference type="OrthoDB" id="4485682at2759"/>
    <dbReference type="PhylomeDB" id="B8MN00"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF4">
        <property type="entry name" value="FLUG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED13949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="283" mass="32655" checksum="55893F19D436A24A" modified="2009-03-03" version="1">MSLLPSHPSPSRNSTLRLVHFPQSHLTVRYGSRKILGTVTLQSGGSYTGWSASGVCSREALQQKYDQALTETHATTLYAETTECHIKRMEKLWTDTLLMRSDIALSCAIFNLEPRETLRECQTARIENFLHWVLRTCTIKKTSAVTTYWRQLSQLHITWWQCRISPQTLKEIFVFIEGPLTKEYGLDNTESEKPLLEAEEFMEVIQCHWAADINIFPNERQRVQVAAILLLAAYTGSRPGALLHITYRDLRLYVEKHRRTGKHELKLKVTLTKTKSGQKRKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8MN36</accession>
    <name>B8MN36_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_102150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486223.1">
        <property type="nucleotide sequence ID" value="XM_002486178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MN36"/>
    <dbReference type="STRING" id="441959.B8MN36"/>
    <dbReference type="GeneID" id="8099260"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_102150"/>
    <dbReference type="eggNOG" id="ENOG502RJXA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1310827_0_0_1"/>
    <dbReference type="InParanoid" id="B8MN36"/>
    <dbReference type="OrthoDB" id="4225804at2759"/>
    <dbReference type="PhylomeDB" id="B8MN36"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED13985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23968" checksum="7F57BA574425B644" modified="2009-03-03" version="1">MPNLTIEEIEQKIFEAKLWKAPGEDGLPVMRPISLLSTLGKILEVVIAERILYAIETFSLLPTNHFGARKRHSAEQALLLLQEEIYKAWRNRKYVTRRLLAALQTHANARRYDQAQKIKAKFTKFMQDKGFPVALTEPIERPPIPSYQQVEIDQTISDNQGRAGFNTELEQTVRDFVKTENSAGFSKKHVETIEKALNVYNNLAEACKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNP0</accession>
    <name>B8MNP0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase family hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_103510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486367.1">
        <property type="nucleotide sequence ID" value="XM_002486322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNP0"/>
    <dbReference type="STRING" id="441959.B8MNP0"/>
    <dbReference type="GeneID" id="8103054"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_103510"/>
    <dbReference type="eggNOG" id="ENOG502S2NA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_5_2_1"/>
    <dbReference type="InParanoid" id="B8MNP0"/>
    <dbReference type="OMA" id="IIHIFHS"/>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="PhylomeDB" id="B8MNP0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF1">
        <property type="entry name" value="ISOCHORISMATASE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="10"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED14129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="190" mass="20757" checksum="E49FE912C68ECA05" modified="2009-03-03" version="1">MPPLTFTEPSALVLIDNQFAFNHPTHWGPSRSNPSFEKNLSALLKVFRAARQRKPAVPIYIIHIFHSSLEPGSQLHHSKTDQIKPLDFAVPASDGSEPVFWKSANSSFIGTGLESFLREHGVRQVFFADGSLPEGIRIERGRVVLVADATATFAKGEFDAETVHAVSVASLSEEFADVFTTEAVVEALGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNW9</accession>
    <name>B8MNW9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SNF7 family protein Fti1/Did2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_104280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486446.1">
        <property type="nucleotide sequence ID" value="XM_002486401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNW9"/>
    <dbReference type="FunCoup" id="B8MNW9">
        <property type="interactions" value="698"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MNW9"/>
    <dbReference type="GeneID" id="8103199"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_104280"/>
    <dbReference type="eggNOG" id="KOG3232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1315099_0_0_1"/>
    <dbReference type="InParanoid" id="B8MNW9"/>
    <dbReference type="OMA" id="QQITMVM"/>
    <dbReference type="OrthoDB" id="10266568at2759"/>
    <dbReference type="PhylomeDB" id="B8MNW9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED14208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="213" mass="23177" checksum="AC6E8661281F277B" modified="2009-03-03" version="1">MPVRDPIFEARTNVKLHSNRLKKEALRAEATYKSEKAKADKAMKNREFQIARIHAGSAVREKKRQVNLKAEAARADVIINELKAAQSTRDTSRTLALASRGLDAASKSVNLEHLLAHANNFLARSEDFKIASSAISDVAQGVSQQEYGAEGESEVDKLMEQLADDAGVDLRNALDAVTAAAPKEDVKEHANKHADAEVEDALGARLRALRAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>B8MP33</accession>
    <name>B8MP33_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">H /K ATPase alpha subunit, putative</fullName>
            <ecNumber evidence="12">3.6.3.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_104860</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.9" evidence="12"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486510.1">
        <property type="nucleotide sequence ID" value="XM_002486465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MP33"/>
    <dbReference type="STRING" id="441959.B8MP33"/>
    <dbReference type="GeneID" id="8098707"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_104860"/>
    <dbReference type="eggNOG" id="KOG0203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_4_1_1"/>
    <dbReference type="InParanoid" id="B8MP33"/>
    <dbReference type="OMA" id="QQPPIFN"/>
    <dbReference type="OrthoDB" id="158672at2759"/>
    <dbReference type="PhylomeDB" id="B8MP33"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000114">
        <property type="entry name" value="H /K ATPase alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000147">
        <property type="entry name" value="H/K ATPase alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="343"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="855"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="882"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="929"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="988"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1026"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1057"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="11">
        <location>
            <begin position="99"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED14272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1096" mass="120768" checksum="716A15A620B34A1F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MP68</accession>
    <name>B8MP68_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_105190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486545.1">
        <property type="nucleotide sequence ID" value="XM_002486500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MP68"/>
    <dbReference type="STRING" id="441959.B8MP68"/>
    <dbReference type="GeneID" id="8098740"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_105190"/>
    <dbReference type="eggNOG" id="ENOG502SKBT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_8_0_1"/>
    <dbReference type="InParanoid" id="B8MP68"/>
    <dbReference type="OMA" id="DGMDLEV"/>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="PhylomeDB" id="B8MP68"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF14">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED14307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="356" mass="39662" checksum="023A9E35DB5B242A" modified="2009-03-03" version="1">MSDHKTKIFIIGGTGAQGIPVITGLLTDKKYHCKILTRDPNSPRAKQLAALGGLDISFIQGTFADEQTLKAGFESCDGAFVNIDGFNTGEKTEMFWAIRAYELALESGVKFFVYGNLDYVYKKSGYDPKFRTGHYDGKGRIGEWILQQTQQNGGRMGAALFTTGPYMEMTIAKGTPMTPTVEEGVVTWRVPLGQGAVVHVSLQDSKANGMDLEVAIAHIDYAEMATAFEKVTGHPARYIDTDLETYWSSGPLSRNADAPAGYSADPTDKSTMTMRQNFTGFWNMWKYSGKNAGVVKRDYELLDEIYPDRIKSAEEWFRREDQRGRELGLGGLWERVQKDSIKPVLKIAEDGRRGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8MP86</accession>
    <name>B8MP86_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_105370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486563.1">
        <property type="nucleotide sequence ID" value="XM_002486518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MP86"/>
    <dbReference type="STRING" id="441959.B8MP86"/>
    <dbReference type="GeneID" id="8098758"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_105370"/>
    <dbReference type="eggNOG" id="ENOG502RUBT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089414_0_0_1"/>
    <dbReference type="InParanoid" id="B8MP86"/>
    <dbReference type="OrthoDB" id="4226837at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF6">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED14325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="272" mass="28643" checksum="70D5B1B382B00D64" modified="2009-03-03" version="1">MSGQFIYPPPNSQDVTLNYNYRDSVDVSFQTTAQDPNNTFLSLWYYLDGQPWAIGYNTSVPPNGTITVDLNILDQPYYGQFNYDFDGHKVAYLSCFFNVAHNTTQNPVTWGQSAAAAYSSSLAAATSTITTTTSTTTTSAASKGTSTSTSTRSATTVGSLGSAASVISSPSSTPSSSGLSGGAIAGIVVGVVIGVLAVLGMGLFFWRRNRNGNKSAEILASGSQHSPLPQQQELDNNQVEKPLGSVSMYSHHGGLPRYAELAGNNGLQELPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPW8</accession>
    <name>B8MPW8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lectin family integral membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_053720</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486969.1">
        <property type="nucleotide sequence ID" value="XM_002486924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPW8"/>
    <dbReference type="FunCoup" id="B8MPW8">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MPW8"/>
    <dbReference type="GeneID" id="8098323"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_053720"/>
    <dbReference type="eggNOG" id="ENOG502QR1C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053733_0_0_1"/>
    <dbReference type="InParanoid" id="B8MPW8"/>
    <dbReference type="OMA" id="WYTSERG"/>
    <dbReference type="OrthoDB" id="10265193at2759"/>
    <dbReference type="PhylomeDB" id="B8MPW8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06903">
        <property type="entry name" value="lectin_EMP46_EMP47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035661">
        <property type="entry name" value="EMP46/EMP47_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF28">
        <property type="entry name" value="LECTIN, MANNOSE BINDING 1 LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012768073" evidence="8">
        <location>
            <begin position="16"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="9">
        <location>
            <begin position="16"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="276"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED12858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="412" mass="45514" checksum="4EBCE90DB4AA0509" modified="2009-03-03" version="1">MKYSFALAFLTAVSAQSIIDTLSFGHGSRFSPSGDSLPGWKIKGEGHEPQILSDKLILTPPYPGHTRGSIWAENGLSLSEWTTEFHFRASGEERGSGNLQLWYVKDGERTVGASSIYTVGQFDGFVLTIDTHGGRGGSIRGFLNDGTRAYNQHTNVDSLAFGHCDYAYRNLGRPSVIKIEQSSSLFQVTVDDKVCFQTPKVALPAGNVFGVTAATPDNPDSFEIFKFVVTSGAQATAHFGGQTTQQQQAPIEGRSTSNQINLGSLDDMNNRIYQISQEVSQIVQNMNERHQELLNRISTGSASSSSDSSPQSDARLNAIDDRLRRIETMLSDIQRDNAGKDYRNEFTRLHKAIEHSHVSLTEALQTSIFNMITATTPRMGLFICVVIAFQLFLAGAYVYYKRRRNGMPKKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQA5</accession>
    <name>B8MQA5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_057430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487363.1">
        <property type="nucleotide sequence ID" value="XM_002487318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQA5"/>
    <dbReference type="STRING" id="441959.B8MQA5"/>
    <dbReference type="GeneID" id="8108879"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_057430"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_0_1"/>
    <dbReference type="InParanoid" id="B8MQA5"/>
    <dbReference type="OMA" id="RFHDWNF"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="PhylomeDB" id="B8MQA5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF283">
        <property type="entry name" value="RETINOL DEHYDROGENASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED13252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="330" mass="36460" checksum="5869549C22D644A7" modified="2009-03-03" version="1">MSSYTRETDGDQIASDLSSTIKGKSILITGVSPGGLGAEFAITISKHFPRLLILAGRDVKKAEQTAAKIAEVAPTVEVRTLKLDLASQSQVREAAQEVNAYKEPGYIDVLVNNAGIMATMPYTQTVERIESQFGTNHIGHFLFTNLIMEKLIGADGSARTARVVNVSSDGYRLGHVRFDDWNFDNGTTYNPWRAYGQSKTANMLFSRSLAAKLADRGLISVSLHPGVILDTNLSGHLDASGFQGLLEVDRQQGNRKYWGPFKGKTPLQGVSTHVFASFHDSIMLTNNNGVYLEDNRVFRPEEVLTWGRDDIEAQKLWKLSEELVGEKFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQC3</accession>
    <name>B8MQC3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit D</fullName>
            <shortName evidence="5">eIF3d</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_058140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit D family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487436.1">
        <property type="nucleotide sequence ID" value="XM_002487391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQC3"/>
    <dbReference type="STRING" id="441959.B8MQC3"/>
    <dbReference type="GeneID" id="8109235"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_058140"/>
    <dbReference type="eggNOG" id="KOG2479">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024521_2_0_1"/>
    <dbReference type="InParanoid" id="B8MQC3"/>
    <dbReference type="OMA" id="FMDKRDN"/>
    <dbReference type="OrthoDB" id="16538at2759"/>
    <dbReference type="PhylomeDB" id="B8MQC3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098808">
        <property type="term" value="F:mRNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002191">
        <property type="term" value="P:cap-dependent translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03003">
        <property type="entry name" value="eIF3d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007783">
        <property type="entry name" value="eIF3d"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05091">
        <property type="entry name" value="eIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016281">
        <property type="entry name" value="EIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="104"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA gate" evidence="5">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED13325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="583" mass="64780" checksum="58C8DA44AB93DBAB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQG6</accession>
    <name>B8MQG6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Efflux pump antibiotic resistance protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_058570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487479.1">
        <property type="nucleotide sequence ID" value="XM_002487434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQG6"/>
    <dbReference type="GeneID" id="8106459"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_058570"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="InParanoid" id="B8MQG6"/>
    <dbReference type="OMA" id="DVYVMAI"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="PhylomeDB" id="B8MQG6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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</entry>
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            <authorList>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MR24</accession>
    <name>B8MR24_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar O-acetyltransferase, putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">TSTA_054300</name>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487030.1">
        <property type="nucleotide sequence ID" value="XM_002486985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MR24"/>
    <dbReference type="FunCoup" id="B8MR24">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MR24"/>
    <dbReference type="GeneID" id="8100369"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_054300"/>
    <dbReference type="eggNOG" id="KOG4750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_3_0_1"/>
    <dbReference type="InParanoid" id="B8MR24"/>
    <dbReference type="OMA" id="KVAQFNI"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="PhylomeDB" id="B8MR24"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03357">
        <property type="entry name" value="LbH_MAT_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000025">
        <property type="entry name" value="Hexapeptide-repeat containing-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF23">
        <property type="entry name" value="ACETYLTRANSFERASE C18B11.09C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Maltose/galactoside acetyltransferase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED12919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="217" mass="24084" checksum="9AA9BF7D01F57780" modified="2009-03-03" version="1">MACTEKKQDFIALAEALTNTPWCDDYEKMISGMFYDSFVPELVEGRLRARKLVKKYNDYLPDDATNESLNKDREIMLKEFIGRVGKGVCIDPPFRVDYGCNIIIGDEFYANFNMVILDCAIVKIGDRVKFGPNVSVFAAIHPTEVQARRETPDYSKEVTIGNDCWIGGHTVIMPGVTIGDGVTIGASSVVTRGIPSYSIALGSPARVIKRVESVDMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRA2</accession>
    <name>B8MRA2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BAR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_055040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487108.1">
        <property type="nucleotide sequence ID" value="XM_002487063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRA2"/>
    <dbReference type="STRING" id="441959.B8MRA2"/>
    <dbReference type="GeneID" id="8100510"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_055040"/>
    <dbReference type="eggNOG" id="KOG1118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034817_1_0_1"/>
    <dbReference type="InParanoid" id="B8MRA2"/>
    <dbReference type="OMA" id="KSMTSYV"/>
    <dbReference type="OrthoDB" id="14167at2759"/>
    <dbReference type="PhylomeDB" id="B8MRA2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07593">
        <property type="entry name" value="BAR_MUG137_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="3">
        <location>
            <begin position="15"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="126"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED12997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="420" mass="47505" checksum="397B311154EAC462" modified="2009-03-03" version="1">MNVNKKLDRFKQWAGERMGGEVKTNVSDDFKALETEMNLRHDGMEKMHRSMTAYVKAISKRKEGDDKEKTLPIAHLGSVMIQHGEDFDSQSEFGRSLTLTGKAHERLARIQESYSVQASTSWLEALERSLASLKEYQNARKKLESRRLAYDASLAKMQKAKKEDFRVEEELRSQKAKYEETNDDVYRRMMDIQDAEGENLADLTAFIDAELNYHERSREVLLQLRNELPTANPPASHANSHRPSRARSNTAHSYQERYEPVVEVAPPSPPRPTIRSRRSSTFYPQNDETPQARPEYSRPAFNRVSTYDGSTHESPSTYTPNRVHNDLSIRSARTNLRPVSKIHEDYQDSSSYGNVSPYDDRSESSATSQGGYFSRTPSSSALNSVSPATKKGPPPPPPSRATKPKPPPPPPPVKRNLIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRX1</accession>
    <name>B8MRX1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_057940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487416.1">
        <property type="nucleotide sequence ID" value="XM_002487371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRX1"/>
    <dbReference type="STRING" id="441959.B8MRX1"/>
    <dbReference type="GeneID" id="8108930"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_057940"/>
    <dbReference type="HOGENOM" id="CLU_2456287_0_0_1"/>
    <dbReference type="InParanoid" id="B8MRX1"/>
    <dbReference type="OrthoDB" id="4222077at2759"/>
    <dbReference type="PhylomeDB" id="B8MRX1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED13305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="89" mass="10555" checksum="8880CC4F62BE47DA" modified="2009-03-03" version="1">MFWKVFRLVRERATGDKIDPITTRQMKRVIRHLSKKYQLEKSCEKLVIYVEDPAKVVETTVVTTRKKFGHGHHWIELYLFLQLAGLAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B8MS05</accession>
    <name>B8MS05_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_001220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487704.1">
        <property type="nucleotide sequence ID" value="XM_002487659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MS05"/>
    <dbReference type="GeneID" id="8098616"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_001220"/>
    <dbReference type="eggNOG" id="ENOG502SECT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1157045_0_0_1"/>
    <dbReference type="InParanoid" id="B8MS05"/>
    <dbReference type="OrthoDB" id="4509841at2759"/>
    <dbReference type="PhylomeDB" id="B8MS05"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED12050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="240" mass="26156" checksum="C27764910746EC6E" modified="2009-03-03" version="1">MAQARMLTPSTGENLHPQRRVLIRAGAQQPPPPPPITNQQRPIKTYTKMEDLAKAAELLAQYIYLNPREGQDNPMIRGFINDVQDFTTAHKSGPEILTDLKRLLVDVQKDTAVLRTRSNQASQSSATTGLLSASLRSTAAPSSRSAGFSTPGVSHTELSIDCEIVIKIRDEAIHKEIRELHPVEIVKRAERARAHAAKGTPSLPLAGHVFIAARPLLLGDVSLQALNAAAAEVLRRHAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTR2</accession>
    <name>B8MTR2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_005760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488201.1">
        <property type="nucleotide sequence ID" value="XM_002488156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTR2"/>
    <dbReference type="STRING" id="441959.B8MTR2"/>
    <dbReference type="GeneID" id="8105550"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_005760"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_8_2_1"/>
    <dbReference type="InParanoid" id="B8MTR2"/>
    <dbReference type="OMA" id="IMTEMTE"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="PhylomeDB" id="B8MTR2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="3">
        <location>
            <begin position="31"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED12547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="284" mass="30402" checksum="3E1FE6E0FD2CE22D" modified="2009-03-03" version="1">MATFPSLTKTWHTVPYPAISPLKPLLSAADKTILITGGGGGIGAGIARAFAAAGSTQIAIIGRRQDVLATTAKELEASFNGLRVIGCVTDVSKKEQIDAAFDLVVNKFGPIDVFVDNAGYVTTGTVTELSNDDAWITFETNMKGSIYTAQAFSRTARKDHAVVIDVSSIAAIMPPLPGAAAYSTSKLAATKIWEYFAAENPNYRVVSIQPGQIETDMAKKLGLTGRDHVNLPSQFAVWLASSEADFLHGKFVCANWDVEELIARKEEFKTTDLGTIRLVGLPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUG0</accession>
    <name>B8MUG0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_109790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488555.1">
        <property type="nucleotide sequence ID" value="XM_002488510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUG0"/>
    <dbReference type="STRING" id="441959.B8MUG0"/>
    <dbReference type="GeneID" id="8107211"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109790"/>
    <dbReference type="eggNOG" id="KOG1121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1735920_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUG0"/>
    <dbReference type="OrthoDB" id="4837779at2759"/>
    <dbReference type="PhylomeDB" id="B8MUG0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED11799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="169" mass="18800" checksum="82B479FB86847CBA" modified="2009-03-03" version="1" fragment="single">CQGPLSSWISKEKKLPFEEALLNWIISTSQPFTCVEQPSFKTMLRSAGSQDSIPSADTISRRLSLWLDAVDSELRGLMSSASSIALSLNGWTSQNSLPMLAINAHWMSSDFQQYRACIEFVEIEGNHSGENLANIVATALQRFHISDKVITITADNASNNDTLHRYLHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8MV11</accession>
    <name>B8MV11_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ankyrin repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_110800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488657.1">
        <property type="nucleotide sequence ID" value="XM_002488612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MV11"/>
    <dbReference type="GeneID" id="8101452"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_110800"/>
    <dbReference type="HOGENOM" id="CLU_513060_0_0_1"/>
    <dbReference type="InParanoid" id="B8MV11"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="PhylomeDB" id="B8MV11"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="61145" checksum="C123B5BFF6191A23" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8MVA0</accession>
    <name>B8MVA0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GRF-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_008520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962662">
        <property type="protein sequence ID" value="EED11556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488737.1">
        <property type="nucleotide sequence ID" value="XM_002488692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MVA0"/>
    <dbReference type="STRING" id="441959.B8MVA0"/>
    <dbReference type="GeneID" id="8103240"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_008520"/>
    <dbReference type="eggNOG" id="KOG1294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1778714_0_0_1"/>
    <dbReference type="InParanoid" id="B8MVA0"/>
    <dbReference type="OrthoDB" id="391817at2759"/>
    <dbReference type="PhylomeDB" id="B8MVA0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="6">
        <location>
            <begin position="106"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="17"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED11556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="146" mass="16115" checksum="0FCAFD995C1AAB64" modified="2009-03-03" version="1">MNTTKAESLAERKTRFLSMVECKNPDQDTNNTQEISNRGLDDAFKTSPTKSIPPVSSSPQKPIPTSRTTVQDGGSTTESTDETVIDPIVSKESWSKLFAKKATPKCEEYQEPCIMLTTKKPGVNCGQAFWMCSRPLDPTGQKHKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTT3</accession>
    <name>B8LTT3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytokinesis protein sepH</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Serine/threonine-protein kinase sepH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TSTA_070810</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Required for early events during cytokinesis including localization of cytoskeletal components to the cytokinetic ring.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341062.1">
        <property type="nucleotide sequence ID" value="XM_002341021.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LTT3"/>
    <dbReference type="GeneID" id="8102462"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_070810"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001872_1_1_1"/>
    <dbReference type="InParanoid" id="B8LTT3"/>
    <dbReference type="OMA" id="VKQIKLV"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="PhylomeDB" id="B8LTT3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06627">
        <property type="entry name" value="STKc_Cdc7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000176">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000212">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000246">
        <property type="entry name" value="Putative Serine-threonine kinase SepH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF26">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DDB_G0283821-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="55"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="333"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="435"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="559"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1202"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="435"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1212"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1262"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1289"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EED23675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1329" mass="148259" checksum="9639270944165CC3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTV5</accession>
    <name>B8LTV5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_071810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341172.1">
        <property type="nucleotide sequence ID" value="XM_002341131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTV5"/>
    <dbReference type="STRING" id="441959.B8LTV5"/>
    <dbReference type="GeneID" id="8102630"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_071810"/>
    <dbReference type="eggNOG" id="ENOG502T5I4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1125162_0_0_1"/>
    <dbReference type="InParanoid" id="B8LTV5"/>
    <dbReference type="OMA" id="CHYISIH"/>
    <dbReference type="OrthoDB" id="3555317at2759"/>
    <dbReference type="PhylomeDB" id="B8LTV5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="27818" checksum="0347B4F5BE6A9E5D" modified="2009-03-03" version="1">MACEDTSKELPFPSWGSDSAYDYPSLLDEAVESLEIASPTSTENGSQKFDSPPEAGATKPVCKSRKRGRPRLIRDDRREADLKERRKDQLRLAQRAYRSRKEDQITMLNKKVADLEQKLFLLRNLYLNTCATSMNSDVLREWPTNSKSPQDSLELLTPNSGIDEASIAAYGGHAKSIPSIPVGESYPLFEMNNPLRPEMSPIGLLDMPYLLFNDNNYVGGTPAWRVRYSDHSNDIQNNADYLLGLPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8LU49</accession>
    <name>B8LU49_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_060180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002339908.1">
        <property type="nucleotide sequence ID" value="XM_002339867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LU49"/>
    <dbReference type="GeneID" id="8102643"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_060180"/>
    <dbReference type="eggNOG" id="ENOG502T3Q0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_455062_0_0_1"/>
    <dbReference type="InParanoid" id="B8LU49"/>
    <dbReference type="OrthoDB" id="4509088at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="600" mass="67704" checksum="4AE2AD78921EB317" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-03" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUH2</accession>
    <name>MAP21_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methionine aminopeptidase 2-1</fullName>
            <shortName evidence="1">MAP 2-1</shortName>
            <shortName evidence="1">MetAP 2-1</shortName>
            <ecNumber evidence="1">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">TSTA_071420</name>
    </gene>
    <organism>
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="1">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="1"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341132.1">
        <property type="nucleotide sequence ID" value="XM_002341091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUH2"/>
    <dbReference type="SMR" id="B8LUH2"/>
    <dbReference type="FunCoup" id="B8LUH2">
        <property type="interactions" value="1183"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LUH2"/>
    <dbReference type="GeneID" id="8102525"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_071420"/>
    <dbReference type="eggNOG" id="KOG2775">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_7_1_1"/>
    <dbReference type="InParanoid" id="B8LUH2"/>
    <dbReference type="OMA" id="PFAKRWL"/>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="PhylomeDB" id="B8LUH2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000370">
        <property type="entry name" value="Methionine aminopeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0031">Aminopeptidase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000407614" description="Methionine aminopeptidase 2-1">
        <location>
            <begin position="1"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="443" mass="48965" checksum="9838CC94CA68A14A" modified="2009-03-03" version="1">MAAQADDELNKLRLNGQNGEAKEQVSASAVDTADNDDSEDDEKEEEGGAEVAATEAAKKKKKRKPKKKKKGGAKKQSSPPRVPVSELFPNNQYPEGEIVEYKDENNYRTTNEEKRYLDRMNNDFLQEYRQGAEVHRQVRQYAQKNIKPGQTLTEIAEGIEDAVRALTGHQGLEEGDNIKGGMGFPCGLSINHCAAHYTPNAGNKMVLQQGDVMKVDFGAHINGRIVDSAFTMTFDPVYDNLLTAVKEATNTGIREAGIDVRMSDIGAAIQEVMESYEVEINGTTYPVKAIRNLNGHNIDQHVIHGGKSVPIVKGGDQTKMEEGEVFAIETFGSTGKGYVREDMETSHYAKAQDAPNVSLRLSSAKNLLNVINKNFGTLPFCRRYLDRLGQDKYLLGLNNLVSAGIVQDYPPLCDIKGSYTAQYEHTIVLRPTVKEVISRGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWF5</accession>
    <name>B8LWF5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_076340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341653.1">
        <property type="nucleotide sequence ID" value="XM_002341612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWF5"/>
    <dbReference type="FunCoup" id="B8LWF5">
        <property type="interactions" value="279"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LWF5"/>
    <dbReference type="GeneID" id="8099351"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_076340"/>
    <dbReference type="eggNOG" id="ENOG502QSAH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040959_2_1_1"/>
    <dbReference type="InParanoid" id="B8LWF5"/>
    <dbReference type="OMA" id="ETYMTDL"/>
    <dbReference type="OrthoDB" id="1914839at2759"/>
    <dbReference type="PhylomeDB" id="B8LWF5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24142">
        <property type="entry name" value="ACL4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF50">
        <property type="entry name" value="ASSEMBLY CHAPERONE OF RPL4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="354"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED24266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="400" mass="44663" checksum="408AF230EA163944" modified="2009-03-03" version="1">MGKSRTKNKKSSTKSEKSVLHSVGKVVSKRKMADNATELLEKATILLQTGQAEAALPLAQRILEISEENSADSLSAINLVGEIYVELGEIDAARESFLHAVQLDPEGTIPESQGGGAEKFLWLAQLSEQGGADSVAWYEKGVGALRHIIQSLEQNGGSDTASILDEKRKKLAVALCGVVELYMTDLSWEEDAESRCETLITEALLVAPDQPDCLQTLASVRISQARIDDARAALSRSLELWQDLPPEDPKIPDFPSRISLSRLLMEVQMEVEALQVLERLILEDDESVEAWYLGGWCLYLLAEKEKQDSSEEKRHESMVASREWLKQSLKLYQKLEYEDERLRDHALELVQELNKELGDDMDDDSDDGPVFPGGDEDEEDWDGEIEAESDDDEDHEMKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWK0</accession>
    <name>B8LWK0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SNF7 family protein (Cta1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_077570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341784.1">
        <property type="nucleotide sequence ID" value="XM_002341743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWK0"/>
    <dbReference type="FunCoup" id="B8LWK0">
        <property type="interactions" value="366"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LWK0"/>
    <dbReference type="GeneID" id="8101961"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_077570"/>
    <dbReference type="eggNOG" id="KOG1655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079409_0_0_1"/>
    <dbReference type="InParanoid" id="B8LWK0"/>
    <dbReference type="OMA" id="GVKQMQK"/>
    <dbReference type="OrthoDB" id="3973241at2759"/>
    <dbReference type="PhylomeDB" id="B8LWK0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF12">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED24397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="218" mass="24302" checksum="D908C2FCC3E9AE3D" modified="2009-03-03" version="1">MNRLFGTKNQAPKPTLDSAISNVDSRVSSIDVKLAALNSELSTYQARLSKMRDGPGKNALRQKALKVLQRRKQYEAQRDQLSQQSWNMEQANMMQDNLKNVMTTVDAMKTTTKALKKQYGKIDIDKIERMQDEMADLMDIGNEINESISRAYDIPEDVDEAELDAELEALGEESLFENPMMGDSEAVPSFLQDEVAPPSFIDEPPEQGKVKEAAGGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWU2</accession>
    <name>B8LWU2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_079310</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341962.1">
        <property type="nucleotide sequence ID" value="XM_002341921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWU2"/>
    <dbReference type="STRING" id="441959.B8LWU2"/>
    <dbReference type="GeneID" id="8107610"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_079310"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_19_0_1"/>
    <dbReference type="InParanoid" id="B8LWU2"/>
    <dbReference type="OMA" id="LAYCEIN"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="PhylomeDB" id="B8LWU2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED24575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="130" mass="15022" checksum="C1F7D79A66540CE2" modified="2009-03-03" version="1">MHRLPRVSPDVSIQYKQWTIPKGVPVGMSAYLMHMDGDIYKDPSKFMPERWLDSKPLLDRNYVPFSRGSRKCLGINLAYAELYLVLAVLFRPGEPQFELFETDESDVVQVHDFLLPLPRLDSKGIRVTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWU7</accession>
    <name>B8LWU7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_079350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341967.1">
        <property type="nucleotide sequence ID" value="XM_002341926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWU7"/>
    <dbReference type="STRING" id="441959.B8LWU7"/>
    <dbReference type="GeneID" id="8107622"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_079350"/>
    <dbReference type="eggNOG" id="ENOG502SZ1T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_894557_0_0_1"/>
    <dbReference type="InParanoid" id="B8LWU7"/>
    <dbReference type="OMA" id="YWEPLVA"/>
    <dbReference type="OrthoDB" id="4670414at2759"/>
    <dbReference type="PhylomeDB" id="B8LWU7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED24580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="363" mass="40856" checksum="7E2A701EC4DEC85B" modified="2009-03-03" version="1">MDDDSFYLYGVGEKPDALTLGSLVLEKYWMPLIARHYTHDPLRGQDLEENVWSSKLENLVLHGRTRLSPGVGVSGFDIVDLKLAWNKDQERFVTASSGQKLTLKDPEAFLSNHVLMNPKARSALKLWLSSARSDYVMNMRWARRPKIWFLTGLYILKGARTIVRKQSSSTIEVGLNSAIVGALSGVPIGGSVSLGQGDAWELQMGMEEEHVWAAQYRLIDAKYIAVSSRTRSEVMALPATMSLYKDILSVRNRRTTSQLAGRNLDMDVEVGLQPPFYRARPMKTVTDLDSMFDSVPARAPITAVPYDSTSGLTEVITLVPEEGKLELDDDDDEESEESFEEYEKRLEDAIRMFEAAPPRFLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXG9</accession>
    <name>B8LXG9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unc-44 ankyrin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_066930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340637.1">
        <property type="nucleotide sequence ID" value="XM_002340596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXG9"/>
    <dbReference type="STRING" id="441959.B8LXG9"/>
    <dbReference type="GeneID" id="8102523"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_066930"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024130_0_0_1"/>
    <dbReference type="InParanoid" id="B8LXG9"/>
    <dbReference type="OMA" id="WELTALH"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="PhylomeDB" id="B8LXG9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="381"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="447"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="480"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="539" mass="58041" checksum="48A05A3746EB2C84" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXM2</accession>
    <name>B8LXM2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Calnexin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_078780</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the calreticulin family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341910.1">
        <property type="nucleotide sequence ID" value="XM_002341869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXM2"/>
    <dbReference type="STRING" id="441959.B8LXM2"/>
    <dbReference type="GeneID" id="8102631"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_078780"/>
    <dbReference type="eggNOG" id="KOG0675">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018224_1_2_1"/>
    <dbReference type="InParanoid" id="B8LXM2"/>
    <dbReference type="OMA" id="SGCGKWE"/>
    <dbReference type="OrthoDB" id="1938156at2759"/>
    <dbReference type="PhylomeDB" id="B8LXM2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000001">
        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000011">
        <property type="entry name" value="Probable calnexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF1">
        <property type="entry name" value="CALNEXIN 14D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00803">
        <property type="entry name" value="CALRETICULIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00805">
        <property type="entry name" value="CALRETICULIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005124055" evidence="9">
        <location>
            <begin position="24"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="242"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="519"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="253"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="524"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="553"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="143"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601580-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED24523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="563" mass="61959" checksum="D9E84F0EE5658122" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXZ9</accession>
    <name>B8LXZ9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation initiation factor 4B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_063010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340201.1">
        <property type="nucleotide sequence ID" value="XM_002340160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXZ9"/>
    <dbReference type="STRING" id="441959.B8LXZ9"/>
    <dbReference type="GeneID" id="8100201"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_063010"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030044_0_1_1"/>
    <dbReference type="InParanoid" id="B8LXZ9"/>
    <dbReference type="OMA" id="WTTVPNK"/>
    <dbReference type="OrthoDB" id="48651at2759"/>
    <dbReference type="PhylomeDB" id="B8LXZ9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
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        <property type="term" value="F:translation initiation factor activity"/>
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        <property type="entry name" value="RRM_dom"/>
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        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
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    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="73"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="17"/>
            <end position="71"/>
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        <location>
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            <end position="216"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="272"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
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            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
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            <end position="328"/>
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        <location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
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            <dbReference type="EMBL" id="EED22814.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="486" mass="53144" checksum="8C69CC7EAF9D8F0C" modified="2009-03-03" version="1">MSIGTFLADENFGSWADEMEDMPLPAAPEPRSTYGGERRAISSTAGFGNGFNDRERPAFSSRPELPLPTEPPFTAHIGNLSFDATSSDVSQLFADCEVTNVRIVEDKLNRSPKGFGYVEFATVEGLKKALTFSGTTLQGRAIRVSIAEPPKDSGSSRDFSDWSRKGPLPDLPRRESNRSFNRDFPDNVSESGSTRGGRRFESDGKVRDFGNWERKGPLSPVAAVAGREGGRPRSNEGSNFRKNSPAWGEGRSQDGSRPPRREFQERPERPERTPTAAEMDNQWRARMRPDPPAPKEPSAPSSPVPTPAAPAVRPKLNLQKRTVSENVQSPPPSATGDSKASPFGAARPIDTAAREQEVVAKRERARKEAEEKAKAEKAEKQRQSKEKAKAEKSATGDSNGTKETDPDAPKKSNFEVLRRAADEDGGENEAEESKEESTAAKEQPKEAADSKTNGSWRKAEPAAAEADEEGWSTVSTNKRNKGRGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8LY28</accession>
    <name>B8LY28_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">26S proteasome regulatory subunit RPN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_067140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proteasome subunit S2 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_067140"/>
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    <dbReference type="HOGENOM" id="CLU_008705_1_0_1"/>
    <dbReference type="InParanoid" id="B8LY28"/>
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    <dbReference type="OrthoDB" id="10252509at2759"/>
    <dbReference type="PhylomeDB" id="B8LY28"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:enzyme regulator activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0030674">
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:regulation of protein catabolic process"/>
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    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="26S_Psome_Rpn1"/>
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    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
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        <property type="entry name" value="RPN1_C"/>
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        <property type="entry name" value="RPN1_N"/>
    </dbReference>
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        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
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    </dbReference>
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        <property type="entry name" value="26S_Psome_Rpn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RPN1 N-terminal" evidence="7">
        <location>
            <begin position="65"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit RPN1 C-terminal" evidence="8">
        <location>
            <begin position="852"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED23273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="909" mass="101304" checksum="A2916505052C7CF1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8LY57</accession>
    <name>B8LY57_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Plasma membrane antiporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_067390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340689.1">
        <property type="nucleotide sequence ID" value="XM_002340648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LY57"/>
    <dbReference type="STRING" id="441959.B8LY57"/>
    <dbReference type="GeneID" id="8101228"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_067390"/>
    <dbReference type="eggNOG" id="KOG4505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008635_4_1_1"/>
    <dbReference type="InParanoid" id="B8LY57"/>
    <dbReference type="OMA" id="KIKQRWY"/>
    <dbReference type="OrthoDB" id="5327978at2759"/>
    <dbReference type="PhylomeDB" id="B8LY57"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF5">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="7">
        <location>
            <begin position="33"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="518"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="614"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED23302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="653" mass="73060" checksum="0A5E0F92E441072E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYW2</accession>
    <name>B8LYW2_TALSN</name>
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        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_068940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYW2"/>
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    </dbReference>
    <dbReference type="STRING" id="441959.B8LYW2"/>
    <dbReference type="GeneID" id="8108547"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_068940"/>
    <dbReference type="eggNOG" id="KOG2165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007149_0_0_1"/>
    <dbReference type="InParanoid" id="B8LYW2"/>
    <dbReference type="OMA" id="VTTWQAT"/>
    <dbReference type="OrthoDB" id="5581181at2759"/>
    <dbReference type="PhylomeDB" id="B8LYW2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Anaphase-promoting complex subunit ApcB"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000013">
        <property type="entry name" value="Anaphase-promoting complex subunit ApcB, putative"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR036317">
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR_ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="APC2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="570"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED23470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="913" mass="102313" checksum="0DF9D8E4F538D786" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZ11</accession>
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        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="11" type="ORF">TSTA_082880</name>
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    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002477973.1"/>
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    <dbReference type="AlphaFoldDB" id="B8LZ11"/>
    <dbReference type="STRING" id="441959.B8LZ11"/>
    <dbReference type="GeneID" id="8105166"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_082880"/>
    <dbReference type="eggNOG" id="ENOG502SIEZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_264019_0_0_1"/>
    <dbReference type="InParanoid" id="B8LZ11"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="PhylomeDB" id="B8LZ11"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF20">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="99"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="10">
        <location>
            <begin position="614"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="HTH CENPB-type" evidence="9">
        <location>
            <begin position="870"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="DDE-1" evidence="8">
        <location>
            <begin position="971"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="499"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED21055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1270" mass="143485" checksum="81B0D7E3AD95B4FE" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZ36</accession>
    <name>B8LZ36_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SWI/SNF family DNA-dependent ATPase Ris1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_083130</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478043.1">
        <property type="nucleotide sequence ID" value="XM_002477998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZ36"/>
    <dbReference type="STRING" id="441959.B8LZ36"/>
    <dbReference type="GeneID" id="8105191"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_083130"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_2_0_1"/>
    <dbReference type="InParanoid" id="B8LZ36"/>
    <dbReference type="OMA" id="CHPHLIN"/>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="PhylomeDB" id="B8LZ36"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002380">
        <property type="entry name" value="SWI/SNF family DNA-dependent ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF16">
        <property type="entry name" value="ATP-DEPENDENT HELICASE ULS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="432"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="780"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="974"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="847"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="853"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="905"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="918"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED21080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1146" mass="128881" checksum="962DA03BF224B8EA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZJ0</accession>
    <name>B8LZJ0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CwfJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_093180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479035.1">
        <property type="nucleotide sequence ID" value="XM_002478990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZJ0"/>
    <dbReference type="FunCoup" id="B8LZJ0">
        <property type="interactions" value="1113"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LZJ0"/>
    <dbReference type="GeneID" id="8102562"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_093180"/>
    <dbReference type="eggNOG" id="KOG2476">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019955_3_0_1"/>
    <dbReference type="InParanoid" id="B8LZJ0"/>
    <dbReference type="OMA" id="IVPITHY"/>
    <dbReference type="OrthoDB" id="444325at2759"/>
    <dbReference type="PhylomeDB" id="B8LZJ0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061632">
        <property type="term" value="F:RNA lariat debranching enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07380">
        <property type="entry name" value="MPP_CWF19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF4">
        <property type="entry name" value="CWF19-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="3">
        <location>
            <begin position="317"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="2">
        <location>
            <begin position="501"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED22072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="567" mass="63515" checksum="1BDBEF868F64B8EF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZM2</accession>
    <name>B8LZM2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Malonyl CoA-acyl carrier protein transacylase, putative</fullName>
            <ecNumber evidence="21">2.3.1.38</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TSTA_096940</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15057"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9924"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78783"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41788"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="EC" id="2.3.1.38"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the fungal fatty acid synthetase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.38" evidence="21"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479408.1">
        <property type="nucleotide sequence ID" value="XM_002479363.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LZM2"/>
    <dbReference type="GeneID" id="8103537"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_096940"/>
    <dbReference type="eggNOG" id="ENOG502QQJX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000114_5_0_1"/>
    <dbReference type="InParanoid" id="B8LZM2"/>
    <dbReference type="OrthoDB" id="5417908at2759"/>
    <dbReference type="PhylomeDB" id="B8LZM2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004313">
        <property type="term" value="F:[acyl-carrier-protein] S-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:fatty acyl-[ACP] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03447">
        <property type="entry name" value="FAS_MaoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000078">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.100:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000006">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000003">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="FAS1-like_DH_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016452">
        <property type="entry name" value="Fas1/AflB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013565">
        <property type="entry name" value="Fas1/AflB-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041099">
        <property type="entry name" value="FAS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040883">
        <property type="entry name" value="FAS_meander"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08354">
        <property type="entry name" value="Fas1-AflB-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="FAS1_DH_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22235">
        <property type="entry name" value="FAS1_thioest_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17951">
        <property type="entry name" value="FAS_meander"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17828">
        <property type="entry name" value="FAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005562">
        <property type="entry name" value="FAS_yeast_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="21" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 17" id="KW-0520">NAD</keyword>
    <keyword evidence="6 17" id="KW-0521">NADP</keyword>
    <keyword evidence="7 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17 21" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="20">
        <location>
            <begin position="1683"/>
            <end position="2005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="active site" description="For acetyltransferase activity" evidence="18">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="active site" description="For malonyltransferase activity" evidence="18">
        <location>
            <position position="1821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR005562-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EED22445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="2086" mass="232833" checksum="7ADD9B84A53C56AF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZT2</accession>
    <name>B8LZT2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glucanase</fullName>
            <ecNumber evidence="12">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSTA_080970</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Has endoglucanase activity on substrates containing beta-1,4 glycosidic bonds, like in carboxymethylcellulose (CMC), hydroxyethylcellulose (HEC) and beta-glucan. Involved in the degradation of complex natural cellulosic substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
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        <text evidence="2 12">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
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    </dbReference>
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    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="4 12 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877203" description="Glucanase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="15">
        <location>
            <begin position="439"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="405"/>
            <end position="440"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00025192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
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            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EED20864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="475" mass="49321" checksum="BD418B81D755F7E8" modified="2009-03-03" version="1">MATKVLGFAAIAALFHKVTCQQAPTPDNIASLLTWKCTNSGGCIQQSTSIVVDWVYHWIHTVNGSTSCTTSSGLDSNLCGSEQECYANCEISPATYDSLGIKTSGNALTLNQYVTSNDNAGKNYEMLQLLSQEISFDVDVSNLPCGENGALYLSEMDVTGGRSQYNPAGASYGSGYCDAQCGTGTWFNGSINSGGLGSCCNEMDLWEANSKATALTPHPCSVEGPYGCSGSACGSTGVCDKNGCGFNPYALGDQSYYGQGFIVDTSKPFTVTTQFVTSDNSKTGTLTEIRRSYVQNGKVIANAVASASSGFSGANSITESFCTTMDSEAGTLGGLNTMGEALSRGMVLIFSIWNDAGGYMNWLDSGNSGPCSSTAGIPSTIEANDPGTSVTFSNIKWGDIGSTVSDTGGSGSSSSSLISTKTSSTTTTSATRTATSSGATQTHYGQCGGMYYTGPTVCASPYTCHVQNQYYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0S7</accession>
    <name>B8M0S7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Choline transporter Hnm1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_086930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_086930"/>
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    <dbReference type="Proteomes" id="UP000001745">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
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        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF20">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
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        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED21460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="509" mass="55391" checksum="46B304E2F67CC04B" modified="2009-03-03" version="1">MADYTTKDAVVEAKGTPEMDADELRLAQMGHTQELKRHFSILSLIGLASTTTISWTGLGLGIVTEIGAGGPGAIIYGFILVTILQSFLGASLAEFVSSYPTEGGMYHWIAAIAPKRYSAFLSFITGWLTVCGWVFTTASTNLIFAQVVQALYALYHPDLVIKTWQTFIIYQILNLLTAAVVLFGNKIIPALNRFSLFYLQIGWLVVLITVVACAPTHQSSEFVFRTWINNTGWNNNVICFITGLVNPLYSLGGLDGVTHITEEMPNPSRNAPLAIAITLTIAFTTGLTYLISLMFSVQDFGALSTTNTGLPLAELFRQATQSAGGAFGLTFILFVALGPCVISSQLSTSRVLWAFARDGAMPFSDTWARVSKRFEIPFNSQLLVAAANAALGCIYLGSSTAFNSMLGAAVTINNVAYLIPIATNMLMGRSGMHKGAFHMGKWGWIVNGVTVAWLLFAIVFFSFPYAMPVTVQNMNYTCVVVGGIPLLVLAWWFLGSKKYKDRIARAKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0S8</accession>
    <name>B8M0S8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_086940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478424.1">
        <property type="nucleotide sequence ID" value="XM_002478379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0S8"/>
    <dbReference type="GeneID" id="8110100"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_086940"/>
    <dbReference type="eggNOG" id="ENOG502RH0W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023528_0_0_1"/>
    <dbReference type="InParanoid" id="B8M0S8"/>
    <dbReference type="OMA" id="TRSTVWY"/>
    <dbReference type="OrthoDB" id="2580323at2759"/>
    <dbReference type="PhylomeDB" id="B8M0S8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40616">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40616:SF1">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002874670" evidence="1">
        <location>
            <begin position="21"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="545" mass="60932" checksum="E2A04D79E1A32DFF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0T7</accession>
    <name>B8M0T7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mannosyl transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_087030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478433.1">
        <property type="nucleotide sequence ID" value="XM_002478388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0T7"/>
    <dbReference type="STRING" id="441959.B8M0T7"/>
    <dbReference type="GeneID" id="8110109"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_087030"/>
    <dbReference type="eggNOG" id="KOG2515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025462_0_2_1"/>
    <dbReference type="InParanoid" id="B8M0T7"/>
    <dbReference type="OMA" id="TMGIRNM"/>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="PhylomeDB" id="B8M0T7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="49347" checksum="73CD5B402532A3C4" modified="2009-03-03" version="1">MSQYISTTSTQVQQFLYQNRGQIHDTVLSITIIASVIWVVYISLQTLRSRYIKTGATATRPSTPDVEKTRRVTRKFGEWTPSSFKRPDPAPYPDWDVKTTRPLPYRPFRYGPKYFVTMGLRNMKWDEWIELDNHYPRYHADKARRIKERGSKCCRTAPEAMDAAIELLEELASYLPARYPSLYRKTGVGIDNLLTGETFNILQRPLPEDPMATCARLVQDDLALMIEKPDGQYYLLAGAILLAGFWRLEDKFGMPLSEIHTSGDVPQYREKLEKGMMNFFRRLKPEDAVLRNNYFLQVDDQLAWSPSIGSEDEPGISWNTAQKNRAIEHHYFRSERQSLRRLPRSGAVVFTIRTYFEPITEIVKEPYVAGRLASAIRSWGDDVSIYKGKEKYAEVLLEFLDKKHEEQLTNGLDLEKEDEVRAYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8M146</accession>
    <name>B8M146_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Benzoate 4-monooxygenase cytochrome P450, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_082210</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477951.1">
        <property type="nucleotide sequence ID" value="XM_002477906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M146"/>
    <dbReference type="STRING" id="441959.B8M146"/>
    <dbReference type="GeneID" id="8107679"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_082210"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_10_1"/>
    <dbReference type="InParanoid" id="B8M146"/>
    <dbReference type="OMA" id="HEHREWR"/>
    <dbReference type="OrthoDB" id="4222002at2759"/>
    <dbReference type="PhylomeDB" id="B8M146"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF112">
        <property type="entry name" value="L-ORNITHINE-N5-MONOOXYGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED20988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="534" mass="61247" checksum="2FD5968A5AA434C1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2V9</accession>
    <name>B8M2V9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Senescence domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_094600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479177.1">
        <property type="nucleotide sequence ID" value="XM_002479132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2V9"/>
    <dbReference type="STRING" id="441959.B8M2V9"/>
    <dbReference type="GeneID" id="8103790"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_094600"/>
    <dbReference type="eggNOG" id="ENOG502S3WR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023639_0_0_1"/>
    <dbReference type="InParanoid" id="B8M2V9"/>
    <dbReference type="OMA" id="WDLGPES"/>
    <dbReference type="OrthoDB" id="20821at2759"/>
    <dbReference type="PhylomeDB" id="B8M2V9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009686">
        <property type="entry name" value="Senescence/spartin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045036">
        <property type="entry name" value="Spartin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068:SF43">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06911">
        <property type="entry name" value="Senescence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Senescence" evidence="2">
        <location>
            <begin position="245"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED22214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="529" mass="56182" checksum="564C7B6279CFC4CB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>B8M386</accession>
    <name>B8M386_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_095040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479221.1">
        <property type="nucleotide sequence ID" value="XM_002479176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M386"/>
    <dbReference type="STRING" id="441959.B8M386"/>
    <dbReference type="GeneID" id="8103834"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_095040"/>
    <dbReference type="eggNOG" id="ENOG502SJ4S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023880_2_0_1"/>
    <dbReference type="InParanoid" id="B8M386"/>
    <dbReference type="OMA" id="WGILILD"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="PhylomeDB" id="B8M386"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED22258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="502" mass="56284" checksum="4FF9A343AFDADC13" modified="2009-03-03" version="1">MTSHALASCFSCRRSKRRCDKSLPSCQLCIRKGLKCNYPHRRGQRSPSPPHSSRGSETATDSDSSTFSSFAVTSAISFLAPDLFRQARLEIPRLRLDIPDDVTSHLGDSQQVRETANNFFQMTWMPIISRKYYLAAVLNPLSPSRRSTALLALCMKLCCLRVEGAERNSLYRLVKKFYSEVESTEGLCVQILQAGIFIAVFEIGDAIYPAAYLTVGACARYGVAMGLDKINKDRMGDAHNFSAPWMEIEERRRAWWAVLILDRFLNVANPCRALATEDPTFEDFLPVDDDQFYDATSQPENAVPISQGFIFKIGHFGRLAQATYLISQVLYTIRSDSAVNDYFNGSGSLSADMGQLCRTLEALVRANEMEITLRRLTFCCQSLVAYSGIFLLQQHLWQRLKVKSTQEAQQHTFIETRIAIDTLCRIASALQERSNMVDLLQGQCTFFLVNIVYQGVSALMTIGQGNPSAEIRESIDTLSYLLGNIRSRWPLAGKVLAKEGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3C6</accession>
    <name>B8M3C6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase, mitochondrial</fullName>
            <ecNumber evidence="6">2.7.7.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">CDP-diacylglycerol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TSTA_095470</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAM41 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479261.1">
        <property type="nucleotide sequence ID" value="XM_002479216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3C6"/>
    <dbReference type="STRING" id="441959.B8M3C6"/>
    <dbReference type="GeneID" id="8105858"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_095470"/>
    <dbReference type="eggNOG" id="KOG2986">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030279_0_0_1"/>
    <dbReference type="InParanoid" id="B8M3C6"/>
    <dbReference type="OMA" id="KQTVNWP"/>
    <dbReference type="OrthoDB" id="341477at2759"/>
    <dbReference type="PhylomeDB" id="B8M3C6"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015222">
        <property type="entry name" value="Tam41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619:SF0">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09139">
        <property type="entry name" value="Tam41_Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="499"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EED22298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="539" mass="61260" checksum="C6C92AA85BBBD890" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3D8</accession>
    <name>B8M3D8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SUN domain protein (Adg3), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_095590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUN family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479273.1">
        <property type="nucleotide sequence ID" value="XM_002479228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3D8"/>
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        <property type="entry name" value="SUN"/>
    </dbReference>
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        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE ADG3-RELATED"/>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
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    <feature type="chain" id="PRO_5002874687" evidence="3">
        <location>
            <begin position="19"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="312"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="416"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED22310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="470" mass="47349" checksum="F2ACABE9F209D048" modified="2009-03-03" version="1">MLSNSLAALVGLLAFADAARTHGHSHQHRSHNHSEVEKRGGQCQFPSNAGLVAVTPGSENGGWAMSPDQPCKPGSWCPYACPPGKVSMQWNPKATSYSYPLSMDGGLYCDENGQIQKPFPDKDYCVDGTGAVTAVNKAGKPLSFCQTVLPGNEAMLIPTLVEDTATLAVPDPSYWCSTAAHYYINPPGTGEEGCIWGTSANPVGNWAYFVAGANTDSSGNTFVKIGYNPVVQEPATPFRNTPASFGVEITCDEGAGCNGLPCKIDPSINALNEVTSGESSDGAGGAAFCVVTVPKGQTANIVVFEAGNSGGSSSSSSSSSSSSSSSSSSSTKASSSSSSSSTSTSTSTSTTPTTTSSPSTTSHSSTTSTSTSSSTSSTPSSTTTHTPSSTEASTTPASSSPKSTSATYSYAPHVFAETSASGDGGATTTSAGDSKPASPSASPSSAASPMSTGSMTGLALCLMAGIMMQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3I6</accession>
    <name>B8M3I6_TALSN</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">TSTA_096070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED22358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002479276.1"/>
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    <dbReference type="GeneID" id="8105918"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_096070"/>
    <dbReference type="eggNOG" id="ENOG502SZ9U">
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="1"/>
            <end position="23"/>
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            <begin position="24"/>
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        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED22358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="153" mass="16966" checksum="1910CFE4E9E5BE34" modified="2009-03-03" version="1">MKTTSNYSNVLPLLAFLWETASADNTLSRYKQPLPPNIQIADTKPKLRELQDANPGALVGPENGGWFLKYPDSGKVVAATSDNLTIDLDQRYMSFYHHLEEEGNHEEAADVLRELQENGADLQKLKADWNCGGSGEGMGLIPKYWADFPAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8M409</accession>
    <name>B8M409_TALSN</name>
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        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
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    </protein>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    <dbReference type="OMA" id="YWATEIY"/>
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    <dbReference type="PhylomeDB" id="B8M409"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42029">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED20752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="41529" checksum="90154EF335093B6B" modified="2009-03-03" version="1">MLIGSTRAILSRIIDHAIHRPSPSPTYRRLCYDWYNMSNTGPASRPTDPDALVLGAWGQGLMVGSLVVMAALTIANMRKGVLLHKLILAELILATLHGTWIFTTFPVYGWFLATTAILLFASWSLHNVIAWMKIRPFLSRRLSVFYIGTVCLVQPFWIVDTYSIFAFYNNVGATEIYLKIRPWEALFRDPWWLCTFCLLLYIINKIYNISFLELIRISPRVGVMLFSMFASLVFILLDILSVTGVMDLGLAAGIEPFWKLSFIFKYLSDIVILDDFKTALDRIRAYRLSQANATRSLRAPNEYSGSGGNRRDTLSEAFDDIESGIELSPMQYPSSAATASSHIEVDNLSQRHLHVQAGSSENPHGISST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8M467</accession>
    <name>B8M467_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Voltage-dependent anion channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_040040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
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                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002481199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M467"/>
    <dbReference type="FunCoup" id="B8M467">
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    </dbReference>
    <dbReference type="GeneID" id="8109763"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_040040"/>
    <dbReference type="HOGENOM" id="CLU_030057_5_1_1"/>
    <dbReference type="InParanoid" id="B8M467"/>
    <dbReference type="OMA" id="RDSAMWA"/>
    <dbReference type="OrthoDB" id="1099at2759"/>
    <dbReference type="PhylomeDB" id="B8M467"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000319">
        <property type="term" value="F:sulfite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051629">
        <property type="entry name" value="Sulfite_efflux_TDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686:SF1">
        <property type="entry name" value="SULFITE EFFLUX PUMP SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED20810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="31418" checksum="774E0255CD82BE76" modified="2009-03-03" version="1">MVSHPIQSLFLGTFPMGFATIINMFCFVCVPTWGQWAAYFALAMWIVDAVISVLACFGIPFIIIVAEVVPNFQIALGTLVTSFVLWGVGVLLSLTVIVIYLMRLMLHKLPPKAVIVSMFLPLGPLGQGGYGIQKLGSVAKTILPQTNTLGAGAGDTFYEMGFVTGLLFWAFGLFWLLCAVGSIAQVRKFPFNLGWWAFTFPLGVYATCTCQLGREMPSKSFAMLGTIFSLSVIFLWILVTAFTISGIHDGTLFVAPCLAVLREKRRREFERERLVNIGDNSPSFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4I3</accession>
    <name>B8M4I3_TALSN</name>
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        <recommendedName>
            <fullName evidence="3">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_025000</name>
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    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ENTH_VHS"/>
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        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF0">
        <property type="entry name" value="U2 SNRNP-ASSOCIATED SURP MOTIF-CONTAINING PROTEIN"/>
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        </location>
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        <location>
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            <end position="1078"/>
        </location>
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        <location>
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            <end position="98"/>
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        <location>
            <begin position="407"/>
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        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
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            <end position="699"/>
        </location>
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        <location>
            <begin position="816"/>
            <end position="829"/>
        </location>
    </feature>
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        <location>
            <begin position="830"/>
            <end position="839"/>
        </location>
    </feature>
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        <location>
            <begin position="916"/>
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        </location>
    </feature>
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        <location>
            <begin position="1051"/>
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    </feature>
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        <location>
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            <end position="1131"/>
        </location>
    </feature>
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        <location>
            <begin position="1180"/>
            <end position="1189"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED19178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1189" mass="130487" checksum="2E859CDF76FA517D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4U9</accession>
    <name>B8M4U9_TALSN</name>
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        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 1A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 4C</fullName>
        </alternativeName>
    </protein>
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        <name evidence="12" type="ORF">TSTA_026890</name>
    </gene>
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        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 9">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the eIF-1A family.</text>
    </comment>
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        <property type="protein sequence ID" value="EED19384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002479773.1"/>
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    </dbReference>
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    <dbReference type="GeneID" id="8098969"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_026890"/>
    <dbReference type="eggNOG" id="KOG3403">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109098_0_1_1"/>
    <dbReference type="InParanoid" id="B8M4U9"/>
    <dbReference type="OMA" id="KMEDQEY"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:translation initiation factor activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Eukaryotic translation initiation factor 1A"/>
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    </dbReference>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NA-bd_OB-fold"/>
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        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
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        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="16"/>
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        </location>
    </feature>
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    </feature>
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            <begin position="127"/>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED19384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="149" mass="17226" checksum="A87F3B975C64B9C0" modified="2009-03-03" version="1">MPKNKGKGGKNRRRGKNENDNEKRELIFKEDGQEYAQVVKMLGNGRLEAQCFDGEKRLAHIRGKLRKKVWINQGDIILLSLRDYQDEKGDVIMKYSADEARSLKAYGELPENAKINETDTYGHEGFEDNVEFDEDRDSSDEKEIDVDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4Y7</accession>
    <name>B8M4Y7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Autophagy-related protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_027190</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Preautophagosomal structure membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <text evidence="7">During pexophagy, accumulates in the vacuolar membrane region, where the peroxisomes contact the vacuole.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATG11 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EED19422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002479811.1"/>
    </dbReference>
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        <property type="interactions" value="140"/>
    </dbReference>
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    <dbReference type="GeneID" id="8109638"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_027190"/>
    <dbReference type="eggNOG" id="ENOG502QUQE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002803_1_0_1"/>
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    <dbReference type="OMA" id="GLRWYLI"/>
    <dbReference type="OrthoDB" id="447953at2759"/>
    <dbReference type="PhylomeDB" id="B8M4Y7"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:phagophore assembly site membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:vacuolar membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:molecular adaptor activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:protein kinase binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:autophagosome assembly"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:autophagy of mitochondrion"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of autophagy of mitochondrion"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:reticulophagy"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040040">
        <property type="entry name" value="ATG11"/>
    </dbReference>
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        <property type="entry name" value="Atg11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATG11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
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        <location>
            <begin position="96"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy-related protein 11 C-terminal" evidence="11">
        <location>
            <begin position="1075"/>
            <end position="1218"/>
        </location>
    </feature>
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        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
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        <location>
            <begin position="573"/>
            <end position="613"/>
        </location>
    </feature>
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            <end position="658"/>
        </location>
    </feature>
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        <location>
            <begin position="1180"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1261"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="536"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="832"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="596"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1261"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1316"/>
            <end position="1326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013804"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
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        <source>
            <dbReference type="RuleBase" id="RU367075"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF10377"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED19422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1367" mass="154208" checksum="28F80E7E42727837" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8M590</accession>
    <name>B8M590_TALSN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_029700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="PhylomeDB" id="B8M590"/>
    <dbReference type="Proteomes" id="UP000001745">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="EED19696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="419" mass="46623" checksum="932D4D5DAF1D58F0" modified="2009-03-03" version="1">MGIATPIQLFNTSWSAHRLSPLHHSKDHRVLIGNQDALKTYAKRLRDVLTGDFLRSMQVTLTKNLADDAFSKAGSLVDCRWEFISTNDHVDANEEDEDDEPSIEMRDCMGIFITLDYENIAYRAALLTSPDGYSPASTDKRWKQSTCLPLLLTRMPTTLRNTFIEFLTTNFDAYCSTLHLPPEYLCMVLEATITYLARSESSWQASSAILEQVLKDTQLTLSFGQSIAPALKSLDVSLPRETLSTFARGPRNANTSYFSTSLSQYMDQHLAMKVNLGNATAEELGNGSRSAQHLWLSKVATGTFVLTSEGRFKLIDTSNSQDYAEEQTEVQRLIRSANGQILRSLVRRAVGDDVTTPRNFRVTTSKGSTGLENSRGCSLAGASRDPHNLTQPGEPQTQLLFAATGNRNVWQAYKTRNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5E0</accession>
    <name>B8M5E0_TALSN</name>
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        <submittedName>
            <fullName evidence="10">Sugar transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_030150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002480135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5E0"/>
    <dbReference type="GeneID" id="8106582"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_030150"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="InParanoid" id="B8M5E0"/>
    <dbReference type="OMA" id="PRWYITR"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="PhylomeDB" id="B8M5E0"/>
    <dbReference type="Proteomes" id="UP000001745">
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    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="15"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED20129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="348" mass="36591" checksum="692D4AA7DDAFD1A2" modified="2009-03-03" version="1">MNMAPNKAAWLQKAGTPLEVGDAPMPIPGPNEIIIQNSAVAINPLDNHMQDAGVFVQQWPTIFGCDVAGTVYEVGSEVQRFKKGDRVIGHAINLVTGKPQDGAFALYTAVPEDKAAILPDAIPFTQGVVVAFAIEAAVCALFVKQAGTAMPGVSTPALGLPYPSLRSVSSNKTLIVYGGSSSVGSTTTQLATAAGIKVISIASERNFDLCKDCGATEVFDYHVPTFVEKVIAAASDPEREFVGIFDAISTQETYANDLVILNRLGGVHLACVHPPPENVPDSIKAGMIFAVNDVATPVWTEYVTPALETGKLKCLPHPTVVGKGLESIDEALHKCKAGVSATKLVVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8M642</accession>
    <name>B8M642_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TBC domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_023760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002479431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M642"/>
    <dbReference type="STRING" id="441959.B8M642"/>
    <dbReference type="GeneID" id="8109558"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_023760"/>
    <dbReference type="eggNOG" id="KOG1102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003663_1_1_1"/>
    <dbReference type="InParanoid" id="B8M642"/>
    <dbReference type="OMA" id="TAWYSFL"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="PhylomeDB" id="B8M642"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000055">
        <property type="entry name" value="TBC domain-containing protein C1778.09"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000023">
        <property type="entry name" value="TBC domain-containing protein C1778.09"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
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        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
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        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
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        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TBC"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="488"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="416"/>
        </location>
    </feature>
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        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
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        <location>
            <begin position="133"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="773" mass="86302" checksum="EEF8A3723B806EEA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B8M650</accession>
    <name>B8M650_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Guanine nucleotide exchange factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_023830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479484.1">
        <property type="nucleotide sequence ID" value="XM_002479439.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B8M650">
        <property type="interactions" value="174"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M650"/>
    <dbReference type="GeneID" id="8109565"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_023830"/>
    <dbReference type="eggNOG" id="KOG3417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001471_0_0_1"/>
    <dbReference type="InParanoid" id="B8M650"/>
    <dbReference type="OMA" id="ICNYATM"/>
    <dbReference type="OrthoDB" id="10254377at2759"/>
    <dbReference type="PhylomeDB" id="B8M650"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF363">
        <property type="entry name" value="PROTEIN SON OF SEVENLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="371"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="1367"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="133"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="581"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="823"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1301"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="582"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="633"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="662"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1301"/>
            <end position="1319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED19050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1614" mass="179004" checksum="D8D3D1871D6D8A40" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8M685</accession>
    <name>B8M685_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_025760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479694.1">
        <property type="nucleotide sequence ID" value="XM_002479649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M685"/>
    <dbReference type="GeneID" id="8107988"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_025760"/>
    <dbReference type="eggNOG" id="ENOG502S5KU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082453_1_0_1"/>
    <dbReference type="InParanoid" id="B8M685"/>
    <dbReference type="OMA" id="AFQQPMT"/>
    <dbReference type="OrthoDB" id="4932428at2759"/>
    <dbReference type="PhylomeDB" id="B8M685"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED19260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="210" mass="24672" checksum="7FAEA7463CB486CE" modified="2009-03-03" version="1">MERRLEMEGMLSNITFIFDYENRRIVHSSYIYLQGARQIVIRQQLQQMERNVQAVVDALSSRRINTLTELRRMERILLTAIQPHVTDLRESSLVGVLATAWLNYVQNHNLLSELRNLTRNYPLSSVMLDEAKSLVMNDPERSHSWNFAWLVLTKIEEEALATNADMWGGILPQEDMITMLEIKCREEWTRAVEIMLRHWDTQPVFPNEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6B1</accession>
    <name>B8M6B1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11 13">3.2.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Glucosidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSTA_026010</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="14">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="11 13"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479720.1">
        <property type="nucleotide sequence ID" value="XM_002479675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6B1"/>
    <dbReference type="FunCoup" id="B8M6B1">
        <property type="interactions" value="605"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M6B1"/>
    <dbReference type="GeneID" id="8108013"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_026010"/>
    <dbReference type="eggNOG" id="KOG2161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007380_1_0_1"/>
    <dbReference type="InParanoid" id="B8M6B1"/>
    <dbReference type="OMA" id="FNWYNTT"/>
    <dbReference type="OrthoDB" id="410058at2759"/>
    <dbReference type="PhylomeDB" id="B8M6B1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070880">
        <property type="term" value="P:fungal-type cell wall beta-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000027">
        <property type="entry name" value="Probable mannosyl-oligosaccharide glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.110:FF:000003">
        <property type="entry name" value="Probable mannosyl-oligosaccharide glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13 19" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 13 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877336" description="Mannosyl-oligosaccharide glucosidase" evidence="16">
        <location>
            <begin position="22"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="18">
        <location>
            <begin position="39"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="17">
        <location>
            <begin position="307"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EED19286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="818" mass="92884" checksum="467ADBBF305E4ED1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6S2</accession>
    <name>B8M6S2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal specific transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_033840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480576.1">
        <property type="nucleotide sequence ID" value="XM_002480531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6S2"/>
    <dbReference type="STRING" id="441959.B8M6S2"/>
    <dbReference type="GeneID" id="8097801"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_033840"/>
    <dbReference type="eggNOG" id="ENOG502QZJZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011099_0_0_1"/>
    <dbReference type="InParanoid" id="B8M6S2"/>
    <dbReference type="OMA" id="VDDNKWM"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="PhylomeDB" id="B8M6S2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="633"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="160"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="711"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="162"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="726"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="759"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED20142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="879" mass="98905" checksum="89FD4B19B9ABD65B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7E6</accession>
    <name>B8M7E6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_035920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non-catalytic component of the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480800.1">
        <property type="nucleotide sequence ID" value="XM_002480755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7E6"/>
    <dbReference type="FunCoup" id="B8M7E6">
        <property type="interactions" value="1187"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M7E6"/>
    <dbReference type="MEROPS" id="T01.A13"/>
    <dbReference type="GeneID" id="8101863"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_035920"/>
    <dbReference type="eggNOG" id="KOG0185">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072435_0_1_1"/>
    <dbReference type="InParanoid" id="B8M7E6"/>
    <dbReference type="OMA" id="QPIMRRY"/>
    <dbReference type="OrthoDB" id="10248542at2759"/>
    <dbReference type="PhylomeDB" id="B8M7E6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03760">
        <property type="entry name" value="proteasome_beta_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000014">
        <property type="entry name" value="Proteasome subunit beta type-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016295">
        <property type="entry name" value="Proteasome_beta4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001213">
        <property type="entry name" value="Psome_endopept_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED20366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="260" mass="28723" checksum="46F28238F856DC8A" modified="2009-03-03" version="1">MDHFPGTWGRPRDDIYGPYDHSYLQSSGPKTHTQSPAVTGTSVIAVKFNGGVAMATDNLASYGSLARFTDVNRIRTFDDAAIVGFGGDVSDMQYIDRLLGSIQIRENYTATGSTLNAKNLHTYLAKVFYKRRSEMNPLWNHILVAGFDSDGSPFLSSADLLGTTFSGPHLATGFGAHLAVPILRRLFPEDTPIENISKEQAIQALRDCMRVLFYRDARSLDQYTLAVITKDGVEVKNKEKLESQSWAFAEAIRGYGTQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7U1</accession>
    <name>B8M7U1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secretory lipase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_030830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480254.1">
        <property type="nucleotide sequence ID" value="XM_002480209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7U1"/>
    <dbReference type="ESTHER" id="talsn-b8m7u1">
        <property type="family name" value="Fungal-Bact_LIP"/>
    </dbReference>
    <dbReference type="GeneID" id="8101762"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_030830"/>
    <dbReference type="eggNOG" id="ENOG502S2P7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029538_2_0_1"/>
    <dbReference type="InParanoid" id="B8M7U1"/>
    <dbReference type="OMA" id="SAWAAEM"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="PhylomeDB" id="B8M7U1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF5">
        <property type="entry name" value="LIP-DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="302" mass="31572" checksum="5A56CA6DF3618ADB" modified="2009-03-03" version="1">MPQLELVFITAALDKGWVVTVPDHLGTKSAFLANHLSAQATLDNVRAALASTEFTSISKDATVTLWGYSGGSLASGFAAELQPTYAPELNIAGVALGGTVPQILPVVYAVNKGIQGLANEYPTAAQLVADNVLPSKAAEFNKTKSLCLSGDTTTYFGQDMFSYVKDPNIFTEPTATALLGANAMGQHLPKIPLYIYKSAGDEISPVNDTDALVAQYYCSGGASVQCKRDELSEHAAMAILGAPDAFMWLEDRMNGRPVELGCSQSTVLTSLTDPDALAALGAGLVDVLLSLLSAPVGPIMIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8M873</accession>
    <name>B8M873_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Efflux pump antibiotic resistance protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_032880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <end position="75"/>
        </location>
    </feature>
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            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
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        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="413"/>
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    </feature>
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        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
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            <begin position="451"/>
            <end position="475"/>
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        <location>
            <begin position="534"/>
            <end position="557"/>
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            <begin position="62"/>
            <end position="570"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED20035.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="570" mass="60977" checksum="F498BB259413781D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
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            <dbReference type="PubMed" id="25676766"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
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    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
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        <property type="entry name" value="Beta Polymerase, domain 2"/>
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        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL"/>
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    </dbReference>
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        <property type="entry name" value="PolyA_pol"/>
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        </location>
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            <begin position="1"/>
            <end position="21"/>
        </location>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED20462.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="581" mass="65538" checksum="2921A11B0BE2A832" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8N8</accession>
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        <submittedName>
            <fullName evidence="1">HAD superfamily hydrolase, putative</fullName>
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        <name evidence="1" type="ORF">TSTA_037690</name>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
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            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED20551.1"/>
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        <property type="nucleotide sequence ID" value="XM_002480940.1"/>
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        <property type="interactions" value="196"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M8N8"/>
    <dbReference type="GeneID" id="8102145"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_037690"/>
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    <dbReference type="HOGENOM" id="CLU_045011_13_0_1"/>
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    <dbReference type="OMA" id="YTWKERS"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="PhylomeDB" id="B8M8N8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
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    </dbReference>
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        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
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        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
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    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
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        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF42">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE-RELATED"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED20551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="278" mass="30837" checksum="0650D1E875846E30" modified="2009-03-03" version="1">MTTHRTDFPAIRACIFDMDGLLINSEDIITVSTNELFKKYGRPVFDSSIRSQLMGVPDSTNGDVFHNWAKLPISREQFARESTENMRRHFPSCKPLPGAQELLSNLSRAHNACSGDRIELALASSTKTRSYKLKTSNPETKGLISFFQADRQVLGDDPRVRQGRGKPAPDIYLVALQCLNSTVSSGNPPIMPNECLVFEDSVAGVEAGRRAGMRVIWVPHPDVAIEHQARQKDVLAGRTGIFNVGDGWQPGDIDDGWAESISSLEQFDYEKYGIKRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8X1</accession>
    <name>B8M8X1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_038400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481068.1">
        <property type="nucleotide sequence ID" value="XM_002481023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8X1"/>
    <dbReference type="GeneID" id="8107882"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_038400"/>
    <dbReference type="eggNOG" id="KOG3105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_14_1_1"/>
    <dbReference type="InParanoid" id="B8M8X1"/>
    <dbReference type="OrthoDB" id="4230268at2759"/>
    <dbReference type="PhylomeDB" id="B8M8X1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="54"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED20634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="472" mass="55053" checksum="5BB789E2AEAB7C01" modified="2009-03-03" version="1">MPSEKYKEEENRISEALEMLRKNPKQKIKPLARQFGVDYQRLRRRVLGGTSQLNRRPAHKRLTEDQERAIILWMHDLDDRGIPPTVRMIKNYVDKVLQNMHPGADNPPQLGDRWVYRFLKRLPKEYVKMKQKTIDPSDILLRTRALYRPERYKITPSNIWNFDESGFQIGQGGDEEVVTRYPDALRHVPSSSSRELVSTAEGISAVGNTIPPLLIFTGKVILESWFQYLKEDEWKVTISETGFSNDEIAYDWLKHFNEHTREQAGNNFRLLFMDNHEAHLTSEFLSYCDDYRIIPFAFPWLPFLQYERVHRRAINEKAHLGGYFYDKIDFLADIARVRADALTLRVIRNGFSARGLWPFNPEIIVGPLIEKWDLQEGQELLIYDNEEPDISSSPTNASFSPPTTAYKLQRSITKVDAQLNEISNVIPGIRRSLKKIFDGSLTQAHIKDQQQAQIERLQTLNERKSAQKKIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8M973</accession>
    <name>B8M973_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_112040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481360.1">
        <property type="nucleotide sequence ID" value="XM_002481315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M973"/>
    <dbReference type="STRING" id="441959.B8M973"/>
    <dbReference type="GeneID" id="8098859"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_112040"/>
    <dbReference type="eggNOG" id="ENOG502RVUF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1085938_0_0_1"/>
    <dbReference type="InParanoid" id="B8M973"/>
    <dbReference type="OMA" id="YTPVEPK"/>
    <dbReference type="OrthoDB" id="5215637at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="146"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="146"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED17368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="284" mass="29185" checksum="E9760980D8D7A623" modified="2009-03-03" version="1">MSKYQCAWPSGIAYIPASSPCGPINKTNSVVPCCANGDFCLSDNICAYTSHSNAGGSGYYSAGCSDGTFLDGQVSSSACANRCADTGLPDIVYDSSDGSWKCCGGNENQRNCQSPTNETFIGAAPSNLFTIWVAGSATTVVSTSMSTSTASTSSSTSSSTSSSTSTSTSPEPTVTTSAATTPAEQAITPTPTAETQPPPSGNSSGLSVGAKAGIAIGAVVLAFALLALISVYIHHRRRRKRPVEHPGMPPTETKGRLPSSLYELPPTPKAQELPPNPKPLPELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9G9</accession>
    <name>B8M9G9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_115280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481721.1">
        <property type="nucleotide sequence ID" value="XM_002481676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9G9"/>
    <dbReference type="GeneID" id="8101338"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_115280"/>
    <dbReference type="eggNOG" id="ENOG502T4VU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062646_0_0_1"/>
    <dbReference type="InParanoid" id="B8M9G9"/>
    <dbReference type="OMA" id="LEPHICR"/>
    <dbReference type="OrthoDB" id="546861at2759"/>
    <dbReference type="PhylomeDB" id="B8M9G9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED17729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="387" mass="44639" checksum="D0EE46AEF3DA2A8C" modified="2009-03-03" version="1">MLTAPSSGNSSHESITATIMSIDRPVIFGGVPDVLFLILSMGDASTIPTLCRLNKATYETIKSHETFLCTSFLRLHDFNPPLDRILTMDPITGQRNPLNFVNLQKFVFRRQTALKLASRVARSGFGAWWAIKGAGEMDAEAEMFRQRVERGLYVMFHMSDIARDVERVKLRPHRAAGNTYRIMLLSWLPCMRCEKSGINRNWWFPRHISHIYVVLLRKSQQREIGKLRWRFRQMLDLERRVDFHIALQMLRQFLETIIFAHCPDDDASISSLSGEDVDVTNWFLLRQGAHSLARIFLELPDRDCCSIEDRARKQKDGVLPVCDYSEALKEYWDARNGDSTVDCKKCEAWLRSSSTQSILNDFFGLHALDLGKEWVRQMRGEGELFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9J2</accession>
    <name>B8M9J2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_117690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481986.1">
        <property type="nucleotide sequence ID" value="XM_002481941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9J2"/>
    <dbReference type="STRING" id="441959.B8M9J2"/>
    <dbReference type="GeneID" id="8105827"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_117690"/>
    <dbReference type="eggNOG" id="ENOG502S7WN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030520_1_0_1"/>
    <dbReference type="InParanoid" id="B8M9J2"/>
    <dbReference type="OMA" id="DERTMTM"/>
    <dbReference type="OrthoDB" id="5385072at2759"/>
    <dbReference type="PhylomeDB" id="B8M9J2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="365" mass="39797" checksum="376ADDAADA5DA423" modified="2009-03-03" version="1">MAARVQMQQGNNPTDYRMYQVPSRRPVGATHHAGLQFQQPPETPSPQQRVAPNFDHLQSHSRTRTTSSTVLPYVGNSQHIRHQHQQHHIFHRQPHQRAQPASTAGPVPTRSSSSATTSTSSTSGNHQRLTHTMSTMSSSDIHRSSSSRSTTAPLSYVALMRRQKGTVWCDRAQPEDPRLQAQKRAAKQRAGKAAPGYSPSTLVGAIVPPRLSANEIGDDEEDDRSSEGAPYHRRTGSARSSLGSMHRYPSGYQRPQGKTPPNEQANIPEVVENSASAAHPDKAQIPQDTINTNSSSSSQMDLPTEDHEGENDFGSLGEMGAPAAANITMNKAKKADDLRRRGSVDDRTTSLTGVRLFVANPDADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9S2</accession>
    <name>B8M9S2_TALSN</name>
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        <submittedName>
            <fullName evidence="8">MFS allantoate transporter, putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">TSTA_118430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482066.1">
        <property type="nucleotide sequence ID" value="XM_002482021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9S2"/>
    <dbReference type="GeneID" id="8099767"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_118430"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="InParanoid" id="B8M9S2"/>
    <dbReference type="OMA" id="GANIFMW"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="PhylomeDB" id="B8M9S2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000361">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.2, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF26">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09470)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="80"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED18074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="529" mass="59355" checksum="8EAF2E34662C67C7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MA16</accession>
    <name>B8MA16_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-dependent oxidoreductase-like enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_120890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482337.1">
        <property type="nucleotide sequence ID" value="XM_002482292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MA16"/>
    <dbReference type="STRING" id="441959.B8MA16"/>
    <dbReference type="GeneID" id="8100073"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_120890"/>
    <dbReference type="eggNOG" id="ENOG502SFGG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018105_0_0_1"/>
    <dbReference type="InParanoid" id="B8MA16"/>
    <dbReference type="OMA" id="HGHTRGA"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="PhylomeDB" id="B8MA16"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="144"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED18345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="53616" checksum="DFD5EF61D85B8AD0" modified="2009-03-03" version="1">MSQDSEVRSQASLAPAAEILIPNLKPVRDHNGSLSDKNGGVSSSSEMTPPPSSQTRAPLRRRSRSGSNVVIPASPPKESLEKSLYAAYGAAENLPTIEDIDAADDAQVRKIAKDLLAIAQEARMSALHFKLQNSLLSFTSNEAIKRAEVEQQLARREVEILQSSEYQNRRANSYSRTPQICPTPDSEASLKRVAELERTNARLEERLSNAKILIQEKIDEGNSKNESLLEENRLLKKRIRDNREHLTMFLDAGSLSPNSRPEFSTPQRKSQPRVFDSARTHASSRGSSHDAFATLLAADRVLHGDSTNVSPTRNRHRNGHLGGAHVRGAHSMSSLPVTPQRHTHVHGFQYTTPVSRTHTTVRKDTSDPENNRHDRDSTISVSDAEEVITDEDIPASQASSRATDMLRRLPEINQETNSPQGPSANRSNIGKSSTLLQTKIFGQVKKAGVDRSGPASQKRKGSFVEEGPVLKKPKEVGLGISSWKISPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAJ3</accession>
    <name>B8MAJ3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_112510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481409.1">
        <property type="nucleotide sequence ID" value="XM_002481364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAJ3"/>
    <dbReference type="STRING" id="441959.B8MAJ3"/>
    <dbReference type="GeneID" id="8105716"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_112510"/>
    <dbReference type="eggNOG" id="ENOG502RUBN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019364_0_0_1"/>
    <dbReference type="InParanoid" id="B8MAJ3"/>
    <dbReference type="OMA" id="SEGCPHD"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="PhylomeDB" id="B8MAJ3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="140"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED17417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="390" mass="43618" checksum="59756ACB966AFCAC" modified="2009-03-03" version="1">MTDNWDPAKPLVARQPLKFVYILYYILTSAVSVPTWAILYGIPFLRPVSSWSYKTALVNKISYHLLKFLSMIRIQTPQPITPGNETDLFVVLEPAKDLKKTYTGLLDNPQIQPTTVGAFWIPNLKHLASATSSTNSNWIILHFHGGAYVLLTPRDPAVQRGPRQLCEELPADAALCLDYRLSSKPKSSYPAQLQDALTAYNYLIHDQQISPSRILVSGDSAGAHLAITFLRHLTTHPESGLPLPRALLLHSPWLDLTEKKLSVDNIQKGRDYVSDAFVQWGATTFTPAGSPRDAEFVSPFYHPFTSPIPIWVQAGGVETLYATIVEWVNKMRNAGSAIELYTMEDMPHDVFHLSTGMGLETEARKALRAAKAFLIKDSIQVIYFTQLSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MB71</accession>
    <name>B8MB71_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_125720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482852.1">
        <property type="nucleotide sequence ID" value="XM_002482807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MB71"/>
    <dbReference type="STRING" id="441959.B8MB71"/>
    <dbReference type="GeneID" id="8098084"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_125720"/>
    <dbReference type="eggNOG" id="ENOG502RF7U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024934_5_2_1"/>
    <dbReference type="InParanoid" id="B8MB71"/>
    <dbReference type="OMA" id="KADHETM"/>
    <dbReference type="OrthoDB" id="4937900at2759"/>
    <dbReference type="PhylomeDB" id="B8MB71"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED18860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="412" mass="46847" checksum="59FE0959FCE39DE9" modified="2009-03-03" version="1">MSRRRFHTKSRYGCLQCKHSRKKCDENRPQCGRCEKAGQHCSLSDISSSLMFISTDPTAERFKKILNVVERQPNSEMAISSTVFHGRSTNTSPADTSSCPSFTSTSENVSETHISDTEKERLRLMHHYTLHTAKTLAELSIPTDRDQTIWSDFAVDLALEHDLVLHGLLSLSALHLALRGIFKQRHTILAIHHHDLGLAIFRTHLTNITSHNYDSIFAFTCIVMLYAFGIQRCSESTANTIAKVHQILTLISNSRPITKSHMDALRHSRWSVMMMSEPYPTLDQKLPDDMEAMLAKLAQRVAVTAKTASQADVYNAVVQSLRYILILTSTPRPAQVTLVIFPMLSPREYWDMMRDHDPLALAVLANYAVTLHWLRYSIWLEGWGKETVDAVHATLPPEWHDCINWAVEQTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8MB74</accession>
    <name>B8MB74_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Low molecular weight phosphotyrosine protein phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_125750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482855.1">
        <property type="nucleotide sequence ID" value="XM_002482810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MB74"/>
    <dbReference type="FunCoup" id="B8MB74">
        <property type="interactions" value="578"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MB74"/>
    <dbReference type="GeneID" id="8098087"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_125750"/>
    <dbReference type="eggNOG" id="KOG3217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071415_2_0_1"/>
    <dbReference type="InParanoid" id="B8MB74"/>
    <dbReference type="OMA" id="YQQVTRF"/>
    <dbReference type="OrthoDB" id="3388at2759"/>
    <dbReference type="PhylomeDB" id="B8MB74"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004726">
        <property type="term" value="F:non-membrane spanning protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16343">
        <property type="entry name" value="LMWPTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050438">
        <property type="entry name" value="LMW_PTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002115">
        <property type="entry name" value="Tyr_Pase_low_mol_wt_mml"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717:SF7">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00720">
        <property type="entry name" value="MAMMALPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="Phosphotyrosine protein phosphatases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphotyrosine protein phosphatase I" evidence="7">
        <location>
            <begin position="10"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR617867-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED18863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="197" mass="22069" checksum="9120D35F653BB2D6" modified="2009-03-03" version="1">MANERTPAPVSVLFVCLGNICRSTMAEGVFHSLCSSSQQYGALIDEIDSAGTGAYHTGDSPDYRTMATLKQHNITNYNHAARKVNKDDFRRFDYILAMDEYNLKDLLRLRDNIISQSARTKAHTNTISTECTTPKIAEVRLFGDFNPDGTVNKKVGGGQEIEDPYYGGINGFEIAYEQAMKFSKGFLVYLERKQQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8MB76</accession>
    <name>B8MB76_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_125770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482857.1">
        <property type="nucleotide sequence ID" value="XM_002482812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MB76"/>
    <dbReference type="GeneID" id="8098089"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_125770"/>
    <dbReference type="HOGENOM" id="CLU_071653_0_0_1"/>
    <dbReference type="InParanoid" id="B8MB76"/>
    <dbReference type="OMA" id="RADIQID"/>
    <dbReference type="OrthoDB" id="4224843at2759"/>
    <dbReference type="PhylomeDB" id="B8MB76"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="310" mass="35968" checksum="49E4FC0F1920FE29" modified="2009-03-03" version="1">MTASRASETAWRVNNWPVLAKIDTRLNFDKEDHCEFMYYKRHDMSNTRFENGTDLRKYVRDEIITTAVWKMDSKAQRIGNDGALTLVEAMEERMARMEKELADQKKKTAEQAEELADQKKRTVDQAEELADQKKRTADQVKELADQKKKVAGRNRLWWKFRVSELERIIKKTHNAARFERNEIVHGADVLNDYQALEYADRPDNEAQFKTASEGFKKAYGLQLGSFSYDKLSKAPEGVIDIISLRGNVTFLDWFSNHKEEAGVIAKQCDLAVRKWLKSIKTNGVPYPEDAVKADYKRVKELYDSVRSQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBA7</accession>
    <name>B8MBA7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zinc finger C2H2 LYAR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_126070</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UPF0743 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482888.1">
        <property type="nucleotide sequence ID" value="XM_002482843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBA7"/>
    <dbReference type="STRING" id="441959.B8MBA7"/>
    <dbReference type="GeneID" id="8098119"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_126070"/>
    <dbReference type="eggNOG" id="KOG2186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024874_0_0_1"/>
    <dbReference type="InParanoid" id="B8MBA7"/>
    <dbReference type="OMA" id="CMVHFYG"/>
    <dbReference type="OrthoDB" id="21474at2759"/>
    <dbReference type="PhylomeDB" id="B8MBA7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.490:FF:000001">
        <property type="entry name" value="cell growth-regulating nucleolar protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039999">
        <property type="entry name" value="LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014898">
        <property type="entry name" value="Znf_C2H2_LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100:SF10">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08790">
        <property type="entry name" value="zf-LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51804">
        <property type="entry name" value="ZF_C2HC_LYAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger C2H2 LYAR-type" evidence="10">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="62"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="236"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="330"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="391"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="539"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="391"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED18896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="593" mass="66237" checksum="6DC8C8718C6C7D87" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MC65</accession>
    <name>B8MC65_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Purine-cytosine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_122440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482503.1">
        <property type="nucleotide sequence ID" value="XM_002482458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MC65"/>
    <dbReference type="FunCoup" id="B8MC65">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MC65"/>
    <dbReference type="GeneID" id="8097709"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_122440"/>
    <dbReference type="eggNOG" id="ENOG502QQ8Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026016_2_2_1"/>
    <dbReference type="InParanoid" id="B8MC65"/>
    <dbReference type="OMA" id="LWLSANM"/>
    <dbReference type="OrthoDB" id="2116389at2759"/>
    <dbReference type="PhylomeDB" id="B8MC65"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11484">
        <property type="entry name" value="SLC-NCS1sbd_CobB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF1">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED18511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="514" mass="56094" checksum="2CD56C375B11AE51" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8MC71</accession>
    <name>B8MC71_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Folic acid synthesis protein FOL1</fullName>
            <ecNumber evidence="10">2.5.1.15</ecNumber>
            <ecNumber evidence="12">2.7.6.3</ecNumber>
            <ecNumber evidence="11">4.1.2.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Folic acid synthesis protein fol1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">TSTA_122500</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes three sequential steps of tetrahydrofolate biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19949"/>
            <dbReference type="ChEBI" id="CHEBI:17836"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="EC" id="2.5.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the DHPS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the DHNA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="22">In the central section; belongs to the HPPK family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="10"/>
    <dbReference type="EC" id="2.7.6.3" evidence="12"/>
    <dbReference type="EC" id="4.1.2.25" evidence="11"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482509.1">
        <property type="nucleotide sequence ID" value="XM_002482464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MC71"/>
    <dbReference type="FunCoup" id="B8MC71">
        <property type="interactions" value="246"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MC71"/>
    <dbReference type="GeneID" id="8097715"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_122500"/>
    <dbReference type="eggNOG" id="KOG2544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8MC71"/>
    <dbReference type="OrthoDB" id="615426at2759"/>
    <dbReference type="PhylomeDB" id="B8MC71"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.20:FF:000006">
        <property type="entry name" value="Dihydropteroate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.560:FF:000005">
        <property type="entry name" value="Folic acid synthesis protein fol1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="entry name" value="7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="entry name" value="Dihydropteroate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="FOLATE SYNTHESIS PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941:SF1">
        <property type="entry name" value="FOLIC ACID SYNTHESIS PROTEIN FOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="Dihydropteroate synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="16" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 27" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="26">
        <location>
            <begin position="280"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00012458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00013043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00058009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00061548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00067568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00068111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="EED18517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="557" mass="60933" checksum="C0D1EE07DB072506" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8MC73</accession>
    <name>B8MC73_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ARF GTPase activator (Glo3), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_122510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482511.1">
        <property type="nucleotide sequence ID" value="XM_002482466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MC73"/>
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    </dbReference>
    <dbReference type="STRING" id="441959.B8MC73"/>
    <dbReference type="GeneID" id="8097716"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_122510"/>
    <dbReference type="eggNOG" id="KOG0706">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023062_7_0_1"/>
    <dbReference type="InParanoid" id="B8MC73"/>
    <dbReference type="OMA" id="PANQVCF"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="PhylomeDB" id="B8MC73"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000013">
        <property type="entry name" value="Putative Arf GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="9"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="120"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="275"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="357"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED18519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="484" mass="51801" checksum="502664CC85F5245F" modified="2009-03-03" version="1">MSATKAQSQKIFEKLKTKPANRLCFDCGSKNPTWSSVPFGIYLCLDCSSHHRNLGVHISFVRSTNLDQWQWEQLRIMKVGGNESATKFFQSHGGSAALASKDPHVKYESPAAVKYKEELKRRAAQDAKEHPGEVVVTDVAGTPGDDTATPAGEPDDDFFSSWDKPVIKRPSNPPSRVGTPSNASRTASPFLNAGSNGNGARSKSPLSASDKDETSSPPPTAVRTGNVVRKGPTGAGAKKGSILSSKKTPKLGAKKVVSSDAIDFEEAERKAKEEAERIEKLGYDPEAEQAELEAKEKATATTKIASPTPISPARGGFGSTGKAPEKSASEMERLGMGMSRLGFGQVSKPAVAKKPGFGAVAPAQRSAADEEEIEQNRTRFGSQKGISSDEFFGRDRFDPAAQAEAKTRLNNFEGATSISSNAYFGRPEEDYPAIDDGYGDLENAAKDFVRRFGITAGDDLENLTQVLGEGATKLQGAIRSYLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCF1</accession>
    <name>B8MCF1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NmrA-like family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_124860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482759.1">
        <property type="nucleotide sequence ID" value="XM_002482714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCF1"/>
    <dbReference type="STRING" id="441959.B8MCF1"/>
    <dbReference type="GeneID" id="8100265"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_124860"/>
    <dbReference type="eggNOG" id="ENOG502S5T1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_10_4_1"/>
    <dbReference type="InParanoid" id="B8MCF1"/>
    <dbReference type="OMA" id="NGWYHEN"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="PhylomeDB" id="B8MCF1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05269">
        <property type="entry name" value="TMR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052718">
        <property type="entry name" value="NmrA-type_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47129:SF1">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47129">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="322" mass="36184" checksum="8CEC1E93C485CB55" modified="2009-03-03" version="1">MTLKYLITGATGGLGSQVLKHLSNHLPSSDYAAASSNEASRAQFEKAGITFRLANFDDPATLEAAFADVENLYFVSTNTFDNARRTVQHRNVIEAAKRVGVRHVWYTSLAFGGLGSDSKMSVQQAHLETEKMLKEAGITYTSIREGIYADAFPLFLQWYPTIETIILPSDGVITYTSRDELGEANAKLLLKGGHENEIILLTANEPLTGGEIIKIINETTGRNVKLQLVSPEEYIKYHTENDIGKKPESFWQQRISWFEGIAKGDADLKNPLMREVLGREPKTGSQLIRELLTENRDYTWHQNYIDKAQYEATLKKEHRNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCX8</accession>
    <name>B8MCX8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-arabinitol dehydrogenase ArbD, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_113300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481496.1">
        <property type="nucleotide sequence ID" value="XM_002481451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCX8"/>
    <dbReference type="STRING" id="441959.B8MCX8"/>
    <dbReference type="GeneID" id="8101642"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_113300"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="InParanoid" id="B8MCX8"/>
    <dbReference type="OMA" id="GYRICIN"/>
    <dbReference type="OrthoDB" id="5307821at2759"/>
    <dbReference type="PhylomeDB" id="B8MCX8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF14">
        <property type="entry name" value="DEHYDROGENASE ARBD, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED17504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="356" mass="38004" checksum="B17E3B14F606263E" modified="2009-03-03" version="1">MATIFKPAARQAVRAVARSSIRPSLTINTNIRSLSTTPARFQDDEKKGAAAPPGAFARTDDSLVIEHPADEEMPRSPVVQGRGGMHFKRTLASFSLENRVSVVTGGARGLGLVMGQALVASGSDLAIVDLNKDEAQEQAEKLVAQFSKENPGLEELPKVTAHYADVSDPDSVNAVLANIIGQHGKIDNLVTSAGFTENFDAISYPYDRMKKLWGVNVDGTYLFATGVAKHLMERKAPGSIVMIGSMSGAIVNVPQPQAPYNAAKAAVRHLAASLAVEWAGANIRVNCISPGYMLTALTKKILDENPELNRKWTSLIPQGKMGTPEDLMGAVTFLLSDASRYVTGADLRVDGGYTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8MD85</accession>
    <name>B8MD85_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_114230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481602.1">
        <property type="nucleotide sequence ID" value="XM_002481557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MD85"/>
    <dbReference type="STRING" id="441959.B8MD85"/>
    <dbReference type="GeneID" id="8109185"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_114230"/>
    <dbReference type="eggNOG" id="KOG0126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045495_2_0_1"/>
    <dbReference type="InParanoid" id="B8MD85"/>
    <dbReference type="OMA" id="GSWHVDY"/>
    <dbReference type="OrthoDB" id="2573941at2759"/>
    <dbReference type="PhylomeDB" id="B8MD85"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12411">
        <property type="entry name" value="RRM_ist3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051847">
        <property type="entry name" value="RNA_proc/Spliceosome_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045844">
        <property type="entry name" value="RRM_Ist3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF1">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="33"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="113"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="201"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED17610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="285" mass="34013" checksum="C09CB4A466A88424" modified="2009-03-03" version="1">MNSIRQIQALNKRELENAVPPEASWHADYRDTAYIYIGGLPFDLSEGDIVTIFSQYGEPVHVNLVRDKDTGKSKGFAFLKYEDQRSTDLAVDNLGGATVMGRVLRVDHTRYKRKDGEEEEDNVATIMGSTTGHRDEDTDTERRDRKSWRKGGDTDENDVEEPSRPMLKEEIELVELMRDHDDEDPMKEYLIQEKKEEVARALENLKSREKKSSSRRKDSRERSHKHRHHHHHHHHRRRRSDERSRERSHRELDDGSRRERHRRERSESPHRRQERSRERSRRERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDD2</accession>
    <name>B8MDD2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_116840</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481887.1">
        <property type="nucleotide sequence ID" value="XM_002481842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MDD2"/>
    <dbReference type="FunCoup" id="B8MDD2">
        <property type="interactions" value="749"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MDD2"/>
    <dbReference type="GeneID" id="8102076"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_116840"/>
    <dbReference type="eggNOG" id="KOG3327">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049131_3_1_1"/>
    <dbReference type="InParanoid" id="B8MDD2"/>
    <dbReference type="OMA" id="YWHQFDA"/>
    <dbReference type="OrthoDB" id="425602at2759"/>
    <dbReference type="PhylomeDB" id="B8MDD2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01672">
        <property type="entry name" value="TMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000679">
        <property type="entry name" value="Thymidylate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="10">
        <location>
            <begin position="18"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED17895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="238" mass="26517" checksum="A6C968A90F3018CC" modified="2009-03-03" version="1">MAELSASDKEKRGALVVVEGLDRAGKSSQCELLYKSLLGMNYKAKYIRFPDRSTPIGKQIDSYLRGQSQLDDHSIHLLFSANRWELAQSIHEYIANGTTVIVDRYSYSGAVYSAAKGNPNLSLHWAWQPEVGLPRPDLCLFLSISPEEAAKRGGYGVERYETDSMQKRVRELFLSLLDLPHNDEICVIDAGQSVDEVAQDILDPVLECMKNVDSIGPLKKLGPWTFIPTGESPTGRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8ME80</accession>
    <name>B8ME80_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_015910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483741.1">
        <property type="nucleotide sequence ID" value="XM_002483696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ME80"/>
    <dbReference type="STRING" id="441959.B8ME80"/>
    <dbReference type="GeneID" id="8106364"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_015910"/>
    <dbReference type="eggNOG" id="ENOG502SFBR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_453545_0_0_1"/>
    <dbReference type="InParanoid" id="B8ME80"/>
    <dbReference type="OMA" id="GHENTYL"/>
    <dbReference type="OrthoDB" id="4226666at2759"/>
    <dbReference type="PhylomeDB" id="B8ME80"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="617" mass="70906" checksum="22277AEFA41E3A74" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEK6</accession>
    <name>B8MEK6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_017080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483867.1">
        <property type="nucleotide sequence ID" value="XM_002483822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEK6"/>
    <dbReference type="STRING" id="441959.B8MEK6"/>
    <dbReference type="GeneID" id="8103681"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_017080"/>
    <dbReference type="eggNOG" id="ENOG502SMV5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042688_2_0_1"/>
    <dbReference type="InParanoid" id="B8MEK6"/>
    <dbReference type="OMA" id="DMAMTDG"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="PhylomeDB" id="B8MEK6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="33236" checksum="622DC63312AD2202" modified="2009-03-03" version="1">MATETITVQAVINANINYFLEVSEGGTDVIYPGTATDKLRPLKSVIMPITDLRTCKDENFTLDTHGFQFVPHKTKEKTYDDQERIKTVVYDETAALLREVTGATRVVPFSHLIRKHLVDTAVEAAKKAAPTDIIPIMTPSLLCHIDQSYDGAKQVLEDNLPPAVAESLSKTRWGIINVWRPVGGPVKRDPLAVCDARSCAESDLRKVFAQLPSQGDGSTVSVGAGFEVFNVAHNPNHKWYYALTMTPDETLMIKCFDSKTDGRARRTPHTAFQTDRDEGPARQSIEVRCLVFWENDSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFI4</accession>
    <name>B8MFI4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_017920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483952.1">
        <property type="nucleotide sequence ID" value="XM_002483907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFI4"/>
    <dbReference type="FunCoup" id="B8MFI4">
        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MFI4"/>
    <dbReference type="ESTHER" id="talsn-b8mfi4">
        <property type="family name" value="CGI-58_ABHD5_ABHD4"/>
    </dbReference>
    <dbReference type="GeneID" id="8109992"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_017920"/>
    <dbReference type="eggNOG" id="KOG4409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017361_3_0_1"/>
    <dbReference type="InParanoid" id="B8MFI4"/>
    <dbReference type="OMA" id="ADQHLVM"/>
    <dbReference type="OrthoDB" id="7457040at2759"/>
    <dbReference type="PhylomeDB" id="B8MFI4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042171">
        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF29">
        <property type="entry name" value="PUMMELIG, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="156"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED16718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="509" mass="56647" checksum="A28C949DA50325C4" modified="2009-03-03" version="1">MPSVETVSQAHGGMGNEGLQDTRESGRKLPHSVTHGMAPASSSWLPLGMKETLHQWWHKAPAAVAEHKVLSTIPYLQEAPTQLQTGSTASAPNSPTATDSLQAVDPSQSGDEIVNSNNDPYGPRRWRSRMVELSGKNRALNEFSVERIGEEADQNLVMLHGYGAGLGFFYRNFEPLSRAKGWHLYALDLLGMGRSTRPPFKIKASDREEAITEAENWFIDALEEWRVKRKIDRFTLMGHSMGGYIAAAYALKYPGRLNKLILVSPVGIPEDPYAVNEAMPTDSTEGNGTNNRMPPRLPRLITYLWDANVSPFSFIRWSGPLGPGLVSRWTSRRFSHLPYAEAAALHDYTYSIFRLRGSGEYALTYLLAPGAFARSPLIRRIQGIGRQVIRPDSPVAMTSVSDVSAASVAASPASQPLRENGIPVIFMYGDHDWMDVAGGFSAKEKIEEERRRILKEATPEQREADNGSAKVYIVKNAGHHLYLEGDEEFNDIILKEMEDVRRREAKRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8MG14</accession>
    <name>B8MG14_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_009990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483115.1">
        <property type="nucleotide sequence ID" value="XM_002483070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MG14"/>
    <dbReference type="STRING" id="441959.B8MG14"/>
    <dbReference type="GeneID" id="8102795"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_009990"/>
    <dbReference type="eggNOG" id="ENOG502SK5D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063253_0_0_1"/>
    <dbReference type="InParanoid" id="B8MG14"/>
    <dbReference type="OrthoDB" id="4899673at2759"/>
    <dbReference type="PhylomeDB" id="B8MG14"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002875081" evidence="2">
        <location>
            <begin position="23"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED15881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="320" mass="35246" checksum="DEF2A2C0BC7FBC59" modified="2009-03-03" version="1">MRFTVSQAFLVSLLASSQFVLGFQSDVEAREVDKKHVGSPSTFASRWVQLSAPVEARHHTESQIAAKEAAAKKKGKKPKREASPQEADEFGPWDSTEDEFGSWVDKRDPHHTEAQIAAKEAAAKKKGKKPKREASPEAADEDDSEVEKREAHHTEAQIAAKKAAAGKKNGKKPKREASPQEPDEFGPWDSTEDEFGSWVDKRDPHHTEAQIAAKKAAAAKKNGKNPKREASPEETEEESEIEKREAHHTEAQIAAKKAAAGKKNGKKPRREASPQEADEFGPWDSTEDEFGSWVDKREAHHTEAQIAAKKAAAKKKGTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGZ9</accession>
    <name>B8MGZ9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphogluconate dehydrogenase NAD-binding putative C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_014720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483614.1">
        <property type="nucleotide sequence ID" value="XM_002483569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGZ9"/>
    <dbReference type="STRING" id="441959.B8MGZ9"/>
    <dbReference type="GeneID" id="8107855"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_014720"/>
    <dbReference type="eggNOG" id="ENOG502S5V0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052530_0_1_1"/>
    <dbReference type="InParanoid" id="B8MGZ9"/>
    <dbReference type="OMA" id="YAGINKG"/>
    <dbReference type="OrthoDB" id="9988102at2759"/>
    <dbReference type="PhylomeDB" id="B8MGZ9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015814">
        <property type="entry name" value="Pgluconate_DH_NAD-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09130">
        <property type="entry name" value="DUF1932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphogluconate dehydrogenase NAD-binding putative C-terminal" evidence="2">
        <location>
            <begin position="219"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED16380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="35239" checksum="9675DD8110AC7458" modified="2009-03-03" version="1">MTVTVGILSIGDMGVGIARLLNANSYRVVTVGTGRSQDTLDRIQAASIEALPTDQDLVIQSDYILSIVPPRDSLATARRILEALNLPDTLSKRKAQQHGASEKVYFFDLNASSPRLMREIDDLFSMPSATGETIVQFIDGGIIGGPPSYDEIDQKWKKPSIVLSGPVDDLPSSFHTLLQSTLNMTLVGTKIGSASALKLSFASLTKGLTALSLLSFTTAQTEGVLAHLLQHLEDYSPKTGALAAAGVVGMSPKAYRWVEEMRSIGEAFDTEGHWGSLGGNVFDSFAEVYRRVAEETVLGQEKIGRRERGRSVEDVADILAQANAAIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHS0</accession>
    <name>B8MHS0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_014910</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483634.1">
        <property type="nucleotide sequence ID" value="XM_002483589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHS0"/>
    <dbReference type="STRING" id="441959.B8MHS0"/>
    <dbReference type="GeneID" id="8106233"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_014910"/>
    <dbReference type="eggNOG" id="ENOG502QUI0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006123_1_0_1"/>
    <dbReference type="InParanoid" id="B8MHS0"/>
    <dbReference type="OMA" id="CHDHSIF"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="PhylomeDB" id="B8MHS0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051439">
        <property type="entry name" value="XlnR/Xlr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663:SF2">
        <property type="entry name" value="ARABINOLYTIC TRANSCRIPTIONAL ACTIVATOR ARAR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="672"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="688"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED16400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="896" mass="100203" checksum="CA78D8DABEAAE405" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MI78</accession>
    <name>B8MI78_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Monoxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_040420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484515.1">
        <property type="nucleotide sequence ID" value="XM_002484470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MI78"/>
    <dbReference type="STRING" id="441959.B8MI78"/>
    <dbReference type="GeneID" id="8109999"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_040420"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_6_3_1"/>
    <dbReference type="InParanoid" id="B8MI78"/>
    <dbReference type="OMA" id="NAREYMI"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="PhylomeDB" id="B8MI78"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000153">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF5">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="141"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED14562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="435" mass="48372" checksum="5DF7AC36A7F0346A" modified="2009-03-03" version="1">MDSGNASQKQFTVAIVGGGIGGLTLAIGLLRHNVLVKIYEAASAFGEIGLGLSIGPAAHRAMPLIDPQIRDIYDSLITTHADSPGYEKFRQTWFEVIWATGEKSGQRLMTLNALPSDQTTVRRSDFLNALVNLIPPGVAQFGKRLVKLEENTACVTLSFEDGTTVVADVVVGCDGIRSKVKESLFPDDLERVQPRYSGMYGYRAVFDMETLVEAVGDERARVSTWYIGKGAYAITYPIMRAKKVNVGLCTLNDTWNSDEWVRKASKKDMQRDFEHMGEYVNSIMKYMSDASQWAIFEHPHIPTFAKSKVAILGDAAHASTPHQGAGACQAIEDAHVLAELLADTRVTSPELVAIAFKAYNAVRWERSQKVVTSNKENADLLCLCYEGIGDDGQKLQDTWQERFRWLWDIDIEEQAEKARSIMLDLMHHQHLLPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIB1</accession>
    <name>B8MIB1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_040750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484548.1">
        <property type="nucleotide sequence ID" value="XM_002484503.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484549.1">
        <property type="nucleotide sequence ID" value="XM_002484504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIB1"/>
    <dbReference type="GeneID" id="8110032"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_040750"/>
    <dbReference type="eggNOG" id="ENOG502RNXH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196187_0_0_1"/>
    <dbReference type="InParanoid" id="B8MIB1"/>
    <dbReference type="OMA" id="GERQPKE"/>
    <dbReference type="OrthoDB" id="4221763at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="82" mass="9463" checksum="02F72E9164A6FD11" modified="2009-03-03" version="1">MSSAIASQAGQILREMFKIPSRAREQAGTTWRSLRQTEKPKKELLQTSLMIHRPIWITGVAGTYTTAYACYLTMKYLRKLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJ16</accession>
    <name>B8MJ16_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7702 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_051160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485631.1">
        <property type="nucleotide sequence ID" value="XM_002485586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJ16"/>
    <dbReference type="GeneID" id="8106318"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_051160"/>
    <dbReference type="eggNOG" id="ENOG502SN6X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064985_3_1_1"/>
    <dbReference type="InParanoid" id="B8MJ16"/>
    <dbReference type="OMA" id="VYWSHRW"/>
    <dbReference type="OrthoDB" id="2560628at2759"/>
    <dbReference type="PhylomeDB" id="B8MJ16"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G00100)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="19"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED15678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="213" mass="22654" checksum="06E6897ACB8A6B4E" modified="2009-03-03" version="1">MVLHCHLLYNPLIAAGLKYKSDQDHNLSSGALIVDNIGLSPLLLGAAGILHEARYARHAIRNHKVEWLVVLQYHMLVSAGLALIAVSISNLVKPDSSGSGLGLLKGGFAVLFISWVILFLATVFSMQRPASFNQLANDESFRNGALLLNAALLSLPMTLLRAVYGAINLFGSGKSVDTAAFSSNIPADVCMSLIPPMLATFAFVGVGLITPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJ33</accession>
    <name>B8MJ33_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_051310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485648.1">
        <property type="nucleotide sequence ID" value="XM_002485603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJ33"/>
    <dbReference type="STRING" id="441959.B8MJ33"/>
    <dbReference type="GeneID" id="8106333"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_051310"/>
    <dbReference type="eggNOG" id="ENOG502SPRN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036934_2_0_1"/>
    <dbReference type="InParanoid" id="B8MJ33"/>
    <dbReference type="OMA" id="AQSEMGH"/>
    <dbReference type="OrthoDB" id="2590011at2759"/>
    <dbReference type="PhylomeDB" id="B8MJ33"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="15"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED15695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="35424" checksum="7678A37D887F546F" modified="2009-03-03" version="1">MKKTLTFISGHWSAKDNDSEHISSSRSQSAYSKRREQVRKAQRSRVYSSHRERKAHYHSTLESEVLRLRTNEASFLKKISDLEAQLYSLQEVIKINGIELPTVEKYGRHATELDTNAALMLPIVGDPNVENTVHDIPAPRQRSKNANSTTDITQTLSSPSPKLGQPAEAGSAMDKTLLAHGMEFVLTLEKPCLGHINVDLNNSSEPSGHVLTASMPLLSTHHYPHSFNDGSPSLEASRTIFERLTTLSSELVHDEEFSPIQLWNYIMDQPLAYKLDITQLRVLAESLVHHVRCYGFGAVLEKEVCVKMVARILTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJA0</accession>
    <name>B8MJA0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_041670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484642.1">
        <property type="nucleotide sequence ID" value="XM_002484597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJA0"/>
    <dbReference type="STRING" id="441959.B8MJA0"/>
    <dbReference type="GeneID" id="8102944"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_041670"/>
    <dbReference type="eggNOG" id="ENOG502QWIX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_7_1_1"/>
    <dbReference type="InParanoid" id="B8MJA0"/>
    <dbReference type="OMA" id="LGRMENN"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="PhylomeDB" id="B8MJA0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="39237" checksum="A840F1BB9EEA3650" modified="2009-03-03" version="1">MATASRDASHDPADSSERTPDHAFIEASEIDTDASESAYGDETESYTTSLKSSIRNYRYENGRRYHAFRDEAYFLPNDEIESDRLDLFHEILTRRCDGELYLAPLGPDPQRILDLGTGTGIWAIDMGDKFPSASVLGNDLSPIQPTIVPPNVRFEVDDIENDWVYGSKFDFIHGRYLAGAVKDWPRLMRQAFKFTKPGGWVEFQDFDMRFYTVKGEFTPGCPLDEWTKIVINGLKKVGVEPEPGPKLEGWVKEAGFTNVHHKLLPIPVGVWPKDKKLKEIGALDYHQFLEGLEGISMHIFTASEGWKPEEVQLFLMGLRKDLKNPRLQAQHNFHVVYAQKPLDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJK5</accession>
    <name>B8MJK5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_046590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485158.1">
        <property type="nucleotide sequence ID" value="XM_002485113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJK5"/>
    <dbReference type="GeneID" id="8099570"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_046590"/>
    <dbReference type="eggNOG" id="ENOG502RNQC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024594_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJK5"/>
    <dbReference type="OMA" id="AEYCEQC"/>
    <dbReference type="OrthoDB" id="4526763at2759"/>
    <dbReference type="PhylomeDB" id="B8MJK5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="521" mass="58932" checksum="69584E56F3C4CE87" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJQ0</accession>
    <name>B8MJQ0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_051860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485702.1">
        <property type="nucleotide sequence ID" value="XM_002485657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJQ0"/>
    <dbReference type="STRING" id="441959.B8MJQ0"/>
    <dbReference type="GeneID" id="8103407"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_051860"/>
    <dbReference type="HOGENOM" id="CLU_1620183_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJQ0"/>
    <dbReference type="PhylomeDB" id="B8MJQ0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="185" mass="21597" checksum="199077BD396C0D0B" modified="2009-03-03" version="1">MAPNTNPNEFDPEGKNRTQRDTYVEGKLKKYKEAEDVVLWAIFKQDFEKWSLNHLWQTSFLLLSKLITLLKSNGMYVDDTKGYLITENVATAAAQREPHEWTKTEVIAHLRKGSGDSFKRKLKIFYGYCRQNGLPNTPKSYREALPHMLRDAALSYYWDNINLWIVQGKDPAEEIITRFKGPEHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJQ8</accession>
    <name>B8MJQ8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_051940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485710.1">
        <property type="nucleotide sequence ID" value="XM_002485665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJQ8"/>
    <dbReference type="STRING" id="441959.B8MJQ8"/>
    <dbReference type="GeneID" id="8103415"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_051940"/>
    <dbReference type="HOGENOM" id="CLU_1138644_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJQ8"/>
    <dbReference type="OrthoDB" id="4368687at2759"/>
    <dbReference type="PhylomeDB" id="B8MJQ8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="135"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="269" mass="30961" checksum="B91736DC3DB03011" modified="2009-03-03" version="1" fragment="single">ANCWKSRDKVQMHLFSESKVQNYDILAIQEPYINKHTDPLTTYSLALKGSFHILLQPTPKEEYKKRPQVCFYINRGLDPATWEVQYHNRDLSTLTLHTATHGTIHIHNVYNPGVNSNEESIISALQTAMAPRAQHIATKLINLMDEHGLKQLLPLGTITYERVNTKSTIDLVWASHNLANRVVSCDTKPEWWYGADHVSISTQFNLTAICVPPLIHKQWNVTDWDLFLKLMDIYNWYPRELNDNEAINEAIRYLVEAINQAAEQATPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKQ5</accession>
    <name>B8MKQ5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_043750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484857.1">
        <property type="nucleotide sequence ID" value="XM_002484812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKQ5"/>
    <dbReference type="STRING" id="441959.B8MKQ5"/>
    <dbReference type="GeneID" id="8097883"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_043750"/>
    <dbReference type="eggNOG" id="ENOG502RIYQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1327163_0_0_1"/>
    <dbReference type="InParanoid" id="B8MKQ5"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="PhylomeDB" id="B8MKQ5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="207" mass="22970" checksum="3126BB2A4DEB000E" modified="2009-03-03" version="1">MALDRYQTDKILTLECEGEKFSILKSIVRKHSPVMSKAPTTEVIPVIEFNASTLRCMLDFMYEGKYDVKESGSTEGPRSRNIMLILNEAEVRSVDALREAELDNKLAADYYDVPELKQQSNDNILNILENSWSADDIAAAAELAVASTSDTALYAIITTAVADHITELIDREDFIQHTLLAGISIGIIQDLPKKLAASDAKAKTYQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8ML39</accession>
    <name>B8ML39_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_048950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485408.1">
        <property type="nucleotide sequence ID" value="XM_002485363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ML39"/>
    <dbReference type="STRING" id="441959.B8ML39"/>
    <dbReference type="GeneID" id="8100611"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_048950"/>
    <dbReference type="eggNOG" id="ENOG502SR1P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_0_0_1"/>
    <dbReference type="InParanoid" id="B8ML39"/>
    <dbReference type="OMA" id="YRRIFRG"/>
    <dbReference type="OrthoDB" id="5393606at2759"/>
    <dbReference type="PhylomeDB" id="B8ML39"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF157">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="31"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED15455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="371" mass="40702" checksum="35A56A7A293D2335" modified="2009-03-03" version="1">MTAIQDIRIHAPVVIAEAVCLIVFCSLMVGLRFYARRVKNSRLGLDDLAISLALLFVIGMAVTILVETGIKGFGYAASEGDAGPNHPDANVAGWPTELLQVPALGCIKLSFLLFYRRVFTKYVAWEFTWVNYFMIASVIAWTICFFFLLLFLCGTDFAAYWTSGETEAKYCLPTGPVHMGYAISDVIMDFLTILLPIGEIWKLHLPTRRKFAIMCVFGLGAITIAMSIVRMVIYQRALAVQFDPDSDEEYLTTLTTYFSMLEAGLGVIAACLPVQYGLLKSEKVQSIIHSVHSLTSLGSRGSSNNSRGISLTQSRAQSQRIHDIDGSQVSEVGLSLPANAAVTAGSDIDMDHFDGQGIVVHKSFGTNEQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLF1</accession>
    <name>B8MLF1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Xylosidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_049230</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485437.1">
        <property type="nucleotide sequence ID" value="XM_002485392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLF1"/>
    <dbReference type="STRING" id="441959.B8MLF1"/>
    <dbReference type="GeneID" id="8100639"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_049230"/>
    <dbReference type="eggNOG" id="ENOG502SHWK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009397_11_2_1"/>
    <dbReference type="InParanoid" id="B8MLF1"/>
    <dbReference type="OMA" id="FNFNWWQ"/>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="PhylomeDB" id="B8MLF1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04084">
        <property type="entry name" value="CBM6_xylanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18618">
        <property type="entry name" value="GH43_Xsa43E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CBM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052176">
        <property type="entry name" value="Glycosyl_Hydrlase_43_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772:SF2">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CBM6" evidence="9">
        <location>
            <begin position="366"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="7">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED15484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="492" mass="53839" checksum="7A694442DF21A7FE" modified="2009-03-03" version="1">MACIKEVNRTWVTNSAMLSPLLRPHPDRTDNMKQIKPTPLLRHLRSSFLLLGVLLNDIGIGIAKADNPFVQSMYTADPAPLIYNDRLYVFMDHDENGATTYEMKDWRLFSTTDMANWQDHGSPMSLANFSWANANAWAPQIIARNNQFYFYAPVRHSTGSMAIGVGVSDTITGPYHDALGKPLVENNEIDPTVFVDDDGQAYLYWGNPDLWYVKLNQDMISYSGSPIQIPLTTAGFGTRSNNAQRPTTFEEAPWVYKRNGIYYIAYAADCCSEDIRYSTGTGPTGPWTYRGVIMPTQGGSFTNHEGIIDYKNNSYFFYHNAALPGGSGYQRSVCVERFVYNSDGTIPTIQMTTAGPPQLGTLNPYVRQEAETAAWSSGIQTEVCSEGGIDVAFINNGDYIKVKGVAFGASPGAHSFSARVASGASGGSIQIHLGSTSGTLVGSCSVPGTGGWQTWTTVTCSVSGAVGTQDVYFVFQGSGSGYLFNFDYWQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8MM47</accession>
    <name>B8MM47_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_098160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485797.1">
        <property type="nucleotide sequence ID" value="XM_002485752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MM47"/>
    <dbReference type="STRING" id="441959.B8MM47"/>
    <dbReference type="GeneID" id="8108455"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_098160"/>
    <dbReference type="eggNOG" id="ENOG502SN2U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092535_1_1_1"/>
    <dbReference type="InParanoid" id="B8MM47"/>
    <dbReference type="OMA" id="CTLWFAF"/>
    <dbReference type="OrthoDB" id="1523883at2759"/>
    <dbReference type="PhylomeDB" id="B8MM47"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="177" mass="19749" checksum="9A4A7E449A6E0965" modified="2009-03-03" version="1">MASRLVFDPMAALAVAPLVSSTCTLWYALDQHHFLRVFTSPTNRPKSDFILPTYFKEFFSAGLPRVIGLLGLTFWTSIGNYYWRYDSLVASHSLRWYIAGAALSASHLLFVPLVAPRIRAIVEDDPSKGPPTSVLDEWLNIHFLRTWTVDLAAWACLAVAVASNPHTLVSMGLQLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMA9</accession>
    <name>B8MMA9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Gibberellin 20-oxidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_099160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485901.1">
        <property type="nucleotide sequence ID" value="XM_002485856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMA9"/>
    <dbReference type="STRING" id="441959.B8MMA9"/>
    <dbReference type="GeneID" id="8103994"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_099160"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_6_3_1"/>
    <dbReference type="InParanoid" id="B8MMA9"/>
    <dbReference type="OMA" id="KMKTWVE"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="PhylomeDB" id="B8MMA9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF881">
        <property type="entry name" value="FI07970P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="182"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED13663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="357" mass="39357" checksum="B6861554B0837F0E" modified="2009-03-03" version="1">MSTTFSSLPIVDLAPLRKPEGLSDSDQVTLSTKLYNVFATTGFAYLVNTPLTFKHADVFDLALEFFNLPLEKKMNLAKRTFKPENLNTYRGYFPVQPNDASDNLKEGFEIGPPQAIHSMPANPASRFNLTEPNVWPDENTYPSRSRLEQLYIELQSLSSTILSLLASSLDKPADFFTPYLTDSLSTLRLLHYPPSPSNTTDTPIDIDTSTPPPEPSDPVKLSCTPHTDSGILTLLHQDSTGGLEVQDSSGKWVPAPYVPESVVVNIGDLMAKVSGGRFVATMHRVRAPPPSPFSMKQHGLHSEDEDGDAKFGRFSAPFFFEPGENCLVHSVDTDPSKGVLYGNHVLTKMEGFVEYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNJ0</accession>
    <name>B8MNJ0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">hydroxymethylglutaryl-CoA lyase</fullName>
            <ecNumber evidence="3">4.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_103060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:24404"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="4.1.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="3"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486317.1">
        <property type="nucleotide sequence ID" value="XM_002486272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNJ0"/>
    <dbReference type="STRING" id="441959.B8MNJ0"/>
    <dbReference type="GeneID" id="8102925"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_103060"/>
    <dbReference type="eggNOG" id="KOG1680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022138_4_1_1"/>
    <dbReference type="InParanoid" id="B8MNJ0"/>
    <dbReference type="OMA" id="KEFQAGR"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="PhylomeDB" id="B8MNJ0"/>
    <dbReference type="UniPathway" id="UPA00896">
        <property type="reaction ID" value="UER00863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004419">
        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046951">
        <property type="term" value="P:ketone body biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07938">
        <property type="entry name" value="DRE_TIM_HMGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000071">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004283">
        <property type="entry name" value="PRK05692.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738:SF17">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="7">
        <location>
            <begin position="8"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED14079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="563" mass="61836" checksum="13053DEB11FA54AD" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNT7</accession>
    <name>B8MNT7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_103950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486414.1">
        <property type="nucleotide sequence ID" value="XM_002486369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNT7"/>
    <dbReference type="STRING" id="441959.B8MNT7"/>
    <dbReference type="GeneID" id="8103167"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_103950"/>
    <dbReference type="HOGENOM" id="CLU_098703_0_0_1"/>
    <dbReference type="InParanoid" id="B8MNT7"/>
    <dbReference type="OMA" id="PLETWTI"/>
    <dbReference type="OrthoDB" id="4509690at2759"/>
    <dbReference type="PhylomeDB" id="B8MNT7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED14176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="20391" checksum="C798198D31BDE9BE" modified="2009-03-03" version="1" fragment="single">PSHRSASERGAMIVLQHNCACTGAVVHTALEAALQAGAGMACLQEPPVRGKYQISHPGFLLYWPEGPREHARVVTAIRRDLVRDLVVEARTDLANHPYFMVVDVLEQGRRTRIVNCYDNWLGARHTYLGESLLTRRALSDLDWGPILEGRCLVLGDFNAHSPMWNTPIDQRVNARSLEDLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNY9</accession>
    <name>B8MNY9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_104440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486466.1">
        <property type="nucleotide sequence ID" value="XM_002486421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNY9"/>
    <dbReference type="STRING" id="441959.B8MNY9"/>
    <dbReference type="GeneID" id="8103215"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_104440"/>
    <dbReference type="eggNOG" id="ENOG502SJ9D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013260_0_0_1"/>
    <dbReference type="InParanoid" id="B8MNY9"/>
    <dbReference type="OMA" id="QEWTYSI"/>
    <dbReference type="OrthoDB" id="3014581at2759"/>
    <dbReference type="PhylomeDB" id="B8MNY9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF90">
        <property type="entry name" value="CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED14228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="708" mass="79879" checksum="8A445FB690E16BDE" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8MP34</accession>
    <name>B8MP34_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative transcription factor kapC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_104870</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative transcription factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bZIP family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486511.1">
        <property type="nucleotide sequence ID" value="XM_002486466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MP34"/>
    <dbReference type="STRING" id="441959.B8MP34"/>
    <dbReference type="GeneID" id="8098708"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_104870"/>
    <dbReference type="eggNOG" id="ENOG502SC5V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050914_0_0_1"/>
    <dbReference type="InParanoid" id="B8MP34"/>
    <dbReference type="OMA" id="PHMQPNT"/>
    <dbReference type="OrthoDB" id="2593073at2759"/>
    <dbReference type="PhylomeDB" id="B8MP34"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="10">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="84"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="172"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="265"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED14273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="325" mass="35690" checksum="20EBFF0527E8B8FE" modified="2009-03-03" version="1">MQPALAPHPSMQQSSSAQDHADQVLHDQLLAAQQHLQSQGQESRAPTGQQGHNIDPAISGGAMLAPNTQASSLVLPQVMSGVQEAASGNDASRKTYGKRELSTSKRAEQNRAAQRAFRQRKEGYIRQLESQVKDYKVLSESYKALQAENYQLREYIISLQSRLIDSQNEVPALPDNIDLTQPRPEPPLADSHQSESSPPAQPQPQSQQTQQQQQRQHTLAAAPTQVPPLAPHQHPHQPSTAPSSNTNEDIGQLNRIAVAGLGMRKHGLSSSQTDSNNNNNNNNNNNNRDGGYPSYPWKRPRGDDYADTRNSEVKIESIHGLPTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPC3</accession>
    <name>B8MPC3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Benzoate 4-monooxygenase cytochrome P450, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_105730</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486600.1">
        <property type="nucleotide sequence ID" value="XM_002486555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPC3"/>
    <dbReference type="STRING" id="441959.B8MPC3"/>
    <dbReference type="GeneID" id="8100432"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_105730"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_4_1"/>
    <dbReference type="InParanoid" id="B8MPC3"/>
    <dbReference type="OMA" id="IRTVFHE"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="PhylomeDB" id="B8MPC3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED14362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="507" mass="57668" checksum="0824F305B4727B10" modified="2009-03-03" version="1">MSSFEGGLRVIEWGIASFILYSLFTGVYRLFLSPISHIPGPKLAALTYFYEFYYDAICKGRYLWKIQELHQQYGPIVRINPREVHINDVDFYDQIYASGPQHPRNKLRFMATHDESMFDTYDADMHRYRRAAMSVSFSKSSIRALEPVIRRTVEQLCSRIRALVGTGAVVNMKELYSGLTMDVIGQYCFGESMDNLKQEQFGKAFLDFFHQMPQGHPIGRMFPWLFDVLQKIPIGILAKIDPGLQPLADYDKKISSQINSVLQKSKHDNIRTVFHEMRDSKHLPPDEKTLERFKAEAAIFLGAGTETTASALTTISYYLLENPGMLLRLRAELGSGIPNGSNEPLTLARLEPLPYLSAVIQEGIRLSFGVPGRLPRYSPKETLIYNGYTLPAATVMSESSYLIHTNKELYPDPFAFRPERWLDGKISASNFVPFSRGARMCIGINLAYAELYLTLAAVFTSFDFELIGTTKRDVEIRHDFFVGMPALESQGVRVKVLQERRINDGHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPK8</accession>
    <name>B8MPK8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pantothenate transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_106570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486685.1">
        <property type="nucleotide sequence ID" value="XM_002486640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPK8"/>
    <dbReference type="GeneID" id="8103557"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_106570"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_4_2_1"/>
    <dbReference type="InParanoid" id="B8MPK8"/>
    <dbReference type="OMA" id="YSWMADL"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="PhylomeDB" id="B8MPK8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015233">
        <property type="term" value="F:pantothenate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098717">
        <property type="term" value="P:pantothenate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000386">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF4">
        <property type="entry name" value="PANTOTHENATE TRANSPORTER FEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="30"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED14447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="483" mass="53839" checksum="70A6A1C0C0008D26" modified="2009-03-03" version="1">MSFLNSKIAHWLWGDDIKDRHLLGRLDITLLPYFSLIWFLFGVTRASYSSAYVSGMHEALHFQGKDYNYMNTAYLVVYAVCQMPGTSLLTIARPKYVFVAANVVWSVLTLITYKTTSAWQVILLNAIEGGFSAIAYVGAQFVLGSWYKKNELGTRAAVFCVFGQLGSMAGGWIQAGLLESLSGKSGLPAWKWIFIIVSVMTIPVALFGWVFIPDLPIHRAAWYLTAEQKEHAISRLGASRKESWDLTVFKRIFLSWQFYLLPFLFMLYSLCVQMLQNNVMALWMAARGYTVIQQNNYPTGIYATAILGTVIYAVISDKIKSRWEVSVAIGLTFIIGSAILVGTGVDSDVAHFFAFYLLGTTFAPQAVWYSWMADLTSHDVQLRAITTGFMNSFDFAFVTWWPLIFYPVTDAPDYHKGYIASLVTGTLTLPLIAIVTYLEKRDTARGLIGRVSEATNNSSGQDGEPNAGFKDGSVNVRSAEVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPM2</accession>
    <name>B8MPM2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_106710</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486699.1">
        <property type="nucleotide sequence ID" value="XM_002486654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPM2"/>
    <dbReference type="STRING" id="441959.B8MPM2"/>
    <dbReference type="GeneID" id="8103571"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_106710"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_6_1"/>
    <dbReference type="InParanoid" id="B8MPM2"/>
    <dbReference type="OMA" id="AMPIVYN"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="PhylomeDB" id="B8MPM2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF158">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="55"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED14461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="531" mass="58348" checksum="0DDB83B0B7AA0C44" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQW8</accession>
    <name>B8MQW8_TALSN</name>
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        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_053210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="nucleotide sequence ID" value="XM_002486869.1"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_053210"/>
    <dbReference type="eggNOG" id="ENOG502SSGF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079951_2_0_1"/>
    <dbReference type="InParanoid" id="B8MQW8"/>
    <dbReference type="OMA" id="RFCYLIN"/>
    <dbReference type="OrthoDB" id="4074965at2759"/>
    <dbReference type="PhylomeDB" id="B8MQW8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G08640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G08640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="6"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED12803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="160" mass="17729" checksum="2B36BD963190D5C5" modified="2009-03-03" version="1">MDIIPRSLLITIRLGQFAFSAIVAGMIGYFISLFDLNDAGFLLGRWIYVEILAGLSVILGLIFLLPAFLLFFIWPIDVVIALAWFAAFGLLFDALDGLVCGGVDGLGPVNDGGNCTVWETAEAFSFLSAFTWLITGFLGLYLVWRADEHGKRQWHQTYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSJ3</accession>
    <name>B8MSJ3_TALSN</name>
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        <recommendedName>
            <fullName evidence="4">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_001440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487727.1">
        <property type="nucleotide sequence ID" value="XM_002487682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSJ3"/>
    <dbReference type="STRING" id="441959.B8MSJ3"/>
    <dbReference type="GeneID" id="8098638"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_001440"/>
    <dbReference type="HOGENOM" id="CLU_1595658_0_0_1"/>
    <dbReference type="InParanoid" id="B8MSJ3"/>
    <dbReference type="PhylomeDB" id="B8MSJ3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="19075" checksum="4BA6B7BE29FF3BA2" modified="2009-03-03" version="1">MPLQKDPLAEKALLIKAPREDKHGKISPLNLDDILDDIKNNKGDFQEVTKKVQNAVEAGIWKIDKFTKKMDLNIIYYIAAVLNLQVKISFIRAQMSKSDVDVIVSDIHEYIKKQYSASPTSSSSAERPPDSSPEMWSHSMIEDGDPDWILKWWKVNAFNYPLMLKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTU3</accession>
    <name>B8MTU3_TALSN</name>
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        <recommendedName>
            <fullName evidence="5">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_005230</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002488095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTU3"/>
    <dbReference type="STRING" id="441959.B8MTU3"/>
    <dbReference type="GeneID" id="8104507"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_005230"/>
    <dbReference type="eggNOG" id="KOG2031">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007773_2_0_1"/>
    <dbReference type="InParanoid" id="B8MTU3"/>
    <dbReference type="OMA" id="FPPMDGQ"/>
    <dbReference type="OrthoDB" id="47785at2759"/>
    <dbReference type="PhylomeDB" id="B8MTU3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09122">
        <property type="entry name" value="PLDc_Tdp1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09123">
        <property type="entry name" value="PLDc_Tdp1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF4">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="5">
        <location>
            <begin position="553"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="14"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="625"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="632"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="558"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="560"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="3">
        <location>
            <position position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED12486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="673" mass="75193" checksum="34B1D052ED42F035" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTW9</accession>
    <name>B8MTW9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Membrane bound cation transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_006130</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488237.1">
        <property type="nucleotide sequence ID" value="XM_002488192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTW9"/>
    <dbReference type="STRING" id="441959.B8MTW9"/>
    <dbReference type="GeneID" id="8105298"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_006130"/>
    <dbReference type="eggNOG" id="KOG1397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008721_3_1_1"/>
    <dbReference type="InParanoid" id="B8MTW9"/>
    <dbReference type="OMA" id="HSYIYES"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="PhylomeDB" id="B8MTW9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000016">
        <property type="entry name" value="Membrane bound cation transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000011">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF18">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="601"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="667"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="700"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="728"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="151"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="603"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="23"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="333"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="526"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="357"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="379"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED12583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="766" mass="82072" checksum="4A4F7AE07FB5258B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8MU18</accession>
    <name>B8MU18_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">D-xylulose reductase</fullName>
            <ecNumber evidence="13">1.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Xylitol dehydrogenase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSTA_006700</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="12">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.9" evidence="13"/>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488305.1">
        <property type="nucleotide sequence ID" value="XM_002488260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MU18"/>
    <dbReference type="STRING" id="441959.B8MU18"/>
    <dbReference type="GeneID" id="8105355"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_006700"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_963713_0_0_1"/>
    <dbReference type="InParanoid" id="B8MU18"/>
    <dbReference type="OrthoDB" id="250802at2759"/>
    <dbReference type="PhylomeDB" id="B8MU18"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016471">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046526">
        <property type="term" value="F:D-xylulose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2950:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01147">
        <property type="entry name" value="V_ATP_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0859">Xylose metabolism</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="17">
        <location>
            <begin position="144"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EED12651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="289" mass="32161" checksum="1EAF50F0E407F437" modified="2009-03-03" version="1">MMAGSQPLIALQSAQNSAGIQTLLDAEREAQKIVQQDRTKRVKEARSEAQREIDEYRKQKEEEFKKFEAEHSSGNKKAEEEANKEAEAQLAEIKVAGQKSGDKVIKDLINAVTDVKPDTCLHVYFIVNQQSLVRDVQTDNHQVHYWEHSSIDSFVVREPMVLGHESSGVVSKVGSKVTTLKVSDQVAMEPGIPCRRREPYKSGKYHLCINMAFAATPPYDGTLTRYYRLPEDFCYKLRENIPLKKGALIEPLGVAVHVVKQAGVVPGNSVVVFGAGPVGLCTKYVPRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUG5</accession>
    <name>B8MUG5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_110170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488593.1">
        <property type="nucleotide sequence ID" value="XM_002488548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUG5"/>
    <dbReference type="STRING" id="441959.B8MUG5"/>
    <dbReference type="GeneID" id="8107249"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_110170"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131109_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUG5"/>
    <dbReference type="OrthoDB" id="4307211at2759"/>
    <dbReference type="PhylomeDB" id="B8MUG5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="125" mass="13593" checksum="1423A2474830113A" modified="2009-03-03" version="1">MASTAALEVEAYVLPTNLRLKQRAQIVAARLSTLPEDHPGRSGPRFPLAETLRTMDLTRLQALETIDPTPPPPWQTPAFIEIDIELDWDKAKDKASARQKASSIMVFSDVSGQQNALGAAAVALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUU9</accession>
    <name>B8MUU9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_110490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488625.1">
        <property type="nucleotide sequence ID" value="XM_002488580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUU9"/>
    <dbReference type="GeneID" id="8107281"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_110490"/>
    <dbReference type="HOGENOM" id="CLU_1679131_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUU9"/>
    <dbReference type="PhylomeDB" id="B8MUU9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="157" mass="18358" checksum="B9B653E8208ED97E" modified="2009-03-03" version="1">MTLLSKSKDVTIHWVFKVYNKLFDHLEKSIRQLRRKRVAWKQVMLASLEAAKNKLSIYYKDTDNMDDWDPEEGGIDYQAIYRQSLESSLEKYSENLAQEQQIVDAPPTSTAMDEFDLACTQSQMPNLEPGGNITKMNSLEWRGLHEMFFLFQLVVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8MV12</accession>
    <name>B8MV12_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_110810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488658.1">
        <property type="nucleotide sequence ID" value="XM_002488613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MV12"/>
    <dbReference type="GeneID" id="8101453"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_110810"/>
    <dbReference type="HOGENOM" id="CLU_133424_0_0_1"/>
    <dbReference type="InParanoid" id="B8MV12"/>
    <dbReference type="OrthoDB" id="4354814at2759"/>
    <dbReference type="PhylomeDB" id="B8MV12"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="109" mass="12254" checksum="58F7B0FAE4551EFD" modified="2009-03-03" version="1">MTTTKKRISRHTRSSSEAIGEVLTRASKAYEMSINKLTIAQKELHDLRAAHEKEKQKRRRSKQQISHEQGTTREEAQALVQGRVEASQAVTTAPAEPELPSCYYCSGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8LSX6</accession>
    <name>B8LSX6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS multidrug transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_064400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340359.1">
        <property type="nucleotide sequence ID" value="XM_002340318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LSX6"/>
    <dbReference type="GeneID" id="8103904"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_064400"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_3_1"/>
    <dbReference type="InParanoid" id="B8LSX6"/>
    <dbReference type="OMA" id="YINLCLG"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="PhylomeDB" id="B8LSX6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000024">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF67">
        <property type="entry name" value="MFS MULTIDRUG EFFLUX TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="480"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="590"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="121"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED22972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="627" mass="68058" checksum="5C54597FEDC263C9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>B8LT36</accession>
    <name>B8LT36_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA replication licensing factor MCM4</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">DNA replication licensing factor mcm4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSTA_069620</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340931.1">
        <property type="nucleotide sequence ID" value="XM_002340890.1"/>
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    <dbReference type="AlphaFoldDB" id="B8LT36"/>
    <dbReference type="FunCoup" id="B8LT36">
        <property type="interactions" value="1008"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LT36"/>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_069620"/>
    <dbReference type="eggNOG" id="KOG0478">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_7_1_1"/>
    <dbReference type="InParanoid" id="B8LT36"/>
    <dbReference type="OMA" id="AFFKCNV"/>
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    <dbReference type="PhylomeDB" id="B8LT36"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
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        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17755">
        <property type="entry name" value="MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000011">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000217">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MCM"/>
    </dbReference>
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        <property type="entry name" value="MCM_4"/>
    </dbReference>
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        <property type="entry name" value="MCM_CS"/>
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        <property type="entry name" value="MCM_dom"/>
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        <property type="entry name" value="MCM_lid"/>
    </dbReference>
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        <property type="entry name" value="MCM_N"/>
    </dbReference>
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        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF17207">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21128">
        <property type="entry name" value="WHD_MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="18">
        <location>
            <begin position="590"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="331"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="851"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073498"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00074938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EED23544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1008" mass="111185" checksum="6B3F5F0655F9AB5A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTG9</accession>
    <name>B8LTG9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7136 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_065070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_065070"/>
    <dbReference type="HOGENOM" id="CLU_1251412_0_0_1"/>
    <dbReference type="InParanoid" id="B8LTG9"/>
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    <dbReference type="PhylomeDB" id="B8LTG9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055560">
        <property type="entry name" value="DUF7136"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23584">
        <property type="entry name" value="DUF7136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7136" evidence="1">
        <location>
            <begin position="22"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="221" mass="23537" checksum="442F9F3FA0B70E6F" modified="2009-03-03" version="1">MPYRKVGENQEPGGVVNDYWATTFTAANTTTEPYILVNQTDVQKWQFGPWYPNGPVYALQWPISWDGSIKTCDSSPLGLFGTLFFNININSPEPDLKSLVGECPQLGGAYEINTTAKNSSCSAVVSNSSNGDSCAVPLNKTTVGSISSALQSLITASASTAAASVTVTPSRPAHNIAVSSDVPLLHVLVAIFLLGRYKGTFTRCGDLISNDPPWGGERECV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUE4</accession>
    <name>B8LUE4_TALSN</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_071200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341104.1">
        <property type="nucleotide sequence ID" value="XM_002341063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUE4"/>
    <dbReference type="GeneID" id="8106019"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_071200"/>
    <dbReference type="eggNOG" id="ENOG502S6DV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044597_2_0_1"/>
    <dbReference type="InParanoid" id="B8LUE4"/>
    <dbReference type="OMA" id="WESESLW"/>
    <dbReference type="OrthoDB" id="5358702at2759"/>
    <dbReference type="PhylomeDB" id="B8LUE4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008318">
        <property type="term" value="F:protein prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF3">
        <property type="entry name" value="PROTEIN PRENYLTRANSFERASE ALPHA SUBUNIT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED23717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="351" mass="40237" checksum="4D9FCDC8C2F00738" modified="2009-03-03" version="1">MTSESAEEIYKSLYEIFANRKSDQILEIEILTPDLGPLLQDGLCIGITKAALVKSFLVARQKLMKYLVHRSENVGYGTASLKQSEGVKELAVATQIILLFDCEHVTACNWRKRFISSSVQDHSINKDMSGLEEMLQRERSLLASFLCSPLHRHTKSPTLWQHRLWILTKLLDLQEQAAVKSEIWNEFLRKLILQELDVVCKSGQLHPRNYYAFSYMRQLHALVCQYDSPKEETLLKEASENTSQALLLTLALVMVEPMLKWWSSFALKDKMAKERKWALKRTIHFAVHIAAWESESLWTFVDLMVARFGVDILPAVDTDVSAIGDNGISAGARWQKTKLNVYKIYETRNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUK3</accession>
    <name>B8LUK3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histone acetyltransferase Spt10, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_072530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341247.1">
        <property type="nucleotide sequence ID" value="XM_002341206.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341248.1">
        <property type="nucleotide sequence ID" value="XM_002341207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUK3"/>
    <dbReference type="FunCoup" id="B8LUK3">
        <property type="interactions" value="1169"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LUK3"/>
    <dbReference type="GeneID" id="8104216"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_072530"/>
    <dbReference type="eggNOG" id="ENOG502QRFX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_42_5_1"/>
    <dbReference type="InParanoid" id="B8LUK3"/>
    <dbReference type="OMA" id="KQHAGIN"/>
    <dbReference type="OrthoDB" id="10264707at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052742">
        <property type="entry name" value="Mito_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015416">
        <property type="entry name" value="Znf_H2C2_histone_UAS-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138:SF2">
        <property type="entry name" value="PROTEIN SPT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09337">
        <property type="entry name" value="zf-H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="65"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="511" mass="57704" checksum="7C7C6656EE782C70" modified="2009-03-03" version="1">MPGVHEDIGSEVIPNPQEYAGTICPRQFTLRDRVTVATLVPFISVAQVPHGLLRYLSDQLNKEIEKGDTYTMIDPIPLEKFAPWWFSNIGAVMLLGDIQDVHDVNIMEHNGTDWTKVCLGSFNIRPNYPGRSSHVCNGMFLVTDASRNKGVGKLMGEGFLEWAPRLGYTYCVFNLVYESNIASCRMWDSLGFKRIGRVPGAGHIKSYPGQPVDGIIYGRDLSIEGDESVTQERFDKIRYYLKHAKYPRGADRAEKSRLRSAATHYKLVGGEDGEPERLMLKDKEVVSDPQQQYEIARRVHLEHHGGINKTTATVALKYHWVRIKETVSRVIRDCPKCKEASKAPPILNGGRTSEPPVIKPISEIETAVTNSLISHSEHLMADATHVHASPFTQTHTTEVHTMADDSMSDYTHLPLDPQMIDMNTHLSRFQHHHGMATGYDQSHGLPHAVFEDDLRGHHHNDYQAMVNDESDSEALQRDALNLVNTQLTDSQHEQEMLSRYVDRSDDELDFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUM2</accession>
    <name>B8LUM2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_072690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341266.1">
        <property type="nucleotide sequence ID" value="XM_002341225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUM2"/>
    <dbReference type="STRING" id="441959.B8LUM2"/>
    <dbReference type="GeneID" id="8102361"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_072690"/>
    <dbReference type="eggNOG" id="KOG1066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000631_9_0_1"/>
    <dbReference type="InParanoid" id="B8LUM2"/>
    <dbReference type="OMA" id="LPRGRWY"/>
    <dbReference type="OrthoDB" id="1334205at2759"/>
    <dbReference type="PhylomeDB" id="B8LUM2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF165">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="7">
        <location>
            <begin position="36"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="6">
        <location>
            <begin position="252"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="8">
        <location>
            <begin position="613"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED23879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="847" mass="94915" checksum="3204A03DBB4A8E10" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8LV84</accession>
    <name>B8LV84_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_065870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340521.1">
        <property type="nucleotide sequence ID" value="XM_002340480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LV84"/>
    <dbReference type="STRING" id="441959.B8LV84"/>
    <dbReference type="GeneID" id="8106204"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_065870"/>
    <dbReference type="HOGENOM" id="CLU_2591408_0_0_1"/>
    <dbReference type="InParanoid" id="B8LV84"/>
    <dbReference type="OMA" id="MAKHRNS"/>
    <dbReference type="OrthoDB" id="4842715at2759"/>
    <dbReference type="PhylomeDB" id="B8LV84"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED23134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="80" mass="8596" checksum="B106D120CD92FEDF" modified="2009-03-03" version="1">MTASLLTLDVKGAFDAMLPGRLIRRLREQGWPINLVLWIASFATGRSVQIQLDGEIGPSTDITCGLPQGSPETQGTDLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVE0</accession>
    <name>B8LVE0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_073460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF13 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341346.1">
        <property type="nucleotide sequence ID" value="XM_002341305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVE0"/>
    <dbReference type="FunCoup" id="B8LVE0">
        <property type="interactions" value="406"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LVE0"/>
    <dbReference type="GeneID" id="8102374"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_073460"/>
    <dbReference type="eggNOG" id="KOG3901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076665_1_1_1"/>
    <dbReference type="InParanoid" id="B8LVE0"/>
    <dbReference type="OMA" id="QLMKDAD"/>
    <dbReference type="OrthoDB" id="10266074at2759"/>
    <dbReference type="PhylomeDB" id="B8LVE0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF5">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="134"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED23959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="175" mass="19473" checksum="015E4E4C1CCFCB5B" modified="2009-03-03" version="1">MAEPRARAARHKGQMNFAGDLRTLLSGYGDRDAHPYCPPGPLPETVRVLDEIVTDFILEMCHEAAAYASYARRQKIKVDDFRFALRRDPHKLGRVQQLLQMDRELKDARKIFDHDDDQVGTAGRKVAEELDVSVDGTVATGTGNKKAKGKGKRNAGRRGSDATDENALKKRKVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVL2</accession>
    <name>B8LVL2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-like modifier SUMO, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_075160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341529.1">
        <property type="nucleotide sequence ID" value="XM_002341488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVL2"/>
    <dbReference type="FunCoup" id="B8LVL2">
        <property type="interactions" value="1132"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LVL2"/>
    <dbReference type="GeneID" id="8100214"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_075160"/>
    <dbReference type="eggNOG" id="KOG1769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148322_0_1_1"/>
    <dbReference type="InParanoid" id="B8LVL2"/>
    <dbReference type="OMA" id="MKIYCAR"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="PhylomeDB" id="B8LVL2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16116">
        <property type="entry name" value="Ubl_Smt3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000155">
        <property type="entry name" value="Ubiquitin-like protein SMT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10562">
        <property type="entry name" value="SMALL UBIQUITIN-RELATED MODIFIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="15"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED24142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="91" mass="10145" checksum="0BB9D6C26B6AE1AB" modified="2009-03-03" version="1">MADNASADGAAPAPEHLNIKVTDNHNEVFFKIKRTTQLKKLMDAFCERQGKQASTVRFLFDGTRVRPEDSPDTLDMQDGDTLEVHQEQIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVP3</accession>
    <name>B8LVP3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_075450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341560.1">
        <property type="nucleotide sequence ID" value="XM_002341519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVP3"/>
    <dbReference type="FunCoup" id="B8LVP3">
        <property type="interactions" value="1170"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LVP3"/>
    <dbReference type="GeneID" id="8100216"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_075450"/>
    <dbReference type="eggNOG" id="KOG1694">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066767_2_0_1"/>
    <dbReference type="InParanoid" id="B8LVP3"/>
    <dbReference type="OMA" id="KWYNADD"/>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="PhylomeDB" id="B8LVP3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000014">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049633">
        <property type="entry name" value="Ribosomal_eL6_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01170">
        <property type="entry name" value="RIBOSOMAL_L6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED24173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="199" mass="22314" checksum="AF41E599761AF96A" modified="2009-03-03" version="1">MSDAQTKKFGKGERTIPHHSQKAQKWYPVDDESQPKKVRKTARPAKPRESLQPGTILILLAGRFRGKRVVLLKHLPQGVLLVTGPFKINGVPLRRVNARYVIATSGKVDLSGIDSATLEKVSAADYFTKEKAQQKKTEEAFFKQGEKPEKKKITSARAADQKAIDQSLLANIKKEHLLASYLATSFSLRKGDKPHEMKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8LW88</accession>
    <name>B8LW88_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7905 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_074940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341503.1">
        <property type="nucleotide sequence ID" value="XM_002341462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LW88"/>
    <dbReference type="STRING" id="441959.B8LW88"/>
    <dbReference type="GeneID" id="8099949"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_074940"/>
    <dbReference type="eggNOG" id="ENOG502S50B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_652426_0_0_1"/>
    <dbReference type="InParanoid" id="B8LW88"/>
    <dbReference type="OrthoDB" id="4739136at2759"/>
    <dbReference type="PhylomeDB" id="B8LW88"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057227">
        <property type="entry name" value="DUF7905"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25482">
        <property type="entry name" value="DUF7905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7905" evidence="1">
        <location>
            <begin position="56"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED24116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="421" mass="47975" checksum="743C0E9DC64240A9" modified="2009-03-03" version="1">MSSHIIKRKAYLMGLPCPGRYVKSILLKATPNPKEVIVTFVTSEIQLTCMLIDNAQLWSKNIDQLSSALMQSLRVVPQLRGTAQMRVTLGSFIFEQYRRPKDHENGYSFDEFGDMLSQEMTRGHITSTLEPDQIIDHINRASHLFVLENGQGPVSTACRSVKVEFASRTGTSLHLEVEFQAHGGQYEKVRTCWVETEFDRARPEKRPVLQAVMLNPERADWELKIREKTILNPGQLSPSMRDVQASLQFNHDTPGNALVTPAKQHCMLPSNAQIYRLIEKSTMQYPIKETDYVLEIARYDIYYPKVCPIRHNADASSYMEFKTPTSFTEAVLYGRTWDTRLKNINQARDLNSVLAALFQPRQRETPRAAFERFIMITTNVAGLWNPAGLQPMVSIPRPSSQSYTSMAQPRHVPEGILIDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8LX29</accession>
    <name>B8LX29_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_061670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340066.1">
        <property type="nucleotide sequence ID" value="XM_002340025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LX29"/>
    <dbReference type="GeneID" id="8104225"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_061670"/>
    <dbReference type="eggNOG" id="ENOG502RB46">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029138_1_0_1"/>
    <dbReference type="InParanoid" id="B8LX29"/>
    <dbReference type="OMA" id="TSEVMIW"/>
    <dbReference type="OrthoDB" id="2548233at2759"/>
    <dbReference type="PhylomeDB" id="B8LX29"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034:SF1">
        <property type="entry name" value="CONDENSATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED22679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="52193" checksum="6917D638ED190B0D" modified="2009-03-03" version="1">MSWTKISSNHYRRPMGENERLIKFIGDRAHSAGREQWSVSTTATFIPSDNRSAKEWATPTLRDAWKLLRFRHPSIASTPSVDGDYLEYIVPKEDDLEDWIKETYIVVKTKNSEDVIAEMKPGPFMTLHFLPHNWEIVLHTSHWRTDGYGAFQLLNALLEAVKIVIDDGLPALPWGEEVTRLVPSVETALALPDCGIPATTASAIKYANTQVFLKDSVGVTYNGESMTRPGGTRAVRMQLSTEKTQSIQRATNERKIDMYAAIHAALAKVNLTYAKPTTSVTLENEKEYASTIRLSLRPLLISPFTENPSVAAGLYTGGYIFKVTLNDHFLKIARQYQDQYENGASSEFVQSRRQFAAMALSGLQKGLLLSNPPPSNIDISFVVGVDEMVKSGFDTKQGRLEVSRVGLGVETLTRQPCLFFWLFRGQLDLSLVYNEAYQDAEQVHKMLNGVVEVLEHHGSTYIGIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXL2</accession>
    <name>B8LXL2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-ubiquinone oxidoreductase complex 1/LYR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_078680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341900.1">
        <property type="nucleotide sequence ID" value="XM_002341859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXL2"/>
    <dbReference type="STRING" id="441959.B8LXL2"/>
    <dbReference type="GeneID" id="8101191"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_078680"/>
    <dbReference type="eggNOG" id="ENOG502S4S4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141157_3_0_1"/>
    <dbReference type="InParanoid" id="B8LXL2"/>
    <dbReference type="OMA" id="HRAFMSK"/>
    <dbReference type="OrthoDB" id="10258445at2759"/>
    <dbReference type="PhylomeDB" id="B8LXL2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090324">
        <property type="term" value="P:negative regulation of oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20265">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045296">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052000">
        <property type="entry name" value="ETFRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024:SF0">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN REGULATORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE SOLUBLE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED24513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="68" mass="8125" checksum="99FDC1DB64170EA2" modified="2009-03-03" version="1">MTTQELRRRVIQVYKELLYLGREYPLGYDYFRTRLHGAFAVKMNLTDAKEIEEGIKRAEFVKKEVEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXU0</accession>
    <name>B8LXU0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSTA_062420</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340142.1">
        <property type="nucleotide sequence ID" value="XM_002340101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXU0"/>
    <dbReference type="FunCoup" id="B8LXU0">
        <property type="interactions" value="610"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LXU0"/>
    <dbReference type="GeneID" id="8102669"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_062420"/>
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            <end position="291"/>
        </location>
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            <end position="368"/>
        </location>
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            <end position="352"/>
        </location>
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            <begin position="353"/>
            <end position="368"/>
        </location>
    </feature>
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        <source>
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        <source>
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        <source>
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        </source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED22755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="891" mass="103037" checksum="D7E81638A6B3D172" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXX1</accession>
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        <name evidence="2" type="ORF">TSTA_062730</name>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <location>
            <begin position="1"/>
            <end position="18"/>
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            <begin position="19"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED22786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="85" mass="9246" checksum="3CC8211B55A87628" modified="2009-03-03" version="1">MQFFTNLTTLFLVTLALGAVIDTRTDALGVDKEVESVTCSPKGGACIEGQLSCCEGLRCYVPPKSGWEPQGAWTLQAYKILDMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8LY45</accession>
    <name>B8LY45_TALSN</name>
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        <submittedName>
            <fullName evidence="3">Secretory pathway protein Ssp120, putative</fullName>
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        <name evidence="3" type="ORF">TSTA_067300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED23290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="AlphaFoldDB" id="B8LY45"/>
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        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="GeneID" id="8100242"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_067300"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="B8LY45"/>
    <dbReference type="OMA" id="ADWMTKH"/>
    <dbReference type="OrthoDB" id="289247at2759"/>
    <dbReference type="PhylomeDB" id="B8LY45"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040250">
        <property type="entry name" value="Nucleobindin"/>
    </dbReference>
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        <property type="entry name" value="NUCLEOBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NUCLEOBINDIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877432" evidence="2">
        <location>
            <begin position="20"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED23290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="198" mass="22762" checksum="0AD79D0C01C62597" modified="2009-03-03" version="1">MRGIIVALLALATVAYGHGHHDDNGEVETDWATRHMREEHHIDSFDAGSFFALHDYDNSGDWRNDEIMKTYGLLDSSNTHLGAEQKDAVVNEVLRLFNPSGTGTVSRDEWMSQVQAGVRLPDFGYGPGHHGDIEYEYEIHHFEKFHGEDAKEEDLTHPEDIEHFRLHDEMELAEERLQQLESMQIVEGNIPRKFLRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8LY95</accession>
    <name>B8LY95_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">hydroxyacid-oxoacid transhydrogenase</fullName>
            <ecNumber evidence="4">1.1.99.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_067720</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate</text>
            <dbReference type="Rhea" id="RHEA:23048"/>
            <dbReference type="ChEBI" id="CHEBI:11047"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + succinate semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:24734"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16724"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.24" evidence="4"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340727.1">
        <property type="nucleotide sequence ID" value="XM_002340686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LY95"/>
    <dbReference type="FunCoup" id="B8LY95">
        <property type="interactions" value="541"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LY95"/>
    <dbReference type="GeneID" id="8101249"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_067720"/>
    <dbReference type="eggNOG" id="KOG3857">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007207_0_7_1"/>
    <dbReference type="InParanoid" id="B8LY95"/>
    <dbReference type="OMA" id="NLMGAGC"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="PhylomeDB" id="B8LY95"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047988">
        <property type="term" value="F:hydroxyacid-oxoacid transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08190">
        <property type="entry name" value="HOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000009">
        <property type="entry name" value="Fe-containing alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000003">
        <property type="entry name" value="Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042157">
        <property type="entry name" value="HOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF83">
        <property type="entry name" value="HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="9">
        <location>
            <begin position="77"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="10">
        <location>
            <begin position="299"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED23340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="497" mass="53504" checksum="9E8D7DC8C88DAD96" modified="2009-03-03" version="1">MTVPVIRVAPSAANRAVSLLRTIQFTHPPNCPCHTNPGHHHHNQRQQISLANNVRRHLATPTDPSQQKEYAFEMAASSIRFGPGATKEVGMDFKNLGAKRVCIVTDTNVAQLDAMKQATEGLAREGVEFTVFDKVRTEPKDSSIKEAIAFAKPYNPDAFLAVGGGSVIDTAKLMNLYTVFHDADFLDFVNAPLGKGLPVTKPLKPLVAVPTTAGTGSETTGTAIFDLVSKKAKTGVAHRALKPTLGICDPLNTRTMPSAVHASSGLDVLCHSLESYTAIPYYERKPRPTNPINRPAYQGANPISDIFSLNALRSTVKYLPRAVRDPEDFEAQEQMLLAATLAGVGFGNAGVHLCHGMSYPISGQNPGYKHAGYNVDHPIIPHGVSVAVTAPAVFRFTAASNPDRHLEAAEAFGVDISNVKRESAGEVLGEAIAKFLVSLGDQPRGLKELGFSSADIDGLVEGTIPQKRVLMLAPSLSEELNAEKEELRTLFENSLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZ45</accession>
    <name>B8LZ45_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_083220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478052.1">
        <property type="nucleotide sequence ID" value="XM_002478007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZ45"/>
    <dbReference type="STRING" id="441959.B8LZ45"/>
    <dbReference type="GeneID" id="8105200"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_083220"/>
    <dbReference type="HOGENOM" id="CLU_127252_0_0_1"/>
    <dbReference type="InParanoid" id="B8LZ45"/>
    <dbReference type="OrthoDB" id="2976890at2759"/>
    <dbReference type="PhylomeDB" id="B8LZ45"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED21089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="142" mass="17085" checksum="CA2FDCC87688DAD3" modified="2009-03-03" version="1">MLVFQNDISIRMLKCHGIQYFKYWIRFFIQDWKRLQQIHKALHRFDEFTRLISMQSPQISLSLAVYYELSDLLQEIRDRENDFQDFDLDISRAAASAIEKYQKYYSFMDDSNTYYAAAILDPQVKTRLLEHEIPNSDARTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZN1</accession>
    <name>B8LZN1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_097030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479417.1">
        <property type="nucleotide sequence ID" value="XM_002479372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZN1"/>
    <dbReference type="GeneID" id="8103789"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_097030"/>
    <dbReference type="eggNOG" id="ENOG502SM07">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042688_1_0_1"/>
    <dbReference type="InParanoid" id="B8LZN1"/>
    <dbReference type="OMA" id="GAFWDNS"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="PhylomeDB" id="B8LZN1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="309" mass="34820" checksum="7EA2307A6E2EDAE2" modified="2009-03-03" version="1">MATAATLPSHGTTGFLGVFGGTKDDKPAYIDFPNKVANINPPANISIVAEDIRYAQPKPSFKTHGYEFLERKSVCTSEELAKGKTDPNINKYLYDVYMPEVANILKEVTGGTEVIPNEFRLRNQVQDGGDIVANKVGWGNVNVVHVDRDPSNAEVRLGTSLGEERAKELLAKYNRWASVNLWRPIGETVQKWPLCMVNTTKVPNWDYETHMTKVRNIGDPAEKERGEKTHETVLLPPTSETPYFYQYASQMTPDECLIFTSFHTDASKVVPHGAFWDNSSPEAAPPRRSIEARCWVFWDEKDLYISFCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZY9</accession>
    <name>B8LZY9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_081540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477884.1">
        <property type="nucleotide sequence ID" value="XM_002477839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZY9"/>
    <dbReference type="STRING" id="441959.B8LZY9"/>
    <dbReference type="GeneID" id="8104792"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_081540"/>
    <dbReference type="eggNOG" id="ENOG502T1HS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009123_4_0_1"/>
    <dbReference type="InParanoid" id="B8LZY9"/>
    <dbReference type="OMA" id="ILDIRTW"/>
    <dbReference type="OrthoDB" id="4837779at2759"/>
    <dbReference type="PhylomeDB" id="B8LZY9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23272">
        <property type="entry name" value="BED FINGER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23272:SF161">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN RICESLEEPER 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002874573" description="HAT C-terminal dimerisation domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="253"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED20921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="332" mass="38956" checksum="79FD783409B56291" modified="2009-03-03" version="1">MLVRIKKPAIFLMMLLSRIARSPQRIQKWDNWPGCTKAINYDVDTRWNSTFIMIERAEECRRQLKDTVNDELEIEALRLTSDDWRQLSNIKKILAPFNEYTEYISQDSLSIHMAARLYEELHSMLLAIRERQGDWKNLSAEATILVSDRISLLERYYDYVKCNDIYYIASILDPQIKTKWLKMLPDGEKIIVRIRAFLKKAYPAQKKPISTALSANYKSLEYRFLEAFQPIQYNISESDIDQYFDTPTISTGFDPNQSQTEFIRNWWKANKLEFPCMAKVAQDHLAILAAEVDVERLFNGGRDILGIRRFSMNGRTLGTLLRLKDAARWKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8M005</accession>
    <name>B8M005_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_081700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477900.1">
        <property type="nucleotide sequence ID" value="XM_002477855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M005"/>
    <dbReference type="STRING" id="441959.B8M005"/>
    <dbReference type="GeneID" id="8104808"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_081700"/>
    <dbReference type="eggNOG" id="ENOG502RPIV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093577_0_0_1"/>
    <dbReference type="InParanoid" id="B8M005"/>
    <dbReference type="OMA" id="AGPWCLR"/>
    <dbReference type="OrthoDB" id="4225668at2759"/>
    <dbReference type="PhylomeDB" id="B8M005"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED20937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="224" mass="25508" checksum="439604C73701BC44" modified="2009-03-03" version="1">MGCISRPIAFVKRVVVPDIDRRRKVLHKTCHPNLVNLTDVFINQETVYFTYEKSGLSLRELQDMDDVTFDRIAVATICKEVLKGLIYMQEELGLHHGHLDSDCVYVNEDGQVKIGDVGNSMLAKEENQGTAHDIQSVYNLAADLLDLSTSSEKDTMSFHLAEDFTLLPSDVTFQEVMTHPFLAIAQDPWYLAYLGLMYTFGLQQHTWFKTPLEQGKGRKFSERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0A1</accession>
    <name>B8M0A1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_084290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478161.1">
        <property type="nucleotide sequence ID" value="XM_002478116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0A1"/>
    <dbReference type="STRING" id="441959.B8M0A1"/>
    <dbReference type="GeneID" id="8101522"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_084290"/>
    <dbReference type="eggNOG" id="KOG1203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025711_1_0_1"/>
    <dbReference type="InParanoid" id="B8M0A1"/>
    <dbReference type="OrthoDB" id="10254604at2759"/>
    <dbReference type="PhylomeDB" id="B8M0A1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF50">
        <property type="entry name" value="UPF0659 PROTEIN YMR090W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002874655" description="NAD(P)-binding domain-containing protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="NAD(P)-binding" evidence="3">
        <location>
            <begin position="11"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED21198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="257" mass="28267" checksum="92A5EC6897A7CEE9" modified="2009-03-03" version="1">MKLPPKVLILGGHSKVALLLTSLLIARGCGVISLTNNPEHRSDILNLRQSNREGNVEVLVTDLEHIDTAYAARALLDRVDANYVIWMAATFSSSKISKFLMVSYLSSRGKKPEPGMTDRQWNDIANADEGQIPIYEKEKIEAEEFLDAMTAWRRRQAHLPAQFQSIHVMTGGLSDLPGRGKISLHPEPVSFEGEVSRQDVAEVIDQLLARSDTNGRYGVLGGENDIETAIAKAVGSQQLLAEGPVYKNIVGGFIPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0A6</accession>
    <name>B8M0A6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_084340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478166.1">
        <property type="nucleotide sequence ID" value="XM_002478121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0A6"/>
    <dbReference type="GeneID" id="8101527"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_084340"/>
    <dbReference type="HOGENOM" id="CLU_1448640_0_0_1"/>
    <dbReference type="InParanoid" id="B8M0A6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED21203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="187" mass="22329" checksum="D98D873FA72659E2" modified="2009-03-03" version="1">MFWRSKPYILQLFKPTLEEWDAEDNLRKCDEVKWREQNLSAIPGDLKEKFVTIIPLGGGWYVLCPKTKSEAMDIEKNYHAKRFPVQKGIGNRLSLTGSDFCSMEHDKRVKDCQAACNAYAEVFEEKWKIREPYWENRQKAFHTAFGVWRSRMRVVLKWKSHESWVHCIIECMNAYEVDWLIYGRQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0T8</accession>
    <name>B8M0T8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Exonuclease V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_087040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EXO5 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478434.1">
        <property type="nucleotide sequence ID" value="XM_002478389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0T8"/>
    <dbReference type="GeneID" id="8110110"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_087040"/>
    <dbReference type="eggNOG" id="KOG4760">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013225_1_0_1"/>
    <dbReference type="InParanoid" id="B8M0T8"/>
    <dbReference type="OMA" id="FRDECEW"/>
    <dbReference type="OrthoDB" id="354769at2759"/>
    <dbReference type="PhylomeDB" id="B8M0T8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045145">
        <property type="term" value="F:single-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019190">
        <property type="entry name" value="EXOV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464:SF4">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09810">
        <property type="entry name" value="Exo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="140"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED21471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="648" mass="73867" checksum="5D8A123E4F296FAA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1M0</accession>
    <name>B8M1M0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase family, NAD-binding Rossmann fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_093530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479070.1">
        <property type="nucleotide sequence ID" value="XM_002479025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1M0"/>
    <dbReference type="FunCoup" id="B8M1M0">
        <property type="interactions" value="277"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M1M0"/>
    <dbReference type="GeneID" id="8102597"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_093530"/>
    <dbReference type="eggNOG" id="KOG2742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_3_1_1"/>
    <dbReference type="InParanoid" id="B8M1M0"/>
    <dbReference type="OMA" id="KPICFEK"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="PhylomeDB" id="B8M1M0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF5">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="4">
        <location>
            <begin position="146"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED22107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="354" mass="38884" checksum="2BEE0CCDFA29CAF0" modified="2009-03-03" version="1">MAIGVALIGGGIWAKEEHLPAILASKDLELKAIYSRSLKSANDVAGEVKDTQKIDLYSEDSSQTFGDILKRDDIQAVVISLPIANQGTFIKRALLAKKHVLSEKPVSENVQDGVVLISWYNGVKEEFDNVTWSVAENFRYLESFKYARQQIEELGKIIGFRVRVYANITEDFKFYHTSWRKEPTHQGGYILDGGVHFTAGLRLLLGSDVFVERVAAFTTSLKEHLPPVDTVDAILKTNTGIQGTFQSSVATTLTGPEWTIACENGSVTVSSSTVTVLSVDGEEVVKEIPNERSGVPPEVRAWGEALAAGRQNPEQTPEEGLADLELIELMLRSGNHDGEPQKCKYQSSTAEVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1Q9</accession>
    <name>B8M1Q9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_093920</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479109.1">
        <property type="nucleotide sequence ID" value="XM_002479064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1Q9"/>
    <dbReference type="STRING" id="441959.B8M1Q9"/>
    <dbReference type="GeneID" id="8103720"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_093920"/>
    <dbReference type="eggNOG" id="ENOG502SJQG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015161_2_1_1"/>
    <dbReference type="InParanoid" id="B8M1Q9"/>
    <dbReference type="OMA" id="YMHELET"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="PhylomeDB" id="B8M1Q9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="71"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="580"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="598"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED22146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="744" mass="84922" checksum="2D8A7A9EC356A00F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8M202</accession>
    <name>B8M202_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pogo transposable element, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_086110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478343.1">
        <property type="nucleotide sequence ID" value="XM_002478298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M202"/>
    <dbReference type="STRING" id="441959.B8M202"/>
    <dbReference type="GeneID" id="8104576"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_086110"/>
    <dbReference type="eggNOG" id="KOG3105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_6_2_1"/>
    <dbReference type="InParanoid" id="B8M202"/>
    <dbReference type="OMA" id="IMAISKC"/>
    <dbReference type="OrthoDB" id="3945463at2759"/>
    <dbReference type="PhylomeDB" id="B8M202"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="78"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED21380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="495" mass="56213" checksum="2E190E27DCED24B8" modified="2009-03-03" version="1">MMLGSAGFVDSVTATTIELTLTEKVKKYRISPSNTYNFDEKGFNIGLCRTEKRIVSKSQLCLKKLLGAIQDGSTEFITLIACICANGIAIPPALIYQGESGDLQDTWLKDFDGSREKAYFATSEKGWTNEELGFSWLTKIFDPHTKAKAGNSKRLLLTDGHSSHVNLRFIEYCDRNNIILGILPPHSTHRLQPLDVGIFPPLAGAYSHEIDRLTQSSSGFSRITKASFWRLFYAAWKSTLTLQNIRSAFAAPGIHPFNPPKVLNILKKKTPSPISSDIENKRKSPGSVRAIRRTLKAIRQEKSDLSEATQLALKALQKYAVQNEILEHQQQGLVDALIGEKKRQKRGRPLGLINKDNPGEAQFFSPGRIEAARQQIQNIELQKEQGKIEAANRRTQKAFARQQKAQEIQERRETRIREREEKRRQKELEKEQLRVAREAQKEVKRAKERPAKQVNTKKRRYSKVIESNEEVSSKRPKTGISRSGRAINLPIRFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8M211</accession>
    <name>B8M211_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_086200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478352.1">
        <property type="nucleotide sequence ID" value="XM_002478307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M211"/>
    <dbReference type="STRING" id="441959.B8M211"/>
    <dbReference type="GeneID" id="8104585"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_086200"/>
    <dbReference type="eggNOG" id="ENOG502SIZG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_814260_0_0_1"/>
    <dbReference type="InParanoid" id="B8M211"/>
    <dbReference type="OrthoDB" id="5344325at2759"/>
    <dbReference type="PhylomeDB" id="B8M211"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED21389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="341" mass="38311" checksum="045FF9EA82545EA4" modified="2009-03-03" version="1">MLSRPILDFLVRYFVTKVNWIEQLLYAPWLLTQYQKWWNLDRLSSVADTEFPVLFLRICCYTSQFFPSWDYNIDSIKGVALADILKSHEEVIDVLTPICVRLDSRGSLVRVLHILFGGLGSLCLHRGTIKWANGTDELEKGMLRRAICDIHIRDEYFLFTILLIYDVFNERVLLAQLAQFWRNHGSSVKESEEYTVIATEERYDKFCSAFLLELSPLSLFNQICNGTNALAAASLALLEGVRTLHGMMGDSHTRLSGVIVPTFDAAVPLLRLCADNDFPGAIGTESQSQNIRSPHPLGAVTCGLTRSKCLQAARDALDSLQNLVEVSNQAEAGARILSHVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8M279</accession>
    <name>B8M279_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Smr domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_087790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478506.1">
        <property type="nucleotide sequence ID" value="XM_002478461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M279"/>
    <dbReference type="FunCoup" id="B8M279">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M279"/>
    <dbReference type="GeneID" id="8100908"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_087790"/>
    <dbReference type="eggNOG" id="KOG2401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069447_0_0_1"/>
    <dbReference type="InParanoid" id="B8M279"/>
    <dbReference type="OMA" id="DYIFREN"/>
    <dbReference type="OrthoDB" id="3231855at2759"/>
    <dbReference type="PhylomeDB" id="B8M279"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053020">
        <property type="entry name" value="Smr_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417:SF1">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="98"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED21543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="242" mass="27647" checksum="71E5044EC9D8B3CC" modified="2009-03-03" version="1">MSYEMNYLGARAFNHEQSSQAEEEYDRLRSLARQEANKRNNCFERSKQAYEDGDGARAKQLSEEGKEHGRRMQEYNKQASEFIFRENNASGRVPEDTIDLHGQFVEEAEDILEERIKYARQHGQTHLHVIVGRGNHSTNHVQKIKPRVEQVCRELGLQYATEENAGRIYINLAGGPAEMPLSQPHQPYQQQPHYGGGGGYPGQQQPHHQGQPQQGKQDDIEAIVEKVLPRVLRKLGDCCIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2G9</accession>
    <name>B8M2G9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CorA family metal ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_088690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478596.1">
        <property type="nucleotide sequence ID" value="XM_002478551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2G9"/>
    <dbReference type="STRING" id="441959.B8M2G9"/>
    <dbReference type="GeneID" id="8106966"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_088690"/>
    <dbReference type="eggNOG" id="ENOG502SJAG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023638_0_0_1"/>
    <dbReference type="InParanoid" id="B8M2G9"/>
    <dbReference type="OMA" id="GMNFAQF"/>
    <dbReference type="OrthoDB" id="3231000at2759"/>
    <dbReference type="PhylomeDB" id="B8M2G9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027310">
        <property type="entry name" value="Profilin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00414">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED21633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="59733" checksum="C5D508C9C280C96C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2V6</accession>
    <name>MDM12_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial distribution and morphology protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Mitochondrial inheritance component mdm12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mdm12</name>
        <name type="ORF">TSTA_094570</name>
    </gene>
    <organism>
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. Mdm12 is required for the interaction of the ER-resident membrane protein mmm1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10. The mdm12-mmm1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The mdm10-mdm12-mmm1 subcomplex further acts in the TOM40-specific pathway after the action of the mdm12-mmm1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of mmm1, mdm10, mdm12 and mdm34. A mmm1 homodimer associates with one molecule of mdm12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of mmm1 and mdm12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="1">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM12 family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EED22211" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22211.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479174.1">
        <property type="nucleotide sequence ID" value="XM_002479129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2V6"/>
    <dbReference type="SMR" id="B8M2V6"/>
    <dbReference type="STRING" id="441959.B8M2V6"/>
    <dbReference type="GeneID" id="8103785"/>
    <dbReference type="eggNOG" id="ENOG502S1MJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026794_0_0_1"/>
    <dbReference type="InParanoid" id="B8M2V6"/>
    <dbReference type="OrthoDB" id="3356905at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21672">
        <property type="entry name" value="SMP_Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03104">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027532">
        <property type="entry name" value="Mdm12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26544">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0445">Lipid transport</keyword>
    <keyword id="KW-0446">Lipid-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000384314" description="Mitochondrial distribution and morphology protein 12">
        <location>
            <begin position="1"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="389"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="491" mass="54300" checksum="74AEFB4E46F05F09" modified="2009-09-22" version="2">MSIDLNWEAATSGPDGEQLAERIRSFIHDKFQQVPLPRFIRSVNVHSFEFGSIAPELEIKDICDPFVDFYEESDSSEDEDGEGHDAESDTSSDRAADSTADKRDMRYGHDDRGNNGHIPNHHDHLRTSQWVAGGTDGHSTQSPLRSPIGLGDHLNAHFRSTTPNILPGVTSNLGYHLMMGNLSGTQTPLAAVAGGTPFGPGWPDAVMNQGSRMTDHTTGRTRREDHNKNETGSPSRPSTAHTNPTQLSHGRSAASSSNNTSNDPTVIYNDHTSSTTATTYGLHEGGDRPRDKHGHRIDQEEPPPSPTPHMRERRPEDFQVICRVKYAGDVKLSLTAEILLDYPMPSFVGLPLKLNITGITFDGVAVVAYIRRRAHLCFLSPEDADALLGDEDDIQHPSYSTANTTTAASGSSTDNNNNNNESNDHPNHPPQPRRRFGSLLQQIRVDSEIGRKENGKQALKNVGKVERFVLDQVRRIFEDEFVFPSYWTFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B8M523</accession>
    <name>B8M523_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ADP-ribosylation factor 6, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_029100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480063.1">
        <property type="nucleotide sequence ID" value="XM_002480018.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480064.1">
        <property type="nucleotide sequence ID" value="XM_002480019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M523"/>
    <dbReference type="FunCoup" id="B8M523">
        <property type="interactions" value="91"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M523"/>
    <dbReference type="GeneID" id="8099029"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_029100"/>
    <dbReference type="eggNOG" id="KOG0071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_9_3_1"/>
    <dbReference type="InParanoid" id="B8M523"/>
    <dbReference type="OMA" id="GGQISKM"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110115">
        <property type="term" value="C:Cdr2 medial cortical node complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051523">
        <property type="term" value="P:cell growth mode switching, monopolar to bipolar"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04149">
        <property type="entry name" value="Arf6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000832">
        <property type="entry name" value="ADP-ribosylation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041838">
        <property type="entry name" value="Arf6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED19629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="184" mass="20467" checksum="75E2283378F85BD3" modified="2009-03-03" version="1">MGGSVSKLMGKIFGSKEMRILMLGLDAAGKTTILYKLKLNQDVTTIPTVGFNVESVTYKNVKFNVWDVGGQDKIRPLWRHYYSGTQGLIFVVDSSDTARLNEARSELHKIINDREMKDALLLVFANKQDTPGHLSPEEITNALQLNKLKDRLWYVVPSVATEGTGIFEGLAWLSNNVKTPAPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5H6</accession>
    <name>B8M5H6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphoketolase, putative</fullName>
            <ecNumber evidence="7">4.1.2.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_030480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XFP family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.9" evidence="7"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480216.1">
        <property type="nucleotide sequence ID" value="XM_002480171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5H6"/>
    <dbReference type="STRING" id="441959.B8M5H6"/>
    <dbReference type="GeneID" id="8101727"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_030480"/>
    <dbReference type="eggNOG" id="ENOG502QUUF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013954_2_0_1"/>
    <dbReference type="InParanoid" id="B8M5H6"/>
    <dbReference type="OMA" id="VAGKQPC"/>
    <dbReference type="OrthoDB" id="2532903at2759"/>
    <dbReference type="PhylomeDB" id="B8M5H6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050193">
        <property type="term" value="F:phosphoketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02011">
        <property type="entry name" value="TPP_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01403">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023962">
        <property type="entry name" value="Phosphoketolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003617">
        <property type="entry name" value="PRK05261.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003619">
        <property type="entry name" value="PRK05261.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273:SF0">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal" evidence="6">
        <location>
            <begin position="30"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal" evidence="5">
        <location>
            <begin position="608"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED19782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="815" mass="91736" checksum="CA05BE4206999155" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5R5</accession>
    <name>B8M5R5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_032940</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480476.1">
        <property type="nucleotide sequence ID" value="XM_002480431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5R5"/>
    <dbReference type="STRING" id="441959.B8M5R5"/>
    <dbReference type="GeneID" id="8105033"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_032940"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8M5R5"/>
    <dbReference type="OrthoDB" id="4215864at2759"/>
    <dbReference type="PhylomeDB" id="B8M5R5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11040">
        <property type="entry name" value="CYP7_CYP8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED20042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="502" mass="57119" checksum="24E13D52224599FD" modified="2009-03-03" version="1">MTQRSYLTGSRLSDMLSPSLLTSMDHWKMLCRFPPTTTASHLIESLSKKNGSSKEPFAITMAGKPIYLLTNPKDIAETYRHEDTLSMDMVVKDLYSRTGISMDKVNRLFIANPESPHNKGLPRPLHYIDISMEYFRWELSPGESLDRFVNEAAIPAILKAFDFDRTPAHSAVLHNDSDDSLVVSLEHLCIEALISGVVDIYYGPALWKINPDFVHSFMMWERVNWKYIFQLPGFLSKDMLEAKRDLVDTFVTYFEMDRTERDCGNLFVNSVEDTLREAGMGNEEIGRIFFLHSWAILGNMYKTAFWIIAHLVYNPSLLEAIRIEVTPAITKGEVDHQYLSKDCILLDSLYADVLRATMSSPMVRDITETTTIGGKKLRKGNRIMVSYRQLHLNTDVWGPTPELVQPDRFLRDKSLKTNNSYRPWGGGSTLCPGRFFAKKTIFTFISVLLVRYSAIHIKEETVGDNKGGRKPAFPRADFSKPIPGIVSPMMGDDISLILRESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8M600</accession>
    <name>B8M600_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pentachlorophenol 4-monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_033690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480561.1">
        <property type="nucleotide sequence ID" value="XM_002480516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M600"/>
    <dbReference type="STRING" id="441959.B8M600"/>
    <dbReference type="GeneID" id="8097786"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_033690"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_20_1_1"/>
    <dbReference type="InParanoid" id="B8M600"/>
    <dbReference type="OMA" id="WQNHIER"/>
    <dbReference type="OrthoDB" id="2096480at2759"/>
    <dbReference type="PhylomeDB" id="B8M600"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21274">
        <property type="entry name" value="Rng_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="5"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED20127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="518" mass="56513" checksum="783950031B9C3D90" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8M689</accession>
    <name>B8M689_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron-sulfur cluster-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_025800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479698.1">
        <property type="nucleotide sequence ID" value="XM_002479653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M689"/>
    <dbReference type="GeneID" id="8107992"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_025800"/>
    <dbReference type="eggNOG" id="ENOG502QQJW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026244_1_3_1"/>
    <dbReference type="InParanoid" id="B8M689"/>
    <dbReference type="OMA" id="FNWKVGA"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="PhylomeDB" id="B8M689"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03469">
        <property type="entry name" value="Rieske_RO_Alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF6">
        <property type="entry name" value="CLUSTER-BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="7">
        <location>
            <begin position="90"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED19264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="429" mass="47943" checksum="BDE6AC2F40C9FCE1" modified="2009-03-03" version="1">MTETSTFFVGILVGVVLGVISILGFTRYFALNESDKEHKRSPMEFKPAKKLNSMTKAESVVTKEAEFPPDWFSSTDNYNLETRAIFSKCWILLTHTSLFSKPGDYHTFTICGYSIFLILGKDFKIRAFHNVCRHRAYTVTRKESGSSTVLGCKYHGWSYDVMGRLVKAPMFDGVPGFRKDDNGLLEVPLRVSEESGTVWVNLDAARVNDGDIGGDKKEKEAVDLFLGLGGNKCRWVDGRTVEGGFNWKSAIVDSNTFNIGIPQRPRPSLLPSWLGKNHSHTSALHLFPCSTVYRIPNTNLWYSIILTPSSSTKTQIRWDLISSSTKSTIEAEKAIASQIEGMVSSQAKALEQSLQLVDDKNKDIQSAILVQLKSHLRVERALGKEVTPAMNKAKTSEKFLQAESLCKELDCLSGKTTRTNAQRHDILAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6F1</accession>
    <name>B8M6F1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Transaminase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_026370</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479760.1">
        <property type="nucleotide sequence ID" value="XM_002479715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6F1"/>
    <dbReference type="STRING" id="441959.B8M6F1"/>
    <dbReference type="GeneID" id="8098918"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_026370"/>
    <dbReference type="eggNOG" id="KOG1412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032440_1_2_1"/>
    <dbReference type="InParanoid" id="B8M6F1"/>
    <dbReference type="OMA" id="PTWPIHE"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="PhylomeDB" id="B8M6F1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000066">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF20">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="43"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED19326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="431" mass="48440" checksum="D2EA2123C0EA01E9" modified="2009-03-03" version="1">MLIEDQSANSATKSTSSFSSLPDAPVDEIFSLNHAYATDPNPNKVNLSLGVYRTEEGQPWPLSSVEQVEQELHSQNNPARHEYLPIEGDREFLDHARDLMFGFNKNDTDVEKEAKAKKRIASVQSISGTGANHLGAAFLAHHLKPKHVWVSIPTWANHHTIWELQGIERKGYPYFDASTCAFNFEGAITTLENEAEEGDVILLHACAHNPTGVDPSKEQWKKIAELCQRKRLFPFFDSAYQGFASGSADEDAWAVRYFFNLSPPLEMCVAQSFSKNFGLYGHRTGAFHLVTNGSKPAETELVRKNLCHIIRGEYSMGPRYGSTIVKRVLGDSALRAQWQKDLTAMSSRIKRMRQALYDELVRLNTPGSWEHIINQNGMFSYTGLTLKQVLTLRNEFHIYLLKSGRASVSGFSEKNVAYVAQAIDNVVRRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B8M727</accession>
    <name>B8M727_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">vesicle-fusing ATPase</fullName>
            <ecNumber evidence="3">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSTA_034820</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="3"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480681.1">
        <property type="nucleotide sequence ID" value="XM_002480636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M727"/>
    <dbReference type="FunCoup" id="B8M727">
        <property type="interactions" value="993"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M727"/>
    <dbReference type="GeneID" id="8104324"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_034820"/>
    <dbReference type="eggNOG" id="KOG0739">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_21_2_1"/>
    <dbReference type="InParanoid" id="B8M727"/>
    <dbReference type="OMA" id="IEWTNEF"/>
    <dbReference type="OrthoDB" id="29072at2759"/>
    <dbReference type="PhylomeDB" id="B8M727"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990621">
        <property type="term" value="C:ESCRT IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070676">
        <property type="term" value="P:intralumenal vesicle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090148">
        <property type="term" value="P:membrane fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036258">
        <property type="term" value="P:multivesicular body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02678">
        <property type="entry name" value="MIT_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19521">
        <property type="entry name" value="RecA-like_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000004">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000043">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000015">
        <property type="entry name" value="vacuolar protein sorting-associated protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045253">
        <property type="entry name" value="VPS4_MIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MIT" evidence="15">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="163"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="75"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EED20247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="433" mass="48039" checksum="78974E2FD419DE8E" modified="2009-03-03" version="1">MSNTDFLGRAIDTVKKAIEHDNAGEYEKAYQGYYAALELFMLALKWEKNPKSKEMIRAKTGEYMDRAEKLKNHLANADNKKKPSAVGANGKVANGGGKGKEDEDGEDAEAKKLRGALQGAILSEKPNVRWEDVAGLENAKEALKEAVILPIKFPHLFTGKRQPWKGILMYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWMGESERLVKQLFNMARENKPAIIFIDEVDALCGPRGEGESEASRRIKTELLVQMDGVGKDSRGVLILGATNIPWQLDAAIRRRFQRRIHISLPDINARMKMFMLAVGSTPCNLTQADYRHLAEISADYSGSDISIAVQDALMQPIRKIQTATHYKKVLVDGVEKFTPCSPGDNGAMEMNWMEVDSERLLEPPLVLKDFIKAIKNSRPTVSREDLERNAEWTKQFGSEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8M758</accession>
    <name>B8M758_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integral plasma membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_035070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480712.1">
        <property type="nucleotide sequence ID" value="XM_002480667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M758"/>
    <dbReference type="FunCoup" id="B8M758">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M758"/>
    <dbReference type="GeneID" id="8104349"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_035070"/>
    <dbReference type="eggNOG" id="KOG3979">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009808_0_0_1"/>
    <dbReference type="InParanoid" id="B8M758"/>
    <dbReference type="OMA" id="CVWYFPL"/>
    <dbReference type="OrthoDB" id="68581at2759"/>
    <dbReference type="PhylomeDB" id="B8M758"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="P:fungal-type cell wall organization"/>
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        <property type="entry name" value="Calcofluor white hypersensitive protein"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
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        <property type="entry name" value="PGAP2IP_TM_2nd"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF23022">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="580"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="611"/>
            <end position="629"/>
        </location>
    </feature>
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        <location>
            <begin position="650"/>
            <end position="670"/>
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        <location>
            <begin position="16"/>
            <end position="224"/>
        </location>
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        <location>
            <begin position="280"/>
            <end position="434"/>
        </location>
    </feature>
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        <location>
            <begin position="454"/>
            <end position="631"/>
        </location>
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        <location>
            <begin position="683"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23022"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23226"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED20278.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="949" mass="106000" checksum="1D395A80737CA52B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7M1</accession>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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        </lineage>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
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    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="F:quinone binding"/>
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        <property type="entry name" value="KR_dom"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SDR_fam"/>
    </dbReference>
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        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="adh_short"/>
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        <property type="entry name" value="GDHRDH"/>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
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        <location>
            <begin position="24"/>
            <end position="197"/>
        </location>
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        <location>
            <begin position="238"/>
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        </location>
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        <location>
            <begin position="241"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED19574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="295" mass="31069" checksum="092286CCC3704FB3" modified="2009-03-03" version="1">MAPQDRLNQVSSHLTFPQGLFHNQTVIVTGAGQGIGAEAARLFANEGAKVVVADIDQVKADAVVKAINDISPNRAIAVVGDVMDATYIDTLVKKSAEFGGGKIHVIVNNAGFTWDGVIHKITDKQWDTMLSVHNTAPFRLIRAAAPYFRVKDKEPRVIINISSTSGTHGNAGQANYSLAKAGLVGLTKTIAKEWGPQFGVRANTVAFGYITTRLTAAKEDGATFVAADGTKVALGIPGRKPSSSAQGSAVTAHNDIPLRRPGSPEEAARAIVGVASPWFSYVNGETIEVTGGRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7N7</accession>
    <name>B8M7N7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_028720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM9 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480024.1">
        <property type="nucleotide sequence ID" value="XM_002479979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7N7"/>
    <dbReference type="FunCoup" id="B8M7N7">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="GeneID" id="8098991"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_028720"/>
    <dbReference type="eggNOG" id="ENOG502RM85">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019189_13_1_1"/>
    <dbReference type="InParanoid" id="B8M7N7"/>
    <dbReference type="OMA" id="DWQSACV"/>
    <dbReference type="OrthoDB" id="2831558at2759"/>
    <dbReference type="PhylomeDB" id="B8M7N7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED19590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="602" mass="70389" checksum="9C5A703B10F1E2A5" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7P8</accession>
    <name>B8M7P8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_028830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480035.1">
        <property type="nucleotide sequence ID" value="XM_002479990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7P8"/>
    <dbReference type="STRING" id="441959.B8M7P8"/>
    <dbReference type="GeneID" id="8099002"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_028830"/>
    <dbReference type="eggNOG" id="ENOG502SIEM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099938_0_0_1"/>
    <dbReference type="InParanoid" id="B8M7P8"/>
    <dbReference type="OMA" id="IRVEPIT"/>
    <dbReference type="OrthoDB" id="2832510at2759"/>
    <dbReference type="PhylomeDB" id="B8M7P8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF14">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="87"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="258" mass="28970" checksum="30354B643533F676" modified="2009-03-03" version="1">MSSKIAQPNVITVKVEPVTAAEDFTRFFDVTALAFGQQVNDGIWTAMNSGWDTPKGREIGIHHLINRWSSTTKDRNGNPNTIFLKATVSRQDEPGKEDIAGAAIWVQASMVEGYGDMPTTDMDQSVLDELLPGNLEEQNYVRQLKFGLHRRRVEVVKEIASSSSPAVIVLDLCVVDPAYQRLGIATKLVEWGVSEAKRRGGLECILEASNMGRHVYKKLGFQQEGSEFEYQVDEQFQHRDRPSNIFMRTGYLGIRDYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7T1</accession>
    <name>B8M7T1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">endo-1,3(4)-beta-glucanase</fullName>
            <ecNumber evidence="4">3.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSTA_030740</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;3)- or (1-&gt;4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.</text>
            <dbReference type="EC" id="3.2.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.6" evidence="4"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480244.1">
        <property type="nucleotide sequence ID" value="XM_002480199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7T1"/>
    <dbReference type="STRING" id="441959.B8M7T1"/>
    <dbReference type="GeneID" id="8101753"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_030740"/>
    <dbReference type="eggNOG" id="ENOG502QUM3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016972_4_0_1"/>
    <dbReference type="InParanoid" id="B8M7T1"/>
    <dbReference type="OMA" id="CANFAAG"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="PhylomeDB" id="B8M7T1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000114">
        <property type="entry name" value="Probable endo-1,3(4)-beta-glucanase NFIA_089530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF58">
        <property type="entry name" value="ENDO-1,3(4)-BETA-GLUCANASE XGEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877366" description="endo-1,3(4)-beta-glucanase" evidence="17">
        <location>
            <begin position="21"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="18">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="325"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="581"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="325"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="415"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="581"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="635"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EED19810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="737" mass="73412" checksum="B5D5A7301E91AA07" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7W3</accession>
    <name>B8M7W3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_031060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480276.1">
        <property type="nucleotide sequence ID" value="XM_002480231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7W3"/>
    <dbReference type="GeneID" id="8107718"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_031060"/>
    <dbReference type="eggNOG" id="ENOG502QWBF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013756_2_1_1"/>
    <dbReference type="InParanoid" id="B8M7W3"/>
    <dbReference type="OMA" id="HRKFYAE"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="PhylomeDB" id="B8M7W3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF31">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14230)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED19842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="522" mass="58235" checksum="A6516B4162A08ADD" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8A7</accession>
    <name>B8M8A7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alkaline serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_036450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480854.1">
        <property type="nucleotide sequence ID" value="XM_002480809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8A7"/>
    <dbReference type="FunCoup" id="B8M8A7">
        <property type="interactions" value="1088"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M8A7"/>
    <dbReference type="GeneID" id="8101916"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_036450"/>
    <dbReference type="eggNOG" id="KOG0901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095071_3_0_1"/>
    <dbReference type="InParanoid" id="B8M8A7"/>
    <dbReference type="OMA" id="IRQSKPW"/>
    <dbReference type="OrthoDB" id="407959at2759"/>
    <dbReference type="PhylomeDB" id="B8M8A7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006344">
        <property type="entry name" value="PRK08571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED20420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="140" mass="14724" checksum="2AAC51C11B9C466F" modified="2009-03-03" version="1">MSKRGRGAAAGNKLKMTLGLPVGAVMNCCDNSGARNLYIISVTGAGARLNRLPAAGVGDMVMATVKKGKPELRKKVMPAVVVRQSKPWRRPDGIFLYFEDNAGVIVNAKGEMKGSAITGPVGKEAAELWPRIASNSGVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8T4</accession>
    <name>B8M8T4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_038080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481031.1">
        <property type="nucleotide sequence ID" value="XM_002480986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M8T4"/>
    <dbReference type="STRING" id="441959.B8M8T4"/>
    <dbReference type="GeneID" id="8102183"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_038080"/>
    <dbReference type="eggNOG" id="ENOG502SQJ6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042941_2_0_1"/>
    <dbReference type="InParanoid" id="B8M8T4"/>
    <dbReference type="OMA" id="FNESWHS"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="PhylomeDB" id="B8M8T4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED20597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="30889" checksum="AFDD981DC3044B60" modified="2009-03-03" version="1">MSVYEDGSVMSERVPDAKARTLTCEYCSLRLQDKRCERVLVYGLVTLIILLLANILFLFVQYSGFRSLSSPVTNTSTPAFDAVEYVEADLYDMYSIGDEYLGPPTAEREQNWRDLWQHEVTMVPKWAMPILNRSHVELYEQVESQSNEGFSAMLKVYHQLGCLDIIRQYTWIQAGRYPPDLIPPEMQKSPGELRSNIDRCIDDLRVSLMCAADVTPILITKDRDSSSEYKAELNSHHKCRNFTKLQDWTRTHGIEHWENGGGFHEHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9K2</accession>
    <name>B8M9K2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_117770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481996.1">
        <property type="nucleotide sequence ID" value="XM_002481951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9K2"/>
    <dbReference type="STRING" id="441959.B8M9K2"/>
    <dbReference type="GeneID" id="8105835"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_117770"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_6_1"/>
    <dbReference type="InParanoid" id="B8M9K2"/>
    <dbReference type="OMA" id="PYFISIM"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="PhylomeDB" id="B8M9K2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        </source>
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        </source>
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        </source>
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</entry>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED17441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="654" mass="74503" checksum="431309FE22785073" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B8MB15</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">TSTA_124400</name>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482708.1">
        <property type="nucleotide sequence ID" value="XM_002482663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MB15"/>
    <dbReference type="GeneID" id="8098391"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_124400"/>
    <dbReference type="HOGENOM" id="CLU_1856650_0_0_1"/>
    <dbReference type="InParanoid" id="B8MB15"/>
    <dbReference type="PhylomeDB" id="B8MB15"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="138" mass="16029" checksum="409103ED5BC3A415" modified="2009-03-03" version="1">MDIITCTYRSLHSVQSRQAFGTQAPILTIQRLIADAGLPKSHQSDLYEHHIELLTEVNRRRSRKKTKRQVQVGGVLTIMDANRATENRKLHEMEKNKTKMEREREEAREREAREKVQQQSLRANDEPIGENVVSDLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2024-01-24" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B8MB51</accession>
    <name>B8MB51_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_124710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482744.1">
        <property type="nucleotide sequence ID" value="XM_002482699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MB51"/>
    <dbReference type="STRING" id="441959.B8MB51"/>
    <dbReference type="GeneID" id="8100250"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_124710"/>
    <dbReference type="HOGENOM" id="CLU_1714531_0_0_1"/>
    <dbReference type="InParanoid" id="B8MB51"/>
    <dbReference type="PhylomeDB" id="B8MB51"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED18752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="153" mass="17510" checksum="1030B1618575554F" modified="2009-03-03" version="1">MKPRFLTYMVKYNKAVARKDLEVLSRFVSWYASLPDYPNSTEAFEGIARQCMEMIVYAQNEILQVRMRQLSLLKEQHGLFMSSIHNQGLEGLSLAVGQSSTYEYDYSQVGWGYATRYGAEAATQFQPALAMNPVRPGDTVEMTRLDAMWTKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBA4</accession>
    <name>B8MBA4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transposon, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_126040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482885.1">
        <property type="nucleotide sequence ID" value="XM_002482840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBA4"/>
    <dbReference type="GeneID" id="8098116"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_126040"/>
    <dbReference type="eggNOG" id="KOG3105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_4_0_1"/>
    <dbReference type="InParanoid" id="B8MBA4"/>
    <dbReference type="OrthoDB" id="4207519at2759"/>
    <dbReference type="PhylomeDB" id="B8MBA4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="208"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="660"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED18893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="706" mass="79340" checksum="6E93730ED15E0D52" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBS3</accession>
    <name>B8MBS3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_119670</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482198.1">
        <property type="nucleotide sequence ID" value="XM_002482153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBS3"/>
    <dbReference type="STRING" id="441959.B8MBS3"/>
    <dbReference type="GeneID" id="8105242"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119670"/>
    <dbReference type="eggNOG" id="ENOG502SMK9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_25_4_1"/>
    <dbReference type="InParanoid" id="B8MBS3"/>
    <dbReference type="OMA" id="INMGLIC"/>
    <dbReference type="OrthoDB" id="4525788at2759"/>
    <dbReference type="PhylomeDB" id="B8MBS3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="47"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="317"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED18206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="433" mass="48207" checksum="FEB3078B0D2C211D" modified="2009-03-03" version="1">MSNQLIPPASVIATWPAPNFVDPELRGPGLLVVNVVFSSLAFILTVLRVYTRGFITSTIGLDDVLAVLALSFAIAMCTATSIAAVKFGWDRHIWDVPFTWMPAMLKYRMVFEMTFCLSSILTKISLLWFCRRLLGSSAKSKFRYLNLSLIAAMVLLFILGLLFIFITLFTCIPLKASFDLLPDYPYHCIDGNAVVIAASVINVCTDFMTTVVPMPLIWKLQLPRRQRLAVIAIFGIGITVTIASSVRTYYAWMNTFGSYDATWYGWATGLSASVEINMGLICASAPALRPLIKTVWPRLLGGSGHGHGDSYQRFNGAKPWPPSNRSDNPHIRMGSNESTMKGPGILSRFDSTNEPGIVRTVELETFYEERKEVIYGRPVAANSVNARPLMEARNAHGGGTFFMNRRRDSFPSARHLKELYSDDEALFAVERMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8MC53</accession>
    <name>B8MC53_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2415 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_122330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482490.1">
        <property type="nucleotide sequence ID" value="XM_002482445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MC53"/>
    <dbReference type="STRING" id="441959.B8MC53"/>
    <dbReference type="GeneID" id="8097698"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_122330"/>
    <dbReference type="eggNOG" id="KOG4532">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8MC53"/>
    <dbReference type="OrthoDB" id="418169at2759"/>
    <dbReference type="PhylomeDB" id="B8MC53"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019417">
        <property type="entry name" value="DUF2415"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF9">
        <property type="entry name" value="DUF2415 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10313">
        <property type="entry name" value="DUF2415"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2415" evidence="2">
        <location>
            <begin position="318"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED18498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="746" mass="82172" checksum="74D2F64C544ADD7E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8MC84</accession>
    <name>B8MC84_TALSN</name>
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        <recommendedName>
            <fullName evidence="10">glucose oxidase</fullName>
            <ecNumber evidence="10">1.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSTA_122620</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2</text>
            <dbReference type="Rhea" id="RHEA:11428"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.1.3.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:11429"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.4" evidence="10"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482522.1">
        <property type="nucleotide sequence ID" value="XM_002482477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MC84"/>
    <dbReference type="STRING" id="441959.B8MC84"/>
    <dbReference type="GeneID" id="8097727"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_122620"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_0_1"/>
    <dbReference type="InParanoid" id="B8MC84"/>
    <dbReference type="OMA" id="QWDANAY"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="PhylomeDB" id="B8MC84"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046562">
        <property type="term" value="F:beta-D-glucose oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.450.10">
        <property type="entry name" value="Glucose Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027424">
        <property type="entry name" value="Glucose_Oxidase_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF218">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7 12" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877414" description="glucose oxidase" evidence="14">
        <location>
            <begin position="26"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="15">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="604"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="604"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="538"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="581"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EED18530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="669" mass="71382" checksum="EACD34BFEDC756FF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCR0</accession>
    <name>B8MCR0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_126700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482954.1">
        <property type="nucleotide sequence ID" value="XM_002482909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCR0"/>
    <dbReference type="STRING" id="441959.B8MCR0"/>
    <dbReference type="GeneID" id="8099097"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_126700"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_869269_0_0_1"/>
    <dbReference type="InParanoid" id="B8MCR0"/>
    <dbReference type="OMA" id="FEMIDIG"/>
    <dbReference type="OrthoDB" id="4501190at2759"/>
    <dbReference type="PhylomeDB" id="B8MCR0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="320" mass="36967" checksum="53403E6608320F2A" modified="2009-03-03" version="1">MYGLTAHLLDATNAFVGSKLDKQIYMEVPKGLPKSLQLGKDEVCELLQSLYGLRQSANLWCHKVKEFITSIRFKPSTADPGIFINERGMIIALYIDDILVFSKDEKAIRLTKKKLKEFHPMKDSGRVNKILGIRIIWLDGSIRLDQEFYTLRILEEFNMLEAKPQKLPLSPSINLDKDSRRLSREAHSQFRHAIGRLTYLAGGTQPDIQRTVNRLSQHLVEPKEIHLKAIKHLPHYLRGTYRYAISYLKGSKDKKLPEVLFVGQVANSQLLRHLHPKLNILLQLIQQSKQYGYVIFYIQFGNQELMTMAQYLCILTTPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCR5</accession>
    <name>B8MCR5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Monoxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_126750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482959.1">
        <property type="nucleotide sequence ID" value="XM_002482914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCR5"/>
    <dbReference type="STRING" id="441959.B8MCR5"/>
    <dbReference type="GeneID" id="8099102"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_126750"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_1_1"/>
    <dbReference type="InParanoid" id="B8MCR5"/>
    <dbReference type="OMA" id="ANESWVP"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="PhylomeDB" id="B8MCR5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF315">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE MDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="42"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED18967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="514" mass="57861" checksum="98C6FC4ECD743661" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MD56</accession>
    <name>B8MD56_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_113960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481573.1">
        <property type="nucleotide sequence ID" value="XM_002481528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MD56"/>
    <dbReference type="STRING" id="441959.B8MD56"/>
    <dbReference type="GeneID" id="8109158"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_113960"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_596085_0_0_1"/>
    <dbReference type="InParanoid" id="B8MD56"/>
    <dbReference type="OMA" id="YVGREIV"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="PhylomeDB" id="B8MD56"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051637">
        <property type="entry name" value="Ank_repeat_dom-contain_49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180:SF45">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="167"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="264"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="297"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="330"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED17581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="459" mass="50173" checksum="3243BE0096BCD880" modified="2009-03-03" version="1">MPGYAHEHTPTLRAHSQLARLPVELILKIGSLLQDSPADLCHFAALTSKNWSILREECHRIAVKLAEPTEEEFKKYLTETGDVDRLILWDQVQESDIHTRSKFTDAVSNGKLNVVDSFLQHGLSPNTCSIFGNRPLNLAANCPRPVEMSKLLLKHGADPNLTDILTDIFSPLYTAASLGHEDLVNVLLDCGADIKVKSAIQAICHICTEATIVRAFEMGADIHSIDEGGNNILHHGGRNESPAVLPILFKLGCPLEAVNKQNLQGKTPLMKAVKGGHVNNVTTLLAYNADPNTPLANGATALHVACNWDHVEIARLLIDAGAKVEVVNGDGWRPIHFAAYNYSTKMVELLVQHGADVTATDQQQNTALHLLLAEVTSNASKKFVKGILRKVKLLISANADPTAKNDSGDTPLSLAKNTGHYEIYHLLSTRDTHALDGKPPTGRDWKDYLREHVYVTEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDV8</accession>
    <name>B8MDV8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_011450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483269.1">
        <property type="nucleotide sequence ID" value="XM_002483224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MDV8"/>
    <dbReference type="STRING" id="441959.B8MDV8"/>
    <dbReference type="GeneID" id="8104986"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_011450"/>
    <dbReference type="eggNOG" id="ENOG502SRWU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035352_0_0_1"/>
    <dbReference type="InParanoid" id="B8MDV8"/>
    <dbReference type="OrthoDB" id="5343383at2759"/>
    <dbReference type="PhylomeDB" id="B8MDV8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877445" evidence="2">
        <location>
            <begin position="21"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED16035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="563" mass="64164" checksum="69950117323EAE8A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEA6</accession>
    <name>B8MEA6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secretory component protein shr3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_016120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16533.1"/>
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            <dbReference type="EMBL" id="EED16533.1"/>
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    </evidence>
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    </evidence>
    <sequence length="214" mass="23408" checksum="58F562210092B986" modified="2009-03-03" version="1">MALKSGSFATFLIVGPICFFLGIVFSLFPYDYPLLWAGEPTPPSHYDYLEAHLRFLHASPPLIPRILHIVIFVGFAGMLAKLYKPSESNMLFDGASLVLYVCGVTVYIANIVKGLRLVSGGIYGAELAGTDDDAEQVLGREDSLKVLAASNTILALILVGVLILQAGQWYAEKKDAQEFEKLNQKGAESSSKKERPESPVATRGTSRQNSKKRQ</sequence>
</entry>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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                <person name="Fedorova-Abrams N.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
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    <sequence length="542" mass="59343" checksum="97F72DFFFE639A24" modified="2009-03-03" version="1"> </sequence>
</entry>
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            <fullName evidence="4">LEA domain protein</fullName>
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            <taxon>Eurotiomycetidae</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_012930"/>
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    </dbReference>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
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    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_013170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483445.1">
        <property type="nucleotide sequence ID" value="XM_002483400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MG91"/>
    <dbReference type="GeneID" id="8108193"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_013170"/>
    <dbReference type="eggNOG" id="ENOG502T4JB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045820_1_0_1"/>
    <dbReference type="InParanoid" id="B8MG91"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="PhylomeDB" id="B8MG91"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039650">
        <property type="entry name" value="HdrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43498:SF1">
        <property type="entry name" value="COB--COM HETERODISULFIDE REDUCTASE IRON-SULFUR SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43498">
        <property type="entry name" value="FERREDOXIN:COB-COM HETERODISULFIDE REDUCTASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12831">
        <property type="entry name" value="FAD_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED16211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="49110" checksum="A8B565C51D8A928C" modified="2009-03-03" version="1">MLDMYKFGTVEFSPVKPYDIVIVGGGAAGIGAAIGARQAAQDATILIIESESCLGGAATHRGVCAFCGLFTVDEKPRQAVGRIWQELRQRLRALNGTTESPVRIRGVFQVVDPEALKLVLDDLMKDYNIDVLLHTTVVGATRSESNTIVSIDIQEKRGRSRVSAYAFVDCSGDCDLAYLAGASTRYGNHGTLNLGSLSVRFSGIDQNARPSISTWRDAIIAAKQKAPELSQILPKNGSALLHMPVSRDVIAFLPSAYYDTRSSASITAAEQSGRRQAQEYLRILRTLPGHEDMYVVSTGPNFGCRESRHMNSMYQLTEEDIMSDRRFSDVIAIGAWGFEFHDVEHENWESTFTYPPKGRFEIPLASLRSIDTPNLFAAGRCIDADQKASSAVRVMGTALATGQAAGVAAGLESMRGSKDLWDVTQVQDCLRAHGAFLDSASLPEGGPIEQIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGC3</accession>
    <name>B8MGC3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_013460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483477.1">
        <property type="nucleotide sequence ID" value="XM_002483432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGC3"/>
    <dbReference type="STRING" id="441959.B8MGC3"/>
    <dbReference type="GeneID" id="8099145"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_013460"/>
    <dbReference type="HOGENOM" id="CLU_013929_4_0_1"/>
    <dbReference type="InParanoid" id="B8MGC3"/>
    <dbReference type="OMA" id="WREMEIE"/>
    <dbReference type="OrthoDB" id="4207519at2759"/>
    <dbReference type="PhylomeDB" id="B8MGC3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="90"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED16243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="348" mass="40677" checksum="DBF17963BC946229" modified="2009-03-03" version="1">MWKSTGWREMEIESTISQKYNYERAKFEDPNIIQEYFDRVQEVIAEHGILQEDIYNFDETGFAMGLCAAAKVITGSDRYARPNLLPPCNREWATAIEAVDSIGWILPSYTIFKAKKYTRLGWFEDVPDDWRINISDNRWTTDNIGLEWLKTHFIPLTDGRILGKYRMLIFDGYGSHLTAEFDLTCTENNIIPVCMPPHSSHLLQPLDVGCFAVLKRHYEQLVEQRMRLGFNHNDKIDFLTAFPTTRTMAYKAQTVWNSFAATGLTPQITRQFTPQLTTVIRRIDQLTGSPNEVIDQAIMRMSKPYEKTVNDLLIVWKENKDLRAAHEKEKQKRQISHEQLRHSYKVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHT8</accession>
    <name>B8MHT8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_015070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483652.1">
        <property type="nucleotide sequence ID" value="XM_002483607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHT8"/>
    <dbReference type="GeneID" id="8106249"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_015070"/>
    <dbReference type="eggNOG" id="ENOG502RNVK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_839648_0_0_1"/>
    <dbReference type="InParanoid" id="B8MHT8"/>
    <dbReference type="OMA" id="HFRYVPA"/>
    <dbReference type="OrthoDB" id="4148828at2759"/>
    <dbReference type="PhylomeDB" id="B8MHT8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="330" mass="37864" checksum="5D55BC9116CCA7E5" modified="2009-03-03" version="1">MENIVNTSLDIIRRHKARHPRLHSRWGDVAITPPVEGAWSQFDNPYIRDEREYGPGFIPSLDISNKEVLLLESSTDGSDDELAKEKNIKEGRTGKEADSKAISKAKRLTRILLPSSVNSTVRKSADKGKANDFQYRPVQPDYAQEVVEKIDQQSRPHFRYVPASRHYLYNLKRHDIRLSDSENTYGHYDTDDDADDENEIKEKSRSGRQERQRSHSCDPDVGGRSFVVTTGRRKPRPFRGTPLETINSPTSTISLSDTMSSSTLSRSSGPRANSTSRLGEQEHSPRWHAMRRLDTKPQVITVQRSKSDVKKVKRRTMTLEMVRDQEDLWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8MI49</accession>
    <name>B8MI49_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_022650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484445.1">
        <property type="nucleotide sequence ID" value="XM_002484400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MI49"/>
    <dbReference type="GeneID" id="8107102"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_022650"/>
    <dbReference type="eggNOG" id="ENOG502RQKK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_776408_0_0_1"/>
    <dbReference type="InParanoid" id="B8MI49"/>
    <dbReference type="OMA" id="IHIERKG"/>
    <dbReference type="OrthoDB" id="5413827at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED17211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="295" mass="33767" checksum="2DE979980227D736" modified="2009-03-03" version="1">MAKRRQLPTIDQIESKLGYKLDYLDNVDDDIPTFYSDLTPVPNSAYERALREFDVARKQELKGADSSHGLPILGAPKTSSIFFRLPRELRDRIYMFSIPSCEWTLGDVDQFNSTTFAGALGDPTGFFFPLNKDLSVLLVNKQIRQEALPIAYRKTFFRLDDIDDFIKVIISIGQIGRANIESVEFSWESRSDLSYQMGKYLESDDNNSHLPALHVLRCVQLLKECRRLAFLRLYFEPDLISNMSIASFQADPGIRELSSVRGIRRVEIGTAVFEPLDHYDFIKWLKGKMESGSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIA1</accession>
    <name>B8MIA1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-alkyl-2-acetylglycerophosphocholine esterase</fullName>
            <ecNumber evidence="1">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_040650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.47" evidence="1"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484538.1">
        <property type="nucleotide sequence ID" value="XM_002484493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIA1"/>
    <dbReference type="STRING" id="441959.B8MIA1"/>
    <dbReference type="GeneID" id="8110022"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_040650"/>
    <dbReference type="eggNOG" id="KOG3847">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026278_0_0_1"/>
    <dbReference type="InParanoid" id="B8MIA1"/>
    <dbReference type="OMA" id="HGSFTDY"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="PhylomeDB" id="B8MIA1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000450">
        <property type="entry name" value="PAF acetylhydrolase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF14">
        <property type="entry name" value="PAF ACETYLHYDROLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877608" description="1-alkyl-2-acetylglycerophosphocholine esterase" evidence="5">
        <location>
            <begin position="25"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED14585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="386" mass="41530" checksum="6927FDC16B9C6EAC" modified="2009-03-03" version="1">MFKPSDKRLLLAALFTQLLPSINALSFPATVGSFNTSIATTLLVDHHRLDPYAPTPHPRTLMISLFHPVPPAECFSSLTSYMDPISATFEDNEYAPVGVPAGAFGSLTLETCKPCPASNPRRGVKGPNYPLVLFSPGLGNTRLLYSAIAQQLSSTGYIVVTIDHPYDASIVTFPDNTTILATNITTDTQIVDDLNIRVKDVSFVLDQLHRQSVISKLIPGRTCGLDTSKVGIYGHSLGGATAAEAMLSDSRLMGGVNLDGTFFGSVIDQGLDKPFMIMAHEGKNLTTDASWDALWPKLKGFRRGFMLSGSTHGTFTDLAEAADLIGLREQFPTQAAALLGSIDGERALQVISAYVSRFFDIVLKGKKSELLDGSSVEFPEVTVGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIB7</accession>
    <name>B8MIB7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G-protein beta WD-40 repeats containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_040800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484554.1">
        <property type="nucleotide sequence ID" value="XM_002484509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIB7"/>
    <dbReference type="STRING" id="441959.B8MIB7"/>
    <dbReference type="GeneID" id="8098899"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_040800"/>
    <dbReference type="eggNOG" id="KOG0271">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_6_16_1"/>
    <dbReference type="InParanoid" id="B8MIB7"/>
    <dbReference type="OMA" id="RWDNTIG"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="PhylomeDB" id="B8MIB7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035097">
        <property type="term" value="C:histone methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000228">
        <property type="entry name" value="COMPASS-like H3K4 histone methylase component WDR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001638">
        <property type="entry name" value="NACHT and WD40 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="79"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="599"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="641"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="683"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="725"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="767"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="809"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="851"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="893"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="935"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="977"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1019"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED14601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1211" mass="134062" checksum="BB8CFC32AB4121E7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIR7</accession>
    <name>B8MIR7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 12">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_050190</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 12"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485532.1">
        <property type="nucleotide sequence ID" value="XM_002485487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIR7"/>
    <dbReference type="FunCoup" id="B8MIR7">
        <property type="interactions" value="877"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MIR7"/>
    <dbReference type="GeneID" id="8108781"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_050190"/>
    <dbReference type="eggNOG" id="KOG1494">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047181_1_0_1"/>
    <dbReference type="InParanoid" id="B8MIR7"/>
    <dbReference type="OMA" id="ASCAEYI"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="PhylomeDB" id="B8MIR7"/>
    <dbReference type="Proteomes" id="UP000001745">
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    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
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    </dbReference>
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        <property type="entry name" value="L-lactate/malate_DH"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Ldh_1_C"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LDH C-terminal domain-like"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
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    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="25"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="170"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="30"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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        <location>
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        </ligand>
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        <ligand>
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        </ligand>
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        <location>
            <begin position="140"/>
            <end position="142"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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        </location>
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        <ligand>
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        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
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        </source>
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        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED15579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="340" mass="35826" checksum="20902FDDEA1BF1DA" modified="2009-03-03" version="1">MFAARQSFGVFQKRAFSASARQASKVTVLGAAGGIGQPLSLLMKLNPRVSQLALYDIRGGPGVAADLSHINTNSTVTGYEPTASGLKEALTDAEIVLIPAGVPRKPGMTRDDLFNTNASIVRDLAKAAADASPNAKILVISNPVNSTVPIVAEVFKSKGVYNPKRLFGVTTLDVVRASRFISQVKKTDPANEEVPVVGGHSGVTIVPLLSQSNHADIEGETRDALVNRIQFGGDEVVKAKDGAGSATLSMAFAGARFAESLLKAAQGVKGVIEPTFVDSPLYKDQGVEFFASRVELGPEGVKEILPVGQVNAYEEKLLEACLGDLKKNIKKGVDFVAQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJ09</accession>
    <name>B8MJ09_TALSN</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_051090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002485579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJ09"/>
    <dbReference type="STRING" id="441959.B8MJ09"/>
    <dbReference type="GeneID" id="8098181"/>
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    <dbReference type="eggNOG" id="ENOG502SI4Z">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_031559_3_2_1"/>
    <dbReference type="InParanoid" id="B8MJ09"/>
    <dbReference type="OMA" id="AWHNDAP"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="PhylomeDB" id="B8MJ09"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF3">
        <property type="entry name" value="DUF3431 DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="344" mass="38664" checksum="79811F31D3ACA1FC" modified="2009-03-03" version="1">MPRKVDRFVIQSAVFLGVLLLILYINRPQSAANKLLAWTEIRYKSTTNEQPDSRGACPSLAGSKKPALVVARVAADGDASWIDPLSKKYHPCIYTVDSPVDHASKYLQVPANRGHEAIVYLTFIIDNYYHIPEAGVVFVHGSRWAWHNDEPTYDNAALLKALDVHASLETWGYHNLRCDWSAMISPWDARAVSDFALPAAFETLFGKGQSNSKLGKHDTVRSQCCAQFIVGRKNILQHSLQEYIALRQWLLDTSHDAAPSDDRVAGRILSYLWHILFIKKEEIEENGAISLDKLNSAACPRAADCYCRLYGICNLDNCNDGHCYGRYEIPPDFRIPDDWAATHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJ57</accession>
    <name>B8MJ57_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GMC oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_051560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485672.1">
        <property type="nucleotide sequence ID" value="XM_002485627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJ57"/>
    <dbReference type="STRING" id="441959.B8MJ57"/>
    <dbReference type="GeneID" id="8103377"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_051560"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_3_1"/>
    <dbReference type="InParanoid" id="B8MJ57"/>
    <dbReference type="OMA" id="HGCSWWH"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="PhylomeDB" id="B8MJ57"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF138">
        <property type="entry name" value="DEHYDROGENASE PKFF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877632" evidence="5">
        <location>
            <begin position="24"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="54"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="7">
        <location>
            <begin position="476"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="549"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="593"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="594"/>
            <end position="595"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED15719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="620" mass="67435" checksum="BC1E0FD5C19F03D2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJH9</accession>
    <name>B8MJH9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Galactosyl transferase GMA12/MNN10 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_046330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485132.1">
        <property type="nucleotide sequence ID" value="XM_002485087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJH9"/>
    <dbReference type="STRING" id="441959.B8MJH9"/>
    <dbReference type="GeneID" id="8099544"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_046330"/>
    <dbReference type="eggNOG" id="ENOG502SDCI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039079_1_0_1"/>
    <dbReference type="InParanoid" id="B8MJH9"/>
    <dbReference type="OMA" id="FWNKPSY"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="PhylomeDB" id="B8MJH9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF8">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 34 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED15179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="41190" checksum="851E6B7D7D4F85A3" modified="2009-03-03" version="1">MPQGFTRRAIGALLTATALLLIWRISNYDVVTSLSPSSSSSSSANNQLSKSGGNPRRIAKVSMLYGNPNPLYERALRSHERHAQRWGYPMYVLEEDISEGFWNKPSYVLSLVIQELAKPPTKRCEWLMWVDADSIIINPAIPADIFLPPSDLSEIHFVASKDQNGLNTGIVFFHVHPWTVSMLVETLAHPLYLPDIDLGRSADQEAMARIMAKQTGGPEGQGYAAGMAYLPRPWINTYEWHHAYEGKKGDMLVHFPGLEDDRWPHMANWLDIVEKTPLEWEVPLKESGYDELTRVFWAKFRAARDLANSVQEDIWLEPAGSSTSMRQAAVNNVRLALQQHADEPEVLQQQVAELKAAVKEETSGRS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJJ2</accession>
    <name>RCF1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName>Respiratory supercomplex factor 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rcf1</name>
        <name type="synonym">aim31</name>
        <name type="ORF">TSTA_046460</name>
    </gene>
    <organism>
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with the respiratory chain complex III/complex IV supercomplex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RCF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485145.1">
        <property type="nucleotide sequence ID" value="XM_002485100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJJ2"/>
    <dbReference type="STRING" id="441959.B8MJJ2"/>
    <dbReference type="GeneID" id="8099557"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_046460"/>
    <dbReference type="eggNOG" id="KOG4431">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087356_0_2_1"/>
    <dbReference type="InParanoid" id="B8MJJ2"/>
    <dbReference type="OMA" id="YNENAFQ"/>
    <dbReference type="OrthoDB" id="6604018at2759"/>
    <dbReference type="PhylomeDB" id="B8MJJ2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF3">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000399660" description="Respiratory supercomplex factor 1, mitochondrial">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="3">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="83"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="188" mass="21431" checksum="7609553BD3C01959" modified="2009-03-03" version="1">MADQADLLESPQFEEETSMQKFKRRLKEEPLIPLGCAATCYALYRAYRSGKAKDSVEMNRMFRARIYAQFFTLLAVVAGGMYYKTERKQRREFERKVEERKAQEKRDAWLRELEAREKEDKGWRERHAAVSEAANNPVGVSAVVAGKKEEEEKGVDGNVNQAPQEEGGVKRGTGILDAVKALVRGKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKY0</accession>
    <name>B8MKY0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSTA_048370</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485349.1">
        <property type="nucleotide sequence ID" value="XM_002485304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKY0"/>
    <dbReference type="FunCoup" id="B8MKY0">
        <property type="interactions" value="659"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MKY0"/>
    <dbReference type="GeneID" id="8107019"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_048370"/>
    <dbReference type="eggNOG" id="KOG0591">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="InParanoid" id="B8MKY0"/>
    <dbReference type="OMA" id="AYFERDH"/>
    <dbReference type="OrthoDB" id="10250725at2759"/>
    <dbReference type="PhylomeDB" id="B8MKY0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
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    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="12"/>
            <end position="296"/>
        </location>
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        <location>
            <begin position="397"/>
            <end position="467"/>
        </location>
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            <begin position="487"/>
            <end position="530"/>
        </location>
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            <begin position="549"/>
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        </location>
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        <location>
            <begin position="683"/>
            <end position="730"/>
        </location>
    </feature>
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        <location>
            <begin position="298"/>
            <end position="343"/>
        </location>
    </feature>
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        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="432"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="570"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="600"/>
            <end position="614"/>
        </location>
    </feature>
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        <location>
            <begin position="633"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="687"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED15396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="730" mass="81679" checksum="5C227E2DEBD70AEA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>B8ML00</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">TSTA_048560</name>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_048560"/>
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    <dbReference type="InParanoid" id="B8ML00"/>
    <dbReference type="PhylomeDB" id="B8ML00"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED15416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="57" mass="6107" checksum="1C446BF3C35180D5" modified="2009-03-03" version="1">MNVTSIFGRIILGILFDKSTPVGGVVLNDHGHTSLWIFFGALVAASEGVWASLHTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8ML24</accession>
    <name>B8ML24_TALSN</name>
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        <submittedName>
            <fullName evidence="8">DUF726 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_048800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
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        <property type="protein sequence ID" value="EED15440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485393.1">
        <property type="nucleotide sequence ID" value="XM_002485348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ML24"/>
    <dbReference type="ESTHER" id="talsn-b8ml24">
        <property type="family name" value="Duf_726"/>
    </dbReference>
    <dbReference type="GeneID" id="8105663"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_048800"/>
    <dbReference type="eggNOG" id="KOG2385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007407_1_0_1"/>
    <dbReference type="InParanoid" id="B8ML24"/>
    <dbReference type="OMA" id="FAFIPIR"/>
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    <dbReference type="PhylomeDB" id="B8ML24"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF22">
        <property type="entry name" value="DUF726 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G12860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="124"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="605"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="605"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED15440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="747" mass="82296" checksum="F33CB7AA3215FC09" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLI9</accession>
    <name>B8MLI9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable E3 ubiquitin ligase complex SCF subunit sconB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Sulfur controller B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Sulfur metabolite repression control protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_049590</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the SCF(sconB) E3 ubiquitin ligase complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485475.1">
        <property type="nucleotide sequence ID" value="XM_002485430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLI9"/>
    <dbReference type="STRING" id="441959.B8MLI9"/>
    <dbReference type="GeneID" id="8102120"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_049590"/>
    <dbReference type="eggNOG" id="KOG0274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_103_2_1"/>
    <dbReference type="InParanoid" id="B8MLI9"/>
    <dbReference type="OMA" id="AMVPWED"/>
    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="PhylomeDB" id="B8MLI9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051075">
        <property type="entry name" value="SCF_subunit_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872">
        <property type="entry name" value="UBIQUITIN LIGASE SPECIFICITY FACTOR/HREP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872:SF9">
        <property type="entry name" value="UBIQUITIN-BINDING SDF UBIQUITIN LIGASE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6 11" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="13">
        <location>
            <begin position="168"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="367"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="407"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="448"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="488"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="528"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="568"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="240"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="658"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED15522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="708" mass="78195" checksum="B4F5690037015BB0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLZ1</accession>
    <name>B8MLZ1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Monooxygenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_097590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485741.1">
        <property type="nucleotide sequence ID" value="XM_002485696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLZ1"/>
    <dbReference type="STRING" id="441959.B8MLZ1"/>
    <dbReference type="GeneID" id="8108398"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_097590"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_4_0_1"/>
    <dbReference type="InParanoid" id="B8MLZ1"/>
    <dbReference type="OMA" id="NEMSQDL"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="PhylomeDB" id="B8MLZ1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972:SF1">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972">
        <property type="entry name" value="MONOOXYGENASE ASQM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="17"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED13503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="416" mass="46966" checksum="97F1F92133C65DD5" modified="2009-03-03" version="1">MGFLRPPSIPHIMPKNIAIVGAGPSGLTLAALLQHHSIPFTIYEREKSTSSRFQGGSLDLHPDSGQRALFEAGLQQQFNKYARYFDQDYRFGDKHAVTWLNHQATPEADGRPEIDRAMLRKILIESLDPMHIKWDHCVSAVVPMDDGRVKIVFDSQPEPVVTDLLVGADGTWSRVRPLLTTWKPEYTGLTVIDCRISDLNKRFPEIGQFVGRGTYFCLSEGSGIFMQRNGDGSLRVYPCLRVEETWATSDPSFDWNDQKKMTELLINSFFSTWDPRLQDVIRNVDSSMTPRAQYRMPLGLRYDHRPGLTLIGDSLHVMSWFAGEGANLAMLDALDLFHELRAHPEDLDFAVRNYESTVVASGRADVTNEMSQDLLVKAMSDDSPRAYIEGMAKAMDDWFADGKLLDGMDREALFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8MM43</accession>
    <name>B8MM43_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T1</fullName>
            <ecNumber evidence="2">4.6.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_098120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[RNA] containing guanosine + H2O = an [RNA fragment]-3'-guanosine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA fragment].</text>
            <dbReference type="EC" id="4.6.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease N1/T1 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.24" evidence="2"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485793.1">
        <property type="nucleotide sequence ID" value="XM_002485748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MM43"/>
    <dbReference type="STRING" id="441959.B8MM43"/>
    <dbReference type="GeneID" id="8108451"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_098120"/>
    <dbReference type="eggNOG" id="ENOG502SA4T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111658_1_0_1"/>
    <dbReference type="InParanoid" id="B8MM43"/>
    <dbReference type="OMA" id="ACAYTCG"/>
    <dbReference type="OrthoDB" id="5425539at2759"/>
    <dbReference type="PhylomeDB" id="B8MM43"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046589">
        <property type="term" value="F:ribonuclease T1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00606">
        <property type="entry name" value="fungal_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104:SF1">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED13555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="131" mass="14366" checksum="69D7263EEE2D71D7" modified="2009-03-03" version="1">MQFTKVAAATFFFFSSIYAAPLQTRASCIETCGSTCYWQSDIDAALNQGYSLLQSGETDNNYPHQYRDDEGFDFPVSGPYYEYPILSSYKVYTGGSPGADRVIFNSDGDFAGLITHTGSSNYDGFVQCNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
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            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    </dbReference>
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            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="SMP" evidence="2">
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            <begin position="123"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED13659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="176" mass="18365" checksum="8B5A7F6EB92A2973" modified="2009-03-03" version="1">MSYQNIPSVNEIKRAAAAGQRFTPEDVSSIAQAESELTGGGPVKGGPAATAHSLSSKQMNFDARLDELSHKPPSHITQEDARQLQSAEGRAFNAPPGVASVSAQVRSIADRNEALGLPAVADPGPVYVTKEEASEAQSVEAMHTGGMVPKGSYAAQMQSAADKREAAINGVTWLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMG8</accession>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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    <dbReference type="PhylomeDB" id="B8MMG8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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            <end position="102"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="567"/>
        </location>
    </feature>
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            <end position="291"/>
        </location>
    </feature>
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        <location>
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            <end position="317"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="587"/>
        </location>
    </feature>
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        <location>
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            <end position="666"/>
        </location>
    </feature>
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        <location>
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            <end position="685"/>
        </location>
    </feature>
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            <end position="766"/>
        </location>
    </feature>
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        <location>
            <begin position="825"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED13722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="838" mass="92329" checksum="EAFA8E7AEF4DDF20" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMG9</accession>
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        <submittedName>
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        </submittedName>
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        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SCO1/2 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="8105416"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_099730"/>
    <dbReference type="eggNOG" id="KOG2792">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050131_0_2_1"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005743">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Blast:Protein SCO1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR017276">
        <property type="entry name" value="Synth_of_cyt-c-oxidase_Sco1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
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    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF5">
        <property type="entry name" value="AT19154P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037736">
        <property type="entry name" value="SCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="125"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
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        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="163"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED13723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="302" mass="33905" checksum="C428E2F521219BE4" modified="2009-03-03" version="1">MASSLTSLTQSMGRTGRLYARASPKLCSSSSSYLSRSSISQVATIRYQAQSVRNMTSRNGLRSFSTTSARPAKTVQQMKSRQHTGPFSWKAALLFVLTGAGMIIYFRVEKARLERKRITEMSKGVGKPKVGGPFVLKDLDGKEFTAEDLKGKYSFVYFGFTHCPDICPDELDKMAAIIDKVKEASNGAEVMRPVFITCDPARDTPEVLKTYLAEFHPDIIGLTGTYEQVKQVCKAYRVYFSTPENVKSGEDYLVDHSIYFYLMDPEGDFVECVGRQDTPESATRLIMDHVQDWKREGKKLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMP9</accession>
    <name>B8MMP9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_098730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485854.1">
        <property type="nucleotide sequence ID" value="XM_002485809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMP9"/>
    <dbReference type="GeneID" id="8099701"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_098730"/>
    <dbReference type="HOGENOM" id="CLU_022446_0_0_1"/>
    <dbReference type="InParanoid" id="B8MMP9"/>
    <dbReference type="OrthoDB" id="4224428at2759"/>
    <dbReference type="PhylomeDB" id="B8MMP9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="737" mass="83435" checksum="90C4EC4891B30C41" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MP60</accession>
    <name>B8MP60_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nuclear envelope protein Brr6, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_105110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486537.1">
        <property type="nucleotide sequence ID" value="XM_002486492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MP60"/>
    <dbReference type="STRING" id="441959.B8MP60"/>
    <dbReference type="GeneID" id="8098732"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_105110"/>
    <dbReference type="eggNOG" id="KOG4503">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040960_0_0_1"/>
    <dbReference type="InParanoid" id="B8MP60"/>
    <dbReference type="OMA" id="HPHIPRI"/>
    <dbReference type="OrthoDB" id="5961at2759"/>
    <dbReference type="PhylomeDB" id="B8MP60"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040202">
        <property type="entry name" value="Brl1/Brr6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018767">
        <property type="entry name" value="Brl1/Brr6_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136:SF1">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10104">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01042">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0261">Viral envelope protein</keyword>
    <keyword evidence="4" id="KW-0946">Virion</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Brl1/Brr6" evidence="3">
        <location>
            <begin position="228"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED14299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="474" mass="54823" checksum="467FB9A9F93CAC8B" modified="2009-03-03" version="1">MERRTAESPMDFEWQTRAPGDITSPFYQLGLQHDNQKKSFVFDSPLKKQSAPTQSFNFSQPSPQRNGSPNRPDAIFGKSSFQTPRKFDLDFSSGAENMSSPENADNEGTPESIQVNKNERRNSLFRFYGRFAPSPGRGEIPRVTNHKTDHARRIHKRKIRDRDINRHLRRDSDYDSDRPSSREEAQQLSKFETKKFEQTPSPSLPPQGSTWAHFFAFLDEHPNLPAILSYWLQLVWNLVLFSLVTWVVVSFVLTIKQDIDHAADAKRNDILTEISTCKEFYIQNSCNLASRPPALNEVCNNWERCMDQDPNRVARATVSVQTISAIITGFVDAISFKAFSYFLLTITTITIASNWSFIALRHQYTKKEDRRPYPNSQHPQGQPSYQHRQAPPVSYAADGNQYPLEYPKTPGRGEESPSRRQRNYQDDDEDNDRQSRRLLLENTPSRDMAFVTGRSRERELHARTPSPSKRERWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPM1</accession>
    <name>B8MPM1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal specific transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_106700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486698.1">
        <property type="nucleotide sequence ID" value="XM_002486653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPM1"/>
    <dbReference type="STRING" id="441959.B8MPM1"/>
    <dbReference type="GeneID" id="8103570"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_106700"/>
    <dbReference type="eggNOG" id="ENOG502RBGV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008511_3_1_1"/>
    <dbReference type="InParanoid" id="B8MPM1"/>
    <dbReference type="OMA" id="CLMLMNR"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="PhylomeDB" id="B8MPM1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="667"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="693"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED14460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="703" mass="80064" checksum="122405625F190AA6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPW0</accession>
    <name>B8MPW0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">UDP-N-acetylglucosamine transferase subunit ALG14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Asparagine-linked glycosylation protein 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ALG14</name>
        <name evidence="12" type="ORF">TSTA_052890</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Heterodimer with ALG13 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ALG14 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486879.1">
        <property type="nucleotide sequence ID" value="XM_002486834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPW0"/>
    <dbReference type="FunCoup" id="B8MPW0">
        <property type="interactions" value="301"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MPW0"/>
    <dbReference type="GeneID" id="8098238"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_052890"/>
    <dbReference type="eggNOG" id="KOG3339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064541_0_0_1"/>
    <dbReference type="InParanoid" id="B8MPW0"/>
    <dbReference type="OMA" id="FSMLRRM"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="PhylomeDB" id="B8MPW0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013969">
        <property type="entry name" value="Oligosacch_biosynth_Alg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154:SF4">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08660">
        <property type="entry name" value="Alg14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED12768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="269" mass="29887" checksum="03C7CB0A7D8F75D7" modified="2009-03-03" version="1">MPALTIAAFAVLSLFLVTFALIISLHLILSSSQHSAVPKLRRRGTPTHVLIVLGSGGHTAEMLSMLRRMPLDPNTYTFRTYLVTSGDSFSASKAAEFEATLHAQYKDSKHTQNQDYEIITVPRARRVHQSYLTAPFSTIQCFWACLQVLRGRHSDQRSSKRDLASPYPDLILTNGPATAVCVVLGAKLLRFWIALSALLLLKSSQTSSPPTSALRTVFIESWARVTTLSLSGKILLPFVDRFLVQWPNLEGKQAWKGMRKAEYVGTIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQH5</accession>
    <name>B8MQH5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_058660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487488.1">
        <property type="nucleotide sequence ID" value="XM_002487443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQH5"/>
    <dbReference type="STRING" id="441959.B8MQH5"/>
    <dbReference type="GeneID" id="8106468"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_058660"/>
    <dbReference type="eggNOG" id="ENOG502SHB3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006329_3_1_1"/>
    <dbReference type="InParanoid" id="B8MQH5"/>
    <dbReference type="OMA" id="VCMMVME"/>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="PhylomeDB" id="B8MQH5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052761">
        <property type="entry name" value="Fungal_Detox/Toxin_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="18"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED13377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="720" mass="80919" checksum="5A3752B8B5DDB9D3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQU1</accession>
    <name>B8MQU1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_052950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486887.1">
        <property type="nucleotide sequence ID" value="XM_002486842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQU1"/>
    <dbReference type="STRING" id="441959.B8MQU1"/>
    <dbReference type="GeneID" id="8098244"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_052950"/>
    <dbReference type="eggNOG" id="ENOG502SHS7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8MQU1"/>
    <dbReference type="OMA" id="TCWAMIE"/>
    <dbReference type="OrthoDB" id="4682787at2759"/>
    <dbReference type="PhylomeDB" id="B8MQU1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="53"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED12776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="384" mass="42406" checksum="B137E89AC57A804F" modified="2009-03-03" version="1">MNFISRCIYSSQIFIFAVEQTTNIGKEMVSTLGKAVLAIAWVFNGVAALVVAARYYARIKILKRFTIDDALILLTLLLAVGNSVFLTISVHWGLGTHMAALSDIQIQNTVKWVFLCEFFSILSPGIGRIAYAFLLLGLVPPVQWRTRFLWSIIAIQFVVDIVTIIISFAQCRPLSTFWNHDVSGTCWSPSVQQDTGFFQGSVCSAVDLTLAVFPASMFWNLNMERKKKIFLSCLMGLGVFAMTASIIKTIELRAITAAADLTYAMAQLAIWWTLEANLVLIATSIPTLGPIIRRQHRHPSPVPDGSSRSSKGGGAQATRPWHALFYAKRSKTERGSSEDLWPGVPKAYALEESVSREQKRGIKKTTTIGVGYEDVDAAPLGTIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B8MR76</accession>
    <name>B8MR76_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ABC multidrug transporter MDR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_054810</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487082.1">
        <property type="nucleotide sequence ID" value="XM_002487037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MR76"/>
    <dbReference type="STRING" id="441959.B8MR76"/>
    <dbReference type="GeneID" id="8100488"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_054810"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_17_2_1"/>
    <dbReference type="InParanoid" id="B8MR76"/>
    <dbReference type="OMA" id="CFTEGFC"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="PhylomeDB" id="B8MR76"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="619"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="696"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="722"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="65"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="235"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="574"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED12971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="974" mass="107420" checksum="B04B2496BFCDCD82" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRQ4</accession>
    <name>B8MRQ4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lactoylglutathione lyase (Glo1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_057070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487322.1">
        <property type="nucleotide sequence ID" value="XM_002487277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRQ4"/>
    <dbReference type="STRING" id="441959.B8MRQ4"/>
    <dbReference type="GeneID" id="8109938"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_057070"/>
    <dbReference type="eggNOG" id="KOG2944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_1_0_1"/>
    <dbReference type="InParanoid" id="B8MRQ4"/>
    <dbReference type="OMA" id="IGYKLNH"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="PhylomeDB" id="B8MRQ4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF19">
        <property type="entry name" value="LYASE (GLO1), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00935">
        <property type="entry name" value="GLYOXALASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="3">
        <location>
            <begin position="40"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED13211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="224" mass="24758" checksum="9F731FB3FEDC1958" modified="2009-03-03" version="1">MTPVPNSFPSPLPPLPVGRHLPGGHGLDPAVSPNTTEGFHLNHLMLRIHDPSESLHFYIDLMGLRTIFAMNTGPCSVYYLGHPQTEAERAHPKLYAQNTVPNDVLTKTKGLIELVHIHGTEKLSKEEYKLQSGNVAPWLGFGHVGFTVPDVPAALQRLKENGVNVLKDVGYAEREHVPITEWESSELGAGVGELHEGYKHVLSQIGFVEDPNGYWIELVPQNMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MS20</accession>
    <name>B8MS20_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_002640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487852.1">
        <property type="nucleotide sequence ID" value="XM_002487807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MS20"/>
    <dbReference type="STRING" id="441959.B8MS20"/>
    <dbReference type="GeneID" id="8102875"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_002640"/>
    <dbReference type="eggNOG" id="ENOG502S12R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044876_3_3_1"/>
    <dbReference type="InParanoid" id="B8MS20"/>
    <dbReference type="OMA" id="PWGLWDE"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="PhylomeDB" id="B8MS20"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="32"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED12198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="328" mass="34788" checksum="21917BD9C3F58DF9" modified="2009-03-03" version="1">MLVAQYLLGSTVSNQICTSSISKLAMSGSVIKNVAVVGASGSVGRFVVKALLEENFQVTGVTRETSKATLPEGVRHVKTDYSAASLQEAFKGQDAVVGAIGSITPGEALTLQKPLIDAAIAAGVKVFFPSEYGIDTSDHASKDYIPFLVDKIETLDYIKTKQDKISWTAIVSGGMFDWGLDIPGFGGLNIPAGTATIFDGGNIPYEATTLAQVGRAIAKSLKKPELTKNQYVYVNSFTVTQNQVLAAIEKASGKKFKTSESTVEELFSGGAEQWKSGNPMGVLAMIAGAVYGKGGLAQFSTKQGLWNEKLGLPQEDLNEVVKAYLARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSP8</accession>
    <name>B8MSP8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytokinesis protein SepA/Bni1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_005430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the formin homology family. BNI1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488160.1">
        <property type="nucleotide sequence ID" value="XM_002488115.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B8MSP8">
        <property type="interactions" value="499"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MSP8"/>
    <dbReference type="GeneID" id="8105517"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_005430"/>
    <dbReference type="eggNOG" id="KOG1922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001313_1_0_1"/>
    <dbReference type="InParanoid" id="B8MSP8"/>
    <dbReference type="OMA" id="NHYWKAR"/>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="PhylomeDB" id="B8MSP8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.150:FF:000003">
        <property type="entry name" value="Cytokinesis protein SepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.2220:FF:000006">
        <property type="entry name" value="Cytokinesis protein sepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000291">
        <property type="entry name" value="Cytokinesis protein sepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.30.50:FF:000001">
        <property type="entry name" value="Cytokinesis sepA protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051661">
        <property type="entry name" value="Actin_filament_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014767">
        <property type="entry name" value="DAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102:SF2">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51231">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="6">
        <location>
            <begin position="289"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="7">
        <location>
            <begin position="1138"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="domain" description="DAD" evidence="5">
        <location>
            <begin position="1576"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="135"/>
            <end position="188"/>
        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="PROSITE" id="PS51444"/>
        </source>
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    <sequence length="1793" mass="198865" checksum="A7AF2DC59095B7BD" modified="2009-03-03" version="1"> </sequence>
</entry>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="HOGENOM" id="CLU_1758601_0_0_1"/>
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    <dbReference type="PhylomeDB" id="B8MT04"/>
    <dbReference type="Proteomes" id="UP000001745">
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    </dbReference>
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            <dbReference type="EMBL" id="EED12029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="15126" checksum="53CE79A9BD15071C" modified="2009-03-03" version="1">MSNKNPLPTGSSSIGMHLSEEAIARTHILSLINRYASFARGIPDQQNEIAVLFEPNATILLPDGRELSPLEIGKITENNTPKLLRHHVTTVDVQWDDVVVRSGDGRCPFKRKVIVVDGMDAEGWLSQTVAEGVEAVAR</sequence>
</entry>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED12649.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="621" mass="69159" checksum="75620C9A8D50FFED" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8MU27</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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    <dbReference type="eggNOG" id="ENOG502SY3V">
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    </dbReference>
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    <dbReference type="InParanoid" id="B8MU27"/>
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    <dbReference type="PhylomeDB" id="B8MU27"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED12660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="62" mass="6833" checksum="6E8C77053929E8FC" modified="2009-03-03" version="1">MPPKRVVVQSGRRDQEQAGLFGATYKEITNPENATIVRSIVIFSAAVAFFHSSLSEFLIPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B8MU57</accession>
    <name>B8MU57_TALSN</name>
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        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
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    </protein>
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        <name evidence="1" type="ORF">TSTA_109540</name>
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    <organism evidence="1 2">
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        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
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            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488531.1">
        <property type="nucleotide sequence ID" value="XM_002488486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MU57"/>
    <dbReference type="GeneID" id="8107186"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109540"/>
    <dbReference type="HOGENOM" id="CLU_1143192_0_0_1"/>
    <dbReference type="InParanoid" id="B8MU57"/>
    <dbReference type="OrthoDB" id="5374120at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="29251" checksum="BD80E7FFD1E71D15" modified="2009-03-03" version="1">MSQFEKIPPELRLLIYRELFSVKEVIHVGTPKSKMSRYPNILQSNRLIYGEATEILYTETLLILHLHPDNYPEIGFRHNPFEDERWEKGYAWPSKDLVAVQYGGEELKGSMEPHVFARFRRVLICLQSTLEARYVASWVNPDISIVEDIKSTVERHPHPLAFIGKLLRRSFNLQLAGLHLGLVLDGHKLENVNVQDLIKRFNKCSEQIMNNTGLLHGCEKIKASLHATTQNPEQKCSLLSTPYSDLESHLSQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MU63</accession>
    <name>B8MU63_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_109630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488539.1">
        <property type="nucleotide sequence ID" value="XM_002488494.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MU63"/>
    <dbReference type="GeneID" id="8107195"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109630"/>
    <dbReference type="eggNOG" id="KOG2029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003640_0_0_1"/>
    <dbReference type="InParanoid" id="B8MU63"/>
    <dbReference type="OMA" id="SPWSPDI"/>
    <dbReference type="OrthoDB" id="4224977at2759"/>
    <dbReference type="PhylomeDB" id="B8MU63"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026003">
        <property type="entry name" value="Cohesin_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055496">
        <property type="entry name" value="DUF7068"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12765">
        <property type="entry name" value="Cohesin_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23238">
        <property type="entry name" value="DUF7068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="1">
        <location>
            <begin position="410"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1584" mass="181108" checksum="0FD38A2FDDF2FC95" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUT2</accession>
    <name>B8MUT2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HEAT repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_110000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488576.1">
        <property type="nucleotide sequence ID" value="XM_002488531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUT2"/>
    <dbReference type="STRING" id="441959.B8MUT2"/>
    <dbReference type="GeneID" id="8107232"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_110000"/>
    <dbReference type="eggNOG" id="KOG2029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_674556_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUT2"/>
    <dbReference type="OrthoDB" id="427518at2759"/>
    <dbReference type="PhylomeDB" id="B8MUT2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="38803" checksum="25D0CD52A8270E92" modified="2009-03-03" version="1">MEDKPHDFLGPAHQRILMHCFGEVPPNSGLENLRTLIEAQLKQWALFEYKLRGEMTLCREMEFPDNVLISMMNEGEPEDVKNAILQALRHRSNFSVCLVNLIAYLLGQNVSSDLEWFAINALGRQTSLPDNILQAIVHRLEHSEWRTAINVLGKQTVLSDDILQAIVRRLEDSNGYVRQSANYALNKQITLSDNILQAIVRQLEHSEEDVRQSAIDALDKQTSLSDDILQSIVLVLSKNTSSTDSESVSMLLKQDNLYDSFQNFDVETLRSLYRLLVQQSFSEHLTCYMQDKTFYINMPDRQKRVSLVQSKDVFLDAFRDEAVALGRPLTASTDNLRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MV78</accession>
    <name>B8MV78_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_008300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962662">
        <property type="protein sequence ID" value="EED11534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488715.1">
        <property type="nucleotide sequence ID" value="XM_002488670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MV78"/>
    <dbReference type="STRING" id="441959.B8MV78"/>
    <dbReference type="GeneID" id="8110163"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_008300"/>
    <dbReference type="eggNOG" id="ENOG502RVV8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_1_1_1"/>
    <dbReference type="InParanoid" id="B8MV78"/>
    <dbReference type="OMA" id="AHWDHVF"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="PhylomeDB" id="B8MV78"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF2">
        <property type="entry name" value="102 KBASES UNSTABLE REGION: FROM 1 TO 119443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED11534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="34789" checksum="D85E5D863DE89337" modified="2009-03-03" version="1">MSYKDNNPLPSLKSNNVVISIAAFETGWMKIDASLAIAGLKGEFNATSWRFFMQHAPSNTKFWFDLGVAHDLSLYPPQIQRVQHKVFFTTPAKRDPAQDVISVGVDPKDVKYIFVRHDGNYNGIVISMFFTSDFFPNAKVLCHEDTLKWTSTTWPTDPEGGFDGRIWNKEELVLPIDGIPSPATAPEKWQTLGPFKNAHDFFGDGSFWLIDAPGHCLGNMAALARIKRKDGVIKWAFLGGDYFHTPMFISYPDAPFGKGVKVTSTDSFHEDEEQAREIIRQAAELKRGEGENALIWLAHTDVLEDAWNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>H9CNN5</accession>
    <name>H9CNN5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">NADH-ubiquinone oxidoreductase chain 4L</fullName>
            <ecNumber evidence="4 16">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSTA_m0530</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="17"/>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="BMC Genomics" volume="13" first="698" last="698">
            <title>Sequencing of mitochondrial genomes of nine Aspergillus and Penicillium species identifies mobile introns and accessory genes as main sources of genome size variability.</title>
            <authorList>
                <person name="Joardar V."/>
                <person name="Abrams N.F."/>
                <person name="Hostetler J."/>
                <person name="Paukstelis P.J."/>
                <person name="Pakala S."/>
                <person name="Pakala S.B."/>
                <person name="Zafar N."/>
                <person name="Abolude O.O."/>
                <person name="Payne G."/>
                <person name="Andrianopoulos A."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="23234273"/>
            <dbReference type="DOI" id="10.1186/1471-2164-13-698"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Mitochondrion inner membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the complex I subunit 4L family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="4 16"/>
    <dbReference type="EMBL" id="JQ354994">
        <property type="protein sequence ID" value="AFD95929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9CNN5"/>
    <dbReference type="SMR" id="H9CNN5"/>
    <dbReference type="STRING" id="441959.H9CNN5"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_m0530"/>
    <dbReference type="InParanoid" id="H9CNN5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030964">
        <property type="term" value="C:NADH dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3510:FF:000004">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase chain 4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001133">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chain4L/K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004320">
        <property type="entry name" value="PRK05715.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434:SF16">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT ND4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 16 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-0520">NAD</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9 16" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 16" id="KW-0813">Transport</keyword>
    <keyword evidence="12 16" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AFD95929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="89" mass="9952" checksum="1E6DD381B4564054" modified="2012-05-16" version="1">MNFSIFLFLIGILGFVLNRKNIILMLISIEIMLLAITFLILISSFNFDDILGQTFAIYIITIAGAESAIGLGILVAYYRLRGSISIQYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8LSX5</accession>
    <name>B8LSX5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor (ArcA), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_064390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340358.1">
        <property type="nucleotide sequence ID" value="XM_002340317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LSX5"/>
    <dbReference type="STRING" id="441959.B8LSX5"/>
    <dbReference type="GeneID" id="8104398"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_064390"/>
    <dbReference type="eggNOG" id="ENOG502QT0Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008719_3_1_1"/>
    <dbReference type="InParanoid" id="B8LSX5"/>
    <dbReference type="OMA" id="KECRWNA"/>
    <dbReference type="OrthoDB" id="4078573at2759"/>
    <dbReference type="PhylomeDB" id="B8LSX5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF40">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="599"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="607"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED22971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="672" mass="75962" checksum="B96754C64B81CC88" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8LT80</accession>
    <name>B8LT80_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTPase activating protein (Gyp1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_070020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340975.1">
        <property type="nucleotide sequence ID" value="XM_002340934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LT80"/>
    <dbReference type="FunCoup" id="B8LT80">
        <property type="interactions" value="1076"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LT80"/>
    <dbReference type="GeneID" id="8102344"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_070020"/>
    <dbReference type="eggNOG" id="KOG1092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018687_4_0_1"/>
    <dbReference type="InParanoid" id="B8LT80"/>
    <dbReference type="OMA" id="MYPTARK"/>
    <dbReference type="OrthoDB" id="26371at2759"/>
    <dbReference type="PhylomeDB" id="B8LT80"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000007">
        <property type="entry name" value="TBC1 domain family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000037">
        <property type="entry name" value="TBC1 domain family member 22A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000001">
        <property type="entry name" value="TBC1 domain family member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF26">
        <property type="entry name" value="LD44506P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="267"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED23588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="589" mass="66545" checksum="2AC9889773AD7332" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTF5</accession>
    <name>B8LTF5_TALSN</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_064940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002340379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTF5"/>
    <dbReference type="STRING" id="441959.B8LTF5"/>
    <dbReference type="GeneID" id="8105383"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_064940"/>
    <dbReference type="eggNOG" id="ENOG502SUMK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023947_0_0_1"/>
    <dbReference type="InParanoid" id="B8LTF5"/>
    <dbReference type="OMA" id="YQSLQYY"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="PhylomeDB" id="B8LTF5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF23">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="74"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED23033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="711" mass="80348" checksum="5F6F8D97FEC3DFC5" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTH5</accession>
    <name>B8LTH5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C6 finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_065130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340440.1">
        <property type="nucleotide sequence ID" value="XM_002340399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTH5"/>
    <dbReference type="STRING" id="441959.B8LTH5"/>
    <dbReference type="GeneID" id="8106052"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_065130"/>
    <dbReference type="eggNOG" id="ENOG502SQCY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1367050_0_0_1"/>
    <dbReference type="InParanoid" id="B8LTH5"/>
    <dbReference type="OrthoDB" id="5130013at2759"/>
    <dbReference type="PhylomeDB" id="B8LTH5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED23053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="23288" checksum="58740D6FE0DC31F3" modified="2009-03-03" version="1">MLYSLSPTSDKAEIIGSLGFSLELLDVIHRINFLRDNLPRRTYTTEFDDLEAQLLRLTQHANIEKFSKDQDQIARILSTAEFYRIAALIYLLRVIPGPENAKRRSSYVIQGFEVLRSLPICTSPWPLFVLACETQSDEQRIEILHTLDQMDQNRKIGNVFVIRNIIETLWKQQDLQADVDNSKFKWWETGALNSNTPWFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTL3</accession>
    <name>B8LTL3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Salicylate hydroxylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_065470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340479.1">
        <property type="nucleotide sequence ID" value="XM_002340438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTL3"/>
    <dbReference type="STRING" id="441959.B8LTL3"/>
    <dbReference type="GeneID" id="8101058"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_065470"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8LTL3"/>
    <dbReference type="OMA" id="IAGYCPT"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="PhylomeDB" id="B8LTL3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000115">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF307">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="15"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED23092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="433" mass="47882" checksum="899AAD79F9BC6312" modified="2009-03-03" version="1">MHAQKGEQAKVPLNAIVVGGGIGGIATALSLGRRGHNVVILESAPKLMEVGAGIQVSPNMGRLLDRWGVAYREKATLLQQIDIRRWQDGSLLACIPCNPAHGDQLTIHRADLHNALIEKALSLPNVQLLVNSHVVDVNFDKTEVILADGRVISGDVVLAADGIKSNIRPKILNDNTIKVQPTGDAAYRITLSREEMLAHPVLRDMIDQSRATRWIGPGCHIVAYPLRNHELFNVVLVHPDRGTVDDMWTIKGSKKDMIDEYAGWDERVTQIIANVQDDAVMEWKLNLYPPLRTWTKGSIALLGDACHPMLPYVAQGAAQAVEDAGALGAILSSISSKLDIPAALQAYQSSRKERAEQVQQSGKLNRIALHLPDGPEQLQRDEMFRLAMQGNSESPDRWIDEKTRKILWEHDAEEAALKTFQEYQNKHSRVANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUD0</accession>
    <name>B8LUD0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal specific transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_071060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341090.1">
        <property type="nucleotide sequence ID" value="XM_002341049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUD0"/>
    <dbReference type="STRING" id="441959.B8LUD0"/>
    <dbReference type="GeneID" id="8107604"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_071060"/>
    <dbReference type="eggNOG" id="ENOG502QVV0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008471_0_0_1"/>
    <dbReference type="InParanoid" id="B8LUD0"/>
    <dbReference type="OrthoDB" id="5297881at2759"/>
    <dbReference type="PhylomeDB" id="B8LUD0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="83"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="697"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="779"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="922"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="706"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="780"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="922"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED23703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1044" mass="116110" checksum="54385AF368E0AE58" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUD6</accession>
    <name>B8LUD6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_071120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341096.1">
        <property type="nucleotide sequence ID" value="XM_002341055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUD6"/>
    <dbReference type="STRING" id="441959.B8LUD6"/>
    <dbReference type="GeneID" id="8107621"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_071120"/>
    <dbReference type="eggNOG" id="KOG4253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044758_0_0_1"/>
    <dbReference type="InParanoid" id="B8LUD6"/>
    <dbReference type="OMA" id="YFYYALP"/>
    <dbReference type="OrthoDB" id="4218123at2759"/>
    <dbReference type="PhylomeDB" id="B8LUD6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470:SF1">
        <property type="entry name" value="CHORISMATE SYNTHASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="384" mass="42257" checksum="122833F7A0696BEE" modified="2009-03-03" version="1">MANGIISLLNWGNIKSLLLFFGPILLLRIINYYRAFRVQLAHRPPPRPILTEANRALNLLFGVIVVFLILSVPSNPYAPPPNIFTQTGSRINTPTDIIFARLARHRPDNELTDYDKLLRGNLTSIAQKKIYLRFGPEALLSCQFCNPEDPFSYLLFYLPLNTLVPHLIHLLTLGVVTSAPFAGTEAARWRSWFTFAALGLAGLDCYIMSSYDPIAAASPAVRAGQVPPLSLFTTMNMIRFLSLTVFDVVCAALIYISATHRFFYSPPSPNEQINHVIAAATAALNSANSKLHSLSVTRNAVVRDPSLKARDDWYWRAAVAMEGSSDANSSGDGSIWEEEEVVRAMSRVMNGRGRSRGLDMAQLGINAGEFVDKITAGLESGASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUT6</accession>
    <name>B8LUT6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein ERB1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic ribosome biogenesis protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ERB1</name>
        <name evidence="10" type="ORF">TSTA_073330</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat BOP1/ERB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341330.1">
        <property type="nucleotide sequence ID" value="XM_002341289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUT6"/>
    <dbReference type="FunCoup" id="B8LUT6">
        <property type="interactions" value="1049"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LUT6"/>
    <dbReference type="GeneID" id="8105601"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_073330"/>
    <dbReference type="eggNOG" id="KOG0650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011390_0_1_1"/>
    <dbReference type="InParanoid" id="B8LUT6"/>
    <dbReference type="OMA" id="MRPAKGE"/>
    <dbReference type="OrthoDB" id="5571054at2759"/>
    <dbReference type="PhylomeDB" id="B8LUT6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000061">
        <property type="entry name" value="Ribosome biogenesis protein BOP1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03027">
        <property type="entry name" value="BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="9">
        <location>
            <begin position="146"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="413"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="309"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="309"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED23943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="777" mass="87152" checksum="830C93006EE0649E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8LV39</accession>
    <name>B8LV39_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_061480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LovG family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340047.1">
        <property type="nucleotide sequence ID" value="XM_002340006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LV39"/>
    <dbReference type="GeneID" id="8106640"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_061480"/>
    <dbReference type="eggNOG" id="KOG2551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051938_0_0_1"/>
    <dbReference type="InParanoid" id="B8LV39"/>
    <dbReference type="OMA" id="MDARNQE"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="PhylomeDB" id="B8LV39"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF3">
        <property type="entry name" value="ESTERASE DBAE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="61"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED22660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="339" mass="37571" checksum="505F164B65A9C680" modified="2009-03-03" version="1">MGLITPQSPDSLSRFSLADDTNSNCHFCDISHCFHIPFSVNIGIMIVDQPSPVVDQTLHLPRILCLHGGGTNARIFRAQCRIIKRYLSTTFRLVFAEAPFSSDAGPDVTSVYQEFGPFKRWLRSKKSHPKIHPDNAVKAIDDSLKAAMDEDDRLGGRGEWVGLLGFSQGAKMCASLLFRQQVRAERLGLHCTGSNWRFAIILAGRGPLVSLDHHLLMTPAVVAASEASTTALPDECLRGSTEHVLYLPTIHVHGTQDAGLNEHRKLLSQYCEEGTARLMEWEGNHRVPIKTKDAIALVQNIWDIAYETGILTKQLDVEAIVQAEAFQPANVFRPRTILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8LV58</accession>
    <name>B8LV58_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">4-hydroxyphenylpyruvate dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_065630</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="12">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the 4HPPD family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340495.1">
        <property type="nucleotide sequence ID" value="XM_002340454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LV58"/>
    <dbReference type="STRING" id="441959.B8LV58"/>
    <dbReference type="GeneID" id="8105587"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_065630"/>
    <dbReference type="eggNOG" id="KOG0638">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034004_3_1_1"/>
    <dbReference type="InParanoid" id="B8LV58"/>
    <dbReference type="OMA" id="DPFPVKG"/>
    <dbReference type="OrthoDB" id="414569at2759"/>
    <dbReference type="PhylomeDB" id="B8LV58"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000001">
        <property type="entry name" value="4-hydroxyphenylpyruvate dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000020">
        <property type="entry name" value="4-hydroxyphenylpyruvate dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959:SF1">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="VOC" evidence="13">
        <location>
            <begin position="26"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="13">
        <location>
            <begin position="213"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED23108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="415" mass="46630" checksum="7F8C8DB4F3B52DAE" modified="2009-03-03" version="1">MAPSALSDLQSGNLPTTQNALSSYRGYDHVHWYVGNAKQAATFYITRMGFERVAYRGLETGSRSVCSHVVRNGSITFVLTSPLRSPYNTEKLNRLFPGEKEREHVKEIHEHLAKHGDAVKDVAFEVDSVDDVYNAAVQNGAVAVSQPRTLEDENGQVKVATIRTYGDTTHTLIQRRGVASPYTGVFLPGYRDETGSGSSDPIAALLPKVDLKRIDHCVGNQDWDEMEKVCAYYEKVLGFHRFWSVDDKDICTDYSALKSIVMSSPNDIVKMPINEPAHGKKQSQIEEYVDFYDGAGVQHIALLTDDIISAITNLKARGVEFIKVPSTYYDNMWVRLKKAGMMPKEAWEDIKKLDILIDFDEGGYLLQLFTKHLMDRPTVFIEIIQRNNFSGFGAGNFKSLFEAIEREQALRGNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8LV73</accession>
    <name>B8LV73_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_065760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340510.1">
        <property type="nucleotide sequence ID" value="XM_002340469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LV73"/>
    <dbReference type="STRING" id="441959.B8LV73"/>
    <dbReference type="GeneID" id="8107662"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_065760"/>
    <dbReference type="HOGENOM" id="CLU_1571690_0_0_1"/>
    <dbReference type="InParanoid" id="B8LV73"/>
    <dbReference type="OrthoDB" id="5392716at2759"/>
    <dbReference type="PhylomeDB" id="B8LV73"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="1">
        <location>
            <begin position="8"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="170" mass="19826" checksum="39647E20193CBD6D" modified="2009-03-03" version="1">MPAGRPPSQINQYKQEISTSFQNGQSISNITKMLSDEYQITIHPETIRRRLKQWGVSRTNPGPRELEDKIKELYFKQGLRDKEIIRALERDGIKISQSTLTTIWLRIGLQRRVVKPEDIQHTDDIVREAVREQLNTTALKSVYCNSFLKYFKKQIFSLAIYALIKGAKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWA2</accession>
    <name>B8LWA2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_075060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341517.1">
        <property type="nucleotide sequence ID" value="XM_002341476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWA2"/>
    <dbReference type="GeneID" id="8099948"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_075060"/>
    <dbReference type="HOGENOM" id="CLU_1705421_0_0_1"/>
    <dbReference type="InParanoid" id="B8LWA2"/>
    <dbReference type="PhylomeDB" id="B8LWA2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED24130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="154" mass="16737" checksum="F1C3F7F69556B328" modified="2009-03-03" version="1">MACGWYYDSDNSNKEGSSNEAEPSDTDLTEPEDGFASEVDQTDSGAEDSDSTMANSSNTEESGTLSHQVLSIKKLAISKNQRYEGPGDNPTQNLSDIDPDFNMSGNTKKLRSRVIDRWHCESQREVSPLELEQTGGRTPKGICGLAISLSTLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWA5</accession>
    <name>B8LWA5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_075090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341520.1">
        <property type="nucleotide sequence ID" value="XM_002341479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWA5"/>
    <dbReference type="STRING" id="441959.B8LWA5"/>
    <dbReference type="GeneID" id="8106216"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_075090"/>
    <dbReference type="eggNOG" id="ENOG502RHTH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_30_3_1"/>
    <dbReference type="InParanoid" id="B8LWA5"/>
    <dbReference type="OMA" id="PKHPSGQ"/>
    <dbReference type="OrthoDB" id="4509585at2759"/>
    <dbReference type="PhylomeDB" id="B8LWA5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED24133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="200" mass="22800" checksum="4C4CEDBF7F32454E" modified="2009-03-03" version="1">MALEMAQQRIVREAIIFCDSQAAIQAIDGTQKTGQQILGSIAEKWDELRNQGVQVSIHWIPTHQGIEGNERADRAAKEATGWRLIRNIGLQQPLSALKRDLKTLAYKQWEQEWQRNQQGRTLFRIVDKPSKKNIELHARLSRPLSSILTQMWTGNIGLRHFLYQRKIPGIDDGECQCRRGAQTVTHILLSCPKVQGGVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWJ3</accession>
    <name>B8LWJ3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homoserine acetyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_076700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341691.1">
        <property type="nucleotide sequence ID" value="XM_002341650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWJ3"/>
    <dbReference type="STRING" id="441959.B8LWJ3"/>
    <dbReference type="GeneID" id="8105623"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_076700"/>
    <dbReference type="eggNOG" id="ENOG502QVPA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028760_2_0_1"/>
    <dbReference type="InParanoid" id="B8LWJ3"/>
    <dbReference type="OMA" id="KLGDWEL"/>
    <dbReference type="OrthoDB" id="9972683at2759"/>
    <dbReference type="PhylomeDB" id="B8LWJ3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005757">
        <property type="entry name" value="PRK07581.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF15">
        <property type="entry name" value="HOMOSERINE ACETYLTRANSFERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G15350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="71"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED24304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="358" mass="39526" checksum="B41A8C29D1C061F5" modified="2009-03-03" version="1">MASSNSTPDNRDFSLFHLGDFQLESGEVLPQAFLAYKTFGDIKNPAIIHPTSYTAFIHETASVILDSRASLNPSKYFIVVPALFSNGQSTSPSNSPNLRDKFPSITFADNVRAQYLLVTQKLGLTKVKAVVGFSMGGAQAYQWAVQYPDFMDVVVPICASAKNAIHNNVFLEGVKSSLIAARGGISLGIGKGQRYPSNEPWTPQQKEVGLKAFGRVYAGWGLSQAWYRQKLFTKFFGAKDEEEFLQTFWEPWGLKNDPDDLLVMLQTWQLGDISKSPEFGGDLRKALQSIKCRVVVAPVETDLYFPPEDSRFEVENMLPGRGTLAVVPSVWGHWGGGCVDSTADLQFLDEAMAKVFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWP4</accession>
    <name>B8LWP4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL28m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_078030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341828.1">
        <property type="nucleotide sequence ID" value="XM_002341787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWP4"/>
    <dbReference type="STRING" id="441959.B8LWP4"/>
    <dbReference type="GeneID" id="8105658"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_078030"/>
    <dbReference type="eggNOG" id="KOG3278">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064548_0_2_1"/>
    <dbReference type="InParanoid" id="B8LWP4"/>
    <dbReference type="OMA" id="WELRWKV"/>
    <dbReference type="OrthoDB" id="361870at2759"/>
    <dbReference type="PhylomeDB" id="B8LWP4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.40:FF:000003">
        <property type="entry name" value="54S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="entry name" value="Ribosomal protein L28/L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribosomal_bL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="Ribosomal_bL28/bL31-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribosomal_bL28_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL28M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="L28p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="213"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED24441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="247" mass="27806" checksum="CF14CC1C50AC3214" modified="2009-03-03" version="1">MAGIPTRLMTASTSSLNATFRGLSLNTSVPTIKRGFSTSSSLQKVKTIPEHIPPYPYKPNYVYKQADSGLYGGVTISFGNKISKGRNKGKTRRSWKPNVRWKKLPSEALGEEVFVKLTRKALRTIRKCGGLDNYLLCDKPSRLKELGLTGWKLRYRIMQSPSMKKKFAEEREKLGISKSPNTFEEWLKAKQLSGVTFAVEAIEDAREVTKVLEEASTNEETLPEPETLKGSQKQEQAPVEFWGMRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWT5</accession>
    <name>B8LWT5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_079240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341955.1">
        <property type="nucleotide sequence ID" value="XM_002341914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWT5"/>
    <dbReference type="FunCoup" id="B8LWT5">
        <property type="interactions" value="995"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LWT5"/>
    <dbReference type="GeneID" id="8105989"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_079240"/>
    <dbReference type="eggNOG" id="KOG3155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094365_1_0_1"/>
    <dbReference type="InParanoid" id="B8LWT5"/>
    <dbReference type="OMA" id="TPSKWWL"/>
    <dbReference type="OrthoDB" id="200404at2759"/>
    <dbReference type="PhylomeDB" id="B8LWT5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1760.10:FF:000002">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1760.10">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007204">
        <property type="entry name" value="ARPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036753">
        <property type="entry name" value="ARPC3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12391">
        <property type="entry name" value="ARP2/3 COMPLEX 21 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04062">
        <property type="entry name" value="P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016315">
        <property type="entry name" value="ARP2/3_P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69060">
        <property type="entry name" value="Arp2/3 complex 21 kDa subunit ARPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED24568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="188" mass="21307" checksum="655B81E0204D4268" modified="2009-03-03" version="1">MPAYHSIFLDEADLPLIGNFPLLPLRTRTRGPAYVLPALPPSESDLDIDPNSESYDCIDEILSLFRANVLFRNFEIKGPADRMLIYGILFLSECLGKVKANMTARDAEKALINVALEQFAIPGDVSFPLNQAFERPRDRQDAEQLRQYLSQVRQELAIRLLSRLYPGGEGPSKFWLSFAKRKFMGKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8LX57</accession>
    <name>B8LX57_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_061950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340094.1">
        <property type="nucleotide sequence ID" value="XM_002340053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LX57"/>
    <dbReference type="STRING" id="441959.B8LX57"/>
    <dbReference type="GeneID" id="8105627"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_061950"/>
    <dbReference type="eggNOG" id="ENOG502SII6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025005_3_1_1"/>
    <dbReference type="InParanoid" id="B8LX57"/>
    <dbReference type="OMA" id="HITCLID"/>
    <dbReference type="OrthoDB" id="4226944at2759"/>
    <dbReference type="PhylomeDB" id="B8LX57"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED22707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="522" mass="60427" checksum="5CA6CB8BEF4ABF7E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXK8</accession>
    <name>B8LXK8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61</fullName>
            <ecNumber evidence="1">2.1.1.220</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">tRNA(m1A58)-methyltransferase subunit TRM61</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_078640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.220" evidence="1"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341896.1">
        <property type="nucleotide sequence ID" value="XM_002341855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXK8"/>
    <dbReference type="STRING" id="441959.B8LXK8"/>
    <dbReference type="GeneID" id="8101158"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_078640"/>
    <dbReference type="eggNOG" id="ENOG502RYTV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029873_0_0_1"/>
    <dbReference type="InParanoid" id="B8LXK8"/>
    <dbReference type="OMA" id="FYVGHVE"/>
    <dbReference type="OrthoDB" id="5585464at2759"/>
    <dbReference type="PhylomeDB" id="B8LXK8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF1">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="287"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED24509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="359" mass="40172" checksum="16B5A5FF67656F28" modified="2009-03-03" version="1">MQYFVREKRKEHRLSLPTLEEYVVYTPRLVTPIYGADASLIVSLLDIHAVPPAAANKDRLEILEAGTGHGSLTLHLARAIQAANTNPPPIPQKSQVRILEERPIRPFEEGGEQQHSKEEITDAQDDVAVQKDWDEWRSQRSAVIHTVDVSPKFSRHAEQIVRGFRRGIYAGNVDFHVGAVEDWIKDQLQRRSSPAGLFKRDNATQPFLSYAILDMPAAHKRIPHVAPALRRDGLLVVFMPSITQIGECVQLIRKEKLPFVMEKVVELGTGISGGRLWDVRMAVKKSRADPSSWTKEGRDGTEAPQTGTEETDSAEPSNTSGEDSTQDNVLVCRPKVGSKIVGGGFVGIWRRIEDRRDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8LYZ2</accession>
    <name>B8LYZ2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_069210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340887.1">
        <property type="nucleotide sequence ID" value="XM_002340846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LYZ2"/>
    <dbReference type="STRING" id="441959.B8LYZ2"/>
    <dbReference type="GeneID" id="8107346"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_069210"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_3_1"/>
    <dbReference type="InParanoid" id="B8LYZ2"/>
    <dbReference type="OMA" id="FGKQSWT"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="PhylomeDB" id="B8LYZ2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF152">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED23500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="348" mass="38796" checksum="A5307CB762B090EB" modified="2009-03-03" version="1">MESTTAKGTIIVTGANGGLGSAITKEIVSKPEFSAYYGLYLVRDAAYAPALDSVLATSSKHPHEALSIDLTDLDSVRKAAEAINLRVSEGKIPQIRALVLNAGFQDFGKQTWTKDGFDTTFSVNYLGHWLLTLLLLKSIDRDAGRIVIVGSQAHDPNDKRNDSSKAFIDDKYNPMIRDKDNFEAIAKGKWSSAIEDTTWRSGFRRYGAAKLCLTMMMHELQHRMNTDPQLKSVCILGVDPGAMSTGLQRHASWFIRVLLFQIVLPLTLLLMSKPPLRPTQKSASHILQAAFDSNEVLGQYPKDLYFNGDEPLETSEESRDAQKRELVWKESVRYTQLKEGETVLAAWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZN7</accession>
    <name>B8LZN7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_097090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479423.1">
        <property type="nucleotide sequence ID" value="XM_002479378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZN7"/>
    <dbReference type="GeneID" id="8109490"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_097090"/>
    <dbReference type="eggNOG" id="ENOG502SQFY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_912697_0_0_1"/>
    <dbReference type="InParanoid" id="B8LZN7"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="PhylomeDB" id="B8LZN7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF8">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED22460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="305" mass="33125" checksum="FE2F37D6145DD186" modified="2009-03-03" version="1">MSSSERFIVDDVPLGGDLGLDSNNSLLDFEESLNASLLPYADYMVFSDAADQLVPPITSGYPGTDSLQPALSGNGLTTDLGSIVIANNMLNELESGTVDSLDALIPSYHESKDPGTEAKEGSVNPSHLMPLLESGGAILNDPYNCKGTTYLADPYKNALSFSQVTLMSVCIHNAHFLGVTIQAFFGDDYLTLCSPFYRPVSASDDPTALLASVSRPSTSRFLQPTLSQVLFPHHPIFDLIPIPAFRERAIMLAATSPSLLNPLELKQDIINGCFICWGTKYSPNHSCKGHTYRAYARIIWFLVHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZS3</accession>
    <name>B8LZS3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Norsolorinic acid reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_080880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477818.1">
        <property type="nucleotide sequence ID" value="XM_002477773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZS3"/>
    <dbReference type="STRING" id="441959.B8LZS3"/>
    <dbReference type="GeneID" id="8101393"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_080880"/>
    <dbReference type="HOGENOM" id="CLU_1428872_0_0_1"/>
    <dbReference type="InParanoid" id="B8LZS3"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="PhylomeDB" id="B8LZS3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="98"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED20855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="190" mass="21331" checksum="D28872844C470D60" modified="2009-03-03" version="1">MATVAPVADYASNVWMHACKAKGTQYLNRMQKQGAIAVTGAFRTVATAVAEAEAGIQPFHNYWKQKQKWKYGDQQAENVNQKSNCFKLKQLPSDLLSMQHAEHNVERDILPMYNDEGMAFMPYGVLGSGYFRTSAQRAAEKQDPETKREGRNIAFIDKPRKAIMADTLEDIAKARDTNLTSIALAWARSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8LZW4</accession>
    <name>B8LZW4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSTA_081290</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + H(+) = an aldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:11628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="EC" id="4.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477859.1">
        <property type="nucleotide sequence ID" value="XM_002477814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LZW4"/>
    <dbReference type="STRING" id="441959.B8LZW4"/>
    <dbReference type="GeneID" id="8101434"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_081290"/>
    <dbReference type="eggNOG" id="KOG1184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_0_2_1"/>
    <dbReference type="InParanoid" id="B8LZW4"/>
    <dbReference type="OMA" id="LGDPQWK"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="PhylomeDB" id="B8LZW4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF11">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="15">
        <location>
            <begin position="4"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="13">
        <location>
            <begin position="198"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="14">
        <location>
            <begin position="376"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EED20896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="549" mass="60682" checksum="A3F25FDCFDA51C76" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8M031</accession>
    <name>B8M031_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_081960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477926.1">
        <property type="nucleotide sequence ID" value="XM_002477881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M031"/>
    <dbReference type="STRING" id="441959.B8M031"/>
    <dbReference type="GeneID" id="8104834"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_081960"/>
    <dbReference type="eggNOG" id="ENOG502SVBM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051551_0_0_1"/>
    <dbReference type="InParanoid" id="B8M031"/>
    <dbReference type="OMA" id="MFQNIAC"/>
    <dbReference type="OrthoDB" id="4526357at2759"/>
    <dbReference type="PhylomeDB" id="B8M031"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="259" mass="27805" checksum="D2AABA99A42A7FE6" modified="2009-03-03" version="1">MRAKLKPTFWSQDCHLSRKSVILCHYDLPGVQPLTRLNAPGNTMARKGPGTDGPLQTALLESMSAAITRASEGQKIFSPIAAFLDKHHSQTTSLAPHLLRALTALSDDLASVAQQHFNAYISSISMISILPALSPSPSSSPILNPLPPSSPPSRPPSGLNQSTYATITQYAPVKSTPTTHSKSLVKKPMPLVKQPLPDNRLFVRLPADHAARKIEAYAIYSSLRSQLNSNSAVLKEVQATKTGFTLCPSSPEALLALEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0B9</accession>
    <name>B8M0B9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_084470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED21216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="441959.B8M0B9"/>
    <dbReference type="GeneID" id="8102729"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_084470"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OMA" id="SHQEIND"/>
    <dbReference type="OrthoDB" id="4369251at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009970">
        <property type="entry name" value="HC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF65">
        <property type="entry name" value="PAXILLIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07382">
        <property type="entry name" value="HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="559"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="924"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="949" mass="107792" checksum="669809EFD017E207" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0U1</accession>
    <name>B8M0U1_TALSN</name>
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        <recommendedName>
            <fullName evidence="12">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_087070</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
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        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
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    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H4 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EED21474.1"/>
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        <property type="nucleotide sequence ID" value="XM_002478392.1"/>
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    </dbReference>
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    <dbReference type="GeneID" id="8110113"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_087070"/>
    <dbReference type="eggNOG" id="KOG3467">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:protein heterodimerization activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of chromatin"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone H4"/>
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        <property type="entry name" value="Histone, subunit A"/>
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        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
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        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
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        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="14">
        <location>
            <begin position="28"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED21474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="103" mass="11370" checksum="9392CDB8AE0C52E2" modified="2009-03-03" version="1">MTGRGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISAMIYEETRGVLKTFLEGVIRDAVTYTEHAKRKTVTSLDVVYALKRQGRTLYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1Z2</accession>
    <name>B8M1Z2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_086010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478333.1">
        <property type="nucleotide sequence ID" value="XM_002478288.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M1Z2"/>
    <dbReference type="GeneID" id="8104566"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_086010"/>
    <dbReference type="eggNOG" id="KOG4245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_254182_0_0_1"/>
    <dbReference type="InParanoid" id="B8M1Z2"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="PhylomeDB" id="B8M1Z2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053230">
        <property type="entry name" value="Trans_reg_galc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="616"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="720"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="778"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="728"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="742"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED21370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1403" mass="157372" checksum="90824AF857D3B65F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8M264</accession>
    <name>B8M264_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Coatomer subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_087640</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the COPE family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478491.1">
        <property type="nucleotide sequence ID" value="XM_002478446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M264"/>
    <dbReference type="FunCoup" id="B8M264">
        <property type="interactions" value="216"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M264"/>
    <dbReference type="GeneID" id="8100893"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_087640"/>
    <dbReference type="eggNOG" id="KOG3081">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049363_1_0_1"/>
    <dbReference type="InParanoid" id="B8M264"/>
    <dbReference type="OMA" id="MIVLSQH"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="PhylomeDB" id="B8M264"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006822">
        <property type="entry name" value="Coatomer_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805:SF0">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04733">
        <property type="entry name" value="Coatomer_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016478">
        <property type="entry name" value="Coatomer_esu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED21528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="299" mass="32257" checksum="B31FEC4CD86DC36E" modified="2009-03-03" version="1">MDPFSAEGELVNIHNAFHQGQYQTVIDFDTTSFSSENALPSRILQLRAKIALKQTKDVLSEIEAETNNDDDVPDLAAVKALALQVAGNTEEALALAQKLAETKSENATVQVLVGTVLQAQGLTEEALALLGRHQGNLEAVALTVQIYLQTNRVDLAVKEVSAAKRWAQDSLLVNIAESWVGLRVGGEKYQSAFYVYEELASNPNTTAPLSIVGQAIAELHLGRLPEAEAALTSALEKYSEDVELIANTIVLNVLTGKDTAELKSRLESLQPSHVLITDLAEKSSFFDTAAAKYVPKVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8M276</accession>
    <name>B8M276_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Saccharopine dehydrogenase NADP binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_087760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478503.1">
        <property type="nucleotide sequence ID" value="XM_002478458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M276"/>
    <dbReference type="GeneID" id="8100905"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_087760"/>
    <dbReference type="eggNOG" id="KOG2733">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031002_0_1_1"/>
    <dbReference type="InParanoid" id="B8M276"/>
    <dbReference type="OMA" id="GPYQLYG"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="PhylomeDB" id="B8M276"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="12"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED21540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="421" mass="46630" checksum="FCEB26A11D7FA998" modified="2009-03-03" version="1">MSFKKHDRQYDIVVLGATGYSGLLTAEHIAVNLPSSLKWAVAGRSSDKLQKVVSRCKELNSHRIQPAIETYHLNHEEVAQLAKRAFCLITTVGPYALHGEYAFKACAEAGTHYIDCTPEVPWTLEMIKKYEATAKESGACMIPQCAMESAPSDILTWVVAEEIRSKFSSQVGDVVMDLYRLTSIPSGGTLATILNLFGHYPLKALRQSIEPYALSPVPNSNARPKRSRLSSLTGVYKIPGLGLLSTSISGKANEAIVFRTWGLFKQEPGLQKEFYGPKFTYREFMYAPGFVRGMLTHYFIVMGGYLLLLAPIRSLIRQFVFKPGDGPDIQKAKEEVIELRAVSKPDSEAEKDEQVMGKLLYKGSMYYLTATFLAEAAATVLEEDDSSRLTGGIYTPACLGQRYVNRLKAVGVQISTEVQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2L4</accession>
    <name>B8M2L4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Terminal deoxynucleotidyl transferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_091660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-X family.</text>
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        <property type="protein sequence ID" value="EED21925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002478843.1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_091660"/>
    <dbReference type="eggNOG" id="KOG2534">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008698_4_1_1"/>
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    <dbReference type="OMA" id="QEGWITH"/>
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    <dbReference type="Proteomes" id="UP000001745">
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018944">
        <property type="entry name" value="DNA_pol_lambd_fingers_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF29">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY PROTEIN POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA_pol_lambd_f"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="167"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="94"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED21925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="707" mass="78604" checksum="00A04E0F9927154B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2S2</accession>
    <name>B8M2S2_TALSN</name>
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            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">TSTA_094230</name>
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    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002479095.1"/>
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    <dbReference type="GeneID" id="8103751"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_094230"/>
    <dbReference type="eggNOG" id="ENOG502SM98">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013296_0_0_1"/>
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    <dbReference type="OMA" id="CHEVDTL"/>
    <dbReference type="OrthoDB" id="4898680at2759"/>
    <dbReference type="PhylomeDB" id="B8M2S2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec_Metabolite_Reg"/>
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    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
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    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="21"/>
            <end position="53"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED22177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="683" mass="77047" checksum="6FD356607425282B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2Z8</accession>
    <name>B8M2Z8_TALSN</name>
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        <recommendedName>
            <fullName evidence="9">NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_092160</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the complex I NDUFS4 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478937.1">
        <property type="nucleotide sequence ID" value="XM_002478892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2Z8"/>
    <dbReference type="STRING" id="441959.B8M2Z8"/>
    <dbReference type="GeneID" id="8099398"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_092160"/>
    <dbReference type="eggNOG" id="KOG3389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077196_0_0_1"/>
    <dbReference type="InParanoid" id="B8M2Z8"/>
    <dbReference type="OMA" id="YDATIDH"/>
    <dbReference type="OrthoDB" id="3089at2759"/>
    <dbReference type="PhylomeDB" id="B8M2Z8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.190:FF:000001">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 21 kDa subunit mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.190">
        <property type="entry name" value="atu1810 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006885">
        <property type="entry name" value="NADH_UbQ_FeS_4_mit-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038532">
        <property type="entry name" value="NDUFS4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219:SF8">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04800">
        <property type="entry name" value="NDUS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0830">Ubiquinone</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="25"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED21974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="216" mass="24195" checksum="41B0CCC1ACE2E01D" modified="2009-03-03" version="1">MSFIRARSVAQLRAVRIAQPVNARFFSSPTDGSVKTSPADAPTTPPKDSSLIRKEGPGEAMAHHQPDYDATIDHATSTFSPVPRRVMDGSEPGDAVAAAVLSGAPTDLQARTVRIYKPSKPATQSGTWHSHHWRMDWDVLGKGHRWENPLMGWQSSGDFMQGTHINFKSKEDAILFAQKQGYEYFVQEPNERKFVPKAYANNFMHEPKKLKHIRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3V6</accession>
    <name>B8M3V6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="5">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_039030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = (6R)-5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="5"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481133.1">
        <property type="nucleotide sequence ID" value="XM_002481088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3V6"/>
    <dbReference type="FunCoup" id="B8M3V6">
        <property type="interactions" value="207"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M3V6"/>
    <dbReference type="GeneID" id="8107945"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_039030"/>
    <dbReference type="eggNOG" id="KOG3093">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066245_2_1_1"/>
    <dbReference type="InParanoid" id="B8M3V6"/>
    <dbReference type="OMA" id="DKWGIPT"/>
    <dbReference type="OrthoDB" id="2015992at2759"/>
    <dbReference type="PhylomeDB" id="B8M3V6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10420:FF:000007">
        <property type="entry name" value="5-formyltetrahydrofolate cyclo-ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407">
        <property type="entry name" value="ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="8"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="169"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED20699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="245" mass="27362" checksum="489E5EA83DAE4CB5" modified="2009-03-03" version="1">MAAVQVAKKDLRRKIQNLLKEVPRESVNAQSTVVTNKLFTLPEYRNARRVSIFLSMPSGEISTAGIVRDALDRGKEVFVPYTHRLETGDINLPKVSVMDMLRLESMEEFESLQPDKWGIPSLDKDSVPRRQNCLGGTGVLAERSRGVSDDIGLDLIVMPGMAFDTDLRRLGHGKGYYDYFLNNYNREIAGSPRASQRPFLVAVALKEQIVIPPDEIPVANHDQPVDAIIVGDGRLIFANGRLMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3W3</accession>
    <name>B8M3W3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS sugar transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_039100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481140.1">
        <property type="nucleotide sequence ID" value="XM_002481095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3W3"/>
    <dbReference type="GeneID" id="8109248"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_039100"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="InParanoid" id="B8M3W3"/>
    <dbReference type="OMA" id="WCIFFIP"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="PhylomeDB" id="B8M3W3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF38">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="16"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED20706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="528" mass="57773" checksum="92F8CF180035123F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8M411</accession>
    <name>B8M411_TALSN</name>
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        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">TSTA_039520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481188.1">
        <property type="nucleotide sequence ID" value="XM_002481143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M411"/>
    <dbReference type="STRING" id="441959.B8M411"/>
    <dbReference type="GeneID" id="8109290"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_039520"/>
    <dbReference type="eggNOG" id="ENOG502RXPC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041178_0_0_1"/>
    <dbReference type="InParanoid" id="B8M411"/>
    <dbReference type="OMA" id="DTEQEFF"/>
    <dbReference type="OrthoDB" id="6354873at2759"/>
    <dbReference type="PhylomeDB" id="B8M411"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="196"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED20754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="365" mass="42722" checksum="D3D4095A5B416AB7" modified="2009-03-03" version="1">MGSFGDSRTGEPVDKMSSPNPKDSMKSTWRHSSKDEWTIWHWFYEVLGIHPTVLDRDVPIHSKEEPVPHLPEWKEHRWVLLHAVVPLILHETYVLYTGRNLGPVAAFFLYATAFKVIAINQLHMLRGLGHKYGFFDGDKHARDGVPDVGVAKVVHSLMSTSTFRPMMTVYLAYKTSATPAAELRANWAWLIMEVSLYGIILDFWFYWYHRLMHDVDVLWKYHRTHHLTKHPNPLLTLYADTEQEFWDIAGIPLLTYGTMKLMGMPMGFYEWWLCHQYIVFTELAGHSGLRIHATPPSPLSWLLKWFDAELVIEDHDLHHRTGWKKSHNYGKQTRLWDKIFGTCRERIESGKGMVDYNSTVDMPWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8M4Z3</accession>
    <name>B8M4Z3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL49</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_027250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL49 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479862.1">
        <property type="nucleotide sequence ID" value="XM_002479817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M4Z3"/>
    <dbReference type="STRING" id="441959.B8M4Z3"/>
    <dbReference type="GeneID" id="8109644"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_027250"/>
    <dbReference type="eggNOG" id="KOG4034">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085757_0_1_1"/>
    <dbReference type="InParanoid" id="B8M4Z3"/>
    <dbReference type="OMA" id="HIVVKGW"/>
    <dbReference type="OrthoDB" id="19439at2759"/>
    <dbReference type="PhylomeDB" id="B8M4Z3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000030">
        <property type="entry name" value="Mitochondrial large ribosomal subunit L49, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007740">
        <property type="entry name" value="Ribosomal_mL49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05046">
        <property type="entry name" value="Img2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED19428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="194" mass="21794" checksum="219ADA11B8C847BE" modified="2009-03-03" version="1">MASITRSLTTMSTVRHQLSTVNSTRQFSILHNHTQRLLSRNGIANQLSHNPTSSRSLLPVQQYRTFLAKLARRFPASTQFTRPPISPVETEAPSSTQAQTAPLQLTNLPYFVRRTPSNKLPVYLETKAGGTKRLTKIQKTEGDLEALKSDLAKALNLETGSKKPEITINSTTGHIIVKGWRKDEIQKFLIERNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6A3</accession>
    <name>B8M6A3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mso1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_025930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479712.1">
        <property type="nucleotide sequence ID" value="XM_002479667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6A3"/>
    <dbReference type="GeneID" id="8108005"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_025930"/>
    <dbReference type="eggNOG" id="ENOG502S4EA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061436_0_1_1"/>
    <dbReference type="InParanoid" id="B8M6A3"/>
    <dbReference type="OMA" id="GRPFPSW"/>
    <dbReference type="OrthoDB" id="2683368at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028095">
        <property type="entry name" value="Mso1_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14475">
        <property type="entry name" value="Mso1_Sec1_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mso1 N-terminal" evidence="2">
        <location>
            <begin position="23"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="221" mass="23082" checksum="E4CF0DB0F993F7DA" modified="2009-03-03" version="1">MSSYFASLASSTTISNLGTRLNSLRRAITSGDEKDDPDNEDCSHISNVLRAYYTEKGRPFPEWLPPDPKAPAAQPRLVATQASLQQGSTSPYGQPQATYTGRGGGLGDLWGESGPAEPPQTQTSSLRSRVSRRPLPSQRGDTYPSHSSSGGASGGGSASERLRARLQGGGSSQSPPPSRPQQQYQAYSWDGGQGQGGYGASGGSGGYKRPGGLPSGPKPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6Z6</accession>
    <name>B8M6Z6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_034540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480650.1">
        <property type="nucleotide sequence ID" value="XM_002480605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6Z6"/>
    <dbReference type="GeneID" id="8104296"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_034540"/>
    <dbReference type="HOGENOM" id="CLU_957053_0_0_1"/>
    <dbReference type="InParanoid" id="B8M6Z6"/>
    <dbReference type="OrthoDB" id="4324149at2759"/>
    <dbReference type="PhylomeDB" id="B8M6Z6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="4">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="115"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED20216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="33379" checksum="A442B696815C9022" modified="2009-03-03" version="1">MTRSLKQLGRYSKVEICPPETLADLAYSIHVLVHQIEGSQSYIFQRPKHHQMTAEEYKKKEIIAKAVNAYKRGKIKNILRLAREFGVSRSKLYRRVSGTPSCSTRPPTNRLLSLDQEKALTSWVQYLDNMGAAPTALQIEENANCLLLKDFTGPGTPRRAAKIGYTNISNVYQKNINESSKNLKELNVRLPGIMVRLNGGLLISNWLWMTSKLPPRIFTTLTRLHLLLERGKRRQWLQHTQKHQKGFLACLLESLTVVECINAEGKVIPPLIIPKGEKHMEEWYKHIKDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7E9</accession>
    <name>B8M7E9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_035950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480803.1">
        <property type="nucleotide sequence ID" value="XM_002480758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7E9"/>
    <dbReference type="STRING" id="441959.B8M7E9"/>
    <dbReference type="GeneID" id="8101866"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_035950"/>
    <dbReference type="eggNOG" id="ENOG502SWU4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_522849_0_0_1"/>
    <dbReference type="InParanoid" id="B8M7E9"/>
    <dbReference type="OrthoDB" id="5341904at2759"/>
    <dbReference type="PhylomeDB" id="B8M7E9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED20369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="589" mass="65323" checksum="25B28CAF457950B9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8M977</accession>
    <name>B8M977_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">D-serine dehydratase</fullName>
            <ecNumber evidence="11">4.3.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">D-serine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_112080</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the conversion of D-serine to pyruvate and ammonia. May play a role in D-serine detoxification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13977"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="EC" id="4.3.1.18"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:13978"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DSD1 family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.18" evidence="11"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481364.1">
        <property type="nucleotide sequence ID" value="XM_002481319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M977"/>
    <dbReference type="FunCoup" id="B8M977">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M977"/>
    <dbReference type="GeneID" id="8098863"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_112080"/>
    <dbReference type="eggNOG" id="ENOG502QRZ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031639_0_0_1"/>
    <dbReference type="InParanoid" id="B8M977"/>
    <dbReference type="OMA" id="WPRFYGW"/>
    <dbReference type="OrthoDB" id="20198at2759"/>
    <dbReference type="PhylomeDB" id="B8M977"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036088">
        <property type="term" value="P:D-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000016">
        <property type="entry name" value="D-serine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.20">
        <property type="entry name" value="D-serine dehydratase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051466">
        <property type="entry name" value="D-amino_acid_metab_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026956">
        <property type="entry name" value="D-ser_dehydrat-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042208">
        <property type="entry name" value="D-ser_dehydrat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004:SF2">
        <property type="entry name" value="D-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004">
        <property type="entry name" value="ZGC:162816-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14031">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01119">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0216">Detoxification</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="D-serine dehydratase-like" evidence="14">
        <location>
            <begin position="281"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED17372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="396" mass="43634" checksum="EE80FD3973B8159C" modified="2009-03-03" version="1">MDVSLETHQSYIGQPASALPTPALVISKPVLESNVKKLHEDIDTLGIGFRPHVKTLKSIETTRIMLANGRYKKIVASTLCEIRGCLPLVKEGILDECLYGLPIRPSVLADLDKFTSQYGLKIVLMVDHSDHIRILEEFNTRTGRTTPWPVFIKVDVGTKRAGIQNSSSRLDEVIQSANESEGVSIHGFYCHAGHSYASKSTEDAVKVLNDEINGVLIAAKKLIDPKTELVLSIGATPTAHVVSNLKASLPKNTQLELHAGNFPANDLQQVATGLVSLSDQAVRVVAEVCSVYPERNEALINAGVLALTKETSSFAGLARWTDGIDWSIVRVSQEHGIFGWVGDDAKREKVEEKFKIGQKVLLYTQHACITSAMFHAFYVVDKQDIVRETWVPWKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9G1</accession>
    <name>B8M9G1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS monosaccharide transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_115200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481713.1">
        <property type="nucleotide sequence ID" value="XM_002481668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9G1"/>
    <dbReference type="GeneID" id="8101330"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_115200"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="InParanoid" id="B8M9G1"/>
    <dbReference type="OMA" id="VAFANIQ"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="PhylomeDB" id="B8M9G1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="25"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED17721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="552" mass="61368" checksum="26B14015F365FA3D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9Y3</accession>
    <name>B8M9Y3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LaeA-like methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_118990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482127.1">
        <property type="nucleotide sequence ID" value="XM_002482082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M9Y3"/>
    <dbReference type="STRING" id="441959.B8M9Y3"/>
    <dbReference type="GeneID" id="8108573"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_118990"/>
    <dbReference type="eggNOG" id="ENOG502SNAB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_9_1_1"/>
    <dbReference type="InParanoid" id="B8M9Y3"/>
    <dbReference type="OMA" id="DCDTTAF"/>
    <dbReference type="OrthoDB" id="4222303at2759"/>
    <dbReference type="PhylomeDB" id="B8M9Y3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="1">
        <location>
            <begin position="51"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="290" mass="32297" checksum="7A396D064FB66850" modified="2009-03-03" version="1">MPAITDEIYILSRDQTESARLEEQHAFFVEVTGGKPIHPSIEQGNLFAVADIATGTGAWLRDVSQLLSTIPDDPQRYYHGFDISSAQFPSTPFQSNMEFSVHDILQPFPQEHMGRYDLVNVRFLLGAIKEADYFTAINNAATLLKPNGYLQWAELDTDLFSQNKPREFPRFSEIIRLVFALNQNGMCSHASDAVYYAALFSSCLTCVTKHVYSSLDNAKLNEKARAWCLNGFSALLPGGLVRSKTLAATSSPEEVQDLTKRLLQEVKELFGRGVVPDGRFGVVVAQKRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAE2</accession>
    <name>B8MAE2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase, zinc-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_123730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482636.1">
        <property type="nucleotide sequence ID" value="XM_002482591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAE2"/>
    <dbReference type="FunCoup" id="B8MAE2">
        <property type="interactions" value="417"/>
    </dbReference>
    <dbReference type="GeneID" id="8108284"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_123730"/>
    <dbReference type="eggNOG" id="KOG1196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_29_2_1"/>
    <dbReference type="InParanoid" id="B8MAE2"/>
    <dbReference type="OMA" id="EEKCRYA"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="PhylomeDB" id="B8MAE2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF42">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, ZINC-CONTAINING (AFU_ORTHOLOGUE AFUA_7G04530)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="24"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED18644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="361" mass="39212" checksum="E4E6A6CB4D4AC7E7" modified="2009-03-03" version="1">MAIANKQIIYTHPPSPAINPDLSSNNGTFSLRQSSISLPIPTDKLLVRNHYLSLDPAMRQWLTAKRSYIAPVELGDVMRSLAIAQIVDVGESLTSQFKKGEWLIAVTGWQEYALLGAKEAAKQRAVVPPGCSPMDAMAVLGTTGLTAYFGLLEVGQMRAGDTVVVSGAAGATGMIVGQIARIKGAKRVVGIAGSPDKCRFLTEELGFDVAINYKDKDWKKQLRAACPEYIDVYFDNVGGEILDVCLGLAAKDARFPISGHISQYSAAKPEGPRNIMMLIGQRVMMKGFIYLDYHKKFPSAIADLQKWLIEGKIKRKEYIIKGGLEACPQGLVDMYAGANTGKTMVEVVPFSKAIQETPAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAM6</accession>
    <name>B8MAM6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">50S ribosomal protein Mrp49</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_112820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481442.1">
        <property type="nucleotide sequence ID" value="XM_002481397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAM6"/>
    <dbReference type="STRING" id="441959.B8MAM6"/>
    <dbReference type="GeneID" id="8105747"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_112820"/>
    <dbReference type="eggNOG" id="ENOG502SDFJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094283_0_0_1"/>
    <dbReference type="InParanoid" id="B8MAM6"/>
    <dbReference type="OMA" id="FWREMLP"/>
    <dbReference type="OrthoDB" id="1696305at2759"/>
    <dbReference type="PhylomeDB" id="B8MAM6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040049">
        <property type="entry name" value="Ribosomal_mS25/mL61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED17450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="206" mass="23637" checksum="079C79272924EB82" modified="2009-03-03" version="1">MVNLFKRMRKLNHRLINVRVGTGAATLPSISSPLNNLPAVTRMHLTYGKSVGRGHIGAQKFWRKCLLRLKYYNPAIQMTVKPYDGEERHAALTIFFSGVQPQKAQAYHDASIKDEFAPSPTESEKAVVLNLKDYNFEEIWQQVKELTGAVEVEPTAEDKEQLEKFRQMDIKSEADRIRVAGIRQAKKDQERMLQEARGEVEKLREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAQ8</accession>
    <name>B8MAQ8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_115460</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481740.1">
        <property type="nucleotide sequence ID" value="XM_002481695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAQ8"/>
    <dbReference type="FunCoup" id="B8MAQ8">
        <property type="interactions" value="746"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MAQ8"/>
    <dbReference type="GeneID" id="8101356"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_115460"/>
    <dbReference type="eggNOG" id="KOG3071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048483_6_1_1"/>
    <dbReference type="InParanoid" id="B8MAQ8"/>
    <dbReference type="OMA" id="WTYFTST"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="PhylomeDB" id="B8MAQ8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF134">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="302"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED17748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="342" mass="39030" checksum="7699293D5F66CC6A" modified="2009-03-03" version="1">MSFDLKHIPLPTIDRPFGIELWPIFNKAFEAVRGYPAEDFRFVNGETPMSTFSETAIALVTYYVVIFGGREVMKKLPAFKLNFLFMVHNFILTAVSGILLVLFLEQLIPTLYHHGVFYAICDHNGGWTQPLVVLYYLNYLNKYLEFIDTVFLVLKKKPLTFLHTYHHGATALLCWTQLIGLTSVSWVPITLNLAVHVVMYWYYFQSARGIRIWWKKYITIFQIIQFVIDLFFIYFASYTYFSSTYFPWAPNMGTCAGEEFAAFAGMGILTSYLVLFISFYLVTYKKAAKTGRPRSNTGRQALIDMKDAEVPSPIAAGRKAQASSNGATTTGRQGPVTRSRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAV7</accession>
    <name>B8MAV7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_115890</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481789.1">
        <property type="nucleotide sequence ID" value="XM_002481744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAV7"/>
    <dbReference type="FunCoup" id="B8MAV7">
        <property type="interactions" value="126"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MAV7"/>
    <dbReference type="GeneID" id="8099616"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_115890"/>
    <dbReference type="eggNOG" id="KOG3140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041954_0_0_1"/>
    <dbReference type="InParanoid" id="B8MAV7"/>
    <dbReference type="OMA" id="YHDEFTD"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="PhylomeDB" id="B8MAV7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="148"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="374"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="383"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED17797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="409" mass="45518" checksum="27DA97FE666080C7" modified="2009-03-03" version="1">MPADYTSTARALSLPVSEPEDQQSPLFSPLRPPWSHSPVLSRRGSRPLSMGEAVSFRDRIINQAEFFYRTIKDRWEKLTLVQKIIYFTGSLLVGALGVASLILAGKIFIWLGPVAEKWEHSPLAYVVVWFLIILVSFPPLVGWSTLGTISGFLFGFWKGWIIYATATIVGSTLSFIVSRTVLTGFVKGMMENNKRFAALALTLKYDGLKLLCMIRLCPLPYSFCNGAVSTFHTVKPLSYGLATAIISPKLMVPAFIGSRIRILSENNEKMSAGSKAINVISIIISVSIGVATGFYIYRRTLARAKELEAEERAGIRRSIQEDHAAGRHHHEFSDDPDVNAAAKTLARDEEAQLGLYDEDNIDIDVGDELAEARRNRSYRDEFTDNDSDVFDDGDGDESDTYGLHTHVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8MB27</accession>
    <name>B8MB27_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular SCP domain protein Pry1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_124510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482720.1">
        <property type="nucleotide sequence ID" value="XM_002482675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MB27"/>
    <dbReference type="STRING" id="441959.B8MB27"/>
    <dbReference type="GeneID" id="8098402"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_124510"/>
    <dbReference type="eggNOG" id="KOG3017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035730_6_2_1"/>
    <dbReference type="InParanoid" id="B8MB27"/>
    <dbReference type="OMA" id="KPRFTHE"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="PhylomeDB" id="B8MB27"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000031">
        <property type="entry name" value="Extracellular SCP domain-containing protein Pry1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877651" evidence="1">
        <location>
            <begin position="17"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="64"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED18728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="242" mass="27015" checksum="E51CB65311147E28" modified="2009-03-03" version="1">MRYLSFYFLSFHTVLASNYSLPQTLTRAPPTPTLEQRAGTIIVVTVTVTPSAAPVSPSYTNPELFEYDILNQTNYYRRQHNATGVIWNDTLATYAKQWAKPCNWKHSGGPYGENLAEGYSNVTAAVDAWAIESKKYDYNRPTGFSEKTGHFTQLVWKATTDVGCGLADCSANLNGDNGGKTGKAVGWFLVCEYWPPGNVVGDHDKYFEENVEPLVSLGTWLKVNVFDVWLMIVFAVLILTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBH8</accession>
    <name>B8MBH8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_116320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481834.1">
        <property type="nucleotide sequence ID" value="XM_002481789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBH8"/>
    <dbReference type="STRING" id="441959.B8MBH8"/>
    <dbReference type="GeneID" id="8102024"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_116320"/>
    <dbReference type="eggNOG" id="ENOG502SI3F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014331_1_0_1"/>
    <dbReference type="InParanoid" id="B8MBH8"/>
    <dbReference type="OMA" id="IGWAFNC"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="PhylomeDB" id="B8MBH8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="555" mass="63447" checksum="A3C1ADD4355D02DA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBQ9</accession>
    <name>B8MBQ9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="10">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_119540</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="10"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482184.1">
        <property type="nucleotide sequence ID" value="XM_002482139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBQ9"/>
    <dbReference type="FunCoup" id="B8MBQ9">
        <property type="interactions" value="421"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MBQ9"/>
    <dbReference type="GeneID" id="8105229"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119540"/>
    <dbReference type="eggNOG" id="KOG3964">
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        <property type="reaction ID" value="UER00503"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="204"/>
        </location>
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    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED18192.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="533" mass="60054" checksum="F23A467EBA9F1675" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBU9</accession>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED18232.1"/>
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    <dbReference type="GeneID" id="8105262"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="4224510at2759"/>
    <dbReference type="PhylomeDB" id="B8MBU9"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094:SF1">
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    </dbReference>
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    </dbReference>
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            <begin position="478"/>
            <end position="572"/>
        </location>
    </feature>
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        <location>
            <begin position="205"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="639"/>
        </location>
    </feature>
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        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED18232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="639" mass="72051" checksum="7B9317F7CEB28907" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MC31</accession>
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        <submittedName>
            <fullName evidence="4">Choline oxidase (CodA), putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">TSTA_122130</name>
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    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
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        <property type="protein sequence ID" value="EED18477.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002482424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MC31"/>
    <dbReference type="STRING" id="441959.B8MC31"/>
    <dbReference type="GeneID" id="8105499"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_122130"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_7_1_1"/>
    <dbReference type="InParanoid" id="B8MC31"/>
    <dbReference type="OMA" id="NHFESCA"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="PhylomeDB" id="B8MC31"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF152">
        <property type="entry name" value="OXIDASE (CODA), PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
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    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>FAD</name>
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        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED18477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="542" mass="60094" checksum="0571F8561C6F2F3F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MCN5</accession>
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        <recommendedName>
            <fullName evidence="4">HypA-like protein</fullName>
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    </protein>
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        <name evidence="2" type="ORF">TSTA_126450</name>
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    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002482884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MCN5"/>
    <dbReference type="STRING" id="441959.B8MCN5"/>
    <dbReference type="GeneID" id="8099072"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_126450"/>
    <dbReference type="eggNOG" id="ENOG502S69W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019145_2_1_1"/>
    <dbReference type="InParanoid" id="B8MCN5"/>
    <dbReference type="OMA" id="WLKIARM"/>
    <dbReference type="OrthoDB" id="10004862at2759"/>
    <dbReference type="PhylomeDB" id="B8MCN5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF7">
        <property type="entry name" value="BAEYER-VILLIGER OXIDASE MDPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="49352" checksum="72C30ED59745C352" modified="2009-03-03" version="1">MPAVQASKVKLSPQHLGFARIDDSPAGVIETANELLQKNHDSYHMYFRDVGGHNHISHSILSVLAMGGGPEELKRAYDDGYGYQRPLPPLDPAVVQELSDPEKFRARMFNLDQYTNFLIFFEHEIEIKGWKAVVQEYCFSRTSLAETMFFQLYEGLLHPIIHLGFGVEFEQPSLIAEGLAHAASHDPGNIDTFFHRSEQLAQSGTVPSRPLIELYEEVRRNEKTRTAGRMQDGPWRLRDGPLARCMDEIVGIAAKFQISPEDLERRTAEMINCAAYSAVDFFIMHDVTCSIFLSVLVKQPWIKVEDKTRLVEWKTRLDLAWYAANGAAELRLEDISGYAPTASKGMDWRELYKAVNQVHDDGHIAKFVRALKNGQEASRPFEEGEWASLFPIKGDLWLKIAQMGYDTTKDGIDNGDKWVWGAGFDLAWMKVPNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDU2</accession>
    <name>B8MDU2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="2">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_120680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482313.1">
        <property type="nucleotide sequence ID" value="XM_002482268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MDU2"/>
    <dbReference type="FunCoup" id="B8MDU2">
        <property type="interactions" value="492"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MDU2"/>
    <dbReference type="GeneID" id="8100052"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_120680"/>
    <dbReference type="eggNOG" id="KOG3157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059988_2_0_1"/>
    <dbReference type="InParanoid" id="B8MDU2"/>
    <dbReference type="OMA" id="HIPFHLI"/>
    <dbReference type="OrthoDB" id="10264196at2759"/>
    <dbReference type="PhylomeDB" id="B8MDU2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06822">
        <property type="entry name" value="PLPDE_III_YBL036c_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00044">
        <property type="entry name" value="YggS family pyridoxal phosphate-dependent enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146:SF14">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine racemase N-terminal" evidence="4">
        <location>
            <begin position="132"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED18321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="340" mass="37174" checksum="5E9740BCF4DB7E5D" modified="2009-03-03" version="1">MPLEIPTNDPRRGKKFPSAIYTTFLLLSLLAKIEMTSTLDTVTMSTPARTATLLTNLNNVLARISAASSIFQTTSTSTTRRHRPADKPVRLVAVSKLKPASDILALYSPSSFPSDETPTATTTTPSATQQLHFGENYFQELLEKSRILPRGIRWHFIGGLQSNKCTSLARDVRGLWAVESVDTEKKAKLLDKGWGERDFTSLSTEEQQQKLRVFVQVNTSGEENKSGVEPALTPALCRYIRDNCPGLKLQGLMTIGAIARSKETTADKENEDFVTLIETREVVVRELGLTEQEADDFELSMGMSSDFEGAIALGSDQVRVGTTIFGERPVKAGANAGAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEC3</accession>
    <name>B8MEC3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_016290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483784.1">
        <property type="nucleotide sequence ID" value="XM_002483739.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MEC3"/>
    <dbReference type="GeneID" id="8106402"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_016290"/>
    <dbReference type="eggNOG" id="KOG2648">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_254057_0_0_1"/>
    <dbReference type="InParanoid" id="B8MEC3"/>
    <dbReference type="OrthoDB" id="3903581at2759"/>
    <dbReference type="PhylomeDB" id="B8MEC3"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010014">
        <property type="entry name" value="DHP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00272">
        <property type="entry name" value="DPH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00408">
        <property type="entry name" value="Diphthamide_biosynthesis_famil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="430"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="991"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1083"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1119"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1168"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="998"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1089"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1179"/>
            <end position="1189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00080784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED16550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1405" mass="156185" checksum="75FC33F56AD58A0E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEI7</accession>
    <name>B8MEI7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_016890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483848.1">
        <property type="nucleotide sequence ID" value="XM_002483803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEI7"/>
    <dbReference type="GeneID" id="8103662"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_016890"/>
    <dbReference type="eggNOG" id="ENOG502RACM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_573877_0_0_1"/>
    <dbReference type="InParanoid" id="B8MEI7"/>
    <dbReference type="OrthoDB" id="4227165at2759"/>
    <dbReference type="PhylomeDB" id="B8MEI7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="476" mass="53335" checksum="FD716D37B8BF5BFA" modified="2009-03-03" version="1">MPTHGQHKQQQPRRILEKSRTVRRRYQRSNKRFEFTASQIEQIEREEEREKKAKQLREREKRKLANKKKRAEKEAKQREERRRLGIPDPNTVKIPASQPLLVNFLGARRNSKLDEVKGQIQEEAEDFGTNLEPENSEGEELDESGDDGHGDHHISPVQEEADVLQQQQQPSKTEEAVNCVSEDFSDLETELGDDLLDDIDLEKHIASIENSQKSLNSSATTHNAIQTQVPAQSMLEAPPAVNSLSESFEDDTSLLLQTLDPTILENFENPKPTAVSHDLNKTKGLDAEPVTHPVVQSSSAPIHALPNVKTVNTQYVSHIANNLTPTKFSHASRNTTLGTSAHQPSPKVWAPNQQPVQKQQLECPNINKNVNSASIYSAPSVDAFKKSVAVASSSLQQRGHLHSLPEKCVNQDTKTLLAEKSYPQSYVDVEDEFGDLPLSTQDVRDLDMNRTIVGDIAQNGRPFPTYSDVLLEELGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEM0</accession>
    <name>B8MEM0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_019650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484137.1">
        <property type="nucleotide sequence ID" value="XM_002484092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEM0"/>
    <dbReference type="GeneID" id="8104660"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_019650"/>
    <dbReference type="eggNOG" id="ENOG502SE3P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110778_4_0_1"/>
    <dbReference type="InParanoid" id="B8MEM0"/>
    <dbReference type="OMA" id="FHFVFAY"/>
    <dbReference type="OrthoDB" id="2122304at2759"/>
    <dbReference type="PhylomeDB" id="B8MEM0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371">
        <property type="entry name" value="INNER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371:SF2">
        <property type="entry name" value="MAPEG FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED16903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="160" mass="18327" checksum="78255BE4E4EE3BE8" modified="2009-03-03" version="1">MAQVLSKMTSLITNLGLAANNYTSAFILWNWAYAYLLTSPRTLTIRAGLDHNENPRFDLAKYGERAVTEGKLTRKRLQQIQRAQSAHQNSIESFALFASTMVLMNVAKLDAETINLIGALYSIFRVSYVKAYYYIEDRHLSILRSIVWHCGNFSCFYGIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MES5</accession>
    <name>B8MES5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-oxoacyl-(Acyl-carrier-protein) reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_020170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484192.1">
        <property type="nucleotide sequence ID" value="XM_002484147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MES5"/>
    <dbReference type="STRING" id="441959.B8MES5"/>
    <dbReference type="GeneID" id="8108828"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_020170"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="InParanoid" id="B8MES5"/>
    <dbReference type="OMA" id="SIAQTCA"/>
    <dbReference type="OrthoDB" id="4131217at2759"/>
    <dbReference type="PhylomeDB" id="B8MES5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF66">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED16958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="314" mass="32997" checksum="7950DCFCC8BF7380" modified="2009-03-03" version="1">MTSSAKRRLQALSQQLVEGIPDAGTFEDIPRIRSVAGDSVGQRVKDKVVIVTGANSPIGIGRASAHQFARNGAKAVYLCDYDDTYLATHKREIESLYPGVEVQIRQFDAGDAPSVKSVVDNAIEKYGRLDIMFANAGVVGSTKLFTEIEPEEFMRTLRTNTLGVFLAAKYAAPAMQITSPSKPFPSGSIICTASVAGLRSNAGGTDYSASKAAVINVAQTTCYQLAGTGVRVNAICPGVIETGMTKIMYDAARARGTEKKIGQLNPLGRGAVADEVARVALFLGSDESSYVNGQAVTVCGGLSAGHPFVPGKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFF8</accession>
    <name>B8MFF8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF726 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_017660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483926.1">
        <property type="nucleotide sequence ID" value="XM_002483881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFF8"/>
    <dbReference type="FunCoup" id="B8MFF8">
        <property type="interactions" value="74"/>
    </dbReference>
    <dbReference type="ESTHER" id="talsn-b8mff8">
        <property type="family name" value="Duf_726"/>
    </dbReference>
    <dbReference type="GeneID" id="8109023"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_017660"/>
    <dbReference type="eggNOG" id="KOG2385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001695_1_0_1"/>
    <dbReference type="InParanoid" id="B8MFF8"/>
    <dbReference type="OMA" id="KEVGWEV"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="PhylomeDB" id="B8MFF8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035650">
        <property type="term" value="F:AP-1 adaptor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035652">
        <property type="term" value="P:clathrin-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF3">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="360"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="901"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="957"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1035"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="965"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="976"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1051"/>
            <end position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED16692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1111" mass="121430" checksum="F3944F1B41BF2BE9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFV0</accession>
    <name>B8MFV0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_009390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483051.1">
        <property type="nucleotide sequence ID" value="XM_002483006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFV0"/>
    <dbReference type="STRING" id="441959.B8MFV0"/>
    <dbReference type="GeneID" id="8100800"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_009390"/>
    <dbReference type="HOGENOM" id="CLU_2211733_0_0_1"/>
    <dbReference type="InParanoid" id="B8MFV0"/>
    <dbReference type="OMA" id="EHYANDA"/>
    <dbReference type="OrthoDB" id="4462805at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED15817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="107" mass="12935" checksum="12D63D92F91E2306" modified="2009-03-03" version="1">MSDNSKQLEVLMKIIEQSPLRFICPKCLKGFPRGDKLNEHFRDSKDEIHQGLFINNHNSRQFHEFYQQALDLEIPFQDFQRKNRAQVFELAFILEHIRKKEPNSYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8MG69</accession>
    <name>B8MG69_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyldiphosphate specific]</fullName>
            <ecNumber evidence="5">2.5.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_010530</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>n isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate</text>
            <dbReference type="Rhea" id="RHEA:53008"/>
            <dbReference type="Rhea" id="RHEA-COMP:19494"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:136960"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.87" evidence="5"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483170.1">
        <property type="nucleotide sequence ID" value="XM_002483125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MG69"/>
    <dbReference type="FunCoup" id="B8MG69">
        <property type="interactions" value="269"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MG69"/>
    <dbReference type="GeneID" id="8105692"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_010530"/>
    <dbReference type="eggNOG" id="KOG2818">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051870_1_0_1"/>
    <dbReference type="InParanoid" id="B8MG69"/>
    <dbReference type="OMA" id="AWSSCAG"/>
    <dbReference type="OrthoDB" id="19639at2759"/>
    <dbReference type="PhylomeDB" id="B8MG69"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038887">
        <property type="entry name" value="Nus1/NgBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528:SF0">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="21"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="269"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EED15936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="378" mass="42096" checksum="6C863075FE0563C8" modified="2009-03-03" version="1">MVSSKDAEIFREDARLRGKKLTPAEREKLLKPYLPEPAKEEDMNTTKQARKSKSTKSKSKSKPTPIRTFLKSQIHRLIYVLIHLCLGFYIRITQTIAAVTDRVLAVTYYHHRSPELIARDVKGLSRLPEHLSVLLKLRKREEDALQTLMDETAELAAWTTCAGIPVLSVYEKTAISDKLALYYGSPSNQPHLCICAPHHSSYAPASHIKSKGQKKPSLTVLLLSHSDGRETLVDLTKTLTEMAQSGKLSPNDISTKLIDAEISELTSCLSSSSSSSSPPSPPPASSSVPNESYSDNDTEMLPSSLFHPIKPEPDLLIIFGPIVRLEGYPPWQVRLTEIFCTGDKTSSIAGGNEEVTVEYQGFLRALWRYARASFRYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>B8MG87</accession>
    <name>B8MG87_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dynamin GTPase</fullName>
            <ecNumber evidence="2">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_010700</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="2"/>
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        <property type="protein sequence ID" value="EED15954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_002483188.1">
        <property type="nucleotide sequence ID" value="XM_002483143.1"/>
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    <dbReference type="AlphaFoldDB" id="B8MG87"/>
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        <property type="interactions" value="1360"/>
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    <dbReference type="STRING" id="441959.B8MG87"/>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_010700"/>
    <dbReference type="eggNOG" id="KOG0446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008964_5_0_1"/>
    <dbReference type="InParanoid" id="B8MG87"/>
    <dbReference type="OMA" id="KICHNCG"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="PhylomeDB" id="B8MG87"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:endocytosis"/>
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        <property type="term" value="P:establishment of mitochondrion localization, microtubule-mediated"/>
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        <property type="term" value="P:heme transport"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:intracellular distribution of mitochondria"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:macroautophagy"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:membrane bending"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:mitochondrial membrane fission"/>
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        <property type="term" value="P:mitochondrion inheritance"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:protein homooligomerization"/>
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        <property type="term" value="P:vacuole fission"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Dynamin-1-like protein isoform 1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Dynamin"/>
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        <property type="entry name" value="Dynamin_GTPase_CS"/>
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        <property type="entry name" value="Dynamin_N"/>
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        <property type="entry name" value="Dynamin_stalk"/>
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        <property type="entry name" value="G_DYNAMIN_dom"/>
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        <property type="entry name" value="GED"/>
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        <property type="entry name" value="GED_dom"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DYNAMIN-RELATED PROTEIN DNM1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Dynamin_M"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DYNAMIN"/>
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        <property type="entry name" value="DYNc"/>
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        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
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    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="14">
        <location>
            <begin position="27"/>
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    <feature type="domain" description="GED" evidence="13">
        <location>
            <begin position="701"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="549"/>
            <end position="601"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="625"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
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    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
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    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED15954.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="788" mass="87561" checksum="6EB747D96157E180" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGK9</accession>
    <name>B8MGK9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exocyst complex component Sec3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_018310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_002483994.1">
        <property type="nucleotide sequence ID" value="XM_002483949.1"/>
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    <dbReference type="STRING" id="441959.B8MGK9"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_002075_1_0_1"/>
    <dbReference type="InParanoid" id="B8MGK9"/>
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    <dbReference type="PhylomeDB" id="B8MGK9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13315">
        <property type="entry name" value="PH_Sec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.90:FF:000003">
        <property type="entry name" value="Exocyst complex component Sec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028258">
        <property type="entry name" value="Sec3-PIP2_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048628">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15277">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20654">
        <property type="entry name" value="Sec3_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01313">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 PIP2-binding N-terminal" evidence="6">
        <location>
            <begin position="90"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="538"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="580"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED16760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1443" mass="160509" checksum="C34A4FA6CE41715A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGZ1</accession>
    <name>B8MGZ1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_014640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483606.1">
        <property type="nucleotide sequence ID" value="XM_002483561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGZ1"/>
    <dbReference type="STRING" id="441959.B8MGZ1"/>
    <dbReference type="GeneID" id="8107847"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_014640"/>
    <dbReference type="eggNOG" id="ENOG502SENS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_5_5_1"/>
    <dbReference type="InParanoid" id="B8MGZ1"/>
    <dbReference type="OMA" id="HATYDRI"/>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="PhylomeDB" id="B8MGZ1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF6">
        <property type="entry name" value="ISOCHORISMATASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED16372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="180" mass="19832" checksum="6C515632423EBBFD" modified="2009-03-03" version="1">MSRTAIFAIDIQNGLANSATEIPHAPRIRQAAETILSSLRARSSGPDIFIVQHEEGPESGDLVRSTEPWELVFPPRGEEEKVVYKHTCNTLDSNPDLINQLRAQEIGTLVMFGIQSEFCVRETSLGALAAGFKVIILQGAHSTYDDSGTGKSAMQIEREVEEEVKANGGIIIPWEKWLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MH43</accession>
    <name>B8MH43_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_019200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ERGIC family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484091.1">
        <property type="nucleotide sequence ID" value="XM_002484046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MH43"/>
    <dbReference type="FunCoup" id="B8MH43">
        <property type="interactions" value="729"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MH43"/>
    <dbReference type="GeneID" id="8104615"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_019200"/>
    <dbReference type="eggNOG" id="KOG2667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034705_1_0_1"/>
    <dbReference type="InParanoid" id="B8MH43"/>
    <dbReference type="OMA" id="QRHEGCR"/>
    <dbReference type="OrthoDB" id="270930at2759"/>
    <dbReference type="PhylomeDB" id="B8MH43"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061852">
        <property type="term" value="C:retrograde transporter complex, Golgi to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="8"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
        <location>
            <begin position="153"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED16857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="440" mass="49092" checksum="B932495D14DD1A48" modified="2009-03-03" version="1">MPAKSRFTRLDAFAKTVEDARVRTTSGGIVTLVSLVVILWLVWGEWADYRRVVVLPELIVDKSRGERMEIHLNMTFPRLPCELLTLDVMDVSGEQQMGVVHGLNKVRLSPVAEGGKVIDVAKLELHAQNEVAVHLNPEYCGQCGGAPPPPNTNKPGCCNTCEEVREAYALKSWAFGKGENIEQCQREGYAEKINAQRREGCRIEGDIRVNKVIGNFHIAPGRSFSTGNMHVHDLDTYMDRELSDNEKHTMSHIIHQLRFGPQLSDELSRRWQWTDHHHTNPLDDTQQFTDEPAYNYNYYIKVVSTSYLPLGWDSSQSDQLHGDDQSTPLGLHGAVHGAAGSLETHQYSVTSHKRSLHGGNDAAEGHKERVHAEGGIPGVFFNYDISPMKVVNREVRPKTFTGFLTGVCAVIGGTLTVAAAVDRFLYEGSRRMRKSAAHTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHN4</accession>
    <name>B8MHN4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein CFT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cleavage factor two protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Protein cft1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSTA_011240</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Involved in poly(A) site recognition. May be involved in coupling transcription termination and mRNA 3'-end formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CFT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483249.1">
        <property type="nucleotide sequence ID" value="XM_002483204.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="B8MHN4">
        <property type="interactions" value="1133"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MHN4"/>
    <dbReference type="GeneID" id="8109897"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_011240"/>
    <dbReference type="eggNOG" id="KOG1896">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002414_2_1_1"/>
    <dbReference type="InParanoid" id="B8MHN4"/>
    <dbReference type="OMA" id="PMTKFKL"/>
    <dbReference type="OrthoDB" id="6109at2759"/>
    <dbReference type="PhylomeDB" id="B8MHN4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000625">
        <property type="entry name" value="mRNA cleavage and polyadenylation factor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000788">
        <property type="entry name" value="mRNA cleavage and polyadenylation factor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
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        </source>
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    <sequence length="1382" mass="150727" checksum="069D6A33CDDED5E2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHV6</accession>
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        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    </dbReference>
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            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
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        <location>
            <begin position="10"/>
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    </feature>
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            <begin position="20"/>
            <end position="29"/>
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            <end position="52"/>
        </location>
    </feature>
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            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="136" mass="15005" checksum="0EF5D91ED671ACA4" modified="2009-03-03" version="1">MASEKKSDAQVLLELVQGQLERHNTRSEKEEDTMIGTEKASTNDSTATTTLPKNPENDQQKEPKIPAQPLYPILNCGCLNSRELPTTAGHVDIGYVPYITNQFNSLSDIGLYGAAYQAVEVNDTSPIFHTTRQNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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            </authorList>
            <dbReference type="PubMed" id="25676766"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    <dbReference type="PhylomeDB" id="B8MIA8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="AMO1_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21099">
        <property type="entry name" value="RAD201"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SI:CH211-113E8.11"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
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        <location>
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            <end position="25"/>
        </location>
    </feature>
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            <end position="404"/>
        </location>
    </feature>
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            <end position="239"/>
        </location>
    </feature>
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            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
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        <location>
            <begin position="302"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED14592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="524" mass="55218" checksum="BDFCE4ED4DE53880" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIJ7</accession>
    <name>B8MIJ7_TALSN</name>
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        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">TSTA_045510</name>
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        <name type="synonym">Penicillium stipitatum</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="InParanoid" id="B8MIJ7"/>
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    <dbReference type="PhylomeDB" id="B8MIJ7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:aspartic-type endopeptidase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
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        <property type="entry name" value="RNaseH_sf"/>
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        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
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        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="5">
        <location>
            <begin position="315"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="6">
        <location>
            <begin position="598"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="327"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="883"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="906"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="922"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="932"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="965"/>
            <end position="974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED15089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1499" mass="171451" checksum="35D832E7C08236D8" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIQ0</accession>
    <name>B8MIQ0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_050000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002485470.1"/>
    </dbReference>
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    <dbReference type="STRING" id="441959.B8MIQ0"/>
    <dbReference type="GeneID" id="8108764"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_050000"/>
    <dbReference type="eggNOG" id="KOG0787">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_023861_5_1_1"/>
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    <dbReference type="OMA" id="NEMPSIC"/>
    <dbReference type="OrthoDB" id="241648at2759"/>
    <dbReference type="PhylomeDB" id="B8MIQ0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="[Pyruvate dehydrogenase (Acetyl-transferring)] kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="318"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="109"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED15562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="452" mass="51390" checksum="587523D092B7A04A" modified="2009-03-03" version="1">MWKASDKLMATIKHYASFPATGVSLRQMVQFGETPSPGTLFRASQFLSEELPIRLAHRVEELNHLPDGLNEMPSIKKVKDWYAQSFEEIINVPKPSLSDEVKAHLIRPMRNHKKDSKPLSETTWNPSIREGQYRSSPDSAITANGKENRDPNHKGTNGNGKAKLTLSRRYFVPADDYADWPPEIDAYNQRFKRTLQQIKRRHDGVVTTVAQGILEYKRKRQRLQIDSSIQAFLDRFYMSRIGIRMLIGQHIALTEQTHAHHPNYVGIICTKTNIHEVATEAIENARFVCEDHYGLFEAPKVQLICKPDLNFMYVPGHLSHMLFETLKNSLRAVVETHGAEKEEFPVTKVIVAEGREDITIKISDEGGGIPRSSIPLVWTYMYTTVDQTPSLDPDFDKSDFKAPMAGFGYGLPISRLYARYFGGDLKLISMEGYGTDVYLHLNRLSSSSEPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJA6</accession>
    <name>B8MJA6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_041720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484648.1">
        <property type="nucleotide sequence ID" value="XM_002484603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJA6"/>
    <dbReference type="STRING" id="441959.B8MJA6"/>
    <dbReference type="GeneID" id="8102949"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_041720"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012997_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJA6"/>
    <dbReference type="OMA" id="FIGHQEI"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="PhylomeDB" id="B8MJA6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
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        <property type="entry name" value="CorA"/>
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        <property type="entry name" value="Ankyrin repeat"/>
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        <property type="entry name" value="ANK_REPEAT"/>
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    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="4">
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="920" mass="103800" checksum="B4442A06A2B29128" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJE1</accession>
    <name>B8MJE1_TALSN</name>
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        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">TSTA_045960</name>
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    <organism evidence="24 25">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.</text>
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    <comment type="catalytic activity">
        <reaction evidence="12 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
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            <dbReference type="ChEBI" id="CHEBI:140395"/>
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        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0005666">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
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        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
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        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
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        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb2_3"/>
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        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
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        <property type="entry name" value="PRK09606.1"/>
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        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
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    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb2_1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb2_3"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15 24" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="20">
        <location>
            <begin position="103"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="255"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="513"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="22">
        <location>
            <begin position="614"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="23">
        <location>
            <begin position="695"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="17">
        <location>
            <begin position="742"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="1117"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1095"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1097"/>
            <end position="1109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053978"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EED15141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1212" mass="135606" checksum="136AB5A5C531C943" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJH4</accession>
    <name>B8MJH4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_046280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485127.1">
        <property type="nucleotide sequence ID" value="XM_002485082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJH4"/>
    <dbReference type="GeneID" id="8099539"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_046280"/>
    <dbReference type="eggNOG" id="ENOG502RAZX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2868398_0_0_1"/>
    <dbReference type="InParanoid" id="B8MJH4"/>
    <dbReference type="OrthoDB" id="4361146at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="64" mass="7004" checksum="372292D30AB25D2F" modified="2009-03-03" version="1">MPHKLSDYSDSNSTSTVSSTDRIPVGEISDASRRSGPKLVVVHNGGGPSYDDKRPASWDKSRWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJW4</accession>
    <name>B8MJW4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleosome-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_042550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484734.1">
        <property type="nucleotide sequence ID" value="XM_002484689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJW4"/>
    <dbReference type="STRING" id="441959.B8MJW4"/>
    <dbReference type="GeneID" id="8103348"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_042550"/>
    <dbReference type="eggNOG" id="ENOG502SP6A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079693_0_1_1"/>
    <dbReference type="InParanoid" id="B8MJW4"/>
    <dbReference type="OMA" id="AWEKMSD"/>
    <dbReference type="OrthoDB" id="3360421at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED14781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="268" mass="30679" checksum="B05CA735CC8EB9FD" modified="2009-03-03" version="1">MPARDKYTEPQLRDQIKEEIHASDKGGRPGQWSARKAQMMASEYKKRGGSYTTDKETGQDESQKHLSNWTEEKWQTKEGEANATKYDGTKKRYLPKEAWEKMSEEEKEETERKKEEGEKQGKQYVGNTERAREERRRTSKGGAGSKDKDEGKDEDGEIEAKDVSKNKRAGPRKNKDADAKNESEDGDNEDGAQHEEEGENEEDVQEDGDFVEDAEANQDDEDDDIVDGDNEKEEPHGQKRVHTRQDDKTESKKQKTTSKNEEDGGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-09-13" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKB0</accession>
    <name>B8MKB0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_047160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485218.1">
        <property type="nucleotide sequence ID" value="XM_002485173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKB0"/>
    <dbReference type="GeneID" id="8098509"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_047160"/>
    <dbReference type="HOGENOM" id="CLU_1595656_0_0_1"/>
    <dbReference type="InParanoid" id="B8MKB0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877561" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED15265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="18572" checksum="297E09F1092B1688" modified="2009-03-03" version="1">MKAATAFLTSLAALASAQLIDLETGKKVSIADYSLLMPVAVREPEDNSTGLEPRDWYGVKGYFYSPNCGKDGSWDGYTWTNIGSGCYGSWENNQVKDLWSVEWGVLDDLKKKVYCTDPYFKLYLQLFHGCTNCNCGFEPNNNEMDGNYGCAKLGESIKSWRLACAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKV4</accession>
    <name>B8MKV4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumarylacetoacetate hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_044200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484906.1">
        <property type="nucleotide sequence ID" value="XM_002484861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKV4"/>
    <dbReference type="STRING" id="441959.B8MKV4"/>
    <dbReference type="GeneID" id="8102719"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_044200"/>
    <dbReference type="eggNOG" id="KOG1535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_2_1_1"/>
    <dbReference type="InParanoid" id="B8MKV4"/>
    <dbReference type="OMA" id="TCAGVGY"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="PhylomeDB" id="B8MKV4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF100">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G01490)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="84"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED14953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="296" mass="32317" checksum="4CC829C8D57AB7EE" modified="2009-03-03" version="1">MKVVWERLIRFVATDGRTLYGEPILLSPDFDLGTTTAEIKLQAKVIVGSDIYDETGATRITDEVVTVQKLLGPLTQEDVPILRCVGLNYKTHIQETGRSPPPTPSIFFKPNTTITDHDCNVVIPKIAQDEQADYEGELCLVIGKDAKNVTKEVALDYVAALTVGNDISSRKLQIDRTIAGPVPQWGFSKGFDTFAPLGPCLVRRDVVGDETQLRLQTIIDGEVRQDTLISDLLFGCAELVSYLSTGTTLQKGSVIMTGTPGGVGNGLKPPKFLRPGNRMEVRVSKIGTLRNGVEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLA9</accession>
    <name>B8MLA9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">T-complex protein 1, theta subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_044880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484977.1">
        <property type="nucleotide sequence ID" value="XM_002484932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLA9"/>
    <dbReference type="FunCoup" id="B8MLA9">
        <property type="interactions" value="1517"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MLA9"/>
    <dbReference type="GeneID" id="8104164"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_044880"/>
    <dbReference type="eggNOG" id="KOG0362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_4_2_1"/>
    <dbReference type="InParanoid" id="B8MLA9"/>
    <dbReference type="OMA" id="WGLKYAV"/>
    <dbReference type="OrthoDB" id="1748577at2759"/>
    <dbReference type="PhylomeDB" id="B8MLA9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03341">
        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="473"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="481"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED15024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="581" mass="63136" checksum="0686307CFD315E19" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLP2</accession>
    <name>B8MLP2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_101450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486143.1">
        <property type="nucleotide sequence ID" value="XM_002486098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLP2"/>
    <dbReference type="STRING" id="441959.B8MLP2"/>
    <dbReference type="GeneID" id="8101833"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_101450"/>
    <dbReference type="HOGENOM" id="CLU_1441957_0_0_1"/>
    <dbReference type="InParanoid" id="B8MLP2"/>
    <dbReference type="OrthoDB" id="3799328at2759"/>
    <dbReference type="PhylomeDB" id="B8MLP2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED13905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="188" mass="20603" checksum="28E1DD8A8E627A80" modified="2009-03-03" version="1">MLGISLPSGEMQDIVMRKAYKNASLDASGTDYVECHEHLLTVSTNGVPVNGAMNGDTNGFKTNATPIIGVQENGTEDQQKFLLMPMSAASTNSLKLLVQQISNTVLQSGDIGTLQSIAHTLFKCRDYLRYWKHTVTEDDAPSKGTVDPLLFAFVFTGQGAQYPGMGKELVSQSQHFRNTIRDRGSWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8MME6</accession>
    <name>B8MME6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hexose transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_099520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485938.1">
        <property type="nucleotide sequence ID" value="XM_002485893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MME6"/>
    <dbReference type="GeneID" id="8105395"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_099520"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="InParanoid" id="B8MME6"/>
    <dbReference type="OMA" id="IPQWEEY"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="PhylomeDB" id="B8MME6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF52">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="29"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED13700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="505" mass="56773" checksum="3061C59CC8D4B0E6" modified="2009-03-03" version="1">MTKATFERFSNNTNPKWWKDACLRMNVFYCIGCMMCPVYLGYDQSLLVGLQALPRWKEYFHSPSGPMLGLITSSIMLPAIVFGFPASWICMRWGHRWAIMTGCILTIVGAIWNALSLSRTHFIVSRLIAGAGGTISKVGAPALLHETAHPRLRSPLGYMYFACYYIGSILSSIMSTIGLYIEAPESPRFMVSKGHNQKALAMLARHHANGDENDALVKWELQEIESSLEDEAQNHKSSYLDFLRTKGNRKRLAVAAAFAIGANWLGNGIVSYYFTPVLTSVGVKKPIQILSVNLGLNIWNLILAQYAGFNIDRFGRRPLLFAATVGMIFSYSFVMGFSAGFAETGSKALGICAIPFLFFFFGFYDVAWTPLNYSYATEIMPYHLRTKGLAIYNTIQQLGNSFNQFVNPIALQAITWKYYGVYIAVECLYVVLIYFFFPETKKLSIEEVALVFDYGMKDGRVKAAANFRDEFVDGGDVLKQVPKVEHKEFLEKHECNGGTIRENRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMX0</accession>
    <name>B8MMX0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_101590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486157.1">
        <property type="nucleotide sequence ID" value="XM_002486112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMX0"/>
    <dbReference type="STRING" id="441959.B8MMX0"/>
    <dbReference type="GeneID" id="8101847"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_101590"/>
    <dbReference type="HOGENOM" id="CLU_2499408_0_0_1"/>
    <dbReference type="InParanoid" id="B8MMX0"/>
    <dbReference type="OrthoDB" id="3358371at2759"/>
    <dbReference type="PhylomeDB" id="B8MMX0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="86" mass="9534" checksum="7092353DF5C6CDBF" modified="2009-03-03" version="1">MWPWLVLKVIPQRVLTDKGAEITAANLNDKDSLVKAFQGAIVIFAVTNFFESAMQLGVEEGKKVEFAQATNMINAAKDIPTLEHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMX4</accession>
    <name>B8MMX4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_101630</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486161.1">
        <property type="nucleotide sequence ID" value="XM_002486116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMX4"/>
    <dbReference type="FunCoup" id="B8MMX4">
        <property type="interactions" value="430"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MMX4"/>
    <dbReference type="GeneID" id="8101851"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_101630"/>
    <dbReference type="eggNOG" id="ENOG502QPVP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011455_1_1_1"/>
    <dbReference type="InParanoid" id="B8MMX4"/>
    <dbReference type="OMA" id="LQTWVIC"/>
    <dbReference type="OrthoDB" id="2341546at2759"/>
    <dbReference type="PhylomeDB" id="B8MMX4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000003">
        <property type="entry name" value="C6 transcription factor (Leu3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF21">
        <property type="entry name" value="REGULATORY PROTEIN LEU3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="90"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="52"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED13923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="709" mass="78789" checksum="F88AF49293455291" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>B8MN40</accession>
    <name>B8MN40_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">O-acetylhomoserine sulfhydrylase, putative</fullName>
            <ecNumber evidence="7">2.5.1.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_102190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.49" evidence="7"/>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486227.1">
        <property type="nucleotide sequence ID" value="XM_002486182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MN40"/>
    <dbReference type="STRING" id="441959.B8MN40"/>
    <dbReference type="GeneID" id="8099264"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_102190"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_4_0_1"/>
    <dbReference type="InParanoid" id="B8MN40"/>
    <dbReference type="OMA" id="GFHNMVF"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="PhylomeDB" id="B8MN40"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003961">
        <property type="term" value="F:O-acetylhomoserine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071269">
        <property type="term" value="P:L-homocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000035">
        <property type="entry name" value="O-succinylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797">
        <property type="entry name" value="HOMOCYSTEINE/CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797:SF2">
        <property type="entry name" value="HOMOCYSTEINE_CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED13989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="473" mass="51126" checksum="5671E1B7E5D3BF7A" modified="2009-03-03" version="1">MPVSGSLKDVTKAPSWTTVSLHGGQEPDPVNGSRAVPLYQTAAYNFSDAADGASKFAWSKDGYVYTRMGNPTNSVFETRMSMLEGGVGAVATASGHAAQFMAITNCCSPGQNFVSTSWLYGGTYNQFRVYMKKFNIDVKWVHGNDPAEVDKAIDENTRAVYIETISNPKHSVPDIEAIAAVAHKHGIPLIVDNTFGMGGYLARPLTLGADIVTHSCTKWIGGHGTSMGGIVIDGGHFDWSASGKFPGFTEPADGYHGLRFWETYGYKALAAKLRMDSMRDLGPCMSPFNAWLFLQGLETLSLRGKRHCETTLALAEWLEAHPSINWVLYPGLKSHPDYEHVRKIMPNGAGGVLTFGVAGSVEEVRAVVNNLKLCSHLANVGDAKTLIIHPWVTTHQQLPDEEKIKGGVTPDLIRLSVGLEDFEDIKHDFEQAFIAAGLKPATKNGDPFAKALALVKDGFMKDLGTGAPKPIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNT5</accession>
    <name>B8MNT5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_103930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486412.1">
        <property type="nucleotide sequence ID" value="XM_002486367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNT5"/>
    <dbReference type="STRING" id="441959.B8MNT5"/>
    <dbReference type="GeneID" id="8103165"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_103930"/>
    <dbReference type="eggNOG" id="ENOG502SQY2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_6_3_1"/>
    <dbReference type="InParanoid" id="B8MNT5"/>
    <dbReference type="OMA" id="PNPRWYL"/>
    <dbReference type="OrthoDB" id="4364638at2759"/>
    <dbReference type="PhylomeDB" id="B8MNT5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="33"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED14174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="122" mass="14539" checksum="301ABECA1D65C472" modified="2009-03-03" version="1">MQIYDVFTLEKLRCVSSTKPLRGQILERAKPVEINKKILDSKMRWNKLHYQVKWLGYDPNPRWYLAANFKNAPRQLKSFHNRYPEKPGPPVNLQRWIEAAERDEFVNDDRKDNAIEELEPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8MP24</accession>
    <name>B8MP24_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_104770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486501.1">
        <property type="nucleotide sequence ID" value="XM_002486456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MP24"/>
    <dbReference type="STRING" id="441959.B8MP24"/>
    <dbReference type="GeneID" id="8098698"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_104770"/>
    <dbReference type="eggNOG" id="ENOG502RS5Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_490172_0_0_1"/>
    <dbReference type="InParanoid" id="B8MP24"/>
    <dbReference type="OMA" id="TIMVENC"/>
    <dbReference type="OrthoDB" id="4225352at2759"/>
    <dbReference type="PhylomeDB" id="B8MP24"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="6">
        <location>
            <begin position="420"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED14263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="556" mass="64444" checksum="0382C836DC0791D9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MP69</accession>
    <name>B8MP69_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vesicle-mediated transport protein (Imh1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_105200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486546.1">
        <property type="nucleotide sequence ID" value="XM_002486501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MP69"/>
    <dbReference type="FunCoup" id="B8MP69">
        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MP69"/>
    <dbReference type="GeneID" id="8098741"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_105200"/>
    <dbReference type="eggNOG" id="ENOG502S0A5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002906_0_0_1"/>
    <dbReference type="InParanoid" id="B8MP69"/>
    <dbReference type="OMA" id="NIGQDHV"/>
    <dbReference type="OrthoDB" id="1926336at2759"/>
    <dbReference type="PhylomeDB" id="B8MP69"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051952">
        <property type="entry name" value="Golgi-autophagy_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157:SF25">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01465">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00755">
        <property type="entry name" value="Grip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="7">
        <location>
            <begin position="1112"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="508"/>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1042"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="31"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="77"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="95"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED14308.1"/>
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    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
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    <sequence length="1166" mass="132744" checksum="5E751F8A22C9E7C0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPF4</accession>
    <name>B8MPF4_TALSN</name>
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        <submittedName>
            <fullName evidence="13">Polyketide synthase, putative</fullName>
            <ecNumber evidence="13">2.3.1.161</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_106020</name>
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    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
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        <property type="nucleotide sequence ID" value="XM_002486586.1"/>
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    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0050637">
        <property type="term" value="F:lovastatin nonaketide synthase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0031177">
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        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
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    </dbReference>
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    <proteinExistence type="predicted"/>
    <keyword evidence="8 13" id="KW-0012">Acyltransferase</keyword>
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    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="4"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
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        <location>
            <begin position="2431"/>
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        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="9">
        <location>
            <begin position="955"/>
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        </location>
    </feature>
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        <location>
            <begin position="1105"/>
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        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="9">
        <location>
            <position position="987"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="9">
        <location>
            <position position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
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    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED14393.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="2515" mass="275859" checksum="F6822E6F00A5566E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MPN3</accession>
    <name>B8MPN3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_106820</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486710.1">
        <property type="nucleotide sequence ID" value="XM_002486665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MPN3"/>
    <dbReference type="STRING" id="441959.B8MPN3"/>
    <dbReference type="GeneID" id="8103582"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_106820"/>
    <dbReference type="HOGENOM" id="CLU_943916_0_0_1"/>
    <dbReference type="InParanoid" id="B8MPN3"/>
    <dbReference type="OrthoDB" id="2398441at2759"/>
    <dbReference type="PhylomeDB" id="B8MPN3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="188"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="194"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="141"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED14472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="29878" checksum="4B0D8A89BDCC715A" modified="2009-03-03" version="1">METQQQPALVQIDDSHIPDFTYEAEEEHATEGPAQIIIDSPPSTIPFDEDSPPRQLPSERLPPSEEVGEAAGSPSPVIEISDDEEENHRRPRRRNTGRRPDYTYRDYQDTMEHAISAPPLRKRKREDSDVVDFRSKIKQFVKEITEPYEALEKENKRLTEERHQWKKDKKQLQLQIQYLQRQVNEQKRRNILKCVLCHRTFNESWKVLGCGHTLCKNCVEDIKSKGSLFEYPCPYPECKKPIRSCLDFYPNVVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQ49</accession>
    <name>B8MQ49_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell wall biogenesis protein/glutathione transferase (Gto1), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_055750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487186.1">
        <property type="nucleotide sequence ID" value="XM_002487141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQ49"/>
    <dbReference type="FunCoup" id="B8MQ49">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MQ49"/>
    <dbReference type="GeneID" id="8102268"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_055750"/>
    <dbReference type="eggNOG" id="KOG2903">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037263_0_1_1"/>
    <dbReference type="InParanoid" id="B8MQ49"/>
    <dbReference type="OMA" id="PWANRAI"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="PhylomeDB" id="B8MQ49"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000162">
        <property type="entry name" value="Glutathione S-transferase Gst3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01148">
        <property type="entry name" value="Xi_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="206"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="161"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="179"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="3">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="3">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED13075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="370" mass="42379" checksum="CBE063198CBA5F32" modified="2009-03-03" version="1">MSFALLRLRTAFAISNKASVSISATILYGTRTMSTGNKNPITEWVSRDSKTGEFKRGVSQFRSFISSEPGAEFPPEKGRYHLYVSYACPWAHRTLITRKLKGLEDIISVTAVHWHMAEKGWRFVTPGENVPGENVRPDPIHPGFTHLRDIYFDVDPEYTGRFTVPTLFDTKTKRIVSNESSEIIRMFYHEFDSLLPEQYAKIDLFPESLRAEIESSNDWIYNDINNGVYKSGFATTQEAYEKAVRTLFAALDKVEAHLASRQASGKEYMYGDHISESDIRLYTTIIRFDAVYVQHFKTNLRDIRSGYPAIHRWVRHLYWDIPAFGETTQFEHIKKHYTKSHGQINPFGITPVGPIPDVLPKGEEVAAVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQK9</accession>
    <name>B8MQK9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_058980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487522.1">
        <property type="nucleotide sequence ID" value="XM_002487477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQK9"/>
    <dbReference type="FunCoup" id="B8MQK9">
        <property type="interactions" value="1332"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MQK9"/>
    <dbReference type="GeneID" id="8106500"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_058980"/>
    <dbReference type="eggNOG" id="ENOG502QSY9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007426_0_2_1"/>
    <dbReference type="InParanoid" id="B8MQK9"/>
    <dbReference type="OMA" id="EPPEWRG"/>
    <dbReference type="OrthoDB" id="762982at2759"/>
    <dbReference type="PhylomeDB" id="B8MQK9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        </location>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="858" mass="95701" checksum="3E2428D23C694592" modified="2009-03-03" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
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            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED13092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="586" mass="65864" checksum="EDECCA8BA6B85F71" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRK2</accession>
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        <submittedName>
            <fullName evidence="3">Ubiquitin-protein ligase (Asi3), putative</fullName>
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        <name evidence="3" type="ORF">TSTA_056600</name>
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    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
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                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="441959.B8MRK2"/>
    <dbReference type="GeneID" id="8100723"/>
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    <dbReference type="eggNOG" id="ENOG502S2K4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006057_0_0_1"/>
    <dbReference type="InParanoid" id="B8MRK2"/>
    <dbReference type="OMA" id="ERMNVTP"/>
    <dbReference type="OrthoDB" id="66726at2759"/>
    <dbReference type="PhylomeDB" id="B8MRK2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="509"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="829"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="845"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED13159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1056" mass="118717" checksum="A9C1A7065C6A6C45" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8MS53</accession>
    <name>B8MS53_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">alcohol O-acetyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.84</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alcohol O-acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_004960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Displays enzymatic activity both for medium-chain fatty acid (MCFA) ethyl ester synthesis and hydrolysis (esterase activity). MCFA are toxic for yeast and this enzyme could thus be involved in their detoxification by esterification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aliphatic alcohol + acetyl-CoA = an acetyl ester + CoA</text>
            <dbReference type="Rhea" id="RHEA:17229"/>
            <dbReference type="ChEBI" id="CHEBI:2571"/>
            <dbReference type="ChEBI" id="CHEBI:47622"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.84" evidence="6"/>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488112.1">
        <property type="nucleotide sequence ID" value="XM_002488067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MS53"/>
    <dbReference type="FunCoup" id="B8MS53">
        <property type="interactions" value="270"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MS53"/>
    <dbReference type="ESTHER" id="talsn-b8ms53">
        <property type="family name" value="abh_upf0017"/>
    </dbReference>
    <dbReference type="GeneID" id="8104480"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_004960"/>
    <dbReference type="eggNOG" id="KOG1838">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032487_1_0_1"/>
    <dbReference type="InParanoid" id="B8MS53"/>
    <dbReference type="OMA" id="MMTTSWG"/>
    <dbReference type="OrthoDB" id="5954035at2759"/>
    <dbReference type="PhylomeDB" id="B8MS53"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004026">
        <property type="term" value="F:alcohol O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000137">
        <property type="entry name" value="EEB1p Acyl-coenzymeA:ethanol O-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="9">
        <location>
            <begin position="149"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00080774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED12458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="464" mass="51583" checksum="635EBF3D056B0E31" modified="2009-03-03" version="1">MSLLSRFSPQAKISLVHCEENQVLLTAKHHTKSETEKQIKLIDICREATPSTCNLNPLLFNGHLQTGWTTIKETNEIPIYYKRKIFEQEIPSLAGQFAVDFVVPAYPKTTGPEATDEARKYTLPSGLPARTAFFSQEELAALPSDDTKPMLVALHGLTGGSHEVYLRAALAPLVLDRESGWEACVVNGRGCAQTKLSTPLLFNGRATWDVRQVVKWLRKTFPNRPLFGIGFSLGANIMVNYLAEEGENCLLNAAVICANPWNLDATNLALRTSWLGSEVYSAHMAVSLVNLFNQHVDELIHHPRLKVDAMKDVKYIHEFDRAVQCPLWGYPTEGAYHRDASSTDSLLAIRIPFLAINAEDDPISVKAAIPYDEFKQTPYGVLLTTSWGGHLGWFELGGCRWFTKPATNFLDLMAKTIDFSVTPKPEKGKEGLYGESLANGSIHKPPQVPVFYPVNRKLSMTIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSI1</accession>
    <name>B8MSI1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_000810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487663.1">
        <property type="nucleotide sequence ID" value="XM_002487618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSI1"/>
    <dbReference type="STRING" id="441959.B8MSI1"/>
    <dbReference type="GeneID" id="8108704"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_000810"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_987575_0_0_1"/>
    <dbReference type="InParanoid" id="B8MSI1"/>
    <dbReference type="OrthoDB" id="4365515at2759"/>
    <dbReference type="PhylomeDB" id="B8MSI1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF25">
        <property type="entry name" value="RNASE H TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="3">
        <location>
            <begin position="110"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED12009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="282" mass="31217" checksum="5F70AB91558B1441" modified="2009-03-03" version="1">MNYTHTHTHTVTESLKDKVHLRTLGTVQRTALIRILSAFKTVSTAALEVESCILPTHLRLKQSAQIVAARLSTLPDDHPGCVVVRTPAFLEIDIEPDHDKAKHKASALQDTAGIAVFSDASGQHNHLGAAAVALDRNNNVIQQRKVSIGSMEYWSVYAAKLMAIYYAISLVLKIAMETRQAMTDRQEPATILSDSMSVLQALSNARNKLGQRIIQAVQQSVQELQTQGIPLRLQWVPGHCGDLGNEAADRLAKEAMGPEKEHPFQHLLSREKGFIRNRIQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MSW3</accession>
    <name>B8MSW3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_000940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487676.1">
        <property type="nucleotide sequence ID" value="XM_002487631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MSW3"/>
    <dbReference type="STRING" id="441959.B8MSW3"/>
    <dbReference type="GeneID" id="8108717"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_000940"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001650_6_0_1"/>
    <dbReference type="InParanoid" id="B8MSW3"/>
    <dbReference type="OMA" id="ACHEATI"/>
    <dbReference type="OrthoDB" id="4356562at2759"/>
    <dbReference type="PhylomeDB" id="B8MSW3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF438">
        <property type="entry name" value="REVERSE TRANSCRIPTASE TY1_COPIA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED12022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="30342" checksum="3E095DF3661F060C" modified="2009-03-03" version="1">MDKFEWFLNMRILRDREQQKIWICQDSYITKIAKKFGLTYGLVKTPISVDIKPFDGKATNQDIYHYQEMVGSVMYAAVITRIDIAKAVNKLAKHATNPSPIHIQQIKQVIQYLFNIRFLAIEYSPLRKSESDVVVCASDASFRDNIDCISSEGYLIQLYNGPVDWKATKQRYVTTSTTKAELRVVTEAVKRFPEPNFYTSLRHIDIYHHWLHQEIQSKQLHIQWVDTKRMVADGLTKLLKGQIFVNWRKHQGLVDIAHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTE2</accession>
    <name>B8MTE2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">General transcription and DNA repair factor IIH subunit TFB5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_002530</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="function">
        <text evidence="9">In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the 7-subunit TFIIH core complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TFB5 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487841.1">
        <property type="nucleotide sequence ID" value="XM_002487796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTE2"/>
    <dbReference type="FunCoup" id="B8MTE2">
        <property type="interactions" value="143"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MTE2"/>
    <dbReference type="GeneID" id="8102864"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_002530"/>
    <dbReference type="eggNOG" id="ENOG502SBQE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166246_3_2_1"/>
    <dbReference type="InParanoid" id="B8MTE2"/>
    <dbReference type="OMA" id="IYNPMDE"/>
    <dbReference type="OrthoDB" id="354at2759"/>
    <dbReference type="PhylomeDB" id="B8MTE2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006294">
        <property type="term" value="P:nucleotide-excision repair, preincision complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1220:FF:000002">
        <property type="entry name" value="RNA polymerase II transcription factor B subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1220">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035935">
        <property type="entry name" value="TFB5-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009400">
        <property type="entry name" value="TFIIH_TTDA/Tfb5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06331">
        <property type="entry name" value="Tfb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01395">
        <property type="entry name" value="Tbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142897">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED12187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="69" mass="8033" checksum="87B9743054C701BF" modified="2009-03-03" version="1">MPRAVKGVLVECDPSVKAIILKYDEERHDYIVEDLDDDRHLVIKESQLQNLKERLGQVSFSSFCALSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8MU45</accession>
    <name>B8MU45_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Alkaline serine protease AorO, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_006950</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="9">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488332.1">
        <property type="nucleotide sequence ID" value="XM_002488287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MU45"/>
    <dbReference type="STRING" id="441959.B8MU45"/>
    <dbReference type="MEROPS" id="S53.007"/>
    <dbReference type="GeneID" id="8106828"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_006950"/>
    <dbReference type="eggNOG" id="ENOG502QTN1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013783_4_0_1"/>
    <dbReference type="InParanoid" id="B8MU45"/>
    <dbReference type="OMA" id="FELANCD"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="PhylomeDB" id="B8MU45"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF19">
        <property type="entry name" value="SERINE PROTEASE AORO, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877770" evidence="10">
        <location>
            <begin position="25"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="11">
        <location>
            <begin position="235"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="573"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="614"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="615"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="633"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="635"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED12678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="655" mass="70319" checksum="B251E59D839EE58D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUB1</accession>
    <name>B8MUB1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD-repeat protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_108050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488371.1">
        <property type="nucleotide sequence ID" value="XM_002488326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUB1"/>
    <dbReference type="STRING" id="441959.B8MUB1"/>
    <dbReference type="GeneID" id="8106869"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_108050"/>
    <dbReference type="eggNOG" id="KOG4155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_6_16_1"/>
    <dbReference type="InParanoid" id="B8MUB1"/>
    <dbReference type="OMA" id="YRRINTH"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="PhylomeDB" id="B8MUB1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035097">
        <property type="term" value="C:histone methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
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        <property type="match status" value="2"/>
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        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
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        <location>
            <begin position="73"/>
            <end position="232"/>
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        <source>
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        </source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED11615.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1180" mass="131432" checksum="2CEBA6E431189C9D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUD5</accession>
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        <name evidence="2" type="ORF">TSTA_108270</name>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
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        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED11639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="669" mass="74164" checksum="3D4EEA1A853351D0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUG8</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="1" type="ORF">TSTA_110200</name>
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    <organism evidence="1 2">
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
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    <dbReference type="PhylomeDB" id="B8MUG8"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="167" mass="19403" checksum="554C74735CA5DE2E" modified="2009-03-03" version="1">MLWLPTIMAENSESKLKPTSNIPGADIPTYIKDRDDECPHLLGDFENFITSILEPHKNRILLRNKHAPHSDLMPTLNRLSHRLLKLVSLTTGQAHPSCPESVLRYHLLTSSQLDDLARYYHQIWPPTPETYQYPKIIIPWIGTEEQDTIDIETKRERIGRFIGLRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUR8</accession>
    <name>B8MUR8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_109860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002488517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUR8"/>
    <dbReference type="GeneID" id="8107218"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109860"/>
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    <dbReference type="InParanoid" id="B8MUR8"/>
    <dbReference type="OrthoDB" id="4207519at2759"/>
    <dbReference type="PhylomeDB" id="B8MUR8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="216" mass="25323" checksum="A09F0579B75F7CFA" modified="2009-03-03" version="1">MPPILNKNKKDLAEQEGRILLAISDLKNERILRVAQAARIYKIPRTTLQKRLSGTQQRSQIRANSHKLTQFEEESLVKWILDLDKRGLPPRHSLVGEKWVYNLVKRRLEIESKFSRKYDYEQYFDRVRKVILEYGILPEDIYNFDETGFAMGLCATAKVITGSDRYTWPKLLQPGDREWVTAIEAVNSTGWALPSYIIFKAKKYMWLGWFEDLPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUV5</accession>
    <name>B8MUV5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endonuclease/reverse transcriptase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_110530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488629.1">
        <property type="nucleotide sequence ID" value="XM_002488584.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MUV5"/>
    <dbReference type="GeneID" id="8107285"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_110530"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_23_0_1"/>
    <dbReference type="InParanoid" id="B8MUV5"/>
    <dbReference type="OMA" id="WLEYELR"/>
    <dbReference type="OrthoDB" id="3561817at2759"/>
    <dbReference type="PhylomeDB" id="B8MUV5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="954"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="3">
        <location>
            <begin position="1442"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED11873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1744" mass="192205" checksum="D7B5B2E2BF92651E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>H9CNN2</accession>
    <name>H9CNN2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">ATP synthase subunit 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_m0490</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="15"/>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="BMC Genomics" volume="13" first="698" last="698">
            <title>Sequencing of mitochondrial genomes of nine Aspergillus and Penicillium species identifies mobile introns and accessory genes as main sources of genome size variability.</title>
            <authorList>
                <person name="Joardar V."/>
                <person name="Abrams N.F."/>
                <person name="Hostetler J."/>
                <person name="Paukstelis P.J."/>
                <person name="Pakala S."/>
                <person name="Pakala S.B."/>
                <person name="Zafar N."/>
                <person name="Abolude O.O."/>
                <person name="Payne G."/>
                <person name="Andrianopoulos A."/>
                <person name="Denning D.W."/>
                <person name="Nierman W.C."/>
            </authorList>
            <dbReference type="PubMed" id="23234273"/>
            <dbReference type="DOI" id="10.1186/1471-2164-13-698"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="JQ354994">
        <property type="protein sequence ID" value="AFD95926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9CNN2"/>
    <dbReference type="FunCoup" id="H9CNN2">
        <property type="interactions" value="788"/>
    </dbReference>
    <dbReference type="STRING" id="441959.H9CNN2"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_m0490"/>
    <dbReference type="InParanoid" id="H9CNN2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18182">
        <property type="entry name" value="ATP-synt_Fo_c_ATP5G3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.20.10:FF:000003">
        <property type="entry name" value="Atp synthase f complex subunit mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031:SF0">
        <property type="entry name" value="ATPASE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0138">CF(0)</keyword>
    <keyword evidence="7 13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 13 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="14">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFD95926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="74" mass="7639" checksum="52735ACEA29F14D2" modified="2012-05-16" version="1">MLESSRLIATGLATTGLIGAGVGIGIVFGALILGVSRNPSLRGQLFNYAILGFAFSEATGLFALMMAFLLLYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8LT10</accession>
    <name>B8LT10_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Acylphosphatase</fullName>
            <ecNumber evidence="1 2">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_069390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>an acyl phosphate + H2O = a carboxylate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acylphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="1 2"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340905.1">
        <property type="nucleotide sequence ID" value="XM_002340864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LT10"/>
    <dbReference type="STRING" id="441959.B8LT10"/>
    <dbReference type="GeneID" id="8106165"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_069390"/>
    <dbReference type="eggNOG" id="KOG3360">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141932_4_0_1"/>
    <dbReference type="InParanoid" id="B8LT10"/>
    <dbReference type="OMA" id="VGFRWSM"/>
    <dbReference type="OrthoDB" id="7961613at2759"/>
    <dbReference type="PhylomeDB" id="B8LT10"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="ACYLPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268:SF4">
        <property type="entry name" value="ACYLPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00112">
        <property type="entry name" value="ACYLPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="Acylphosphatase/BLUF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00151">
        <property type="entry name" value="ACYLPHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="4">
        <location>
            <begin position="5"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED23518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="92" mass="10567" checksum="058C71B8433FA097" modified="2009-03-03" version="1">MALTRVRFKVHGTVQGVSFRAFTQKRAIEYGVTGWVQNSRDGRVEGEIQGEPELVQKLLKDVDKGPRHAQVVKLEKTDIETQEDEISFEIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8LTE9</accession>
    <name>B8LTE9_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rho GDP-dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_064900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340414.1">
        <property type="nucleotide sequence ID" value="XM_002340373.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340415.1">
        <property type="nucleotide sequence ID" value="XM_002340374.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340416.1">
        <property type="nucleotide sequence ID" value="XM_002340375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LTE9"/>
    <dbReference type="FunCoup" id="B8LTE9">
        <property type="interactions" value="461"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LTE9"/>
    <dbReference type="GeneID" id="8106205"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_064900"/>
    <dbReference type="eggNOG" id="KOG3205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076228_1_0_1"/>
    <dbReference type="InParanoid" id="B8LTE9"/>
    <dbReference type="OMA" id="YKPTAAK"/>
    <dbReference type="OrthoDB" id="1683373at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.30:FF:000001">
        <property type="entry name" value="Rho GDP-dissociation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980:SF3">
        <property type="entry name" value="LD16419P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00492">
        <property type="entry name" value="RHOGDI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED23027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="199" mass="22606" checksum="FAA25119BA3643E9" modified="2009-03-03" version="1">MPEHEDELSTSKTEGFKVGEKKTIEEYKNLDQNDESLNRWKASLGLNTGEPIGDPNDPRTCIIQSLAIETPGKPDITLDLTGPNALESLKDKPFTIKEGSKFFTKVVFQVHRDVLSGLKYVHVVKRKGITVTKDEEMLGSYAPNTTDKPTYEKRFHEEEAPSGMLARGHYTVRSRFVDDDGHIHLEFTWSFDIAKEWAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUF4</accession>
    <name>B8LUF4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal specific transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_071270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341114.1">
        <property type="nucleotide sequence ID" value="XM_002341073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUF4"/>
    <dbReference type="STRING" id="441959.B8LUF4"/>
    <dbReference type="GeneID" id="8106635"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_071270"/>
    <dbReference type="eggNOG" id="ENOG502S5RK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008828_1_0_1"/>
    <dbReference type="InParanoid" id="B8LUF4"/>
    <dbReference type="OMA" id="DEIGIMY"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="PhylomeDB" id="B8LUF4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED23727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="738" mass="81752" checksum="2112B389DB0CA4AE" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8LV95</accession>
    <name>B8LV95_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposable element tc3 transposase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_065980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340532.1">
        <property type="nucleotide sequence ID" value="XM_002340491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LV95"/>
    <dbReference type="STRING" id="441959.B8LV95"/>
    <dbReference type="GeneID" id="8102403"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_065980"/>
    <dbReference type="eggNOG" id="ENOG502QUTZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033666_0_1_1"/>
    <dbReference type="InParanoid" id="B8LV95"/>
    <dbReference type="OMA" id="HQNWTTE"/>
    <dbReference type="OrthoDB" id="4349822at2759"/>
    <dbReference type="PhylomeDB" id="B8LV95"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052338">
        <property type="entry name" value="Transposase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022:SF119">
        <property type="entry name" value="TC1-LIKE TRANSPOSASE DDE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022">
        <property type="entry name" value="TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13384">
        <property type="entry name" value="HTH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="2">
        <location>
            <begin position="104"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="3">
        <location>
            <begin position="160"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED23145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="355" mass="41420" checksum="3A226759D42F3572" modified="2009-03-03" version="1">MATPEPTSPPRATSAAALEPSDSRQNSARLNRDERIRVLTLRDAGFTYLQISQQLQISYRQVQYTCQSQQATPKKARGNPPKLSEAEVHHIIEWITSSKRTRQLNLSIGKHALARALKKRGYTRCKALNKPPLSDKHKQVRLAWALEHLNWTTEQWNRILWSDETWVTSGFHTRIWVTRKAGEELEGTCIRSSPARKRGWMFWATFHGNNKGPCLFWEKEWGTINSERYCQRVIPIIDGYIRLLRDDIWLQFMQDGAPGHASKETLEELHSRGIYPIYWPAFSPDLNPIEAVWNWMKDWIQEQYPDDEQLSYDRLREIVRAAWDALPEQFLKELIDSMHARCQAVIDARGGHTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8LVL3</accession>
    <name>B8LVL3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cx9C motif-containing protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_075170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341530.1">
        <property type="nucleotide sequence ID" value="XM_002341489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LVL3"/>
    <dbReference type="FunCoup" id="B8LVL3">
        <property type="interactions" value="113"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LVL3"/>
    <dbReference type="GeneID" id="8106211"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_075170"/>
    <dbReference type="eggNOG" id="ENOG502S7M4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2428556_0_0_1"/>
    <dbReference type="InParanoid" id="B8LVL3"/>
    <dbReference type="OMA" id="YQEEKCQ"/>
    <dbReference type="OrthoDB" id="13601at2759"/>
    <dbReference type="PhylomeDB" id="B8LVL3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027179">
        <property type="entry name" value="CMC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08991">
        <property type="entry name" value="CMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877252" description="Cx9C motif-containing protein 4, mitochondrial" evidence="2">
        <location>
            <begin position="21"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED24143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="91" mass="10262" checksum="0543E631D9ED8470" modified="2009-03-03" version="1">MILLMTLHVTLVLVPSRVSPLHLVPATSTDELPACLTKNSYNEEKCQAQIDALYECCNAFYQQRGEDAKTPSCPNASLLRVKMRQRAQQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B8LW48</accession>
    <name>B8LW48_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation initiation factor RLI1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-binding cassette sub-family E member RLI1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_074540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the multifactor complex (MFC) involved in translation initiation. Required for the binding of MFC to the 40S ribosome. Required for the processing and nuclear export of the 60S and 40S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341463.1">
        <property type="nucleotide sequence ID" value="XM_002341422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LW48"/>
    <dbReference type="FunCoup" id="B8LW48">
        <property type="interactions" value="1238"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LW48"/>
    <dbReference type="GeneID" id="8101130"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_074540"/>
    <dbReference type="eggNOG" id="KOG0063">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017344_4_1_1"/>
    <dbReference type="InParanoid" id="B8LW48"/>
    <dbReference type="OMA" id="MVCIQNG"/>
    <dbReference type="OrthoDB" id="6593433at2759"/>
    <dbReference type="PhylomeDB" id="B8LW48"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03236">
        <property type="entry name" value="ABC_RNaseL_inhibitor_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000144">
        <property type="entry name" value="ATP-binding cassette sub-family E member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000152">
        <property type="entry name" value="ATP-binding cassette, sub-family E, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034348">
        <property type="entry name" value="RLI_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009945">
        <property type="entry name" value="PRK13409.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="62"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="319"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00067238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00082546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED24076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="596" mass="67485" checksum="172AFB7061E514CC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWM5</accession>
    <name>B8LWM5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Fumarylacetoacetase</fullName>
            <ecNumber evidence="3 13">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSTA_077810</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="3 13"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341809.1">
        <property type="nucleotide sequence ID" value="XM_002341768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWM5"/>
    <dbReference type="STRING" id="441959.B8LWM5"/>
    <dbReference type="GeneID" id="8110249"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_077810"/>
    <dbReference type="eggNOG" id="KOG2843">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026207_2_0_1"/>
    <dbReference type="InParanoid" id="B8LWM5"/>
    <dbReference type="OMA" id="FGFGECR"/>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="PhylomeDB" id="B8LWM5"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01266">
        <property type="entry name" value="fum_ac_acetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF2">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 13 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="15">
        <location>
            <begin position="17"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="14">
        <location>
            <begin position="121"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EED24422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="412" mass="45108" checksum="B30FCD3C0F810019" modified="2009-03-03" version="1">MAFKISVSPDSPFTLDNIPFGVISTESNPQPRCATALGDYAIDLAAYWKDRTYAQLKGYRSLYAIFNQPSLNEFAALDSAIRSDVRTYLATEFAAGNIPERCAIPLKSVKLHLPMTIGGYVDFACSLEHCKNCAALTGGTISKNFYYAPLVYNGRTSSIVPSPEPVRRPHGILYDPETKQPTFCPSKNMDYELEMGCFISKPVLMGERISVENAANHIFGFVLLNDWSARDLQGFEMNPLGPFHSKGFGTSISPWIVTLDALLPFSCKPWHDHTGTEFEHQRHPDQTKASFDIRLEVTLLRNGVSHKITTSNLSYLYWTPYQQVAHYALAGCGLETGDLLGTGTITGESKNELGCLFEATLNGAKPIELANGDRLGFLKDGDEIILGASCGGGEGQPRLGFGECRGIILPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWP3</accession>
    <name>B8LWP3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-1,6-mannosyltransferase subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_078020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341827.1">
        <property type="nucleotide sequence ID" value="XM_002341786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWP3"/>
    <dbReference type="FunCoup" id="B8LWP3">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LWP3"/>
    <dbReference type="GeneID" id="8105642"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_078020"/>
    <dbReference type="eggNOG" id="KOG4748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021434_2_1_1"/>
    <dbReference type="InParanoid" id="B8LWP3"/>
    <dbReference type="OMA" id="DQDAYIM"/>
    <dbReference type="OrthoDB" id="205108at2759"/>
    <dbReference type="PhylomeDB" id="B8LWP3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000149">
        <property type="entry name" value="Alpha-1,6-mannosyltransferase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF10">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED24440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="325" mass="36794" checksum="CA66B190ACD9B723" modified="2009-03-03" version="1">MHHALPPRKSSKAPPFAPRTSVLSLQRRRQLKTIGIIALAVIFVLLVLSRFFSFSVSGPIGAVIPSGTANIVLVTLFDRQVLSEQYAEWIQNNREDYAARHGYATFFANASDYLYTLDEKTPRSWLQVPAVRHAMAENPHSTYFFFLDAHAFIMNPSLALATHVLEPKLLESLMIKDHSVVPPDSVIKTFSHLTSKDVDLIITQDGEDLVPGSFIIKQGPWAKFFLDLWFDPLYRSYNFARAEKHALDHIVQWHATILAKLALIPQRVINSYSKDSPDVSADGTYHDGDFIIHLNDCNAQGRSCEEELHPYYSVWQRKISSSKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWX8</accession>
    <name>B8LWX8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">feruloyl esterase</fullName>
            <ecNumber evidence="2">3.1.1.73</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_079660</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.73" evidence="2"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341998.1">
        <property type="nucleotide sequence ID" value="XM_002341957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LWX8"/>
    <dbReference type="STRING" id="441959.B8LWX8"/>
    <dbReference type="GeneID" id="8103905"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_079660"/>
    <dbReference type="eggNOG" id="ENOG502SBTI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_934393_0_0_1"/>
    <dbReference type="InParanoid" id="B8LWX8"/>
    <dbReference type="OMA" id="MITHYRI"/>
    <dbReference type="OrthoDB" id="424610at2759"/>
    <dbReference type="PhylomeDB" id="B8LWX8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043595">
        <property type="entry name" value="FaeB/C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050:SF2">
        <property type="entry name" value="FERULOYL ESTERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0858">Xylan degradation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED24611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="298" mass="32248" checksum="4B78A7D5A687B87B" modified="2009-03-03" version="1">MSHLFTDSIRLITASISDAVGLIYSGIIKILAGDVLSPRRLARMLFELVLGGLLLIAPAITDVQFLLSSNRTRSYWVHAPDNFQSGQTYPAVILFHGSGRLGSDADGLAMELDLRLSLPLVQTAYSADKYFIYPNGVGGAWAGPSYAEVSVPEDLQFVSDMINDLKSKYSIDSNRIYAAGMSNGGGFVGTLACSELGSRFAAFASVAGSFYTDVDGNGCLTSRSPLPFLEIHGGSDRGVHYSGGIGYGGPLPSIPVWYADTLPSYGSNRFYILRLIWAYLKVELLGREKQMYIQLNDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>B8LWY1</accession>
    <name>B8LWY1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Polyketide synthase, putative</fullName>
            <ecNumber evidence="10">2.3.1.161</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_079690</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.161" evidence="10"/>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002342001.1">
        <property type="nucleotide sequence ID" value="XM_002341960.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LWY1"/>
    <dbReference type="GeneID" id="8103913"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_079690"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_31_0_1"/>
    <dbReference type="InParanoid" id="B8LWY1"/>
    <dbReference type="OMA" id="RYPWQHG"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="PhylomeDB" id="B8LWY1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050637">
        <property type="term" value="F:lovastatin nonaketide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF13">
        <property type="entry name" value="POLYKETIDE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="8">
        <location>
            <begin position="26"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="9">
        <location>
            <begin position="949"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="2179"/>
            <end position="2256"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="949"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1113"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="981"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED24614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="2262" mass="248927" checksum="1D1E73D107CF1679" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXJ2</accession>
    <name>B8LXJ2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">COP9 signalosome subunit 7 (CsnG), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_078510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341880.1">
        <property type="nucleotide sequence ID" value="XM_002341839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXJ2"/>
    <dbReference type="STRING" id="441959.B8LXJ2"/>
    <dbReference type="GeneID" id="8109449"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_078510"/>
    <dbReference type="eggNOG" id="KOG3250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054426_0_0_1"/>
    <dbReference type="InParanoid" id="B8LXJ2"/>
    <dbReference type="OMA" id="QGWAGRC"/>
    <dbReference type="OrthoDB" id="10265275at2759"/>
    <dbReference type="PhylomeDB" id="B8LXJ2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF5">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22061">
        <property type="entry name" value="CSN7_HB_subdom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="4"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="231"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED24493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="330" mass="35441" checksum="14AF9B121A6E0919" modified="2009-03-03" version="1">MDQAHSRALEALQPFIHLTTSSTASSPRFVANIIANATSHPNTYVFAELLETSAVQALGSADTPEEFRGYLKLLEIFAWGTWQEYQETPGLPTLNDQQALKLRLLSLLSLSSTIRPLTYQALMQALSIPTAVKLESLVTTAIYSSLIVARLSPATNPPTVNVTAVAPLRDVRPQTVSTLISILSEWEGRCGDIINGIEAEIAKIKDQTVRNSILKRQCTLALEKAIAADMDGGEDNTGLRSGGRNTKHSLRGGRTAGGIRFGGSSTGGNISNKREYSDDQDDDDDDGYFDNASDGGLDVSGSRMEIDEGAGASRGATRQTKRLLGVGRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXS5</accession>
    <name>B8LXS5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_080150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED24660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002342047.1">
        <property type="nucleotide sequence ID" value="XM_002342006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXS5"/>
    <dbReference type="GeneID" id="8108499"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_080150"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051551_2_0_1"/>
    <dbReference type="InParanoid" id="B8LXS5"/>
    <dbReference type="OrthoDB" id="4526357at2759"/>
    <dbReference type="PhylomeDB" id="B8LXS5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED24660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="181" mass="19299" checksum="3A6E1D2C7242EAC7" modified="2009-03-03" version="1">MARKGPGTDGPLQTALLESTSAATTRASEGQKIFSPIAVFLDKHRSQTTGLAPHLLRALTALSDDLASVAQQHFNAYISGLNQSTYATITQYAPVKSTPTTHPKASIKKPMPLVKQPLPDIRLFVCLPADHAARKMEAYAIYSSLQSQLNLNSAALKEVQATKTGFALCPSSPEALLALEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8LXV8</accession>
    <name>B8LXV8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mis18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_062600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340160.1">
        <property type="nucleotide sequence ID" value="XM_002340119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LXV8"/>
    <dbReference type="GeneID" id="8101118"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_062600"/>
    <dbReference type="eggNOG" id="ENOG502SJVM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035327_0_0_1"/>
    <dbReference type="InParanoid" id="B8LXV8"/>
    <dbReference type="OMA" id="CQQKLGV"/>
    <dbReference type="OrthoDB" id="4187489at2759"/>
    <dbReference type="PhylomeDB" id="B8LXV8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="541"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="181"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="473"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="563"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED22773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="595" mass="65644" checksum="F801E8ACFFAF95DF" modified="2009-03-03" version="1"> </sequence>
</entry>
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            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="754" mass="72101" checksum="5C789C5146EF1270" modified="2009-03-03" version="1"> </sequence>
</entry>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED20878.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="194" mass="20551" checksum="FE3B0BF3BC740B5D" modified="2009-03-03" version="1">MGFSSINSVQQSPQDVDRRCTASSDSGSLPGVQPLTRPNAPGNTMARKGPGTDSPLQTALLESTSTATTRASEGQKIFSPIAVFLDKYRSQTTGLAPHLLRALTALSDDLTSVAQQHFNAYISGISIISILPALSSFPFSSPILNPLPPSPPPSRPPLGLNQSTYATITQYALVKLTPTTHLKASIKKPIPLMK</sequence>
</entry>
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        <location>
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        <location>
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    </feature>
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        <location>
            <begin position="82"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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        <source>
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        <source>
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    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="225" mass="25665" checksum="5EE920E394EF72FE" modified="2009-03-03" version="1">MSAYFQFDLNNLNMANDDFLLYGDEANALSVNKTPTDQMNDLLWNFDYNNFAVDDTDGELFNNNVYNMSIEDNQIQSDSQWQQLLSSPASTSPSLTDGASPRSRSTSQVPDELPAVVTKPRTTKRKRSPVVNKEAHNKVEKRYRSNINAKFAALNDILPVSDAVQSLLDRQFGDEPAQQHRNKGEVLSEAMRYIKQLEERSRLLESEVQILKDNLLPRRRRVAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8M000</accession>
    <name>B8M000_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cell surface metalloreductase (FreA), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_081650</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED20932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002477895.1">
        <property type="nucleotide sequence ID" value="XM_002477850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M000"/>
    <dbReference type="STRING" id="441959.B8M000"/>
    <dbReference type="GeneID" id="8104803"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_081650"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010365_8_1_1"/>
    <dbReference type="InParanoid" id="B8M000"/>
    <dbReference type="OMA" id="KQDTMEL"/>
    <dbReference type="OrthoDB" id="4216461at2759"/>
    <dbReference type="PhylomeDB" id="B8M000"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF26">
        <property type="entry name" value="FAD-BINDING 8 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="10">
        <location>
            <begin position="91"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding 8" evidence="11">
        <location>
            <begin position="259"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric reductase NAD binding" evidence="12">
        <location>
            <begin position="356"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED20932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="500" mass="55714" checksum="AB2DAE28DE05447E" modified="2009-03-03" version="1">MDILVLYAIVVGSLLGLLLVLQALSFISPWTTVFARVVARHFSYPYFLRRHRLVGPWTRASLILHILYASLNTFLTLFRTASVAAAGKRAGTLALINLIFLVSTPHLSFLSDFLGISLRVCHRVHRAIGWTVAALLLFHVSMALFSQRADFSLQQANDLFTLIGAISFAMLFVWCLPLFRSLSYGTFLRFHQGLTGVGLYGIWRHLPTGVGFPMMCLYISLGILAATCLMQIFHMLYHNGLLAGRGFPRAIASGDGDGSSIVRVRLTLPRAIHVQAGQWINLWMPTLSWWSWMQTYPFIVISFSPGKQGILDLLVQSRSATSTALLHRVRTEKLKAVSMRALFSGPHGISQPVAHYETVLAVASGHGIAAVLPYMKKIIHGYNTSTTQARRLHFVWQVETLDVVRGGQDLLNHLLEDDTLDNGYILSISIYVTKDKLTRDRLPFGNHKRAILYQGFPNLRDLISQEASGEMIERLPHIEDEAGKMLVLGKGLKHSQVSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0B1</accession>
    <name>B8M0B1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_084390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478171.1">
        <property type="nucleotide sequence ID" value="XM_002478126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0B1"/>
    <dbReference type="STRING" id="441959.B8M0B1"/>
    <dbReference type="GeneID" id="8101532"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_084390"/>
    <dbReference type="eggNOG" id="ENOG502S0KD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004286_7_1_1"/>
    <dbReference type="InParanoid" id="B8M0B1"/>
    <dbReference type="OMA" id="NKFFEGF"/>
    <dbReference type="OrthoDB" id="4218586at2759"/>
    <dbReference type="PhylomeDB" id="B8M0B1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022198">
        <property type="entry name" value="DUF3723"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12520">
        <property type="entry name" value="DUF3723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="793" mass="91421" checksum="80E227552760DA50" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0F9</accession>
    <name>B8M0F9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HET domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_084870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478219.1">
        <property type="nucleotide sequence ID" value="XM_002478174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0F9"/>
    <dbReference type="GeneID" id="8106093"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_084870"/>
    <dbReference type="eggNOG" id="ENOG502RUBG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_858357_0_0_1"/>
    <dbReference type="InParanoid" id="B8M0F9"/>
    <dbReference type="OrthoDB" id="2426273at2759"/>
    <dbReference type="PhylomeDB" id="B8M0F9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596:SF2">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G17550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED21256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="324" mass="36598" checksum="1F3CA5D68A861767" modified="2009-03-03" version="1">MEPSILNRKYRHMKAMGIDSQSSKGSRRAIKPYARVRAFREMSRAQRIREIYALAHWRTTSRDEDEPYCLATLLLTDQGTLHRITETKDLQERREEFTMGQGLIGTREPPIGWALRRYLYRGEPEGIPANNPLAPVDKAGWHVLLAGITFSATNLPVKLVQGYQLPNFTFTDEDKAITLEVSSFSWLRDQKPPDYWTGILSTFGASKIGIIIEKWPLEYQERQAGFRSYSSTRGAVVAITEATTGKFNCFFCGTVLISRAAEPGQKSSPEILSALLPEFEASLLKDDPSLLRLVSELPSGRCSREGENVVNGQLFDDSQEWCIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8M0Z0</accession>
    <name>B8M0Z0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase II transcriptional coactivator, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_090090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transcriptional coactivator PC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478733.1">
        <property type="nucleotide sequence ID" value="XM_002478688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M0Z0"/>
    <dbReference type="STRING" id="441959.B8M0Z0"/>
    <dbReference type="GeneID" id="8108097"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_090090"/>
    <dbReference type="eggNOG" id="KOG2712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104273_0_1_1"/>
    <dbReference type="InParanoid" id="B8M0Z0"/>
    <dbReference type="OMA" id="NPFWELS"/>
    <dbReference type="OrthoDB" id="2505440at2759"/>
    <dbReference type="PhylomeDB" id="B8M0Z0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.10">
        <property type="entry name" value="Transcriptional Coactivator Pc4, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003173">
        <property type="entry name" value="PC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009044">
        <property type="entry name" value="ssDNA-bd_transcriptional_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045125">
        <property type="entry name" value="Sub1/Tcp4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13215">
        <property type="entry name" value="RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02229">
        <property type="entry name" value="PC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54447">
        <property type="entry name" value="ssDNA-binding transcriptional regulator domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcriptional coactivator p15 (PC4) C-terminal" evidence="8">
        <location>
            <begin position="55"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED21770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="157" mass="17437" checksum="86A905DA6D3D1EEC" modified="2009-03-03" version="1">MSSKSKKRSIEYQSDDGFVVDDDNNNKSRGAKKAKTAESLSSSTNKTDANGDIYWDISSHRRVTISEFRGKSMVNIREYYEKDGQELPGKKGISLPIEQFSALVSHLPEIEQVLSAKGISVPRPSYNGESNEKDEDEGDHSGKKNIDSTSEEDEDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>B8M109</accession>
    <name>B8M109_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nonribosomal peptide synthetase sidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Siderophore peptide synthetase C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_090280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478752.1">
        <property type="nucleotide sequence ID" value="XM_002478707.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M109"/>
    <dbReference type="GeneID" id="8108116"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_090280"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000092_2_0_1"/>
    <dbReference type="InParanoid" id="B8M109"/>
    <dbReference type="OMA" id="CTMLPRM"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="PhylomeDB" id="B8M109"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031169">
        <property type="term" value="P:ferrichrome biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.980:FF:000001">
        <property type="entry name" value="Non-ribosomal peptide synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000033">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000024">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003417">
        <property type="entry name" value="PRK04813.1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1765"/>
            <end position="1842"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2335"/>
            <end position="2408"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="3412"/>
            <end position="3489"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="3974"/>
            <end position="4047"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="4523"/>
            <end position="4596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00078302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED21789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="5091" mass="566090" checksum="DE0D9FBFD9BD216E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1G5</accession>
    <name>B8M1G5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amine oxidase</fullName>
            <ecNumber evidence="6">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_091010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="6"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478824.1">
        <property type="nucleotide sequence ID" value="XM_002478779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1G5"/>
    <dbReference type="STRING" id="441959.B8M1G5"/>
    <dbReference type="GeneID" id="8101591"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_091010"/>
    <dbReference type="eggNOG" id="KOG0029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004498_0_3_1"/>
    <dbReference type="InParanoid" id="B8M1G5"/>
    <dbReference type="OMA" id="GETAYEW"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="PhylomeDB" id="B8M1G5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF14">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="7">
        <location>
            <begin position="174"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="194"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="506"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="593"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED21861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="633" mass="69343" checksum="47D41DCB56B35792" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1W1</accession>
    <name>B8M1W1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">mitochondrial processing peptidase</fullName>
            <ecNumber evidence="5">3.4.24.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Beta-MPP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSTA_085700</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. Preferentially, cleaves after an arginine at position P2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.</text>
            <dbReference type="EC" id="3.4.24.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.64" evidence="5"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478302.1">
        <property type="nucleotide sequence ID" value="XM_002478257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1W1"/>
    <dbReference type="FunCoup" id="B8M1W1">
        <property type="interactions" value="914"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M1W1"/>
    <dbReference type="MEROPS" id="M16.980"/>
    <dbReference type="GeneID" id="8104535"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_085700"/>
    <dbReference type="eggNOG" id="KOG0960">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2774">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018938_0_0_1"/>
    <dbReference type="InParanoid" id="B8M1W1"/>
    <dbReference type="OMA" id="EMFTETH"/>
    <dbReference type="OrthoDB" id="10251424at2759"/>
    <dbReference type="PhylomeDB" id="B8M1W1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05238">
        <property type="entry name" value="Gne_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000002">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000001">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050005">
        <property type="entry name" value="DenD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF043036">
        <property type="entry name" value="ErythonDh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF149">
        <property type="entry name" value="GH01077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="17">
        <location>
            <begin position="4"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="16">
        <location>
            <begin position="377"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="18">
        <location>
            <begin position="529"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EED21339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="805" mass="87912" checksum="AF8789CDEF093F98" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8M1Y5</accession>
    <name>B8M1Y5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="4 14">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSTA_085940</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="4 14"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478326.1">
        <property type="nucleotide sequence ID" value="XM_002478281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M1Y5"/>
    <dbReference type="FunCoup" id="B8M1Y5">
        <property type="interactions" value="856"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M1Y5"/>
    <dbReference type="GeneID" id="8104559"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_085940"/>
    <dbReference type="eggNOG" id="KOG0786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_3_1"/>
    <dbReference type="InParanoid" id="B8M1Y5"/>
    <dbReference type="OMA" id="EYDLGAR"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="PhylomeDB" id="B8M1Y5"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF1">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="5"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EED21363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="365" mass="39028" checksum="30799E13FBE4CDFC" modified="2009-03-03" version="1">MAPYNIVVFAGDYCGPEVTAEAVKVLRVIEKHRSDIEFNFQEHPLGGASIDAHGEPLTDAALTAAKNADAVILGAIGGPKWGHGTVRPEQGILKLRKEMGTFGNLRPCSFAAPSLVDISPLKADVCRGVDFNIIRELTGGIYFGDRKEDTGDGYALDTEPYSRPEIERITRLAAHLALQHDPPLPIWSLDKANVLATSRLWRKVVTEVITNEFPQLKLGHHLIDSAAMLMVKDPRKLNGIVVTSNLFGDIISDEASVIPGSLGLLPSASLTGVPDGKTKVNGIYEPIHGSAPDIAGKGIVNPVAAILSMAMLLQYSLQRPAEARLIEEAVRNVTEAGIRTGDIGGKSTTVEVGDAVAAELEKLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8M253</accession>
    <name>B8M253_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_087530</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478480.1">
        <property type="nucleotide sequence ID" value="XM_002478435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M253"/>
    <dbReference type="GeneID" id="8100882"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_087530"/>
    <dbReference type="eggNOG" id="ENOG502S42W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053359_0_1_1"/>
    <dbReference type="InParanoid" id="B8M253"/>
    <dbReference type="OMA" id="HRYFAIQ"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="PhylomeDB" id="B8M253"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF2">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="8">
        <location>
            <begin position="89"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED21517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="261" mass="28002" checksum="E0F21AA1FD73E457" modified="2009-03-03" version="1">MAAVNGVDRNDFQPTGQLFRDHGITASTQQGAQQITRKPNDSTNQTPNSNNNNPNQADEGDAAAEHSWYRRIAEKYGTLELDNKGSVARDHLALERTFLAWLRTSLSFASIGIAVTQLFRLNSSVPCTNPGPTSQTSLSDNANNVLQNSIRSSPSLLEVLLAPPPSYSSSSPDTIDVIANTATTSGQYGNIGKPLGATFIGIAILILIIGFHRYFESQYWIVRGKFPASRGSVALVAFVAAGLVIASFVVILVIAPTAREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8M265</accession>
    <name>B8M265_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_087650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478492.1">
        <property type="nucleotide sequence ID" value="XM_002478447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M265"/>
    <dbReference type="GeneID" id="8100894"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_087650"/>
    <dbReference type="eggNOG" id="ENOG502SP6Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053392_0_0_1"/>
    <dbReference type="InParanoid" id="B8M265"/>
    <dbReference type="OMA" id="REVINWN"/>
    <dbReference type="OrthoDB" id="203796at2759"/>
    <dbReference type="PhylomeDB" id="B8M265"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848:SF1">
        <property type="entry name" value="SUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED21529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="352" mass="39467" checksum="2D2999FB4BE70B0A" modified="2009-03-03" version="1">MTKKGIQEQHTDQSDIQDQSHQNAENHDNNIFDQTFTSEPPPYSSSIPNTAIPRQPLRTPTTSTTTTTSPTPSSTSATFPLIDFSKYSIPDSSLSKDGSTISTYHPSFSTNPANLVKFIQEQAALPPLPYIHILGDDPTGLQRDFDIKINMLPMFMNQSFAGGGKQNQWNYVRLVADGELAYRGRSDAAISPAVKGGLDEWAKKFCKESSAVKSFTLTRQLSNWNTSYIEGQIRSLIASTGYNKPVTITFPVKYSKIVVYPPKSSSFNSFFTTLMSPLLDKKRYEVVRAVWPYASLPPGPETTNRVPVVQSEEMWWEEWRDVLRWAIVSKKCSGWVSVDDMLEFRMAPGNHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8M2K5</accession>
    <name>B8M2K5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arylsulfatase, putative</fullName>
            <ecNumber evidence="6">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_091570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="6"/>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED21916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478879.1">
        <property type="nucleotide sequence ID" value="XM_002478834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M2K5"/>
    <dbReference type="STRING" id="441959.B8M2K5"/>
    <dbReference type="GeneID" id="8098543"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_091570"/>
    <dbReference type="eggNOG" id="KOG3867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_11_1_1"/>
    <dbReference type="InParanoid" id="B8M2K5"/>
    <dbReference type="OMA" id="YSDQWAQ"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="PhylomeDB" id="B8M2K5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16025">
        <property type="entry name" value="PAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF33">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="5">
        <location>
            <begin position="7"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED21916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="567" mass="63167" checksum="71596CC63261D0A3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8M333</accession>
    <name>B8M333_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Solid-state culture expressed protein (Aos23), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_092540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962653">
        <property type="protein sequence ID" value="EED22009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002478972.1">
        <property type="nucleotide sequence ID" value="XM_002478927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M333"/>
    <dbReference type="STRING" id="441959.B8M333"/>
    <dbReference type="GeneID" id="8109507"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_092540"/>
    <dbReference type="eggNOG" id="ENOG502RNWB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_960356_0_0_1"/>
    <dbReference type="InParanoid" id="B8M333"/>
    <dbReference type="OMA" id="NEDPTAH"/>
    <dbReference type="OrthoDB" id="5388207at2759"/>
    <dbReference type="PhylomeDB" id="B8M333"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED22009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="290" mass="30386" checksum="61CB2B87673723C7" modified="2009-03-03" version="1">METVNKVVDAGYKAIWGEQNTNEQTTASNSQPTTSTGVTGIQSVDKVVEAGKKAIWGESTTDSQQQTSTSHGEEPVAGKRGLGTATDPYDAGNRDEQYDAPPVEAGGLPTSIPTSEQRNIETTDTSLNTPNMGSSSGTAVAGTEAAKDLKPSATGLRPDPAQPGNAADFTSRAVPDGGPGQTLKHTSKPFEEESQKLAKDLQNINVNDDKPKVHTVTGGVAVSRPNQAVHPKEDKEDSHSSSSDFSSGVVDNRGQDKTQGQGQSPKSKTSKLEKVKSKLHLGNHSPKASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8M3W7</accession>
    <name>B8M3W7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C2H2 finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_039140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481144.1">
        <property type="nucleotide sequence ID" value="XM_002481099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M3W7"/>
    <dbReference type="FunCoup" id="B8M3W7">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M3W7"/>
    <dbReference type="GeneID" id="8109252"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_039140"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006466_0_0_1"/>
    <dbReference type="InParanoid" id="B8M3W7"/>
    <dbReference type="OMA" id="ANFIIWH"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="PhylomeDB" id="B8M3W7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="89"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED20710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="946" mass="105555" checksum="ED3B81689EC1BE75" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5A2</accession>
    <name>B8M5A2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_029800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480142.1">
        <property type="nucleotide sequence ID" value="XM_002480097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5A2"/>
    <dbReference type="GeneID" id="8106547"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_029800"/>
    <dbReference type="eggNOG" id="ENOG502SU96">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116849_1_1_1"/>
    <dbReference type="InParanoid" id="B8M5A2"/>
    <dbReference type="OMA" id="TIVPWAF"/>
    <dbReference type="OrthoDB" id="5309803at2759"/>
    <dbReference type="PhylomeDB" id="B8M5A2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="115" mass="13072" checksum="AF6404856D8AE264" modified="2009-03-03" version="1" fragment="single">MAWYSLLPESMNTLETWLIRFFILLGILTIGPWAGLVIFDIVFYIARVIAYEFPLIGGRANGERKPRAPTLTERPSGRRRAFSLRGEAVGGEGSQSTTLEKEMMRRLVHTEKDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5A5</accession>
    <name>B8M5A5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dihydrodipicolinate synthetase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_029830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480145.1">
        <property type="nucleotide sequence ID" value="XM_002480100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5A5"/>
    <dbReference type="STRING" id="441959.B8M5A5"/>
    <dbReference type="GeneID" id="8106550"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_029830"/>
    <dbReference type="eggNOG" id="ENOG502SG3E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_0_2_1"/>
    <dbReference type="InParanoid" id="B8M5A5"/>
    <dbReference type="OMA" id="KHAVACY"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="PhylomeDB" id="B8M5A5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF47">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED19711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="323" mass="34289" checksum="C948A3481F2F1392" modified="2009-03-03" version="1">MASNLGVPPAGVWAPAVTAFNSEDDTIDYESAKKYYTYLSRSGLVGLVILGTNAETFLLTREERAQLIKTAREAVGPDYPIMAGVGGHSTKQVLEYSQDAYDAGANYLLVLPPAYFGKQTTPAVVKRFFADVARKAPLPVVLYNFPGVTNGVDLDSELITDIVNASAAASPDGISNVVGVKLTCAQVGKITRLAGTFGPDVFSVYGGQSDFLLGGLSVGSAGCIAAFANIFPKTISHIYNLYKEGKHEEALALHQKAALAESPSKSGIATTKYAVALYSAPKAGIENAEEKFLPRTPYEPPSEATKQLVRNVMSELAAIEEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5I7</accession>
    <name>B8M5I7_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_031400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480315.1">
        <property type="nucleotide sequence ID" value="XM_002480270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5I7"/>
    <dbReference type="GeneID" id="8107751"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_031400"/>
    <dbReference type="eggNOG" id="ENOG502SXT0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116801_2_0_1"/>
    <dbReference type="InParanoid" id="B8M5I7"/>
    <dbReference type="OMA" id="AEPRHKR"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED19881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="140" mass="15569" checksum="77FAC2DCDA9C1CD4" modified="2009-03-03" version="1">MSTRKRKQDAEEEEDFQALPSDESEEEEEYQSSDAEGDDYDDSEEEEEEEEEEEEEGEGGEGGEGEKEEETTKEEAPAPKKRKTAHDSKAEEDGEGEEKEEEEDANDTADKSGPAQAAKKAKGGQVPKEDDLSEETEGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8M5X5</accession>
    <name>B8M5X5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PXA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_033450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480536.1">
        <property type="nucleotide sequence ID" value="XM_002480491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M5X5"/>
    <dbReference type="STRING" id="441959.B8M5X5"/>
    <dbReference type="GeneID" id="8105083"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_033450"/>
    <dbReference type="eggNOG" id="ENOG502QQBH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018250_0_0_1"/>
    <dbReference type="InParanoid" id="B8M5X5"/>
    <dbReference type="OMA" id="KEFVYSW"/>
    <dbReference type="OrthoDB" id="5582218at2759"/>
    <dbReference type="PhylomeDB" id="B8M5X5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051837">
        <property type="entry name" value="SortingNexin/PXDomain-PKLike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999">
        <property type="entry name" value="PX SERINE/THREONINE KINASE PXK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999:SF23">
        <property type="entry name" value="SORTING NEXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PXA" evidence="4">
        <location>
            <begin position="94"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED20102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="439" mass="48453" checksum="CDDA50A36CAB28F5" modified="2009-03-03" version="1">MTTSLPRRGPSPFNTAATTSQSRPSNGPYTSQQPGRTKSRTEHRRNTPDAELTDTSGDKNTVTLIRRVLCPDASAYGSSAPRPLQDLLPPLTSSNDVDLQLYALIAVIIKEFVYSWYARITPDHVFVDEVLQLIAHCTRALEQRLRRVDVAQLVLDEVTGLIQAHLTAYRIAAQGSDLISLKSSTPEIYHNLHAHPALSPVPDVSAASRISEQQENENVYRHLLAQGVLAVLLPTEDLENVCLRTLVEDVLSDLILGNQVNGRVCEGWFIWTAISKVITVVKQRNSDSTMTVGQRLDVVADANRLERFGLLSDDGDRDENARESKQSTVSQWLWKILYSVYLAYFTMRFIIGGLLHTALSNPEAATAEILQADPVTTIKTANQPSLCRPVLRYRAFSFISQLMGVPQKMPWLTGSASLVQSLILAGPGKLGETGSVLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6P1</accession>
    <name>B8M6P1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosome biogenesis protein Ssf2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_027940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED19503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002479937.1">
        <property type="nucleotide sequence ID" value="XM_002479892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6P1"/>
    <dbReference type="FunCoup" id="B8M6P1">
        <property type="interactions" value="863"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M6P1"/>
    <dbReference type="GeneID" id="8108310"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_027940"/>
    <dbReference type="eggNOG" id="KOG2963">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026936_2_0_1"/>
    <dbReference type="InParanoid" id="B8M6P1"/>
    <dbReference type="OMA" id="KDYTVMT"/>
    <dbReference type="OrthoDB" id="10261452at2759"/>
    <dbReference type="PhylomeDB" id="B8M6P1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045112">
        <property type="entry name" value="PPAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661">
        <property type="entry name" value="PETER PAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661:SF5">
        <property type="entry name" value="SUPPRESSOR OF SWI4 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="31"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED19503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="446" mass="50327" checksum="D30AD19309AE6217" modified="2009-03-03" version="1">MARRRTKKRTQLHGQNDSANSKNAASQSPKSMVIRIGASEVGSSVSQLAKDFRLMMEPDTASRLKERRANKLKDYVVMAGPLGVTHLILFSKSSTGNTNMRLALTPRGPTLHFKVENYSLCKDVAKALKHPRGGGQDHRTPPLLVMNNFNTPDADEDSKIPKRLESLATTVFQSLFPPINPQATPLTSIRRVMMLNREKVPNDDAYILKLRHYAITTRKTGVSKRIRRLDPTLQRHKDPKKSLPNLGKLEDVADYLLDPAAGGYTSASETELDTDAEVEITESTTKKVLSRREMQRLKAGEKSATNKQSVKPNVEKRAVKLVELGPRMTLRLKKVEEGLCGGRIMWHDFISKSEKEVKKMDDEWNRRRKEKEERKKQQRANIEKKKQDKAKAKANGQGGDNADDDDEDVSMDDDYEWDSDEYDGEAGVEEDSEGDNGSDDDEFMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8M6R3</accession>
    <name>B8M6R3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_033750</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480567.1">
        <property type="nucleotide sequence ID" value="XM_002480522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M6R3"/>
    <dbReference type="STRING" id="441959.B8M6R3"/>
    <dbReference type="GeneID" id="8097792"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_033750"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018624_0_0_1"/>
    <dbReference type="InParanoid" id="B8M6R3"/>
    <dbReference type="OMA" id="KDFNAMY"/>
    <dbReference type="OrthoDB" id="426001at2759"/>
    <dbReference type="PhylomeDB" id="B8M6R3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14521">
        <property type="entry name" value="DSP_fungal_SDP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="735"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="316"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="8">
        <location>
            <begin position="431"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="586"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="62"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="608"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED20133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="769" mass="85117" checksum="0A1CF79561C34C2A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8M7C0</accession>
    <name>B8M7C0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_035660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962654">
        <property type="protein sequence ID" value="EED20340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002480774.1">
        <property type="nucleotide sequence ID" value="XM_002480729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M7C0"/>
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        <source>
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            <dbReference type="PROSITE" id="PS51253"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
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    </evidence>
    <sequence length="331" mass="38026" checksum="EE2EDE2B9BF57F7C" modified="2009-03-03" version="1">MPRGWNLDPVARKAPKRLASRYYQLKTGHAPIGTYLHRIGRRESPECQACKEPHETVRHVLFECRGRRTGRRALYRALEKAGVPLPTAAEESPEARLFAEPRATQGLLQFMAEANLFNDNERTAREAEISDLWGWDTLEEDEQEGQILLAISDLQNGRIQRVAQAARIYEIPRTTLQDRLNGIQQRSLVRANSHKLTQYEEESLVKWVLDLDRRGLPPQHSLVREMANYILSQHGKPQVGKNWITKLIKRRPEIDSKFARKYNYERAKCEDPKIIQEHFDRVQAAISEYGILPEDIFNFDETGFAMGLCATAKVITGSDRYAQPKLLQPGN</sequence>
</entry>
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    <accession>B8M7C3</accession>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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            <dbReference type="PubMed" id="25676766"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
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        <location>
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            <end position="1452"/>
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            <begin position="24"/>
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            <end position="249"/>
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            <begin position="635"/>
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        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
    <sequence length="1998" mass="221065" checksum="B1DB9DF80CE35BD1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8N9</accession>
    <name>B8M8N9_TALSN</name>
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        <submittedName>
            <fullName evidence="4">Reverse transcriptase, putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">TSTA_037700</name>
    </gene>
    <organism evidence="4 5">
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
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                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002480941.1"/>
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    <dbReference type="STRING" id="441959.B8M8N9"/>
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    <dbReference type="VEuPathDB" id="FungiDB:TSTA_037700"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_26_3_1"/>
    <dbReference type="InParanoid" id="B8M8N9"/>
    <dbReference type="OMA" id="HECREAT"/>
    <dbReference type="OrthoDB" id="4357294at2759"/>
    <dbReference type="PhylomeDB" id="B8M8N9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
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    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
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        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
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        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <location>
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        </location>
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        </location>
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        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED20552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="747" mass="82124" checksum="F6C51B4F336FA043" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8M8W2</accession>
    <name>B8M8W2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Origin recognition complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_038320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC4 family.</text>
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        <property type="protein sequence ID" value="EED20625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_002481014.1"/>
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    <dbReference type="AlphaFoldDB" id="B8M8W2"/>
    <dbReference type="FunCoup" id="B8M8W2">
        <property type="interactions" value="716"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8M8W2"/>
    <dbReference type="GeneID" id="8107874"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_038320"/>
    <dbReference type="eggNOG" id="KOG2228">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007115_3_0_1"/>
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    <dbReference type="OMA" id="MWRQLGR"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005664">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001597">
        <property type="entry name" value="Origin recognition complex subunit Orc4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016527">
        <property type="entry name" value="ORC4"/>
    </dbReference>
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        <property type="entry name" value="ORC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14629">
        <property type="entry name" value="ORC4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="277"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED20625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="702" mass="77143" checksum="835810616B43F64E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B8M980</accession>
    <name>B8M980_TALSN</name>
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        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="16" type="ORF">TSTA_112110</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481367.1">
        <property type="nucleotide sequence ID" value="XM_002481322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8M980"/>
    <dbReference type="STRING" id="441959.B8M980"/>
    <dbReference type="GeneID" id="8098866"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_112110"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="B8M980"/>
    <dbReference type="OMA" id="PWLDQPV"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="PhylomeDB" id="B8M980"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF23">
        <property type="entry name" value="FERRIC-CHELATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="298"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="495"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EED17375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="610" mass="68980" checksum="883A66ADBBA3EC97" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8M982</accession>
    <name>B8M982_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_112120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
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        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="protein sequence ID" value="EED17377.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
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        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF13">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="612"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="684"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="779"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="896"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="922"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="241"/>
            <end position="523"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="532"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EED17377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1019" mass="111958" checksum="02547B79AF8C180A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9V2</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">TSTA_118700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="8099794"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_118700"/>
    <dbReference type="HOGENOM" id="CLU_957054_0_0_1"/>
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    <dbReference type="OrthoDB" id="4227524at2759"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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        <location>
            <begin position="22"/>
            <end position="291"/>
        </location>
    </feature>
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        <location>
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            <end position="71"/>
        </location>
    </feature>
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        <location>
            <begin position="104"/>
            <end position="264"/>
        </location>
    </feature>
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            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
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        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="124"/>
        </location>
    </feature>
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            <end position="150"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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        </location>
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    </feature>
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            <begin position="238"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED18104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="291" mass="29499" checksum="A21C226513FA51EB" modified="2009-03-03" version="1">MKYTTALTVLLAFGPATTILAAPVSQDPTSALTGAPSGQNEGAKQPAAGPAPGSSSQGLSGSSSGNEGLLDKVEKIVKDVLGGLRKRGLVEEVGEVVQMTVDSTSKLLNGESSGSQSSYNTQSTDPDALSQGAPQGGKGDDDKDGDDKKAHPAPAPTPAPAPAPSKDSSSSSPLSKLIGGRSNAPLSDQTDPVNTSGTTAPISNEGTQPTESHKVPTEQSSPIEGVTKPSTPIPVPVDTKKQEGEKKEKEGPNIGTPTSDAFQLSPEEIEVLKKVLQSQSKDGQGEGLSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8M9Y4</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
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            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
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    </dbReference>
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    <dbReference type="STRING" id="441959.B8M9Y4"/>
    <dbReference type="GeneID" id="8108574"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054818_0_0_1"/>
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    <dbReference type="OrthoDB" id="193478at2759"/>
    <dbReference type="PhylomeDB" id="B8M9Y4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018750">
        <property type="entry name" value="DUF2306_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10067">
        <property type="entry name" value="DUF2306"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
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        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
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        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="348" mass="38898" checksum="9B716EE9E54F7C5E" modified="2009-03-03" version="1">MPIDETTRLLRRSSELGTPQVENGYIHNKASSNLKGIFGVLRPGFTKKYNFWLFSIFGFFMAFFCFARLKYLSTSVLEAELTPGDWFWFHDGILHIGFMLHLATMLPAGLLMILQFVPRIRYKFMLFHRLNGYVVIILALIGNVTAMIIARRAFGGDMGSQTCTGFLALASTVAMALAWWNIRCLQIDLHRAWMLRAMFWMGSIVSTRAIMPLMSIVQTALGGYFIAWPCDEIIFILGNREDLVMSQFPQCLIPNGTTSGWVAVEGDLDFSNPVGLGAIFNTNFGAGLWLALILHMIGVEIYLALTPIESERLRKVSYERQLAAGYENPGNCGTTVSKWGDIGSNATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAS6</accession>
    <name>B8MAS6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Ribokinase</fullName>
            <shortName evidence="12">RK</shortName>
            <ecNumber evidence="2 12">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSTA_115610</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="2 12"/>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481758.1">
        <property type="nucleotide sequence ID" value="XM_002481713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAS6"/>
    <dbReference type="FunCoup" id="B8MAS6">
        <property type="interactions" value="1091"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MAS6"/>
    <dbReference type="GeneID" id="8099588"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_115610"/>
    <dbReference type="eggNOG" id="KOG2855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_2_0_1"/>
    <dbReference type="InParanoid" id="B8MAS6"/>
    <dbReference type="OMA" id="DIVLIQQ"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="PhylomeDB" id="B8MAS6"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000045">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="14">
        <location>
            <begin position="5"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="40"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="266"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="310"/>
            <end position="311"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EED17766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="381" mass="40786" checksum="5D1B4377017BEC9B" modified="2009-03-03" version="1">MAPLLRVIGSLNADMVSVTPRFPEAGETITATSFTTSAGGKGANQAVACGRLSRSRPTETQSSTSNNPVNVEMVGAVGSRDGHFQSLLGPTLEKSGLDTSRIRTVDDYTGVAVIIVDSSAGGENRILFSPGANYSGMQAIPDVLNMGLAPPVPDIIIMQGEIPTETTIGILREIAKYKKSQRDNGRKGIDAGPEVMLNPAPAPPGGLPEDVYGAIDHLIMNETEAELMAPKTEELLRVVPNAKGASLREQAAQYFHKLGVTYVVITLGAKGVWYSSCDAGTAIAADNHTRFTNEISAAKVSRVLDTTAAGDTFIGGYATHIARWREQRRARGKSSHELEQNEKTERYQVVMDEAMKRAGRASARCVEKQGAMNSIPWEDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MAZ9</accession>
    <name>B8MAZ9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_124270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482692.1">
        <property type="nucleotide sequence ID" value="XM_002482647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MAZ9"/>
    <dbReference type="STRING" id="441959.B8MAZ9"/>
    <dbReference type="GeneID" id="8098378"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_124270"/>
    <dbReference type="eggNOG" id="ENOG502SDCM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058482_0_0_1"/>
    <dbReference type="InParanoid" id="B8MAZ9"/>
    <dbReference type="OMA" id="HIQWADT"/>
    <dbReference type="OrthoDB" id="5431245at2759"/>
    <dbReference type="PhylomeDB" id="B8MAZ9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037738">
        <property type="entry name" value="Ecm13-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36826">
        <property type="entry name" value="PROTEIN ECM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36826:SF1">
        <property type="entry name" value="PROTEIN ECM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="263" mass="29538" checksum="B3EBBC9A1ED217FB" modified="2009-03-03" version="1">MAPSLLSNTSFLPRRPDQPKKKMSITQTYYLAHTARSKLSKEAARSDHDLRLLVGHANLLDSLMLDLANAEREQEQWFNNTVRNATKKAQPSHIRWADTIEEESMEDDVSDDDSDMSDDDYSDYDEEEEDDEEKFEDLTAIYTAAAVAKPLRRAASPPALISMNEVASDEEEEEEEAARLTLTRSPSRTQSPPGLTEDLSSDDEEDSMPPSPEQLTMDAFASTSGKKQPATQTNLLSETESQSLHNDSCLLILKTKVLLLYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8MBP7</accession>
    <name>B8MBP7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_119420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED18180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482172.1">
        <property type="nucleotide sequence ID" value="XM_002482127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MBP7"/>
    <dbReference type="STRING" id="441959.B8MBP7"/>
    <dbReference type="GeneID" id="8105217"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_119420"/>
    <dbReference type="eggNOG" id="ENOG502SXAR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070864_0_0_1"/>
    <dbReference type="InParanoid" id="B8MBP7"/>
    <dbReference type="OMA" id="CEYARTD"/>
    <dbReference type="OrthoDB" id="4159781at2759"/>
    <dbReference type="PhylomeDB" id="B8MBP7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED18180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="35929" checksum="0E967C0836075651" modified="2009-03-03" version="1">MIAYNNHVRNAEPEKSRNCDRKNPCTACLLRGSEDECEYARTDEDRYHISQAKEIENLRKELNRLKRKLEDGEQKSQSQSQAKSQSYGSTAEDYGYGGVLVVDERPNKRRFGEEGNVTNLWNLGAPYATSASAATGMAYSTQPEMAQHNAYIPMEHHPQHQQYYQQNTAAIDTVVSTNPLQYGMHQLQQHRQPDFWRGKQEQLETIYKIVCDCDEYWVPSIIDIVRNSLSPEDAIVSIRSLLRSGSSRYSYSNSNSNNSNDGGTVMAASTITTTSDSQSPDSASSMIPVNMDSVSYVHVDCVLGVDGNLPPTDQYRSSGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDG1</accession>
    <name>B8MDG1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Stress response RCI peptide, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_117100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481916.1">
        <property type="nucleotide sequence ID" value="XM_002481871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MDG1"/>
    <dbReference type="FunCoup" id="B8MDG1">
        <property type="interactions" value="1217"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MDG1"/>
    <dbReference type="GeneID" id="8104939"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_117100"/>
    <dbReference type="eggNOG" id="KOG1773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107649_1_0_1"/>
    <dbReference type="InParanoid" id="B8MDG1"/>
    <dbReference type="OMA" id="EYVYYER"/>
    <dbReference type="OrthoDB" id="2152119at2759"/>
    <dbReference type="PhylomeDB" id="B8MDG1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF42">
        <property type="entry name" value="UPF0057 MEMBRANE PROTEIN ZK632.10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01309">
        <property type="entry name" value="UPF0057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED17924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="97" mass="10571" checksum="DE215E39D2BE3514" modified="2009-03-03" version="1">MADCSALCIIIITLFIPPLGVFLISGCSADLLINILLTILGYFPGHIHAYYLEYVYYHRRGLAAGGATLAKPATGVYSERIQSGGHHQQTQYGTIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>B8MDJ8</accession>
    <name>B8MDJ8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_117430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962655">
        <property type="protein sequence ID" value="EED17961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002481953.1">
        <property type="nucleotide sequence ID" value="XM_002481908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MDJ8"/>
    <dbReference type="STRING" id="441959.B8MDJ8"/>
    <dbReference type="GeneID" id="8105801"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_117430"/>
    <dbReference type="eggNOG" id="ENOG502SEIT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044882_0_0_1"/>
    <dbReference type="InParanoid" id="B8MDJ8"/>
    <dbReference type="OMA" id="DRFWFDD"/>
    <dbReference type="OrthoDB" id="4586300at2759"/>
    <dbReference type="PhylomeDB" id="B8MDJ8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED17961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="439" mass="51163" checksum="0BE660006B235FD2" modified="2009-03-03" version="1">MANSNDDRSTDTTTNTQNKTTPPPDNKADSENPFIAFRRYADEQISSMLQAVMGLPSSAVPPFSDKWLYFQNTDNNDRGADRESDYRSDDHRPCRRWGFHRDDNFFDRWHSHHRFSDRGFNSFFDGFPMNLGSFLFPESMLEGDSQTPYSPLYLERSQGHDSRYGRTSSSLFSSRKPADLDPNEPRWRDAFEDLLRVTNGQEMLDRDTEPERSKQSAEKWIKGLIQRGSLGNNWRLLGSQDSQSGLTLERFQQHDRDRRGQEPPRQQEDFLEDKIETKDIETELDLYDRFLDDILNAHERYSRAFADSPLMRLLDEERRRHTQRDNYSQSSEDTNISSKDWLEYTFDGNKNLLASQMTTDNNTSEESRVISTMTRSVRRTLPDGSILTKTIKTKRFADGREESDESTEVIPPPTSEKNSEAVRDVDNDKDSQGGWFWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8ME03</accession>
    <name>B8ME03_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_011890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483314.1">
        <property type="nucleotide sequence ID" value="XM_002483269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8ME03"/>
    <dbReference type="STRING" id="441959.B8ME03"/>
    <dbReference type="GeneID" id="8104037"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_011890"/>
    <dbReference type="eggNOG" id="ENOG502SSB8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046870_4_0_1"/>
    <dbReference type="InParanoid" id="B8ME03"/>
    <dbReference type="OMA" id="WIVIWEM"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="PhylomeDB" id="B8ME03"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF146">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="27"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED16080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="266" mass="30319" checksum="141BB2F47FD97D43" modified="2009-03-03" version="1">MYEISSRQVDACAYTMIVLTGIAVISRFFLRGLRKEPFRPEDVFILFAYVTFNILATITLVVVPVAYQIMDVSADVKPIYNDLFDDEVFQLKILFASNILFPMVLWSVKFSLLALSKRVMYQQFEWIRAWMVVVGLVILTYVGNWISTLYSCTPIQDYFRPGGCTSPRDVRAQVANLYYLVASEILTDVLIMALPIMFLHQSWVGLPTGTYRRTAAIFSVGIICIVTSLARGITIGTRMKVDTPTFPWIVIWEMIEGGIGTMHLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEE5</accession>
    <name>B8MEE5_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_016500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483806.1">
        <property type="nucleotide sequence ID" value="XM_002483761.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483807.1">
        <property type="nucleotide sequence ID" value="XM_002483762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEE5"/>
    <dbReference type="FunCoup" id="B8MEE5">
        <property type="interactions" value="577"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MEE5"/>
    <dbReference type="GeneID" id="8106423"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_016500"/>
    <dbReference type="eggNOG" id="KOG1635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_10_2_1"/>
    <dbReference type="InParanoid" id="B8MEE5"/>
    <dbReference type="OMA" id="LFWESHD"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1060.10:FF:000006">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774:SF1">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="7">
        <location>
            <begin position="36"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED16572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="204" mass="23008" checksum="6097151C4E640597" modified="2009-03-03" version="1">MTSFLSRLFRPLSTTSTPAYSVTPRNAIIMPDKAQKATLAAGCFWGVEHLYRKHFGNGKGLIDAKVGYAGGHADSPTYRAVCTGNTGHAEALQVIFDPSIVTYRQLIEFFYRMHDPTTENRQGPDVGTQYRSAIFTHDEEQAKIAKDITDKVAKQWYKQPLSTQIVPAGQWWDAEEYHQLYLHNNPSGYECPSHFLRNLPPLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEG8</accession>
    <name>B8MEG8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome c oxidase subunit 4, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome c oxidase polypeptide IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_016720</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 5B family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483829.1">
        <property type="nucleotide sequence ID" value="XM_002483784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MEG8"/>
    <dbReference type="FunCoup" id="B8MEG8">
        <property type="interactions" value="444"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MEG8"/>
    <dbReference type="GeneID" id="8103645"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_016720"/>
    <dbReference type="eggNOG" id="KOG3352">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091071_0_0_1"/>
    <dbReference type="InParanoid" id="B8MEG8"/>
    <dbReference type="OMA" id="DHKPYWM"/>
    <dbReference type="OrthoDB" id="10249250at2759"/>
    <dbReference type="PhylomeDB" id="B8MEG8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990145">
        <property type="term" value="P:maintenance of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00924">
        <property type="entry name" value="Cyt_c_Oxidase_Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.11.10:FF:000003">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.11.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002124">
        <property type="entry name" value="Cyt_c_oxidase_su5b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036972">
        <property type="entry name" value="Cyt_c_oxidase_su5b_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01215">
        <property type="entry name" value="COX5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57802">
        <property type="entry name" value="Rubredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51359">
        <property type="entry name" value="COX5B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602124-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED16595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="193" mass="21443" checksum="41503F7602C2E582" modified="2009-03-03" version="1">MFASRAVSALTKRAPVRAFTKARPFTSSVTRFSDNKLNVPGKIIPYEEVKTEDDLLPPGTKAGQVPSDLEQATGLERLELLGKMQGIDVFDMKPLDASRKGTLENPIIVNGAGDEQYAGCTGYPADSHIVNWLTVSRERPIERCLECGNVVKLNYVGPDTDAHGHDDHAHGHHATYEEPKTFADYVKPEYWYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8MEZ3</accession>
    <name>B8MEZ3_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSTA_007090</name>
        <name evidence="11" type="ORF">TSTA_008870</name>
        <name evidence="10" type="ORF">TSTA_107620</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="EMBL" id="EQ962667">
        <property type="protein sequence ID" value="EED11413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED15762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002482996.1">
        <property type="nucleotide sequence ID" value="XM_002482951.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486793.1">
        <property type="nucleotide sequence ID" value="XM_002486748.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488856.1">
        <property type="nucleotide sequence ID" value="XM_002488811.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MEZ3"/>
    <dbReference type="GeneID" id="8100752"/>
    <dbReference type="GeneID" id="8106791"/>
    <dbReference type="GeneID" id="8108989"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_007090"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_008870"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_107620"/>
    <dbReference type="eggNOG" id="KOG0351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004144_0_0_1"/>
    <dbReference type="InParanoid" id="B8MEZ3"/>
    <dbReference type="OrthoDB" id="5153301at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022698">
        <property type="entry name" value="OrsD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF154">
        <property type="entry name" value="RECQ HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12013">
        <property type="entry name" value="OrsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0347">Helicase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="943"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="1135"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1308"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1311"/>
            <end position="1327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EED11413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED14555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED15762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1513" mass="173853" checksum="6D2C8203F6E18A78" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MF27</accession>
    <name>B8MF27_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">(S)-2-hydroxy-acid oxidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_012350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483360.1">
        <property type="nucleotide sequence ID" value="XM_002483315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MF27"/>
    <dbReference type="STRING" id="441959.B8MF27"/>
    <dbReference type="GeneID" id="8104083"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_012350"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020639_1_1_1"/>
    <dbReference type="InParanoid" id="B8MF27"/>
    <dbReference type="OMA" id="ERYEMRM"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="PhylomeDB" id="B8MF27"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF104">
        <property type="entry name" value="CYTOCHROME B2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="4">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="5">
        <location>
            <begin position="103"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED16126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="493" mass="53643" checksum="18B06ECCC3562BE6" modified="2009-03-03" version="1">MEKEYNLGELGQHSKENDAWIAVNGEIWDMAGFGGIHPGGADVIYEYFGRDASEVYNEYHSPGLISKHLGPGKRIGRLQQTLQQNDTAPSISAIGSALAISKPPLTSMLNLYDFEEVAKSTFSDKSWAYISGASNDSWTMAANHDWYKRIMLRPRVLRDVSACRLETIIFGTKFGMPIFNAPASLVRMAHPEGELAIARGASALGSTMIIPMMSSYSTDEIVEEMPPDHPFLFQVYVHPDRKFTANLLQDVCSRLKPIAIIVTVDLPAFPKREANERLAIKKAMEAEKAAMGGKESAPPGSSTASKGQNQARSAGQNIASNLVWDDIEWIKKLTKLPVVLKGIQSAADAEKAYRLGCDGIYISNHGGRALDTSMPSILVLMEIQMTCPEILDKMEVFIDGGIRRGTDVLKAICLGAKGVCLGRPMFYAANYGSAGVEHALKLVADELQVAMQLVGINSLDEANPSFLNSLELQRYVSCGTNGRSALGAARSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFD8</accession>
    <name>B8MFD8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Globin-sensor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_017470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483906.1">
        <property type="nucleotide sequence ID" value="XM_002483861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFD8"/>
    <dbReference type="GeneID" id="8109004"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_017470"/>
    <dbReference type="eggNOG" id="ENOG502S0AP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063074_0_0_1"/>
    <dbReference type="InParanoid" id="B8MFD8"/>
    <dbReference type="OMA" id="YIHLGAC"/>
    <dbReference type="OrthoDB" id="10027058at2759"/>
    <dbReference type="PhylomeDB" id="B8MFD8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044398">
        <property type="entry name" value="Globin-sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071:SF1">
        <property type="entry name" value="GLOBIN-SENSOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071">
        <property type="entry name" value="PROTOGLOBIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11563">
        <property type="entry name" value="Protoglobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin-sensor" evidence="2">
        <location>
            <begin position="53"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED16672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="265" mass="30083" checksum="47A0CD674295E689" modified="2009-03-03" version="1">MPGTQSSCPVEVPIISEPTPSADATKSTASCPMKSWPRAIQHIDRKDLYTNLEDRIHYLHTFLDFSSNDIEALISGSKYIKALIPAVVNIVYRKLLQYDITARAFQTRSTSFEGPLDEFPSEDSPQIMHRKMFLRGYLVKLCSDPSKMEFWEYLDKVGMMHVGQGREHPLHVEYIHIGACLSFIQDTFTEAILSHPRMQLHRKIALVKALGKVIWIQNDLFAKWYVRDGAEYAGETAPAKIEQEGYLHGKKIFNESDDSSVGSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B8MFH0</accession>
    <name>B8MFH0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSTA_017780</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483938.1">
        <property type="nucleotide sequence ID" value="XM_002483893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MFH0"/>
    <dbReference type="FunCoup" id="B8MFH0">
        <property type="interactions" value="809"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MFH0"/>
    <dbReference type="GeneID" id="8109035"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_017780"/>
    <dbReference type="eggNOG" id="KOG0924">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_6_1_1"/>
    <dbReference type="InParanoid" id="B8MFH0"/>
    <dbReference type="OMA" id="VDVMFHR"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="PhylomeDB" id="B8MFH0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000018">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase prp16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000313">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="198"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="383"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="838"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="838"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="870"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="894"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EED16704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="926" mass="103581" checksum="19330B3940B8ED8D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGL3</accession>
    <name>B8MGL3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoglycerate mutase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_018350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483998.1">
        <property type="nucleotide sequence ID" value="XM_002483953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGL3"/>
    <dbReference type="FunCoup" id="B8MGL3">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MGL3"/>
    <dbReference type="GeneID" id="8100945"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_018350"/>
    <dbReference type="eggNOG" id="KOG0235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_13_0_1"/>
    <dbReference type="InParanoid" id="B8MGL3"/>
    <dbReference type="OMA" id="GWLIWRD"/>
    <dbReference type="OrthoDB" id="4818801at2759"/>
    <dbReference type="PhylomeDB" id="B8MGL3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050278">
        <property type="term" value="F:sedoheptulose-bisphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046390">
        <property type="term" value="P:ribose phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF15">
        <property type="entry name" value="SEDOHEPTULOSE 1,7-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="28"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="100"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED16764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="234" mass="25883" checksum="377BA065D2987CA5" modified="2009-03-03" version="1">MPDKDAGTPRVFIARHGETEWTKSGQYTGITELELTPTGETQVLNSGRVLVGAGKLIDPARIARVYVSPRKRAQKTCELLFSSSSSIDSDKVSTTERLAEWGYGEYEGMVTSQIRALRKEHGLDNERPWDIWQDGCEGGESAQQVTDRLDDLIKEIQSFHVNHMHGESGPADIVLVAHGHLLRAFVKRWLGYPMEFPLSLMLEPGGIGVLSYQHHNVGEPALFAGMAFPTPPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8MGM1</accession>
    <name>B8MGM1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_018430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484006.1">
        <property type="nucleotide sequence ID" value="XM_002483961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MGM1"/>
    <dbReference type="GeneID" id="8100953"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_018430"/>
    <dbReference type="eggNOG" id="ENOG502SBPR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036324_0_0_1"/>
    <dbReference type="InParanoid" id="B8MGM1"/>
    <dbReference type="OMA" id="QTDTMIE"/>
    <dbReference type="OrthoDB" id="2016523at2759"/>
    <dbReference type="PhylomeDB" id="B8MGM1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22189">
        <property type="entry name" value="PGAP4-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029675">
        <property type="entry name" value="PGAP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31410:SF1">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31410">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED16772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="49952" checksum="556DF0C72674D157" modified="2009-03-03" version="1">MKYSALTWVVNSIRLLLHLLVTTSAGKTFLASVFLFTLTFGWCKVRFWRDPHSAFFDDTHVYDLKYSLTREHEARQFISAYNAQTDGPPALKASPTPVVCVAVTTVKRDGVNYLDASVGSLLAGLYPQERSALSVNVLFADTDPRKHPSWEQQWLNSLVDSAASYNVSNEVMGRLRELEESRNYYEKGVYDYVYVLERCLQTNTPYIAIFEDDIIAADGWLAKSLMGLSTLGSRIGSEKTEKDWLYMRLFYTETSLSWSEDDFWYRNMPLAFLLMSSATLVILLIIRRVSTSARRFLNWPTIAVICLVSVPAFTGLVYMTGKYNVMPLQGVVEMNKHGCCTQGMIFPRDQVPDLIRWLEEHKSGQTDTLIEEYADSTGLRRFAYAPPQLQHVGSRSSRDNLDINTRSTWAFWFEENDPRVLAREHESLVQGGRVPWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B8MH73</accession>
    <name>B8MH73_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Peroxisomal carrier protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSTA_019490</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484121.1">
        <property type="nucleotide sequence ID" value="XM_002484076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MH73"/>
    <dbReference type="FunCoup" id="B8MH73">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MH73"/>
    <dbReference type="GeneID" id="8104644"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_019490"/>
    <dbReference type="eggNOG" id="KOG0769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_6_3_1"/>
    <dbReference type="InParanoid" id="B8MH73"/>
    <dbReference type="OMA" id="PLEMINT"/>
    <dbReference type="OrthoDB" id="446044at2759"/>
    <dbReference type="PhylomeDB" id="B8MH73"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015867">
        <property type="term" value="P:ATP transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF1">
        <property type="entry name" value="MITOCHONDRIAL THIAMINE PYROPHOSPHATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="10"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="118"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="211"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EED16887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="337" mass="36567" checksum="60823FE6B2C0EB90" modified="2009-03-03" version="1">MTGQSKPARLSPWGSAVAGATGAVLANALVYPLDIVKTKIQVQVKSRKDTSSNTEATPHYESTLDAINKIFQDEGLTGLYNGINGALIGVASTNFAYFYWYSVVRALYIASGRGSNTPGTAVELSLGAVAGAIAQIFTIPVSVVTTRQQTQSKDDKKGLLETAREVVDGEDGWTGLWRGLKASLVLVVNPAITYGAYQRLKEVLFPGKNNLRPWEAFVLGAMSKALATLATQPLIVAKVGLQSKPPPSRQGKPFKGFIEVMQYIIEHEGTLSLFKGIGPQIVKGLLVQGLLMMTKERMELAFILLFAYLRKFKEEKLKRYAERAAATAKTNLPVTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHB0</accession>
    <name>B8MHB0_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitochondrial integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_021460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED17089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002484323.1">
        <property type="nucleotide sequence ID" value="XM_002484278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHB0"/>
    <dbReference type="FunCoup" id="B8MHB0">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MHB0"/>
    <dbReference type="GeneID" id="8104391"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_021460"/>
    <dbReference type="eggNOG" id="ENOG502QQW9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028296_1_0_1"/>
    <dbReference type="InParanoid" id="B8MHB0"/>
    <dbReference type="OMA" id="ISRYCYW"/>
    <dbReference type="OrthoDB" id="164921at2759"/>
    <dbReference type="PhylomeDB" id="B8MHB0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019431">
        <property type="entry name" value="DUF2417"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10329">
        <property type="entry name" value="DUF2417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED17089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="524" mass="58629" checksum="A4FEAD48F6D511BA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>B8MHV4</accession>
    <name>B8MHV4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_015220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962656">
        <property type="protein sequence ID" value="EED16434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002483668.1">
        <property type="nucleotide sequence ID" value="XM_002483623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MHV4"/>
    <dbReference type="STRING" id="441959.B8MHV4"/>
    <dbReference type="GeneID" id="8106264"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_015220"/>
    <dbReference type="HOGENOM" id="CLU_824331_0_0_1"/>
    <dbReference type="InParanoid" id="B8MHV4"/>
    <dbReference type="OrthoDB" id="4934715at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED16434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="337" mass="37399" checksum="BE0364E2C1863AED" modified="2009-03-03" version="1">MYSPTTPLGRQTGYQILMGIGYGYTQQMRQAALSSICAADENYDVIAAYRARTALEGVWGYHAHFSIFVPLLEPGPGTAMASSSDGGDSSAVLETIQDKVNQLESPIIAFMGQSNVSITATRYRRKKDQDGENCCCGRESRRIASSNSLGSMHTDNKRMTYSEAAHWPTILEGKRFTQDPGLLLGPCGHATKPEILAAIPSRTVVNRLIFQYLQRLSIIQGAGTLNGRYLCRTDPTVNLSFKHFGKRSFNAYGWENPSMPSLHSQNVTTLSPSGFGLPRMIHAFQFDTAEPRNLVDSYFDTNIKDLPAARPDTEQTTVQYLVTKTRLKAMYFVKRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIK8</accession>
    <name>B8MIK8_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">FACT complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSTA_045590</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the FACT complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a stable heterodimer with POB3. The SPT16-POB3 dimer weakly associates with multiple molecules of NHP6 to form the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the peptidase M24 family. SPT16 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485053.1">
        <property type="nucleotide sequence ID" value="XM_002485008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIK8"/>
    <dbReference type="FunCoup" id="B8MIK8">
        <property type="interactions" value="1346"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MIK8"/>
    <dbReference type="GeneID" id="8107546"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_045590"/>
    <dbReference type="eggNOG" id="KOG1189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004627_1_0_1"/>
    <dbReference type="InParanoid" id="B8MIK8"/>
    <dbReference type="OMA" id="YHINTIP"/>
    <dbReference type="OrthoDB" id="10251642at2759"/>
    <dbReference type="PhylomeDB" id="B8MIK8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000002">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.210:FF:000001">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000017">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000006">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000005">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.210">
        <property type="entry name" value="FACT complex subunit Spt16p/Cdc68p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029148">
        <property type="entry name" value="FACT-SPT16_Nlobe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056595">
        <property type="entry name" value="Fact-SPT16_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048969">
        <property type="entry name" value="FACT_SPT16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013953">
        <property type="entry name" value="FACT_SPT16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040258">
        <property type="entry name" value="Spt16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980">
        <property type="entry name" value="CDC68 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980:SF15">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14826">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24824">
        <property type="entry name" value="PH_SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08644">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21091">
        <property type="entry name" value="SPT16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01285">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01286">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FACT complex subunit SPT16 N-terminal lobe" evidence="14">
        <location>
            <begin position="7"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="FACT complex subunit SPT16 middle" evidence="15">
        <location>
            <begin position="541"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="16">
        <location>
            <begin position="814"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="754"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="935"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="937"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="950"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="962"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="996"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EED15100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1019" mass="114500" checksum="6BE9DB0D10A2AF43" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MIZ5</accession>
    <name>B8MIZ5_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposable element tc1 transposase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_050950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485610.1">
        <property type="nucleotide sequence ID" value="XM_002485565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MIZ5"/>
    <dbReference type="STRING" id="441959.B8MIZ5"/>
    <dbReference type="GeneID" id="8109137"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_050950"/>
    <dbReference type="eggNOG" id="ENOG502QUTZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033666_0_1_1"/>
    <dbReference type="InParanoid" id="B8MIZ5"/>
    <dbReference type="OMA" id="STESHYE"/>
    <dbReference type="OrthoDB" id="4349822at2759"/>
    <dbReference type="PhylomeDB" id="B8MIZ5"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052338">
        <property type="entry name" value="Transposase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022:SF119">
        <property type="entry name" value="TC1-LIKE TRANSPOSASE DDE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022">
        <property type="entry name" value="TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13384">
        <property type="entry name" value="HTH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="2">
        <location>
            <begin position="104"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="3">
        <location>
            <begin position="159"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED15657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="355" mass="41484" checksum="16C794CD53C2DE4D" modified="2009-03-03" version="1">MATPEPTSPPRATSAAALEPSDSRQNSARLNRDERIRVLTLRDAGFTYLQISQQLQISYRQVQYTCQSQQATPKKARGNPPKLSEAEVDHIIEWITSSKRTRQLNLSIGKHALARALKKRGYTQCKALNKPPLSDKHRQVRLAWALEHLNWTTEQWNRILWSDETWVTSGFHTRIWVTRKAGEELEETCIRSSPARKRGWMFWATFHGNNKGPCLFWEREWGTINSERYCQRVIPIIDGYIRLLRDDIWLQFMQDGAPGHASKETLEELHSRGIYPIYWPAFSPDLNPIEAVWNWMKDWIQEQYPDDEQLSYDRLREVVRAAWDALPEQFLKELIDSMHARCQAVIDARGGHTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>B8MJM6</accession>
    <name>B8MJM6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS alpha-glucoside transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_051620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485678.1">
        <property type="nucleotide sequence ID" value="XM_002485633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MJM6"/>
    <dbReference type="STRING" id="441959.B8MJM6"/>
    <dbReference type="GeneID" id="8103383"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_051620"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="InParanoid" id="B8MJM6"/>
    <dbReference type="OMA" id="WAIIYQL"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="PhylomeDB" id="B8MJM6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF15">
        <property type="entry name" value="ALPHA-GLUCOSIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="8"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED15725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="514" mass="56643" checksum="30002B9E51E9D1F1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKG9</accession>
    <name>B8MKG9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Endoplasmic reticulum DnaJ domain protein Erj5, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSTA_047700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485277.1">
        <property type="nucleotide sequence ID" value="XM_002485232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKG9"/>
    <dbReference type="STRING" id="441959.B8MKG9"/>
    <dbReference type="GeneID" id="8099320"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_047700"/>
    <dbReference type="eggNOG" id="KOG0724">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037236_1_0_1"/>
    <dbReference type="InParanoid" id="B8MKG9"/>
    <dbReference type="OMA" id="RYIRHAR"/>
    <dbReference type="OrthoDB" id="413400at2759"/>
    <dbReference type="PhylomeDB" id="B8MKG9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052606">
        <property type="entry name" value="DnaJ_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877567" evidence="8">
        <location>
            <begin position="21"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="44"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="218"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="354"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="365"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EED15324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="407" mass="45217" checksum="6228D20B6073A426" modified="2009-03-03" version="1">MRHTAFQFLVVAILLAFVTAWTKEDHEIFQIRDELIAKEGPNVTFYDFLGVKPNANQDDINKAYRKMSRQLHPDKVKRSFIANSARKGDGKKKGTKPGVHVSKGPSERQIANAVKEATERSARLNTVANILRGPSRERYDHFMKHGFPTWKGTGYYYSRFRPGLGTVLIGLFVAFGGIGHYVALVLSYRRQREFMERYIRHARKAAWGDERALGGIPGLDATATTSPVSAPQAEVEESPAAMALNRRQKRMMERENRKESKKGSKNADSAPGSGTATPISENVAGASGTKKRVYAENGKILVVDSAGNVFLEEETEDGEKQQFLLDVEEIPQPVLRDTFVFRLPRWLYRRALGRKDAGESSEAVEGADDVDVNEGDALDAEVTKSTSTRSSAANAATRKRGKRGQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2023-06-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>B8MKP0</accession>
    <name>B8MKP0_TALSN</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_043600</name>
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    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED14889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002484797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MKP0"/>
    <dbReference type="GeneID" id="8097868"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_043600"/>
    <dbReference type="HOGENOM" id="CLU_1636546_0_0_1"/>
    <dbReference type="InParanoid" id="B8MKP0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED14889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="162" mass="19341" checksum="5089A52BEF3F5601" modified="2009-03-03" version="1">MCGKWISPDAPSAIFQVPTPVPKIASPAFDDGDYDVFEDYYQHKYIEYSVDDRNDDDDDNCSWRSYINFGYGSIYNYHGCCDYFANFGNDINYVNVNHRPQFDTIIYRDDLNRFIHEHCLDDHDDEFDEYFGDLDFERDMVVIMQLMIPKDDIFREYISYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLK9</accession>
    <name>B8MLK9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transcriptional corepressor Cyc8, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_049800</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CYC8/SSN6 family.</text>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002485450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLK9"/>
    <dbReference type="STRING" id="441959.B8MLK9"/>
    <dbReference type="GeneID" id="8108744"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_049800"/>
    <dbReference type="eggNOG" id="KOG1124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006762_2_1_1"/>
    <dbReference type="InParanoid" id="B8MLK9"/>
    <dbReference type="OMA" id="LYHQQSN"/>
    <dbReference type="OrthoDB" id="418911at2759"/>
    <dbReference type="PhylomeDB" id="B8MLK9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Corepressor-Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017:SF1">
        <property type="entry name" value="LD02225P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4 9" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="86"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="156"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="193"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="230"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="302"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="336"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="418"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="458"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="571"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="622"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="647"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="678"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="699"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="769"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="791"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="814"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED15542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="835" mass="91363" checksum="E2FACF763F59EABB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>B8MLM4</accession>
    <name>B8MLM4_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_049950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962657">
        <property type="protein sequence ID" value="EED15557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485510.1">
        <property type="nucleotide sequence ID" value="XM_002485465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MLM4"/>
    <dbReference type="STRING" id="441959.B8MLM4"/>
    <dbReference type="GeneID" id="8108759"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_049950"/>
    <dbReference type="eggNOG" id="ENOG502SQWB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_998112_0_0_1"/>
    <dbReference type="InParanoid" id="B8MLM4"/>
    <dbReference type="OMA" id="YALKRTH"/>
    <dbReference type="OrthoDB" id="4364812at2759"/>
    <dbReference type="PhylomeDB" id="B8MLM4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED15557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="279" mass="32023" checksum="118D0012715BAD9C" modified="2009-03-03" version="1">MPSDYALKRTHGQGTVIIHAADLYFLDQWKNDRAISDDAQRSAIFSKWLELGSRGRMPYVERLKEMCLNKYDITEDEKNLLARIRSASDRQGVSYTRLVRTFYGEGSEGNLAKLIFEAEYDGTVFDDAALYDAGSNDGLQSLHNILTHIPQIVEQTPEFAAWYNERKRKARDEAIEVGVDKLDYALSIFHLAAKWSHVLIYDKEANDGPGNVLLVYIDDRGCVLRYSWLDGAEDLQDADGMLCSGQDFMHAWWEGGRYGEDWEPHQLSKRWDEVDHENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>B8MM35</accession>
    <name>B8MM35_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Penicillin-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_098030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002485785.1">
        <property type="nucleotide sequence ID" value="XM_002485740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MM35"/>
    <dbReference type="STRING" id="441959.B8MM35"/>
    <dbReference type="GeneID" id="8108442"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_098030"/>
    <dbReference type="eggNOG" id="ENOG502SJKK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019706_0_0_1"/>
    <dbReference type="InParanoid" id="B8MM35"/>
    <dbReference type="OMA" id="ISKLWTM"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="PhylomeDB" id="B8MM35"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058664">
        <property type="entry name" value="ARB_00930-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051478">
        <property type="entry name" value="Beta-lactamase-like_AB/R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935:SF97">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935">
        <property type="entry name" value="PENICILLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26335">
        <property type="entry name" value="ARB_00930_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="84"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-like ARB-00930-like C-terminal" evidence="2">
        <location>
            <begin position="418"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED13547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="576" mass="63059" checksum="783CB2CAFB6D82AB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMR6</accession>
    <name>B8MMR6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_100660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486060.1">
        <property type="nucleotide sequence ID" value="XM_002486015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMR6"/>
    <dbReference type="STRING" id="441959.B8MMR6"/>
    <dbReference type="GeneID" id="8097950"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_100660"/>
    <dbReference type="eggNOG" id="ENOG502SH73">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007091_2_1_1"/>
    <dbReference type="InParanoid" id="B8MMR6"/>
    <dbReference type="OMA" id="INGCCEE"/>
    <dbReference type="OrthoDB" id="4225142at2759"/>
    <dbReference type="PhylomeDB" id="B8MMR6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED13822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="700" mass="79211" checksum="E18D545E4A85DF73" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8MMW9</accession>
    <name>B8MMW9_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rho GTPase Rac, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_101580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED13918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486156.1">
        <property type="nucleotide sequence ID" value="XM_002486111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MMW9"/>
    <dbReference type="STRING" id="441959.B8MMW9"/>
    <dbReference type="GeneID" id="8101846"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_101580"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_21_3_1"/>
    <dbReference type="InParanoid" id="B8MMW9"/>
    <dbReference type="OMA" id="RRMAPIT"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="PhylomeDB" id="B8MMW9"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000088">
        <property type="entry name" value="Ras-related C3 botulinum toxin substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED13918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="199" mass="21984" checksum="4EEE292289A68B7F" modified="2009-03-03" version="1">MASGPATQSLKCVVTGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSASVMVDGRPISLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSIVSPPSFDNVKAKWYPEIEHHAPGVPIILVGTKLDLREDRATAEALRAKKMEPVSYEQALAVAKEIRAHKYLECSALTQRNLKSVFDEAIRAVLNPRPQPKNKAKRCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B8MN67</accession>
    <name>B8MN67_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pogo transposable element, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_107230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486754.1">
        <property type="nucleotide sequence ID" value="XM_002486709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MN67"/>
    <dbReference type="GeneID" id="8103623"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_107230"/>
    <dbReference type="eggNOG" id="ENOG502S2ZX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_4_0_1"/>
    <dbReference type="InParanoid" id="B8MN67"/>
    <dbReference type="OMA" id="VYINHIT"/>
    <dbReference type="OrthoDB" id="3935526at2759"/>
    <dbReference type="PhylomeDB" id="B8MN67"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="3">
        <location>
            <begin position="16"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="158"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED14516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="509" mass="58323" checksum="54C25165109A9A52" modified="2009-03-03" version="1">MPPIRNKNSKNSAEQEGRILLAISDVKNGKLRSARQAAEIYNVSRSTLQNRLNGMAYRAETRANSHKLSKSEEESLVKWVGEKWVYNLIRRRPEIESKISRKYNYERAKCEDPKIIQEYFDRVREVVSEHGILQEDIYNFDETGFAMGLCATAKPGNREWVTAIEAVNSIGWALPSYIIFKAKKYTRLGWFEDLPDDWKINISDNGWTTDKIGLEWLKTHFIPLTDGRTLGKYRMLILDGHGSHLTPEFDRTCTENNIIPVCMPPYSSHLLQPLDVGCFAVLKRHYGQLVEQRMRLGFNHIDKIDFLTAFPKARTMAYKAQTVRNSFIATGLVPFNPDRVYQQLTVRLKTPTPPPSRSSDTQSSCLQTPQNLRQFKRQMTTTKKRISRHTRSSSEAIGEVFTRASKAYEMSINKLTIAQKELHDLRAAHEKEKQKRRRSKQQISHEQGITREEAQALVQGQIEVSQAVTTAPAEPELPVSHPPVRRQFRCSDCGVAGHKITGRPNRIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNC1</accession>
    <name>B8MNC1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_102400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486248.1">
        <property type="nucleotide sequence ID" value="XM_002486203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNC1"/>
    <dbReference type="GeneID" id="8100817"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_102400"/>
    <dbReference type="HOGENOM" id="CLU_127252_0_0_1"/>
    <dbReference type="InParanoid" id="B8MNC1"/>
    <dbReference type="OrthoDB" id="2976890at2759"/>
    <dbReference type="PhylomeDB" id="B8MNC1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED14010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="13384" checksum="7B388920BD4BF633" modified="2009-03-03" version="1">MEKVHVIHNILSKFNELALFVSKKKFQISLTVLIYYELHDLLDEASERKERFLDLDEDISLAVKEGMKKYKKYYTFMDTSDTYYTALILDPQIKDDLLLDKLEDKTTRREIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B8MNF1</accession>
    <name>B8MNF1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_102700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Could act as an H1-type linker histone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the histone H1/H5 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962658">
        <property type="protein sequence ID" value="EED14040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486278.1">
        <property type="nucleotide sequence ID" value="XM_002486233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MNF1"/>
    <dbReference type="STRING" id="441959.B8MNF1"/>
    <dbReference type="GeneID" id="8101104"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_102700"/>
    <dbReference type="eggNOG" id="KOG4012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052897_0_0_1"/>
    <dbReference type="InParanoid" id="B8MNF1"/>
    <dbReference type="OMA" id="IKNHYKV"/>
    <dbReference type="OrthoDB" id="1110759at2759"/>
    <dbReference type="PhylomeDB" id="B8MNF1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031492">
        <property type="term" value="F:nucleosomal DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000383">
        <property type="entry name" value="Histone H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467:SF36">
        <property type="entry name" value="HISTONE 24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="10">
        <location>
            <begin position="20"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="77"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED14040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="205" mass="21044" checksum="4249309E2066A4F0" modified="2009-03-03" version="1">MPPKKASTAASAASKKAAPSHASYRDMIKDAIINLKERNGSSRQSIKKYVQANNKITVVSPAAFDSQFNKAIKAGVEKGEFSQPKGPSGPVKLAKKEAAAKPVPKKPAAKPAAAAAAPKKAAAKKATSTTPAKPAKKATTTKKTATKPKANTAKPRKTSTAAPAIVDAPKVETKTKSGRVTKTTAKPAAKKAAPKKKATTKKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQ09</accession>
    <name>B8MQ09_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Single-stranded DNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_054110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487010.1">
        <property type="nucleotide sequence ID" value="XM_002486965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQ09"/>
    <dbReference type="FunCoup" id="B8MQ09">
        <property type="interactions" value="184"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MQ09"/>
    <dbReference type="GeneID" id="8100350"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_054110"/>
    <dbReference type="eggNOG" id="ENOG502S0M8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126647_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQ09"/>
    <dbReference type="OMA" id="TQYVRKG"/>
    <dbReference type="OrthoDB" id="1078367at2759"/>
    <dbReference type="PhylomeDB" id="B8MQ09"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000388">
        <property type="entry name" value="SsDNA binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="SINGLE-STRANDED DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302:SF0">
        <property type="entry name" value="SINGLE-STRANDED DNA-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002070">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR002070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED12899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="143" mass="15468" checksum="9ABF17485F7FF65F" modified="2009-03-03" version="1">MQAIRSSLRARAAVASVRSFSTTPSNSIARIIVTGRLAAEPEITATSTGQDVIKYVVGTSYGPRDNRQTSWFRVASFQPEGPGRDHLLSLPKGTLVYVEGDASMRVYEDAEGKKTSSLNIVQRTLEVLKRPHTASESGSEGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQ75</accession>
    <name>B8MQ75_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Queuosine 5'-phosphate N-glycosylase/hydrolase</fullName>
            <ecNumber evidence="6">3.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 6">Queuosine-nucleotide N-glycosylase/hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_056450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>queuosine 5'-phosphate + H2O = queuine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:75387"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:194371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5 6">
            <dbReference type="Rhea" id="RHEA:75388"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the QNG1 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="6"/>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487255.1">
        <property type="nucleotide sequence ID" value="XM_002487210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQ75"/>
    <dbReference type="STRING" id="441959.B8MQ75"/>
    <dbReference type="GeneID" id="8100708"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_056450"/>
    <dbReference type="eggNOG" id="KOG2524">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036001_2_1_1"/>
    <dbReference type="InParanoid" id="B8MQ75"/>
    <dbReference type="OMA" id="FSFWSEE"/>
    <dbReference type="OrthoDB" id="416777at2759"/>
    <dbReference type="PhylomeDB" id="B8MQ75"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019438">
        <property type="entry name" value="Q_salvage"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314:SF0">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10343">
        <property type="entry name" value="Q_salvage"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="346"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="349"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED13144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="425" mass="49422" checksum="EB055C1D48183225" modified="2009-03-03" version="1">MSDDEADPELLELLRQSLGLGKKTGNEPPETKVLQNARWIFDNSIDVALDTRQTKAAAETIWQQIQQKQYSTSTWSGHELHPKAKNEKTVDFIFTMDLLNFSFWSEEKDESKRFGIEYLGRKWTGYWSLVAALQRALDEGIPITTPDFWLNEEEFTEDLLRHVFRSTSEEEIPLLKERFDCMREAGQILDEKFDGSFVNCIYDANKSAAALVNLLADEFSCFRDEASFDGRTVRFYKRAQILVADLWACFDGESYGEFNDIDKITMFADYRIPQMLHQLGCLLYSPPLESHIRRREPIKSGSKWEMELRGTSIWCVELIRQEIERTRPETRMVYSTGNSSTFEVNIDDQQDKEVTETTTELHKLQEHGEKEKTETKTESKSSTPQEKTIGVNAILIDFFLYDSMKELESDGKESIPHHRTRSIWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQI0</accession>
    <name>B8MQI0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-CoA hydrolase</fullName>
            <ecNumber evidence="4">3.1.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetyl-CoA deacylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSTA_058710</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O = acetate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20289"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="3.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyl-CoA hydrolase/transferase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.1" evidence="4"/>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487493.1">
        <property type="nucleotide sequence ID" value="XM_002487448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQI0"/>
    <dbReference type="FunCoup" id="B8MQI0">
        <property type="interactions" value="237"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MQI0"/>
    <dbReference type="GeneID" id="8106473"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_058710"/>
    <dbReference type="eggNOG" id="KOG2828">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019748_3_0_1"/>
    <dbReference type="InParanoid" id="B8MQI0"/>
    <dbReference type="OMA" id="SCIVPMV"/>
    <dbReference type="OrthoDB" id="10250396at2759"/>
    <dbReference type="PhylomeDB" id="B8MQI0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003986">
        <property type="term" value="F:acetyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.70:FF:000002">
        <property type="entry name" value="Acetyl-CoA hydrolase Ach1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000003">
        <property type="entry name" value="Acetyl-coA hydrolase Ach1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.20:FF:000001">
        <property type="entry name" value="Acetyl-CoA hydrolase Ach1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.70">
        <property type="entry name" value="4-hydroxybutyrate coenzyme like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="entry name" value="Acetyl-CoA hydrolase/transferase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046433">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43609">
        <property type="entry name" value="ACETYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43609:SF1">
        <property type="entry name" value="ACETYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase N-terminal" evidence="9">
        <location>
            <begin position="14"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase C-terminal" evidence="10">
        <location>
            <begin position="332"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EED13382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="524" mass="58124" checksum="7419D6A6DCCB0D2B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQL6</accession>
    <name>B8MQL6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_059250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487550.1">
        <property type="nucleotide sequence ID" value="XM_002487505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQL6"/>
    <dbReference type="GeneID" id="8107395"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_059250"/>
    <dbReference type="eggNOG" id="ENOG502QQ7T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_997850_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQL6"/>
    <dbReference type="OMA" id="TTFKPCS"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="303" mass="30205" checksum="DFD2D629994931F7" modified="2009-03-03" version="1">MPKMGHDPRPGLGICLDCLVEMRSVLVNAVLIGSALAYPGYWAERRHYGTGVPPPLSTGVNPPPPPPVTSTITSVTPATTTTTGTGEWSTATQTETITKTTFVPCSTSVGTRGSSTVWSTWLSSTTTCWTSTWTTVVPVTTSTATATVVPVAPGGGNTCPLPVTTTHTETTTATVTVTAPAITVTATAPAPGGGETTTTTVVPPAPPAEGTSTATVTGTHTGTATHTHPATATGTETGTAPGGGAQPTTSTLTTTTTEPCTTTTTTSTGIVGTGGTTTSTSTGPVGTGGVTGHKWSMRKPLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQR1</accession>
    <name>B8MQR1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_052150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486802.1">
        <property type="nucleotide sequence ID" value="XM_002486757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQR1"/>
    <dbReference type="GeneID" id="8106805"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_052150"/>
    <dbReference type="eggNOG" id="ENOG502T5RB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1120471_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQR1"/>
    <dbReference type="OMA" id="HILFMHQ"/>
    <dbReference type="OrthoDB" id="4795535at2759"/>
    <dbReference type="PhylomeDB" id="B8MQR1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED12691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="30596" checksum="AF618850009B6D53" modified="2009-03-03" version="1">MNNYKEVAYQLENLEDESAPFLTMGRRFKFTKRSVPPRPPPPRLVPKPELPLRDESLGSSMSENDVQEVLHSAATEFKPISTTYGPFDLFAAIDPVTGDSVVHRAASVGNTQFLSGLLGCWGRRCGNDKKPLGSFWVLMTHQNLAGDTALHAAARHGSLQGAKAVYRLLHCGFVHDEEHDEENPPPEEWEWDFQEDLIFVYKAVIFVCAKNKDGLDAAALAQESGNNALIKWFEDLLRRIDPDGKRNDDSYIKGAWTMVLKHYGYYIKDIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQT1</accession>
    <name>B8MQT1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pogo transposable element, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_052510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486839.1">
        <property type="nucleotide sequence ID" value="XM_002486794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQT1"/>
    <dbReference type="GeneID" id="8098200"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_052510"/>
    <dbReference type="eggNOG" id="ENOG502S2ZX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_4_0_1"/>
    <dbReference type="InParanoid" id="B8MQT1"/>
    <dbReference type="OrthoDB" id="4457643at2759"/>
    <dbReference type="PhylomeDB" id="B8MQT1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="107"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED12728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="447" mass="51689" checksum="C4E5A790B4430F94" modified="2009-03-03" version="1">MADYLLSQRGNQQVGEKWVYNLIRRRPELESKFSRKYNYERAKCEDPKIIQEYFDRVREVVSEHGILQEDIYNFDETGFAMGLCATARVITGIDRYNRPNLLQPGDREWVTAIEAVNSIGWALPSYIIFKAKKYTRLGWFEDLPDDWKINISDNGWTTDKIGLEWLKTHFIPLIDGRTLGKYRMLILDGHGSHLTPEFNRTCTENNIIPVCMPPHSSHLLRPLDVGCFAVLKRHYGQLVERRMRLGFNHIDKLDFLTAFPKARTMAYKAQTVRTSFTAIGLVTFNPDRVYQQLTIRLKTPTPPPSRSSDTQSSCLQTPQNPRQFKRQMTTTKKRISRHTRSSSEAIGEVFTRTSKAYEMSINKLTIAQKELHDLRAAHEKEKQKRRRSKQQISHEQGITREEAQALVQGQIEASQAVTTAPAEPELPVSHPPKFMFKINIERVLGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQV1</accession>
    <name>B8MQV1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_053040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486897.1">
        <property type="nucleotide sequence ID" value="XM_002486852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQV1"/>
    <dbReference type="STRING" id="441959.B8MQV1"/>
    <dbReference type="GeneID" id="8098253"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_053040"/>
    <dbReference type="eggNOG" id="ENOG502SP01">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015771_4_0_1"/>
    <dbReference type="InParanoid" id="B8MQV1"/>
    <dbReference type="OMA" id="QTWAFPF"/>
    <dbReference type="OrthoDB" id="3469466at2759"/>
    <dbReference type="PhylomeDB" id="B8MQV1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED12786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="559" mass="63252" checksum="D841F17DA5981B8E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>B8MQY2</accession>
    <name>B8MQY2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_053350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002486928.1">
        <property type="nucleotide sequence ID" value="XM_002486883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MQY2"/>
    <dbReference type="STRING" id="441959.B8MQY2"/>
    <dbReference type="GeneID" id="8098286"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_053350"/>
    <dbReference type="eggNOG" id="ENOG502QPXZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014819_0_0_1"/>
    <dbReference type="InParanoid" id="B8MQY2"/>
    <dbReference type="OMA" id="MELLPEH"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="PhylomeDB" id="B8MQY2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF2">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED12817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="302" mass="33945" checksum="C7C65E94E836648A" modified="2009-03-03" version="1">MHGSVMLAKVLTEVYYGKMPGYNYYSGCSTGGRQGLKEVEIYHEDSMELLPEHRLGGQHICKYGLEGFLCKGSSSSSSADCLSAAQLHTLYDIYNDYVDINQTFVFPHLLPGRESQWAEVIINSSNSPLGYEYVQYFLGMGPQWSPNQFDYSIRKGGKLLMYHGMADGFNPTETSIASSMCRAFSIYPFRILNLYDRHCRGSPDSMHAPWYFAGPNQASHPSSSLHSVPWYADAQHDILLALIECVGKGVATDSITATTCHNDTTQSEVYRQRPLCVYPKKAFYKGHGDPDLAKNWECRDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>B8MR86</accession>
    <name>B8MR86_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Homoserine O-acetyltransferase, putative</fullName>
            <ecNumber evidence="6">2.3.1.175</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_054900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.175" evidence="6"/>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487092.1">
        <property type="nucleotide sequence ID" value="XM_002487047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MR86"/>
    <dbReference type="FunCoup" id="B8MR86">
        <property type="interactions" value="145"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MR86"/>
    <dbReference type="MEROPS" id="S33.A41"/>
    <dbReference type="GeneID" id="8100496"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_054900"/>
    <dbReference type="eggNOG" id="ENOG502QRIX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028760_5_0_1"/>
    <dbReference type="InParanoid" id="B8MR86"/>
    <dbReference type="OMA" id="EWPLNTP"/>
    <dbReference type="OrthoDB" id="191364at2759"/>
    <dbReference type="PhylomeDB" id="B8MR86"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033813">
        <property type="term" value="F:deacetylcephalosporin-C acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF11">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="68"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="251"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED12981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="492" mass="54072" checksum="FFEC0638BCB0BFA1" modified="2009-03-03" version="1">MSDTKEASASAPMKYQRVASQPENPFSQLISKQEIAIIPSFTLESGDTLYNAPVAYTVRGQLSPNGDNALVICHALSGSADVADWWGPLLGKQGQAFDITRFYVVCLNSLGSPYGSASAVTYRDGDSTKGRYGPEFPLTTIRDDVRIHKLVLDDLGVKQIAAVVGGSMGGMLTLEYAYFGKDYVRAIVPIATSARHSAWCISWSEAQRQSIYSDPKYEDGYYSFDDPPATGLGAARMSALLTYRSRNSFESRFGRNVPDPSKRQNINCTTGPPSPPSEHWAIHNDGHKSSRASRPSSQTGSPKRPTEIEFTDPQFNGTTTFTAQLPTPKHSRPSTYFSAQSYLRYQGEKFVKRFDSNCYIAITRKLDTHDVSRHRASPDSPSPVKDALSQIEQPALVMGIESDGLFTFEEQQEIAAGIPDSRLKKIDSPEGHDAFLLQFQQVNTYILEFFREVLPDIMSKPGESGDASADSVGELTKSSTFGEAEVDDITAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B8MR94</accession>
    <name>B8MR94_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF300 domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_054960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED12989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487100.1">
        <property type="nucleotide sequence ID" value="XM_002487055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MR94"/>
    <dbReference type="STRING" id="441959.B8MR94"/>
    <dbReference type="GeneID" id="8100502"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_054960"/>
    <dbReference type="eggNOG" id="KOG2641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_330146_0_0_1"/>
    <dbReference type="InParanoid" id="B8MR94"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="PhylomeDB" id="B8MR94"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="561"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="598"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="642"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="740"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="809"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="859"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED12989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="869" mass="97877" checksum="19F2DFF218497228" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRG4</accession>
    <name>B8MRG4_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_056010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487212.1">
        <property type="nucleotide sequence ID" value="XM_002487167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRG4"/>
    <dbReference type="STRING" id="441959.B8MRG4"/>
    <dbReference type="ESTHER" id="talsn-b8mrg4">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="8100666"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_056010"/>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_10_3_1"/>
    <dbReference type="InParanoid" id="B8MRG4"/>
    <dbReference type="OMA" id="SIAHHIM"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="PhylomeDB" id="B8MRG4"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000263">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="86"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED13101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="622" mass="68728" checksum="EC4664B4FB69C40D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRK1</accession>
    <name>B8MRK1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin B1 interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_056590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487269.1">
        <property type="nucleotide sequence ID" value="XM_002487224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRK1"/>
    <dbReference type="STRING" id="441959.B8MRK1"/>
    <dbReference type="GeneID" id="8100722"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_056590"/>
    <dbReference type="eggNOG" id="ENOG502RMFV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049340_0_0_1"/>
    <dbReference type="InParanoid" id="B8MRK1"/>
    <dbReference type="OrthoDB" id="441210at2759"/>
    <dbReference type="PhylomeDB" id="B8MRK1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042448">
        <property type="entry name" value="CCNB1IP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14305">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CCNB1IP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14305:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CCNB1IP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="109"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="33706" checksum="152CB346727E03AC" modified="2009-03-03" version="1">MAQSLGFSLRCNSLTCRKTLNDRAAVTTSCAETLGLAPQTQKNRICPACQANLRNPDDVVSTVLNPTEDYKTSVLGGLDPTMIIECAGRALSFWAYQTTQEICYQEYLSKGLTEKYSNLNTEKEKLINSANAEISSLQNKLADMQMAQDQLQKRNDELIALYHEKCKKHTQMTNLYNLLKSRAMPSQIQAATAASRHFDALPSTERRNVKHSTEQLFWHQRSGSASSKIREDRFIADTGPMPPPQFSFSVAQNAMTTPSLHRTCLPAQPGSAVLRESRGLAEEPKYFVNHGRYRDFSYNPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRP0</accession>
    <name>B8MRP0_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biogenesis of lysosome-related organelles complex 1 subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_056940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BLOC1S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487308.1">
        <property type="nucleotide sequence ID" value="XM_002487263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRP0"/>
    <dbReference type="STRING" id="441959.B8MRP0"/>
    <dbReference type="GeneID" id="8109925"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_056940"/>
    <dbReference type="eggNOG" id="ENOG502S9ZX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092507_0_0_1"/>
    <dbReference type="InParanoid" id="B8MRP0"/>
    <dbReference type="OMA" id="WCAKLSI"/>
    <dbReference type="OrthoDB" id="20018at2759"/>
    <dbReference type="PhylomeDB" id="B8MRP0"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009395">
        <property type="entry name" value="BLOC1S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13073:SF0">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13073">
        <property type="entry name" value="BLOC-1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06320">
        <property type="entry name" value="GCN5L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="161"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="226"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED13197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="285" mass="31150" checksum="5443EA1F40FA3ED8" modified="2009-03-03" version="1">MPAPQKPSTERSPTHAASSLTSPQPATATATATATTTHQSSSSSVLSPTTANQPRDPQEAVRHTLEARTAFTASLHSVGQTVSADLRARAVDLHENAAVIQKQENVLAKHTAELSKQNDQWDKVVDTARQGLKEIGDVQNWAEMIERDLLVVEEVLRLVEGEEGHEGEDDRVRREEEGYHEEQLRDGLHEEEDGDLTERENGDRKKVTQEPVDVLDDVLSSASGITGTSATSGAISESSGKISPRDQDGGQQQIKTIGDTKKSAGGWWKWWCAKLSIIVIWSIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B8MRR1</accession>
    <name>B8MRR1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_057140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962659">
        <property type="protein sequence ID" value="EED13218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487329.1">
        <property type="nucleotide sequence ID" value="XM_002487284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MRR1"/>
    <dbReference type="GeneID" id="8109945"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_057140"/>
    <dbReference type="eggNOG" id="KOG0379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017138_1_1_1"/>
    <dbReference type="InParanoid" id="B8MRR1"/>
    <dbReference type="OMA" id="LCGQEWP"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="PhylomeDB" id="B8MRR1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="86"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED13218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="626" mass="71581" checksum="D0CE93FFE77149AF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>B8MS68</accession>
    <name>B8MS68_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSTA_001940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002487780.1">
        <property type="nucleotide sequence ID" value="XM_002487735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MS68"/>
    <dbReference type="GeneID" id="8098785"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_001940"/>
    <dbReference type="eggNOG" id="ENOG502QTTH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014663_1_0_1"/>
    <dbReference type="InParanoid" id="B8MS68"/>
    <dbReference type="OMA" id="MWGALDS"/>
    <dbReference type="OrthoDB" id="5819478at2759"/>
    <dbReference type="PhylomeDB" id="B8MS68"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36851:SF1">
        <property type="entry name" value="GLYCO_TRANS_2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36851">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002877743" description="Glycosyltransferase 2-like domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="448"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="486"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="3">
        <location>
            <begin position="259"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EED12126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="598" mass="66299" checksum="F68CBDDC539B8BD3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTC1</accession>
    <name>B8MTC1_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="8">ATase</shortName>
            <ecNumber evidence="3 8">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSTA_004200</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="3 8"/>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488025.1">
        <property type="nucleotide sequence ID" value="XM_002487980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTC1"/>
    <dbReference type="FunCoup" id="B8MTC1">
        <property type="interactions" value="730"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MTC1"/>
    <dbReference type="MEROPS" id="C44.001"/>
    <dbReference type="GeneID" id="8100131"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_004200"/>
    <dbReference type="eggNOG" id="KOG0572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022389_2_1_1"/>
    <dbReference type="InParanoid" id="B8MTC1"/>
    <dbReference type="OMA" id="IRHFGVK"/>
    <dbReference type="OrthoDB" id="191723at2759"/>
    <dbReference type="PhylomeDB" id="B8MTC1"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046083">
        <property type="term" value="P:adenine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11907">
        <property type="entry name" value="AMIDOPHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 8 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="12">
        <location>
            <begin position="2"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EED12371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="543" mass="59516" checksum="782C9FF9A80C3CA1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>B8MTS8</accession>
    <name>B8MTS8_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSTA_005930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962660">
        <property type="protein sequence ID" value="EED12563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488217.1">
        <property type="nucleotide sequence ID" value="XM_002488172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MTS8"/>
    <dbReference type="GeneID" id="8105566"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_005930"/>
    <dbReference type="HOGENOM" id="CLU_101891_0_0_1"/>
    <dbReference type="InParanoid" id="B8MTS8"/>
    <dbReference type="OrthoDB" id="4486039at2759"/>
    <dbReference type="PhylomeDB" id="B8MTS8"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EED12563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="165" mass="18715" checksum="4F8C3D964AF99A92" modified="2009-03-03" version="1">MPRVSQLPEEVLANLREDRLLSYMEEFDKADPEAIFEKTYIEEESVKEAEENLNTPGGNQKEELTRLKKEVKEARREAKQNADNIIELQGERDQYMQAFAKLHLQTGGRGDSEEGTPRPTLTPKSTKLPKGAKLSDGVNPTFESWLIDVEGTLKSNADYYPNAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MU80</accession>
    <name>B8MU80_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSTA_107750</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488340.1">
        <property type="nucleotide sequence ID" value="XM_002488295.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MU80"/>
    <dbReference type="GeneID" id="8106851"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_107750"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001650_5_0_1"/>
    <dbReference type="InParanoid" id="B8MU80"/>
    <dbReference type="OMA" id="CIDYCTE"/>
    <dbReference type="OrthoDB" id="3799035at2759"/>
    <dbReference type="PhylomeDB" id="B8MU80"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="18">
        <location>
            <begin position="625"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="260"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="942"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1074"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="950"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="961"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EED11584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1638" mass="185293" checksum="FCCF49CFD4AFE8AD" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUF3</accession>
    <name>B8MUF3_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSTA_109720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488548.1">
        <property type="nucleotide sequence ID" value="XM_002488503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUF3"/>
    <dbReference type="STRING" id="441959.B8MUF3"/>
    <dbReference type="GeneID" id="8107204"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109720"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022195_9_2_1"/>
    <dbReference type="InParanoid" id="B8MUF3"/>
    <dbReference type="OMA" id="KNIPWVL"/>
    <dbReference type="OrthoDB" id="4219677at2759"/>
    <dbReference type="PhylomeDB" id="B8MUF3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EED11792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="477" mass="55063" checksum="E6C44EE2DD827089" modified="2009-03-03" version="1">MAVYAIWSFVTVLTLLNLHYLRRGAKWKSGKGFEKSTTVFWLGRGSGLFADARSKLGAFIYGRQLFADAYSKCSSKNEIVKISTISVPLVLVPKTHRKWFFKEKSDVLDHRATGFDAVESLYTMPCGHILDFPTHVKLIHRILTRELPNLTDDLVEEIEDGIQKYWGSDTESCRSVDVWETVLMLVTRTFNRISVGKPLCADEGYLNNTRRYVTSIHAMSAIIRVFPSWAKHLVGPILSIPCWYYYWRGKRYAMPLIHKYLEKARMDPDKCEGFSNKPNVFAMWIVQEALHSQIPREMNPETIYARLMTMNFAGIHTSSFTTVNMLLDSLSRPDIFKDMEEEVRKTYHYHGDKWTQPAVNQLKYTDNVLRESMRLSGPIIRLLREVKAKNGIEINGVPLPQGTKIAIDMHNMHRDEEIYKDATVFDPLRFNPSTGREMPATTKTSENFLPFGHGRMPWPLLCKSRDKANRCDDHHEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUF6</accession>
    <name>B8MUF6_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_109750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488551.1">
        <property type="nucleotide sequence ID" value="XM_002488506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUF6"/>
    <dbReference type="STRING" id="441959.B8MUF6"/>
    <dbReference type="GeneID" id="8107207"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_109750"/>
    <dbReference type="eggNOG" id="ENOG502TBTA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048480_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUF6"/>
    <dbReference type="OMA" id="IPYLQEC"/>
    <dbReference type="OrthoDB" id="4312812at2759"/>
    <dbReference type="PhylomeDB" id="B8MUF6"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="1">
        <location>
            <begin position="349"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED11795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="519" mass="59064" checksum="4B81F0E3BE7052B3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUU2</accession>
    <name>B8MUU2_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DEAD/DEAH box helicase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_110420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488618.1">
        <property type="nucleotide sequence ID" value="XM_002488573.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MUU2"/>
    <dbReference type="GeneID" id="8107274"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_110420"/>
    <dbReference type="eggNOG" id="KOG0949">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002305_2_0_1"/>
    <dbReference type="InParanoid" id="B8MUU2"/>
    <dbReference type="OMA" id="GYFHRLC"/>
    <dbReference type="OrthoDB" id="2320933at2759"/>
    <dbReference type="PhylomeDB" id="B8MUU2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18025">
        <property type="entry name" value="DEXHc_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001039">
        <property type="entry name" value="ATP-dependent RNA helicase DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055124">
        <property type="entry name" value="PIN-like_DDX60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052431">
        <property type="entry name" value="SKI2_subfamily_helicases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059032">
        <property type="entry name" value="WHD_DDX60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533">
        <property type="entry name" value="DEAD/H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533:SF4">
        <property type="entry name" value="DEAD_H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23002">
        <property type="entry name" value="PIN-like_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26076">
        <property type="entry name" value="WHD_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="790"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="554"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="574"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED11862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1845" mass="208633" checksum="FDF6BD213DB75B5A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUY7</accession>
    <name>B8MUY7_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_110080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488584.1">
        <property type="nucleotide sequence ID" value="XM_002488539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MUY7"/>
    <dbReference type="STRING" id="441959.B8MUY7"/>
    <dbReference type="GeneID" id="8107240"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_110080"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_909669_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUY7"/>
    <dbReference type="OrthoDB" id="4362013at2759"/>
    <dbReference type="PhylomeDB" id="B8MUY7"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED11828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="35275" checksum="78E7422C5D26F63A" modified="2009-03-03" version="1">MALANTEPTKDVQVVGIGATKTGYVIRFRDAQLAETTQENSAWLEELRNDIKLVKPRFDREKKEGIAKITEENDLAEKGFKIEDIVWLKKKDRPLERLASIGVWFNTLEKFGHLAWLCKEQVKCSHCSSQHEQRYYPPGIRLRILEMPNTSEPKRIPIMTTTLHLLQLNIWKSRAGMEALINDHQSQSLDLLLIQELSITTYCTHVNHSAWQLYQSTYPNTESTRFRSLLYVNKRILTSSHQQIHCNHPDLVAIKIWTAAIQFLVFSVYIPLLDVHEAANITAAESALEEIKTTIEQHTRETDKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>B8MUZ3</accession>
    <name>B8MUZ3_TALSN</name>
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        <submittedName>
            <fullName evidence="5">WD repeat-containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_110140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962661">
        <property type="protein sequence ID" value="EED11834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488590.1">
        <property type="nucleotide sequence ID" value="XM_002488545.1"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8MUZ3"/>
    <dbReference type="GeneID" id="8107246"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_110140"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0271">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_248005_0_0_1"/>
    <dbReference type="InParanoid" id="B8MUZ3"/>
    <dbReference type="OMA" id="WTIRLWR"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="PhylomeDB" id="B8MUZ3"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="605"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="647"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="689"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="730"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="772"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="813"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="855"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="896"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="938"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="979"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1021"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1063"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1211"/>
            <end position="1231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED11834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="1515" mass="165723" checksum="A43BDF0D72E05290" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B8MVJ6</accession>
    <name>B8MVJ6_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Florfenicol exporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSTA_080370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao H."/>
                <person name="Waite J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ATCC 10500</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962664">
        <property type="protein sequence ID" value="EED11423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ962664">
        <property type="protein sequence ID" value="EED11424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488833.1">
        <property type="nucleotide sequence ID" value="XM_002488788.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002488834.1">
        <property type="nucleotide sequence ID" value="XM_002488789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8MVJ6"/>
    <dbReference type="STRING" id="441959.B8MVJ6"/>
    <dbReference type="GeneID" id="8108960"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_080370"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_1_3_1"/>
    <dbReference type="InParanoid" id="B8MVJ6"/>
    <dbReference type="OMA" id="FARTNSE"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="33"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EED11423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="478" mass="52412" checksum="31903933BCAB311C" modified="2009-03-03" version="1">MTEVGPFVPEEVNFAPNDPEYPKNWPDSRKFFIVLLVSGFGFLTPATSSMVAPALDQIATDLHITNSAESQLILSIFLLGLGVGPLLLGPLSEIYGRAPVIRWGNLFYLVFNTAGGFARTNSEMLIFRLLAGVGGSAPLVVGSGVISDCYHPEQRGFAVSIYNIVPLLGPALGPIAGAFITQSISWRWVFFIVSLADVTLQLMAAVVLRETYPPVLLEHRKSLLFESTGNPNLRTPYDNERSRDLRTVLRQSLFRCLQLLVTQPILQVLAIYLAYVYGLIYLVFSTFPSVWETQYHQSSTIGSLNYISLGLGYLSGSLICAVFVDRIYGELKARNDGRTEPEYRVPIMAAASLLVPVGIVLYGWSAGKSLFWLITDIGGFIFSCGIIMIMQSVNNYVLDAYPLYAASAIGAVTVVRNIPGVVFPLFAPYLYDAVGFGWGGSLLALVAVCIGFPAPVIIWIYGRRLRISSQFASNNERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>B8LT34</accession>
    <name>B8LT34_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polyadenylation factor subunit CstF64, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSTA_069600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002340929.1">
        <property type="nucleotide sequence ID" value="XM_002340888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LT34"/>
    <dbReference type="FunCoup" id="B8LT34">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="441959.B8LT34"/>
    <dbReference type="GeneID" id="8107322"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_069600"/>
    <dbReference type="eggNOG" id="KOG0108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028601_0_1_1"/>
    <dbReference type="InParanoid" id="B8LT34"/>
    <dbReference type="OMA" id="CEPEDAP"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="PhylomeDB" id="B8LT34"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.630:FF:000003">
        <property type="entry name" value="Polyadenylation factor subunit CstF64, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000219">
        <property type="entry name" value="Putative polyadenylation factor subunit CstF64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.70">
        <property type="entry name" value="Transcription termination and cleavage factor, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025742">
        <property type="entry name" value="CSTF2_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026896">
        <property type="entry name" value="CSTF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038192">
        <property type="entry name" value="CSTF_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
        <property type="entry name" value="CSTF2_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14304">
        <property type="entry name" value="CSTF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="7"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="83"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EED23542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="302" mass="32550" checksum="894F8C4DB37FAE86" modified="2009-03-03" version="1">MAPGMGKSVFLGNIPYNLTEEQVKDILSTAGTVTKFRLMMNPETGKPKGYGFADFADADAAASAVRNLNDYEIMGRKIRVDWPHNNEKDSIPEDYSDPYQPQPSQPQAQAQQQQQNPSSLPPLPPGVEIPPHLDCPNAISQTLSQLPPNQLLDVLSQMKALAVADPARATELLRTAPQLAYAVFQALLLMNLVDYSTLGSVVEQASQAATGPPPPAAAAVPYQPYTTAPTQVSTPPVHNSPFAPPPPPPAAAGALPQQQIPGQEELLQQVLSMPQAQIDALPPLERSQIMMLRQQLMQSGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUC2</accession>
    <name>B8LUC2_TALSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ca2+-modulated nonselective cation channel polycystin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSTA_070980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED23695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002341082.1">
        <property type="nucleotide sequence ID" value="XM_002341041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUC2"/>
    <dbReference type="STRING" id="441959.B8LUC2"/>
    <dbReference type="GeneID" id="8105648"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_070980"/>
    <dbReference type="eggNOG" id="ENOG502SFF8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035522_0_0_1"/>
    <dbReference type="InParanoid" id="B8LUC2"/>
    <dbReference type="OMA" id="AKNNPYP"/>
    <dbReference type="OrthoDB" id="5377012at2759"/>
    <dbReference type="PhylomeDB" id="B8LUC2"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EED23695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="48598" checksum="9A8657C4922C74C7" modified="2009-03-03" version="1">MAMAETSDPPHVRHSRRKPFSTWMKRLTNLKSSSSSGTQSGSREASGKGNVHNNILKSGNKRQNGCAKNNPYPLSGTIRDIGSPRSYNDTVSYTESTETDQHRLDQSASQHSLQASASEQNIPGNSAKSTAPTLSTMGDTARSETGYSKAGTTMTGPGGVYGGGEGSTFSSPAPSVRSLTTTLTTVQSAAPSAHIYGIAQNNQNINGPISSAQNGLQQQTQFAHQFPPSPASAVPPHVAMTGHPTTYSSATANNILTDNASILTLASSSKRRRRNSLDTNASMRALAPSSVFGGSRESLPLSVLSANVGADASNASITNASGVLSRQSLGGLASAERISVYSASGTVPPLVHGGGDRSSLIAAGKQGDNGSIRSGTHSHTRNDSAAGSVSGTIGSTLNNNTSAAAAITPGAMPGRISRRSSGWGEISGEGEEGGAHQRCEIDESSEKTEEANQENSLANGDPESSIDEKAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2025-04-02" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B8LUZ1</accession>
    <name>B8LUZ1_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cortactin-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSTA_061030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ962652">
        <property type="protein sequence ID" value="EED22612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002339999.1">
        <property type="nucleotide sequence ID" value="XM_002339958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LUZ1"/>
    <dbReference type="STRING" id="441959.B8LUZ1"/>
    <dbReference type="GeneID" id="8101237"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_061030"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_402842_0_0_1"/>
    <dbReference type="InParanoid" id="B8LUZ1"/>
    <dbReference type="OMA" id="EMHAIQL"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="PhylomeDB" id="B8LUZ1"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="172"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="205"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="600"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="18"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="600"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EED22612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="666" mass="74543" checksum="FEA4B8C2541E96F1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2024-01-24" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>B8LV14</accession>
    <name>B8LV14_TALSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSTA_061260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)</name>
        <name type="synonym">Penicillium stipitatum</name>
        <dbReference type="NCBI Taxonomy" id="441959"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Trichocomaceae</taxon>
            <taxon>Talaromyces</taxon>
            <taxon>Talaromyces sect. Talaromyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="E0155914" last="E0155914">
            <title>Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).</title>
            <authorList>
                <person name="Nierman W.C."/>
                <person name="Fedorova-Abrams N.D."/>
                <person name="Andrianopoulos A."/>
            </authorList>
            <dbReference type="PubMed" id="25676766"/>
            <dbReference type="DOI" id="10.1128/genomea.01559-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EED22635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002339981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8LV14"/>
    <dbReference type="STRING" id="441959.B8LV14"/>
    <dbReference type="GeneID" id="8106175"/>
    <dbReference type="VEuPathDB" id="FungiDB:TSTA_061260"/>
    <dbReference type="HOGENOM" id="CLU_1125160_0_0_1"/>
    <dbReference type="InParanoid" id="B8LV14"/>
    <dbReference type="PhylomeDB" id="B8LV14"/>
    <dbReference type="Proteomes" id="UP000001745">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EED22635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001745"/>
        </source>
    </evidence>
    <sequence length="247" mass="28455" checksum="797005F156AC94B2" modified="2009-03-03" version="1">MHKERPLRYYFDNKDEWVRRGINPISAVKSYFETKEHLRFVQSQWDAMNLASTMNLSGAMKRRLLLFKACISNPSRPCVPRHNWKIFTKYLQPYTGSMINHVRHTEDIHHTDEATHKEGAIYAT